Готові списки джерел за темами / Frontostriatal

Добірка наукової літератури з теми "Frontostriatal"

Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 28 січня 2023

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Статті в журналах з теми "Frontostriatal"

1

Mori, Asako, Yasumasa Okamoto, Go Okada, Koki Takagaki, Masahiro Takamura, Ran Jinnin, Naho Ichikawa, et al. "Effects of behavioural activation on the neural circuit related to intrinsic motivation." BJPsych Open 4, no. 5 (August 2, 2018): 317–23. http://dx.doi.org/10.1192/bjo.2018.40.

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BackgroundBehavioural activation is an efficient treatment for depression and can improve intrinsic motivation. Previous studies have revealed that the frontostriatal circuit is involved in intrinsic motivation; however, there are no data on how behavioural activation affects the frontostriatal circuit.AimsWe aimed to investigate behavioural activation-related changes in the frontostriatal circuit.MethodFifty-nine individuals with subthreshold depression were randomly assigned to either the intervention or non-intervention group. The intervention group received five weekly behavioural activation sessions. The participants underwent functional magnetic resonance imaging scanning on two separate occasions while performing a stopwatch task based on intrinsic motivation. We investigated changes in neural activity and functional connectivity after behavioural activation.ResultsAfter behavioural activation, the intervention group had increased activation and connectivity in the frontostriatal region compared with the non-intervention group. The increased activation in the right middle frontal gyrus was correlated with an improvement of subjective sensitivity to environmental rewards.ConclusionsBehavioural activation-related changes to the frontostriatal circuit advance our understanding of psychotherapy-induced improvements in the neural basis of intrinsic motivation.Declaration of interestNone.
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Shang, C. Y., Y. H. Wu, S. S. Gau, and W. Y. Tseng. "Disturbed microstructural integrity of the frontostriatal fiber pathways and executive dysfunction in children with attention deficit hyperactivity disorder." Psychological Medicine 43, no. 5 (August 15, 2012): 1093–107. http://dx.doi.org/10.1017/s0033291712001869.

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BackgroundAttention deficit hyperactivity disorder (ADHD) is recognized as an early-onset neuropsychiatric disorder with executive dysfunctions and neurobiological deficits. The authors compared executive functions and microstructural integrity of the frontostriatal circuit in children with ADHD and typically developing children.MethodWe assessed 25 children with ADHD and 25 age-, sex-, handedness- and intelligence-matched typically developing children by using psychiatric interviews, the Wechsler Intelligence Scale for Children – third edition, and the tasks involving executive functions in the Cambridge Neuropsychological Test Automated Battery. The frontostriatal tracts were reconstructed by diffusion spectrum imaging tractography and were subdivided into four functionally distinct segments, including dorsolateral, medial prefrontal, orbitofrontal and ventrolateral tracts. Tract-specific and matched case-control analyses were used and generalized fractional anisotropy values were computed.ResultsChildren with ADHD had lower generalized fractional anisotropy of all the bilateral frontostriatal fiber tracts and poorer performance in verbal and spatial working memory, set-shifting, sustained attention, cognitive inhibition and visuospatial planning. The symptom severity of ADHD and the executive functioning performance significantly correlated with integrity of the frontostriatal tracts, particularly the left orbitofrontal and ventrolateral tracts. Children with ADHD also demonstrated loss of the leftward asymmetry in the dorsolateral and medial prefrontal tracts that was present in typically developing children.ConclusionsOur findings demonstrate disturbed structural connectivity of the frontostriatal circuitry in children with ADHD and add new evidence of associations between integrity of the frontostriatal tracts and measures of core symptoms of ADHD and a wide range of executive dysfunctions in both groups.
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Gau, S. S., W. L. Tseng, W. Y. I. Tseng, Y. H. Wu, and Y. C. Lo. "Association between microstructural integrity of frontostriatal tracts and school functioning: ADHD symptoms and executive function as mediators." Psychological Medicine 45, no. 3 (July 28, 2014): 529–43. http://dx.doi.org/10.1017/s0033291714001664.

