Добірка наукової літератури з теми "Gamma-ammino acidi beta,beta-disostituiti"
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Статті в журналах з теми "Gamma-ammino acidi beta,beta-disostituiti"
Liakopoulou, E., CA Blau, Q. Li, B. Josephson, JA Wolf, B. Fournarakis, V. Raisys, G. Dover, T. Papayannopoulou, and G. Stamatoyannopoulos. "Stimulation of fetal hemoglobin production by short chain fatty acids." Blood 86, no. 8 (October 15, 1995): 3227–35. http://dx.doi.org/10.1182/blood.v86.8.3227.3227.
Повний текст джерелаLiakopoulou, E., CA Blau, Q. Li, B. Josephson, JA Wolf, B. Fournarakis, V. Raisys, G. Dover, T. Papayannopoulou, and G. Stamatoyannopoulos. "Stimulation of fetal hemoglobin production by short chain fatty acids." Blood 86, no. 8 (October 15, 1995): 3227–35. http://dx.doi.org/10.1182/blood.v86.8.3227.bloodjournal8683227.
Повний текст джерелаNishikawa, Koichi, та Neil L. Harrison. "The Actions of Sevoflurane and Desflurane on the γ-Aminobutyric Acid Receptor Type A". Anesthesiology 99, № 3 (1 вересня 2003): 678–84. http://dx.doi.org/10.1097/00000542-200309000-00024.
Повний текст джерелаDesai, Rooma, Dirk Ruesch та Stuart A. Forman. "γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity". Anesthesiology 111, № 4 (1 жовтня 2009): 774–84. http://dx.doi.org/10.1097/aln.0b013e3181b55fae.
Повний текст джерелаHusmann, M., J. Lehmann, B. Hoffmann, T. Hermann, M. Tzukerman, and M. Pfahl. "Antagonism between retinoic acid receptors." Molecular and Cellular Biology 11, no. 8 (August 1991): 4097–103. http://dx.doi.org/10.1128/mcb.11.8.4097-4103.1991.
Повний текст джерелаHusmann, M., J. Lehmann, B. Hoffmann, T. Hermann, M. Tzukerman, and M. Pfahl. "Antagonism between retinoic acid receptors." Molecular and Cellular Biology 11, no. 8 (August 1991): 4097–103. http://dx.doi.org/10.1128/mcb.11.8.4097.
Повний текст джерелаFriedrich, R. J., K. S. Campbell, and J. C. Cambier. "The gamma subunit of the B cell antigen-receptor complex is a C-terminally truncated product of the B29 gene." Journal of Immunology 150, no. 7 (April 1, 1993): 2814–22. http://dx.doi.org/10.4049/jimmunol.150.7.2814.
Повний текст джерелаPace, B., Q. Li, K. Peterson, and G. Stamatoyannopoulos. "alpha-Amino butyric acid cannot reactivate the silenced gamma gene of the beta locus YAC transgenic mouse." Blood 84, no. 12 (December 15, 1994): 4344–53. http://dx.doi.org/10.1182/blood.v84.12.4344.bloodjournal84124344.
Повний текст джерелаMunck, B. G., L. K. Munck, S. N. Rasmussen, and A. Polache. "Specificity of the imino acid carrier in rat small intestine." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 266, no. 4 (April 1, 1994): R1154—R1161. http://dx.doi.org/10.1152/ajpregu.1994.266.4.r1154.
Повний текст джерелаGugneja, S., J. V. Virbasius, and R. C. Scarpulla. "Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain." Molecular and Cellular Biology 15, no. 1 (January 1995): 102–11. http://dx.doi.org/10.1128/mcb.15.1.102.
Повний текст джерелаДисертації з теми "Gamma-ammino acidi beta,beta-disostituiti"
Venneri, Cesare Daniele. "Sintesi stereoselettiva mediata da enzimi di analoghi lineari e ciclici dell'acido Ÿ- amminobutirrico." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3517.
