Дисертації з теми "Gastroschisi"
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Kruscha, Josefine. "Analyse verschiedener Risikofaktoren und Prävalenzentwicklung der Gastroschisis im Zeitraum 2003 bis 2010 in Leipzig." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-178871.
Повний текст джерелаMüller, Marc. "Fetalchirurgischer Verschluss der Gastroschisis im Kaninchenmodell." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-97498.
Повний текст джерелаRimaz, Shahnaz. "Epidemiology of omphalocele and gastroschisis in Glasgow." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340758.
Повний текст джерелаAbbate, Tina. "Gastroschisis in New York State, 1998-2010." Thesis, State University of New York at Binghamton, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3728176.
Повний текст джерелаIn the United States, one out of every thirty-three infants is born with some sort of birth defect or congenital malformation. Certain risk factors such as age and substance use increase the likelihood of having a baby afflicted with a defect and public health nurses have worked tirelessly to educate the public about these factors. In addition, thanks to modern medicine, many defects are detected early in pregnancy, which allows for careful monitoring and planning for the delivery. In spite of these gains, birth defects continue to dominate the public health arena because they are a leading cause of death for infants and play a prominent role in long-term morbidity and disability.
Gastroschisis and omphalocele are abdominal wall defects that present with herniation of intestines and organs due to failure of abdominal wall closure during embryonic development. Of the two abdominal wall defects, gastroschisis has demonstrated a worldwide increase in prevalence over the last three to four decades. The common denominator in the literature is young maternal age. However, the relationship between maternal age and gastroschisis is unclear. This study utilized birth certificate data from New York State to examine the relationship between maternal characteristics and delivering an infant with gastroschisis.
In this study, the infants diagnosed with gastroschisis were mostly singleton births born at an earlier gestation (34-36 weeks) and a lower birth weight (1500-2499 gm) than infants without gastroschisis. From a demographic perspective, mothers of infants with gastroschisis were more likely to be younger (≤24), Hispanic or less educated. The findings also revealed that mothers of infants with gastroschisis were more likely to have inadequate prenatal care, use tobacco, illicit drugs or have a sexually transmitted disease. Mothers of infants with gastroschisis were also more likely to live in a non-metropolitan county or fall into a lower socioeconomic status. Further research is needed to continue examining the relationship between maternal characteristics and a diagnosis of gastroschisis in the newborn infant.
Grossberndt, Sonja. "Aspekte der Fehlbildungsprävention am Beispiel der Gastroschisis." [Magdeburg] Blauer-Punkt-Verl, 2007. http://d-nb.info/991225937/04.
Повний текст джерелаYazdy, Mahsa Mirmiran. "Environmental and infectious risk factors for gastroschisis." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12946.
Повний текст джерелаGastroschisis is a rare congenital malformation where loops of bowel are protruding from the abdominal wall of an infant. The prevalence of gastroschisis has been increasing over the past 20 years, particularly in younger women. However, as the number of studies on gastroschisis increases each year, it continues to remain unclear why the prevalence is increasing and why it disproportionately affects younger mothers. Previous research has suggested that environmental or infectious factors may be involved in the pathogenesis of gastroschisis. This dissertation aims to explore the possibility of these two factors in relation to gastroschisis. In study 1, clusters of gastroschisis were identified in space or the combination of space and time. Cases and controls came from the National Birth Defects Study (NBDPS) or for some study centers from the birth defects surveillance systems. Generalized additive models were used to create a continuous map surface of odds ratios (OR) by smoothing over latitude and longitude. Data from the NBDPS were used for the Arkansas, California, and Utah study centers and the highest adjusted ORs detected were 2.0, 1.3, and 2.4, respectively. In Massachusetts and Texas, where surveillance data were used, the highest adjusted ORs observed were 2.4 and 1.3, respectively, with only the latter state achieving statistical significance. Texas had sufficient data to assess the combination of space and time, which identified an increased risk (OR=2.9) in the center of Texas in 2003. The results of this study suggest that clusters of gastroschisis may exist and further exploration of environmental or behavioral factors are warranted. [TRUNCATED]
Trost, Stefanie. "Retrospektive Analyse des kurzfristigen Outcomes von Patienten mit Gastroschisis und Omphalocele am Zentrum für Kinder- und Jugendmedizin Leipzig." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-83329.
Повний текст джерелаDraper, Elizabeth Sharon. "Recreational drug use : a major risk factor for gastroschisis?" Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/30482.
Повний текст джерелаBremer, Sophia Alice. "Prävalenz von Gastroschisis, Omphalozele, Spina bifida und orofazialen Spaltbildungen bei Neugeborenen im Zeitraum Januar 2000 bis Dezember 2010 in Leipzig, Sachsen, Sachsen-Anhalt und Deutschland." Doctoral thesis, Universitätsbibliothek Leipzig, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-219767.
Повний текст джерелаLipinski, Agnes Sylvie [Verfasser]. "Retrospektive Analyse des Outcome von Kindern mit intestinalen Begleitfehlbildungen bei Gastroschisis / Agnes Sylvie Lipinski." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/102326269X/34.
Повний текст джерелаD'Souza, Anita Christine [Verfasser], and Klaus-Dieter [Akademischer Betreuer] Rückauer. "Gastroschisis und Omphalozele - Somatische Ergebnisse der operierten Kinder und psychische Verarbeitung durch die Eltern." Freiburg : Universität, 2013. http://d-nb.info/1123476780/34.
Повний текст джерелаFrança, Willy Marcus Gomes. "Avaliação histologica e imunohistoquimica da maturidade dos plexos mioentericos na gastrosquise experimental de ratos realizada em duas diferentes idades gestacionais." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310461.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: Na gastrosquise (G), o grau de lesão das alças intestinais exteriorizadas está diretamente relacionado ao tempo de contato com o líquido amniótico (LA) e exposição ao mecônio, que causam alterações morfológicas e histológicas do intestino, além da formação de uma fina camada de fibrina (fibrous peel) sobre a serosa, formando aderências entre as alças intestinais. Estas lesões levam ao hipoperistaltismo intestinal e deficiência na absorção dos nutrientes, contribuindo para o aumento da morbidade e alto custo médico-hospitalar. O hipoperistatismo na G é atribuído à desorganização e à imaturidade dos plexos mioentéricos. Estas características podem servir como marcadores do grau de lesão intestinal, e que podem ser identificados pela presença de neurofilamentos dos plexos nervosos intestinais e sugerir a antecipação do parto. Nesse estudo identificamos as alterações morfológicas e histológicas intestinais e dos plexos mioentéricos em dois diferentes tempos de contato com o LA. A G experimental em fetos de ratas Spreague-Dowley foi realizada em duas idades gestacionais, 18,5o dia (E18,5) e 19,5o dia (E19,5), que foram divididos em 3 subgrupos: controle (C), sham (S) e gastrosquise (G). Medimos o peso corporal fetal (PC), peso (PI) e comprimento intestinais (CI). As camadas da parede intestinal e os plexos mioentéricos foram avaliados pela coloração de H&E e imunofluorescência (?-Internexina), respectivamente. O PC não apresentou diferença significativa entre C/S/G, nos 2 grupos. O PI e CI foram respectivamente maior e menor nos fetos G (p<0,001) nos 2 grupos. Os diâmetros intestinais e as camadas da parede apresentaram diferença significativa entre C/S/G, em ambos os grupos (p<0,001), mas o tempo de contato com LA e exposição ao mecônio comprometeram a serosa e D-II (diâmetro II) (p<0,001), e CI (p=0,001). A ?-internexina apresentou imunorreatividade mais intensa nos fetos G de E18,5. Concluímos que no modelo de G em fetos de ratos, as alterações da parede intestinal, principalmente da camada serosa e do comprimento intestinal, bem como a imaturidade dos plexos mioentéricos, apresentaram-se mais intensas nos fetos cujo contato com o LA e exposição ao mecônio foram mais prolongados (G/E18,5). Estudos experimentais adicionais devem ser desenvolvidos e direcionados para compreensão da motilidade intestinal na G com o objetivo de minimizar os danos neuromusculares nas alças intestinais expostas ao LA e permitir avaliar as supostas vantagens da antecipação do parto para fetos humanos com G
