Дисертації з теми "Half-sandwich"
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McCamley, Andrew. "Photochemistry of half-sandwich complexes in matrices." Thesis, University of York, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238716.
Повний текст джерелаPuntambekar, Shakher Gajanan. "Half-sandwich arene iron complexes : synthesis and reactivity." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329900.
Повний текст джерелаColes, Stuart Raymond. "Half-sandwich group 4 complexes in alkene polymerisation." Thesis, University of Warwick, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439647.
Повний текст джерелаBillah, Syed Abul Muzaddad Mustafij. "Half-sandwich indenyl and related compounds of ruthenium(II)." Thesis, University of Salford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262619.
Повний текст джерелаHollandsworth, Carl B. "Full and half sandwich compounds of dimolybdenum and ditungsten." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1095455882.
Повний текст джерелаBătinaş, Aurora Alexandra. "The chemistry of half-sandwich vanadium imido-amido complexes." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2009. http://irs.ub/rug.nl/ppn/318.
Повний текст джерелаHollandsworth, Carl Burton. "Full and half sandwich compounds of dimolybdenum and ditungsten." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1095455882.
Повний текст джерелаTitle from first page of PDF file. Document formatted into pages; contains xxi, 215 p.; also includes graphics (some col.). Includes bibliographical references (p. 209-215).
Svačina, Zdeněk. "Příprava syndiotaktického polystyrenu pomocí monocyklopentadienylových komplexů titanu." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2008. http://www.nusl.cz/ntk/nusl-216371.
Повний текст джерелаMaddox, Tania Patricia. "Thermal and photochemical reactions of half sandwich transition metal complexes." Thesis, University of York, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284128.
Повний текст джерелаCapper, Glen. "Half-sandwich organoruthenium and organorhodium complexes of biologically relevant ligands." Thesis, University of Leicester, 1995. http://hdl.handle.net/2381/34044.
Повний текст джерелаJames, J. Thomas. "Half-sandwich hydrazido and alkoxylimido complexes of the early transition metals." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320162.
Повний текст джерелаMistry, Neetisha Shantilal. "Mechanistic studies into the catalytic activity of half-sandwich ruthenium complexes." Thesis, University of York, 2013. http://etheses.whiterose.ac.uk/5282/.
Повний текст джерелаDa, Lio Sebastiano <1988>. "HALF-SANDWICH COMPLESSI DI RUTENIO: PREPARAZIONE E REATTIVITÀ DI DERIVATI ORGANOSTANNILICI." Master's Degree Thesis, Università Ca' Foscari Venezia, 2012. http://hdl.handle.net/10579/1975.
Повний текст джерелаGasparato, Dario <1987>. "HALF-SANDWICH COMPLESSI DI OSMIO: PREPARAZIONE E REATTIVITÀ DI NUOVI DERIVATI." Master's Degree Thesis, Università Ca' Foscari Venezia, 2012. http://hdl.handle.net/10579/2027.
Повний текст джерелаCapponi, Marco <1979>. "Preparazione e reattività di "half-sandwich" complessi con azine come leganti." Master's Degree Thesis, Università Ca' Foscari Venezia, 2016. http://hdl.handle.net/10579/7562.
Повний текст джерелаJohnson, Tony Richard. "Vinylidene and cyclic carbene chemistry of iron and manganese half-sandwich complexes." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340247.
Повний текст джерелаScapinello, Maria Federica <1986>. "Preparazione e reattività di "half-sandwich" complessi di rutenio con legante indenilico." Master's Degree Thesis, Università Ca' Foscari Venezia, 2012. http://hdl.handle.net/10579/1749.
Повний текст джерелаTrevisan, Mauro <1989>. "Preparazione e reattività di "half-sandwich" carbeni complessi stabilizzati da leganti bipiridilici." Master's Degree Thesis, Università Ca' Foscari Venezia, 2016. http://hdl.handle.net/10579/9260.
