Дисертації з теми "Genomic HLA"
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Aldener-Cannavá, Anna. "HLA polymorphism : genomic typing and impact on unrelated stem cell transplantation /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4593-4/.
Повний текст джерелаMandage, Rajendra 1984. "Understanding interactions between EBV and human genomic variation." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/586328.
Повний текст джерелаPimentel-Santos, Fernando Manuel. "Ankylosing spondylitis: genomic and functional characterization of candidate genes and their repercussion in clinical practice." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2012. http://hdl.handle.net/10362/7806.
Повний текст джерелаMendes, Fábio Henrique Kuriki. "Seleção natural em genes HLA e seu efeito sobre regiões adjacentes do genoma." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-02082013-161104/.
Повний текст джерелаThe MHC is a genomic region that contains genes with a central role in the adaptive immune response. Genes in the MHC region, in particular the HLA genes of humans, are involved in the differential susceptibility and resistance to infectious diseases, predisposition to autoimmune diseases and the rejection of transplanted organs. These findings have fueled a series of studies on patterns of genetic variation at HLA genes, which have conclusively demonstrated that their variation deviates from neutral expectations. Such strong evidence of natural selection, with few counterparts in the remainder of the human genome, raise a series of questions concerning the specific evolutionary forces acting on this region and their genomic implications for the evolution of the region as a whole. This work investigates how natural selection affects and is affected by the diversity of genes that are physically linked to those that are units of selection. Our expectation is that strong selection on HLA genes may interfere with the efficacy of selection in removing deleterious variants at closely linked loci. Specifically, by using functional annotations of genetic variants, we test whether sets of genes physically linked to the strongly selected HLA loci show a higher diversity than would be expected in the absence of balancing selection and genetic hitchhiking caused by it, and if this diversity is enriched for putatively deleterious variants. By analyzing the ratio of nonsynonymous to synonymous polymorphisms (and several related statistics) we were able to show that loci close to HLA genes are harboring an excess of nonsynonymous (and hence potentially deleterious) variation. The deleteriousness was confirmed by employing Polyphen 2 - a software that uses nucleotide sequence conservation and protein structure information to classify variants as deleterious or not - and computing statistics such as Pdel/Pn and Pdel/Ps. According to McDonald-Kreitman tests and the Neutrality Index, however, part of this putatively deleterious variation reaches fixation over long timespans, suggesting that selection at the HLA genes may be interfering with both the transient patterns of polymorphism and substitution processes
Landry, Jonathan [Verfasser], and Stefan [Akademischer Betreuer] Wölfl. "The genomic and transcriptomic landscape of HeLa cells / Jonathan Landry. Betreuer: Stefan Wölfl." Heidelberg : Universitätsbibliothek Heidelberg, 2012. http://d-nb.info/1061054462/34.
Повний текст джерелаXu, Huaigeng. "Targeted Disruption of HLA genes via CRISPR-Cas9 generates iPSCs with Enhanced Immune Compatibility." Kyoto University, 2019. http://hdl.handle.net/2433/242420.
Повний текст джерелаOhadi, Mina. "Genome mapping of a locus for familial haemophagocytic lymphohistiocytosis." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314048.
Повний текст джерелаBianchi, I. "LE BASI GENETICHE DELLA CIRROSI BILIARE PRIMITIVA: DAGLI STUDI DI ASSOCIAZIONE SU SINGOLO GENE AGLI STUDI SULL'INTERO GENOMA." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/151770.
Повний текст джерелаFries, Jonna. "Hela Jaget : en analys av Anna Rydstedts Genom nålsögat." Thesis, Växjö University, School of Humanities, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:vxu:diva-1061.