Abstract: BACKGROUND: The amniotic fluid (AF) and its components such as fetal urine and meconium may lead to intestinal alterations in gastroschisis (G), which cause immaturity of the myenteric plexus and consequent intestinal hypomotility and malabsorption. In this study we identified morphological and histological alterations of the intestine and of the myenteric plexus with two different times of exposure to the AF. METHODS: The experimental G was achieved at two different gestational ages, on day 18.5 (E18.5) and on day 19.5 (E19.5) of gestation in fetal rats which were divided into 3 subgroups: control (C), sham (S) e gastroschisis (G). We measured fetal body weight (BW), intestinal weight (IW) and intestinal length (IL). The layers of intestinal wall and myenteric plexus were evaluated by hematoxylin and eosin staining (H&E staining) and immunofluorescence (?-Internexin), respectively. RESULTS: BW did not show significant differences among C/S/G, in both groups. IW and IL were respectively larger and shorter in the G fetuses (p<0.001) in both groups. Intestinal diameters and wall layers presented significant differences among C/S/G in both groups (p<0.001), but time of exposure to AF compromised the serous membrane, D-II (diameter II) (p<0.001) and IL (p=0.001). The ?-Internexin presented more intensive immunoreactivity in G/E18.5 fetuses. CONCLUSION: In gastroschisis, the longer the time of exposure to AF, the more severe will be bowel impairment, especially concerning IL and the serous layer; and the more immature will be the myenteric plexus
Doutorado
Cirurgia
Doutor em Cirurgia
Bennini, Junior João Renato 1978. "Gastrosquise = ultrassonografia na estimativa do peso fetal e predição de desfechos perinatais = Gastroschisis: ultrasonography for fetal weight estimation and prediction of perinatal outcomes." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312556.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Introdução: A literatura é controversa sobre o papel de parâmetros ultrassonográficos pré-natais na predição do risco de morbidade e mortalidade perinatais nos casos de gastrosquise. O peso ao nascimento é descrito como um importante fator prognóstico e estudos relatam que fórmulas ultrassonográficas criadas especificamente para esses casos apresentam melhor desempenho na estimativa do peso fetal, mas não há consenso sobre qual a melhor. Objetivos: Avaliar o papel de parâmetros ultrassonográficos pré-natais na predição de desfechos perinatais em casos de gastrosquise. Criar uma nova fórmula ultrassonográfica para estimativa de peso fetal que não utilize medidas abdominais e compará-la à outras fórmulas com parâmetros ultrassonográficos bidimensionais (US2D) e tridimensionais (US3D) quando aplicadas em fetos com gastrosquise. Métodos: Para avaliar o desempenho de parâmetros ultrassonográficos pré-natais na predição de desfechos perinatais foi realizado um estudo de coorte retrospectiva envolvendo fetos com o diagnóstico de gastrosquise isolada. Para criar e validar a nova fórmula US2D foram utilizados dados referentes à gestantes e fetos normais coletados em um estudo prévio publicado pelo nosso grupo. Foi realizado um estudo retrospectivo transversal envolvendo fetos com gastrosquise, para comparar a nova fórmula US2D com diferentes fórmulas US2D e US3D já publicadas. Os sujeitos foram selecionados entre aqueles acompanhados na Divisão de Obstetrícia do CAISM / UNICAMP. O tamanho da amostra foi estimado em 56 pacientes para avaliar o desempenho de parâmetros ultrassonográficos pré-natais na predição de desfechos perinatais e 27 pacientes para comparar as fórmulas de estimativa de peso fetal. Os dados maternos, gestacionais e pós-natais foram descritos como freqüências relativas e absolutas, média ± desvio padrão (DP), mediana e limites. A normalidade dos dados contínuos foi testada utilizando-se o teste de Kolmogorov¿Smirnov. Testes t de amostras independentes e testes de qui-quadrado foram utilizados na comparação de dados contínuos e categóricos, respectivamente. Análises de regressão polinominal até o terceiro grau foram consideradas para criar a nova fórmula US2D de estimativa do peso fetal sem medidas abdominais. Cálculo do erro percentual médio ± DP, testes t unilaterais, testes t de amostras pareadas com correção de Bonferroni e testes de variância para amostras pareadas foram usados para avaliar e comparar a acurácia e precisão das fórmulas. A associação entre dados contínuos foi testada utilizando-se os coeficientes de correlação de Pearson ou Spearman e regressão logística univariada, conforme indicado. Valores de p < 0,05 foram considerados significativos. Resultados: Foram incluídos 44 casos de fetos com gastrosquise para avaliar a predição de desfechos perinatais por meio de parâmetros ultrassonográficos pré-natais. A presença de dilatação de alças intestinais intra-abdominais (DAI) fetais aumentou o risco de complicacões intestinais pós-natais e a presença de restrição de crescimento fetal (RCF) diminuiu o risco deste mesmo desfecho. Nenhum outro parâmetro ultrassonográfico pré-natal pode significativamente predizer os desfechos perinatais avaliados. Foram usados os dados referentes aos mesmos grupos de 150 fetos normais e 60 fetos normais do estudo prévio para respectivamente criar e validar a nova fórmula US2D, que foi a seguinte: peso fetal estimado (PFE) = 623.324 + 0.165 x DBP x CC x CF2 (DP: 12,25%). Na comparação entre as fórmulas US2D e entre as fórmulas US2D e US3D, foram utilizados 44 e 28 fetos com gastrosquise isolada, respectivamente. O melhor desempenho na estimativa do peso de fetos com gastrosquise foi obtido com o modelo US2D proposto por Siemer e colaboradores. Conclusões: Em fetos com gastrosquise o achado de DAI múltipla associa-se a complicações intestinais pós-natais e a presença de RCF possui um efeito protetor para este mesmo desfecho. A nova fórmula US2D sem medidas abdominais não melhorou a estimativa do peso ao nascimento dos fetos com gastrosquise da nossa população em relação às outras fórmulas US2D e US3D avaliadas. Na nossa amostra de pacientes com gastrosquise o modelo S2D de Siemer e colaboradores apresentou o melhor desempenho na estimativa de peso
Abstract: Background: The role of prenatal ultrasonographic parameters for the predicition of perinatal outcomes in fetuses with gastroschisis is still controversial. Birthweight is described as a prognostic factor and some studies report that ultrasonographic formulas especifically created for these cases have a better performance for fetal weight estimation, but there is no consensus about which is the best one. Objectives: To evaluate prenatal ultrasonographic parameters as predictors of adverse perinatal outcomes in fetuses with gastroschisis. To create a new birthweight predicting ultrasonographic model without abdominal measurements and compare this new formula with other two-dimensional (2DUS) and three-dimensional (3DUS) fetalweight predicting models already published when aplied to fetuses with gastroschisis. Methods: To evaluate the performance of prenatal ultrasonographic parameters as predictors of perinatal outcomes in fetuses with gastroschisis a retrospective cohort study was done. To create and validate the new 2DUS formula the same data from normal fetuses colected in a previous study of our group was used. A retrospective cross-sectional study encompassing fetuses with gastroschisis was carried out to compare the new 2DUS formula with other 2DUS and 3DUS formulas already published. The patients were selected among those followed at the Division of Obstetrics of the Center for Integral Assistance to Women¿s Health of the State University of Campinas (UNICAMP). The sample size was estimated in 56 patients to evaluate prenatal ultrasonographic predictors and perinatal outcomes and 27 patients to compare the fetal weigth estimating formulas. Maternal, pregnancy and postnatal data were described as absolute and percentual frequencies, mean ± standard deviation (SD), median and range. Continuous data were tested for their normal distribution using the Kolmogorov¿Smirnov test. Independent samples t tests and chi-square tests were used in the assessment of continuous and categorical variables, when appropriate. Polynomial stepwise regression analyses up to the third order were considered to generate a new 2DUS weight-predicting model without abdominal measurements. Calculation of the mean percentage error ± SD, one-sample t tests, paired samples t-tests with Bonferroni adjustment and correlated variance tests for paired samples were used to compare the performances of the formulas. The potential association between continuous data was tested by means of Pearson or Spearman¿s Correlation Coefficient and univariate logistic regression, as indicated. A two-tailed p-value of less than 0.05 was considered statistically significant. Results: Forty-four fetuses were included to evaluate the ultrasonographic prental parameters as predictors of perinatal outcomes. The presence of fetal multiple intra-abdominal bowel dilation (IBD) was associated with increased incidence of intestinal complications and the presence of fetal growth restriction (FGR) had a protective effect over this outcome. No other prenatal ultrasographic parameter could significantly predict the perinatal outcomes evaluated. It was used the same data from our previous study on 150 normal fetuses and 60 normal fetuses to respectively generate and validate the new 2DUS formula, that was: estimated fetal weight = 623.324 + 0.165 x BPD x HC x FDL2 (SD: 12.25). In the comparison between the 2DUS formulas and between the 2DUS and 3DUS formulas it was included 44 and 28 fetuses, respectively. The best performance for weight prediction in fetuses with gastroschisis was achieved using the model created by Siemer et al. Conclusions: In fetuses with gastroschisis the findings of multiple IBD increases the risk of postnatal bowel complications and the presence of FGR decreases the risk of this outcome. The new 2DUS formula without abdominal measurements did not improve fetal weight estimation in fetuses with gastroschisis of our population when compared to other 2DUS and 3DUS formulas evaluated. The 2DUS weight estimating model of Siemer et al had the best performance for this purpose
Doutorado
Saúde Materna e Perinatal
Doutor em Ciências da Saúde
Root, Elisabeth Dowling Emch Michael. "The ecology of birth defects socio-economic and environmental determinants of gastroschisis in North Carolina /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2187.