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BackgroundDeficits in executive function (EF), impaired school functioning and altered white matter integrity in frontostriatal networks have been associated with attention-deficit/hyperactivity disorder (ADHD). However, relationships between impairments in these areas are unclear. Using a sample of youths with and without ADHD, this study examined the association between microstructural integrity of frontostriatal tracts and school dysfunction and the mediating roles of EF and ADHD symptoms in this association.MethodThe sample included 32 Taiwanese youths with ADHD and 32 age-, sex-, handedness- and IQ-matched typically-developing (TD) youths. Participants were assessed using psychiatric interviews, parent reports on ADHD symptoms and school functioning, and EF measures from the Cambridge Neuropsychological Test Automated Battery (CANTAB). The frontostriatal tracts were reconstructed by diffusion spectrum imaging (DSI) tractography and were subdivided into four functionally distinct segments: caudate–dorsolateral, caudate–medial prefrontal, caudate–orbitofrontal and caudate–ventrolateral tracts.ResultsYouths with ADHD, relative to TD youths, showed altered white matter integrity in all four bilateral pairs of frontostriatal tracts (decreased general fractional anisotropy, GFA), had poor attention, vigilance and response inhibition, and showed impaired school functioning. Altered microstructural integrity in frontostriatal tracts was significantly associated with school dysfunction, which was mediated by EF measures of attention/vigilance and response inhibition in addition to inattention and hyperactivity symptoms.ConclusionsOur findings demonstrate an association between white matter integrity in the frontostriatal networks and school functioning and suggest that EF deficits and ADHD symptoms may be the mediating mechanisms for this association. Future research is needed to test the directionality and specificity of this finding.
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Ipser, Jonathan C., Gregory G. Brown, Amanda Bischoff-Grethe, Colm G. Connolly, Ronald J. Ellis, Robert K. Heaton, and Igor Grant. "HIV Infection Is Associated with Attenuated Frontostriatal Intrinsic Connectivity: A Preliminary Study." Journal of the International Neuropsychological Society 21, no. 3 (March 2015): 203–13. http://dx.doi.org/10.1017/s1355617715000156.

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AbstractHIV-associated cognitive impairments are prevalent, and are consistent with injury to both frontal cortical and subcortical regions of the brain. The current study aimed to assess the association of HIV infection with functional connections within the frontostriatal network, circuitry hypothesized to be highly vulnerable to HIV infection. Fifteen HIV-positive and 15 demographically matched control participants underwent 6 min of resting-state functional magnetic resonance imaging (RS-fMRI). Multivariate group comparisons of age-adjusted estimates of connectivity within the frontostriatal network were derived from BOLD data for dorsolateral prefrontal cortex (DLPFC), dorsal caudate and mediodorsal thalamic regions of interest. Whole-brain comparisons of group differences in frontostriatal connectivity were conducted, as were pairwise tests of connectivity associations with measures of global cognitive functioning and clinical and immunological characteristics (nadir and current CD4 count, duration of HIV infection, plasma HIV RNA). HIV – associated reductions in connectivity were observed between the DLPFC and the dorsal caudate, particularly in younger participants (<50 years, N=9). Seropositive participants also demonstrated reductions in dorsal caudate connectivity to frontal and parietal brain regions previously demonstrated to be functionally connected to the DLPFC. Cognitive impairment, but none of the assessed clinical/immunological variables, was also associated with reduced frontostriatal connectivity. In conclusion, our data indicate that HIV is associated with attenuated intrinsic frontostriatal connectivity. Intrinsic connectivity of this network may therefore serve as a marker of the deleterious effects of HIV infection on the brain, possibly via HIV-associated dopaminergic abnormalities. These findings warrant independent replication in larger studies. (JINS, 2015, 21, 1–11)
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Becker, Alena, Martin Fungisai Gerchen, Martina Kirsch, Bettina Ubl, Sivaniya Subramaniapillai, Carsten Diener, Christine Kuehner, Falk Kiefer, and Peter Kirsch. "Frontostriatal Connectivity During Reward Anticipation." Zeitschrift für Psychologie 225, no. 3 (July 2017): 232–43. http://dx.doi.org/10.1027/2151-2604/a000307.

