Дисертації з теми "Genomics and transcriptomics"
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Burnham, Katie. "Functional genomics of the sepsis response." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:cb98af40-1b66-4966-a643-ae8dfec2c122.
Повний текст джерелаKrishnan, Vandhana. "Computational approaches for comparative genomics and transcriptomics using 454 sequencing technology." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Summer2009/v_krishnan_072409.pdf.
Повний текст джерелаTitle from PDF title page (viewed on Aug. 12, 2009). "School of Electrical Engineering and Computer Science." Includes bibliographical references (p. 80-87).
Jiang, Xiaofang. "Genomics and Transcriptomics Analysis of the Asian Malaria Mosquito Anopheles stephensi." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/79959.
Повний текст джерелаPh. D.
Ghobakhlou, Abdollah. "Genomics, Transcriptomics and Metabolomics of cold adaptation in arctic Mesorhizobium sp. N33." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/29489/29489.pdf.
Повний текст джерелаLee, Kevin Joseph. "Transcriptomics of malaria host-pathogen interactions in primates." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54264.
Повний текст джерелаBohnert, Regina [Verfasser], and Gunnar [Akademischer Betreuer] Rätsch. "Computational Methods for High-Throughput Genomics and Transcriptomics / Regina Bohnert ; Betreuer: Gunnar Rätsch." Tübingen : Universitätsbibliothek Tübingen, 2011. http://d-nb.info/1162699280/34.
Повний текст джерелаNelson, A. D. L., E. S. Forsythe, U. K. Devisetty, D. S. Clausen, A. K. Haug-Batzell, A. M. R. Meldrum, M. R. Frank, E. Lyons, and M. A. Beilstein. "A Genomic Analysis of Factors Driving lincRNA Diversification: Lessons from Plants." GENETICS SOCIETY AMERICA, 2016. http://hdl.handle.net/10150/621708.
Повний текст джерелаHearn, Jack. "Exploring population history and gall induction in cynipid gall wasps using genomics and transcriptomics." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/8925.
Повний текст джерелаCortes, Bermudez Diego Fernando. "Functional genomics through metabolite profiling and gene expression analysis in Arabidopsis thaliana." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28457.
Повний текст джерелаPh. D.
Xue, Xia. "Genomics and Transcriptomics of Antarctic Nematodes Reveal Drivers of Life History Evolution and Genome Evolution." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7422.
Повний текст джерелаVijay, Nagarjun. "Speciation genomics : A perspective from vertebrate systems." Doctoral thesis, Uppsala universitet, Evolutionsbiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265342.
Повний текст джерелаNelson, Andrew D. L., Upendra K. Devisetty, Kyle Palos, Asher K. Haug-Baltzell, Eric Lyons, and Mark A. Beilstein. "Evolinc: A Tool for the Identification and Evolutionary Comparison of Long Intergenic Non-coding RNAs." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/624658.
Повний текст джерелаGerrard, Diana Lea. "Characterization Of Epigenetic Plasticity And Chromatin Dynamics In Cancer Cell Models." ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1060.
Повний текст джерелаLahrmann, Urs [Verfasser], and Alga [Akademischer Betreuer] Zuccaro. "Genomics and Transcriptomics of the sebacinoid fungi Piriformospora indica and Sebacina vermifera / Urs Lahrmann. Betreuer: Alga Zuccaro." Marburg : Philipps-Universität Marburg, 2014. http://d-nb.info/1051934826/34.
Повний текст джерелаGibbons, Justin Allan. "Genomics and Transcriptomics Approaches to Understanding Drug Resistance Mechanisms in the Malaria Parasite Plasmodium falciparum." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7794.
Повний текст джерелаLAMONTANARA, ANTONELLA. "Sviluppo ed applicazione di pipilines bioinformatiche per l'analisi di dati NGS." Doctoral thesis, Università Cattolica del Sacro Cuore, 2015. http://hdl.handle.net/10280/6068.