Повний текст джерелаTitle from electronic title page (viewed Jun. 26, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Geography." Discipline: Geography; Department/School: Geography.
Abrar, Maria [Verfasser], Peter [Gutachter] Kozlowski, and Thomas [Gutachter] Höhn. "Pränatale prädiktive Faktoren im Ultraschall bei Feten mit Gastroschisis / Maria Abrar. Gutachter: Peter Kozlowski ; Thomas Höhn." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1103656759/34.
Повний текст джерелаRieg, Teresa Ines [Verfasser]. "Kurz- und langfristiges Outcome von Kindern mit Gastroschisis und Omphalozele im Vergleich im Zeitraum von 2000 bis 2011 / Teresa Ines Rieg." Ulm : Universität Ulm. Medizinische Fakultät, 2014. http://d-nb.info/1049238435/34.
Повний текст джерелаPunzmann, Sabine [Verfasser], and Bertram [Akademischer Betreuer] Reingruber. "Omphalozele und Gastroschisis - Analyse des Regensburger Patientengutes 1983 - 2007 unter Berücksichtigung der kosmetischen und funktionellen Langzeitergebnisse / Sabine Punzmann. Betreuer: Bertram Reingruber." Regensburg : Universitätsbibliothek Regensburg, 2011. http://d-nb.info/1023361906/34.
Повний текст джерелаCoelho, Amanda Santos Fernandes. "Alterações neonatais e maternas relacionadas ao óbito infantil em crianças com gastrosquise." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/4964.
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Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG
Infant mortality is an important indicator of a country’s health. It is observed in several regions of the world a proportion of deaths attributable to congenital malformations. Worldwide, it is estimated that prevalence occurs in 9% of live births. Among the major abnormalities is gastroschisis, that is a congenital malformation in which there is an exteriorization of the viscera through the abdominal wall defect to the right of the umbilical cord, which is implanted in its normal position. The objective of this study was analyze the neonatal and maternal changes related to infant mortality in children with gastroschisis. This is a cross-sectional and retrospective study with a quantitative approach. It used for analysis, secondary data collected from medical records of patients treated at a public hospital in Goiânia-GO, from 2004 to 2014. The study included 123 patients diagnosed with gastroschisis, which met the criteria adopted. In relation to maternal variables, 57.7% of the women were younger than 20 years, 64.2% were first pregnancy, cesarean birth occurred in 65% of cases, there was an average of 4.8 ± 2.5 prenatal consultation. In relation to neonatal variables, 59% of the new born with gastroschisis were male. The gestational age at birth of the 123 pregnancies ranged from 29.4 to 40.4 weeks (average = 36.5 ± 1.8 weeks). The weight of the new born ranged from 890g to 3800g (average = 2351 ± 474,2g), the average of the Apgar index in the first minute was 6.6 ± 1.8. Associated malformations (not intestinal) were found in 10 (8.1%) patients and 17 (13.8%) patients had intestinal abnormalities, and at this last the most common was the intestinal atresia. By observing the eviscerated organs, 70.7% of patients had only exposed intestinal loops and about other herniated organs, the stomach has been externalized in 27.6% of cases. The general mortality rate was 41% of cases. Statistically significant association was observed between the occurrence of death and mothers who performed less monitoring in prenatal care (p = 0.027) and when there was no diagnosis of gastroschisis in prenatal care (p = 0.001). It was also observed statistically significant association between the occurrence of death and the presence of complex gastroschisis (p = 0.032) and herniation of other organs beyond just the intestine (p = 0.018). It is concluded that, in relation to maternal and neonatal profile of gastroschisis, the condition has no gender preference, particularly affecting children of young first-time mothers. Perinatal mortality of gastroschisis in this analysis seems to depend mainly on the reduced prenatal care, the absence of prior diagnosis at birth, the presence of complex gastroschisis and herniation of other organs than just the intestine.
A mortalidade infantil é um importante indicador de saúde de um país, observa-se em várias regiões do mundo, uma proporção de mortes atribuíveis às malformações congênitas. Mundialmente, estima-se que a prevalência ocorre em 9% dos nascidos vivos. Dentre as malformações graves está a gastrosquise que, é uma malformação congênita em que há exteriorização das vísceras através de defeito na parede abdominal à direita do cordão umbilical, que é implantado em sua posição habitual. O objetivo deste trabalho foi analisar as alterações neonatais e maternas relacionadas ao óbito infantil em crianças com gastrosquise. Trata-se de um estudo transversal, retrospectivo e com abordagem quantitativa. Utilizou para tanto, dados secundários coletados dos prontuários de pacientes atendidos em um Hospital Público em Goiânia-GO, no período de 2004 a 2014. Foram incluídos 123 pacientes diagnosticados com gastrosquise, os quais preencheram os critérios adotados. Em relação às variáveis maternas, 57,7% das mulheres apresentaram idade menor que 20 anos, 64,2% eram primigestas, o parto cesariano ocorreu em 65% dos casos, houve uma média de 4,8 ± 2,5 consultas de pré-natal. Em relação às variáveis neonatais, 59% dos RN com gastrosquise eram do sexo masculino, a idade gestacional ao nascimento das 123 gestações variou de 29,4 a 40,4 semanas (média = 36,5±1,8 semanas), O peso do RN variou de 890g a 3800g (média = 2351±474,2g), a média do índice de Apgar no primeiro minuto foi de 6,6±1,8. As malformações associadas (não intestinais) foram encontradas em 10 (8,1%) pacientes e 17 (13,8%) pacientes apresentaram anomalias intestinais, sendo que nesta última a mais comum foi a atresia intestinal. Ao observar os órgãos eviscerados, 70,7% dos pacientes apresentavam somente alças intestinais expostas e quanto aos outros órgãos herniados, o estômago esteve exteriorizado em 27,6% dos casos. A taxa geral de mortalidade foi de 41% dos casos. Foi observada associação estatisticamente significativa entre a ocorrência de óbito e mães que realizaram menor acompanhamento no pré-natal (p= 0,027) e quando não houve diagnóstico da gastrosquise no pré-natal (p= 0,001). Foi ainda observada associação estatisticamente significativa entre a ocorrência de óbito e a presença de gastrosquise complexa (p= 0,032) e herniação de outros órgãos que não apenas o intestino (p= 0,018). Conclui-se que em relação ao perfil materno e neonatal da gastrosquise, observa-se que a afecção não possui predileção por sexo, acometendo particularmente filhos de jovens mães primíparas. A mortalidade perinatal da gastrosquise neste trabalho, parece depender principalmente do acompanhamento pré-natal reduzido, da ausência de diagnóstico prévio ao nascimento, da presença de gastrosquise complexa e da herniação de outros órgãos que não apenas o intestino.