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Abstract. Neurobiological research indicates that altered reward processing is among the most promising risk mechanisms in alcohol use disorder and depression. To elucidate differences and similarities between both disorders, we investigated clinical patients and at-risk individuals in two studies using a functional magnetic resonance imaging (fMRI) monetary reward paradigm. In the first study, alcohol use disorder patients compared to depressed and healthy individuals showed increased activation of the ventral striatum during reward anticipation. In contrast, both patient groups showed reduced frontostriatal connectivity compared to controls. In the second study, at-risk comorbid individuals showed decreased activation in the dorsal striatum along with decreased frontostriatal connectivity. While the connectivity results replicate the common pattern found for the patient groups, the activation results indicate a more depression-related pattern in individuals prone to developing both disorders. In conclusion, frontostriatal connectivity might be a promising transdiagnostic marker for depression, alcohol use disorder, and their comorbidity.
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Radakovic, Ratko, Vaisakh Puthusseryppady, Emma Flanagan, Matthew C. Kiernan, Eneida Mioshi, and Michael Hornberger. "Frontostriatal grey matter atrophy in amyotrophic lateral sclerosis A visual rating study." Dementia & Neuropsychologia 12, no. 4 (December 2018): 388–93. http://dx.doi.org/10.1590/1980-57642018dn12-040008.

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ABSTRACT Amyotrophic lateral sclerosis (ALS) is characterised by frontostriatal grey matter changes similar to those in frontotemporal dementia (FTD). However, these changes are usually detected at a group level, and simple visual magnetic resonance imaging (MRI) cortical atrophy scales may further elucidate frontostriatal changes in ALS. Objective: To investigate whether frontostriatal changes are detectable using simple visual MRI atrophy rating scales applied at an individual patient level in ALS. Methods: 21 ALS patients and 17 controls were recruited and underwent an MRI scan. Prefrontal cortex sub-regions of the medial orbitofrontal cortex (MOFC), lateral orbitofrontal cortex (LOFC) and anterior cingulate cortex (ACC), striatal sub-regions of the caudate nucleus (CN) and nucleus accumbens (NAcc) were rated using visual grey matter atrophy 5-point Likert scales. Results: Significantly higher atrophy ratings in the bilateral MOFC only in ALS patients versus controls was observed (p<.05). Patients with greater MOFC atrophy had significantly higher atrophy of the CN (p<.05) and LOFC (p<.05). Conclusion: Use of simple visual atrophy rating scales on an individual level reliably detects frontostriatal deficits specific to ALS, showing MOFC atrophy differences with associated CN and LOFC atrophy. This is an applicable method that could be used to support clinical diagnosis and management.
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Levitt, James, Marek Kubicki, Robert McCarley, Martha Shenton, and Yogesh Rathi. "161. Frontostriatal Miswiring in Schizophrenia." Schizophrenia Bulletin 43, suppl_1 (March 1, 2017): S82. http://dx.doi.org/10.1093/schbul/sbx021.219.

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Sabaroedin, Kristina, Adeel Razi, Kevin Aquino, Sidhant Chopra, Amy Finlay, Barnaby Nelson, Kelly Allott, et al. "S166. EFFECTIVE CONNECTIVITY OF FRONTOSTRIATAL SYSTEMS IN FIRST-EPISODE PSYCHOSIS." Schizophrenia Bulletin 46, Supplement_1 (April 2020): S99—S100. http://dx.doi.org/10.1093/schbul/sbaa031.232.

