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Статті в журналах з теми "G quadruplex binding ligand"
Neidle, Stephen. "Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids." Pharmaceuticals 15, no. 1 (December 22, 2021): 7. http://dx.doi.org/10.3390/ph15010007.
Повний текст джерелаOblak, Domen, San Hadži, Črtomir Podlipnik, and Jurij Lah. "Binding-Induced Diversity of a Human Telomeric G-Quadruplex Stability Phase Space." Pharmaceuticals 15, no. 9 (September 15, 2022): 1150. http://dx.doi.org/10.3390/ph15091150.
Повний текст джерелаSantos, Tiago, Gilmar F. Salgado, Eurico J. Cabrita, and Carla Cruz. "G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions." Pharmaceuticals 14, no. 8 (August 5, 2021): 769. http://dx.doi.org/10.3390/ph14080769.
Повний текст джерелаNowak-Karnowska, Joanna, Agata Głuszyńska, Joanna Kosman, Grażyna Neunert, and Anna Dembska. "Interaction of 9-Methoxyluminarine with Different G-Quadruplex Topologies: Fluorescence and Circular Dichroism Studies." International Journal of Molecular Sciences 22, no. 19 (September 27, 2021): 10399. http://dx.doi.org/10.3390/ijms221910399.
Повний текст джерелаHasegawa, Hijiri, Ikkei Sasaki, Kaori Tsukakoshi, Yue Ma, Kazuo Nagasawa, Shusuke Numata, Yuuki Inoue, Yeji Kim, and Kazunori Ikebukuro. "Detection of CpG Methylation in G-Quadruplex Forming Sequences Using G-Quadruplex Ligands." International Journal of Molecular Sciences 22, no. 23 (December 6, 2021): 13159. http://dx.doi.org/10.3390/ijms222313159.
Повний текст джерелаGłuszyńska, Agata, Bernard Juskowiak, and Błażej Rubiś. "Binding Study of the Fluorescent Carbazole Derivative with Human Telomeric G-Quadruplexes." Molecules 23, no. 12 (November 30, 2018): 3154. http://dx.doi.org/10.3390/molecules23123154.
Повний текст джерелаTsukakoshi, Kaori, Yuri Ikuta, Koichi Abe, Wataru Yoshida, Keisuke Iida, Yue Ma, Kazuo Nagasawa, Koji Sode, and Kazunori Ikebukuro. "Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers." Chemical Communications 52, no. 85 (2016): 12646–49. http://dx.doi.org/10.1039/c6cc07552e.
Повний текст джерелаBhadane, Rajendra, Rupali Bhadane, and Dhananjay Meshram. "Insights of potential G-quadruplex sequences in telomeres and proto-oncogenes." Archive of Oncology 21, no. 3-4 (2013): 118–24. http://dx.doi.org/10.2298/aoo1304118b.
Повний текст джерелаMoreira, David, Daniela Leitão, Jéssica Lopes-Nunes, Tiago Santos, Joana Figueiredo, André Miranda, Daniela Alexandre, Cândida Tomaz, Jean-Louis Mergny, and Carla Cruz. "G-Quadruplex Aptamer-Ligand Characterization." Molecules 27, no. 20 (October 11, 2022): 6781. http://dx.doi.org/10.3390/molecules27206781.
Повний текст джерелаDesai, Nakshi, Viraj Shah, and Bhaskar Datta. "Assessing G4-Binding Ligands In Vitro and in Cellulo Using Dimeric Carbocyanine Dye Displacement Assay." Molecules 26, no. 5 (March 5, 2021): 1400. http://dx.doi.org/10.3390/molecules26051400.
Повний текст джерелаДисертації з теми "G quadruplex binding ligand"
Marchand, Adrien. "Mass Spectrometry Study of G-Quadruplex Nucleic Acids : folding Pathways and Ligand Binding Modes." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0196/document.
