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1

Jackson, Bill, Tibor Jordan, and Zoltan Szabadka. "Globally Linked Pairs of Vertices in Equivalent Realizations of Graphs." Discrete & Computational Geometry 35, no. 3 (January 20, 2006): 493–512. http://dx.doi.org/10.1007/s00454-005-1225-8.

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2

Ramanathan, Tara, Nithya Ramanathan, Jeevan Mohanty, Ibrahim H. Rehman, Eric Graham, and Veerabhadran Ramanathan. "Wireless sensors linked to climate financing for globally affordable clean cooking." Nature Climate Change 7, no. 1 (October 31, 2016): 44–47. http://dx.doi.org/10.1038/nclimate3141.

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3

Casto, Amanda M., Jun Z. Li, Devin Absher, Richard Myers, Sohini Ramachandran, and Marcus W. Feldman. "Characterization of X-Linked SNP genotypic variation in globally distributed human populations." Genome Biology 11, no. 1 (2010): R10. http://dx.doi.org/10.1186/gb-2010-11-1-r10.

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4

Zhou, Zhichao, Patricia Q. Tran, Kristopher Kieft, and Karthik Anantharaman. "Genome diversification in globally distributed novel marine Proteobacteria is linked to environmental adaptation." ISME Journal 14, no. 8 (May 11, 2020): 2060–77. http://dx.doi.org/10.1038/s41396-020-0669-4.

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5

Schield, Drew R., Elizabeth S. C. Scordato, Chris C. R. Smith, Javan K. Carter, Sidi Imad Cherkaoui, Sundev Gombobaatar, Said Hajib, et al. "Sex‐linked genetic diversity and differentiation in a globally distributed avian species complex." Molecular Ecology 30, no. 10 (March 29, 2021): 2313–32. http://dx.doi.org/10.1111/mec.15885.

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6

Indraprahasta, Galuh Syahbana, Ben Derudder, and Delik Hudalah. "Local institutional actors and globally linked territorial development in Bekasi District: A strategic coupling?" Singapore Journal of Tropical Geography 40, no. 2 (October 28, 2018): 219–38. http://dx.doi.org/10.1111/sjtg.12269.

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7

Kelleher, Tom, and Michelle O'Malley. "Applying the Technology Acceptance Model to Assess Outcomes in a Globally Linked Strategic Communication Project." Journalism & Mass Communication Educator 60, no. 4 (December 2005): 402–14. http://dx.doi.org/10.1177/107769580506000408.

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Анотація:
Public relations students at two U.S. universities separated by several time zones were assigned to use online message boards to communicate with each other as well as cultural consultants in Korea to write an issue statement and promotional plan for an international strategic communications project. The technology acceptance model was found to fit well with student attitudes and behaviors related to online bulletin board systems used in the class project. Student perceptions of the ease of using online technology were the strongest predictors of their intentions to use this technology in their careers beyond the classroom.
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8

Laloë, Jacques-Olivier, Jacquie Cozens, Berta Renom, Albert Taxonera, and Graeme C. Hays. "Climate change and temperature-linked hatchling mortality at a globally important sea turtle nesting site." Global Change Biology 23, no. 11 (June 16, 2017): 4922–31. http://dx.doi.org/10.1111/gcb.13765.

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9

Lightner, Sharon, and Carol Olson Houston. "Offering a globally-linked international accounting course in real time: a sharing of experiences and lessons learned." Journal of Accounting Education 19, no. 4 (December 2001): 247–63. http://dx.doi.org/10.1016/s0748-5751(01)00023-9.

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10

Algosaibi, Abdulelah, Khaled Ragab, and Saleh Albahli. "Parallel-Based Techniques for Managing and Analyzing the Performance on Semantic Graph." Parallel Processing Letters 30, no. 02 (June 2020): 2050007. http://dx.doi.org/10.1142/s0129626420500073.

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Анотація:
In recent years, data are generated rapidly that advanced the evolving of the linked data. Modern data are globally distributed over the semantically linked graphs. The nature of the distributed data over the semantic graph raised new demands on further investigation on improving performance on the semantic graphs. In this work, we analyzed the time latency as an important factor to be further investigated and improved. We evaluated the parallel computing on these distributed data in order to better utilize the parallelism approaches. A federation framework based on a multi-threaded environment supporting federated SPARQL query was introduced. In our experiments, we show the achievability and effectiveness of our model on a set of real-world quires through real-world Linked Open Data cloud. Significant performance improvement has noticed. Further, we highlight short-comings that could open an avenue in the research of federated queries. Keywords: Semantic web; distributed query processing; query federation; linked data; join methods.
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11

Benito-Alifonso, David, Rachel A. Jones, Anh-Tuan Tran, Hannah Woodward, Nichola Smith, and M. Carmen Galan. "Synthesis of mucin-type O-glycan probes as aminopropyl glycosides." Beilstein Journal of Organic Chemistry 9 (September 13, 2013): 1867–72. http://dx.doi.org/10.3762/bjoc.9.218.

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Анотація:
The chemical synthesis of a series of mucin-type oligosaccharide fragments 1–7 containing an α-linked aminopropyl spacer ready for glycoarray attachment is reported. A highly convergent and stereoselective strategy that employs two different orthogonal protected galactosamine building blocks was used to access all of the targets. A tandem deprotection sequence, that did not require chromatography-based purification between steps, was employed to globally unmask all protecting groups and all final targets were isolated in good to excellent yields.
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12

Tijet, Nathalie, David Boyd, Samir N. Patel, Michael R. Mulvey, and Roberto G. Melano. "Evaluation of the Carba NP Test for Rapid Detection of Carbapenemase-Producing Enterobacteriaceae and Pseudomonas aeruginosa." Antimicrobial Agents and Chemotherapy 57, no. 9 (July 1, 2013): 4578–80. http://dx.doi.org/10.1128/aac.00878-13.

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ABSTRACTThe Carba NP test was evaluated against a panel of 244 carbapenemase- and non-carbapenemase-producingEnterobacteriaceaeandPseudomonas aeruginosaisolates. We confirmed the 100% specificity and positive predictive value of the test, but the sensitivity and negative predictive value were 72.5% and 69.2%, respectively, and increased to 80% and 77.3%, respectively, using a more concentrated bacterial extract. False-negative results were associated with mucoid strains or linked to enzymes with low carbapenemase activity, particularly OXA-48-like, which has emerged globally in enterobacteria.
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13

Lew, Charlotte. "Promoting Vanderbilt Divinity Publications on Wikidata." TCB:Technical Services in Religion & Theology 30, no. 1 (January 26, 2022): 1–8. http://dx.doi.org/10.31046/tcb.v30i1.3039.