Повний текст джерелаThe advance in sequencing technologies has led to the birth of sequencing platforms able to produce gigabases of sequencing data in a single run. These technologies commonly referred to as Next Generation Sequencing or NGS produce millions of short sequences called “reads” generating large and complex datasets that pose several challenges for Bioinformatics. The analysis of large omics dataset require the development of bioinformatics pipelines that are the organization of the bioinformatics tools in computational chains in which the output of one analysis is the input of the subsequent analysis. A work of scripting is needed to chain together a group of existing software tools.This thesis deals with the methodological aspect of the data analysis in NGS sequencing performed with the Illumina technology. In this thesis three bioinformatics pipelines were developed.to the following cases of study: 1) a global transcriptome profiling of “Oleaeuropeae” during cold acclimation, aimed to unravel the molecular mechanisms of cold acclimation in this species; 2) a SNPs profiling in the transcriptome of two cattle breeds aimed to produce an extensive catalogue of SNPs; 3) the genome sequencing, the assembly and annotation of the genome of a Lactobacillus plantarum strain showing probiotic properties.
Domènech, Salgado Laura 1989. "A Comprehensive multiomics approach towards understanding obsessive-compulsive disorder." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665800.
Повний текст джерелаFins a dia d’avui, s’ha avançat molt poc a l’hora d’elucidar les causes genètiques del trastorn obsessiu compulsiu (TOC). En aquest projecte hem realitzat estudis d’associació de variants rares (RVAS) i anàlisis de transcriptòmica i metagenòmica per centrar-nos en àrees relativament poc explorades del TOC. Hem identificat i replicat un enriquiment de variants rares a TMEM63A, un gen que codifica un canal catiònic permeable per calci, a través d’anàlisis de seqüenciació de l’exoma complet, RVAS i reseqüenciació dirigida. A més, hem observat una sobrerepresentació de gens enriquits en variants rares en casos de TOC relacionats amb la senyalització de calci. Els estudis de transcriptòmica han identificat una expressió diferencial de gens involucrats en el desenvolupament i la funció neuronal en els pacients de TOC. La integració dels resultats dels nostres estudis de RVAS i transcriptòmica també revelen un possible paper de les semaforines i del guiatge axonal al TOC. Finalment, els estudis de metagenòmica han confirmat el increment prèviament reportat de la família bacterial Rikenellaceae en el microbioma intestinal i han mostrat una relació significativa més alta d’Actinobacteris/Fusobacteris en el microbioma de l’orofaringe dels pacients de TOC. Els nostres resultats fomenten activament la recerca en aquestes àrees.
Mercurio, Kevin Jay Belarmino. "Identifying Genes Required for Saccharomyces cerevisiae Growth in Mucin." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40546.
Повний текст джерелаHanson, Sara Jeanette. "The molecular evolution of reproduction in animals: insights from sexual and asexual rotifers." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1618.
Повний текст джерелаHuang, Yun [Verfasser]. "Combining genomics and transcriptomics to study adaptation to lake and river habitats in three-spined sticklebacks / Yun Huang." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1152264176/34.
Повний текст джерелаLachance, Hannah. "Cisco Science: Using Omics To Answer A Range Of Key Questions." ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1135.
Повний текст джерелаChai, Hui Hui. "Developing new approaches for transcriptomics and genomics : using major resources developed in model species for research in crop species." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/14246/.
Повний текст джерелаGapp, Bianca. "Functional genomics and compound mode-of-action screening in haploid human cells." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:0c2ce8f8-15f3-447f-9117-8953329bd4ac.
Повний текст джерелаCortese, Diego. "Genomic and transcriptomic sequencing in chronic lymphocytic leukemia." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303703.
Повний текст джерелаChenevert, Madeline M. "A Transcriptomic Exploration of Hawaiian Drosophilid Development and Evolution." ScholarWorks@UNO, 2019. https://scholarworks.uno.edu/td/2687.
Повний текст джерелаRichly, Erik. "Structural and functional genomics in semi-autonomous organelles composition and origin of proteomes of chloroplasts and mitochondria and related transcriptomics /." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969512104.
