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1
Griffiths, Leigh. "Angiogenic growth factors in tumour growth." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312384.
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Fitzgerald, Peter. "Growth." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1789.
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3
Ross, Erin Sundseth. "Early growth faltering predicts longitudinal growth failure /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.
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Thesis (Ph.D. in Clinical Science) -- University of Colorado Denver, 2007.Typescript. Includes bibliographical references (leaves 130-146). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
4
陳蒓 and Tzun Rachel Chan. "Growth hormone therapy for growth hormone deficiency." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31970308.
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5
Dinis, Ariane Vaz. "Growth accounting: how institutions affect Portugal's growth." Master's thesis, NSBE - UNL, 2013. http://hdl.handle.net/10362/11596.
Повний текст джерелаАнотація:
A Work Project, presented as part of the requirements for the Award of a Masters Degree in Economics from the NOVA – School of Business and EconomicsThe main objective of this Work Project (WP) is to understand whether institutional quality has been determinant to the increase of Portugal's productivity. This WP provides a sector-wise Growth Accounting exercise and analyzes the Total Factor Productivity (TFP) growth. Secondly, it uses a cross-country approach to understand which institutional indicators influence TFP growth. This WP considers, based on GMM estimation, different models to capture the causality between productivity growth and Institutional Quality. The results obtained reveal a positive relation between TFP growth and Institutional Quality.
6
Chan, Tzun Rachel. "Growth hormone therapy for growth hormone deficiency." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22926288.
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7
Ochoa, Banafsheh K. "Maxillary growth in comparison to mandibular growth." Oklahoma City : [s.n.], 2002. http://library.ouhsc.edu/epub/theses/Ochoa-Banafsheh-K.pdf.
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8
Mogos, Serban Ioan. "High Growth Entrepreneurship: A Multi-Level Perspective on Firm Growth and Growth Policy." Research Showcase @ CMU, 2017. http://repository.cmu.edu/dissertations/1106.
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Entrepreneurship is the force that drives economic, social and technical progress. A small percentage of firms (5%) is responsible for a disproportionately large amount of net job creation (>50%). Named high growth firms, these successful enterprises have been in the spotlight of research looking into the key drivers of firm growth and growth policy. This dissertation explores high growth from multiple perspectives: at the level of the firm, by understanding how the definition of a high growth firm impacts its characteristics and expected performance over time; at the local level, by isolating the effect of political connections of firm performance and firm entry; and at the macro level, by observing the evolution of entrepreneurship during transition. The first study finds that most HGFs are unable to maintain high growth rates for long, but do register lower volatility in growth rates and a higher chance of survival. Results on growth volatility and persistence vary significantly with the specific definition of “high growth” used as well as with the specific variable used to measure growth (e.g., revenue, employees, profit, productivity). These findings have direct implications for growth policies and programs that depend on identifying HGFs. The second study indicates a strong significant effect of political alignment on revenue growth and firm entry. Larger firms take advantage of political connections for performance gains, while small firms are negatively impacted. Furthermore, alignment reduces entry into entrepreneurship by 8-11%. These findings establish political alignment and local-level business-politics collusion as important dynamics to consider when evaluating entrepreneurship policy in developing countries. The third study describes the interdependence between entrepreneurship, institutions, and transitions. The case of Romania shows that the beginning of transition was characterized by an initial explosion of newly created private enterprises, followed by a declining trend in enterprise creation and, recently, by a new increase in entrepreneurship activity. To conclude, this work contributes new perspectives towards a better understanding of high growth firms and growth policy. Policy implications are targeted towards transition and developing economies that have seen little representation in literature. The goal is to enable successful high growth policies across multiple levels.
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Ruddiman, Elizabeth P. "Is Smart Growth Fair Growth: Do Urban Growth Boundaries Keep out Racial Minorities?" unrestricted, 2007. http://etd.gsu.edu/theses/available/etd-08062007-090141/.
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Thesis (Ph. D.)--Georgia State University, 2007.Title from file title page. Charles Jaret , committee chair; Robert Adelman, Donald Reitzes, committee members. Electronic text (96 p. : ill.) : digital, PDF file. Description based on contents viewed Nov. 1, 2007. Includes bibliographical references (p. 88-94).
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ABUDULIMU, ABASI. "Effectof Growth Time, Growth Temperature and Light on Growth Mechanism of C60 nanorods." Thesis, Umeå universitet, Institutionen för fysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79368.
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In this thesis work C60 nanorods were produced by Liquid-Liquid Interfacial Precipitation method (LLIP) assisted with 10 s of weak sonication. Ethanol and m-dichlorobenzene were used as poor and good solvents of C60, respectively. Five different temperatures, 4, 10, 20, 30, 40 and 50 , were chosen as growth temperatures of different samples to investigate the effect of temperature on the grown structures. Different samples were prepared in the dark and under the light with various growth time to determine the effect of light and growth time on growth of C60 nanorods. The characterization of the grown C60 nanorods were conducted by transmission electron microscopy (TEM) and x-ray diffraction (XRD). The result of characterization indicated that the sonication introduced smaller C60 nanostructures; light irradiation and temperature increase (till 40 C0) during the growth time resulted in nanorods with smaller diameter, whereas the long growth time lead to the increase of the diameter of C60 nanorods. The as-grown C60 nanorods synthesized at different conditions possess an hcp crystal structure.
11
Burns, Jason Lee. "Growth control by insulin-like growth factor II." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270285.
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12
Magrini, Samantha H. "Bone Growth: The Wake of the Growth Plate." Kent State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=kent162669258742215.
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13
Bayley, Christopher. "Growth factor interactions with platelet-derived growth factor receptor alpha." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/growth-factor-interactions-with-plateletderived-growth-factor-receptor-alpha(a263bc70-8de0-4168-bda4-a3b1b05a2c0f).html.