Reiß, Anne-Kathrin [Verfasser], and Matthias W. [Akademischer Betreuer] Beckmann. "Wertigkeit der Ultraschallparameter und der B-Bildanalyse des fetalen Darms beim Management der fetalen Gastroschisis / Anne-Kathrin Reiß. Gutachter: Matthias W. Beckmann." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2013. http://d-nb.info/1065380631/34.
Повний текст джерелаBranco, Lívia Terezinha Pimentel. "Investigação farmacológica de mecanismos neurogênicos e oxidativos no modelo experimental de gastrosquise em ratos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-17112008-102233/.
Повний текст джерелаGastroschisis (G) is a congenital defect of the abdominal wall closure resulting in perivisceritis. The role of neurovascular and oxidative mechanisms in this condition was investigated by analyzing the gene and proteic expressions of these markers in the gut of foetus from female rats treated or not with dexamethasone (DMT). Increased MPO activity was found in G vs. control (C) but not sham (S) group. Reduced mRNA expression of NK2 receptor was found in G and S groups. Neither NK1 nor both VIP and TRPV1 receptors expression changed among groups. Increased expression of iNOS and COX-2, but not nNOS, eNOS and COX-1, was seen in G group. DMT reversed the expression of NK2R and increased that of NK1R without affecting iNOS and COX-2 expression. Increased levels of IL-6 but neither SOD-1 nor 3-NT was found in G group. In conclusion, the inflammatory process observed in the gut of foetus with G arises through a combination of neurogenic mechanisms that act in concert with reactive oxygen species and generation of prostanoids to produce gut dysfunction.
Treiber, Birgit [Verfasser], and Bertram [Akademischer Betreuer] Reingruber. "Der Einfluss eines optimalen peripartalen Managements auf die Mortalität, Lebensqualität und gastrointestinale Funktion bei Patienten mit Gastroschisis und Omphalozele / Birgit Treiber. Betreuer: Bertram Reingruber." Regensburg : Universitätsbibliothek Regensburg, 2016. http://d-nb.info/1081543361/34.
Повний текст джерелаLong, Anna-May. "Short and long-term outcomes of children born with abdominal wall defects." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:8f57a562-ca60-48b1-ba4f-356e65ee5bed.
Повний текст джерелаKruscha, Josefine [Verfasser], Eva [Akademischer Betreuer] Robel-Tillig, Ulf [Akademischer Betreuer] Bühligen, Roland [Gutachter] Pfäffle, and Karin [Gutachter] Rothe. "Analyse verschiedener Risikofaktoren und Prävalenzentwicklung der Gastroschisis im Zeitraum 2003 bis 2010 in Leipzig / Josefine Kruscha ; Gutachter: Roland Pfäffle, Karin Rothe ; Eva Robel-Tillig, Ulf Bühligen." Leipzig : Universitätsbibliothek Leipzig, 2015. http://d-nb.info/1239657250/34.
Повний текст джерелаGonçalves, Frances Lilian Lanhellas 1979. "Avaliação da proteção e tratamento das alças intestinais fetais utilizando hidrogel (biomaterial) e S-nitrosoglutationa (GSNO) no modelo experimental de gastrosquise." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310452.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Gastrosquise é um defeito congênito da parede abdominal anterior no qual as alças intestinais ficam herniadas e em contato com o líquido amniótico (LA) cuja exposição crônica resulta em várias disfunções intestinais no período pós-natal. Para reduzir o efeito danoso desta exposição utilizou-se em modelo animal, dosagens diferentes de S-nitrosoglutationa (GSNO), doador de óxido nítrico (NO) e para a concentração mais diluída acrescentou-se o hidrogel de N-isopropilacrilamida (NIPAAm) copolimerizado com ácido acrílico (Aac) para cobrir as alças fetais expostas fetais afim de avaliar o tratamento com NO e a proteção oferecida pelo biomaterial. A gastrosquise foi induzida cirurgicamente em fetos de ratas com 18,5 dias de gestação. Os fetos foram separados em dez grupos: controle externo (CE), gastrosquise (G), controle interno (CI), Sham (S), gastrosquise + adesivo de fibrina - Beriplast® (GA), gastrosquise + adesivo de fibrina + hidrogel seco (GAH), gastrosquise + GSNO a 50 µM (GNO1), gastrosquise + GSNO a 5 µM (GNO2), gastrosquise + GSNO a 0,5 µM (GNO3), gastrosquise + GSNO a 0,05 µM (GNO4), gastrosquise + adesivo de fibrina + hidrogel seco + GSNO a 0,05 µM (GAHNO4). Com 21,5 dias de gestação, os fetos foram colhidos por cesárea e o hidrogel foi cuidadosamente removido. Ao grupo GNO1 não foi dada continuidade, pois a dosagem foi nociva aos animais. Dados de peso corporal e intestinal foram aferidos e algumas amostras do intestino foram fixadas para estudo histométrico e imunoistoquímico e outras congeladas para western blotting e quimioluminescência. Resultados das medidas morfológicas e histométricas, como peso, diâmetro, espessura das camadas e da parede intestinal, demostraram que o grau de proteção e tratamento das alças intestinais foi eficaz nos grupos GAH e GAHNO4, pois apresentaram valores significamente menores, assim como os grupos CE e CI e diferente dos grupos G, GA, GNO2, GNO3 e GNO4 que indicaram processo inflamatório. A expressão das enzimas nNOS, iNOS e eNOS por meio de western blotting e imunoistoquímica dimunuiu principalmente nos grupos GAH, GNO4 e GAHNO4 ficando iguais aos grupos CE e CI. A quantificação de nitrato e nitrito (NOx) no intestino e no LA por quimioluminescência nos grupos G, CI e S, mostrou que o NO se difunde do tecido intestinal para o LA, no grupo G e isso pode ser a causa para o aumento da expressão da enzima NOS. Sendo assim, a aplicação do hidrogel aderido pelo adesivo de fibrina mostrou servir como uma efetiva proteção das alças herniadas e o tratamento concomitante com GSNO a 0,05 ?M também ajudou na redução significante da inflamação na gastrosquise
Abstract: Gastroschisis is a congenital defect of the anterior abdominal wall in which the herniated bowel is in contact with the amniotic fluid (LA) whose chronic exposure results in several postnatal bowel dysfunction. To reduce the harmful effect of this exposure it was used in an animal model, different doses of S-nitrosoglutathione (GSNO), donor of nitric oxide (NO) and the more dilute concentration was added to the hydrogel of N-isopropylacrylamide (NIPAAm) copolymerized acrylic acid (Aac) to cover the exposed fetal handles in order to assess fetal treatment with NO and the protection offered by the biomaterial. Gastroschisis was surgically induced in fetuses of female Sprague-Dawley rats at 18.5 days of gestation. The fetuses were separated into ten groups: external control (CE), gastroschisis (G) internal control (CI), Sham (S), gastroschisis + fibrin adhesive - Beriplast® (GA), gastroschisis + fibrin adhesive + dry hydrogel (GAH), gastroschisis + 50 µM GSNO (GNO1), gastroschisis + 5 µM GSNO (GNO2), gastroschisis + 0.5 µM GSNO (GNO3), gastroschisis + 0.05 µM GSNO (GNO4), gastroschisis + fibrin adhesive + dry hydrogel + to 0.05 ?M GSNO (GAHNO4). On day 21.5 of gestation, fetuses were collected by