Повний текст джерелаBrunker, Timothy J. "Studies of half-sandwich tris(pyrazolyl)borate complexes of first row transition metals." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393565.
Повний текст джерелаWalters, Stephen John. "Acyl(oxy) carbene and vinylidene chemistry of iron and ruthenium half-sandwich complexes." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245691.
Повний текст джерелаRovida, Giulio <1992>. "Preparazione e reattività di complessi half-sandwich di rutenio e un legante allilfosfinitico." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/14816.
Повний текст джерелаChan, Michael. "Stoichiometric and catalytic reactivity of half-sandwich imido complexes of the group 5 metals." Thesis, Durham University, 1995. http://etheses.dur.ac.uk/5209/.
Повний текст джерелаGeddes, Keira M. "The synthesis of novel planar chiral ansa-half-sandwich metallocenes containing a ferrocene linker." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415022.
Повний текст джерелаGasparetto, Giulia <1991>. "Preparazione e reattività di half-sandwich complessi di rutenio e iridio con leganti idrazinici." Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/9759.
Повний текст джерелаKarpin, George W. "Synthesis and Antimicrobial Activity of Half-Sandwich Ir(III), Rh(III), and Co(III) Complexes." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/79414.
Повний текст джерелаPh. D.
Assoua, Mebi Charles. "Half-sandwich ruthenium (II) complexes of 1,3,5-triaza-7-phosphaadamantane syntheses, reactivity, and catalytic application /." abstract and full text PDF (free order & download UNR users only), 2007. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3258845.
Повний текст джерелаPoole, Andrew D. "Half-sandwich imido and related complexes of niobium and tantalum : relatives of the Zirconocene family." Thesis, Durham University, 1992. http://etheses.dur.ac.uk/5809/.
Повний текст джерелаAlharis, Raed Awad Aubed. "Electronic effect on C-H activation at half sandwich complexes of Ir, Rh and Ru." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/41219.
Повний текст джерелаMelis, Diana. "Quinoline-triazole half-sandwich iridium(III) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies." Master's thesis, Faculty of Science, 2020. http://hdl.handle.net/11427/32414.
Повний текст джерелаLev, Daniel Abraham. "Group 8 and 9 half sandwich complexes of N-heterocyclic phosphines : synthesis, reactivity, and catalysis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3158465.
Повний текст джерелаČubrilo, Jadranka. "Contributions to the chemistry of arene ruthenium half sandwich complexes complexes bearing labile chalcogen ligands and alkynol coupling reactions /." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-33824.
Повний текст джерелаWang, Min [Verfasser], and Michael [Akademischer Betreuer] Buchmeiser. "Synthesis of half-sandwich group 4 transition metal catalysts for tandem ring-opening metathesis/vinyl insertion polymerization / Min Wang ; Betreuer: Michael Buchmeiser." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2016. http://d-nb.info/1118369459/34.
Повний текст джерелаRoberts, Hannah Nike. "The use of molecular design to fine-tune the redox properties and electronic structure of half-sandwich group 6 metal acetylide complexes." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/the-use-of-molecular-design-to-finetune-the-redox-properties-and-electronic-structure-of-halfsandwich-group-6-metal-acetylide-complexes(622ea5ae-2d9c-4523-ace3-165e51e93be5).html.
Повний текст джерелаHu, Wanning [Verfasser], and Ulrich [Akademischer Betreuer] Schatzschneider. "Organometal half-sandwich complexes and their bioconjugates: Biological activity on cancer cells and potential applications in biolabelling / Wanning Hu. Betreuer: Ulrich Schatzschneider." Würzburg : Universität Würzburg, 2013. http://d-nb.info/1109770944/34.
Повний текст джерелаMorris, David. "Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/71819.
Повний текст джерелаPh. D.
Yu, Yan [Verfasser], та Peter [Akademischer Betreuer] Burger. "Synthetic, Structural, Spectroscopic and Electrochemical Studies of Dinuclear bis μ-Oxo-Bridged Molybdenum(IV) and Tungsten(IV) Half-Sandwich Complexes / Yan Yu. Betreuer: Peter Burger". Hamburg : Staats- und Universitätsbibliothek Hamburg, 2014. http://d-nb.info/1052996701/34.
