Дисертації з теми "Gestational Age Infants"
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Kranen-Mastenbroek, Vivianne Henriëtte Johanna Maria van. "Spontaneous motor behaviour in full-term small for gestational age and appropriate for gestational age newborn infants." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=5853.
Повний текст джерелаHorta, Bernardo Lessa. "Determinants of catch-up growth in small-for-gestational age infants." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38067.
Повний текст джерелаDesign. Cohort study, with follow-up visits at 1, 3, 6 and 12 months.
Setting. Pelotas, a southern Brazilian city.
Population. SGA infants who were born in 1993 and whose families lived in the urban area of Pelotas.
Main outcomes. Weight and length gain from birth to 6 months and from 6 to 12 months.
Results. Two hundred twenty term SGA infants were targeted for follow-up, which was achieved for 205 (93.2%) infants at 12 months. At 6 months, the proportion of infants with weight-for-age and length-for-age z-scores <-1.28 SDS was 18.9% and 37.8%, respectively. At 12 months, the proportion of children with a weight-for-age z-score <-1.28 SDS increased to 35.2%, whereas for length-for-age this proportion remained about the same as it had been at 6 months. Severity of intrauterine growth retardation, body proportionality at birth, maternal remunerated work after delivery, maternal age, parity, maternal prepregnancy body mass index and maternal smoking during pregnancy had no significant effect on postnatal growth in the first year of life. Those infants who were weaned by 1 month had faster weight and length gain by 6 months. Socioeconomic status (SES) modified the effect of breast feeding duration on weight and length gain in the first 6 months of life. Among high-SES families, those children who were weaned by 1 month gained 578 g more than those still breast feeding at 6 months. Among low-SES families, however, those children who were weaned by 1 month gained 349 g less than those still breast feeding at 6 months. Those children who were weaned by 6 months had faster weight gain from 6 to 12 months, and this association was not modified by SES, while low SES was associated with slower weight and length gain in the same period. Children of short (<150 cm) mothers gained 1.31 cm less (95% confidence interval -2.52 to -0.1) by 6 months than those of mothers >160 cm. Children who were hospitalized showed a nonsignificantly slower length gain throughout the first year of life.
Conclusion. SGA infants experienced catch-up growth for weight and length but remained shorter and lighter than those in the NCHS reference population at both 6 and 12 months of age. Socioeconomic status and infant feeding were the main determinants of catch-up growth.
Davenport, Sarah E. "Potential Causes of Extrauterine Growth Failure in Premature Infants Born Appropriate for Gestational Age." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1137.
Повний текст джерелаRead, Anne Winifred. "An epidemiological study of small-for-gestational age infants: A case-control study of mothers who repeated small-for-gestational age births and multiparous mothers who had only one such birth." Thesis, Read, Anne Winifred (1988) An epidemiological study of small-for-gestational age infants: A case-control study of mothers who repeated small-for-gestational age births and multiparous mothers who had only one such birth. PhD thesis, Murdoch University, 1988. https://researchrepository.murdoch.edu.au/id/eprint/52315/.
Повний текст джерелаDube, Frederick. "The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/10377.
Повний текст джерелаBacillus Calmette?Gu?rin (BCG), the only currently licensed tuberculosis (TB) vaccine, provides variable efficacy. Despite the use of BCG, TB remains a global health problem. BCG is administered at birth; however, more than 15% of infants are born preterm [PT (<37 weeks gestation)], or have low birth weights [LBW (<2,500g)], with >90% of these born in developing countries, where the majority of TB cases are found. It is not known how birth weight at the time of vaccination may affect the BCG-induced immune response and subsequent protection against TB. We hypothesised that BCG-vaccinated PT and LBW infants would have a qualitatively and quantitatevely less optimal immune response, compared to term or normal birth weight (NBW) infants.
Maleki-Yazdi, Keon. "The genetic determinants of small-for-gestational-age infants in thrombophilia and folate metabolism pathways investigated through meta-analysis." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121509.
Повний текст джерелаContexte: La variation d'un seul élément du code moléculaire dite polymorphisme du nucléotide simple ou SNP peut contribuer à l'incidence de maladies dites complexes. Certains SNPs sur des gènes de thrombophilie et du métabolisme de l'acide folique dans le génome de la mère ont été associés avec un risque accru pour leurs bébés de naître petits pour leur âge gestationnel (PAG). Cependant, ces résultats ne sont pas uniformes. Méthodes: Cette thèse recense les études portant sur les SNPs dans les voies métaboliques de thrombophilie et du cycle du folate et l'issue de grossesse PAG (définie par un poids à la naissance inférieur au 10e percentile pour le sexe et l'âge gestationnel selon les normes nationales). Nous avons effectué une série de méta-analyses sur les SNPs nommés prothrombine G20210A et facteur V Leiden G1691A dans la voie de thrombophilie, ainsi que sur deux SNPs du gène méthylènetétrahydrofolate réductase (MTHFR) soient C677T et A1298C impliqués dans le métabolisme du folate. Résultats: Notre méta-analyse sur les voies de la thrombophilie a montré un risque accru de naissances PAG quand les mères portent le SNP G20210A (odds ratio=1,39 [intervalle de confiance à 95%: 1,10 à 1,76]. Des résultats non significatifs ont été trouvés lorsque la mère porte le facteur V Leiden, ainsi que lorsque le nouveau-né est porteur des SNP G20210A et facteur V Leiden. En ce qui concerne la voie du métabolisme du folate, les seuls résultats qui ont atteint la signification statistique étaient les suivants : lorsque les mères portaient la variation en une copie de C677T (odds ratio=1,22 [intervalle de confiance à 95%: 1,05 à 1,42]), étaient homozygotes (2 copies) pour C677T (odds ratio=1,18 [intervalle de confiance à 95%: 1,03 à 1,35]) ou homozygotes pour A1298C (odds ratio=0,70 [intervalle de confiance à 95%: 0,50 à 0,98]). Conclusion: À notre connaissance, cette étude est la première à décrire dans une méta-analyse des associations significatives entre un risque accru de naissances PAG et le fait que les mères portent une copie des SNPs prothrombine G20210A et MTHFR C677T ou deux copies de MTHFR C677T. Aussi, nous avons trouvé qu'il y avait une diminution du risque de PAG chez les femmes porteuses du SNP MTHFR A1298C.
Nagai, Shizuyo. "Gonadotropin Levels in Urine during Early Postnatal Period in Small-for-Gestational Age Preterm Male Infants with Fetal Growth Restriction." Kyoto University, 2017. http://hdl.handle.net/2433/226767.
Повний текст джерелаNyirati, Christina. "Profiles of risk for low birth weight, small for gestational age, and premature infants among Appalachian Ohio teenagers : a birth certificate study /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487844105973922.
Повний текст джерелаLum, Sook-Yuen. "Influence of low birthweight for gestational age on airway function in early infancy." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398863.
Повний текст джерелаAhlsson, Fredrik. "Being Born Large for Gestational Age : Metabolic and Epidemiological Studies." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9135.
Повний текст джерелаSt-Arnaud-Trempe, Emmanuelle. "Effect of low alcohol consumption during pregnancy on the risk of small-for-gestational-age (SGA) birth." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116079.