Повний текст джерелаRogl, Kimberley. "A genomics perspective of species and speciation in an Atyid shrimp (Paratya australiensis)." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/207248/1/Kimberley_Rogl_Thesis.pdf.
Повний текст джерелаJeffery, N. "Beta cell differentiation status in Type 2 Diabetes." Thesis, University of Exeter, 2019. http://hdl.handle.net/10871/35724.
Повний текст джерелаLebreton, Annie. "Caractéristiques génomiques du genre fongique Mucor et évolution adaptative liée à différents modes et conditions de vie au sein du genre." Thesis, Brest, 2018. http://www.theses.fr/2018BRES0098/document.
Повний текст джерелаThe genus Mucor belongs to the phylum Mucoromycota; a group that derived from the lineages that diverged early in the evolution of fungal species (early diverging lineages). These groups have been less well studied and are less well understood in comparison to Ascomycetes and Basidiomycetes. The genus Mucor is composed of saprophytic species, but also encompasses species with diverse lifestyles.For example, it includes plant endophytes (such as M. endophyticus) or opportunistic animal pathogens (such as the thermophilic species M. circinelloides or M. indicus). The genus is ubiquitous but there are some associations with specific habitats which seem to indicate specialisation. The aim of this thesis is to better understand the genetic potential of the genus Mucor in particular, to decipher how it maintains this ubiquitous lifestyle, its capacity to adapt to diverses habitats and to better understand the existence within the genus of species that may have undergone specialization allowing them to preferentially or exclusively colonise certain habitats, such as cheese. In order to achieve this, we have performed comparative transcriptomic and genomic studies in order to determine the main structural and functional characteristics of the Mucor genomes, identify similarities among the species studied and also assess whether there exist specific genetic associations with lifestyle/habitat and determine whether the species frequently found in cheese (in particular those species considered as technological) harbour imprints of adaptation or even domestication
Logotheti, Marianthi. "Integration of functional genomics and data mining methodologies in the study of bipolar disorder and schizophrenia." Doctoral thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-52644.
Повний текст джерелаSchwientek, Patrick [Verfasser]. "Genomics and transcriptomics of the industrial acarbose producer Actinoplanes sp. SE50/110 / Patrick Schwientek. Technische Fakultät. Centrum für Biotechnologie - Institut für Genomforschung und Systembiologie." Bielefeld : Universitätsbibliothek Bielefeld, Hochschulschriften, 2012. http://d-nb.info/102095454X/34.
Повний текст джерелаRuffing, Anne M. "Metabolic engineering and omics analysis of Agrobacterium sp. ATCC 31749 for oligosaccharide synthesis." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/39507.
Повний текст джерелаPieta, Luiza. "Genômica de listeria monocytogenes e transcriptômica do microrganismo na presença de óleo essencial extraído de baccharis psiadioides." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/163557.
Повний текст джерелаLLiisstteerriiaa mmoonnooccyyttooggeenneess is a Gram-positive rod-shaped microorganism, facultative anaerobic, psychrotrophic, pathogenic to humans and transmitted by food. It causes listeriosis, a severe disease that affects specific risk groups such as elderly, immunocompromised, pregnant women, children and newborns. In this study, differential expression of LL.. mmoonnooccyyttooggeenneess in the presence of essential oil extracted from BBaacccchhaarriiss ppssiiaaddiiooiiddeess, a plant from AAsstteerraacceeaaee family popularly named as "alecrim-do-campo", "vassoura" or "erva formiga" used by population as a medicinal plant, was investigated. In addition, the genomes of two different LL.. mmoonnooccyyttooggeenneess serotypes, often associated with listeriosis outbreaks, were sequenced through the MiSeq Illumina platform. These sequences were deposited in GenBank and compared with reference genomes. Prior to the execution of genomic and transcriptomic analyzes, composition of the essential oil extracted from BB.. ppssiiaaddiiooiiddeess used in the experiments was determined by gas chromatography with mass spectrometer (GC-MS), which demonstrated a higher amount of β-pinene in the fraction composed mainly by monoterpenes. This compound is often found in aromatic medicinal plants and also pointed as one of those responsible for their antimicrobial potential. The other results obtained in the present study indicate that the essential oil tested has a potential bacteriostatic activity at the concentration studied, and genes related to the virulence of the microorganism were less transcribed in its presence, contrary to what was observed for stress response genes, which presented higher transcription levels on that condition. Comparative genomics between the bacterial genomes sequenced in this work and the reference strains suggests a higher number of proteins expressed in LL.. mmoonnooccyyttooggeenneess serotype 4b related to the defense and metabolism of the microorganism, indicating mechanisms that may be involved with the greater ability of this serotype to cause human listeriosis.