Повний текст джерелаGregoracci, Gustavo Bueno. "Terapia experimental com bacteriófagos." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317028.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-19T03:47:25Z (GMT). No. of bitstreams: 1 Gregoracci_GustavoBueno_D.pdf: 6197096 bytes, checksum: 05eb5e18d8084e5c5f742c6ec5afd63d (MD5) Previous issue date: 2010
Resumo: Bacteriófagos são vírus que infectam bactérias e arqueias, representando as entidades biológicas mais abundantes do mundo e influenciando de maneira marcante populações naturais de seus hospedeiros. A terapia com bacteriófagos, que representa uma das primeiras formas modernas de combate a infecções bacterianas, foi recentemente redescoberta e vem sendo reavaliada seguindo metodologias atuais quanto à sua viabilidade terapêutica. Para completar a caracterização dos fagos de nossa coleção, sequenciamos completamente o genoma da maior parte destes, através da metodologia multiplex pair-ended utilizando a plataforma Illumina. Visando contribuir para verificação da viabilidade terapêutica de bacteriófagos testamos os efeitos protetor e terapêutico dos fagos Shfl1, Saen1v2 e Saen1v4, pertencentes à coleção de nosso laboratório, em modelos biológicos relevantes. O fago Shfl1, lítico contra Shigella flexneri, foi testado em ensaio de invasão em células HeLa. A redução de bactérias intracelulares foi mensurada independentemente através de plaqueamento e citometria de fluxo, além da observação direta por microscopia de fluorescência. O fago Saen1v2, lítico contra Salmonella Typhimurium, foi estudado quanto à biodistribuição e meia-vida em modelo murino, e uma variante viral com maior persistência in vivo foi selecionada. Essa variante, denominada Saen1v2p5, e o fago Saen1v4, lítico contra Salmonella Typhi, foram testados em modelo murino de infecção tifoide, contra seus respectivos hospedeiros. Encontramos similaridade genômica a fagos conhecidos, como T4, T7, T1 entre outros, em maior ou menor grau. Obtivemos um efeito protetor e terapêutico contra Shigella flexneri utilizando o fago Shfl1 em ensaio de invasão em cultura de células HeLa, verificado por todas as metodologias empregadas. Não verificamos efeito antimicrobiano in vivo do fago Saen1v2p5 em modelo murino de infecção por Salmonella Typhimurium. Por outro lado, observamos efeito terapêutico e protetor dose dependente utilizando o fago Saen1v4 em modelo murino de infecção por Salmonella Typhi. O sucesso obtido com baixas multiplicidades de infecção sugere um possível efeito indireto ou estimulação imune inespecífica
Abstract: Bacteriophages are viruses that infect Bacteria and Achaea, representing the most abundant biological entities in the world and markedly influencing natural host populations. Phage therapy, which represents one of the first modern ways to fight bacterial infections, was recently rediscovered and is being re-evaluated according to current methodologies regarding its therapeutic viability. In order to complete phage characterization in our collection, we sequenced completely the genomes of most of these, through the multiplex pair-ended methodology using the Illumina platform. Aiming to contribute to the therapeutic viability verification of bacteriophages we tested phage protective and therapeutic effects of Shfl1, Saen1v2 and Saen1v4, which belong to our collection, in biologically relevant models. Phage Shfl1, lytic against Shigella flexneri, was tested in a HeLa invasion assay. Intracellular bacteria reduction was measured independently through plating and flow cytometry, besides direct observation through fluorescent microscopy. Phage Saen1v2, lytic against Salmonella Typhimurium, was studied about its bio-distribution and half-life in murine model, and a viral variant with longer in vivo persistence was selected. This variant, denominated Saen1v2p5, and phage Saen1v4, lytic against Salmonella Typhi, were tested in murine typhoid model, against their respective hosts. Genomic similarity to known phages such as T4, T7, T1 among others, was found, in various degrees. We obtained both protective and therapeutic effect against Shigella flexneri using phage Shfl1 in the HeLa invasion assay, through all methodologies utilized. We could not verify in vivo antimicrobial effect of phage Saen1v2p5 in the murine model of Salmonella Typhimurium infection. On the other hand, we observed both therapeutic and protective dose dependent effect using phage Saen1v4 in Salmonella Typhi murine infection model. The success obtained with low multiplicities of infection may suggest a possible indirect effect or unspecific immune stimulation
Doutorado
Microbiologia
Doutor em Genetica e Biologia Molecular
Sooda, Anuradha. "Discovery of novel HLA-B*57:01 restricted T-cell antigens through genome-wide screening of Epstein-Barr virus." Thesis, Sooda, Anuradha (2020) Discovery of novel HLA-B*57:01 restricted T-cell antigens through genome-wide screening of Epstein-Barr virus. PhD thesis, Murdoch University, 2020. https://researchrepository.murdoch.edu.au/id/eprint/54110/.
Повний текст джерелаN'Guyen, Yohan. "Détection moléculaire des formes complètes et tronquées en région 5’non codante des Entérovirus et conséquences sur la réponse inflammatoire chez des patients souffrant de myocardite ou de cardiomyopathie dilatée Virus detection and semiquantitation in explanted heart tissues of idiopathic dilated cardiomyopathy adult patients by use of PCR coupled with mass spectrometry analysis Enterovirus but not Parvovirus B19 is associated with idiopathic dilated cardiomyopathy and endomyocardial CD3, CD68, or HLA-DR expression Major Persistent 5' Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues Enterovirus Persistence in Cardiac Cells of Patients With Idiopathic Dilated Cardiomyopathy Is Linked to 5' Terminal Genomic RNA-Deleted Viral Populations With Viral-Encoded Proteinase Activities." Thesis, Reims, 2019. http://www.theses.fr/2019REIMM203.