Повний текст джерелаGelaye, Bizu, Amber Domingue, Fernanda Rebelo, Lauren E. Friedman, Chunfang Qiu, Sixto E. Sanchez, Gloria Larrabure-Torrealva, and Michelle A. Williams. "Association of antepartum suicidal ideation during the third trimester with infant birth weight and gestational age at delivery." Routledge, 2019. http://hdl.handle.net/10757/625044.
Повний текст джерелаAntepartum suicidal behaviors are a leading cause of maternal injury and death. Previous research has not investigated associations between antepartum suicidal ideation and perinatal complications. Our study objective was to evaluate the relationship of antepartum suicidal ideation with low infant birthweight, small for gestational age, and preterm birth. A cohort study was conducted among 1,108 women receiving prenatal care in Peru. Suicidal ideation was measured using the Patient Health Questionnaire-9 during pregnancy. Birth outcomes were extracted from medical records. Linear regressions and multivariable logistic regressions were used to estimate were used to investigate associations between suicidal ideation and pregnancy outcomes. The prevalence of suicidal ideation was 8.7%, preterm delivery was 5.7%, low birthweight was 4.4%, and small for gestational age was 3.4%. In an adjusted model, infant birthweight was 94.2 grams lower for mothers with antepartum suicidal ideation (95% CI: −183.0, −5.5, p = 0.037) compared with those without suicidal ideation. After adjusting for confounders including depression, participants with suicidal ideation had a nearly four-fold increased odds of delivering a small for gestational age infant (OR: 3.73; 95% CI: 1.59–8.74). These findings suggest suicidal ideation during pregnancy is associated with adverse perinatal outcomes, especially low infant birthweight.
Revisión por pares
Gelaye, Bizu, Amber Domingue, Fernanda Rebelo, Lauren E. Friedman, Chunfang Qiu, Sixto E. Sanchez, Gloria Larrabure-Torrealva, and Michelle A. Williams. "Association of antepartum suicidal ideation during the third trimester with infant birth weight and gestational age at delivery." Routledge, 2018. http://hdl.handle.net/10757/624715.
Повний текст джерелаAntepartum suicidal behaviors are a leading cause of maternal injury and death. Previous research has not investigated associations between antepartum suicidal ideation and perinatal complications. Our study objective was to evaluate the relationship of antepartum suicidal ideation with low infant birthweight, small for gestational age, and preterm birth. A cohort study was conducted among 1,108 women receiving prenatal care in Peru. Suicidal ideation was measured using the Patient Health Questionnaire-9 during pregnancy. Birth outcomes were extracted from medical records. Linear regressions and multivariable logistic regressions were used to estimate were used to investigate associations between suicidal ideation and pregnancy outcomes. The prevalence of suicidal ideation was 8.7%, preterm delivery was 5.7%, low birthweight was 4.4%, and small for gestational age was 3.4%. In an adjusted model, infant birthweight was 94.2 grams lower for mothers with antepartum suicidal ideation (95% CI: −183.0, −5.5, p = 0.037) compared with those without suicidal ideation. After adjusting for confounders including depression, participants with suicidal ideation had a nearly four-fold increased odds of delivering a small for gestational age infant (OR: 3.73; 95% CI: 1.59–8.74). These findings suggest suicidal ideation during pregnancy is associated with adverse perinatal outcomes, especially low infant birthweight.
Revisión por pares
Francis, Kim. "Development of a New Pain Assessment Instrument: Pain Assessment and Care for the Extremely Low Gestational Age Infant Focused Instrument (PACEFI)." Thesis, Boston College, 2012. http://hdl.handle.net/2345/3898.
Повний текст джерелаPain in extremely low gestational age (ELGA) infants remains under-assessed and poorly managed despite the fact that pain may have profound consequences with regard to infants' neuro-development (Als, 1982). Pain prevention is a critical goal of pain assessment, yet barriers exist. Most critical is the lack of valid, reliable, and clinically useful pain tools. This observational descriptive study focused on the development of a gestational age appropriate instrument for 24-29 6/7 week infants and evaluation of the new instrument, Pain Assessment and Care for the Extremely Low Gestational Age Infant Focused Instrument (PACEFI). Additionally, differences in behavioral cues and physiologic indicators were evaluated for ELGA infants and very low gestational age (VLGA) infants for non-invasive and invasive procedures. Nurse raters used the PACEFI to rate these infants during both procedures at baseline, during, and recovery to assess variation in expected pain. The PACEFI demonstrated a high internal consistency (.879) and appeared to be contributing to the measurement of pain. A RANOVA found a significant difference in rating scores ( p < .001) for both procedures. Baseline and recovery scores were lower than during scores. ELGA infants demonstrated a dampened response (p < .023) as compared to the VLGA infants during the invasive procedure. Alternatively, ELGA infants demonstrated a more vigorous response for non-invasive procedure and dropped below baseline scores at recovery. The whole care experience during the non-invasive procedure may have led to sensitization for the VLGA infant and overwhelming energy expenditure for the ELGA infant. Furthermore, physiologic indicators and behavioral cues were inconsistent arguing for independent assessment of these parameters. Knowledge gained from this study: 1) provides information regarding gestational age differences in pain behaviors; and (2) clarifies if the measurement of these behaviors addresses the immediate need for pain assessment for this vulnerable population
Thesis (PhD) — Boston College, 2012
Submitted to: Boston College. Connell School of Nursing
Discipline: Nursing
Frunza, A. V. "The role of urinary β2-microglobulin in predicting tubular damage in premature infants of different gestational ages". Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19798.
Повний текст джерелаGriffin, Melanie Joanne. "Use of third trimester serum biomarkers and ultrasound paameters to predict the small for gestational age infant at delivery." Thesis, King's College London (University of London), 2015. https://kclpure.kcl.ac.uk/portal/en/theses/use-of-third-trimester-serum-biomarkers-and-ultrasound-paameters-to-predict-the-small-for-gestational-age-infant-at-delivery(1d747923-4eb0-4060-a31e-4d7a28dfa61f).html.
Повний текст джерелаKistner, Anna. "Born too small or too early : effects on blood pressure, renal function and retinal vascularization in adulthood : experimental and clinical studies /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-154-7/.
Повний текст джерелаEdner, Ann. "Apnea, small for date and autonomic imbalance - risk factors in relation to SIDS /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-503-4/.
Повний текст джерелаGómez, Maria Del Pilar Vélez. "Estudo intergeracional do peso ao nascer e da idade gestacional na coorte de nascimentos de 1982, Pelotas, Brasil." Universidade Federal de Pelotas, 2006. http://repositorio.ufpel.edu.br/handle/ri/1967.