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The interaction between a growth factor and the extracellular region of its receptor is the first step in triggering the intracellular signalling pathways that induce a change in cell phenotype. Several platelet-derived growth factors (PDGFs) each bind to and activate PDGF receptor (PDGFR) alpha, a transmembrane receptor tyrosine kinase that simulates proliferation and migration in cells of mesenchymal origin. PDGFR alpha itself activates several intracellular signalling pathways. Thus, the possibility exists that different growth factors interact with PDGFR alpha in distinct ways to elicit divergent cellular effects. This possibility was investigated by examining the interactions that occur between the extracellular region of PDGFR alpha and three growth factors: PDGF-AA, PDGF-BB and vascular endothelial growth factor-A165 (VEGF-A165). The extracellular region of PDGFR alpha, and fragments thereof, were recombinantly expressed by mammalian 293-EBNA cells. The affinities of the protein fragments for each of the three growth factors were assayed by solid phase binding analysis. Each growth factor had a different affinity both for the extracellular region of PDGFR alpha and the fragments of that region, indicating that they differentially interact with the receptor. These different growth factor/receptor interactions were further investigated by substituting charged amino acids for uncharged residues in the putative ligand binding domain of PDGFR alpha. The amino acids selected for substitution were analogous to residues that had been shown to form direct contacts with growth factors in growth factor/receptor systems that are evolutionarily related to PDGFR alpha. Mutants of the PDGFR alpha ectodomain were generated by site-directed mutagenesis, and their growth factor binding properties were subsequently assayed. Particular mutants had differential effects on growth factor binding to PDGFR alpha. For example, the K209A mutant had no effect on PDGF-AA binding to the receptor, compared to wild-type, but it had a lower affinity for PDGF-BB and a greater affinity for VEGF-A165, compared to wild-type. These data demonstrated that the examined growth factors form subtly different interactions with PDGFR alpha. Thus, it is likely that each growth factor induces a distinct conformational change in the receptor upon binding. In this way, different growth factors may elicit divergent cellular effects through the same receptor.
14
Shangguan, D. K. "Cellular growth." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330294.
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15
Wan, Xianhua. "Dendritic growth." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242042.
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16
Holmes, Sarah Jane. "Growth hormone replacement in adults with growth hormone deficiency." Thesis, Imperial College London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297239.
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17
Chaffey, C. M. "The effects of epidermal growth factor on muscle growth." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306697.
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18
Al-Doski, Shaker. "Effects of growth promoters on sheep metabolism and growth." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/30739/.
Повний текст джерелаАнотація:
The aim of this thesis was to investigate the mechanisms that mediate the effects of beta-adrenergic agonists (BA) and Growth Hormone (GH) in sheep, by examining the changes in skeletal muscle transcriptome and blood metabolome in order to identify the predominant metabolic mechanisms by which muscle hypertrophy was mediated. Male lambs (120 days old) were all fed a high protein/energy feed ad-libitum, with the GH group (n=10) receiving a single subcutaneous injection of bovine GH (3.75mg/kg body weight, POSILAC, Monsanto) on day 1; the BA group (n=10) receiving BA (cimaterol) at 10mg/kg feed, whereas the control group (CO, n=11) only had the ad-libitum feed. After 6 days sheep were slaughtered, plasma and samples of the Longissimus dorsi (LD), Supraspinatus (SS) muscles and liver were collected. The effect of treatments on the LD transcriptome was assessed on a subset of samples (n=3 from each treatment) via a cross-species approach using the Affymetrix Human U133+2 GeneChip array (47K human microarray). Verification of identified differentially expressed genes and proteins was by quantitative RT-PCR or western blotting, respectively, on all animals. Metabolomics analysis of plasma samples was carried out by Metabolon Inc. (USA) using GC/MS and LC/MS/MS platforms. BA, but not GH, significantly (P<0.05) increased muscle weights and this was associated transition to large fast-glycolytic muscle fibre types. In GH, but not BA treated animals, there was an increase in liver weights (P<0.001). This was associated with an increase in the whole liver content of glycogen (P<0.001), protein (P<0.01), and lipid (P<0.05) content. Analysis of the LD transcriptome of the treated sheep identified 477 and 316 transcripts were significantly altered (P<0.05 and 1.5 fold change) by BA and GH respectively, relative to controls. This muscle was selected as it is a commercial valuable muscle and is commonly used for muscle biochemical studies therefore this would allow us to make comparisons to other studies, including our own. In addition it is a fast glycolytic muscle fibre type there could be compared against SS muscle (oxidative muscle fibre type). BA decreased the expression of genes involved with oxidative phosphorylation and upregulated those serine biosynthetic pathways. Subsequent qRT-PCR analysis showed a BA induced increase in expression of phosphoglycerate dehydrogenase (PHGDH) (P<0.05) and phosphoserine-aminotransferase (PSAT) (P<0.05) mRNA in both LD and SS but not liver. In LD there was also an increase (P<0.001) in PHGDH protein in muscle from BA treated sheep relative to GH treated sheep. Up-regulation of this pathway has been previously reported in cancer cells which has a tendency to be associated with an increase in gene expression of a specific isoform of the glycolysis enzyme pyruvate kinase (PKM2) which has reduced activity. Total PKM and PKM1 and PKM2 isoforms were increased in the SS and LD of BA treated sheep (P<0.05). Previous studies in cancer cells have suggested that increases in serine synthesis are mediated by changes in PKM2 expression and associated enzyme activity. The lack of a differential increase in PKM2 suggested that the regulation of muscle PK in BA treated animals was not critical to the potential increase in serine synthesis capacity. No clear change in PKM gene expression suggested this was not the mechanism by which the serine synthesis pathway was stimulated. There was an increase (P<0.05) in the expression the mitochondrial form of phosphoenolpyruvate carboxykinase (PCK2) in the LD of BA treated sheep, which might be expected to increase gluconeogenic potential thereby increasing intermediates that could be used for serine synthesis. There was no effect of this gene on sheep treated with GH. An increase in the gene expression of asparagine synthetase (ASNS) was also seen in the muscles of BA but not GH treated sheep (P<0.001) and there was no effect on their livers, which further suggested that BA was influencing the production of nonessential amino acids. Metabolomics analysis showed that products of triacylglycerol breakdown, glycerol and free fatty acids, were all elevated in the plasma of both BA and GH treatments, indicating lipolytic effects but the increase in the free fatty acid profile were more pronounced with GH treatment (P<0.05). Likewise GH rather than BA had a greater impact on elevating plasma glucose and associated metabolites such as pyruvate (P<0.05). There was no effect of either treatment on plasma serine or asparagine concentrations. However there was a decrease in glycine (P<0.05) and glutamine (P<0.05) in GH relative to control, with BA decreasing histidine (P<0.05) and methionine (P<0.01) relative to control. Cell culture experiments were carried out in the myogenic C2C12 cell line to determine if the genes associated with the GH and BA response in sheep were affected during myogenesis and whether there was an effect of des (1-3) IGF-I and dibutyryl cyclic adenosine monophosphate (dbcAMP) that stimulates GH and BA signalling pathways respectively. During differentiation, without treatment, gene expression of PHGDH and PSAT enzymes declined (P<0.05), which might be expected as cells move from a proliferative to a terminally differentiate state. There was no clear effect of treatment on genes associated with the serine synthesis pathway suggesting that the effects of BA, in particular, are on muscle fibres rather than differentiating cells. Of the two growth promoters examined in this thesis BA appears to be the most potent in skeletal muscle. A clear effect of this agent was an increase in the gene expression of the serine biosynthetic pathway, which has been shown to be upregulated in various cancers and, in this pathology, is thought to be a novel mechanism for hyperplastic growth. The associated changes in the expression of genes such as ASNS and PCK2 indicate that their co-ordinated upregulation could be mediated via endoplasmic reticulum stress response mechanisms. Unlike GH, BA does not appear to have a major effect upon the systemic mobilisation of nutrients, but instead seems to targets muscle fibres, activating muscle biosynthetic pathways that potentially provide the substrates required for growth.