cesarean section and the hydrogel was carefully removed. The group GNO1 was not given continuity, because the dosage was harmful to the animals. Data of body weight and intestinal samples were measured and some intestinal samples were fixed for immunohistochemical and histometric study and the others were frozen for western blotting and chemiluminescence. Results of morphological and histometric measures such as weight, diameter and thickness of the intestinal wall, showed that the degree of protection and treatment of bowel was effective in groups GAH and GAHNO4 because they showed significantly lower values, as well as groups CE and CI and different from groups G, GA, GNO2, GNO3 and GNO4 that indicated inflammatory process. The expression of nNO, iNOS and eNOS enzymes by western blotting and immunohistochemistry decreased especially in groups GAH, GNO4 and GAHNO4, getting the same results as the CE and CI groups. Quantification of nitrate and nitrite (NOx) by chemiluminescence in the bowel and LA of groups G, S and CI showed that NO diffused from the intestinal tissue to LA in the group G and this may be the cause for the increased expression of the NOS enzymes. Therefore, the application of hydrogel joined by fibrin adhesive showed an effective protection of the herniated bowel and concomitant treatment with GSNO at 0.05 ?M, also helped in significant reduction in inflammation in gastroschisis
Doutorado
Fisiopatologia Cirúrgica
Doutor em Ciências
Simoni, Renata Zaccaria 1972. "Trombofilia hereditária em fetos com malformações de origem vascular = Genetic polymorphisms in fetuses with malformations of vascular origin." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309004.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Contexto e objetivo: Algumas malformações congênitas têm origem vascular, e a trombose durante a organogênese já foi aventada como possível mecanismo para esta ocorrência. O objetivo deste estudo foi avaliar a associação entre trombofilia fetal e malformações de origem vascular. Tipo de estudo e local: Foi realizado um estudo caso-controle, desenvolvido no ambulatório de Medicina Fetal do CAISM UNICAMP, de 2005 a 2010. Métodos: Foram incluídos no estudo 100 fetos com malformações de sistema nervoso central (SNC), gastrosquise, limb body wall e redução de membros (casos), submetidos a cordocentese como rotina do serviço, cujos resultados de cariótipo foram normais. Como controles, foram incluídos 100 fetos sem malformações cujo sangue de cordão fora previamente doado para o Banco de Sangue de Cordão do HEMOCENTRO UNICAMP. A pesquisa das mutações Fator V de Leiden, G20210A-FII e C677T-MTHFR foi realizada no sangue fetal dos dois grupos, e os resultados foram comparados. A análise descritiva foi feita utilizando Qui-quadrado e Teste Exato de Fisher. Para avaliar a associaçãoo entre as variáveis, foram utilizados o teste de Wilcoxon e a regressão logística. Resultados: Foram incluídos 78 fetos com malformações de SNC, 14 com gastrosquise, 3 com redução de membros e 2 com limb body wall. As mutações fator V de Leiden e G20210A-FII não foram encontradas nos casos e nos controles. A mutação C677T-MTHFR foi encontrada na forma heterozigota (CT) em 24 casos (24,8%) e em 6 controles. A mutação homozigota (TT) foi encontrada em 7 casos (7,2%) e em 1 controle. Estas diferenças foram estatisticamente significativas (p<0,0001). Quando avaliados os fetos com malformações de SNC (Artigo 1), a mutação CT foi encontrada com frequência significativamente maior nos casos do que nos controles (OR 10.309 IC95% 3.344-32.258), e a mutação TT também mostrou diferença significativa (OR 12.346 IC95% 1.388-111.11). A avaliação dos 14 fetos com gastrosquise (Artigo 2) não mostrou diferenças significativas quanto à presença da mutação CT ou TT entre os casos e os controles. Conclusão: A presença da mutação C677T-MTHFR no sangue fetal mostrou associação com malformações de SNC, tanto na forma homozigota quanto heterozigota
Abstract: Context and objective: Some congenital malformations have vascular origin, and a thrombosis during organogenesis is a possible mechanism for them. The aim of this study was to evaluate the association between fetal thrombophilia and malformations of vascular origin. Study type and location: A case-control study was performed at the Fetal Medicine Outpatient Clinic of CAISM UNICAMP, from 2005 to 2010. Methods: Ninety-seven fetuses with central nervous system malformations, gastroschisis, limb body wall and limb reduction were included in the study (cases), after routine cordocentesis showed normal karyotype results. A hundred fetuses without malformations were included as controls. These fetuses' cord blood had been donated to the Cord Blood Bank of HEMOCENTRO UNICAMP. DNA was extracted from fetal cord blood to study the mutations Factor V Leiden, G20210A-FII and MTHFR-C677T in both groups. Descriptive analysis was realized using Chi-square and Fisher's Exact Test. Wilcoxon test and logistic regression were used to analise the associations among variables. Results: We found 78 fetuses with central nervous system malformations, 14 with gastroschisis, 3 with member reduction and 2 with limb body wall. The mutations Factor V Leiden and G20210A-FII were not detected in cases nor in controls. The mutation MTHFR-C677T was encountered in 24 cases (24.8%) and in 6 controls its heterozygous form (CT). The homozygous mutation (TT) was found in 7 cases (7.2%) and in one control. These differences were statistically significant (p <0.0001). When the fetuses with central nervous system malformations were evaluated separately (Article 1), the frequency of the CT mutation was significantly higher in cases than in controls (OR 10.309 95% CI 3.344-32.258), as did the TT mutation (OR 12.346 95% CI 1.388-111.11). The 14 fetuses with gastroschisis were also evaluated separately (Article 2), and the results showed no statistically significant differences between cases and controls when concerning to the presence of the mutation MTHFR-C677T. Conclusion: The presence of the mutation MTHFR-C677T in fetal blood was associated with central nervous system malformations, both in homozygous and heterozygous form
Doutorado
Saúde Materna e Perinatal
Doutora em Ciências da Saúde
Trost, Stefanie [Verfasser], Matthias [Akademischer Betreuer] Knüpfer, Dietrich [Gutachter] Kluth, and Udo [Gutachter] Rolle. "Retrospektive Analyse des kurzfristigen Outcomes von Patienten mit Gastroschisis und Omphalocele am Zentrum für Kinder- und Jugendmedizin Leipzig / Stefanie Trost ; Gutachter: Dietrich Kluth, Udo Rolle ; Betreuer: Matthias Knüpfer." Leipzig : Universitätsbibliothek Leipzig, 2013. http://d-nb.info/123802081X/34.
Повний текст джерелаGarcia, Luciana de Freitas. "Gastrosquise fetal isolada: relação entre dilatação intestinal e resultados perinatais adversos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-06022012-174407/.