Lee, Bo-Hyung. "High thoughput study of biofilm and virulence in Listeria monocytogenes using innovative approaches." Thesis, Université Clermont Auvergne (2017-2020), 2019. http://www.theses.fr/2019CLFAC017.
Повний текст джерелаConditions and proliferation in a wide range of environments from soil to mammalian host cells. The genetic heterogeneity in L. monocytogenes is reflected on its diversified clonal structure which correlates, to some extent, with phenotypic traits such as virulence or stress resistance. The thesis investigated two most prominent phenotypes, biofilm formation and virulence potential, from various perspectives using state-of-the art technologies. Throughout the studies, large panels of isolates were used to represent the intraspecific diversity. Unfavourable stimuli such as cold shock and nutrient deprivation induced bacterial adhesion step. Addition of NaCl to growth cultures stimulated biofilm production and, surprisingly, it significantly intensified biofilm maturation of nutrient-deprived cells. High degree of variation in relative biofilm productivity was observed among serotypes, genotypes, as well as isolates across culture conditions, however, certain genotype (clonal complex 26) revealed distinctively higher biofilm production under cold temperature (10°C) suggesting an association of genotype with biofilm phenotype. Pan-GWAS identified a number of genes among which those implicated in functions such as ‘transformation/competence’, ‘phage-related genes’, and ‘metabolism of phosphate’ will need further investigations for their roles in biofilm formation. RNA sequencing analysis revealed high intraspecific heterogeneity in basal transcriptome profiles that featured the role of regulatory network including certain transcriptional factors with key roles in virulence such as σB, PrfA, and CodY. The transcriptomic plasticity between lineage I and II as well as hyper- and hypovirulent genotypes supported the evolutionary and epidemiological characteristics of L. monocytogenes. Moreover, the central metabolic pathway was implicated in the infection in Galleria mellonella model system. Conclusively, the thesis explored intraspecific diversity in L. monocytogenes and resulted in ample phenotypic, genomic, and transcriptomic findings. With the integrative omics approach in listeriology, the present work will contribute to unveiling the physiology and pathogenesis of the bacterium
Siqueira, Franciele Maboni. "Análise genômica e transcricional comparativa de Mycoplasma hyopneumoniae, Mycoplasma flocculare e Mycoplasma hyorhinis." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/143434.