19
Shang, Yi. "Measuring Student Growth with the Conditional Growth Chart Method." Thesis, Boston College, 2009. http://hdl.handle.net/2345/1818.
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Thesis advisor: Henry BraunThe measurement of student academic growth is one of the most important statistical tasks in an educational accountability system. The current methods of measuring student growth adopted in most states have various drawbacks in terms of sensitivity, accuracy, and interpretability. In this thesis, we apply the conditional growth chart method, a well-developed diagnostic tool in pediatrics, to student longitudinal test data to produce descriptive and diagnostic statistics about students' academic growth trajectory. We also introduce an innovative simulation-extrapolation (SIMEX) method which corrects for measurement error-induced bias in the estimation of the conditional growth model. Our simulation study shows that the proposed method has an advantage in terms of mean squared error of the estimators, when compared with the growth model that ignores measurement error. Our data analysis demonstrates that the conditional growth chart method, when combined with the SIMEX method, can be a powerful tool in the educational accountability system. It produces more sensitive and accurate measures of student growth than the other currently available methods; it provides diagnostic information that is easily understandable to teachers, parents and students themselves; the individual level growth measures can also be aggregated to school level as an indicator of school growth
Thesis (PhD) — Boston College, 2009
Submitted to: Boston College. Lynch School of Education
Discipline: Educational Research, Measurement, and Evaluation
20
Vekkateswarlu, P. "A study of statistical growth models and growth database." Thesis, Sheffield Hallam University, 1993. http://shura.shu.ac.uk/20476/.
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Plant Physiologists and crop modelers in general are keen to use non-linear models for their work. However, usual practice remains restricted to the use of linear form of growth curves due to lack of proper methodology for the application of non-linear models. This study is undertaken to review the statistical literature available on non-linear models, comparison of these models with data sets available. A database management system known as GROWDAT for growth data has been developed for a systematic storage and retrieval of growth data collected from several experiments. A copy of the software will be given on request.
21
Zhao, Lidan. "Mechanisms of growth hormone inhibition of adipose tissue growth." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/49588.
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Growth hormone (GH) is a poly-peptide hormone produced by the anterior pituitary. Growth hormone not only stimulates body and muscle growth but also inhibits adipose tissue growth. The overall objective of this study was to determine the mechanisms by which GH inhibits adipose tissue growth. Three studies were conducted to achieve this objective. The first study was conducted to determine if GH inhibits fat tissue growth by stimulating lipolysis. In this study, adipose tissue weight and adipocyte size were compared between GH-deficient growth hormone releasing hormone receptor (Ghrhr) homozygous mutant mice (i.e., lit/lit mice), lit/+ mice, and lit/lit mice injected with GH. lit/lit mice had less body weight but more subcutaneous fat and larger adipocytes compared to lit/+ mice at the same ages. GH treatment to lit/lit mice for four weeks partially reversed these differences. These data suggest that GH inhibits adipose tissue growth in mice at least in part by stimulating lipolysis. Additional data from this study suggest that GH indirectly stimulates lipolysis in vivo and this indirect mechanism is independent of " adrenergic receptors in the adipose tissue. The second study was conducted to investigate if GH inhibits fat tissue growth also by inhibiting adipogenesis. In this study, stromal vascular fraction (SVF) cells were isolated from subcutaneous fat of lit/+ and lit/lit mice and were induced to differentiate into adipocytes in vitro. Oil Red O staining and gene expression analysis revealed that the SVF cells from lit/lit mice had greater adipogenic potential than from lit/+ mice. This suggests that GH inhibits adipose tissue growth also through inhibition of adipogenesis. Additional data from this study suggest that GH may inhibit adipogenesis by inhibiting the formation of adipogenic precursor cells in adipose tissue in mice. The third study was conducted to determine the role of the central component of GH receptor signaling, STAT5, in GH inhibition of differentiation of bovine preadipocytes. In this study, preadipocytes were isolated from subcutaneous fat of adult cattle and were induced to differentiate with or without GH. Based on Oil Red O staining, gene expression, glycerol-3-phosphate dehydrogenase (G3PDH) activity and acetate incorporation assays, GH inhibited differentiation of bovine preadipocytes into adipocytes. GH induced phosphorylation of STAT5 in differentiating bovine preadipocytes. Overexpression of constitutively active STAT5 through adenovirus mimicked the effect of GH on differentiation of bovine preadipocytes. These data support a role of STAT5 in mediating the inhibitory effect of GH on differentiation of bovine preadipocytes into adipocytes. Overall, GH inhibits adipose tissue by both stimulating lipolysis and inhibiting adipogenesis; GH stimulates lipolysis through an indirect mechanism that is independent of the " adrenergic receptors; GH inhibits adipogenesis through a direct mechanism that may involve the transcription factor STAT5.Ph. D.
22
Zhu, Haibo. "Muscle Growth and Development in Intrauterine Growth Restricted Pigs." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/72883.
Повний текст джерелаАнотація:
Intrauterine growth restriction causes impaired growth and development of mammalian fetus, and leads to long-term negative effect on postnatal growth. Among domestic animals, pigs exhibit the most severe naturally occurring IUGR and reduced postnatal muscle growth. The objectives of this research project were to: 1) determine muscle stem cell characteristics in IUGR pigs; 2) determine how intrauterine growth restriction alters protein deposition in skeletal muscle; 3) investigate whether branched-chain amino acids (BCAA) are able to enhance protein synthesis in intrauterine growth restricted (IUGR) pig muscle. Newborn piglets were considered normal body weight (NBWT) or IUGR when birth weight was within ± 0.5 SD and -2 SD of litter average respectively. Muscle satellite cell numbers, believed to be the major nuclei source for postnatal muscle growth, were lower in newborn IUGR pigs which could result in reduced muscle hypertrophy potential. In addition, cultures derived from IUGR muscle satellite cells had a lower fusion percentage. Fewer satellite cells and impaired differentiation ability may contributor to impaired muscle growth in these pigs. Protein synthesis rate was significantly lower in IUGR pig hindquarter in the first hour after feeding, but BCAA supplementation had no effect on protein synthesis in IUGR pigs. Further, eukaryotic translation initiation factor 4E (eIF4E) expression is down regulated in IUGR pig muscle. These results suggest that impaired translation initiation may provide a plausible explanation for the lower protein synthesis rates observed in IUGR pigs. Overall, reduced muscle stem cell number and changes in their activity, as well as impaired translation initiation may be important explanations for compromised postnatal muscle growth in intrauterine growth restricted pigs.Ph. D.
