Дисертації з теми "GBM Patients"
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De, Gzell Cecelia Elizabeth. "OPTIMISING OUTCOMES IN PATIENTS WITH GLIOBLASTOMA RECEIVING RADIOTHERAPY." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16549.
Повний текст джерелаRANCATI, SILVIA. "A nanoformulated 11-miRNA pool synergistically modulates GBM cells invasion and in vivo growth." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1045591.
Повний текст джерелаPavliš, Jaroslav. "Přenos pacientských informací pomoci GSM." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217737.
Повний текст джерелаKober, Sylvia Deborah geb Pflederer [Verfasser]. "Parkinson’s disease patients with heterozygous GBA-mutation : longitudinal phenotyping of motor and non-motor symptoms – more rapid progression compared to Parkinson’s disease patients without GBA-mutation / Sylvia Deborah geb. Pflederer Kober." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1226756417/34.
Повний текст джерелаGalper, Jasmin. "Inflammatory and lipid markers in clinical and pre-clinical Parkinson’s disease patients." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27967.
Повний текст джерелаHurley, Samantha Jane. "The physico-chemical mechanisms underlying the physiological effects of non-starch polysaccharides: studies in ileostomy patients." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310783.
Повний текст джерелаRIBOLDI, GIULIETTA. "INTEGRATED GENOMIC ANALYSIS OF ISOLATED CD14+ MONOCYTES IN PATIENTS WITH GBA-RELATED PARKINSON¿S DISEASE." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/827744.
Повний текст джерелаKihlgren, Mona. "Integrity promoting care of demented patients." Doctoral thesis, Umeå universitet, Institutionen för omvårdnad, 1992. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100570.
Повний текст джерелаS. 1-61: sammanfattning, s. 63-184: 7 uppsatser
digitalisering@umu
江寶盈 and Po-ying Kong. "Relationship between self-reflection and insight in early psychosis patients using guided illness model questionnaire (GIM) / y Kong Po Ying, Cathy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/192950.
Повний текст джерелаpublished_or_final_version
Psychological Medicine
Master
Master of Psychological Medicine
Toupin, Amanda. "Analyse de biomarqueurs au niveau cellulaire de patients atteints de la maladie de Fabry en utilisant la spectrométrie de masse en tandem." Mémoire, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/11789.
Повний текст джерелаGabes, Michaela [Verfasser], and Christian [Akademischer Betreuer] Apfelbacher. "Patient-reported outcome measures beim Genitourinary Syndrome of Menopause (GSM): systematische Übersichtsarbeit, Validierung des „Day-to-Day Impact of Vaginal Aging (DIVA) Questionnaire“ und Exploration der urologischen Komponente des GSM / Michaela Gabes ; Betreuer: Christian Apfelbacher." Regensburg : Universitätsbibliothek Regensburg, 2021. http://d-nb.info/1233865579/34.
Повний текст джерелаRibeiro, Fernandes Hugo José. "Elucidating the role of GBA in the pathology of Parkinson's disease using patient derived dopaminergic neurons differentiated from induced pluripotent stem cells." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:7027574c-dda4-4752-9010-4c573bd0b2aa.
Повний текст джерелаSchröter, Nils [Verfasser], Nurcan [Gutachter] Üçeyler, and Christoph [Gutachter] Wanner. "Diagnostische Wertigkeit von Gb3-Ablagerungen in der Haut von Patienten mit M. Fabry / Nils Schröter ; Gutachter: Nurcan Üçeyler, Christoph Wanner." Würzburg : Universität Würzburg, 2018. http://d-nb.info/1156534097/34.
Повний текст джерелаKämpf, Tanja [Verfasser], and Frank [Akademischer Betreuer] Weidemann. "Definition eines klinisch relevanten Morbus Fabry mit Hilfe des Biomarkers Lyso Gb3 bei Patienten mit einer alpha- Galaktosidase Mutation / Tanja Kämpf. Betreuer: Frank Weidemann." Würzburg : Universitätsbibliothek der Universität Würzburg, 2013. http://d-nb.info/1034813331/34.
Повний текст джерелаHohmann, Friedrich Anton [Verfasser], Gerhard [Akademischer Betreuer] Krönke та Gerhard [Gutachter] Krönke. "Klinische Assoziationen von GBP-1, IFN-α und IFN-γ bei Patienten mit systemischem Lupus erythematodes / Friedrich Anton Hohmann ; Gutachter: Gerhard Krönke ; Betreuer: Gerhard Krönke". Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2021. http://d-nb.info/123889884X/34.