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Abstract Background Neuroimaging studies have found dysconnectivity of frontostriatal circuits across a broad spectrum of psychotic symptoms. However, it is unknown whether dysconnectivity within frontostriatal circuits originates from disrupted bottom-up or top-down control signaling within these systems. Here, we used dynamic causal modelling (DCM) to examine the effective connectivity of frontostriatal systems in first-episode psychosis (FEP). Methods A total of 55 FEP patients (26 males; mean [SD] age = 19.24 [2.89]) and 24 healthy controls (15 males; mean [SD] age = 21.83 [1.93]) underwent a resting-state functional magnetic resonance imaging protocol. Biologically plausible connections between eight left hemisphere regions encompassing the dorsal and ventral frontostriatal systems were modelled using spectral DCM. The regions comprise dorsolateral prefrontal cortex, ventromedial prefrontal cortex, anterior hippocampus, amygdala, dorsal caudate, nucleus accumbens, thalamus, and the midbrain. Effective connectivity between groups were assessed using a parametric Bayesian model. Associations between effective connectivity parameters and positive symptoms, measured by the Brief Psychiatric Rating Scale positive subscale, was assessed in the patient group in a separate Bayesian general linear model. Results DCM shows evidence for differences in effective connectivity between patients and healthy controls, namely in the bottom-down connections distributed in the frontostriatal system encompassing the hippocampus, amygdala, striatum, and midbrain. Compared to healthy controls, patients also demonstrated increased disinhibition of the midbrain. In patients, positive symptoms are associated with increased top-down connections to the midbrain. Outgoing connection from the midbrain to the nucleus accumbens is also increased in association with positive symptoms. Discussion Aberrant top-down connectivity in the frontostriatal system in patients is consistent with top-down dysregulation of dopamine function in FEP, as dopaminergic activity in the midbrain is proposed to be under the control of higher brain areas. In patients, increased self-inhibition of the midbrain, as well as symptom associations in both ingoing and outgoing connections of this region, are congruous with hyperactivity of the midbrain as proposed by the dopamine dysregulation hypothesis. Here, we demonstrate that mathematical models of brain imaging signals can be used to identify the key disruptions driving brain circuit dysfunction, identifying new targets for treatment.
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Chen, Mu-Hong, Wan-Chen Chang, Wei-Chen Lin, Pei-Chi Tu, Cheng-Ta Li, Ya-Mei Bai, Shih-Jen Tsai, Wen-Sheng Huang, and Tung-Ping Su. "Functional Dysconnectivity of Frontal Cortex to Striatum Predicts Ketamine Infusion Response in Treatment-Resistant Depression." International Journal of Neuropsychopharmacology 23, no. 12 (July 30, 2020): 791–98. http://dx.doi.org/10.1093/ijnp/pyaa056.

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Abstract Background Frontostriatal disconnectivity plays a crucial role in the pathophysiology of major depressive disorder. However, whether the baseline functional connectivity of the frontostriatal network could predict the treatment outcome of low-dose ketamine infusion remains unknown. Methods In total, 48 patients with treatment-resistant depression were randomly divided into 3 treatment groups (a single-dose 40-minute i.v. infusion) as follows: 0.5 mg/kg ketamine, 0.2 mg/kg ketamine, and saline placebo infusion. Patients were subsequently followed-up for 2 weeks. Resting-state functional magnetic resonance imaging was performed for each patient before infusion administration. In addition, the baseline frontostriatal functional connectivity of patients with treatment-resistant depression was also compared with that of healthy controls. Results Compared with the healthy controls, patients with treatment-resistant depression had a decreased functional connectivity in the frontostriatal circuits, especially between the right superior frontal cortex and executive region of the striatum and between the right paracingulate cortex and rostral-motor region of the striatum. The baseline hypoconnectivity of the bilateral superior frontal cortex to the executive region of the striatum was associated with a greater reduction of depression symptoms after a single 0.2-mg/kg ketamine infusion. Conclusion Reduced connectivity of the superior frontal cortex to the striatum predicted the response to ketamine infusion among patients with treatment-resistant depression.
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Shukla, Dinesh K., Joshua John Chiappelli, Hemalatha Sampath, Peter Kochunov, Stephanie M. Hare, Krista Wisner, Laura M. Rowland, and L. Elliot Hong. "Aberrant Frontostriatal Connectivity in Negative Symptoms of Schizophrenia." Schizophrenia Bulletin 45, no. 5 (December 21, 2018): 1051–59. http://dx.doi.org/10.1093/schbul/sby165.