Повний текст джерелаHenrion, Mickaël. "Synthesis and homogeneous catalytic applications of nickel(II)-N-heterocyclic carbene complexes." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF057/document.
Повний текст джерелаA detailed study has been conducted on organometallic compounds of N-heterocyclic carbenes (NHC) of nickel(II), in particular on half-sandwich nickel(II)−NHC complexes. These complexes showed unprecedented catalytic activity in homogeneous catalysis, especially in the α-arylation of acyclic ketones, where catalyst loadings as low as 1 mol% could be used. Mechanistic experiments suggest that radicals are implied. Furthermore, these half-sandwich complexes proved to be efficient pre-catalysts in the hydrosilylation of carbonyl compounds and imines, allowing the reduction processes to proceed under mild reaction conditions. During the course of these studies, a half-sandwich nickel−hydride intermediate that probably acts as the true pre-catalyst was isolated. Remarkably, the synthesis of new Ni−NHC complexes led to a methodology for cyclopentadienyl ligand substitution in stable 18-electron alkyl,NHC−Ni derivatives. Finally, the use of less common NHC ligands, such as NHCs possessing a malonate backbone, or else, the use of cyclic (alkyl)(amino) carbenes, led to the isolation of new nickel−carbene complexes, which gave encouraging preliminary catalytic results
Assim, Khaybar. "Synthese und Charakterisierung von Übergangsmetallkomplexen zur Herstellung von nanostrukturierten Materialien." Doctoral thesis, Universitätsbibliothek Chemnitz, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-224679.
Повний текст джерелаAhmad, Shah Masood. "Filling the Structure-Reactivity Gap: in silico approaches to rationalize the design of molecular catalysts." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3422346.
Повний текст джерелаJing-Chang, Kuo, and 郭憬忠. "Preparation and Application of Half-Sandwich Metallocene." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/82917229361865706501.
Повний текст джерела國立中正大學
化學工程研究所
89
In this work, our research has been focused on the following two topics, which involve using the half-sandwich metallocene complexes as the polymerization catalysts. 1.To develop new catalyst composition for the syndiospecific polymerization of styrene. 2.To study the cyclo-copolymerization of 1,5-headiene with norbornene for the preparation of a novel cyclic polymer. In the first part of our studies, we have used the Group II and Group III cyclopentadienyl complexes as one of the catalyst component to combine titanium alkoxide and MAO for in situ generating the active catalyst for syndiospecific polymerization of styrene. Experimental results clearly indicate the reaction between Group II and Group III cyclopentadienyl complexes and titanium alkoxide lead to the formation of a cyclopentadienyl containing titanium complex (a half-sandwich metallocene catalyst), which is responsible for the high reactivity in the current catalyst system. In the second part of our work, the preparation of a new cyclopolymer is accomplished by using a half-sandwich metallocene catalyst to undergo the cyclo-copolymerization of 1,5-hexadiene and norbornene. Experimental results show that the new cyclic copolymer has a higher glass transition temperature comparing with the polymer prepared from the homo-cyclopolymerization of 1,5-hexadiene. Structural analyses by 1H 13C NMR clearly indicate the incorporation of norbornene as comonomer in the resulting copolymer.
"Synthesis and structural characterization of half- and full-sandwich group 4 metallacarboranes." 2002. http://library.cuhk.edu.hk/record=b5891274.
Повний текст джерелаThesis (M.Phil.)--Chinese University of Hong Kong, 2002.
Includes bibliographical references (leaves 98-102).
Abstracts in English and Chinese.