Повний текст джерелаE’ stata sviluppata una sintesi enantioselettiva facile e rapida di una serie di analoghi del GABA beta-sostituiti e beta,beta’-disostituiti potenzialmente utili, a partire da precursori gamma-nitro esterei racemi facilmente disponibili, attraverso la loro risoluzione cinetica enzimatica. L'applicazione della procedura descritta al substrato che reca in posizione beta il raggruppamento isobutilico consente di ottenere il composto terapeuticamente utile (S)-(+)-Pregabalina e la sua controparte enantiomerica; la medesima strategia sintetica applicata al substrato beta,beta’-disostituito con i gruppi metile e isobutile conduce all’analogo tetrasostituito della stessa Pregabalina, mentre il substrato recante in beta,beta’ il gruppo 3-metilcicloesile permette l’ottenimento di un analogo chirale della Gabapentina (Neurontin®) e del suo enantiomero. L’interesse verso la sintesi di gamma-amminoacidi beta,beta’-sostituiti risiede non solo nella potenziale attività biologica dei composti target, analoghi chirali della Gabapentina, ma è anche in relazione al problema sintetico connesso con l’ottenimento di composti chirali in cui l’atomo di carbonio asimmetrico è quaternario. I risultati ottenuti sono di notevole interesse anche alla luce della nota riluttanza delle comuni idrolasi a riconoscere e trasformare substrati in cui il centro chirale adiacente alla funzione idrolizzabile è completamente sostituito. La medesima procedura rappresenta inoltre una strategia sintetica alternativa per acidi 2-alchilsuccinici otticamente attivi, che possono essere così ottenuti in condizioni relativamente blande. Infatti la trasformazione di un nitrocomposto primario in un acido carbossilico, nota come reazione di Victor Meyer, richiede condizioni drastiche, cioè trattamento a riflusso con acidi minerali, oppure laboriose procedure di sintesi. Gli acidi succinici, oltre a manifestare varie attività a livello biologico, sono utili intermedi sintetici per importanti building blocks omochirali come beta-lattami, beta- e gamma-lattoni, succinimidi, anidridi succiniche. Nell’ambito della sintesi degli analoghi del GABA beta,beta’-sostituiti, inoltre, parallelamente al lavoro con gli enzimi è stata sviluppata un’addizione coniugata diretta e altamente enantioselettiva di un nitroalcano ad un’aldeide alfa,beta-insatura usando difenilprolinol silil etere come organocatalizzatore, per ottenere un intermedio prontamente convertito nell’amminoacido target. Questa concisa, pratica ed efficiente procedura sintetica si ritiene possa trovare ampia applicabilità nella sintesi stereoselettiva di altri composti recanti un carbonio quaternario chirale, di difficile ottenimento, e, in particolare, di altri gamma-amminoacidi beta,beta-dialchilati enantiopuri di interesse chimico e farmaceutico. Si presenta infine un’efficiente sintesi dell’acido 2-carbossi-3-pirrolidinacetico, gamma-amminoacido conformazionalmente costretto e importante agonista del recettore NMDA (N-metil-D-aspartato) che costituisce lo scheletro degli acidi kainici, dotati, fra le varie azioni biologiche, di attività neuroeccitatoria. La strategia sintetica proposta conduce ad elevati eccessi enantiomerici e rese soddisfacenti.
XXII Ciclo
1981
Abarbri, Mohamed. "Acides Alpha-Beta et Beta-Gamma insaturés : préparation, réactivité et utilisation en synthèse organique." Tours, 1995. http://www.theses.fr/1995TOUR4014.
Повний текст джерелаZhang, Jing. "Synthesis of phosphinic acids and aza-beta and gamma-lactams as potential inhibitors of bacterial D,D-peptidases and beta-lactamases." Université catholique de Louvain, 2003. http://edoc.bib.ucl.ac.be:81/ETD-db/collection/available/BelnUcetd-09292003-151944/.
Повний текст джерелаGrison, Claire. "Peptides-beta/gamma mixtes : nouveaux édifices foldamères pour mimer l'hélice-alpha." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS128/document.