Повний текст джерелаA G-quadruplex (G4) is a non-canonical nucleic acids structure formed by guanine-rich sequences. Some G4s are polymorphic, a given sequence can form G4s of different topologies. G4s are proposed to be biological regulators because they are found in key regions of the genome, for example, ingene promoters or at the telomeres. Stabilizing G4s formed in those regions as compared to the duplex form is a strategy to fight cancer. To do so, specific and affine ligands are used. Ligand design usually implies the optimization of large aromatic planes to π-π stack on external G-quartets. However, if this was the only binding mode, all ligands would bind with similar affinities to all G4s.To characterize which structures should be targeted and how the ligands interact with these structures, we used native mass spectrometry (MS).First, we developed a MS-compatible sample preparation method in KCl conditions in which G4s are folded with similar topologies as compared to those obtained in biologically relevant conditions. Then, we characterized the K+ binding equilibria and G4s folding pathways. This folding pathway involves the presence of a dead-end constituted by antiparallel G4s with either 1- or 2-K+ cations that are folded first. Finally, our ligand binding studies showed that some of the most affine ligands can influence G4’sstructures, as probed by the number of K+ ions bound. Ligands Phen-DC3, 360A and PDS are able to shift the equilibria towards the 1-K+ antiparallel G4s. The formation of antiparallel with 2-K+ complexes is induced by the cooperative binding of two Cu-ttpy ligands. Our results demonstrate the importance to characterize ternary complex stoichiometries (G4:ligand:K+) as obtained from native mass spectrometry
Bai, Liping. "The noncovalent binding of benzophenathridine alkaloids to double-stranded, bulged and G-quadruplex DNA." HKBU Institutional Repository, 2008. http://repository.hkbu.edu.hk/etd_ra/910.
Повний текст джерелаBright, Lois Eleanor. "Ligands and complexes for non-covalent binding to G-quadruplex DNA structures." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7457/.
Повний текст джерелаPipier, Angélique. "Etudes des G-quadruplexes : impact de la stabilisation par des ligands en tant qu'agents anti-cancéreux et identification des protéines associées régulant leur métabolisme." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30118.
Повний текст джерелаG-quadruplexes (or G4) are non-canonical structures of nucleic acid formed from guanine-rich sequences. G4 are stable structures, present throughout the genome and could be folded into different conformations. G4 formation can regulate, positively or negatively, different cellular processes such as transcription, replication, RNA transactions and mitochondrial mechanisms. All these processes require the recruitment of proteins able to modulate the formation of these structures. Indeed, some proteins, such as BLM, WRN or DHX36 helicases, are able to unwind G4 while others, like nucleolin (NCL), bind to and stabilize G4. Finally, G4 ligands, small molecules stabilizing G4, can impact various processes in which G4 are involved; in particular, they can cause repression of oncogene expression and lead to genomic instability. Thus, G4 ligands are considered to be potential anti-cancer agents. My thesis work focuses on several issues concerning G4: 1/ the improvement of G4 ligands and their characterization; 2/ the deciphering of the mechanisms inducing genomic instability following G4 stabilization by ligands; 3/ the identification of proteins able to bind to G4 (or GBPs for "G4 Binding Proteins"). Through biochemical and biophysical experiments, I have participated in the characterization of porphyrin-derived ligands. In the case of the AuMA ligand, I showed an increase in both G4 stabilization capacity and G4 specificity, compared to other porphyrin-derived molecules. This molecule therefore represents a better therapeutic potential than TMPyP4, a widely characterized ligand from which it is derived. I have also studied the genomic instability due to G4 stabilization using the pyridostatin ligand and the CX5461 ligand, currently in Phase II of a clinical trial. These ligands induce DNA double-strand breaks (or DSBs) dependent on transcription by RNA polymerase II and partly due to the transcriptional pausing. DSBs are initiated by the activity of Topoisomerases II, enzymes involved in the resolution of DNA topological stresses due to transcription and replication. These results show the significant role of transcription in the induction of genomic instability and open up new therapeutic approaches in the treatment of cancers in which these proteins are overexpressed or by combining them with other chemotherapies such as etoposide to increase their cytotoxic potential. I have studied G4-binding proteins using constrained structures, blocked in a particular conformation, by developing a protocol for the detection of GBPs through Pull-Down experiments followed by mass spectrometry analysis. These results, validated by the binding to G4 of proteins already identified and characterized such as WRN, DHX36 or CNBP, allow the identification of 425 GBP. Thus, I have highlighted new GBPs involved in various cellular processes such as replication, DNA repair, transcription and RNA metabolism. Aside, the study of CNBP protein in a zebrafish model has shown that the regulation of G4 in vivo affects transcription and embryonic development, reinforcing the role of G4 in whole living organisms. My work contributes to extend the knowledge of G4 and their ligands, particularly the mechanisms of action of G4 during transcription, and is opening up new therapeutic perspectives
Schouten, James Alexander. "Probing selective G-quadruplex binding using peptide motifs." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620018.
Повний текст джерелаKerkour, Abdelaziz. "Study of DNA G-quadruplex structures by Nuclear Magnetic Resonance (NMR)." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0292/document.