Acknowledgement --- p.I
Abstract (in English) --- p.II
Abstract (in Chinese) --- p.III
Abbreviation --- p.V
List of Compounds --- p.VI
Contents --- p.VII
Chapter Chapter 1. --- Introduction
Chapter 1.1 --- Metallacarboranes of the C2B4 Systems --- p.1
Chapter 1.1.1 --- Group 1 Metallacarboranes of the C2B4 Systems --- p.3
Chapter 1.1.2 --- Group 4 Metallacarboranes of the C2B4 Systems --- p.6
Chapter 1.2 --- Group 4 Metallacarboranes of the C2B9 Systems --- p.17
Chapter 1.3 --- Group 4 Metallacarboranes of the C2B10 Systems --- p.35
Chapter 1.4 --- Applications of Group 4 Metallacarboranes --- p.44
Chapter 1.5 --- Research Objectives --- p.47
Chapter Chapter 2. --- Synthesis and Structural Characterization of Group4 Metallacarboranes of the C2B9 Systems
Chapter 2.1 --- Synthesis and Structural Characterization of {{466}4:η2-[(C6H5CH2)2C2B9H9]2ZrCl(THF)} {Na(THF)3} --- p.48
Chapter 2.2 --- Synthesis and Structural Characterization of [η4:η2- {(C6H5CH2)2C2B9H9} 2ZrCl(THF)] [Li(THF)4] --- p.54
Chapter 2.3 --- Synthesis and Structural Characterization of ZrCl[N(SiMe3)2]3 --- p.57
Chapter 2.4 --- "Synthesis and Structural Characterization of η2-(C6H5CH2)2C2B9H9]M(NEt2)2(NHEt2HCH2Cl2) (M = Ti, Zr)" --- p.62
Chapter 2.5 --- "Synthesis and Structural Characterization of [μ-{ o-C6H4(CH2)2 }C2B9H9]2M(THF)2 (M = Zr, Hf)" --- p.68
Chapter 2.6 --- Conclusion --- p.71
Chapter Chapter 3. --- Synthesis and Structural Characterization of Group4 Metallacarboranes of the C2B10 Systems
Chapter 3.1 --- "Synthesis and Structural Characterization of {{471}-l,,2-(o-C6H4(CH2)2)- 1,2-C2B 10H10]2Zr} {Na(THF)3}2 and {[μ-l,2-(o-C6H4(CH2)2)-l,2- C2B10H10]2ZrCl2} {Na(THF)3}2(THF)" --- p.72
Chapter 3.2 --- Conclusion --- p.78
Chapter Chapter4. --- Summary --- p.79
Chapter Chapter5. --- Experimental Section --- p.81
References --- p.98
Appendix
Chapter I. --- Crystal Data and Summary of Data Collection and Refinement --- p.103
Chapter II. --- Atomic Coordinates and Thermal Parameters --- p.109
Chapter III. --- Bond Distances and Angles --- p.117
Paciello, Rocco Angelo. "Synthesis and Reactivity of Electron-Rich Ruthenium and Iron Half-Sandwich Complexes." Thesis, 1987. https://thesis.library.caltech.edu/11846/2/Paciello_RA_1987.pdf.
Повний текст джерелаLate transition metal organometallic complexes, Cp*(PR3)2MX (Cp* = η5-C5Me5), with highly electron donating ligand sets have been synthesized and their reactivity studied. Synthetic routes which allow systematic variation of metal (Ru, Fe), phosphines (PMe3, PEt3, PnBu3, PMe2Ph, DMPE), and sigma-bonded ligands (halide, hydride, alkyl, heteroatom) have been developed.
Thermally and photochemically induced ligand loss from these complexes has been studied. Trapping and C-H bond activation chemistry have been observed for the transient [Cp*(PR3)MX] complexes produced upon ligand loss. The reactivity of analogous ruthenium and iron complexes is compared and discussed.
The Ru(IV) complex, Cp*(PMe3)RuH3, has been prepared and isolated. This complex is found to catalyze H-D exchange, and hydrogenations of unsaturated organic species. The analogous Fe(IV) complex, Cp*(PMe3)FeH3, has been prepared and observed spectroscopically. Hydrogen bonding modes in these polyhydrides are discussed. Highly fluxional Cp*(PMe3)FeH3 is proposed to be in equilibrium with Cp*(PMe3)Fe(η2-H2)H.