Повний текст джерелаVallerand, David. "Etude du stroma de tumeurs mammaires humaines xénogreffées et de modèles transgéniques murins." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T001.
Повний текст джерелаTumor development is a multi-step process influencing by interactions between tumor cells and surrounding stroma. Breast cancer development involves a high level of communication between mammary epithelial cells, inflammatory cells, myofibroblasts and endothelial cells. So, the tumoral microenvironment appears as a prime target for anti-tumoral treatment. The use of preclinical models is a critical step in development and validation processes of new therapies. Nevertheless, the role of stroma in these models is poorly understood.In order to evaluate stromal cell populations in breast cancer preclinical models, we combined flow cytometry analysis and immunohistochemistry to identify, and then quantify, various stromal populations as hematopoietic cells (lymphocytes, monocytes/macrophages, polymorphonuclear leukocytes) and non-hematopoietic cells (myofibroblasts, endothelial cells). Twenty-one breast cancer patient-derived xenografts as well as 2 transgenic mouse models (MMTV-PyMT and MMTV-ErbB2), and their respective allografts, were studied.Analysis of human and murine tumors showed a strong heterogeneity between tumors regarding infiltrating stroma-cells, with a high proportion of macrophages. A significant amount of polymorphonuclear leukocytes was also detected in PDXs, indicating a local inflammation in these models. The phenotypic analysis of macrophages showed a variable expression of M1 and M2 markers in PDXs. Macrophages infiltrating transgenic mouse tumors, spontaneous or allografted, were mainly M1. Transcriptomic analyses of sorted macrophages, allowed us to validate previous results but also highlighted major differences in the expression of numerous genes implicated in various pathways as tumor growth, invasion and metastasis.Finally, this study highlighted the impact of tumor cells on their surrounding stroma. Indeed, we demonstrate that cancer cells are able to attract a specific panel of stromal cells and activate them in a specific way
Skříčková, Alžběta. "Rehabilitační centrum Pasohlávky." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2019. http://www.nusl.cz/ntk/nusl-392069.
Повний текст джерелаAlnaami, Ibrahim. "Evaluation of Concomitant Temozolomide Treatment in Glioblastoma Multiforme Patients in Two Canadian Tertiary Care Centers." Master's thesis, 2010. http://hdl.handle.net/10048/1300.
Повний текст джерелаClinical epidemiology
Campos, Valenzuela Jaime Alberto. "Classification of Glioblastoma Multiforme Patients Based on an Integrative Multi-Layer Finite Mixture Model System." Doctoral thesis, 2016. https://tud.qucosa.de/id/qucosa%3A32248.
Повний текст джерелаLin, Jian-Yong, and 林建勇. "The correlation and prognostic significance of Foxp3 isoform expression in tumor infiltrating lymphocytes and glioma cells from GBM patients." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/53835870913705937345.
Повний текст джерела中國醫藥大學
免疫學研究所碩士班
100
As themost malignant high-grade glioma, prognosis for patients with glioblastoma multiforme (GBM) has only a median survival of 15 month, and 88% mortality within 3 years. Forkhead box protein 3 (Foxp3) is considered to be an important gene for thymically derived and naturally occurring regulatoryTcells (Tregs),whichregulate the immunosuppressive response. Recent studies described the expression of forkhead box P3 (Foxp3) in several tumor cells for providing the possibility of effector T-cell evasion. The present work was to investigate the significance of Foxp3 expression in glioblastoma multiforme (GBM) patients. FOXP3 largely controls the development into Treg cells, and three isoforms Foxp3, Foxp3-WT, FOXP3-△2 and FOXP3-△2△7, have been shown to be expressed in human Treg cells. FOXP3-WT represses NFAT- and NF?羠-mediated gene transcription process , while FOXP3-△2 is involved in repressing the transcriptional activity of the retinoic acid-related orphan receptors alpha (RORα) and gamma-t (RORγt) that regulates the development of antigen-stimulated naive CD4+ T cells into T-helper 17 (Th17) cells . FOXP3-△2△7 has been identified to negatively regulate the function of FOXP3-WT, and FOXP3-△2. We isolated Tregs from infiltrating lymphocytes (TILs) of GBM by FACS analysis. Then, we analyzed the expression of key molecules of Treg function in lymphocytes and tumor cells and correlate with the DC-therapy response of the corresponding patient. Both Tregs and tumor cells express 3 different isoforms of the FOXP3 gene by alternative splicing, one of which represents a naturally occurring dominant negative version of the Foxp3 protein.The proportion of Tregs in CD4+ TILs had been observed the increasing percentage in GBM patients with short survival. However, there was no significant difference in three isoforms of Foxp3 expressed in Tregs comparing with survival of GBM patients. But, three patients with high survival (over 2 years) had shown the expression of dominant negative FOXP3-△2△7 isoform.The differential expression level of Foxp3 isoforms may constitute a potent prognosis factor for GBM patients. Tregs may limit DC-therapy against GBM, while the differential expression of Foxp3 isoforms could provide a basis for the evaluation of the effectiveness of DC-therapy. Functional abrogation of Foxp3 by tuning the splicing preference to its dominant negative isoform may offer an attractive window to inhibit Treg activity.