Повний текст джерелаG-quadruplexes (G4) are non-canonical nucleic acid structures formed by G-rich sequences mainly localized in telomeres and promoter regions of oncogenes. They are built from the stacking of several G-quartets in the presence of cations. Using NMR spectroscopy, we have characterized the interaction between the TAP ligand and the human telomeric G4 formed by the sequence d(AG3(T2AG3)3). CD and 1D 1H NMR spectroscopy were used to follow the interaction between the two partners. 2D NMR was used to assign unambiguously all 1H resonances in the complex and to explore the binding site. A model depicting the interaction of TAP with 22AG in grooves and loops was generated. Another part of this work consists in the study of tetramolecular G4 formed by TG4T and its interaction with G4 ligands by in-cell NMR. 1H-15N HMQC spectra were performed inside Xenopus laevis and HeLa cell lysates compared to those observed in vitro conditions showing a good stability of G4 inside the cell. Furthermore, the interaction of d[TG4T]4 with three G4 specific ligands presenting different mode of interaction was also investigated. The ligand 360A showed a promising behavior. Finally, in the last part, different sequences of Kras promoter were screened by NMR to select good candidates for high resolution structure determination. Two different sequences were selected and characterized by CD spectroscopy. The stabilization of G4 structures formed by these sequences in interaction with different ligands was also investigated. A 1D 1H NMR titration between Braco19 and 22RT showed an interesting behavior of k-ras G4 by the formation of intermediate species upon the addition of Braco19
Campbell, Nancy Husni. "Crystallographic and Molecular Modelling Studies of G-Quadruplex-Ligand complexes." Thesis, University College London (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515056.
Повний текст джерелаKoirala, Deepak P. "Mechanochemistry, Transition Dynamics and Ligand-Induced Stabilization of Human Telomeric G-Quadruplexes at Single-Molecule Level." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1397919270.
Повний текст джерелаQin, Yong. "Targeting the Promoter Regions of PDGF Ligand and Receptor." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/194387.
Повний текст джерелаPatel, Sachin Dinesh. "Studies on a designed G-quadruplex binding protein that inhibits human telomerase." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620939.
Повний текст джерелаКниги з теми "G quadruplex binding ligand"
Affinity and Efficacy. World Scientific Publishing Company, 2011.
Знайти повний текст джерелаMason, Peggy. Receiving the Synaptic Message. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0013.
Повний текст джерелаЧастини книг з теми "G quadruplex binding ligand"
Giancola, Concetta, and Bruno Pagano. "Energetics of Ligand Binding to G-Quadruplexes." In Topics in Current Chemistry, 211–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/128_2012_347.
Повний текст джерелаAsamitsu, Sefan. "Simultaneous Binding of Hybrid Molecules Constructed with Dual DNA-Binding Components to a G-Quadruplex and Its Proximal Duplex." In Development of Selective DNA-Interacting Ligands, 85–109. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-7716-1_4.
Повний текст джерелаDeng, Nanjie. "Using Molecular Dynamics Free Energy Simulation to Compute Binding Affinities of DNA G-Quadruplex Ligands." In Methods in Molecular Biology, 177–99. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9666-7_10.
Повний текст джерелаDettler, Jamie M., and Edwin A. Lewis. "Biophysical Studies of the Structure, Stability, and Ligand Binding Properties of G-Quadruplex DNA: Thoughts and Comparisons of the K-ras, c-MYC, and Bcl-2 Oncogene Promoter Sequence Quadruplexes." In ACS Symposium Series, 33–50. Washington, DC: American Chemical Society, 2011. http://dx.doi.org/10.1021/bk-2011-1082.ch003.
Повний текст джерелаOyoshi, Takanori. "Characterization of G-Quadruplex DNA- and RNA-Binding Protein." In Long Noncoding RNAs, 57–65. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55576-6_4.
Повний текст джерелаHaider, Shozeb, and Stephen Neidle. "Molecular Modeling and Simulation of G-Quadruplexes and Quadruplex-Ligand Complexes." In Methods in Molecular Biology, 17–37. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-363-9_2.
Повний текст джерелаLee, Chun-Ying, Christina McNerney, and Sua Myong. "G-Quadruplex and Protein Binding by Single-Molecule FRET Microscopy." In Methods in Molecular Biology, 309–22. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9666-7_18.
Повний текст джерелаSimon, Philipp, Philipp Schult, and Katrin Paeschke. "Binding and Modulation of G-quadruplex DNA and RNA Structures by Proteins." In Handbook of Chemical Biology of Nucleic Acids, 1–24. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-1313-5_102-1.
Повний текст джерелаDean, William L., Robert D. Gray, Lynn DeLeeuw, Robert C. Monsen, and Jonathan B. Chaires. "Putting a New Spin of G-Quadruplex Structure and Binding by Analytical Ultracentrifugation." In Methods in Molecular Biology, 87–103. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9666-7_5.