Повний текст джерела794 women from the 1982 Pelotas Birth Cohort Study and their first singleton live-born birth were selected to explore the association between maternal and offspring birthweight and gestational age, as well as to discriminate between confounders and mediating factors of these associations. Exposures were maternal birthweight and gestational age, low birthweight (LBW; <2500g), preterm birth (<37 weeks) and small for gestational age status (SGA; <10 th percentile of Williams), to the respective outcomes in offspring. Information was gathered on potential confounding or mediating factors according to a hierarchical framework approach. A strong correlation coefficient was found between maternal and infant birthweight (r=0.18, p<0.001). An increase of 100g in mothers birthweight predicted a gain of 16g in their infants birthweight (95% CI 8.0, 24.0g; p<0.001). Maternal LBW was independently associated to offspring LBW, preterm and SGA status. SGA mothers had an increased risk of delivering a preterm newborn. Causal chain linking maternal LBW and SGA of the newborn was mediated by maternal pre-gestational weight (a proxy of malnutrition), a condition closely related to poverty. Thus, malnourished women are likely to give birth to LBW babies, perpetuating poverty in the subsequent generation. Addressing malnutrition helps break this vicious cycle and stop the intergenerational transmission of LBW, hence decreasing poverty and malnutrition in developing countries.
794 women from the 1982 Pelotas Birth Cohort Study and their first singleton live-born birth were selected to explore the association between maternal and offspring birthweight and gestational age, as well as to discriminate between confounders and mediating factors of these associations. Exposures were maternal birthweight and gestational age, low birthweight (LBW; <2500g), preterm birth (<37 weeks) and small for gestational age status (SGA; <10 th percentile of Williams), to the respective outcomes in offspring. Information was gathered on potential confounding or mediating factors according to a hierarchical framework approach. A strong correlation coefficient was found between maternal and infant birthweight (r=0.18, p<0.001). An increase of 100g in mothers birthweight predicted a gain of 16g in their infants birthweight (95% CI 8.0, 24.0g; p <0.001). Maternal LBW was independently associated to offspring LBW, preterm and SGA status. SGA mothers had an increased risk of delivering a preterm newborn. Causal chain linking maternal LBW and SGA of the newborn was mediated by maternal pre-gestational weight (a proxy of malnutrition), a condition closely related to poverty. Thus, malnourished women are likely to give birth to LBW babies, perpetuating poverty in the subsequent generation. Addressing malnutrition helps break this vicious cycle and stop the intergenerational transmission of LBW, hence decreasing poverty and malnutrition in developing countries.
Neuwald, Marla Finkler. "Peso ao nascer e cuidado parental percebido pela mãe : interações pré e pós-natais sobre o comportamento infantil aos 18 meses de vida." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/67519.
Повний текст джерелаIntroduction: Evidence suggests an association between being born small for gestational age (SGA) and the increased risk for behavioral problems. Besides that, individuals who report have received lower quality of maternal care show increased prevalence of depression and anxiety, as well as in general are poorer caregivers of their offspring. Therefore, an interaction between the birth weight status and the quality of maternal care perceived by the mother could affect the cognitive functioning later in life. This study aimed to evaluate the interaction between being born SGA and the parental bonding perceived by the mother on the children’s behavior at 18 months of age. Methodology: a nested cross-sectional evaluation of a prospective Canadian birth cohort (MAVAN, Maternal Adversity, Vulnerability and Neurodevelopment), developed between the years of 2003 and 2010. Data from 305 children evaluated at 18 months of age and that had all three questionnaires completed (Parental Bonding Intrument - PBI, Early Chidhood Behavior Questionnaire - ECBQ and Infant-Toddler Social and Emotional Assessment – ITSEA) were used. Multivariate ANOVA accounting for parental interactions was used for the analysis. Results: Children born SGA from mothers reporting low maternal care had lower scores in the attentional set shifting trait (ECBQ, p=0.002) and attention construct (ITSEA, p=0.05) at 18 months of age. We also found isolated effects of SGA decreasing cuddliness (p=0.011) and high maternal care per se increased ECBQ low intensity pleasure (p=0.016) and attentional shifting (p=0.004). Conclusion: The findings reinforce the importance of a systemic developmental vision that integrates early environmental aspects and parental care in the first years of life. Besides, the effects on attention found already at 18 months have clinical relevance as it may serve as a warning sign for this population.
Ekholm, Selling Katarina. "Birth-characteristics, hospitalisations, and childbearing : Epidemiological studies based on Swedish register data." Doctoral thesis, Linköping : Faculty of Health Sciences, Linköping University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-9660.
Повний текст джерелаTaylor, Marian. "Infant Mortality Among African American Women Compared to European American Women in New York City." ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3841.
Повний текст джерелаBergvall, Niklas. "Fetal programming and subsequent risks in adulthood: are the associations confounded by genetic and/or environmental factors? /." Stockholm : Department of Medical Epidemiology and Biostatistics, Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-271-2/.
Повний текст джерелаBrock, Romy Schmidt. "Valores de referência do índice de massa corpórea para recém-nascidos de acordo com a idade gestacional." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-06022007-160826/.
Повний текст джерелаINTRODUCTION: The nutritional assessment of the newborn has been a challenging essay and any deviation from the normal is associated with an increased risk of morbidity and mortality. Anthropometric parameters have been the most important method to evaluate newborn nutrition. They are important in reflecting intrauterine growth and in defining a baseline for the infants\' follow-up. A single standard anthropometric factor, as the measure of simple weight, cannot assess the nutritional status of the newborn properly. The use of a combination of two anthropometric factors has been more appropriate to assess body composition and proportions. The Body Mass Index (BMI) has become the measure of choice for the determination of nutritional status during pediatric years, as it assesses the relationship between weight and length, however there is a lack of reference values for the neonatal period. OBJECTIVES: This report presents references for body mass index of the newborn at different gestational ages for both sexes, and to construct a normal smoothed percentile curve. METHODS: Retrospective study including all admitted infants, born between January 1993 and January 2004, at the Newborn Nursery of Clinics Hospital, School of Medicine, University of São Paulo. The appropriate for gestational age newborns, following the Alexander et al curve (1996) were included. The excluded cases were represented by newborns with impaired fetal growth or abnormalities such as hydrops fetalis, congenital malformations or multiple births. The overall sample size was determined by the need to obtain sufficient data for valid calculation of percentile values from 29 to 42 weeks, totalling 2406 infants. The BMI was calculated based on the formula: [weight (kg)/ length (m)2 ], and selected percentiles (3, 5, 10, 25, 50, 75, 90, 95, 97) were determined for all target gestational ages. For the construction of a normal smoothed percentile curve, a statistical procedure based on the mathematical model of \"sinusoidal fit\" was applied to establish a curve that estimates the biological growth parameters. RESULTS: The BMI for gestational age and gender increased sharply from 29 to 40 weeks in all percentiles, followed by a slight increase up to 42 weeks. The values of the 50 th percentile for boys were 8,53 kg/m 2 in the 29 th week and 14,02 kg/m 2 in the 42 nd week. The girls values of the 50 th percentile were 8,36 kg/m 2 and 14,04 kg/m 2 in the 29 th and 42 nd week, respectively. There was no statistical difference between the BMI values for both sexes in the 9 percentiles evaluated. CONCLUSION: The results present a direct correlation between gestational age and BMI for both genders in the 9 studied percentiles. The BMI growth charts are useful to characterize the newborn BMI in different gestational ages, and can provide a useful reference to assess intra-uterine proportional growth.