Повний текст джерелаThis thesis is devoted to the synthesis and the structural characterisation of beta/gamma-peptides, constructed from beta- and gamma-amino acids in alternation, designed to mimic the alpha-helix secondary structure which is present in many native proteins. The alpha-helix can be defined as a 13-helix and a bottom-up foldamer design strategy to target a 13-helical structure was examined, whereby beta/gamma-peptides were proposed in which (1S,2S)-trans-2-aminocyclobutanecarboxylic acid (trans-ACBC) was incorporated as a conformationally-restricted beta-amino acid component. The scalable synthesis of enantiomerically pure trans-ACBC using a [2+2] photocycloaddition strategy was successfully optimized. beta/gamma-Peptides incorporating trans-ACBC and GABA, the latter being the gamma-amino acid component devoid of any constraint, were then synthesised. Experimental and theoretical investigations of their solution-state folding behaviour revealed an unprecedented 9/8-ribbon foldamer structure that adopts curved shapes governed by a combined configuration-conformation code. Additional constraints on the gamma-amino acid component were then considered and beta/gamma-peptides incorporating trans-ACBC and gamma4-amino acids were synthesised. Experimental and theoretical investigations of these beta/gamma-peptides in solution unveiled a preference for 13-helix folding behaviour, which increased commensurately with the peptide chain length; robust 13-helices were stabilised by a minimum of five intramolecular hydrogen bonds. In the last part of this thesis, molecular modelling was used to design helical alpha/beta/gamma-peptides intended to reproduce as closely as possible the hot-spot residues of the known alpha-helical peptide sequence p53(15-31). These peptides were synthesised and their predicted helical folding was verified experimentally along with their resistance to proteolytic enzymes. The alpha/beta/gamma-peptides were tested as inhibitors of the p53/hDM2 interaction. One peptide was found to behave as potent inhibitor and to bind to the native peptide binding pocket of the hDM2 protein, providing a successful proof of concept of the alpha-helix mimetic design strategy
Chapman, Mark Andrew. "The synthesis of #beta#,#gamma#-ethynyldiaminopimelic acid analogues as potential chemotherapeutic agents." Thesis, University of Sunderland, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294051.
Повний текст джерелаTercinier, Pierre. "Etude de la préparation et de la réactivité des 2,3-aziridino-γ-lactones : approche à la synthèse de l’apto, acide ß-amine composant des microsclérodermines C et D". Paris 11, 2007. http://www.theses.fr/2007PA112080.
Повний текст джерелаThe work described in this thesis concems the synthesis and reactiviy of chiral bicyclic compounds, 2,3gamma-Iactones, and their use in the preparation ofpolysubstituted beta-amino acids. The reactivity of 2,3-aziridino-gamma-Iactones with soft carbon nucleophiles such as organocuprates was first studied. Different aziridines were prepared and reacted with various carbon nucleophiles. A methyl group was successfully introduced at the C-2 position but this was accompanied by the formation of many by-products. The 2,3-aziridino-gamma-Iactones were then used to synthesize APTO, a polysubstituted beta-amino acid fragment of microsclerodermines C and D. An enantiospecific synthesis of a cyclic precursor of APTO was developed starting from L-gulose. This strategy is based upon the preparation of the appropriate aziridine-Iactone, followed by regioselective CC2 ring-opening by an acetate and a Heck reaction. This intermediate was successfully opened by various amines, demonstrating its synthetic potential. Lastly, a new process for the preparation of 2,3-aziridino-gamma-Iactones starting from an unsaturated sulfamate was studied. This intramolecular nitrene transfer aziridination was catalyzed by rhodium salts and mediated by iodosylbenzene diacetate. This new methodology allowed the preparation of 2,3-aziridino-gamma-Iactones with a different stereochemistry than those synthesized previously, potentially leading to new beta-amino acids
Mähl, Philipp Henning. "Die Proteinkinase A-vermittelte Ekto-Phosphorylierung des Membranproteins FAT/CD36 hemmt die Aufnahme freier Palmitinsäure durch humane Thrombozyten." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2003. http://dx.doi.org/10.18452/14956.