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This article introduces the operations of Wikidata and WikiCite to theological librarians in technical services roles. To familiarize potential editors with these operations, the Vanderbilt Wikidata and WikiCite team offers a training program, Learn Wikidata. Through the training, librarians from divinity schools or local seminaries will be equipped to add institutional publications to a multilingual platform structed with linked data that presents and shares information globally. Participation in WikiCite and Wikidata can elevate faculty’s reputation of their digital scholarship and increase visibility and accessibility of their works.
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14

Accornero, Guya, Mona Harb, Alex F. Magalhães, Felipe G. Santos, Giovanni Semi, Samuel Stein, and Simone Tulumello. "‘Stay Home Without a Home’: Report from a webinar on the right to housing." Radical Housing Journal 2, no. 1 (May 4, 2020): 197–201. http://dx.doi.org/10.54825/kbiz8649.

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This Update reports from a webinar on the impacts on the right to housing and linked political struggles of the lockdown measures put in place globally amid the Covid-19 pandemic. Three main threads emerged through the conversation: the impacts of the pandemic are deepening pre-existing housing inequalities, while governments’ responses are largely insufficient; activists and contentious actors worldwide are changing their framings and repertoires to adapt to lockdown measures and attempt to radicalise their action; possibilities, albeit limited, are opening for the construction of global networks of struggle.
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15

Jensen, Eric Allen. "A conceptual framework for monitoring socially responsible research and innovation (RRI) aligned to the UNESCO-led Recommendation on Science and Scientific Researchers." Open Research Europe 2 (February 14, 2022): 21. http://dx.doi.org/10.12688/openreseurope.14263.1.

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Анотація:
This paper sets out a high-level conceptual framework for monitoring the development of socially responsible research and innovation systems linked to the global policy instrument called ‘the Recommendation on Science and Scientific Researchers’ (RSSR). This global science policy initiative was ratified by 195 United Nations Educational Scientific and Cultural Organization (UNESCO) Member States in 2017, updating an earlier version of the instrument. This UNESCO-led initiative offers a globally inclusive and agreed structure for advancing socially responsible research and innovation (RRI). A key feature of the RSSR initiative is its permanent structure of quadrennial monitoring to assess implementation of its principles. Here, a conceptual framework is presented to clarify the specific dimensions of RRI embedded in the 10 key priority areas for this quadrennial monitoring process. The paper explicates these dimensions and the underpinning policy language from the 2017 recommendation with the aim of supporting UNESCO Member States and research stakeholders globally to design appropriate evaluation methods. This conceptual framework is intended to support development of globally aligned measurement of RRI policy and practice that allows research and policy stakeholders from each world region to learn from each other. Fostering mutual learning on a global scale will help to enable evidence-based practice in the context of RRI to improve outcomes and mitigate the limitations of well-meaning but ineffective policies and practices.
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16

Su, Xin-Tong, Lu Wang, Si-Ming Ma, Yan Cao, Na-Na Yang, Lu-Lu Lin, Marc Fisher, Jing-Wen Yang, and Cun-Zhi Liu. "Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke." Oxidative Medicine and Cellular Longevity 2020 (October 24, 2020): 1–15. http://dx.doi.org/10.1155/2020/7875396.

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Ischemic stroke is the major type of cerebrovascular disease usually resulting in death or disability among the aging population globally. Oxidative stress has been closely linked with ischemic stroke. Disequilibrium between excessive production of reactive oxygen species (ROS) and inherent antioxidant capacity leads to subsequent oxidative damage in the pathological progression of ischemic brain injury. Acupuncture has been applied widely in treating cerebrovascular diseases from time immemorial in China. This review mainly lays stress on the evidence to illuminate the possible mechanisms of acupuncture therapy in treating ischemic stroke through regulating oxidative stress. We found that by regulating a battery of molecular signaling pathways involved in redox modulation, acupuncture not only activates the inherent antioxidant enzyme system but also inhibits the excessive generation of ROS. Acupuncture therapy possesses the potential in alleviating oxidative stress caused by cerebral ischemia, which may be linked with the neuroprotective effect of acupuncture.
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17

Little, Sabine. "Great Aunt Edna’s Vase: Metaphor Use in Working With Heritage Language Families." Family Journal 27, no. 2 (March 3, 2019): 150–55. http://dx.doi.org/10.1177/1066480719833417.

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Анотація:
This article explores the use of a particular metaphor—Great Aunt Edna’s Vase—as a means to facilitating multilingual families in contextualizing and engaging with complex emotional connections as linked to language, identity, and belonging. Building from the premise that language is linked to the construction of identity, but that individual family members will have different views and opinions on the heritage language within this context, this article highlights the use of metaphors in family work, before introducing the metaphor of Great Aunt Edna’s Vase and situating it in relevant literature around language, heritage, and identity. The concepts introduced add to the existing body of literature in addressing the growing need for work specifically aimed at multilingual families, in a globally ever-more-diverse society, highlighting the links between language and well-being, and making a contribution to the global knowledge necessary for practitioners and families to explore these links successfully.
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18

Onohara, Noriko. "Japan as fashion: Contemporary reflections on being fashionable." Acta Orientalia Vilnensia 12, no. 1 (January 1, 2011): 29–41. http://dx.doi.org/10.15388/aov.2011.0.1095.

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Анотація:
University of HyogoThis paper examines how Japanese contemporary fashion has been accepted globally, especially in the case of London. The popularity of Japanese fashion in the West started in the 19th century with kimono-style dressing gowns, but for the true design influence known as Japan-shock, we had to wait for the appearance of the avantgarde Japanese fashion designers who participated in the Paris collection in the 1970s and 1980s. A new keyword for ‘fashionable Japan’ today is kawaii, the notion of cute. This is intimately linked to street fashion and subculture and has been established and received as part of ‘cool Japan’ through the worldwide popularity of Japanese manga and anime. Moreover, it could be said that Japan is fashionable and the Japanese are thought of as fashionable people, but who is described as fashionable, and by whom? To reflect upon this statement, ‘the Japanese are fashionable’, as ideology, picking up the globally popular Japanese street fashion magazine FRUiTS, I would like to investigate the double meaning of fashion in the present and also what it means to be fashionable.
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19

Kurincová, Viera, and Anna Klimentová. "Internationalization of Universities and Teacher Preparation for the 21st Century." International Journal on Language, Literature and Culture in Education 3, no. 2 (November 1, 2016): 127–40. http://dx.doi.org/10.1515/llce-2016-0014.