An equilibrium method for the determination of relative Ru-X and Ru-Y bond strengths in Cp*(PMe3)2RuX has been developed. A linear correlation of Ru-X to H-X bond strengths has been found over a wide range of ligands, X. The relationship is found to be general for a number of metal centers.
A study of the kinetics of phosphine exchange for Cp*(PMe3)2RuX has been undertaken. The rate of phosphine loss can be abstracted from a treatment of the kinetics of approach to equilibrium. Lone pairs on X are found to promote ligand dissociation. Dative bond dissociation enthalpies are obtained if small, and constant, barriers for ligand recombination are assumed. The functional group approximation used in solution thermochemical studies is found to break down when large changes are made in the steric constraint at the metal center.
Pitto-Barry, Anaïs, A. South, A. Rodger, and Nicolas P. E. Barry. "The synthesis and unexpected solution chemistry of thermochromic carborane-containing osmium half-sandwich complexes." 2015. http://hdl.handle.net/10454/11260.
Повний текст джерелаThe functionalisation of the 16-electron complex [Os(η6-p-cymene)(1,2-dicarba-closo-dodecarborane- 1,2-dithiolato)] (1) with a series of Lewis bases to give the 18-electron complexes of general formula [Os(η6-p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolato)(L)] (L = pyridine (2), 4-dimethylaminopyridine (3), 4-cyanopyridine (4), 4-methoxypyridine (5), pyrazine (6), pyridazine (7), 4,4’-bipyridine (8) and triphenylphosphine (9)) is reported. All 18-electron complexes are in equilibrium in solution with the 16-electron precursor, and thermochromic properties are observed in some cases (2, 3, 5, 8, and 9). The binding constants and Gibbs free energies of the equilibria are determined using UV-visible titrations and their stabilities investigated. Synthetic routes for forcing the formation of the 18-electron species are proposed, and analytical methods to characterise the equilibria are described.
We thank the Leverhulme Trust (Early Career Fellowship No. ECF-2013-414 to NPEB), and the University of Warwick (Grant No. RD14102 to NPEB).
Yang, Jin. "The study of ruthenium(II) half-sandwich phosphido complexes containing pentamethylcyclopentadienyl (Cp*) ligand." Thesis, 2016. http://hdl.handle.net/1828/7678.
Повний текст джерелаGraduate
2017-12-11
0488
yangjin@uvic.ca
"Half-sandwich group 4 metallacarborane monoamides and their application in synthesis of 2-aminoimidazoles." 2012. http://library.cuhk.edu.hk/record=b5894909.
Повний текст джерела"October 2011."
Thesis (M.Phil.)--Chinese University of Hong Kong, 2012.
Includes bibliographical references (leaves 87-92).
Abstracts in English and Chinese.