Alburquerque, Duglio Miguel Adrian, Mallqui Orion Pizango, and Mariaca José Eduardo Tejeda. "Ganancia de peso gestacional y su asociación con el pequeño para la edad gestacional: cohorte retrospectiva en un hospital 2000-2010." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2015. http://hdl.handle.net/10757/621620.
Повний текст джерелаObjective: to identify the main risk factors for term infants small for gestational age (SGA). Materials and methods: we conducted a retrospective cohort study using the database of Hospital María Auxiliadora, Lima, Peru, with information of all pregnant women during the period 2000-2010. We analyzed maternal age, parity, educational level, marital status, pre-pregnancy body mass index, number of prenatal visits (PNV), the presence of diseases such as preeclampsia, eclampsia, urinary tract infection and gestational diabetes as risk factors for SGA. The weight for gestational age was calculated on Peruvian percentiles. Crude relative risks (RR) and adjusted relative risk (aRR) with their respective confidence intervals at 95% for each variable was calculated using log binomial generalized linear models. Results: A total of 64 670 pregnant were included. The incidence of SGA was 7.2%. Preeclampsia (aRR 2.0, 95% CI: 1.86 to 2.15), eclampsia (aRR 3.22, 95% CI: 2.38 to 4.35), low maternal weight (aRR 1.38; 95% CI: 1.23 to 1.54), nulliparity (aRR 1.32; 95% CI: 1.23 to 1.42) and age ≥35 years (aRR 1.16, 95% CI: 1.04 to 1.29) were associated with an increased risk for newborn SGA. Also, a number of 0-2 PNV (aRR 1.43, 95% CI: 1.32 to 1.55), and 3-5 PNV (aRR 1.22; 95% CI: 1.14 to 1.32) were also found associated with an increased risk of newborn SGA, compared with 6-8 PNV. A number of ≥9 PNV (aRR 0.74; 95% CI: 0.69 to 0.80) was a protector factor. Conclusions: it is necessary to identify pregnant women with risk factors such as those found in this study, in order to reduce SGA. Particular emphasis on modifiable factors, such as the frequency of antenatal care visits, must be taken.
Torchin, Héloïse. "Déterminants précoces de la dysplasie broncho-pulmonaire chez les grands prématurés Placental complications and bronchopulmonary dysplasia: EPIPAGE-2 cohort study Histologic chorioamnionitis and bronchopulmonary dysplasia in preterm infants: the epidemiologic study on low gestational ages 2 cohort." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB213.
Повний текст джерелаBronchopulmonary dysplasia (BPD), due to disrupted development of the immature lungs, remains a common respiratory morbidity of very preterm birth. Our aim was to study antenatal and postnatal factors possibly associated with BPD at 36 weeks postmenstrual age, about which epidemiological results have been inconsistent. Data from the EPIPAGE-2 cohort study were used. We first studied the associations between placenta-mediated pregnancy complications and BPD. Pregnancies complicated by fetal growth restriction (FGR) were at higher odds of moderate to severe BPD, whereas hypertensive disorders of pregnancy without FGR were not. We then analyzed the impact of antenatal inflammation, defined using histological chorioamnionitis diagnosis. Among very preterm infants born after spontaneous preterm labor with intact membranes or after preterm premature rupture of the membranes, histological chorioamnionitis was not associated with moderate or severe BPD. Lastly, we found wide inter-center variability in care delivered to preterm infants from their very first days. However, we were not able to explain variations of BPD frequency between centers by these differences of care. Our results concerning the associations between two frequent pregnancy complications and BPD are in part contrary to current pathophysiological models. Understanding early BPD risk factors may help to better define patients for inclusion in clinical trials aiming to decrease BPD rates or severity and to improve clinicians and families knowledge about respiratory morbidity of preterm birth
Aragão, Luciana Felipe Férrer. "Preditores do ganho estatural em crianças nascidas pequenas para a idade gestacional tratadas com hormônio do crescimento humano recombinante." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-06012017-094255/.
Повний текст джерелаINTRODUCTION: Children born small for gestational age (SGA) are at increased risk for short stature in adulthood. Treatment benefits with rhGH (recombinant human growth hormone) is well established in children born SGA and inadequate growth catch up, therefore it is very importante to study height gain predictors in these individuals. OBJECTIVE: To evaluate therapeutic response and clinical variables associated with growth recovery in two years of rhGH treatment in a group of children born SGA. METHODS: Thirty-five children born SGA in use of rhGH for at least two years were selected and the following variables were evaluated: gender, gestational age, birth weight SDS, birth length SDS, birth weight index, chronological age at the beginning of treatment, target-height SDS, rhGH dose, chronological age and bone age relation, and delta IGF-I SDS. RESULTS: The mean height SDS had a significant increase of 0.55 SDS (p < 0.01) and 0.86 SDS (p < 0.01) in the first and second year of treatment with rhGH, respectively. The rhGH dose was identified as a height gain predictor after one year of treatment, while birth length SDS and gestational age were predictors of growth gain after two years of rhGH. CONCLUSION: A positive growth response to rhGH treatment was confirmed in children born SGA with no growth catch up in their first two years of life. Evaluation of individual characteristics at birth and in the beginning of rhGH treatment, as well as the identification growth predictors, are important for the decision and treatment optimization
Tejeda, Mariaca J. Eduardo, Mallqui Orion Pizango, Duglio Miguel Alburquerque, and Percy Mayta-Tristan. "Factores de riesgo para el neonato pequeño para la edad gestacional en un hospital de Lima." Instituto Nacional de Salud (INS), 2015. http://hdl.handle.net/10757/582632.
Повний текст джерелаObjetivos. Identificar factores de riesgo para neonatos a término pequeños para la edad gestacional. Materiales y métodos. Cohorte retrospectiva que utilizó datos del Sistema Informático Materno Perinatal del Hospital María Auxiliadora de Lima, del período 2000 a 2010. Se evaluó la edad materna, paridad, nivel educativo, estado civil, índice de masa corporal pregestacional, número de controles prenatales, presencia de patologías como preeclampsia, eclampsia, infección urinaria y diabetes gestacional como factores de riesgo en pequeños para edad gestacional. El peso para la edad gestacional fue calculado sobre la base de percentiles peruanos. Se calcularon los riesgos relativos crudos (RR) y ajustados (RRa) con sus intervalos de confianza al 95% usando modelos lineales generalizados log binomial. Resultados. Se incluyeron 64 670 gestantes. La incidencia de pequeños para la edad gestacional fue 7,2%. La preeclampsia (RRa 2,0; IC 95%: 1,86-2,15), eclampsia (RRa 3,22; IC 95%: 2,38-4,35), bajo peso materno (RRa 1,38; IC 95%: 1,23-1,54), nuliparidad (RRa 1,32; IC 95%: 1,23-1,42), edad ≥35 años (RRa 1,16; IC 95%: 1,04-1,29), tener controles prenatales de 0 a 2 (RRa 1,43; IC 95%: 1,32-1,55) y 3 a 5 (RRa 1,22; IC 95%: 1,14-1,32) fueron factores de riesgo para ser pequeños para la edad gestacional. Conclusiones. Es necesario identificar a las gestantes con factores de riesgo como los encontrados para disminuir la condición de pequeños para la edad gestacional. Se debe actuar poniendo énfasis en factores modificables, tales como la frecuencia de sus controles prenatales
Härkin, P. (Pia). "Closure of patent ductus arteriosus in very preterm infants:potential role of paracetamol and consequences of current treatments." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526220253.
