Дисертації з теми "Gamma-sterilization"
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TSAI, DAVID. "Aplicação da radiação por feixe de elétrons como agente esterilizante de microrganismos em substrato turfoso." reponame:Repositório Institucional do IPEN, 2006. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11407.
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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
Dux, Stephanie J. "The Effect of Gamma Radiation Sterilization on Yield Properties and Microscopic Tissue Damage in Dense Cancellous Bone." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1254317910.
Повний текст джерелаShuster, Mark D. "Physical and Chemical Modifications of Free Radical Scavengers to Reduce their Radioprotective Potentials for Bacterial Agents." University of Toledo / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1134418758.
Повний текст джерелаKhan, Brandon Sajad. "The Effects of Gamma (γ-) Sterilization on the Redox Stability, Minerology, and Physicochemical Properties of the Synthetic Iron Oxides Ferrihydrite, Lepidocrocite, and Goethite". Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36519.
Повний текст джерелаFONTES, LUCIA da S. "Efeitos da radiacao gama do cobalto-60 nas fases do ciclo evolutivo de tribolium castaneum (Herbst.,1797) (Coleoptera-Tenebrionidae)." reponame:Repositório Institucional do IPEN, 1994. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10354.
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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
SOUZA, MARIA D. C. A. de. "Efeito da radiacao gama sobre a aguardente de cana-de-acucar." reponame:Repositório Institucional do IPEN, 2000. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10801.
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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
OMI, NELSON M. "Geracao de um aplicativo para simulacao de doses em sistemas de irradiacao gama." reponame:Repositório Institucional do IPEN, 2000. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9280.
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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
SOARES, JOSE R. "Desenvolvimento de sistema para seguimento de produto e aquisicao de dados do processo de irradiacao em irradiadores de grande porte." reponame:Repositório Institucional do IPEN, 2010. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11531.
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Tese (Doutoramento)
IPEN/T
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
Galante, Raquel. "Esterilização de hidrogéis para aplicações biomédicas." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-13072017-164922/.
Повний текст джерелаSterility is mandatory requirement for most biomaterials. Because of their known sensitivity, hydrogel sterilization poses as a challenge, particularly when it comes to nanostructures or when drugs are incorporated. The main goal of this work was to study the key effects of different sterilization methods on the properties of different types of hydrogel-based systems. In addition to the conventional methods (steam heat and gamma radiation) the applicability of a promising new ozone method was assessed. Two formulations of synthetic hydrogels for ophthalmic applications (representing conventional contact lenses and new generation silicone-hydrogel contact lens), unloaded and loaded with ophthalmic drugs, were studied; and a natural chitosan-based nanostructured hydrogel (nanogel), with a broad spectrum of possible applications. Changes in the essential properties were evaluated. For synthetic hydrogels: swelling, optical properties, ionic permeability, wettability, morphology and topography, chemical structure, mechanical properties, cytotoxicity and drug release profile. For the nanogel: average particle size, zeta potential, polydispersity index, absorbance, morphology, chemical structure and cytotoxicity. In order to ensure the effectiveness of the sterilization methods, sterility tests were carried out after purposely contaminating the samples with different loads of biological indicators. Seam heat sterilization proved to be the most aggressive method for the nanogel, while being the least aggressive for the synthetic hydrogels in the presence and absence of drugs. Regarding gamma irradiation, the nanogel resistance to irradiation increased considerably in the presence of protective sugars. The synthetic hydrogels were resistant to this technique, showing signs of severe degradation only at the highest dose (25 kGy). In the presence of drugs, gamma irradiation proved to be inadequate due to drug degradation. The obtained results were encouraging with regard to the applicability of ozone sterilization for both the nanogel and the unloaded synthetic hydrogels. The drugs generally undergo degradation when exposed to this oxidizing agent. In view of the evident complexity of the factors involved (e.g. nature, composition and properties of materials, drug stability, conditions and parameters of sterilization processes), it is difficult to generalize the effects and predict the outcome of the sterilization methods. The selection of the most suitable procedure must be made on a case-by-case basis.
Souza, Rafael Queiroz de. "Análise in vitro da toxicidade celular de tubos de PVC esterilizados consecutivamente em raios gama e óxido de etileno." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/7/7139/tde-12082010-143158/.