Повний текст джерелаMycoplasma hyopneumoniae, Mycoplasma hyorhinis and Mycoplasma flocculare are able to adhere and to colonize the swine respiratory tract. While M. flocculare presence is virtually assymptomatic, M. hyopneumoniae and M. hyorhynis infections may cause respiratory disease. M. hyopneumoniae is the causative agent of swine enzootic pneumonia and M. hyorhynis may affect the lungs and other sites in a diversity of hosts and has been related to arthritis, poliserosites and to the development of several types of human cancer. Despite genomics technological advances, there are very few data about the possible role of M. flocculare in the swine respiratory tract. Moreover, little information about gene transcription is available in these species, despite the importance of these microorganisms. In this work the genome sequences of M. flocculare and a new isolate of M. hyopneumoniae are presented. A comparative genomic analyzes was performed to identify possible characteristics that may help to explain the different behaviors of these species in the swine respiratory tracts. Furthermore, a transcriptome map of each species was performed and a comparative transcriptional profile analysis between M. hyopneumoniae, M. flocculare and M. hyorhynis was undertaken to identify the exclusive features for each of the transcriptional maps, in addition to understanding the coordination mode of gene transcription in Mycoplasma. In general, the three Mycoplasma species that inhabit the swine respiratory tract have a similar gene composition as well as the abundance of transcripts. The transcriptome maps showed that most of the predicted genes are transcribed from these Mycoplasma genomes, as well as some intergenic regions. M. hyopneumoniae and M. flocculare present very similar gene content and transcriptional profile. However, an important difference between these two species is related to the exclusive presence of genes and transcripts of some specific adhesins. M. hyorhynis presents exclusive genes and transcripts that have been related to its invasiveness, mutation rate and infection of different sites. Finally, the comparative analysis of the genomes and transcriptional maps between M. hyopneumoniae, M. flocculare and M. hyorhynis have resulted in a large amount of information, which are important for future studies of the molecular characterization, as transcriptional regulation in the Mycoplasma spp.
Terhoeven, Niklas [Verfasser], Jörg [Gutachter] Schultz, Rainer [Gutachter] Hedrich, and Dirk [Gutachter] Becker. "Genomics of carnivorous Droseraceae and Transcriptomics of Tobacco pollination as case studies for neofunctionalisation of plant defence mechanisms / Niklas Terhoeven ; Gutachter: Jörg Schultz, Rainer Hedrich, Dirk Becker." Würzburg : Universität Würzburg, 2020. http://d-nb.info/1220227978/34.
Повний текст джерелаUllrich, Sophie. "Genomic and transcriptomic characterization of novel iron oxidizing bacteria of the genus “Ferrovum“." Doctoral thesis, Technische Universitaet Bergakademie Freiberg Universitaetsbibliothek "Georgius Agricola", 2016. http://nbn-resolving.de/urn:nbn:de:bsz:105-qucosa-205981.
Повний текст джерелаCamprubí, Font Carla. "Genetics and transcriptomics of adherent-invasive Escherichia coli (AIEC): new approaches to uncover molecular markers for its rapid identification." Doctoral thesis, Universitat de Girona, 2019. http://hdl.handle.net/10803/672302.
Повний текст джерелаEl patotip adherent-invasiu d’Escherichia coli (AIEC) podria jugar un paper en el transcurs de la malaltia de Crohn. Aquest es caracteritza per tenir capacitat d’adhesió i invasió a cèl·lules de l’epiteli intestinal a més de replicar-se i sobreviure en macròfags. Actualment la única manera d’identificar aquests bacteris és analitzant aquestes característiques fenotípiques, un mètode poc estandarditzat i que requereix molt temps i dedicació. En la present tesi ens hem centrat en estudiar genèticament el patotip AIEC per tal de buscar característiques clau que puguin ajudar en el desenvolupament d’una eina molecular per a la seva identificació. En resum, els resultats d'aquest treball proporcionen informació significativa que contribueix a la comprensió de la genètica del patotip AIEC. En aquest cas, s'han presentat dos possibles marcadors moleculars resultants d'una combinació de característiques genètiques i/o fenotípiques que podrien ajudar en la detecció d’AIEC. Finalment, els resultats d'expressió gènica proporcionen noves idees per descriure millor els gens implicats en la virulència del patotip AIEC
Programa de Doctorat en Biologia Molecular, Biomedicina i Salut
Ebenezer, ThankGod Echezona. "The genome of Euglena gracilis : annotation, function and expression." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275885.
Повний текст джерелаKincaid, Smith Julien. "Modification des traits d'histoire de vie au cours de l’hybridation et analyse des mécanismes moléculaires sous- jacents chez les parasites plathelminthes du genre Schistosoma." Thesis, Perpignan, 2018. http://www.theses.fr/2018PERP0028/document.