Повний текст джерелаTiivistelmä Valtimotiehyt on sikiöaikana avoimena oleva suoni, joka yhdistää keuhkovaltimon laskevaan aorttaan ja ohjaa vähähappisen veren istukkaan. Yhdessä soikean aukon kanssa suoni takaa sikiön verenkierron normaalin toiminnan ennen keuhkojen avautumista. Mikäli valtimotiehyt jää syntymän jälkeen pitkittyneesti auki, muuttaa se keskosen verenkiertoa siten, että osa aortan verenkiertoa ohjautuu keuhkoverenkiertoon vaikeuttaen pienen keskosen toipumista. Nykyhoitoina käytetään joko lääkkeellistä (ibuprofeeni tai indometasiini) tai kirurgista sulkua. Lääkkeellinen hoito ei ole kovin tehokas kaikista epäkypsimmillä keskosilla ja hoitoihin liittyy vakaviakin sivuvaikutuksia. Väitöskirjassa tutkittiin parasetamolilääkityksen vaikutusta hyvin pienen keskosen avoimen valtimotiehyen sulkeutumiseen. Epidemiologisessa osiossa tutkittiin nykyhoitojen sivuvaikutuksia hyvin pienillä keskosilla. Osatyössä I todettiin, että avoimen valtimotiehyen hoidon tarve väheni merkittävästi sen jälkeen kun parasetamoli oli otettu käyttöön kivun hoidossa vastasyntyneiden teholla. Osatyö II oli satunnaistettu ja sokkoutettu hoitotutkimus, jossa todettiin alkuperäishavaintona, että parasetamolilla on biologinen vaikutus keskosen avoimeen valtimotiehyeen. Parasetamolia saaneilla keskosilla valtimotiehyt sulkeutui aikaisemmin kuin verrokeilla. Hoidolla ei todettu merkittäviä sivuvaikutuksia. Osatöissä III ja IV tutkittiin kaikkien vuosina 2005−2013 Suomessa syntyneiden hyvin pienten keskosten avoimen valtimotiehyen hoitoja. Lääkehoidolla (ibuprofeeni ja indometasiini) ja kirurgisella hoidolla todettiin olevan yhteys keskosen kroonisen keuhkotaudin (BPD) vaikeimpaan muotoon. Kirurgisella hoidolla oli yhteys keskosen vaikeaan suolitulehdukseen ja vaikeaan aivoverenvuotoon. Kuolleisuuden riskin ei kuitenkaan todettu lisääntyneen valtimotiehyen hoitoihin liittyen
Martinelli, Silvio. "Predição da restrição do crescimento fetal pela medida da altura uterina." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-23092014-160804/.
Повний текст джерелаThe aim of this study was to correlate uterine height measurements below the 5th and 10th percentiles using MARTINELLI et al. (2001) curve to fetal growth restriction (FGR) and to compare with the BELIZÁN et al. (1978) curve. During the period of July 2000 and February 2003, 238 pregnant women of high risk were submitted to uterine height measurements between the 20th and 42nd weeks of gestation. The whole group had well-known gestational age, confirmed by early ultrasound. The diagnosis of FGR was confirmed after birth according to RAMOS (1983). Among these women, 50 (21,0%) gave birth to light for gestational age infants. The same observer, using tape measure, performed 1617 uterine height measurements, from the upper border of the symphysis pubis to the fundus uteri. For the diagnosis of FGR, being considered as positive the exam with measurements below the 10th percentile according to MARTINELLI et al. (2001) curve, the sensitivity (SE), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) were 78,0%, 77,1%, 47,6% and 92,9%, respectively. For the 5th percentile, this curve showed SE= 64,0%, SP= 89,9%, PPV= 62,7% and NPV= 90,4% for the detection of FGR. The BELIZÁN et al. (1978) curve, having the 10th percentile as the limit, yielded SE= 54,0%, SP= 97,3%, PPV= 84,4% and NPV= 88,8% for the identification of FGR. We conclude that, when used for screening FGR, the MARTINELLI et al. (2001) curve showed greater sensitivity and negative predictive value, and presents better results than that of Belizán et al. (1978)
Hernandez, Wagner Rodrigues. "Progesterona natural na prevenção do parto prematuro em gestação gemelar: estudo randomizado, duplo-cego, placebo controlado." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-15032016-115638/.
Повний текст джерелаOBJECTIVE: The purpose of this study was to investigate the use of vaginal progesterone for the prevention of preterm delivery in twin pregnancies. STUDY DESIGN: We conducted a prospective, randomized, double-blind, placebo-controlled trial that involved 390 naturally conceived twin pregnancies among mothers with no history of preterm delivery who were receiving antenatal care at a single center. Women with twin pregnancies between 18 and 21 weeks and 6 days\' gestation were assigned randomly to daily vaginal progesterone (200 mg) or placebo ovules until 34 weeks and 6 days\' gestation. The primary outcome was the difference in mean gestational age at delivery; the secondary outcomes were the rate of spontaneous delivery at < 34 weeks\' gestation and the rate of neonatal composite morbidity and mortality in the treatment and no treatment groups. RESULTS: The baseline characteristics were similar in both groups. The final analysis included 189 women in the progesterone group and 191 in the placebo group. No difference (P .095) in the mean gestational age at delivery was observed between progesterone (35.08 ± 3.19 [SD]) and placebo groups (35.55 ± 2.85). The incidence of spontaneous delivery at < 34 weeks\' gestation was 18.5% in the progesterone group and 14.6% in the placebo group (odds ratio, 1.32; 95% confidence interval, 0.24 - 2.37). No difference in the composite neonatal morbidity and mortality was observed between the progesterone (15.5%) and placebo (15.9%) groups (odds ratio, 1.01; 95% confidence interval, 0.58 -1.75). CONCLUSION: In non-selected twin pregnancies, vaginal progesterone administration does not prevent preterm delivery
Machado, Rita de Cassia Alam. "Gestações gemelares com pesos discordantes: estudo da predição ultra-sonográfica e dos resultados neonatais." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-30012007-094837/.