Повний текст джерелаObjectives: Evaluate bowel diameter as a predictor of adverse outcome in isolated fetal gastroschisis. Methods: Retrospective study involving 94 singleton pregnancies. Ultrasound measurements of herniated bowel transverse diameter (BTD) were performed up to 3 weeks before delivery. Adverse outcome was intrauterine/ neonatal death and/or bowel complications. Results: Last BTD was recorded at 35,6 ± 1,6 weeks and mean interval to delivery was 6,2 ± 5,0 days. Intrauterine/ neonatal death occurred in 10 (10,6%) cases; bowel complications were observed in 8 (8,5%). BTD 15, 20, 25 and 30mm were found in 87, 46, 13 and 4% of pregnancies with a favorable outcome, respectively. BTD 25 mm sensitivity was 38%, positive and negative predictive values, 38% and 87%. For BTD 30 mm, the values were: 19, 50 and 85%. Observed/expected BTD ROC curve showed an area of 0,67, with best cut-off at 1,39; prediction values were similar to those for BTD 25 mm. Bowel dilatation was also significantly associated with lower rate of primary surgical closure, longer period to full oral feeding and prolonged hospital stay. Conclusions: Bowel dilatation demonstrated up to 3 weeks before delivery is a predictor of intestinal complications and is associated with lower rate of primary surgical closure, longer period to achieve full oral feeding and hospital stay
Bremer, Sophia Alice [Verfasser], Wieland [Akademischer Betreuer] Kiess, Holger [Gutachter] Stepan, and Andreas [Gutachter] Merkenschläger. "Prävalenz von Gastroschisis, Omphalozele, Spina bifida und orofazialen Spaltbildungen bei Neugeborenen im Zeitraum Januar 2000 bis Dezember 2010 in Leipzig, Sachsen, Sachsen-Anhalt und Deutschland / Sophia Alice Bremer ; Gutachter: Holger Stepan, Andreas Merkenschläger ; Betreuer: Wieland Kiess." Leipzig : Universitätsbibliothek Leipzig, 2017. http://d-nb.info/1240701446/34.
Повний текст джерелаGonçalves, Frances Lilian Lanhellas 1979. "Avaliação da proteção das alças intestinais fetais utilizando hidrogel (biomaterial) no modelo experimental de gastrosquise." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310458.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: Gastrosquise é um defeito congênito da parede abdominal anterior no qual as alças intestinais ficam herniadas e em contato com o líquido amniótico (LA). Assim, a exposição ao LA resulta em várias disfunções intestinais pós-natal. Para reduzir o tempo de exposição ao LA em modelo animal, usou-se um hidrogel de N-isopropilacrilamida (NIPAAm) copolimerizado com ácido acrílico (Aac), que rapidamente intumesce na presença de LA. O hidrogel foi usado para cobrir as alças expostas até o fim da gestação. A gastrosquise foi induzida em fetos de ratas fêmeas da raça Sprague-Dawley através de um corte paramediano à direita do cordão umbilical para exposição parcial das alças com 18,5 dias de gestação. Os fetos foram separados em quatro grupos: controle (C), apenas gastrosquise (G), gastrosquise + cobertura das alças com adesivo de fibrina - Beriplast® (GA) e gastrosquise + cobertura das alças com adesivo de fibrina e aderido um pedaço de hidrogel seco (GAH). Os animais foram colhidos por cesárea com 21,5 dias de gravidez e o hidrogel foi cuidadosamente removido. Os fetos e as alças intestinais foram pesados e análise morfométrica foi realizada. Resultados mostraram que o hidrogel após intumescimento pesou 34X que seu peso seco; ele possui carga elétrica assim como a maioria das proteínas presentes no LA e sua retirada não provocou lesão à camada serosa do intestino exposto como visto na MEV. A comparação dos grupos C e GAH com os grupos G ou GA mostrou que o peso, o diâmetro, a espessura das camadas e da parede intestinais foi significativamente menor nos grupos C e GAH quando comparados aos grupos G e GA indicando processo inflamatório. Sendo assim, a aplicação do hidrogel aderido pelo adesivo de fibrina mostrou servir como uma efetiva proteção das alças herniadas, com uma redução significante da inflamação na gastrosquise.
Abstract: Gastroschisis is a congenital defect of the anterior abdominal wall which leads the fetal bowel to herniate into the amniotic cavity. There, exposition to amniotic fluid (AF), results in severe postnatal intestinal dysfunction. In order to reduce exposition time to AF in an animal model, has used a hydrogel of N-isopropylacrylamide (NIPAAm) copolymerized with acrylic acid (Aac), which undergoes rapid swelling in the amniotic fluid. The hydrogel was used to coat the bowel hernia until pregnance is completed. Gastroschisis was induced in the fetuses of female Sprague-Dawley rats by partial evisceration of the bowel through a right paramedian opening of the abdominal wall in day 18,5 of pregnancy. The fetuses were separated in four groups: control (C), gastroschisis alone (G), gastroschisis + coating of the bowel hernia with fibrin adhesive -Beriplast® (GA) and gastroschisis + coating of the bowel hernia with fibrin adhesive topped by a piece of adhered dry hydrogel (GAH). Animals were harvested by cesarean section at day 21.5 of pregnancy and the hydrogel was carefully removed. Fetuses and intestinal tract were weighed and morphometric analysis was performed. Results showed that the hydrogel weight was 34X heavier than its dry weight; its electric charge and also the AF charge were negative and there was no damage to serosa layer of the intestine exposed. Comparison of the C and GAH groups with G and GA showed that the bowel weight, diameter, the layers and wall thickness was significantly reduced in C and GAH compared to G and GA. Thus, application of the hydrogel bound onto the fibrin adhesive was shown to provide an effective protection of the herniated bowel, with a significant reduction of inflammation in gastroschisis.
Mestrado
Pesquisa Experimental
Mestre em Cirurgia
Fromm, Frederik Felipe [Verfasser]. "Fetoscopic abdominal decompression of congenital diaphragmatic hernia – a proof of concept study and stereological analysis based on morphological pulmonary changes in an ovine animal model : Pilotstudie über die abdominelle Dekompression einer Zwerchfellhernie durch iatrogene Gastroschisis -Teschnische Machbarkeit und Lungenveränderungen am fetalen Schafmodell / Frederik Felipe Fromm." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2019. http://d-nb.info/1225711584/34.
Повний текст джерелаCentofanti, Sandra Frankfurt. "Avaliação do padrão nutricional e níveis séricos de ácidos graxos nas gestantes portadoras de fetos com gastrosquise." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-05122018-120715/.
Повний текст джерелаObjective: To evaluate the nutrients intake during the preconceptional period and the serum fatty acid levels during the gestation period of pregnant women with fetuses with gastroschisis and pregnant women with normal fetuses. Methods: A prospective case-control study was conducted at the Fetal Medicine Unit at Hospital das Clínicas from July 2013 to July 2015. The gastroschisis group (GG) comprised 57 pregnant women with singleton pregnancies of less than 34 weeks with fetuses with isolated gastroschisis, and the control group (CG) comprised 114 pregnant women with normal fetuses matched for maternal age (± 2 years), gestational age (± 2 weeks), and the same preconceptional body mass index (BMI). Nutritional assessments related to the preconceptional period were obtained using the Food Consumption Frequency Questionnaire and nutrient intakes (macronutrient, micronutrient, fatty acid and amino acid) were calculated using nutrition programs: Dietwin Profissional 20 ® and Virtuanutri ®. For the evaluation of serum fatty acid levels (FA), a blood sample was collected from each subject at the time they entered the study and at the time of delivery. The FA comparison was performed during gestation and at the time of delivery. In order to evaluate whether the differences between both groups were more frequent in the first or second half of gestation, a new analysis was performed, subdividing gesta 25 weeks and < 34 weeks. Results: during the preconceptional period, the median daily calorie intake was higher (2382.43 versus 2198.81; p = 0.041) in the GG than in the CG. The median intakes of methionine (763.89 versus 906.34; p = 0.036), threonine (1248.34 versus 1437.01; p = 0.018) and chromium (54.66 versus 59.49 p = 0.014) were lower in the GG than in the CG. By analyzing the serum fatty acid levels, total FA (p = 0.008), unsaturated FA (p = 0.002) and the C18:1n9/C18:00 ratio (p = 0.021) were lower in the GG than in the CG during gestation; however, the C16:00 / C18:2n6 ratio (p = 0.018) was higher in the GG than in the CG during the indicated period. Total FA (p = 0.044) and unsaturated FA (p = 0.024) were lower in the GG than in the CG at period <= 25 w k , and unsaturated FA (p = 0.025) and the C18:1n9/C18:00 ratio (p = 0.013) were lower in the GG than in the CG at period > 25 weeks and < 34 weeks. Conclusion: Pregnant women with fetuses with gastroschisis have low-nutritional-quality diet, which is both high in calories and poor in essential amino acids during the preconceptional period, and have low serum FA levels during pregnancy
Centofanti, Sandra Frankfurt. "Gastrosquise: avaliação do padrão de crescimento fetal e predição de baixo peso no nascimento." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-14012015-145155/.