23
Mushtaq, Talat. "Translational studies in growth plate research : the effect of glucocorticoids and growth factors on the growth plate." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/29290.
Повний текст джерелаАнотація:
This thesis consists of four major types of studies each utilising different models of growth and chondrocyte biology, which in combination strengthens the understandings of the effects of GC and growth factors on the growing skeleton. The initial in vivo study showed that in children treated with Dexamethasone (Dex) or Prednisolone (Pred) for Acute Lymphoblastic Leukaemia, the effects of Dex on body composition were more apparent in that it was up to 18 times more potent at reducing short term linear growth than Pred. The ATDC5 chondrocyte cell line was fully characterised, which allowed a unique opportunity to study GC effects on a homogeneous population of chondrocytes at the chondrogenesis and terminal differentiation phases. The GCs caused a reduction in cell number, cell proliferation and proteoglycan content whilst stimulating chondrocyte differentiation. These effects were dose dependent and only observed during the chondrogenesis phase when the cells are rapidly dividing. Furthermore these negative effects could be partially reversed with the use of a GC receptor antagonist and completely reversed with IGF-I. These observations were further translated into increasingly physiological models of bone growth. Foetal metatarsal organ explants, where the three dimensional structure and cell connections of the growing bone remain intact, again demonstrated that Dex and IGF-I had opposite effects on bone growth. In contrast to Dex the effects of IGF-I were immediate. IGF-I increased the size of the hypertrophic zone, and this accounted for most of the increase in metatarsal length. Prenatal administration of Dex caused a reduction in birth weight and length and this difference was greater in the female mice. The growth restriction was associated with an elevated IGF-I and IGFBP-2 levels raising the possibility of a state of IGF-I insensitivity, which may explain subsequent growth failure.
24
Hansen, Bridget J. "Small Business Growth and Non-Growth over the Long-term." Thesis, University of Canterbury. Management, 2009. http://hdl.handle.net/10092/2363.
Повний текст джерелаАнотація:
This study investigates the growth and non-growth of small-and-medium-sized enterprises (SMEs) over the long-term. A multiple case study methodology was used to examine the growth paths of eight SMEs over a period of fourteen years. Four firms represented manufacturing and four, the professional and business services industry. The firms were paired according to similar sectors and contrasting growth paths. Longitudinal employment data illustrated the firms’ growth paths, and the primary method of data collection was semi-structured interviews of the firms’ owner-managers. The research incorporated extensive literature, including traditional research approaches and life cycle models and emergent literature on organisational learning and growth paths.
The growth and non-growth firms were found to be distinct from each other, regardless of industry. The growth firms’ owner-managers had strong growth ambitions and actively sought the recognition and challenges that arise from the operation of multiple growth businesses. The non-growth owner-managers had passive growth ambitions and focused on maintaining their accustomed lifestyle. These differences were also illustrated in the firms’ approaches to networking, internationalisation and technological advancement. The growth firm owner-managers were all portfolio entrepreneurs and had strong professional networks, which they considered were strategically vital. In contrast, the non-growth owner-managers were novice entrepreneurs and were nonchalant towards networking. Innovation and flexibility were identified as important characteristics in the long-term performance of the firms. Findings also indicated that owner-managers’ perceptions of their external business environment determined the influence it had on the business. Individual and collective learning processes underpin these findings in determining long-term growth performance of the firms. The strong interrelationships between owner-managers, learning processes, and longitudinal growth paths suggest areas of future research.
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Clark, Amanda. "Growth Plate Regeneration Using Polymer-Based Scaffolds Releasing Growth Factor." UKnowledge, 2013. http://uknowledge.uky.edu/cbme_etds/12.
Повний текст джерелаАнотація:
Currently growth plate fractures account for nearly 18.5% of fractures in children and can lead to stunted bone growth or angular deformation. If the body is unable to heal itself a bony bar forms, preventing normal bone growth. Clinical treatment involves removing the bony bar and replacing it with a filler substance, which causes poor results 60% of the time.
Using primarily poly(lactic-co-glycolic acid) (PLGA) as the scaffold material, the goal was to develop an implant that would support to the implant site, allow for cell ingrowth, and degrade away over time. Porous scaffolds were fabricated from PLGA microspheres using the salt leaching method. The first part of this work investigated the effect of sintering the microspheres by studying the mechanical properties, degradation and morphology and their potential applications for hard and soft tissue implants. Growth factor or drugs can be encapsulated into PLGA microspheres, which was the second part of this work. Encapsulated insulin-like growth factor I (IGF-I) was able to withstand the scaffold fabrication process without compromising it’s bioactivity and promoted cell proliferation.
The next part of this work experimented with the addition of a hydrogel porogen. Porogen particles were made using a quick degrading poly(beta-amino ester) (PBAE) hydrogel and loaded with ketoprofen. The addition of the porogen creates a dual drug-releasing scaffold with a localized delivery system.
The final step of this work involved animal studies to determine the effectiveness of the scaffolds in growth plate regeneration and how they compare to the current clinical treatment option. Gross observation, microCT analysis, angular measurement of bone growth and histological methods were employed to evaluate the scaffolds.
The goal was to develop a versatile scaffold that could be used for a wide range of tissue engineering applications. The mechanical properties, degradation profiles and drug delivery capabilities can be all tailored to meet the specific needs of an implant site. One specific application was regenerating the native growth plate that can also encourage the endogenous mesenchymal stem cells to follow the desire linage. By regenerating the native growth plate, angular deformation and stunted limb growth were greatly reduced.
26
Wing-Keung, Lo Kenneth. "Export growth, economic growth and real exchange rate in Indonesia." Thesis, City University London, 2000. http://openaccess.city.ac.uk/8120/.