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AbstractThe living in 21st century’s global world has a great impact on various aspects of life in interdependent society. Teachers and educators are expected to be well prepared to teach in classrooms characterized by diversity in culture, language, abilities and other characteristics of pupils. The other challenge for teachers is to support development of new competences of pupils, competences, which enable them to understand global world and to be active participants in new living conditions. The task of teacher training institutions is to find the ways how to prepare globally competent teachers, as their training as well as a real educational practice has always been connected to the existing socio-historical context. The authors of presented paper pointed out some issues linked to the global competence of teachers and the requirements of globally competent students. The paper is focused on the importance of internationalization of future teachers’ preparation. Based on collected empirical data, the authors present possible ways, outcomes and benefits of international study stays of students (prospective teachers) for their professional growth, teachers’ competences and personal development.
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20

Mahant, V. "Multifaceted Medical and Scientific Approaches and the Role of the Public in Combating the COVID-19 Pandemic in the Digital Era." Journal of Biomedical Research & Environmental Sciences 2, no. 1 (January 11, 2021): 008–10. http://dx.doi.org/10.37871/jbres1179.

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Epidemics and pandemics have been recurrent in history. One of the worst pandemics in the modern history was the 1918 H1N1 flu (“Spanish flu”) that claimed the lives of an estimated 50 million people globally [1]. The current pandemic, a severe acute respiratory syndrome coronavirus (SARS-CoV-2), the etiologic agent of COVID-19, was first reported in the city of Wuhan (China) in December 2019. According to the World Health Organization (WHO), at the time of writing, there were over 84 million confirmed cases and over 1.8 million deaths in 218 countries linked to COVID-19 [2], and the numbers of cases continue to climb globally. The viral transmission has been reported as predominantly horizontal while reports of vertical transmission have been limited [3]. The impact of COVID-19 on morbidity, mortality, lifestyle changes, and trillions of dollars in the economy is unprecedented in the modern history. There are significant synergies and a concerted role for multifaceted medical and scientific approaches to be utilized to engage the public in combating COVID-19 effectively.
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21

Dall'Amico, M., S. Endrizzi, S. Gruber, and R. Rigon. "An energy-conserving model of freezing variably-saturated soil." Cryosphere Discussions 4, no. 3 (August 11, 2010): 1243–76. http://dx.doi.org/10.5194/tcd-4-1243-2010.

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Abstract. In this paper we provide a method for solving the energy equation in freezing soil. The solver is linked with the solution of Richards equation, and therefore able to approximate water movement near the liquid-solid phase transition. The equations show non-linear characteristics causing oscillatory behavior in the solution close to the phase transition, when normal methods of iterative integration, as Newton or Picard, are used. Thus, a globally convergent Newton method has been implemented to achieve convergence. The method is tested by comparison with an analytical solution to the Stefan problem and by comparison with experimental data derived from literature.
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22

Nelson, Kristin N., Samuel M. Jenness, Barun Mathema, Benjamin A. Lopman, Sara C. Auld, N. Sarita Shah, James C. M. Brust, et al. "Social Mixing and Clinical Features Linked With Transmission in a Network of Extensively Drug-resistant Tuberculosis Cases in KwaZulu-Natal, South Africa." Clinical Infectious Diseases 70, no. 11 (July 12, 2019): 2396–402. http://dx.doi.org/10.1093/cid/ciz636.

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Abstract Background Tuberculosis (TB) is the leading infectious cause of death globally, and drug-resistant TB strains pose a serious threat to controlling the global TB epidemic. The clinical features, locations, and social factors driving transmission in settings with high incidences of drug-resistant TB are poorly understood. Methods We measured a network of genomic links using Mycobacterium tuberculosis whole-genome sequences. Results Patients with 2–3 months of cough or who spent time in urban locations were more likely to be linked in the network, while patients with sputum smear–positive disease were less likely to be linked than those with smear-negative disease. Associations persisted using different thresholds to define genomic links and irrespective of assumptions about the direction of transmission. Conclusions Identifying factors that lead to many transmissions, including contact with urban areas, can suggest settings instrumental in transmission and indicate optimal locations and groups to target with interventions.
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23

Hu, You, Bin Yi, Xin Chen, Lu Xu, Xiaojun Zhou, and Xinguo Zhu. "MiR-223 Promotes Tumor Progression via Targeting RhoB in Gastric Cancer." Journal of Oncology 2022 (January 6, 2022): 1–10. http://dx.doi.org/10.1155/2022/6708871.

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Gastric cancer (GC) is among the most prevalent causes of cancer-related death globally. MiR-223 has been implicated in a variety of cellular mechanisms linked to cancer progression. However, the miR-223 expressions and its function in GC are unknown. We discovered that miR-223 expression was raised in GC tissues in comparison with nearby normal tissues in this investigation. Additionally, multiplied miR-223 expression was strongly linked with TNM stage ( p = 0.022 ), live metastasis ( p = 0.004 ),lymph node metastasis ( p = 0.004 ),and Borrmann type and was associated with an unfavorable prognostic for patients with GC. Furthermore, suppressing miR-223 significantly increased cell death and prevented cell migration and invasion in vitro. Additionally, miR-223 silencing decreased tumor development in vivo. Additionally, we discovered that miR-223 enhanced GC development by specifically targeting RhoB. In summary, our findings reveal that miR-223 increases tumor progression in GC by targeting RhoB, suggesting that it could serve to be a potential biomarker for the prediction of the disease.
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24

Ceia, Vanessa. "Digital Ecosystems of Ideology: Linked Media as Rhetoric in Spanish Political Tweets." Social Media + Society 6, no. 2 (April 2020): 205630512092663. http://dx.doi.org/10.1177/2056305120926630.