Повний текст джерелаINTRODUCTION: Gastroschisis is a congenital abdominal wall defect of the fetus and one of its main complications is related to fetal growth restriction. OBJECTIVES: Primary: To evaluate the growth pattern of fetuses with gastroschisis according to each biometric parameter; Secondary: to evaluate growth deficit in three gestational periods and to predict low birth weight from measures of biometric parameters below the 10th percentile. METHODS: This is a retrospective cohort study. We selected 70 cases for evaluation of the growth pattern. The measurements of each biometric parameter: head circumference, abdominal circumference, femur length, head circumference/abdominal circumference ratio and estimated fetal weight were plotted in a growth chart for comparison with the curve of normality. The percentage difference between the mean values of the fetuses with gastroschisis in relation to normal fetuses was then determined. For the evaluation of growth deficit 59 cases with at least one exam in each gestational period (I: 20 to 25 weeks and 6 days; II: 26 to 31 weeks and 6 days; III: 32 weeks until delivery) were included. The deficit of each biometric parameter was obtained from the comparison between these gestational periods. For the prediction of low birth weight, the measures below the 10th percentile of each biometric parameter in periods I and II were tested. RESULTS: In the evaluation of the growth pattern a significant difference between the fetuses with gastroschisis and normal fetuses from 20 weeks of gestation (p < 0.005) is observed. In the evaluation of growth deficit only estimated fetal weight showed a significant difference (p= 0.030). The percentage of fetuses with estimated fetal weight values below 10 percentile in period 2 was 40% higher than that in period I, and 93% higher in period III than in I. In the prediction of low birth weight, only head circunference (odds ratio= 6.07; sensitivity= 70.8 %; specificity = 71.4 %) and abdominal circunference (odds ratio= 0.558; sensitivity = 41.7 %; specificity = 80 %) in period II were predictive. CONCLUSION: Fetuses with gastroschisis show biometric parameters measures significantly smaller than the measures of normal fetuses with 20 weeks of gestation and/or more. In the evaluation of growth deficit, there is a higher incidence of fetal growth restriction in periods II and III. It is possible to predict newborns with low birth weight from measures of head circunfernce and abdominal circunference below the 10th percentile in period II
Sekabira, John. "Gastroschisis in KwaZulu-Natal." Thesis, 2008. http://hdl.handle.net/10413/9610.
Повний текст джерелаThesis (M.Med.)-University of KwaZulu-Natal, Durban, 2008.
Kruscha, Josefine. "Analyse verschiedener Risikofaktoren und Prävalenzentwicklung der Gastroschisis im Zeitraum 2003 bis 2010 in Leipzig." Doctoral thesis, 2014. https://ul.qucosa.de/id/qucosa%3A13494.
Повний текст джерелаValente, Lília Patrícia de Mendonça. "Gastroschisis: factors influencing 3-year survival and digestive outcome." Master's thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/78849.
Повний текст джерелаValente, Lília Patrícia de Mendonça. "Gastroschisis: factors influencing 3-year survival and digestive outcome." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/78849.
Повний текст джерелаMüller, Marc [Verfasser]. "Fetalchirurgischer Verschluss der Gastroschisis im Kaninchenmodell / vorgelegt von Marc Müller." 2009. http://d-nb.info/994042655/34.
Повний текст джерелаFranz, Andrea. "Gastroschisis und Omphalocele im zeitlichen Wandel von 1972 bis 2002." Doctoral thesis, 2006. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-21612.
Повний текст джерелаFrom 1972 to 2002 66 children with gastroschisis and 48 children with Omphalocele were treated at the department of Pediatric Surgery at the University Hospital of Würzburg. In a retrospective analysis we examined the perinatal management and outcome of those children. In the last two decades there has been an increase of cases with gastroschisis whereas cases of omphalocele decreased. Mothers less than 25 years old and primigravida were at a greater risk to get a child with gastroschisis. The maternal age in the omphalocele group was 26 years and older. We could not identify a risk factor for gastroschisis or omphalocele in our studies. An antenatal diagnosis by ultrasound was made in 0% from 1972 to 1988, whereas in the last few years 90% of the cases with abdominal wall defects have been detected before birth. The mode of delivery changed completely in the last 10 years: Until 1982 all children with gastroschisis or omphalocele were born vaginally. After 1993 all except 2 babies were delivered by cesarean section and most of them were premature. After birth the babies suffered because of the prematurity, in the gastroschisis group there were more cases with gastrointestinal dysfunction, in the omphalocele group the newborns suffered from associated anomalies, specially cardiac anomalies or complex syndromes. In the last 10 years primary closure was possible in 65 % of the children with abdominal wall defects. If the defect was too large and primary fascial closure was impossible, the abdominal wall was closed using a dura implantation (until 1996) or a Goretex patch (since 1997). After surgical treatment children with gastroschisis had a higher rate of relaparotomy because of gastrointestinal complications. Therefore those children had a longer interval of total parenteral nutrition and length of stay at the hospital than children with omphalocele. Mortality rate of children with abdominal wall defects decreased to less than 10% with sepsis being the most common reason. About 50% of the children with gastroschisis or omphalocele could be examined in 2003 by answering a questionnaire. The follow-up (6 months to 5,5 years old children) shows normal growth and development of the children except for those with severe associated anomalies or syndromes. All others are participating without problems in normal activity and education without reduction in their quality of life. Today isolated cases of gastroschisis or omphalocele have a good prognosis. There has been an improvement of prenatal diagnostics, peripartal managemant, surgical repair and perioperative treatment in the last decade. If an abdominal wall defect is diagnosed, obstetricians, neonatologists and pediatric surgeons should be involved by consulting the parents
Trost, Stefanie. "Retrospektive Analyse des kurzfristigen Outcomes von Patienten mit Gastroschisis und Omphalocele am Zentrum für Kinder- und Jugendmedizin Leipzig." Doctoral thesis, 2011. https://ul.qucosa.de/id/qucosa%3A11344.
Повний текст джерелаBremer, Sophia Alice. "Prävalenz von Gastroschisis, Omphalozele, Spina bifida und orofazialen Spaltbildungen bei Neugeborenen im Zeitraum Januar 2000 bis Dezember 2010 in Leipzig, Sachsen, Sachsen-Anhalt und Deutschland." Doctoral thesis, 2016. https://ul.qucosa.de/id/qucosa%3A15367.
Повний текст джерелаFranz, Andrea [Verfasser]. "Gastroschisis und Omphalocele im zeitlichen Wandel von 1972 bis 2002 / vorgelegt von Andrea Franz." 2007. http://d-nb.info/983173877/34.
Повний текст джерелаBeckh-Arnold, Elaine Mary Philippa. "Gastroschisis and Omphalocoele: audit at two referral Hospitals in Johannesburg, South Africa: 2000-2005." Thesis, 2011. http://hdl.handle.net/10539/10847.
Повний текст джерелаMarques, Alexandra Tavares. "Short and medium term outcomes of omphalocele and gastroschisis: a survey of a tertiary center." Master's thesis, 2021. https://hdl.handle.net/10216/134514.