Повний текст джерелаАнотація:
The thesis studies the export growth, economic growth and real exchange rate in Indonesia. The research is a piece of empirical studies mainly covering the period from 1974 to 1993. Indonesia is an oil-exporting country. Economic recession with high inflation rate in the early eighties prompted the government to undertake a series of economic and financial reforms. It was believed that oil export earnings by itself could not sustain long-term economic growth. Trade reform and devaluation would stimulate high economic growth through diversifying non-oil exports, attracting foreign and domestic capital accumulation. The research presented is a contribution to the study of the linkage between export trade and economic growth on one hand, and export trade and real exchange rate on the other hand in Indonesia. In particular, five issues are examined: 1) The role of export growth in economic development. Export growth may boost a country's demand for output and hence cause higher economic growth. It may also increase economic efficiency through economies of scale and liberalization of exchange control; 2) The issue of export-growth can be extended to the argument of export-led growth hypothesis. The hypothesis states that the continuation of merchandise exports would lead to higher output growth. We examine the validity of the hypothesis in the context of the Indonesian export growth economy; 3) To investigate whether export growth is negatively related to real effective exchange rate volatility by the use of cointegrated VAR approach. Policies to minimize exchange rate volatility reduce unfavourable effects on the volume of exports; 4) Since real exchange rate is an important determinant of exports, its behaviour would be worth examining. We particularly examine whether it is stationary by looking at the theory of purchasing power parity. The nonrejection of the purchasing power parity hypothesis implies stationarity of the real exchange rate; 5) Finally, we examine whether the real exchange rate of Indonesia and that of its trading partners share a common trend. This will be an indication that they can form a common currency area. The idea is incorporated into the theory of generalized purchasing power parity. A common currency policy might therefore contribute to intra- and inter-regional trade in the region of Pacific Rim. Hence the research may shed more insight on economic development in one of the less developing countries.
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Porteous, C. "Epidermal growth factor, α-transforming growth factor and breast cancer". Thesis, University of Aberdeen, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383650.
Повний текст джерелаАнотація:
Evidence exists that epidermal growth factor (EGF) and alpha transforming growth factor (αTGF) are important in breast cancer. An inverse relationship between epidermal growth factor receptor (EGF-R) and oestrogen receptor (ER) has been reported by some, (1) but not all workers (2). The aim in this thesis was to develop assays to measure, levels of EGF, and determine EGF-R status in human breast tumours. These results were then correlated with each other, with ER and node status and histological grade (Bloom & Richardson). An additional aim in this thesis was to develop a source of αTGF in conditioned median (CM) from a transformed cell line. After extraction and purification, the αTGF was intended for use as an immunogen to produce a polyclonal antiserum which could be used in either an RIA or ELISA. EGF was measured by a radioimmunoassay (RIA) utilising a rabbit antimouse EGF antiserum. This assay (sensitivity 0.1ng/ml) was demonstrated to have no cross reactivity with αTGF. The EGF-R assay was similar to that described by Sainsbury. (1) In a series of 88 human breast tumours 47 (53.4%) were found to contain extractable EGF. Forty eight (54.5%) were EGF-R positive and 39 (44.3%) were ER positive. A direct relationship between EGF and ER+ ve status was found (p < 0.01). Significantly higher levels of EGF were extracted from ER+ ve tumours (p = 0.049) compared with that from ER-ve tumours. However no relationship between EGF-R and EGF or ER status was found, or between EGF levels and histological grade or node status. A suitable cell line which produced αTGF, was obtained and culture conditions optimised. Alpha-TGF was assayed by a radioreceptor assay which utilised a cell line rich in EGF-R (A431). Extraction of αTGF was based on the principles of molecular grading by gel filtration (Sephadex G50), and ion exchange (Sephadex CM C25). By this process the αTGF was purified and separated it from any EGF present. By this method 20μg of αTGF was produced from 61t of CM. 1) Sainsbury JRC, Farndon JR, Serbet GV, Harris AL. Epidermal-growth-factor-receptors and oestrogen receptors in human breast cancer. Lancet 1985; 1: 364-368. 2) Fitzpatrick SL, Brightwell J, Wattliff JL, Barrows GH, Schultz GS. Epidermal growth factor binding by breast tumour biopsies and relationship to oestrogen receptor and progestin receptor levels. Cancer Res 1984; 44: 3448-3453.
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Holmes, Robert. "The maternal insulin-like growth factor system and fetal growth." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265467.
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Kananagh, A. "The crystal growth and crystal growth inhibition of calcium carbonate." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383820.
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Sundström, Gema, and Guha Kashyap. "CEMenting Growth : Customer Experience Management as a driver of Growth." Thesis, Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-31490.
Повний текст джерелаАнотація:
Purpose: The purpose of this study is the purpose of this study is to gain a more in-depth understanding of customer experience management and how it enables growth within an organization. Background: Customer Experience Management has been described as a process where the entire experience of a customer with a product/service and a company is strategically managed. It has been highlighted as a key area for organisations to focus on, yet, CEM is continuously being researched both by researchers and business practitioners as there is still a vague understanding on the topic. Nonetheless, CEM has been displayed as a successful process, however, very little research has gone into showing that it could enable organizational growth.
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Kampman, Kimberly A. "The insulin-like growth factors in intrauterine growth retarded swine /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487759914760326.
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Kind, Karen Lee. "Insulin-like growth factors and growth of the fetal sheep /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phk525.pdf.
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Konukoğlu, Ender. "Modeling glioma growth and personalizing growth models in medical images." Nice, 2009. http://www.theses.fr/2009NICE4000.