Повний текст джерелаThe aim of this study was to evaluate the ability of prenatal ultrasound scans to predict fetal growth discordance in twin pregnancies and perinatal morbidity/mortality associated with these cases. This was a retrospective study (1998-2004) involving twin pregnancies that were scanned and had their delivery at our Institution (HCFMUSP). Cases with fetal malformations (n=43) or twin to twin transfusion syndrome (n=24) were excluded. The study of ultrasound scans consisted of 221 twin pregnancies. The final morbidity/mortality study group consisted of 151 twin pregnancies. Birth weight was evaluated based on twin growth charts published by Alexander et al (1998) and weight discordance as a difference >= 20%. Small for gestacional age (SGA) was defined as birth weight below the 10th centile. The study of ultrasonographic prediction of interwin discordance was made using four different intervals between ultrasound examination and delivery (0 to 7 days, n = 96; 8 to 14 days, n = 66; 15 to 21 days, n = 58; 22 to 28 days, n = 59 pregnancies), with a total of 279 ultrasound examinations. In group 0 to 7 days, the sensitivity was 93,6%, specificity was 79,4%, positive predicted values was 89,2%, negative predicted values was 87,1% and accuracy was 88,6%. In the groups 8 to 14 days, 15 to 21 days and 22 to 28 days the sensitivity and accuracy were 95,8% and 84,9%, 95,6% and 84,5%, 90,9% and 84,8%, respectively. Birthweight discordance was observed in 40 sets of twins (26.5%) and 12 cases were monochorionic MC (30%). Twenty five cases (22.5%) in the non discordant group were MC. In the non discordant group, monochorionic pregnancies showed lower gestational age at delivery (34.3 versus 36.2 wks, p=0.004), lower mean birth weight (2067g versus 2334g, p=0.0016) and longer length of stay in hospital (10.6 versus 7.3 days, p=0.0023) compared to dichorionic twins. In the group with twin birthweight discordance, there were no significant differences between MC and DC pregnancies and 75% of the cases had at least one newborn with SGA. These cases were showed lower gestational age at delivery (35.2 versus 36.8wks, p=0.009) and longer length of stay in hospital (17.5 versus 8.2 days, p=0.026). In the discordant group, the smaller twin had a higher frequency of first minute Apgar score < 7 (27.5% versus 7.5%, p=0.01). Perinatal mortality rate was similar in both groups (discordant 4.5% and concordant 3.7%, p=1.0). There were no significant differences in morbidity and mortality between concordant and discordant twins when birth weight was between the 10 th and 90 th centile. In conclusion, there was a good correlation between fetal growth discordance predicted by prenatal scan and actual birth weight discordance. Neonatal morbidity was related to SGA. Excluding fetal malformation and TTTS cases, birth weight discordance in twin pregnancies is not a significantly associated with neonatal mortality.
Nunes, Maria de Fátima Fernandes Pussick. "Fatores associados ao retardo de crescimento intra-uterino em recém nascidos em maternidades públicas da cidade de Salvador-Bahia." Programa de pós-graduação em Saúde Coletiva, 2007. http://www.repositorio.ufba.br/ri/handle/ri/10404.
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Fatores associados ao retardo no crescimento intra-uterino ainda não foram totalmente esclarecidos. Recém-nascidos (RN) pequenos para a idade gestacional (PIG) apresentam alterações nos valores hematológicos comparados aos RN adequados para a idade gestacional (AIG) e pré-termos. Persistem também limitações metodológicas inerentes a acurácia dos métodos de determinação da idade gestacional. Objetivos: Determinar os fatores associados ao RCIU, as características hematológicas dos recém nascidos portadores do RCIU e avaliar a acurácia dos métodos da avaliação da idade gestacional utilizados no diagnóstico antropométrico desses recém-nascidos. Metodologia: Estudo envolvendo puérperas e 564 RN em 2 maternidades públicas da cidade de Salvador. Foram classificados de AIG, RN com o peso ≥10th e <90th, de PIG aqueles com peso <10th, avaliados pela curva de Williams; e pré-termo, aqueles com <37 semanas de gestação. Os dados foram coletados utilizando-se de questionário padronizado. Foram tomadas as medidas antropométricas da criança e da puérpera e coletou-se o sangue do cordão umbilical. A idade gestacional foi calculada pelos métodos da data da última menstruação, ultrassonografia e físico de Capurro. Estudo 1 de desenho caso-controle. Estudos 2 e 3 de desenhos de corte transversal. Análise estatística: No estudo 1, utilizou-se a regressão logística não condicional para testar a associação entre a variável dependente e as preditoras e Odds Ratio foi adotado como medida de associação. No estudo 2, a média e seu respectivo DP, valor máximo e mínimo foram usados para descrever os valores hematológicos do cordão umbilical. Para o estudo 3, realizou-se a diferença entre as medianas da idade gestacional segundo os métodos, utilizando-se do teste não paramétrico “Wilcoxon Signed Rank Test”. A correlação entre as idades gestacional estimadas pelo DUM, USG e Capurro e entre estes métodos e o peso ao nascer foi realizada utilizando-se do coeficiente de correlação de Pearson. Utilizou-se o Coeficiente Kappa para avaliar a concordância entre os métodos na estimação do estado antropométrico do recém-nascido. A validade dos métodos na estimação da idade gestacional foi avaliada por meio do cálculo da sensibilidade, especificidade, VPP, VPN e pela curva ROC. Foram utilizados os pacotes estatístico SPSS.11 e o Stata 8, aceitando-se a significância de 5% nas estimativas de interesse. Resultados: Com o estudo 1, identificou-se que a primeira gestação (OR:2,85; 1,73-4,71), o hábito de fumar (OR: 2,65; 1,35-5,19) e a gestação anterior desfavorável (OR:2.10; 1,21-3,64) se comportaram como fatores de risco para retardo no crescimento intra-uterino. Os resultados do estudo 2 indicaram que valores mais altos de hemácias (4,21×1012/l±0,48), hemoglobina (14,50 g/dl ±1,42), hematócrito (43,50%±4,36), ferritina (162,61 µg/l ±100,10); RDW (13,34±0,85%) e leucócitos (12,82 109/l ±3,39) foram identificados nos RN PIG, quando comparados com aqueles dos AIG a termo e pré-termos. Os RN AIG pré-termos apresentaram valores mais altos de VGM e HGM. Os valores médios das plaquetas foram mais altos nos RN AIG a termo. A partir dos resultados do estudo 3, observou-se que o método de Capurro incrementou a idade gestacional em intervalos menores de 39 semanas e a USG a aumentou a partir deste patamar, em relação ao método DUM. Os métodos DUM e USG apresentaram maior correlação entre a estimativa da idade gestacional e o estado antropométrico para o conjunto dos RN (r=0,668) e para a identificação do RN AIG (r=0,685). Considerando a idade gestacional estimada pelo DUM e a relação com o peso ao nascer, o coeficiente de correlação foi mais elevado (r=0,609) na identificação dos RN PIG’s. Na predição de RN PIG’s, maior sensibilidade foi observada para a USG (96,6%) e maior especificidade para o Capurro (75,5%). Acurácia mais elevada na estimativa da idade gestacional foi observada para a USG na 41ª, tomando como referencia o DUM (ROC=77%). Conclusão: O RCIU associou-se à primeira gestação, à gestação anterior desfavorável e ao hábito de fumar. RN portadores de RCIU apresentaram valores ematológicos mais elevados em relação os RN AIG e pré-termos e o método físico de Capurro apresentou pior desempenho na identificação de RCIU.
Salvador
Lopes, Margareth Corrêa Lima. "Crescimento de recém-nascidos pré-termos tardios nos primeiros seis meses de idade corrigida em Cuiabá-MT." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-24102014-125210/.