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AbstractNegative symptoms represent a distinct component of psychopathology in schizophrenia (SCZ) and are a stable construct over time. Although impaired frontostriatal connectivity has been frequently described in SCZ, its link with negative symptoms has not been carefully studied. We tested the hypothesis that frontostriatal connectivity at rest may be associated with the severity of negative symptoms in SCZ. Resting state functional connectivity (rsFC) data from 95 mostly medicated patients with SCZ and 139 healthy controls (HCs) were acquired. Negative symptoms were assessed using the Brief Negative Symptom Scale. The study analyzed voxel-wise rsFC between 9 frontal “seed regions” and the entire striatum, with the intention to reduce potential biases introduced by predefining any single frontal or striatal region. SCZ showed significantly reduced rsFC between the striatum and the right medial and lateral orbitofrontal cortex (OFC), lateral prefrontal cortex, and rostral anterior cingulate cortex compared with HCs. Further, rsFC between the striatum and the right medial OFC was significantly associated with negative symptom severity. The involved striatal regions were primarily at the ventral putamen. Our results support reduced frontostriatal functional connectivity in SCZ and implicate striatal connectivity with the right medial OFC in negative symptoms. This task-independent resting functional magnetic resonance imaging study showed that medial OFC–striatum functional connectivity is reduced in SCZ and associated with severity of negative symptoms. This finding supports a significant association between frontostriatal connectivity and negative symptoms and thus may provide a potential circuitry-level biomarker to study the neurobiological mechanisms of negative symptoms.
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Більше джерел

Дисертації з теми "Frontostriatal"

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Manohar, S. G. "Frontostriatal contributions to reward processing." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1470430/.

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Dopaminergic projections to striatum and prefrontal cortex are thought to signal rewards, thereby energising movement, facilitating learning, and motivating effort. Extensive evidence links reward to attention and to dopamine. However a direct characterisation of how dopamine influences reward sensitivity in humans is lacking. This thesis examines the effects of dopamine and reward on eye movements. First, I introduced incentive manipulations into an “oculomotor capture” task, in which involuntary saccades are generated towards salient distractors. Whereas rewards increased both speed and accuracy, penalties slowed responses while increasing accuracy. A previously unreported effect is described, in which missed rewards capture attention. Subsequently, I developed a new paradigm that manipulates incentives trial-to-trial, during a speeded saccadic distraction task. In healthy volunteers, reward reduced distractibility and increased vigour (in terms of reaction time and velocity), and pupillary dilatation reflected reward expectation. This new task was then employed in a pharmacological study, in which I found that the dopaminergic D2-selective agonist cabergoline increased reward sensitivity in healthy volunteers. Parkinson's disease (PD) results in dopamine deficiency. PD patients performing my task had reduced reward sensitivity in saccade velocity and distractibility, as well as pupil dilatation. Patients were compared on versus off their dopaminergic medication, and although oculomotor vigour did not improve, medication normalised their blunted autonomic responses. Finally, 20 patients with medial prefrontal damage following subarachnoid haemorrhage performed the oculomotor task. Using lesion mapping, I found specific medial orbitofrontal regions in which damage correlated with reduced reward sensitivity. The results demonstrate that the extent to which reward invigorates behaviour is influenced by dopamine. Importantly, reward improves both speed and accuracy, contravening the theoretically predicted trade-off. To resolve this paradox, I develop an extension of optimal control theory that includes a costly precision signal. This model helps conceptualise reward's power to improve both speed and accuracy.
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Scott, Ashley Anna. "Imaging genetics of frontostriatal function in autism spectrum disorders." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1872142711&sid=8&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Emmons, Eric Blockhus. "The role of frontostriatal circuits in basic cognitive processing." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6569.