Повний текст джерелаWe investigated the correlation between the ecto-protein kinase A-mediated phosphorylation of the membrane-associated protein FAT/CD36 [Hatmi et al. 1996] and the initial cellular long chain fatty acid uptake. Under the conditions of FAT/CD36-ecto-phosphorylation, an inhibitory effect on the initial palmitate uptake of human platelets could be shown. This is the first time that a mechanism for the short-term regulation of protein-mediated long chain fatty acid uptake can be proposed. The isolation of morphologically and functionally intact resting human platelets and a method for measuring the initial palmitate uptake were established. The kinetics of palmitate uptake by human platelets were characterised and it was shown that a substantial fraction of initial palmitate uptake is protein-mediated. The ecto-protein kinase A-mediated, cAMP-dependent phosphorylation of FAT/CD36 as described by Hatmi and co-authors could be demonstrated under our experimental conditions. The ecto-phosphorylation of FAT/CD36 was paralleled by a significant impairment of the initial palmitate uptake. Maximum inhibition was achieved at 0,5 nM extracellular ATP, when the palmitate uptake was decreased to 72 % compared to control. The inhibition of palmitate uptake was abolished by co-incubation with the specific protein kinase A inhibitor peptide PKI 5-24 or with beta-gamma-methylene-ATP, and was fully reversible upon addition of alkaline phosphatase. The inhibitory effect of the ecto-phosphorylation on the initial palmitate uptake was significant at extracellular ATP concentrations between 10 pM and 15 nM. ATP concentrations over 15 nM reduced the effect and concentrations over 5 µM completely abolished it. We could exclude that the abolishment was caused by ATP-derivates. Our data point to a regulatory influence of higher ATP concentrations, that antagonises the inhibitory effect of the ecto-phosphorylation of FAT/CD36 on the initial palmitate uptake.
BLANC, DELPHINE. "Hydrogenation asymetrique catalysee par des complexes chiraux du ruthenium : synthese de ligands chiraux a partir de diols 1,3 optiquement purs. synthese asymetrique de gamma-butyrolactones-alpha, beta, gamma-trisubstituees : (-)-methylenelactocine, acide (-)-phaseolinique et (-)-isoavenaciolide." Paris 6, 1999. http://www.theses.fr/1999PA066062.
Повний текст джерелаWan, Yang. "Synthesis of β,γ-diamino acids and their use to design new analogues of the antimicrobial peptide Gramicidin Septide antimicrobien, la Gramicidine S". Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS407/document.
Повний текст джерелаIn our group, we are interested in developing peptides containing β,γ-diamino acids . Along with many other peptides containing unnatural amino acids, they have shown the ability to possess stable conformations and/or interesting biological activities. Moreover, those peptides are usually more resistant to proteolysis. In order to synthesize stereopure γ-amino acids, we have developed a synthetic route using Blaise reaction and subsequent diastereoselective reduction as key reactions. Through applying this method, we have synthesized β,γ-diamino acids derived from D-phenylalanine and L-glutamic acid. The former β,γ-diamino acid was used for designing antimicrobial peptide gramicidin S analogues. Compared with mother molecule, the analogues exerted much less host cell cytotoxicity while remaining interesting antibacterial activity. Meanwhile, it gave us more knowledge for further developing analogues of gramicidin S as well as other antimicrobial peptides. We also paid lots of effort to efficiently synthesize cyclic β,γ-diamino acids starting from L-glutamic acid. Interestingly, when oligomers incorporating this β,γ-diamino acids and α-amino acids, they have shown the potential to adopt stable conformations. The following studies will be continuously investigated
Pimentel, Neusa Maria Nascimento. "Avaliação da resposta imuno-inflamatória no tecido cerebral de camundongos deficientes em CRAMP submetidos a modelo de etilismo agudo." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-28092018-092046/.