Pal, Jagriti. "Elucidating Deregulated Novel Pathways in Glioma through Genetic and Epigenetic Approaches." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/4284.
Повний текст джерелаChang, Chung-Ching, and 張仲晴. "Optimization of Boron Neutron Capture Therapy Treatment Planning System NCTPlan for Patient with GBM." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/74299018315923066315.
Повний текст джерелаMurphy, Danielle Marie. "Effect of chewing gum on the incidence of plaque accumulation and gingival inflammation in adolescent orthodontic patients a thesis submitted in partial fulfillment ... for the degree of Master of Science (School of Dentistry) ... /." 2002. http://catalog.hathitrust.org/api/volumes/oclc/68962491.html.
Повний текст джерелаSchröter, Nils. "Diagnostische Wertigkeit von Gb3-Ablagerungen in der Haut von Patienten mit M. Fabry." Doctoral thesis, 2018. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-160552.
Повний текст джерелаFabry disease (FD) is an X-chromosomally linked disease which leads to deposits of globotriaosylceramide 3 (Gb3) in several tissues. The aim of this study was to prove, that these deposits can be shown in the skin of patients with FD via immunofluorescence, that Gb3 deposits can be quantified, that patients with FD have more Gb3-deposits in their skin than healthy controls and that the amount of Gb3 deposits in skin correlates with disease severity. 84 patients were prospectively recruited in the Würzburg Fabry Center for Interdisciplinary Therapy as well as 27 healthy controls. Every patient received a skin biopsy from a proximal and a distal location, a physical examination as well as a thorough anamnesis, filled out questionnaires regarding pain and symptoms hinting for depression and underwent cardiac diagnostics. Immunofluorescence double stains were done for Gb3 and protein-gene-product 9.5 as well as for Gb3 and von Willebrand factor. We quantified the amount of Gb3 semi-automatically in three predetermined regions of interest. We could show, that Gb3 can be visualized and quantified in the skin of patients with FD using immunofluorescence. Furthermore, male patients with FD had a higher Gb3 load in their distal skin than healthy controls (p<0.05). Male patients with FD and an impaired renal function had a higher Gb3 load in their distal skin (p<0.05). Similarly, it was shown, that male patients with a small fiber neuropathy had a higher load of Gb3 in their distal skin than male patients without a small-fiber neuropathy (p<0.05). In conclusion it can be stated, that the quantification of Gb3 via immunofluorescence could be used in the diagnostics of FD and might be of value as a biomarker in the course of the disease
Raj, Preethi. "The Impact of Gestational Diabetes on Maternal and Cord Blood Lipids Among Prenatal Care Patients in Western Ma." 2012. https://scholarworks.umass.edu/theses/941.
Повний текст джерелаAlão, Mariana Neves Ramalho Ferreira. "Deep and transfer learning approaches for glioblastoma patient survival prediction from pre-treatment MRI." Master's thesis, 2019. http://hdl.handle.net/1822/70817.