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The ability to take in one’s environment, integrate relevant information, and then act appropriately is an incredibly complex feat that organisms do continuously. Disruption in the ability to think and act clearly, or cognitive dysfunction, is a debilitating aspect of neuropsychiatric diseases like schizophrenia. The prefrontal cortex and the striatum are key brain regions for functional and dysfunctional cognition, but the way that they interact to allow for cognitive processing is poorly understood. To get at these questions, I manipulated and recorded from medial frontal and striatal neurons—frontostriatal ensembles—while rats engaged in interval timing, an elementary cognitive function that engages both areas. I report four main results. First, ramping activity—a gradual, consistent change in neuronal firing rate across time—is observed throughout frontostriatal ensembles. Secondly, medial frontal areas dynamically reflect changing temporal conditions during learning and precede these same changes in striatal areas. Thirdly, interval timing and striatal ramping activity are disrupted when the medial frontal cortex is inactivated. Finally, this behavioral impairment can be reduced by optogenetic stimulation of frontostriatal terminals. My results support the view that striatal neurons integrate medial frontal activity and suggest a possible mechanism—ramping activity—through which neurons might represent the passage of time. These observations elucidate temporal processing in frontostriatal circuits and provide insight into how the medial frontal cortex exerts top-down control of cognitive processing in the striatum. My hope is that these findings will contribute to a clearer understanding of basic cognitive processing and might inform future approaches to treatments that address cognitive dysfunction.
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DeVito, Elise Eva. "Cognition in disorders of frontostriatal dysfunction : neuropsychological, neuroimaging and psychopharmacological studies." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611615.

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Kehagia, Angeliki. "Frontostriatal components of executive control in task set switching and rule-based behaviour." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612018.

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Stumpenhorst, Katharina. "Separate and interactive effects of catechol-o-methyltransferase and tetrahydrocannabinol on frontostriatal dopamine function." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:e8eb9eba-0e32-4b30-8349-c2678207f547.

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The frontostriatal dopamine system modulates brain function and is affected by both genetic and environmental factors. Dysfunction of this system is associated with many pathological states, including schizophrenia. The enzyme catechol-O- methyltransferase (COMT) metabolises dopamine and its gene contains a polymorphism (Val158Met) that affects enzyme activity. Delta-9- tetrahydrocannabinol (THC), the main psychoactive component of cannabis, has been suggested to interact with this polymorphism to increase the risk for psychosis and cognitive impairments. Dopaminergic mechanisms are a plausible candidate for mediating this interaction. I used microdialysis coupled with high performance liquid chromatography (HPLC) to examine the effects of THC on extracellular dopamine and its metabolites in the nucleus accumbens, dorsal striatum and medial prefrontal cortex (mPFC) in freely moving mice. Following acute COMT inhibition with tolcapone, THC increased extracellular dopamine levels in the nucleus accumbens in tolcapone-, but not in vehicle-, treated mice. The introduction of the low activity Met allele into the COMT gene produced a highly specific, novel mouse model of the Val158Met polymorphism. In contrast to the effects of acute COMT inhibition, the Met allele protected against THC-induced changes in accumbal dopamine. No interactive neurochemical effects were observed in the dorsal striatum (pharmacological and genetic study) or in a preliminary study of the mPFC (genetic study only). On a progressive ratio task measuring motivational salience, the direction of the interactive effect between COMT genotype and THC differed between 2 independent cohorts and provided tentative leads that stress/arousal-dependent effects on COMT may have a confounding effect. My data provide evidence that COMT activity modulates the effect of THC on accumbal dopamine function, and suggest the mechanism through which this interaction is mediated differs between acute and lifelong reduction in COMT activity. Through the interactive effect on the dopaminergic system, the data provide a potential mechanism for the reported interaction between COMT and cannabis/THC in determining psychosis risk and cognitive impairments.
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Hamann, Janne Marie [Verfasser], and Christian [Akademischer Betreuer] Gerloff. "Baseline frontostriatal-limbic connectivity predicts reward-based memory formation / Janne Marie Hamann ; Betreuer: Christian Gerloff." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2017. http://d-nb.info/1144485223/34.

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Cole, Robert David. "NICOTINE WITHDRAWAL AND DEFICITS IN COGNITIVE FLEXIBILITY: POSSIBLE TIES TO ABERRATIONS IN FRONTOSTRIATAL BDNF SIGNALING." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/426579.