Повний текст джерелаMajor enterovirus (EV) populations characterized by 5’ terminal genomic RNA deletions (TD) ranging up to 50 nucleotides were previously identified in cardiac tissues from acute myocarditis and chronic dilated cardiomyopathy (DCM) patients. Dynamics of emergence and impact of various EV-TD populations onto the inflammatory response remains unknown. Using a PCR-MS approach EV-RNAs were detected alone (32%) or with PVB19 genomes in 48 % of patients with an idiopathic DCM. Among these patients, EV- RNA was associated with a positive endomyocardial CD3, CD68 ou HLA-DR immunostaining. In these EV-DCM cases, a quantitative "RACE-PCR" system showed that 37 to 50 nt EV-TD forms were the major persistant viral populations (80%) in association with 15 to 36 nt EV-TD (19%) and full-length (FL) (1%) forms. In samples from myocarditis cases, levels of 37 to 50 nt EVB-TD forms (84%) appeared to be statistically higher than other EV-TD (8%) and FL forms (8%) (P<10-3). Among severe myocarditis cases subgroup, levels of 15 to 36 nt EV-TD forms were significantly higher (P=0.02)) and associated with higher IFN-β mRNA levels (P=0.02)) than in non-severe myocarditis patients. HCM transfection of synthetic 8 to 36 nt EV-TD forms induced higher IFN-β mRNA (P<10-3) and cytokine levels (P=0.02) comparatively to those obtained after transfection by others deleted EV RNA forms. EV-RNA TD populations appeared to be major in acute myocarditis and DCM cases. Moreover, the proportions of minor 15 to 36nt EV-TD forms could modulate the innate immune sensing mechanisms in cardiomyocytes and therefore the clinical severity of cardiac infection
Odenbrink, Viktor, and Viktor Johansson. "Utveckla kassaflödet genom hela affärsprocessen : En fallstudie hos en hustillverkare." Thesis, Linnéuniversitetet, Institutionen för ekonomistyrning och logistik (ELO), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-66053.
Повний текст джерелаBackground: The housing market is an important part of society, where increased housing is a prerequisite for ensuring future housing. Unfortunately, population growth tends to increase at a faster pace compared to the number of homes being built. Furthermore, it is not always easy to justify a construction project as it extends over a long time, requires large capital and thus involves risks. Capital intensive projects therefore require thoughtfulness as it may tend to affect cash flow negatively. As studies are lacking in how the capital requirements and cash flow relate to the business process for construction companies and house manufacturers, we want to look closer with our business case. A stable cash flow is important for future survival and therefore also for future housing. Purpose: The purpose of this work is to map the business process of our business case and map the capital requirement throughout the business process. Furthermore, the purpose of this study is to provide on the basis of the survey, suggestions on how the company can control and streamline the cash flow through the business process. This study also aims to provide knowledge about how house manufacturers and construction companies can control and streamline their cash flows throughout the business process. Method: During this study, case study has been the basis of the research conducted as a method. The empirical basis has been obtained through unstructured and semi- structured interviews. Furthermore, observations and documents have also been part of the empirical basis.
Persson, Julia, Jenny Runnqvist, and Rebecca Waernulf. "Legitimitet i ideella elitidrottsföreningar Möjligheten att spegla hela verksamheten genom redovisningen." Thesis, Örebro universitet, Handelshögskolan vid Örebro Universitet, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56015.
Повний текст джерелаKallin, Eric Michael Zhang Yi. "Epigenetic regulation of gene transcription Jhdm1b characterization and genome-wide localization of H2A ubiquitylation /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2871.
Повний текст джерелаTitle from electronic title page (viewed Jun. 4, 2010). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum of Genetics and Molecular Biology." Discipline: Genetics and Molecular Biology; Department/School: Medicine.
Ali, Zhian. "Jag behöver språk som ett verktyg genom hela livet! : En kvalitativ studie om förskollärarnas arbetssätt med flerspråkiga barns språkutveckling genom modersmål." Thesis, Uppsala universitet, Institutionen för pedagogik, didaktik och utbildningsstudier, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412547.
Повний текст джерелаKronvall, Eva. ""Kränkningar går som i en cirkel hela tiden!" : Elever undersöker begreppet kränkningar i en fokusgrupp genom drama." Thesis, Högskolan i Gävle, Avdelningen för kultur-, religions- och utbildningsvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-14820.
Повний текст джерелаKyllergård, Olivia. "”Vi sopade hela dagen igår säger vi…" : En jämförande studie över barns sätt att kommunicera genom lek." Thesis, Högskolan i Borås, Akademin för bibliotek, information, pedagogik och IT, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-12326.