Повний текст джерелаIn 1967, a letter sent to the British Medical Journal reported that the re-sterilization with Ethylene Oxide (EtO) of previously irradiated Polyvinyl Chloride (PVC) formed large amounts of ethylene chlorohydrin, a highly toxic compound. Even though it did not present measured data, this letter initiated a controversy that still divide the opinion of researchers to date. To solve this doubt is relevant, as PVC products submitted to gamma radiation are usually re-sterilized with EtO, when the sterilization validity has expired, which is determined by the manufacturer. The present study aimed at assessing the toxicity of PVC tubes through the cytotoxicity test, using the NCTC clone 929 cell culture agar diffusion test. Four experimental groups were created with 81 analysis units: G1, consisting of tubes in natura; G2, consisting of tubes submitted to gamma radiation; G3, consisting of tubes submitted to EtO sterilization and G4, consisting of tubes submitted to gamma-radiation and re-sterilized with EtO. The tests were carried out in triplicate and each tube was tested in order to represent its internal and external surfaces, as well as its mass. After the measurement of the colorless halo, the analysis units were graded according to the degrees of biological reactivity described in the ISO 10993-5:2009. Only the analysis units that were considered grade 3 and above were considered cytotoxic. The results showed evidence of cell toxicity only in G3, which disclosed plaques that presented death of all cells, a fact that necessitated repetition of the experiment, according to the adopted methodology. The first repetition showed the persistence of the analysis units to cause the death of all cells in the plaque. At the second repetition, none of the analysis units was classified as being cytotoxic. It was inferred that there were failures in the process of aeration in group G3 and in the first repetition. The results of the gas chromatography of groups G3 and G4 demonstrated that the materials from both groups would be safe for use. The maximum value of residues found in both groups was identical, in disagreement with the cytotoxicity test results. It was concluded that, according to the conditions of this experiment, the PVC materials submitted to gamma-radiation and consecutively sterilized by EtO are not cytotoxic and that the gas chromatography, when used alone, can yield debatable results regarding the safety of materials sterilized with EtO.
Porto, Karina Meschini Batista Geribello. "Efeitos da radiação gama (cobalto-60) nas principais propriedades físicas e químicas de embalagens compostas por papel grau cirúrgico e filme plástico laminado, destinada à esterilização de produtos para saúde." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-26112013-102247/.
Повний текст джерелаGamma radiation is one of the technologies applied for the sterilization of packaging systems containing products for health. During sterilization process it is critical that the properties of packages are maintained. In this study two samples of commercial pouch packaging comprised of surgical grade paper on one side and the other side multilayer plastic film were irradiated with gamma rays. The following doses were applied 25 kGy (1,57 kGy/h) and 50 kGy (1,48 kGy/h). One packaging sample was paper formed by softwood fibers and multilayer plastic film based on poly(ethylene terephthalate) (PET)/polyethylene (PE). The second type of paper sample was made by a mixture of softwood and hardwood fibers and multilayer plastic film based on polyethylene terephthalate (ethylene) (PET)/polypropylene (PP). The effects of radiation on the physical and chemical properties of papers and multilayer plastic films, as well as the properties of the package were studied. The paper was the more radiation sensitive among the studied materials and radiation effects were more pronounced at brightness, pH, tearing resistance, bursting strength and tensile strength. Nonetheless, worst comparatively effects were noted on the sample made by a mixture of softwood and hardwood fibers. The porosity of paper was enhanced by 50 kGy. In the case of plastic films, radiation effects on tensile strength was the most pronounced property for both samples. In the case of the packaging the sealing resistance decreased with radiation. The effects observed for the treatment at 50 kGy were more pronounced when compared to 25 kGy. This last is the dose which is usually applied to sterilize health products. A dosimetry study was performed during irradiation at 25 kGy, 40 kGy and 50 kGy and its importance may be reported by the average dose variation 20 %.
PORTO, KARINA M. B. G. "Efeitos da radiação gama (sup(60)Co) nas principais propriedades físicas e químicas de embalagens compostas por papel grau cirúrgico e filme plástico laminado, destinadas à esterilização de produtos para saúde." reponame:Repositório Institucional do IPEN, 2013. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10575.
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Dissertação (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
RAGA, ADALTON. "Incidencia de moscas-das-frutas em cafe e citros e tratamento quarentenario de frutos citricos com radiacao gama." reponame:Repositório Institucional do IPEN, 1996. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10484.
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Tese (Doutoramento)
IPEN/T
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
Pruß, Axel. "Chemische und physikalische Verfahren zur Inaktivierung von pathogenen Mikroorganismen in allogenen Knochentransplantaten." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/13951.
Повний текст джерелаShang-Chi, Chuang, and 莊上奇. "Evaluation of gamma-sterilization, dynamic cell seeding and the porcine model for modified polyurethane small-diameter vascular grafts." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/76980832227605986153.
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