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Анотація:
That Twitter is a major form of political mobilization and influence has been well documented. But what is the role of linked media—references to newspapers, photos, videos, and other external sources via URLs—in political Twitter messaging? How are linked references employed as campaign tools and rhetorical devices in messages published by political parties on Twitter? Is there a quantifiable relationship between a party’s ideology and linked media in tweets? With the spread of fake news, threats to a free press, and questioning of the legitimacy of political messaging on the rise globally, the sources on which parties draw to convince voters of their online messaging deserve critical attention. To explore the above questions, this article examines uses of linked media in tweets generated by the official accounts of Spain’s top five political parties during, in the lead-up, and in the immediate aftermath of the Spanish General Elections held on April 28, 2019. Grounded in a corpus of 10,038 tweets collected between March 1 and May 15, 2019, this study quantifies, compares, and critiques how linked media are integrated and remixed into tweets published by the left-leaning Spanish Workers’ Socialist Party (@PSOE), right-wing Popular Party (@populares), left-wing Podemos (@ahorapodemos), neoliberal Citizens (@CiudadanosCs), and far-right Vox (@vox_es) parties. Evidence reveals that each party links to media from somewhat homophilic groups of news outlets, journalists, and public figures, an analysis of which can shed light on how parties construct their digital self-representations, ideological networks of information, and attempt to sway voters.
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25

Echi, Paul Chinedu, and Victoria Chimuanya Ezeala. "The occurrence of heterophyid metacercariae in a stream linked aquatic reservoirs, Southeast Nigeria." Brazilian Journal of Biological Sciences 3, no. 5 (2016): 105. http://dx.doi.org/10.21472/bjbs.030509.

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The study of teleost parasites in an ecologically altered ecosystem through dam construction that evidently facilitate parasitic infections and aggravate public health concerns is essential. The study of stream linked dam showed that Tilapia zillii (Gervais, 1848), Pelmatolapia mariae (Boulenger, 1899) and Clarias gariepinus (Burchell, 1822) form the major fish composition of these reservoirs. They serve important food resource globally especially places bereft of extensive aquaculture practices. Although, knowledge about the gill parasites of P. mariae is inexistent the examined individual P. mariae showed that it had 54% Heterophyes heterophyes infection, C. gariepinus had no parasitic infection whereas T. zillii had a relatively very low Batrachobdelloides spp (1.7%). Besides, the highest DO levels in the dam occasioned by high agitation and floatation the physical factors conditions - pH and DO (> 6 mg.L^-1) had suitable levels for biodiversity.
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26

Woods, Alex J., Don Heppner, Harry H. Kope, Jennifer Burleigh, and Lorraine Maclauchlan. "Forest health and climate change: A British Columbia perspective." Forestry Chronicle 86, no. 4 (July 1, 2010): 412–22. http://dx.doi.org/10.5558/tfc86412-4.

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Анотація:
BC’s forests have already faced two simultaneous, globally significant, epidemics linked to climate change; the Dothistroma needle blight epidemic in NW BC and the massive mountain pine beetle epidemic throughout the BC Interior. Building on these experiences, we have compiled our best estimates of how we believe other forest health agents may behave as climate change continues to influence our forests. We have drawn on literature from around the world but have focused on the situation in BC. We have made management recommendations based on what we have seen so far and what we expect to come.Key words: climate change, forest health, forest insects, forest pathogens, forest management, British Columbia
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27

Huang, Ruixian, Xiaoyan Duan, Jangao Fan, Guangming Li, and Baocan Wang. "Role of Noncoding RNA in Development of Nonalcoholic Fatty Liver Disease." BioMed Research International 2019 (February 26, 2019): 1–9. http://dx.doi.org/10.1155/2019/8690592.

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Анотація:
Nonalcoholic fatty liver disease (NAFLD) is increasing in prevalence globally, but little is known about its specific molecular mechanisms. During the past decade, noncoding RNAs (ncRNAs) have been linked to NAFLD initiation and progression. They are a class of RNAs that play an important role in regulating gene expression despite not encoding proteins. This review summarizes recent research on the relationship between ncRNAs and NAFLD. We discussed the potential applicability of ncRNAs as a biomarker for early NAFLD diagnosis and assessment of disease severity. With further study, ncRNAs should prove to be valuable new targets for NAFLD treatment and benefit the development of noninvasive diagnostic methods.
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28

Chapman, Christopher, Anja Kern, and Aziza Laguecir. "Costing Practices in Healthcare." Accounting Horizons 28, no. 2 (January 1, 2014): 353–64. http://dx.doi.org/10.2308/acch-50713.

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Анотація:
SYNOPSIS The rising cost of healthcare is a globally pressing concern. This makes detailed attention to the way in which costing is carried out of central importance. This article offers a framework for considering the interdependencies between a dominant element of the contemporary healthcare context, i.e., Diagnosis Related Group (DRG) systems, and costing practices. DRG-based payment systems strongly influence costing practices in multiple ways. In particular, setting DRG tariffs requires highly standardized costing practices linked with specific skill sets from management accountants and brings other jurisdictions (e.g., clinical coding) to bear on costing practice. These factors contribute to the fragmentation of the jurisdiction of management accounting.
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29

Fielden, Miles A., Andrew C. Chaulk, Kate Bassett, Yolanda F. Wiersma, Mardon Erbland, Hugh Whitney, and Thomas W. Chapman. "Aedes japonicus japonicus (Diptera: Culicidae) arrives at the most easterly point in North America." Canadian Entomologist 147, no. 6 (February 16, 2015): 737–40. http://dx.doi.org/10.4039/tce.2015.5.

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Анотація:
AbstractAedes japonicus japonicus (Theobald) (Diptera: Culicidae), the Asian bush mosquito, is a keen biter linked to the transmission to humans of a variety of diseases. It has moved significantly from its historical Asian distribution, with its arrival in North America first noted in 1998 in New York and New Jersey, United States of America. Here we report the presence of A. j. japonicus within our collections of mosquitoes in the capital city of the easternmost province in Canada: St. John’s, Newfoundland and Labrador, in 2013. This observation provides further evidence of this mosquito’s ability to significantly expand its geographic range, potentially affecting connectivity between subpopulations globally.
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30

Gangur, Venugopal, and Harini G. Acharya. "The Global Rise and the Complexity of Sesame Allergy: Prime Time to Regulate Sesame in the United States of America?" Allergies 1, no. 1 (September 21, 2020): 1–21. http://dx.doi.org/10.3390/allergies1010001.