Повний текст джерелаLee, Hui Sun, and Wonpil Im. "G-LoSA for Prediction of Protein-Ligand Binding Sites and Structures." In Methods in Molecular Biology, 97–108. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7015-5_8.
Повний текст джерелаТези доповідей конференцій з теми "G quadruplex binding ligand"
Oliviero, Giorgia, Jussara Amato, Stefano D'Errico, Gennaro Piccialli, Patrick Mailliet, Frédéric Rosu, Edwin De Pauw, and Valérie Gabelica. "Ligand binding to tetra-end-linked (TGGGGT)4 G-quadruplexes: an electrospray mass spectrometry study." In XIVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810333.
Повний текст джерелаMorel, Elodie, Florence Mahuteau-Betzer, Florian Hamon, Corinne Guetta, and Marie-Paule Teulade-Fichou. "Exploration of metal terpyridine complexes for G-quadruplex DNA binding." In XVIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414328.
Повний текст джерелаLin, Clement, Guanhui Wu, Kaibo Wang, Buket Onel, Saburo Sakai, and Danzhou Yang. "Abstract 1856: Targeting human telomeres by binding of epiberberine to telomeric G-quadruplex." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-1856.
Повний текст джерелаLin, Clement, Guanhui Wu, Kaibo Wang, Buket Onel, Saburo Sakai, and Danzhou Yang. "Abstract 1856: Targeting human telomeres by binding of epiberberine to telomeric G-quadruplex." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-1856.
Повний текст джерелаFolini, Marco, Nicola I. Orlotti, Graziella Cimino-Reale, Erika Borghini, Maria Grazia Daidone, Manlio Palumbo, Claudia Sissi, and Nadia Zaffaroni. "Abstract A26: Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated telomere damage." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-a26.
Повний текст джерелаCobanoglu, Murat Can, Ugur Sezerman, and Nermin Pinar Karabulut. "Determinig the ligand-specific regions of peptide-binding G-Protein Coupled Receptors." In 2010 5th International Symposium on Health Informatics and Bioinformatics. IEEE, 2010. http://dx.doi.org/10.1109/hibit.2010.5478880.
Повний текст джерелаBabakuliyev, Alisir, Niladri Maiti, Annie Aglin Antony, Mohammad Javed Ansari, Santosh S. Chobe, and Chandra Kumar Dixit. "Detection of Cancer Cells Using G-Rich DNA Based Target Binding-Switching Calorimetric Biosensor." In International Conference on Recent Advancements in Biomedical Engineering. Switzerland: Trans Tech Publications Ltd, 2022. http://dx.doi.org/10.4028/p-3o604e.
Повний текст джерелаPorru, Manuela, Simona Artuso, Luca Pompili, Carla Caruso, Armandodoriano Bianco, Marcella Mottolese, Carla A. Amoreo, Annamaria Biroccio, and Carlo Leonetti. "Abstract 266: The G-quadruplex ligand EMICORON potentiates the antitumor efficacy of chemotherapy on colon cancer experimental models." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-266.
Повний текст джерелаMiyazaki, Takeshi, Yang Pan, Bin Hu, Habibe Demir, Kaushal Joshi, Sachiko Okabe, Takao Yamori, et al. "Abstract 3302: The effects of the g-quadruplex ligand telomestatin to human brain tumor stem cell survival and growth." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3302.
Повний текст джерелаBeauvarlet, J., P. Ben Sadoun, G. Labrunie, RN Das, E. Richard, B. Rousseau, E. Darbo, S. Croce, JL Mergny, and M. Djavaheri-Mergny. "PO-446 Anti-tumour efficiency of 20A, a novel G-quadruplex ligand, inin vitroandin vivocancer models: ATM and autophagy interplay." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.469.
Повний текст джерелаЗвіти організацій з теми "G quadruplex binding ligand"
Ebbinghaus, Scot W. Evaluation of the G-quadruplex Binding Drug Telomestatin as an Inhibitor of c-myb in Chronic Myelogenous Leukemia. Fort Belvoir, VA: Defense Technical Information Center, February 2007. http://dx.doi.org/10.21236/ada587004.
Повний текст джерелаEbbinghaus, Scot W. Evaluation of the G-quadruplex Binding Drug Telomestatin as an Inhibitor of c-myb in Chronic Myelogenous Leukemia. Fort Belvoir, VA: Defense Technical Information Center, February 2007. http://dx.doi.org/10.21236/ada593319.
Повний текст джерелаRafaeli, Ada, and Russell Jurenka. Molecular Characterization of PBAN G-protein Coupled Receptors in Moth Pest Species: Design of Antagonists. United States Department of Agriculture, December 2012. http://dx.doi.org/10.32747/2012.7593390.bard.
Повний текст джерела