Повний текст джерелаАнотація:
Les modèles mathématiques et plus spécifiquement les modèles basés sur l’équation de réaction-diffusion ont été utilisés largement dans la littérature pour modéliser la croissance des gliomes cérébraux et des tumeurs en général. De plus la grande littérature de recherche qui concentre sur les expériences biologiques et microscopiques, récemment les modèles ont commencé intégrer l’imagerie médicale dans ses formulations. Incluant la géométrie du cerveau et celle de la tumeur, les structures des différentes tissues et la direction de diffusion, ils ont montré qu’il est possible de simuler la croissance de la tumeur comme c’est observé dans les images médicales. Bien que des modèles génériques ont été proposés, les méthodes pour adapter ces modèles aux images d’un patient reste un domaine inexploré. Dans cette thèse nous nous adressons au problème de ‘personnalisation de modèle mathématique de la croissance de tumeurs’. Nous nous focalisons sur les modèles de réaction-diffusion et leurs applications sur la croissance des gliomes cérébrales. Dans la première étape, nous proposons une méthode pour l’identification automatique des paramètres ‘patient-spécifiques’ du modèle à partir d’une série d’images. En observant la divergence entre la visualisation des gliomes dans les IRMs et les modèles réaction-diffusion, nous déduisons une nouvelle formulation pour expliquer l’évolution de la délinéation de la tumeur. Ce modèle ‘Eikonal anistropique modifié’ est utilisé plus tard pour l’estimation des parame��tres à partir des images. Nous avons théoriquement analysé la méthode proposée à l’aide d’un base donne synthétique et nous avons montré la capacité de la méthode et aussi sa limitation. En plus, les résultats préliminaires, sur les cas réels montrent des potentiels prometteurs de la méthode d’estimation des paramètres et du modèle de réaction-diffusion pour la quantification de la croissance de tumeur et aussi pour la prédiction de l’évolution futur de la tumeur. En suivant la personnalisation, nous nous concentrons sur les applications cliniques des modèles ‘patient-spécifiques’. Spécifiquement, nous nous attaquons au problème de la visualisation limitée d’infiltration de gliome dans l’IRM. En effet, les images ne montrent qu’une partie de la tumeur et masquent l’infiltration basse-densité. Cette information absente est cruciale pour la radiothérapie et aussi pour d’autre type de traitements. Dans ce travail, nous proposons pour ce problème une formulation basée sur les modèles ‘patient-spécifiques’. Dans l’analyse de cette méthode nous montrons également les bénéfices potentiels pour la planification de la radiothérapie. La dernière étape de cette thèse se concentre sur les méthodes numériques de l’équation ‘Eikonal anisotropique’. Ce type d’équation est utilisé dans beaucoup de problèmes différents tel que la modélisation, le traitement d’image, la vision par ordinateur et l’optique géométrique. Ici nous proposons une méthode numérique rapide et efficace pour résoudre l’équation Eikonal anisotropique. En la comparant avec une autre méthode état-de-l’art nous démontrons les avantages de la technique proposéeMathematical models and more specifically reaction-diffusion based models have been widely used in the literature for modeling the growth of brain gliomas and tumors in general. Besides the vast amount of research focused on microscopic and biological experiments, recently models have started integrating medical images in their formulations. By including the geometry of the brain and the tumor, the different tissue structures and the diffusion images, models are able to simulate the macroscopic growth observable in the images. Although generic models have been proposed, methods for adapting these models to individual patient images remain an unexplored area. In this thesis we address the problem of “personalizing mathematical tumor growth models”. We focus on reaction-diffusion models and their applications on modeling the growth of brain gliomas. As a first step, we propose a method for automatic identification of patient-specific model parameters from series of medical images. Observing the discrepancies between the visualization of gliomas in MR images and the reaction-diffusion models, we derive a novel formulation for explaining the evolution of the tumor delineation. This “modified anisotropic Eikonal model” is later used for estimating the model parameters from images. Thorough analysis on synthetic dataset validates the proposed method theoretically and also gives us insights on the nature of the underlying problem. Preliminary results on real cases show promising potentials of the parameter estimation method and the reaction-diffusion models both for quantifying tumor growth and also for predicting future evolution of the pathology. Following the personalization, we focus on the clinical application of such patient-specific models. Specifically, we tackle the problem of limited visualization of glioma infiltration in MR images. The images only show a part of the tumor and mask the low density invasion. This missing information is crucial for radiotherapy and other types of treatment. We propose a formulation for this problem based on the patient-specific models. In the analysis we also show the potential benefits of such the proposed method for radiotherapy planning. The last part of this thesis deals with numerical methods for anisotropic Eikonal equations. This type of equation arises in both of the previous parts of this thesis. Moreover, such equations are also used in different modeling problems, computer vision, geometrical optics and other different fields. We propose a numerical method for solving anisotropic Eikonal equations in a fast and accurate manner. By comparing it with a state-of-the-art method we demonstrate the advantages of our technique
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Kazeminia, Ali. "Firm Sustained Growth." Doctoral thesis, Universitat Ramon Llull, 2015. http://hdl.handle.net/10803/301631.
Повний текст джерелаАнотація:
Aquesta tesi respon a la pregunta de “Com les empreses creixen de forma sostenible en contexts dinàmics”, una de les qüestions fonamentals de la literatura d’estratègia. La tesi està formada per tres estudis que aborden diferents aspectes del creixement d´una empresa.
El primer estudi proporciona un anàlisi teòric sobre “com” es produeix el creixement utilitzant la perspectiva “open-systems” i “resource-based view”. Bàsicament descriu com els recursos de les empreses creixen, i clarifica les característiques del creixement. L’estudi finalitza amb una discussió sobre la heterogeneïtat dels recursos de les empreses.
El segon estudi aporta un recolzament empíric al primer estudi i descriu el creixement sostingut del consorci Airbus durant un període de 20 anys (entre 1967 i 1986). L’estudi mostra com la acumulació incremental de recursos centrada en l’estratègia de “comunalitat” ha contribuït al creixement sostenible d’Airbus. A més a més, l’estudi mostra dos períodes de creixement (1) la creació i establiment durant la primera dècada i (2) altres avanços tecnològics posteriors.
Finalment, el darrer estudi aporta una teoria sobre el trencament inesperat d´una aliança i com aquest interromp el creixement de la empresa, on el divorci dirigeix l’empresa a una crisi. L’article argumenta com l’empresa pot superar la crisi i tornar a les condicions de creixement a través de la gestió dels seus recursos. L’estudi presenta com la velocitat de canvi dels recursos pot contribuir a la gestió dels recursos en crisi.Esta tesis responde a la pregunta “¿cómo pueden crecer de forme sostenible las empresas en contextos dinámicos?”, que es una de las cuestiones fundamentales en la literatura de estrategia. La tesis está formada por tres estudios sobre varios aspectos del crecimiento de las empresas. El primer estudio presenta un estudio teórico sobre “cómo” se produce el crecimiento de empresa utilizando la perspectiva de “open-systems” y “resource-based view”. Básicamente describe cómo los recursos crecen y clarifica las características de ese crecimiento. El estudio finaliza con una discusión sobre la heterogeneidad de los recursos de las empresas. El segundo estudio aporta un estudio empírico sobre el tema tratado en el primer artículo y describe el crecimiento sostenible del consorcio Airbus a lo largo de 20 años (entre 1967 y 1986). El estudio muestra cómo la acumulación incremental de recursos centrada en la estrategia de “comunalidad” ha contribuido al crecimiento sostenido de Airbus. Además, el estudio presenta dos períodos de crecimiento: (1) la creación y establecimiento durante la primera década, y (2) otros avances tecnológicos posteriores. Finalmente, el último estudio ofrece una teoría sobre la terminación inesperada de una alianza y cómo ésta interrumpe el crecimiento de la empresa, donde el divorcio lleva la empresa a la crisis. El artículo argumenta cómo la empresa puede superar la crisis y volver a las condiciones de crecimiento a través de la gestión de sus recursos. El estudio presenta cómo la velocidad de cambio de los recursos puede contribuir a la gestión de los recursos en crisis.
The thesis responds to the question ´how do firms grow sustainably in dynamic environments´ as one of the fundamental questions in strategy literature. It provides three concrete studies in addressing various aspects of firm´s growth: the first study provides a theoretical study on the how of firm growth drawing on open-system perspective and resource-based view. It basically describes how firm´s resources grow and clarifies the characteristics that resources show over time. The study is finalized by discussions on the heterogeneity of firms´ resources. The second study provides an empirical support for the first study and provides an empirical case on the successful and sustained growth of Airbus consortium over 20 years from 1967 to 1986. The study shows how the incremental accumulation of resources with a focus on commonality strategy has contributed to the sustained growth of Airbus. In addition, the study shows two periods of growth (1) sparks and establishment in the first decade of Airbus growth and (2) further technological advances afterwards. Finally, the last study provides a theory of an unexpected dissolved alliance interrupting the firm growth where the divorce directs the firm into crisis. It discusses how the firm can pass the crisis and return to its growth condition through the management of its resources. The study discusses how the change speed of resources could contribute to the management of resources in crisis.