Повний текст джерелаIntroduction: The birth of newborns late preterm (RNPT -T), usually treated as \"near term\", has been increasing in recent decades. Several factors are attributed to its etiology and contribute to increased rates of perinatal and infant morbidity and mortality. Currently there are few studies of these newborns, especially about their growth. Objectives: To analyze the growth pattern of late preterm infants from birth to six months of corrected age. Methods: This cohort study included 64 RNPT-T, in four major hospitals in Cuiabá, between January and September 2013 and followed until 6 months corrected age. Data were collected at birth, at 40 weeks, 3 and 6 months corrected age. Correlation analyzes between anthropometric parameters mid- arm circumference (MAC) and triceps skinfold (TS) on the basis of anthropometric indices MAC / HC (head circumference), weight / length (W / L) and body mass index (BMI) were performed multiple linear regression. Results: At birth, 81.3 % were classified as appropriate for gestational age, with the average weight of 2343.80 ± 430.50 g. All newborns had a continuous growth in the six months corrected age for the values of weight, length and head circumference (HC). The average value of TS values of MAC / HC and BMI showed no difference at 6 months of corrected age. All correlation coefficients (r) of the TS and MAC parameters in relation to anthropometric indices showed statistically significant, with the highest values for MAC versus MAC / HC and W / L and lower for MAC versus BMI. At the end of the TS model of multiple linear regression, the MAC / HC contributed significantly to predict the deposition of fat at birth, at 40 weeks and at 3 months\' corrected age (33.8 %, 46.07 % and 18.08 % respectively); at 6 months was the best predictor of the ratio W/ L (10.45%). The best predictor for the MAC was the MAC / HC, which remained in the model with values of 73.71 % at all evaluated times. Conclusion: The parameters weight, length, head circumference and arm - circumference and the ratio W / L increased in the four times of measurement, while the TS and MUAC / HC relations and BMI did not change from the first to the second quarter and MAC / HC was the best predictor of subcutaneous fat deposit triceps (TS) and fat and muscle (MAC) mass
Ivana, Vorgučin. "Praćenje vrednosti insulinu sličnog faktora rasta tip 1 u serumu i brzine rasta tokom terapije hormonom rasta kod dece." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2015. http://www.cris.uns.ac.rs/record.jsf?recordId=95556&source=NDLTD&language=en.
Повний текст джерелаGrowth hormone plays a key role in many physiological processes. The anabolic effects, the stimulation of growth of the long bones and the regulation of gene transcription in the target cells are mediated mainly via mitogenic polypeptide and insulin-like growth factor type 1 (insulin like growth factor 1-IGF-1). Growth hormone induces the production of IGF-1 in the liver, which interacts with receptors of the target organs inducing growth, that is, IGF-1 mediates all the stimulating effects of growth hormone on bone, cartilage, muscle growth and the metabolism of fats and carbohydrates. In assessing the regularity, safety and efficacy of growth hormone therapy, measuring the concentration of IGF-1 in serum is used. The survey was conducted as a retrospective-prospective study and involved 80 patients treated with growth hormone, monitored and treated at the Department of Endocrinology, Diabetes and Metabolic Diseases, at the Institute for Health Protection of Children and Youth of Vojvodina in Novi Sad. Investigated sample included 80 patients, of whom 35 children have growth hormone deficiency, 24 children were born small for gestational age and 21 girls with Turner syndrome. All the patients were monitored from the beginning of the administration of growth hormone and during the first two years of growth hormone therapy. In this study, auxological and laboratory parameters were monitored for the purpose of examining the response to treatment of growth hormone. The basal values of IGF-1 and changes in IGF-1 levels in serum, along with monitoring the rate of growth velocity and recent changes in standard deviation - SSD for body height and bone maturation, were monitored during growth hormone therapy and used for the evaluation of the response to growth hormone therapy. The objectives of the study were to determine the correlation of insulin-like growth factor type 1 values, the growth velocity and maturation of bone during growth hormone therapy. Also, the growth velocity in children with growth hormone deficiency was compared with the growth velocity in girls with Turner syndrome and in children born small for gestational age while treated with growth hormone. Two-year monitoring of growth hormone therapy in the study sample has show n good response to therapy. 71.5% of children with growth hormone deficiency, 79.2% of children born small for gestational age, and 42.9% of girls with Turner syndrome achieved normal body height (± 2 SSDTV) after two years of growth hormone therapy. There was a significant share of children at prepubertal age at the beginning of growth hormone therapy: 77.2% of children with growth hormone deficiency, 79.1% of children born small for gestational age and 90.5% of girls with Turner syndrome, which significantly influenced the success of the therapy. During the growth hormone therapy there was an increase of growth velocity and SSD TV in all three groups of children. An increase in levels of IGF-1 serum and SSDIGF-1 and acceleration of bone maturation were determined in all three groups of patients during growth hormone therapy. For the first six months of therapy there was no statistically significant difference between groups in growth velocity (p> 0.05), while the period of the first and second year of growth hormone therapy showed a statistically significant difference between groups (p <0.05). The growth velocity in girls with Turner syndrome was significantly lower than the growth velocity in children with growth hormone deficiency (p <0.05) and in children born small for gestational age (p <0.05). Between children with growth hormone deficiency and children born small for gestational age there was no statistically significant difference in growth velocity (p> 0.5). By monitoring auxological and laboratory parameters during the two years of application of growth hormone, several highly statistically significant mathematical models for predicting the response to treatment of growth hormone were constructed in this study with a high coefficient of multiple linear correlation. In this study, there was no statistically significant correlation between the level of change in IGF-1 and growth velocity for the entire sample, as well as for children with growth hormone deficiency, children born small for gestational age and girls for Turner syndrome. There was no statistically significant correlation between the level of change in IGF-1 and acceleration of bone maturation for the entire sample and for the three groups of patients.
Angrisani, Rosanna Mariangela Giaffredo. "Estudo eletrofisiológico longitudinal da via auditiva em lactentes nascidos pequenos para a idade gestacional." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5170/tde-12022014-162325/.