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Анотація:
Psychology
Ph.D.
Nicotine addiction continues to be a leading cause of preventable death worldwide. Despite the plethora of available treatments for smoking cessation, smoking relapse after attempts to quit remains high. It is possible that impairments in cognitive flexibility and underlying neurochemical circuits in nicotine addicts may foster maladaptive behaviors that affect individuals’ ability to refrain from taking drugs. Here we characterized the effects of spontaneous nicotine withdrawal on cognitive flexibility in mice using an operant strategy set-shifting task. Because frontostriatal circuits are critical for cognitive flexibility and brain-derived neurotrophic factor (BDNF) modulates glutamate plasticity, we also explored the effects of nicotine withdrawal on these neurochemical substrates. Adult male C57BL/6J mice were trained in an operant task that required the animals to switch from using a spatial response-driven strategy to a visual cue-based strategy to achieve rewards. Mice were exp
Temple University--Theses
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Looi, Jeffrey Chee Leong. "Quantitative neostriatal neuroanatomy as a basis of frontostriatal circuit dysfunction in neuropsychiatric disease." Phd thesis, 2011. http://hdl.handle.net/1885/8757.

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Background and Purpose: Neuropsychiatric diseases are protean, affecting cognition, emotion and behaviour, including such diseases as reactions to traumatic stress (post-traumatic stress disorder), cerebrovascular disease and the neurodegenerative dementias. There has been much interest in understanding the neural basis of neuropsychiatric disease. A model that has been employed to investigate such disease has been the endophenotype, a restricted set of phenotypic or clinical features that may have a more specific structural and hence, genetic basis. An example of an endophenotype is frontal-executive neuropsychological function, localised to the neural substrate of dorsolateral prefrontal cortex frontostriatal circuit. Consequently, it is possible to explore the structural basis of an endophenotype by studying the components of neural circuits carrying such functions. Thus, frontostriatal circuits may be useful as a structural basis for endophenotypes related to frontal cognitive function. These circuits extensively mediate cognition, emotion and behaviour within humans. The caudate nucleus and putamen, comprising the human neostriatum, serve crucial roles within frontostriatal circuits. The caudate and putamen may thus serve as a potential, quantifiable component of the structural basis for endophenotypes. It was hypothesized that functional change may be reflected in structural changes in the neostriatum due to neuroplasticity. Thus functional activation or disconnection might impact upon the structure of the caudate or putamen. Other corticostriatal circuits in addition to frontostriatal circuits may thus be affected. These studies were designed to measure the volume of the neostriatum as a quantified neuroanatomical basis of the endophenotype of frontostriatal dysfunction within specific neuropsychiatric diseases. <...>
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Chen, Nai-Chi, and 陳乃綺. "Frontostriatal Activation Correlates of Interference Resolution in Task Switching and Age Differences." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/7q89yf.