Повний текст джерелаGlobal changes contribute in modifying species geographical distribution. New interactions between species that have never been in contact before can potentially lead to atypical cases of reproduction, including hybridization. This phenomenon can have strong epidemiological consequences as it can potentially lead to the genesis of hybrid pathogens. The combination of genetic material of distinct species can confer increased capacities to the offspring (hybrid vigor or heterosis), eventually leading to adaptive changes and the emergence of pathogens in non-endemic areas, making them an emerging global threat. This thesis work focuses on schistosomiasis, the second human parasitic disease after malaria and its recent emergence in Europe (Corsica, France). After the identification and genomic characterization of a hybrid parasite between two distinct agents of the disease, S. haematobium in humans and S. bovis in cattle, we conducted an integrative approach to characterize at several scales the invasive capacities and virulence of such parasites. Starting from the field, we set up an experimental evolution protocol aimed at generating first- and second-generation hybrids in the laboratory. We analysed life history trait modifications of these parasites as well as the molecular consequences (genomics and transcriptomics) of this "genomic clash" and we show that hybridization can be a major evolutionary force for parasites
Nikolayeva, Iryna. "Network and machine learning approaches to dengue omics data." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB032/document.
Повний текст джерелаThe last 20 years have seen the emergence of powerful measurement technologies, enabling omics analysis of diverse diseases. They often provide non-invasive means to study the etiology of newly emerging complex diseases, such as the mosquito-borne infectious dengue disease. My dissertation concentrates on adapting and applying network and machine learning approaches to genomic and transcriptomic data. The first part goes beyond a previously published genome-wide analysis of 4,026 individuals by applying network analysis to find groups of interacting genes in a gene functional interaction network that, taken together, are associated to severe dengue. In this part, I first recalculated association p-values of sequences polymorphisms, then worked on mapping polymorphisms to functionally related genes, and finally explored different pathway and gene interaction databases to find groups of genes together associated to severe dengue. The second part of my dissertation unveils a theoretical approach to study a size bias of active network search algorithms. My theoretical analysis suggests that the best score of subnetworks of a given size should be size-normalized, based on the hypothesis that it is a sample of an extreme value distribution, and not a sample of the normal distribution, as usually assumed in the literature. I then suggest a theoretical solution to this bias. The third part introduces a new subnetwork search tool that I co-designed. Its underlying model and the corresponding efficient algorithm avoid size bias found in existing methods, and generates easily comprehensible results. I present an application to transcriptomic dengue data. In the fourth and last part, I describe the identification of a biomarker that detects dengue severity outcome upon arrival at the hospital using a novel machine learning approach. This approach combines two-dimensional monotonic regression with feature selection. The underlying model goes beyond the commonly used linear approaches, while allowing controlling the number of transcripts in the biomarker. The small number of transcripts along with its visual representation maximize the understanding and the interpretability of the biomarker by biomedical professionals. I present an 18-gene biomarker that allows distinguishing severe dengue patients from non-severe ones upon arrival at the hospital with a unique biomarker of high and robust predictive performance. The predictive performance of the biomarker has been confirmed on two datasets that both used different transcriptomic technologies and different blood cell subtypes
Arista, Gautier. "Génomique comparative et fonctionnelle de familles de gènes liés au métabolisme secondaire de la vigne (Vitis vinifera) et de ses proches parents." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ010/document.