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Анотація:
Sesame allergy is a life-threatening disease that has been growing globally with poorly understood mechanisms. To protect sensitive consumers, sesame is regulated in many countries. There were four research goals for this work on sesame allergy: (i) to map the timeline, and the extent of its global rise; (ii) to dissect the complexity of the disease, and its mechanisms; (iii) to analyze the global regulation of sesame; and (iv) to map the directions for future research and regulation. We performed a literature search on PubMed and Google Scholar, using combinations of key words and analyzed the output. Regulatory information was obtained from the government agencies. Information relevant to the above goals was used to make interpretations. We found that: (i) the reports appeared first in 1950s, and then rapidly rose globally from 1990s; (ii) sesame contains protein and lipid allergens, a unique feature not found in other allergenic foods; (iii) it is linked to five types of diseases with understudied mechanisms; and (iv) it is a regulated allergen in 32 advanced countries excluding the USA. We also provide directions for filling gaps in the research and identify implications of possible regulation of sesame in the USA.
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31

Lone, Ayesha, Walid Mottawea, Yasmina Ait Chait, and Riadh Hammami. "Dual Inhibition of Salmonella enterica and Clostridium perfringens by New Probiotic Candidates Isolated from Chicken Intestinal Mucosa." Microorganisms 9, no. 1 (January 13, 2021): 166. http://dx.doi.org/10.3390/microorganisms9010166.

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Анотація:
The poultry industry is the fastest-growing agricultural sector globally. With poultry meat being economical and in high demand, the end product’s safety is of importance. Globally, governments are coming together to ban the use of antibiotics as prophylaxis and for growth promotion in poultry. Salmonella and Clostridium perfringens are two leading pathogens that cause foodborne illnesses and are linked explicitly to poultry products. Furthermore, numerous outbreaks occur every year. A substitute for antibiotics is required by the industry to maintain the same productivity level and, hence, profits. We aimed to isolate and identify potential probiotic strains from the ceca mucosa of the chicken intestinal tract with bacteriocinogenic properties. We were able to isolate multiple and diverse strains, including a new uncultured bacterium, with inhibitory activity against Salmonella Typhimurium ATCC 14028, Salmonella Abony NCTC 6017, Salmonella Choleraesuis ATCC 10708, Clostridium perfringens ATCC 13124, and Escherichia coli ATCC 25922. The five most potent strains were further characterized for their probiotic potential (i.e., sensitivity to antibiotics and tolerance to gastrointestinal physicochemical conditions). Our analyzed lactobacilli strains exhibited some interesting probiotic features while being inhibitory against targeted pathogens.
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32

D‘Apolito, Elisabetta, and Antonia P. Iannuzzi. "Incentive Plans, Pay-for-non-financial Performance and ESG Criteria: Evidence from the European Banking Sector." International Business Research 10, no. 10 (September 25, 2017): 169. http://dx.doi.org/10.5539/ibr.v10n10p169.

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Анотація:
The new regulations of banking compensation following the sub-prime crisis require that incentive plans must be linked not only to performance parameters, but also to non-financial or qualitative metrics related to social value produced by banks. This paper aims to analyze this issue by developing a qualitative rating (ESG-remuneration performance rating) to be used not only to investigate the spread and the diversification of such qualitative indicators, but also to analyze the best practices by banks. At a methodological level, the content analysis approach is adopted. The sample covers all of the “European globally systemically important institutions” (G-SIIs), while the investigation period regards the three-years 2014-2016. The main results are encouraging as they show a good diffusion of qualitative metrics by bank incentive plans; however, the intensive use, synthesized by the “ESG-remuneration performance rating”, is still inadequate. Moreover, the analysis reveal other criticalities linked to the implementation of the balance scorecard and the use of measurement tools in order to quantify the qualitative metrics correctly. (Note 1).
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33

Ostberg, Nicolai P., Mohammad A. Zafar, Bulat A. Ziganshin, and John A. Elefteriades. "The Genetics of Thoracic Aortic Aneurysms and Dissection: A Clinical Perspective." Biomolecules 10, no. 2 (January 24, 2020): 182. http://dx.doi.org/10.3390/biom10020182.

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Анотація:
Thoracic aortic aneurysm and dissection (TAAD) affects many patients globally and has high mortality rates if undetected. Once thought to be solely a degenerative disease that afflicted the aorta due to high pressure and biomechanical stress, extensive investigation of the heritability and natural history of TAAD has shown a clear genetic basis for the disease. Here, we review both the cellular mechanisms and clinical manifestations of syndromic and non-syndromic TAAD. We particularly focus on genes that have been linked to dissection at diameters <5.0 cm, the current lower bound for surgical intervention. Genetic screening tests to identify patients with TAAD associated mutations that place them at high risk for dissection are also discussed.
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34

Boman, Björn. "Cultural amnesia or continuity? Expressions of han in K-pop." East Asian Journal of Popular Culture 6, no. 1 (April 1, 2020): 111–23. http://dx.doi.org/10.1386/eapc_00018_7.

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Анотація:
K-pop content is generally associated with romantic love, immaturity, synchronized dance choreographies, attractive performers and globally fashionable pop music. However, over the last years more variability in regard to lyrics and music, partly linked to increased artistic agency among some entertainment companies, has been manifested. In this article, I have analysed how the cultural concept of han (associated with grief or resentment among Korean people) is expressed among groups and artists like BTS, (G)I-dle and Luna/Jambinai. The findings indicate that han in such discourses, while sometimes implicit rather than explicit, expresses lost love, the transgenerational understanding of Korean grief, or an appeal to the collective feeling of vulnerability among global audiences.
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35

Benício, Ronildo A., Tamilie Carvalho, Maria D. R. Barbosa, Janiella de M. Costa, Felipe C. C. da Silva, and Mariluce G. Fonseca. "Worrying News for Brazilian Caatinga: Prevalence of Batrachochytrium dendrobatidis in Amphibians." Tropical Conservation Science 12 (January 2019): 194008291989262. http://dx.doi.org/10.1177/1940082919892626.

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Анотація:
The chytrid fungus Batrachochytrium dendrobatidis (Bd) has been linked to the declines of more than 500 amphibian species globally. In Brazil, Bd has been identified in several regions but predominantly in the Atlantic Forest. Data on the occurrence of this amphibian pathogen in northeastern Brazil are scarce, specifically from the Caatinga ecoregion, where there is only one study that reports Bd in the region. This study is the first to show a high prevalence of Bd in Caatinga’s species and includes two new records of species infected by Bd: Rhinella granulosa and R. jimi. In addition, we discuss the possibility of amphibian with terrestrial habits serving as potential Bd reservoirs in semiarid climate regions.
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36

Li, Minglan, Clare M. Reynolds, Stephanie A. Segovia, Clint Gray, and Mark H. Vickers. "Developmental Programming of Nonalcoholic Fatty Liver Disease: The Effect of Early Life Nutrition on Susceptibility and Disease Severity in Later Life." BioMed Research International 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/437107.