Повний текст джерелаThe appropriateness of weight at birth is a risk factor for developmental delays. Prematurity and intrauterine growth restriction (IUGR) are among other causes of morbidity and mortality. The term \"small for gestational age\" (SGA) is often used as an indicator of IUGR, when the fetus may have been subjected to restrictions at different periods of pregnancy. The literature points SGA as a risk for neuropsychological developmental delay, including language. Objective: to monitor the maturation of the auditory pathway in SGA infants, comparing to term and preterm appropriate for gestational age (AGA) infants, through the analysis of the ABR responses to click and tone burst stimulus in the first six months of life. Method: A longitudinal, observational and multicenter study was conducted. A total of 172 SGA and AGA infants, term and preterm, were evaluated in the neonatal period and at three and six months of age through the ABR with click and tone burst stimulus with 0.5 kHz and 1 kHz at 80dBHL. Results: in the neonatal period, the term SGA infants did not differ from term AGA infants for ABR responses. The same was observed between preterm SGA and preterm AGA infants. When comparing the term and preterm SGA groups, there was a difference between the latencies of waves III, V and interpeak intervals (lTPI) I-III and I-V, with longer latencies in preterm SGA; there were no differences with the tone burst stimuli in the analyzed frequencies. When comparing the AGA term and preterm groups, differences were observed on latencies of waves III, V and ITPI III-V and I-V, with longer latencies for preterm infants. There were no differences in the frequencies evaluated with the tone burst stimuli. At three months of age, there were no differences between the term SGA and AGA; when comparing preterm SGA and AGA, differences were found for ITPI III-V, with shorter latencies in preterm SGA. SGA term and preterm infants did not differ; there were differences between term and preterm AGA in latencies of wave V and ITPI I-V. In the third data collection, at six months of age, term SGA and AGA infants significantly differed on latencies of wave III and ITPI I-III, which did not occur when comparing preterm SGA and AGA infants, who differed only regarding ITPI III-V. Significant differences were only observed when comparing term and preterm SGA infants regarding the tone burst stimuli at 0.5 kHz. Conclusion: The findings of this study showed that the maturational process of the auditory pathway in SGA infants occurs at different speed when compared to AGA infants; SGA infants have accelerated maturation, especially in the first three months of age, thus characterizing a recovery period from the hearing standpoint; in the neonatal period, the maturation of the central auditory nervous system is more influenced by prematurity than birth weight; maturation occurred in caudo-rostral direction in the two groups. The ABR with tone burst at 0.5 kHz and 1 kHz evidenced maturational process, but not in such detail as with the click stimuli. The SGA infants should be monitored until at least three years of age
Coletta, Rocio Riatto Della. "Análise das repetições CA do gene IGF1, VNTR do gene da insulina e região promotora P4 do gene IGF2 em indivíduos nascidos pequenos para idade gestacional." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-29042008-144128/.
Повний текст джерелаIntroduction: Polymorphisms in the promoter region of insulin (INS), IGF2 and IGF1 genes may decrease their expression during fetal life and afterward could be related to intra-uterine fetal growth retardation and greater risk of hypospadia development. In post-natal life, decreased expression of these genes can result in lack of stature recovery and in lower IGF1 serum levels in children, as well as in higher risk for type 2 diabetes mellitus and metabolic syndrome in adults. Objectives: The aims of the present study were: (1) to analyze the allelic and the genotypic frequency of the insulin (INS) gene variable number of tandem repeats (VNTR) and the IGF1 gene CA repeats; (2) to analyze the P4 promoter region of IGF2 gene (3) to test the contribution of INS VNTR, IGF1 gene CA repeats on insulin sensitivity and IGF1 serum levels in children born SGA with and without catch up, respectively. Patients: We studied 142 individuals born SGA with catch up (n = 66) and without catch up (n = 76) selected from three different centers (HCFMUSP, Santa Casa de Sao Paulo and HC-UFPR). The control group consisted of 297 children born appropriate for gestational age (AGA). Methods: Extraction of genomic DNA, PCR-amplification of the VNTR of insulin gene, CA repeats of IGF1 and IGF2 gene P4 promoter region; restriction analysis; Genescan software; automatic sequencing. Blood measurements of serum level of glucose, insulin and IGF1. Statistical analysis (Statistical Package for Social Sciences software). Results: Regarding birth parameters, the average of Z-height, Z-BMI (body mass index) and Z-height paternal and Z- EA (target height) were higher in children born SGA who had catch up. Interestingly, we observed that the Z-PC was higher in children born SGA without catch up. In addition, the Z-IGF1 serum levels were significantly higher in children who had catch up (p <0.05). The molecular analysis of IGF1 gene CA repeats and of INS gene VNTR locus did not show a statistically significant difference in the allelic and genotypic distribution of these polymorphisms between adequate for gestational age (AGA) and SGA groups nor between SGA with and without catch up. Similarly, we have not found an association of these polymorphisms with clinical or laboratory variables of this study. A novel polymorphism in the P4 promoter region of the IGF2 gene was identified. It was characterized by cytosine repeats (9-12) at position -1982 before transcription initiation site of exon 2 of IGF2 gene. Yet, we have identified a heterozygous substitution of cytosine for thymine at the nucleotide position 9 in the allele 11C in four children born SGA. This change was also absent in the control population. Quantization of IGF2 gene expression in two of these children did show loss of expression of this gene in patients carrying the variant 9C/T. Conclusions: We have not observed an association of the above described polymorphisms with pre and post natal growth, or with the occurrence of insulin resistance in individuals born SGA. IGF-1 levels did not seem to be associated with the polymorphisms either. A new variant in the P4 promoter region of IGF2 gene was identified, however preliminary studies showed no influence on intra-uterine growth.
Vieira, Valérie Gonçalves. "The golden hour in infants <29 weeks of gestational age." Master's thesis, 2019. https://hdl.handle.net/10216/120817.
Повний текст джерелаFerreira, Joana Maria Soares. "The golden hour in Infants <32 weeks of gestational age." Master's thesis, 2015. https://hdl.handle.net/10216/78867.
Повний текст джерелаFerreira, Joana Maria Soares. "The golden hour in Infants <32 weeks of gestational age." Dissertação, 2015. https://hdl.handle.net/10216/78867.
Повний текст джерелаVieira, Valérie Gonçalves. "The golden hour in infants <29 weeks of gestational age." Dissertação, 2019. https://hdl.handle.net/10216/120817.
Повний текст джерелаDurães, Maria Inês da Cunha. "Morbidity and mortality of preterm infants less than 26 weeks of gestational age." Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/89361.
Повний текст джерелаMarques, Beatriz Lousa Alves Riquito. "Morbidity and mortality in preterm infants less than 29 weeks of gestational age." Master's thesis, 2018. https://hdl.handle.net/10216/112050.
Повний текст джерелаDurães, Maria Inês da Cunha. "Morbidity and mortality of preterm infants less than 26 weeks of gestational age." Dissertação, 2016. https://repositorio-aberto.up.pt/handle/10216/89361.
Повний текст джерелаMarques, Beatriz Lousa Alves Riquito. "Morbidity and mortality in preterm infants less than 29 weeks of gestational age." Dissertação, 2018. https://hdl.handle.net/10216/112050.
Повний текст джерелаCampos, Patrícia Isabel Azevedo. "Prenatal Corticosteroids and Respiratory Distress Syndrome Prevention in Infants less than 35 Weeks of Gestational Age." Master's thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/78938.
Повний текст джерелаParente, Carina Sofia Beleza. "Factors associated with long-term mechanical ventilation in preterm infants <29 weeks of gestational age." Master's thesis, 2019. https://hdl.handle.net/10216/119926.
Повний текст джерелаCampos, Patrícia Isabel Azevedo. "Prenatal Corticosteroids and Respiratory Distress Syndrome Prevention in Infants less than 35 Weeks of Gestational Age." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/78938.
Повний текст джерелаParente, Carina Sofia Beleza. "Factors associated with long-term mechanical ventilation in preterm infants <29 weeks of gestational age." Dissertação, 2019. https://hdl.handle.net/10216/119926.
Повний текст джерелаDossal, Sanam [Verfasser]. "Long-term follow-up of preterm infants with gestational age below 33 weeks of gestation born in the year 1999 / vorgelegt von Sanam Dossal." 2009. http://d-nb.info/1002066808/34.
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