Acknowledgement --- p.I
Abstract (in English) --- p.III
Abstract (in Chinese) --- p.IV
Abbreviation --- p.V
List of Compounds --- p.VI
List of Figures --- p.IX
Contents --- p.X
Chapter Chapter 1 --- Introduction --- p.1
Chapter 1.1 --- Synthesis and Structure of Half-Sandwich Group 4 Metallocarboranes Containing the Dicarbollyl Ligand --- p.2
Chapter 1.2 --- Half-Sandwich Group 4 Metallacarboranes Catalyzed Reactions --- p.20
Chapter 1.2.1 --- Polymerization of Olefins --- p.20
Chapter 1.2.2 --- Catalytic Dimerization and Hydrogenation of Alkynes --- p.22
Chapter 1.2.3 --- Catalytic Addition of Amines to Carbodiimides --- p.23
Chapter 1.2.4 --- Catalytic Transamination of Guanidines --- p.24
Chapter 1.2.5 --- Catalytic Synthesis of A^-Heterocycles --- p.25
Chapter 1.3 --- Research Objectives of This Thesis --- p.26
Chapter Chapter 2 --- Half-Sandwich Group 4 Metallacarborane Monoamindes --- p.27
Chapter 2.1 --- Introduction --- p.27
Chapter 2.2 --- Synthesis of Dicarbollyl Ligands Bearing Functional Side Arms --- p.27
Chapter 2.3 --- Synthesis and Characterization of Half-Sandwich Group 4 Metallacarborane Monoamindes --- p.33
Chapter 2.4 --- Summary --- p.43
Chapter Chapter 3 --- Synthesis of 2-Aminoimidazoles Catalyzed by Half-Sandwich Titanacarborane Monoamide --- p.44
Chapter 3.1 --- Introduction --- p.45
Chapter 3.2 --- Known Methods for the Synthesis of 2-Aminoimidazole --- p.44
Chapter 3.2.1 --- Condensations Methods --- p.44
Chapter 3.2.2 --- Direct Introduction of N at C2 Position --- p.46
Chapter 3.2.3 --- Heterocyclic Exchange Reactions --- p.47
Chapter 3.2.4 --- Transition Metal Catalyzed Reactions --- p.48
Chapter 3.3 --- Results and Discussion --- p.49
Chapter 3.3.1 --- Synthesis of Propargy 1 Amines --- p.49
Chapter 3.3.2 --- Synthesis and Characterization of 2-Aminoimidazoles --- p.50
Chapter 3.3.3 --- Proposed Reaction Mechanism --- p.55
Chapter 3.4 --- Summary --- p.57
Chapter Chapter 4 --- Conclusion --- p.59
Chapter Chapter 5 --- Experimental Section --- p.61
References --- p.87
Appendix
Chapter I. --- Publication Based on the Research Findings --- p.93
Chapter II. --- Crystal Data and Summary of Data Collection and Refinement --- p.94
Chapter III. --- X-ray crystallographic data in CIF (electronic form)
Soldevila-Barreda, Joan J., K. B. Fawibe, Maria Azmanova, Laia Rafols, Anaïs Pitto-Barry, U. B. Eke, and Nicolas P. E. Barry. "Synthesis, characterisation, and in vitro anticancer activity of catalytically active indole-based half-sandwich complexes." 2020. http://hdl.handle.net/10454/18070.
Повний текст джерелаThe synthesis, characterisation and evaluation of the in vitro cytotoxicity of four indole-based half-sandwich metal complexes towards two ovarian cancer cell lines (A2780 and A2780cisR) and one normal prostate cell line (PNT2) are presented herein. Although capable of inducing catalytic oxidation of NADH and able to reduce NAD+ with high turnover frequencies, in cells and in the presence of sodium formate, these complexes also strongly interact with biomolecules such as glutathione. This work highlights that efficient out-of-cells catalytic activity might lead to higher reactivity towards biomolecules, thus inhibiting the in-cells catalytic processes.
Pitto-Barry, Anaïs, A. Lupan, Markus Zegke, Thomas Swift, A. A. A. Attia, Rianne M. Lord, and Nicolas P. E. Barry. "Pseudo electron-deficient organometallics: limited reactivity towards electron-donating ligands." 2017. http://hdl.handle.net/10454/13140.
Повний текст джерелаHalf-sandwich metal complexes are of considerable interest in medicine, material, and nanomaterial chemistry. The design of libraries of such complexes with particular reactivity and properties is therefore a major quest. Here, we report the unique and peculiar reactivity of eight apparently 16-electron half-sandwich metal (ruthenium, osmium, rhodium, and iridium) complexes based on benzene-1,2-dithiolato and 3,6-dichlorobenzene-1,2-dithiolato chelating ligands. These electron-deficient complexes do not react with electron-donor pyridine derivatives, even with the strong σ-donor 4-dimethylaminopyridine (DMAP) ligand. The Ru, Rh, and Ir complexes accept electrons from the triphenylphosphine ligand (σ-donor, π-acceptor), whilst the Os complexes were found to be the first examples of non-electron-acceptor electron-deficient metal complexes. We rationalized these unique properties by a combination of experimental techniques and DFT/TDFT calculations. The synthetic versatility offered by this family of complexes, the low reactivity at the metal center, and the facile functionalization of the non-innocent benzene ligands is expected to allow the synthesis of libraries of pseudo electron-deficient half-sandwich complexes with unusual properties for a large range of applications.