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Prähofer, Michael. "Stochastic Surface Growth." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-13818.
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Palm, Oskar. "Bacterial growth models." Thesis, KTH, Teoretisk fysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-44034.
Повний текст джерелаАнотація:
In this thesis the growth patterns of certain bacterial colonies are studied through numerical simulations of a continuous model, describing the growth of the colony. The objective was to construct a mathematical model capable of recreating observed growth patterns and thus try to gain some insight into the dynamics of bacterial growth. The model constructed in this thesis consists of a set of reaction-diffusion equations describing the evolution of the bacterial colony viewed as a continuous body rather than many individual bacteria. This approach was partially successful, in the sense that similar patterns to those observed in experiments were indeed observed in the simulations. On the other hand, the model was found inadequate in the sense that it could not satisfactory account for the initial rapid expansion of the colony in combination with the fact that the expansion is severely diminished after a few days. From the results it could be concluded that in order to get a satisfactory description of the complete evolution of the bacterial colonies studied here a more sophisticated theory for the diffusion processes is needed. The main conclusion is that the changes in the growth patterns are most likely due to genetic changes, or ’mutations’, in some bacteria causing the mutated bacteria to diffuse faster. There is an upper bound for the mutation frequency in order to get the patterns seen in experiments. The biological mechanism behind this phenomenon could be that the bacteria that mutate lose their pili enabling them to diffuse faster.
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Conlon, Ian John. "Cell growth control." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252019.
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Voitchovsky, Sarah. "Inequality and growth." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670079.
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Ghazi, Faezeh. "Corruption and Growth." Bowling Green State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1410522823.
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Zhang, Wei. "Growth of phosphorene." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS140.
Повний текст джерелаАнотація:
Au cours de la dernière décennie, la recherche sur les matériaux 2D a considérablement progressé en raison de leurs nouvelles propriétés jusqu'alors inconnues et de leurs potentielles applications en électronique et optoélectronique de nouvelle génération. En particulier, le phosphorène a récemment suscité un vif intérêt car il possède plusieurs propriétés qui le distinguent des autres matériaux 2D. En effet, il présente une bande interdite intrinsèque accordable, qui peut varier de 1,8 eV pour une monocouche atomique à 0,35 eV pour un cristal de phosphore noir, avec une grande mobilité des porteurs et un rapport ON/OFF élevé. Tous ces attributs rendent le phosphorène parfaitement adapté aux applications électroniques et optoélectroniques à l'échelle nanométrique.Inspiré par la recherche réalisée sur le phosphorène noir, une nouvelle structure allotropique 2D du phosphore, le phosphorène bleu, a été théoriquement prédite. Cette structure est en nids d'abeilles et partage de nombreuses caractéristiques avec le phosphorène noir. La synthèse du phosphorène est basée principalement sur les techniques d’exfoliations du phosphore noir. Cependant, la synthèse contrôlée du phosphorène basée sur des processus industriels tels que la croissance par jets moléculaires ou le dépôt chimique en phase vapeur reste un défi majeur pour une intégration future dans des applications industrielles.Dans cette thèse, on présente une étude expérimentale de la croissance du phosphore sur un substrat d’Au(111) et d’Ag(111). Les expériences ont été réalisées en utilisant les techniques ultravides suivantes : la microscopie et la spectroscopie à effet tunnel (STM-STS), la diffraction d’électrons lents (LEED), la spectroscopie d’électrons Auger (AES), la spectroscopie de photoélectrons (XPS) et la photoémission résolue en angle (ARPES).Dans le chapitre 1, on présentera l’état de l’art de la synthèse du phosphorène.Dans le chapitre 2, on décrira les bases des techniques expérimentales utilisées dans cette thèse.Dans le chapitre 3, on présentera la croissance du phosphore sur une surface d’Au(111). Les images de microscopie à effet tunnel montrent une couche ordonnée du phosphorène bleu alors que les mesures ARPES montrent une valeur du gap au moins égale à 0.8 eV. La réactivité du phosphorène sur la surface d’Au(111) a aussi été étudiée en fonction de la température et nous avons mis en évidence un processus de substitution des atomes d’or avec les atomes de phosphore.Dans le chapitre 4, on présentera la croissance du phosphore sur une surface d’Ag(111). Les images STM montrent une structure 2D du phosphore constituée de pentamères auto-organisés alors que les mesures STS montrent un gap de 1.2 eV. Le dépôt du phosphore donne lieu aussi à la formation de nano-rubans auto-organisés avec un gap de 1.8 eV. Finalement, le dépôt du phosphore à haute température donne lieu la formation d’ilôts monoatomiques auto-organisés.Dans le derrière partie on présentera une conclusion ainsi qu’une perspective de cette étudeOver the last decade, the research in 2D materials has grown appreciably, due to their new hitherto unknown properties as well as their great promise for application in next generation electronic and optoelectronic devices. In particularly, phosphorene has recently attracted intensive interest because it has several properties that distinguish it from other 2D materials, including an intrinsic direct band gap, that can be tuned from 1.8 eV for a monolayer to 0.35 eV for bulk black phosphorus crystals, and high carrier mobility with high on/off ratio. All these attributes make it suitable for nano-scale devices.Inspired by the investigation of black phosphorene, a new attractive 2D phosphorus allotrope, blue phosphorene, has been predicted theoretically, which shares many excellent characteristics as black phosphorene with the buckled honeycomb lattice. So far, phosphorene is obtained by exfoliation of black phosphorus. The controlled synthesis of phosphorene, based on industrial processes such as MBE and chemical vapor deposition (CVD), is still a major challenge for further applications.In this thesis, we present an experimental investigation of the epitaxial growth of phosphorus on Au(111) and Ag(111) substrates. The experiments were performed using the following ultra-high vacuum surface science techniques: scanning tunneling microscopy and spectroscopy (STM-STS), low energy electron diffraction (LEED), Auger electron spectroscopy (AES), X-ray photoelectron spectroscopy (XPS) and angle resolved photoemission spectroscopy (ARPES).In chapter 1, we present the state of the art on the synthesis of phosphorene.In chapter 2, we describe the basis of the experimental setup and techniques used in this thesis.In chapter 3, we present the growth of blue phosphorene Au(111). The STM images show an extended and ordered layer of blue phosphorene while the ARPES measurements show that the blue phosphorene presents a band gap of at least 0.8 eV. The reactivity of phosphorus on Au(111) versus the temperature of the substrate is studied and we highlight a substitution process between phosphorus atoms and the topmost Au atoms.In chapter 4, we present the growth of 2D phosphorus structures on Ag(111). The STM images show self-assembled 2D layer of phosphorus pentamers while the STS measurements give a band gap of 1.20 eV. Deposition of Phosphorus induces also self-assembled black phosphorene nanoribbons with a band gap value of 1.8 eV. Finally, deposition of phosphorus at elevated temperature induces a self-assembled phosphorus monoatomic islands.In the last part we present a conclusion with a perspective of this study
41
WANG, QI. "Shrinkage amid Growth." Thesis, KTH, Arkitektur, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-298829.