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Анотація:
Nonalcoholic fatty liver disease (NAFLD) is fast becoming the most common liver disease globally and parallels rising obesity rates. The developmental origins of health and disease hypothesis have linked alterations in the early life environment to an increased risk of metabolic disorders in later life. Altered early life nutrition, in addition to increasing risk for the development of obesity, type 2 diabetes, and cardiovascular disease in offspring, is now associated with an increased risk for the development of NAFLD. This review summarizes emerging research on the developmental programming of NAFLD by both maternal obesity and undernutrition with a particular focus on the possible mechanisms underlying the development of hepatic dysfunction and potential strategies for intervention.
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37

Shehata, Gamal, and Ayub Sheik. "Test Writers’ Perceptions of English Language Tests in Relation to the Common European Framework of Reference (CEFR) at a Saudi Arabian University." International Journal of English Language Education 8, no. 2 (August 24, 2020): 151. http://dx.doi.org/10.5296/ijele.v8i2.17578.

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Анотація:
The CEFR is currently being used globally as a guiding document for specifying the standards of language learning, teaching, and assessment. The university wherein this study takes place, assumes that its internally produced English language tests are CEFR-related because they are based on textbooks which claim affinity with the CEFR. This study investigates the validity of this assumption. The literature review suggests a wealth of studies which link a specific test or exam to the CEFR based on the technical procedures laid out in the Manual for Relating Language Examinations to the CEFR (the Manual). This study has a different approach as it investigates whether the internally produced English language tests at a Saudi Arabian university are linked/related to the CEFR from the perspectives of the academic staff who are responsible for producing the English language tests at the university wherein this study is conducted. As such, this study is situated within an interpretative case study paradigm and uses a mixed method methodology for data collection and analysis. The study showed that all the research participants share the view that the English language exams which they develop are CEFR linked/related because they are based on the learning outcomes of textbooks which, according to the publisher, are CEFR linked. In addition, the contextual issues related to the implementation of the Manual and the CEFR are to be considered. The study presents implications and recommendations for the institution and for ELT publishers who claim that their ELT materials are CEFR linked.
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38

Meehl, Gerald A., Aixue Hu, Julie M. Arblaster, John Fasullo, and Kevin E. Trenberth. "Externally Forced and Internally Generated Decadal Climate Variability Associated with the Interdecadal Pacific Oscillation." Journal of Climate 26, no. 18 (September 9, 2013): 7298–310. http://dx.doi.org/10.1175/jcli-d-12-00548.1.

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Анотація:
Abstract Globally averaged surface air temperatures in some decades show rapid increases (accelerated warming decades), and in other decades there is no warming trend (hiatus decades). A previous study showed that the net energy imbalance at the top of the atmosphere of about 1 W m−2 is associated with greater increases of deep ocean heat content below 750 m during the hiatus decades, while there is little globally averaged surface temperature increase or warming in the upper ocean layers. Here the authors examine processes involved with accelerated warming decades and address the relative roles of external forcing from increasing greenhouse gases and internally generated decadal climate variability associated with interdecadal Pacific oscillation (IPO). Model results from the Community Climate System Model, version 4 (CCSM4), show that accelerated warming decades are characterized by rapid warming of globally averaged surface air temperature, greater increases of heat content in the upper ocean layers, and less heat content increase in the deep ocean, opposite to the hiatus decades. In addition to contributions from processes potentially linked to Antarctic Bottom Water (AABW) formation and the Atlantic meridional overturning circulation (AMOC), the positive phase of the IPO, adding to the response to external forcing, is usually associated with accelerated warming decades. Conversely, hiatus decades typically occur with the negative phase of the IPO, when warming from the external forcing is overwhelmed by internally generated cooling in the tropical Pacific. Internally generated hiatus periods of up to 15 years with zero global warming trend are present in the future climate simulations. This suggests that there is a chance that the current observed hiatus could extend for several more years.
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39

Voarintsoa, Ny Riavo G., George A. Brook, Fuyuan Liang, Eugene Marais, Ben Hardt, Hai Cheng, R. Lawrence Edwards, and L. Bruce Railsback. "Stalagmite multi-proxy evidence of wet and dry intervals in northeastern Namibia: Linkage to latitudinal shifts of the Inter-Tropical Convergence Zone and changing solar activity from AD 1400 to 1950." Holocene 27, no. 3 (July 28, 2016): 384–96. http://dx.doi.org/10.1177/0959683616660170.

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Анотація:
Multiple proxies using variation in δ18O, δ13C, mineralogy, and petrography in a newly generated high-resolution record of Stalagmite DP1 from Dante Cave indicate a linkage between changes in hydroclimate in northeastern Namibia and changes in solar activity and changes in global temperatures. The record suggests that during solar minima and globally cooler conditions (ca. 1660–1710 and ca. 1790–1830), wetter periods (reflecting longer summer seasons) in northeastern Namibia were linked to advances of the Inter-Tropical Convergence Zone (ITCZ) and the Inter-Ocean Convergence Zone (IOCZ) southwestward. A slight southward push of the Angola–Benguela Front (ABF) during such intervals could also be expected, bringing more rainfall inland. On the other hand, drier and warmer periods in northeastern Namibia, inferred from the increasing δ18O trend in Stalagmite DP1 after AD 1715, coincide with globally warmer conditions, and thus a northeastward migration of the ITCZ, specifically with more warming of the Northern Hemisphere (NH). This finding agrees with reducing precipitation observed in the summer rainfall zone of southern Africa since ca. 1900. Therefore, predictions of warming in high-latitude regions of the NH in the next century should suggest that the presently semi-arid climate of northern Namibia may become even drier.
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40

Kline, David I., Alex Dehgan, Paul Bunje, Shah Selbe, Ved Chirayath, Oscar Pizarro, Matthieu Leray, et al. "The Coral Reef Sentinels Program: A Mars Shot for Blue Planetary Health." Marine Technology Society Journal 55, no. 3 (May 1, 2021): 118–19. http://dx.doi.org/10.4031/mtsj.55.3.51.