Повний текст джерелаObjective: To characterize and compare the outcomes of omphalocele and gastroschisis from birth to 2-year of follow-up in a recent cohort at a tertiary center. Methods: This is a retrospective clinical record review of all patients with gastroschisis and omphalocele, admitted to the Neonatal Intensive Care Unit between January 2009 and December 2019. Results: There were 38 patients: 13 with omphalocele and 25 with gastroschisis. Associated anomalies were present in 6 patients (46.2%) with omphalocele and in 10 (41.7%) with gastroschisis. Compared to patients with omphalocele, those with gastroschisis had younger mothers (24.7 vs. 29.6 years; p = 0.033), were born earlier (36 vs. 37 weeks, p = 0.006), with smaller birth weight (2365 430.4 vs. 2944.2 571.9 g; p = 0.001) and had a longer hospital stay (24 vs. 9 days, p = 0.001). The neonatal survival rate was 92.3% for omphalocele and 91.7% for gastroschisis. Thirty-four patients were followed-up over a median of 24 months: 13 with gastroschisis (59.1%) and 8 with omphalocele (66.7%) had at least one adverse event, mainly umbilical hernia (27.3% vs 41.7%), intestinal obstruction (31.8% vs 8.3%) and additional surgical interventions (27.3% vs 33.3%). Conclusion: Despite the high proportion of prematurity, low birth weight and protracted recovery, gastroschisis as well as omphalocele (without chromosomal abnormalities) may achieve very high survival rates; on the other hand, complications may develop in the first years of life. Thus, a very positive perspective in terms of survival should be transmitted to future parents, but they should also be informed that substantial morbidity may occur in medium-term.
Marques, Alexandra Tavares. "Short and medium term outcomes of omphalocele and gastroschisis: a survey of a tertiary center." Dissertação, 2021. https://hdl.handle.net/10216/134514.
Повний текст джерелаObjective: To characterize and compare the outcomes of omphalocele and gastroschisis from birth to 2-year of follow-up in a recent cohort at a tertiary center. Methods: This is a retrospective clinical record review of all patients with gastroschisis and omphalocele, admitted to the Neonatal Intensive Care Unit between January 2009 and December 2019. Results: There were 38 patients: 13 with omphalocele and 25 with gastroschisis. Associated anomalies were present in 6 patients (46.2%) with omphalocele and in 10 (41.7%) with gastroschisis. Compared to patients with omphalocele, those with gastroschisis had younger mothers (24.7 vs. 29.6 years; p = 0.033), were born earlier (36 vs. 37 weeks, p = 0.006), with smaller birth weight (2365 430.4 vs. 2944.2 571.9 g; p = 0.001) and had a longer hospital stay (24 vs. 9 days, p = 0.001). The neonatal survival rate was 92.3% for omphalocele and 91.7% for gastroschisis. Thirty-four patients were followed-up over a median of 24 months: 13 with gastroschisis (59.1%) and 8 with omphalocele (66.7%) had at least one adverse event, mainly umbilical hernia (27.3% vs 41.7%), intestinal obstruction (31.8% vs 8.3%) and additional surgical interventions (27.3% vs 33.3%). Conclusion: Despite the high proportion of prematurity, low birth weight and protracted recovery, gastroschisis as well as omphalocele (without chromosomal abnormalities) may achieve very high survival rates; on the other hand, complications may develop in the first years of life. Thus, a very positive perspective in terms of survival should be transmitted to future parents, but they should also be informed that substantial morbidity may occur in medium-term.
Frýbová, Barbora. "Predikce poškození střeva u novorozenců s gastroschízou." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-404567.
Повний текст джерелаSilva, Ana Margarida Arantes. "Onfalocelo e gastrosquise: estudo de casos diagnosticados na MBB." Master's thesis, 2019. http://hdl.handle.net/10316/89815.
Повний текст джерелаIntrodução: a gastrosquise e o onfalocelo são as malformações major congénitas daparede abdominal anterior mais frequentes e caracterizam-se por herniação das vísceras. Porserem patologias distintas, a melhor caracterização e compreensão destas e dasmalformações associadas é importante de forma a melhorar a abordagem e seguimentodestes doentes e consequentemente aumentar a sobrevida e a qualidade de vida.Objetivo: determinar a incidência de onfalocelos e gastrosquises na Maternidade BissayaBarreto (MBB), caracterizar os casos diagnosticados, bem como a avaliação da sua evoluçãocirúrgica no Hospital Pediátrico de Coimbra (HPC).Metodologia: foram estudados retrospetivamente todos os casos diagnosticados comogastrosquise ou onfalocelo na MBB e posteriormente seguidos no HPC, no período decorridoentre janeiro de 1991 e dezembro de 2017.Resultados: de um total de 78 defeitos diagnosticados, 52 correspondem a onfalocelose 26 a gastrosquises, sendo a prevalência de 6,53 e 3,26:10000 nascimentos, respetivamente.Dos nados vivos (41), 49% apresentavam onfalocelos e 51% gastrosquises, sendo aprevalência de 2,51 e 2,63:10000 nascimentos, respetivamente. A taxa de deteção estesdefeitos em período pré-natal foi de 94%. A percentagem de óbitos fetais foi 61% dosonfalocelos e 19% das gastrosquises. Na totalidade dos casos, as malformações associadasestiveram presentes em 80% dos casos de onfalocelos e 35% de gastrosquises. Aprematuridade registou-se em 37% dos onfalocelos e 71% dos gastrosquises. A abordagemcirúrgica mais utilizada foi redução com encerramento primário (63% dos onfalocelos e 95%das gastrosquises). Dos onfalocelos 3/17 e das gastrosquises 7/21 necessitaram dereintervenção cirúrgica. Registaram-se 21% de óbitos no grupo dos onfalocelos e, comosequelas, 14% de síndromes de intestino curto no grupo das gastrosquises.Conclusões: o diagnóstico pré-natal (DPN) é de suma importância de forma a aumentara sobrevida e a qualidade de vida dos doentes com estes defeitos. Devido ao protocoloestabelecido entre a MBB e os cuidados de saúde primários da sua área de influência, a taxade deteção neonatal destes defeitos foi muito elevada. Por fim, a avaliação destas gravidezesnum centro de apoio perinatal diferenciado com ligação ao serviço de pediatria cirúrgicapermite uma orientação célere de forma a melhorar o prognóstico destes recém-nascidos.
Introduction: omphaloceles and gastroschisis are the most common congenitalabdominal wall defects represented by the extra peritoneal herniation of the abdominal viscera.Since they are different pathologies it is importante to have a full understanding of theircharacteristics and associated malformations, in order to chose the best treatment, andconsequently have the best prognosis and quality of life.Objective: to determine the incidence of omphaloceles and gastroschisis in the MBB,characterise the cases diagnosed and evaluate their cirurgical evolution in the HPC.Methodology: retrospective study of all cases diagnosed at the MBB as omphaloceles orgastroschisis which later were followed at the HPC in the period between January 1991 andDecember 2017.Results: In a total of 78 diagnosed defects, 52 corresponded to omphaloceles and 26 togastroschisis, being the prevalence of 6,53 and 3,26: 10 000 births, respectively. Regardinglive births (41), 49% had omphalocele and 51% gastroschisis, with a prevalence of 2,51 and2,63: 10 000 births, respectively. The rate of detection of these defects in the prenatal periodwas 94%. The percentage of fetal deaths was 61% of omphaloceles and 19% of gastroschisis.In our case serie, the associated malformations were present in 80% of cases of omphalocelesand 35% of gastroschisis. Prematurity was present in 37% of omphaloceles and 71% ofgastroschisis. The most used surgical approach was reduction with primary closure (63% ofomphaloceles and 95% of gastroschisis). Surgical reintervetion was required in 3/17omphaloceles and in 7/21 gastroschisis. There were 21% of deaths in the omphafolecelesgroup and, as sequels, 14% of short bowel syndromes in the gastroschisis group.Conclusions: prenatal diagnosis is extremely important in order to increase the survivaland quality of life of patients with these defects. Due to the protocol established between MBBand the primary care of its influence area, the rate of neonatal detection of these defects wasvery high. Finally, the evaluation of these pregnancies in a differentiated perinatal supportcenter with connection to the surgical pediatric service allows a quick orientation in order toimprove the prognosis of these newborns.