Hu, Wanning. "Organometal half-sandwich complexes and their bioconjugates: Biological activity on cancer cells and potential applications in biolabelling." Doctoral thesis, 2012. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-87899.
Повний текст джерелаIn der vorliegenden Arbeit konnten also Struktur-Wirkungs-Beziehungen für Organometall-Peptid- und Dendrimer-Konjugate mit unterschiedlichen funktionellen Gruppen an einer humanen Brustkrebs-Zelllinie untersucht werden. Die Variation der Organometall-Gruppen und des Trägermoleküls führen zu signifikanten Unterschieden in ihrer biologischen Aktivität. Zusätzlich wurden Modell-Peptide mit verschiedenen Metallcarbonyl-basierten IR-Markern versehen um diese in einer Barcoding-Strategie zu labeln. In Zukunft soll das Spektrum der verfügbaren, nicht-überlappenden Schwingungsmarker noch deutlich erweitert werden
Habas, Khaled S. A., Barreda Joan J. Soldevila, Maria Azmanova, Laia Rafols, Anaïs Pitto-Barry, Diana Anderson, and Nicolas P. E. Barry. "Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals." 2020. http://hdl.handle.net/10454/18162.
Повний текст джерелаElectron‐deficient half‐sandwich complexes are a class of under‐studied organometallics with demonstrated potential as metallodrug candidates. The present study investigates the effect of two 16‐electron organoruthenium complexes ([( p‐ cym)Ru(benzene‐1,2‐dithiolato)] ( 1 ) and [( p ‐cym)Ru(maleonitriledithiolate)] ( 2 )) on the cell viability of non‐immortalised human lymphocytes from healthy individuals. The genotoxic effects of 1 and 2 in lymphocytes using the Comet and cytokinesis‐block micronucleus assays is also investigated. Gene expression studies were carried out on a panel of genes involved in apoptosis and DNA damage repair response. Results show that the two 16‐electron complexes do not have significant effect on the cell viability of human lymphocytes from healthy individuals. However, an increase in DNA damage is induced by both compounds, presumably through oxidative stress production.
This project was supported by the Royal Society (University Research Fellowship No. UF150295 to NPEB), the University of Bradford (RDF Award), and by the Academy of Medical Sciences/the Wellcome Trust/ the Government Department of Business, Energy and Industrial Strategy/ the British Heart Foundation Springboard Award [SBF003\1170 to NPEB].
The full-text of this article will be released for public view at the end of the publisher embargo on 30 Oct 2021.
Lee, Bo-ting, and 李柏庭. "Syntheses and Polymerization Studies of Half-Sandwich Metallocene Complexes Prepared by The Selective Cyclopentadienyl Ligand Transfer Reactions." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/47131877068965914066.
Повний текст джерела國立中正大學
化學工程所
95
A novel synthetic route for the preparation of monocyclopentadienyl group(ⅣB) metal complexs via cyclopentadienyl ligand transfer reaction was disclosed in this study.The cyclopentadienyl ligand transfer reactions are conducted by using transition metal alkoxides (titanium, zirconium, hafnium,alkoxides) as the Cp-ligand acceptors to react with group (II) Cp-containing complexes (Cp2Mg、Cp*2Mg and nPrCp2Mg), which act as the Cp-ligand donors.The new synthetic methods lead to the successful generation of monocyclopentadienyl complexs of Titanium、Zirconium and Hafnium.The polymerizations of vinyl monomers using these catalysts have been investigated. This new synthetic route offers the preparation of novel mono-cyclopentadienyl complexs of Zirconium and Hafnium,which are difficult to preparated by other methods.