Повний текст джерелаThe use of alcohol is increasing in our society and remains associated with countless social, economic and health problems. In fact, alcohol and the health issues associated to its abuse exert an important impact on medical practice and represent one of the biggest challenges of public health. The consumption of alcohol in contemporary society is generally accepted positively, making certain patterns of consumption very difficult to be recognized as a disease. Alcoholism is a chronic relapsing disorder characterized by compulsive ingestion of excessive amounts of ethanol, loss of control in its intake, inappropriated behavior and the presence of a negative emotional state. The consumption of harmful amounts of alcohol results in physical and or psychological damage and addiction is a psychiatric disorder that affects the executive functions, causing loss of interest in other aspects of life and a compulsive behavior. Alcohol interacts with several neurologic systems. The present work analyzed the immuno-inflammatory response in the brain tissue of young CRAMP knockout (KO) and wild-type (WT) mice submitted to a model of alcohol intoxication, in order to investigate the impact of CRAMP in teenager alcohol addiction. CRAMP is an antimicrobial peptide with pleotropic effects and, as far as we know, its role had never been investigation in this regard. We also analysed the secretion of several neuropeptides, proteins and cytokines. Our results showed a significant difference in ethanol intake when CRAMP KO and WT animals were compared, which was related to an increase in the cerebellar levels of IL-1beta. We conclude that antimicrobial peptides may play an important role in the immunoinflammatory response that occurs during acute alcoholism
Книги з теми "Gamma-ammino acidi beta,beta-disostituiti"
1946-, Stephens David N., ed. Anxiolytic [Beta]-carbolines: From molecular biology to the clinic. Berlin: Springer-Verlag, 1993.
Знайти повний текст джерелаEllis, G. P., and G. B. West. Progress in medicinal chemistry. Amsterdam: Elsevier, 1985.
Знайти повний текст джерелаЧастини книг з теми "Gamma-ammino acidi beta,beta-disostituiti"
Pearl, Phillip L., and Lance Rodan. "Disorders of Beta and Gamma Amino Acids." In Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, 433–52. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-67727-5_24.
Повний текст джерелаBrown, Robert Andrew. "The Crucial Relevance of ALA and LA as Primary Peroxisomal Beta-Oxidation Substrates, of Oxidised LA as the Primary Endogenous Activator of PPAR Gamma, and Energy Deficit as the Primary Activator of PPAR Alpha." In Omega-3 Fatty Acids, 451–63. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40458-5_32.
Повний текст джерелаDuvnjak, Marija, Kristina Kljak, and Darko Grbeša. "Nitrogen Storage in Crops: Case Study of Zeins in Maize." In Nitrogen in Agriculture - Physiological, Agricultural and Ecological Aspects [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95380.
Повний текст джерелаТези доповідей конференцій з теми "Gamma-ammino acidi beta,beta-disostituiti"
Plow, E. F., G. A. Marguerie, and M. H. Ginsberg. "RECOGNITION SPECIFICITY OFADHESION RECEPTORS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643728.
Повний текст джерелаDampf, Sara J., and Timothy M. Korter. "Low-frequency Vibrational Spectroscopy of $\gamma$-Aminobutyric Acid Derivatives: GABA Hydrochloride and $\beta$-Phenyl-GABA Hydrochloride." In 2020 45th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz). IEEE, 2020. http://dx.doi.org/10.1109/irmmw-thz46771.2020.9370844.
Повний текст джерелаLara-Robustillo, Esperanza, and Marina Rodri´guez Alcala´. "Comparison of Actinides Separation by Coprecipitation and Chromatographic Resin (Dipex®) for Gross Alpha Determination." In ASME 2009 12th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2009. http://dx.doi.org/10.1115/icem2009-16249.
Повний текст джерелаCampodónico, Paola B., Andrea Motter, Eduardo F. Farias, Elisa D. Bal de Kier Joffé, and Laura B. Todaro. "Abstract 339: Importance of retinoic acid receptors alpha, beta and gamma on thein vivotumor growth of a murine mammary bi-cellular tumor cell line: Differential response of luminal and myoepithelial components to retinoids treatment." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-339.
Повний текст джерелаDenton, Mark S., and Mercouri G. Kanatzidis. "Innovative Highly Selective Removal of Cesium and Strontium Utilizing a Newly Developed Class of Inorganic Ion Specific Media." In ASME 2009 12th International Conference on Environmental Remediation and Radioactive Waste Management. ASMEDC, 2009. http://dx.doi.org/10.1115/icem2009-16221.
Повний текст джерела