Повний текст джерелаGlioblastoma Multiforme (GBM) is a harmful brain tumor with a median overall survival (OS) of only fourteen months. Predicting the OS from pre-treatment Magnetic Resonance Imaging (MRI) is intrinsically tricky not only due to the morphologic characteristics of the tumor but also due to the impact of the treatment. In the last years, deep learning began to arouse the interest of the scientific community due to the excellent performances achieved. In the medical imaging field, the convolutional neural networks (CNN) are achieving better performances than the clinicians in several tasks. This dissertation aims to develop a deep learning model for regression to directly predict the OS using pre-treatment MRI scans from patients with glioblastoma. For this, three different approaches were used: the transference of knowledge from a 2D and a 3D CNN and training from scratch on a 3D CNN. The effects of inputting different MRI modalities with different preprocessing techniques, such as the region of interest (ROI) and z-score normalizations, were studied. After a first selection of the top-ranked models based on two distinct criteria, data augmentation was performed. Throughout this work, the approaches were analyzed individually and then compared with each other and with a state-of-the-art approach. Although it was not possible to conclude on the MRI modalities and z-score normalization that benefits the most the OS prediction, a preference for a broader context while training the model was evident. The importance maps from the 3D networks developed showed that the regions considered most important by the network overlap with the ones where the tumor is more frequent. The network with more potential for the OS prediction is the 3D CNN trained from scratch that used FLAIR and tumor segmentation as input, ROI as all image and z-score normalization to all the image. In the end, this model was not able to outperform the state of the art.
O Glioblastoma Multiforme é um tumor cerebral nocivo com uma sobrevida mediana de apenas catorze semanas. Prever o tempo de sobrevida a partir de imagens de ressonância magnética é intrinsecamente difícil, não apenas devido às características morfológicas, mas também devido ao impacto dos tratamentos. Durante os últimos anos, o deep learning começou a despertar o interesse da comunidade científica devido às excelentes performances obtidas. Na área da imagem médica, as redes neuronais convolucionais estão a obter melhores performances que os médicos em diversas tarefas. Esta dissertação tem como objetivo desenvolver um modelo de regressão de deep learning para prever o tempo de sobrevida através de ressonâncias magnéticas pré-tratamento de pacientes com glioblastoma. Para tal, três diferentes abordagens foram utilizadas: a transferência de conhecimento de uma rede neuronal convolucional 2D e de outra 3D e ainda treinar do zero uma rede neuronal convolucional 3D. Os efeitos de introduzir na rede diferentes modalidade de ressonância magnética com diferentes préprocessamentos, tal como a região de interesse considerada ou a normalização padrão efetuada, foram estudados. Após uma primeira seleção dos modelos com melhores métricas baseada em dois critérios distintos foi efetuado o aumento artificial dos dados. Durante este trabalho, as diferentes abordagens foram analisadas individualmente e posteriormente comparadas entre si e com o estado da arte. Embora não seja possível concluir sobre modalidade de ressonância magnética e o tipo de normalização padrão que beneficiam a previsão do tempo de sobrevida, e preferência por um contexto visual mais abrangente foi evidente. Os mapas de importância relativos às redes neuronais 3D mostram que as regiões consideradas mais importantes pela rede coincidem com as que o tumor é mais frequente. A rede que revelou um maior potencial para prever o tempo de sobrevida é a rede neuronal convolutional 3D treinada do zero que utiliza a sequência FLAIR conjugada com a segmentação do tumor como entrada da rede, a região de interesse é toda a imagem e a normalização padrão é efetuada a toda a sequência. Por fim, este modelo não foi capaz de ultrapassar o estado da arte.
Kämpf, Tanja. "Definition eines klinisch relevanten Morbus Fabry mit Hilfe des Biomarkers Lyso Gb3 bei Patienten mit einer alpha- Galaktosidase Mutation." Doctoral thesis, 2013. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-77819.
Повний текст джерелаFabry disease is a lysosomal storage disorder caused by mutations in the alpha-galactosidase A gene. This leads to a deficiency of alpha-galactosidase A. Therefore globotriaosylceramide accumulate in all tissues containing lysosomes. There is the classical phenotyp and the atypical one. No method to differentiate these variants is available so far. Our study includes 124 Fabry patients. Detailed clinical investigations of the heart, kidneys and the nervous system were made. Apart from that the biomarker lyso-Gb3 was measured in every patient. The study consists of two parts: Part one (evaluation) includes all previously described mutations and part two (validation) all unknown mutations. We could show that the disease-capacity of a mutation can be analyzed by lyso Gb3 and that it is possible to differentiate a classical from an atypical mutation by the biomarker lyso Gb3