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Анотація:
Abstract Up to 90% of global coral reefs are predicted to be severely degraded by 2050 under “business-as-usual” scenarios. To meet the scale and scope of this challenge, we propose designing and demonstrating a multi-modal system that can incorporate data from remote sensing (satellites, aircraft, and aerial drones), acoustics, genetics, sensor arrays, and low-cost imaging systems. The latter will be collected by low-cost smart sensing and autonomous underwater vehicles (AUVs) guided by adaptive sampling modeling software and rapidly analyzed using automated machine learning systems. Development and deployment will be linked to extensive and diversity-enhancing training programs. The Coral Sentinel System will be globally deployed to enable rapid-response adaptive management and to build public engagement in conservation interventions to save coral reefs.Phase 1 (Year 1) will involve testing assumptions, coalition building, fundraising, and initial system development. Phase 2 (Years 2‐4) will focus on engineering and development with a pilot deployment in the Caribbean. Phase 3 (Years 5‐6) will involve system expansion and iteration along the Tropical Eastern Pacific corridor. Phase 4 (Years 7‐10) will involve global deployment to over 50 reef sites. This will lead during the following decade (Phase 5) to provisioning of low-cost Sentinel systems to coastal communities globally.
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41

Navid, Muhammad Tariq, Raheela Akthar, and Muhammad Zeeshan Bhatti. "Perspectives of emerging zoonoses – challenges and opportunities." Life and Science 1, no. 4 (October 16, 2020): 5. http://dx.doi.org/10.37185/lns.1.1.70.

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Анотація:
Zoonoses are the infectious diseases that are linked with human and animals. During the last few decades, human-animal linkages and close associations have been increased the zoonotic diseases threats upto several times. The increasing demand and love for animal based edible proteins have resulted higher rate of human-animal interaction. Greater the interaction rate, higher the zoonotic disease threat. Moreover, the human, animal and environmental factors have increased the threat of vector-borne and food–borne illnesses globally. In the present study, we have focused on vector-borne and food-borne diseases that are transmissible between human and animal species. We have highlighted a few opportunities through which we can reduce the chances of emerging zoonotic disease illnesses in developing countries such as Pakistan.
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42

Fajgelbaum, Pablo D., and Edouard Schaal. "Optimal Transport Networks in Spatial Equilibrium." Econometrica 88, no. 4 (2020): 1411–52. http://dx.doi.org/10.3982/ecta15213.

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Анотація:
We study optimal transport networks in spatial equilibrium. We develop a framework consisting of a neoclassical trade model with labor mobility in which locations are arranged on a graph. Goods must be shipped through linked locations, and transport costs depend on congestion and on the infrastructure in each link, giving rise to an optimal transport problem in general equilibrium. The optimal transport network is the solution to a social planner's problem of building infrastructure in each link. We provide conditions such that this problem is globally convex, guaranteeing its numerical tractability. We also study cases with increasing returns to transport technologies in which global convexity fails. We apply the framework to assess optimal investments and inefficiencies in the road networks of European countries.
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43

Bogdanet, Delia, Paula O’Shea, Claire Lyons, Amir Shafat, and Fidelma Dunne. "The Oral Glucose Tolerance Test—Is It Time for a Change?—A Literature Review with an Emphasis on Pregnancy." Journal of Clinical Medicine 9, no. 11 (October 27, 2020): 3451. http://dx.doi.org/10.3390/jcm9113451.

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Анотація:
Globally, gestational diabetes (GDM) is increasing at an alarming rate. This increase is linked to the rise in obesity rates among women of reproductive age. GDM poses a major global health problem due to the related micro- and macro-vascular complications of subsequent Type 2 diabetes and the impact on the future health of generations through the long-term impact of GDM on both mothers and their infants. Therefore, correctly identifying subjects as having GDM is of utmost importance. The oral glucose tolerance test (OGTT) has been the mainstay for diagnosing gestational diabetes for decades. However, this test is deeply flawed. In this review, we explore a history of the OGTT, its reproducibility and the many factors that can impact its results with an emphasis on pregnancy.
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44

Dowson, Chris. "Continuing Education Reform in Hong Kong." education policy analysis archives 11 (February 6, 2003): 5. http://dx.doi.org/10.14507/epaa.v11n5.2003.

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Анотація:
Following initiations in educational reform that began in the 1990s, Hong Kong continues to experience considerable pressure for educational reform. On the surface many of these initiatives parallel reform policies/movements in Asia and indeed, globally. The success of any reform is dependent on how it is contextualised prior to and at implementation. In this article, an exploration is made into how reforms in four particular sareas, namely: professional development of principals, higher education, English language standards, and inclusion of students with learning difficulties have been conceived, contextualised and managed in Hong Kong, as it moves gradually toward increased adoption of education reforms. These areas are linked in that each describes and critiques contextualization with reference to areas such as accountability, co-operation and professional control.
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45

Stancu, Alina, and Nicolae Suvorov. "Step by step conversion to organic agriculture." Western Balkan Journal of Agricultural Economics and Rural Development 3, no. 1 (2021): 11–21. http://dx.doi.org/10.5937/wbjae2101011s.

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Анотація:
The controversial issue of genetically modified organisms and environmental pollution, which often leads to global warming, brings us face to face with the need to change the way agriculture leaves its mark on the ecological balance. If common efforts were focused on designing a multidisciplinary agricultural system that produces quantitatively and nutritionally sufficient food while protecting biodiversity and non-renewable resources, the problems that the agricultural sector generates would be greatly reduced. Paper provides introductory information linked to conversion from conventional to organic system of agriculture from the aspect of sustainable development. Familiarity with new eco-friendly practices is essential for exploiting the opportunities for the agricultural sector. In this context, the paper analyses the general consequences observed by some of globally recognized institutions involved in agriculture.
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46

Brune, W. H., P. J. McFarland, E. Bruning, S. Waugh, D. MacGorman, D. O. Miller, J. M. Jenkins, X. Ren, J. Mao, and J. Peischl. "Extreme oxidant amounts produced by lightning in storm clouds." Science 372, no. 6543 (April 29, 2021): 711–15. http://dx.doi.org/10.1126/science.abg0492.