Повний текст джерелаGrapevine (Vitis vinifera) has a particularly rich secondary metabolism, giving rise to a wide range of molecules, some of which are involved in defences against pathogens and others in the great diversity of aromas that make wines famous. Analysis of grapevine reference genome has shown a remarkable expansion of certain families of genes linked to secondary metabolism in comparison with the other plants. In this work, I have analysed gene families coding for cytochromes P450, some of them being involved in the production of aromas, genes coding for stilbene synthases (STS), endo-β-1,3-glucanases and NBS type resistance genes involved in grapevine defences. My thesis intends to propose hypothesis to explain the structural organisation of these families and therefore better understand why some of these families are amplified in the grapevine genome. Bioinformatic approaches have been used to study these different genes families. The cytochromes P450 and R genes of NBS type were manually annotated to improve the knowledge of these families of genes. The expression of endo-β-1,3-glucanases, STS and cytochromes P450 genes has been quantified using a large-scale transcriptomic approach. To this purpose, a tool has been developed during this thesis to estimate the level of genes expression from RNA- Seq data available in public databases. In the meantime, DNA resequencing data from 56 cultivars and grapevine species have been analysed to identify structural variations of CNV types within the genes with a NBS domain and the STS genes. These works showed that the amplification of the gene families of interest was not specific to the reference genome but occurred at the scale of the Vitis genus, but also to highlighted structural variations in different genomes. Regarding the STS genes, blocks of duplication and more conserved and expressed genes were identified. For the genes with NBS domain, a clustered organisation has been highlighted with some clusters varying more than others in the studied genotypes. These works contribute to a better knowledge of gene families for efficient and durable defence against pathogens and optimal aromas synthesis in grapevine. This knowledge will benefit to breeding programs currently in progress at INRA Colmar
Mittal, Vinay K. "Detection and characterization of gene-fusions in breast and ovarian cancer using high-throughput sequencing." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54014.
Повний текст джерелаSuarez, Ulloa Maria Victoria. "Transcriptomic and Epigenetic Responses to Environmental Stress in Marine Bivalves with a Focus on Harmful Algal Blooms." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3461.
Повний текст джерелаRahi, Md Lifat. "Understanding the molecular basis of adaptation to freshwater environments by prawns in the genus Macrobrachium." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/118051/1/8741018_md_lifat_rahi_thesis.pdf.
Повний текст джерелаHulur, Imge, Eric R. Gamazon, Andrew D. Skol, Rosa M. Xicola, Xavier Llor, Kenan Onel, Nathan A. Ellis, and Sonia S. Kupfer. "Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci." BioMed Central Ltd, 2015. http://hdl.handle.net/10150/610285.
Повний текст джерелаMartínez, Enguita David. "Identification of personalized multi-omic disease modules in asthma." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-15987.
Повний текст джерелаStranneheim, Henrik. "Enabling massive genomic and transcriptomic analysis." Doctoral thesis, KTH, Genteknologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-45957.
Повний текст джерелаQC 20111115
Lemée, Jean-Michel. "Au delà des frontières du glioblastome : caractérisation de la zone péritumorale des glioblastomes." Thesis, Angers, 2015. http://www.theses.fr/2015ANGE0001/document.
Повний текст джерелаGlioblastoma (GB) is a heterogeneous andaggressive tumor, before which therapeutic options arelimited. The study of the macroscopically normalperitumoral brain zone (PBZ) of GB is essential tounderstand its mechanisms of progression andrecurrence.The first objective of this thesis work was tocompare the transcriptomic and proteomic data from theGB tumor area obtained through the “Grand Ouest”glioma Project. The concordance rate between the 2modalities is low. However, one of the common featureis the dysregulation of neurofilament light polypeptide,which could serve as a biomarker potential of GB.The second objective of this thesis was thecharacterization of the PBZ. We have shown that thisarea, similar at first glance to that of healthy braintissue, is not a simple transition area between the GBand healthy brain tissue but a specific entity withcharacteristics of its own. For example, the ZMNpresents a particular phenotype of infiltrating GB cellsand stromal cells and a surexpression of CRYAB andH3F3A proteins.This thesis work was also an opportunity todevelop new intraoperative imaging techniques of thePBZ, with the aim to assess the presence of a tumoralinfiltration and optimize the quality of the surgicalresection.The characterization of this PBZ allows us tobetter understand its involvement in tumorigenesis andthe presence of specific characteristics of this areaopens the door for the detection of specific biomarkersand the development of targeted therapies.This thesis work was led to 2 publications, 2articles submitted and a patent being evaluated andredacted by a patent office
Pratte, Zoe A. "Investigating the Driving Mechanisms Behind Differences in Bleaching and Disease Susceptibility Between Two Scleractinian Corals, Pseudodiploria Strigosa and Diploria Labyrinthiformis." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2217.
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