Повний текст джерелаАнотація:
In general, the project I am going to present has two parts, the first part was finished in my first master year (2020.05) and further improved during past days, while the second part is what I have been focused on during the thesis. together, they worked as a complete circle in the project. From the reality perspective, what caught my attention was the two opposite trends during urban development – growing and shrinking. -The cities in growth nowadays, especially megacities, are facing huge challenges on housing shortages, transportation pressures, overpopulation issues etc. for centuries, while these problems are still unsolved? Why? -The cities in shrinkage are in a totally different scenario, there is no housing shortages, no transportation pressures, no overpopulation issues, but why people are still leaving? My answer to these questions is that some parts of our societal system have been ‘unevolved’ for too long, such as the economical system. In this sci-fi project, I imagined the world after a catastrophe will be provided with a chance to reform……
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Hine, Brooke A. "Growth and Deterioration." VCU Scholars Compass, 2004. http://scholarscompass.vcu.edu/etd/929.
Повний текст джерелаАнотація:
I use porcelain clay because it allows me to focus on the subtle color shifts between white, beige, and gray. The forms I make in clay are associated with tangled roots, naked tree branches, hollow logs, and bones. I reveal this with a dense mass of curvilinear hollow forms that stack into a rhythmic linkage. They twist and turn, relying on gravity to dictate their structure within the installation. The ends of some are closed while others remain open to expose their interior. The tearing and perforations on the surface of each piece are employed to emphasize deterioration. In opposition to the tearing and perforations, I also add concave lines to the surface creating a flowing moving force. The surface is both visually active and smooth, allowing the eye to roam and focus on specific areas. I'm also working with the accumulation of pieces to communicate growth. The individual pieces rest on one another, growing into an interlocking structure. The pedestal is a formal presentation that is specific to the space. For this installation, I wanted to make the work monumental by elevating an accumulation of pieces. When walking around the artwork, there's an opening in the platform for one person to walk in and be surrounded by the two sides of the piece. The work is above eye level and surrounds the viewer at both sides. I want people to view the mass from the outside, but to also have an experience from the inside.
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Drudiková, Dita. "Inflation Growth Relation." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-73333.
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Barrett, Stephen G. "Growth through change." Theological Research Exchange Network (TREN), 1995. http://www.tren.com.
Повний текст джерелаАнотація:
Thesis (D. Min.)--Westminster Theological Seminary, Philadelphia, 1995.Includes tutor's manual: Growth through change in Northern Argentina; and Doctor of Ministry contract. Includes bibliographical references (leaves 269-273).
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Read, Christopher Michael. "Asparagus growth model." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Spring2009/c_read_050409.pdf.
Повний текст джерелаАнотація:
Thesis (M.S. in agriculture)--Washington State University, May 2009.Title from PDF title page (viewed on June 19, 2009). "Department of Crop and Soil Sciences." Includes bibliographical references (p. 26).
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Eberz-Wagner, Dorothea M. "Discrete growth models /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/5797.
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Graves, Stephen James. "Growth of tessellations." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2009. http://wwwlib.umi.com/cr/syr/main.
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VALENTI, FABRIZIO. "Essays on growth." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/203332.
Повний текст джерелаАнотація:
This paper studies the relationship between volatility and growth in an
endogenous growth model with recursive Epstein-Zin preferences. The model
shows that such a relationship crucially depends on the curvature of the utility
function, i.e. on the parameter measuring risk aversion and intertemporal elas
ticity of substitution. In particular, when both these parameters are relatively
high or relatively low, the simulations demonstrate that uncertainty has a neg
ative e⁄ect on growth. Standard expected utility preferences, thus, show that
this relationship is positive since they constrain risk aversion and intertempo
ral elasticity of substitution to be one the inverse of the other. This suggests
that it is preferrable to employ Epstein-Zin preferences to analyse the e⁄ects
of uncertainty on long-term growth
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Padidela, R. N. R. "Effects of polymorphisms in the growth hormone and insulin-like growth factor axis on intrauterine and postnatal growth." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1396005/.
Повний текст джерелаАнотація:
Context: Intrauterine and postnatal growth influences future risks for metabolic syndrome. Body size and blood pressure (BP) are polygenic traits. The role for genetic variations in growth hormone (GH)-insulin-like growth factor (IGF) axis genes on intrauterine and early childhood growth and blood pressure, as well as gene loci identified through Genome Wide Association Studies (GWAS), are unclear. Objective: To determine whether common variations in the genes of the GH-IGF axis associate with antenatal growth and birth size and play a role in the determination of body size and blood pressure at 3 years of age. Study design: Pregnant women from white European families were recruited by the University College London Fetal Growth Study (n = 774). Fetal growth was measured by ultrasonography at each trimester. Postnatal growth data were collected prospectively at 6 months, 1 year, 2 years and 3 years of age. BP was measured at 3 years of age. Genotyping was performed by a combination of restriction fragment length polymorphism analysis, KBioscience Competitive Allele specific PCR genotyping System (KASP) analysis and multiplex polymerase chain reaction (PCR). Results: The GHR exon 3 deletion genotype was significantly associated with birth weight and placental weight. IGF1 SNPs did not demonstrate significant consistent longitudinal association with parameters investigated. IGF2 SNPs were significantly associated with intrauterine growth (rs680), birth weight (rs680), placental weight (rs680) and BP (rs3842759) at 3 years of age. Several SNPs in genes found to be associated with adult BMI and BP from GWAS were significantly associated with early childhood size (MTCH2, SH2B3), body composition (SH2B1, TMEM18) and BP (FTO). Conclusion: These data suggest that several polymorphisms in the GH-IGF axis and in GWAS-identified genes for adult BMI and BP are significantly associated with intrauterine and early childhood size and BP at 3 years of age.
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Sia, Vicente Y. "Factors affecting church growth in selected Filipino-Chinese churches." Online full text .pdf document, available to Fuller patrons only, 2004. http://www.tren.com.
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