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Анотація:
Lightning increases the atmosphere’s ability to cleanse itself by producing nitric oxide (NO), leading to atmospheric chemistry that forms ozone (O3) and the atmosphere’s primary oxidant, the hydroxyl radical (OH). Our analysis of a 2012 airborne study of deep convection and chemistry demonstrates that lightning also directly generates the oxidants OH and the hydroperoxyl radical (HO2). Extreme amounts of OH and HO2 were discovered and linked to visible flashes occurring in front of the aircraft and to subvisible discharges in electrified anvil regions. This enhanced OH and HO2 is orders of magnitude greater than any previous atmospheric observation. Lightning-generated OH in all storms happening at the same time globally can be responsible for a highly uncertain, but substantial, 2 to 16% of global atmospheric OH oxidation.
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47

Çavdar, Gamze, Theresa Papich, and Elizabeth P. Ryan. "Microbiome, Breastfeeding and Public Health Policy in the United States: The Case for Dietary Fiber." Nutrition and Metabolic Insights 12 (January 2019): 117863881986959. http://dx.doi.org/10.1177/1178638819869597.

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Анотація:
An emerging body of literature has highlighted the significance of breastmilk oligosaccharides and dietary fibers in complementary weaning foods for the development of the infant’s microbiome that has both short- and long-term health implications. This review highlights the newborns’ consumption of fiber and oligosaccharides as directly linked to the mother’s diet, and that current dietary recommendations for pregnant mothers in the United States and globally fall short in both addressing the importance of dietary fiber intake for enhancing mother’s health and establishing the developing infant microbiome. Although limited in data, there is suggestion for maternal dietary interventions to include healthy fibers as an effective means of promoting infant health via modification of breast milk composition. This paper argues that there is an urgent need for a two-fold national policy that addresses the significance of fiber in breastfeeding mothers’ diets and modifies the dietary recommendations accordingly, and provides a paid parental leave, which would enable mothers to not only breastfeed for at least six months, but to also effectively follow the dietary recommendations needed to support breast milk quality that is linked to their infants’ health.
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48

Shin, Hye Ran, SuJin Song, Jin Ah Cho, and Sun Yung Ly. "Atherogenic Index of Plasma and Its Association with Risk Factors of Coronary Artery Disease and Nutrient Intake in Korean Adult Men: The 2013–2014 KNHANES." Nutrients 14, no. 5 (March 3, 2022): 1071. http://dx.doi.org/10.3390/nu14051071.

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Анотація:
Coronary artery disease (CAD) has been linked to one of the highest death rates globally. The atherogenic index of plasma (AIP) may be an important predictor of atherosclerosis and cardiovascular disease, superior to the standard atherosclerotic lipid profile. This study investigated the relationship between AIP and obesity indices, blood glucose, lipid profile, and nutrient intake status in Korean adult men. The study included 1292 males aged ≥19 years old who participated in the Korea National Health and Nutrition Examination Survey, 2013–2014. Participants were divided into four groups according to AIP quartiles, calculated as log (triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C)). Body mass index, waist circumference, fasting blood glucose, hemoglobin A1c, total cholesterol, TG, and low-density lipoprotein cholesterol levels increased as AIP levels increased, whereas HDL-C level declined. As the level of AIP increased, intake of saturated fatty acid, calcium, phosphorus, riboflavin, milk, and dairy product decreased significantly, and the contribution rate of milk and dairy products to fat intake decreased. AIP was linked to obesity indices, blood glucose, and blood lipid profile in Korean men, suggesting that it could predict CAD.
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49

Polakova, Gabriela. "Evaluation of Globally Operating Salesforce Staff by Multiple Attribute Decision Making Methods." SHS Web of Conferences 74 (2020): 06025. http://dx.doi.org/10.1051/shsconf/20207406025.

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Анотація:
Business managers, globally sales executives operating worldwide, representing brands and good reputation of international companies are a special group of staff needing especially flexible working conditions to do their job all over the world. The evaluation and rewarding of their performance is globally linked to achieving business targets. How evaluate results of all involved staff working on different international markets as one set of so many variants and criteria with ensuring transparency, objectivity and fairness? The solution is found in multiple attribute decision methods (MADM). The aim of the paper is to evaluate a group of salesforce staff making international business world-wide by using MADM to identify and reward the best sales executives and at the same time manage to make them to feel be valued for their well-done work, efforts and achievements. Two methods of multiple attribute decision making were used for this evaluation – the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) and the Weighted Sum Approach (WSA). The results of both methods were compared and the more suitable method for this universal application practicable world-wide in terms of the processing complexity and the user friendliness was chosen and recommended. The bonus scheme is based on a healthy competition for sales executives, on a motivation to grow up and gain better results to get additional special bonus beyond the standard rewards for meeting performance targets. Part of this papers is the proposal of flexible bonuses for reached positions in the ranking of evaluated employees.
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50

Tonhajzerova, Ingrid, Nikola Sekaninova, Lucia Bona Olexova, and Zuzana Visnovcova. "Novel Insight into Neuroimmune Regulatory Mechanisms and Biomarkers Linking Major Depression and Vascular Diseases: The Dilemma Continues." International Journal of Molecular Sciences 21, no. 7 (March 27, 2020): 2317. http://dx.doi.org/10.3390/ijms21072317.

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Анотація:
Major depressive disorder (MDD) represents a serious health problem estimated to affect 350 million people globally. Importantly, MDD has repeatedly emerged as an etiological or prognostic factor in cardiovascular disease (CVD) development, including vascular pathology. Several linking pathomechanisms between MDD and CVD involve abnormal autonomic regulation, inflammation, and endothelial dysfunction as an early preclinical stage of atherosclerosis. However, the cause of accelerated atherosclerosis in MDD patients remains unclear. Recently, the causal relationships between MDD and mediator (e.g., inflammation and/or endothelial dysfunction), as well as the causal pathways from the mediator to atherosclerosis, were discussed. Specifically, MDD is accompanied by immune dysregulation, resulting in increased production of proinflammatory cytokines (e.g., interleukin (IL)-6 and tumor necrosis factor (TNF)-α), which could lead to depression-linked abnormalities in brain function. Further, MDD has an adverse effect on endothelial function; for example, circulating markers of endothelial dysfunction (e.g., soluble adhesion molecules, von Willebrand factor) have been linked with depression. Additionally, MDD-linked autonomic dysregulation, which is characterized by disrupted sympathovagal balance associated with excessive circulating catecholamines, can contribute to CVD. Taken together, activated inflammatory response, endothelial dysfunction, and autonomic dysregulation could affect gradual atherosclerosis progression, resulting in a higher risk of developing CVD in MDD. This review focused on the pathomechanisms linking MDD and CVD with respect to neuroimmune regulation, and the description of promising biomarkers, which is important for the early diagnosis and personalized prevention of CVD in major depression.
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