Повний текст джерелаHenrik, Strand, and Oskar Östlund. ""Vi säljer upplevelser" : En studie om hur motorcykelbranschen kan stärka sitt erbjudande över hela året genom en omnikanalstrategi." Thesis, Linnéuniversitetet, Institutionen för marknadsföring (MF), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-88149.
Повний текст джерелаAbstract Title “We sell experiences” - A study on how the motorcycle industry can strengthen its offering throughout the year through an omnichannel strategy Keyword Omni-Channel Strategy, Seasonal Sales, Experience Economi, Motorcycle Industry, Touchpoints, CEM, CRM Research Question In what ways can the motorcycle industry with seasonal sales use an omnichannel strategy to strengthen its brand and create offers throughout the year? Purpose The purpose of the study is to increase knowledge of how the MC industry can use an omnichannel strategy that helps motorcycle dealers strengthen their brand and increase sales and offers throughout the year regardless of season. Method The study has used a qualitative research strategy with an abductive approach. The study is based on relevant theory that created questions for seven semi-structured interviews with representatives of a quota selection. Conclusion In order for motorcycle dealers to strengthen their brand and create relevant offers throughout the year, an omnichannel strategy should be implemented. In this strategy, the company should prioritize customer service and create experiences as well as long-term and loyal customer relationships. Synchronize all channels for a seamless experience, create a brand experience and commitment throughout the year with creative offerings. Design service landscapes both traditional and virtual that contribute to brand experience, value creation and community.
Rundgren, Klara, and Elin Svensson. "Högläs skönlitteratur för att lära med hela kroppen : En aktionsforskningsstudie om att bearbeta högläsning genom drama i årskurs tre." Thesis, Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-28953.
Повний текст джерелаKlint, Axel, and Fabian Strand. "Utmaningar med implementering av BIM genom hela värdekedjan : en analys av informationsgap i BIM-projekt med stöd av innovationsteori." Thesis, KTH, Fastigheter och byggande, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-297636.
Повний текст джерелаDigitalization is constantly being discussed and has in recent years developed on many levels. Building information management, further described as BIM, has long been considered a digital solution in the construction and management industry. A solution that suitably would develop the industry in several areas. Despite this, digital development is relatively low which may indicate lower productivity than can be achieved. There is a lack of previous studies on why there is an information gap between stakeholders throughout the value chain that can partly explain low productivity and low effective stakeholder efficiency. The purpose of this study is thus to investigate the existing difficulties in the implementation of BIM in the entire value chain and what these difficulties lead to, such as information gaps between the design, construction and management side within a project. The findings of the study are explained with support of innovation theory and investment theory, with main focus on innovation theory. With support of the theories, difficulties with implementation of BIM for stakeholders and any information gaps that arise have been studied more deeply. This study conducted eight semi-structured interviews with real estate companies, architecture companies, one consulting company and one interest group. Existing challenges regarding implementation of BIM among different stakeholders, which may be the basis for impaired interoperability, can be explained in the absence of common industry standards, absence of a central BIM coordinator and generally low level of education about the subject BIM. It is noted that there is an information gap between stakeholders working on the administrative side versus design/construction and can be partly explained due to reluctance to adapt to new solutions according to innovation theory and partly due to the absence of common industry standards. The fact that the cost so far is not always less than the benefit of investing in BIM may explain why stakeholders in the project phase choose that BIM does not have to be appropriate to implement. The implementation phase through the value chain of a project varies a lot for different stakeholders and because of that the industry may in some cases be interpreted as conservative. This could be explained due to the language barriers that can arise when using different BIM systems and due to absence of open standards. To further develop understanding on the subject issue, studies need to be carried out on proprietary rights and problems in tender calculation estimates. Moreover, studies on public sector impact regarding development around common industry standards, external and internal BIM coordination linked to more effective project management and how common industry standards affect different stakeholders in the whole value chain of a project may develop understanding on the subject issue.
Bhrigu, Vipul. "Replication of Adeno-Associated Virus in Murine Fibroblasts with Mouse Adenovirus Provided Helper Functions." University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1242316433.
Повний текст джерелаKonstantinidis, Michalis. "Preimplantation genetic diagnosis : new methods for the detection of genetic abnormalities in human preimplantation embryos." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:28611f65-7729-4293-9c3f-4fc3f0cc39d7.
Повний текст джерелаJha, Rajesh. "Combined Computational-Experimental Design of High-Temperature, High-Intensity Permanent Magnetic Alloys with Minimal Addition of Rare-Earth Elements." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2621.
Повний текст джерелаFarrell, John J. "The prediction of HLA genotypes from next generation sequencing and genome scan data." Thesis, 2014. https://hdl.handle.net/2144/14694.
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