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Анотація:
碩士
國立臺灣大學
腦與心智科學研究所
106
Background: Research showed that older adults have more difficulty than young adults with resolving interference from conflicting bivalent stimuli. This age difference could be more prominent when the relevance of stimulus features changes dynamically during task-switching. However, it remains unknown whether the middle-aged, who are in the important transitional stage of cognitive aging, would behave more similarly to the young or the older in their interference resolution ability during task-switching. Therefore, this study was aimed to investigate this effect behaviorally as well as the associated neural mechanisms, especially those pertaining to the frontostriatal activations, across cognitively normal young, middle-aged, and older adults. Methods: We used a hybrid event-related block design of functional magnetic resonance imaging (fMRI) experiment. Participants had to perform a modified numerical Stroop task in the non-switch and switch conditions. Cognitive intact young (n=35, age= 25.7 ± 4.2 years, 20.2 - 33.8 years), middle-aged (n=38, 59.1 ± 3.4 years, 52.0-63.5 years) and older adults (n=36, 70.4 ± 4.0 years, 65.4 - 80.1 years) were enrolled in this study. In each trial, participants were presented with digit pair stimuli of bivalent attributes (i.e., physical size and numerical value) and were instructed to compare two digits and make button response according to the relevant task-rule (the physical size discrimination or numerical value discrimination rule), which was cued by color of the digit stimuli. In the congruent trials, the correct responses would be the same according to either relevant or irrelevant rule, creating no interference effects. In the incongruent trials, the correct responses would be different according to the two rules, creating the interference effects. In the non-switch condition, the physical size and numerical size rule was tested in repeated trials of two separate blocks; in the switch condition, the rules changed pseudorandomly between trials in one block. The behavioral interference effects on accuracy and reaction time (RT) and brain activations related to interference effect were recorded and analyzed. Results & Discussion: Behaviorally, we found that the interference effect on accuracy was greater in the switch than in the non-switch condition, but there was no age difference in this interference effect between switch and non-switch conditions. Neuroimaging results revealed that during task-switching, the striatal activations for interference resolution gradually shifted from primarily the caudate in the young, to the caudate plus the putamen in the middle-aged, and to primarily the putamen in the older. In addition, while the bilateral inferior frontal gyri were significantly activated for interference resolution in the switch condition in the young and middle-aged, these two regions were not significantly activated in the same condition in the older adults. Correlation analyses between behavioral measures and brain activations showed that in the young adults, greater bilateral dorsal caudate activations were related to a smaller interference cost in behavioral accuracy, suggesting their successful use of top-down filtering mechanisms for early interference resolution; while in older adults, greater activation in the dorsal anterior cingulate was correlated with a smaller interference cost in accuracy, which may suggest their shift to rely on the salient network and interference resolving during response selection stage. Conclusions: Effective recruitment of the prefronto-dorsostriatal network might play an important role in successful suppression of irrelevant stimuli during task-switching in young and middle-aged adults. In contrast, older adults may rely on the salient network and sensorimotor striatum to achieve this task.
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Книги з теми "Frontostriatal"

1

Bradshaw, John L. Developmental disorders of the frontostriatal system: Neuropsychological, neuropsychiatric, and evolutionary perspectives. Philadelphia, PA: Psychology Press, 2001.

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2

Bradshaw, John L., and Peter G. Enticott, eds. Developmental Disorders of the Frontostriatal System. Psychology Press, 2014. http://dx.doi.org/10.4324/9781315782966.

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3

Bradshaw, John L., and Nicole Rinehart. Developmental Disorders of the Frontostriatal System: Neuropsychological, Neuropsychiatric and Evolutionary Perspectives. Taylor & Francis Group, 2014.

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4

Bradshaw, John L. Developmental Disorders of the Frontostriatal System: Neuropsychological, Neuropsychiatric and Evolutionary Perspectives. Taylor & Francis Group, 2014.

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5

Graat, Ilse, Martijn Figee, and Damiaan Denys. Neurotransmitter Dysregulation in OCD. Edited by Christopher Pittenger. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228163.003.0025.

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Obsessive-compulsive disorder (OCD) is associated with abnormalities in the cortico-striatal–thalamic–cortical (CSTC) circuitry, and may be associated with dysregulation of neurotransmitters within this network. The major neurotransmitters of the CSTC are serotonin, dopamine, glutamate and γ‎-aminobutyric acid (GABA. This chapter reviews evidence of the involvement of these neurotransmitters in OCD from pharmaocological, genetic, and imaging studies. yielding an integrated neurotransmitter model of OCD. It concludes that the neurotransmitter model of OCD involves dopaminergic and glutamatergic overactivity in frontostriatal pathways, along with diminished serotonergic and GABAergic neurotransmission in frontolimbic systems. These neurotransmitter imbalances may explain frontostriatal hyperactivity and impaired frontolimbic emotion regulation. Advancing our understanding of neurotransmitter abnormalities in OCD, and how abnormalities in different transmitter systems relate to one another, holds promise for the development of new pharmacotherapies.
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Bradshaw, John L. Developmental Disorders of the Frontostriatal System: Neuropsychological, Neuropsychiatric and Evolutionary Perspectives (Brain Damage, Behaviour and Cognition). Taylor & Francis Group, 2001.

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7

Bradshaw, John. Developmental Disorders of the Frontostriatal System: Neuropsychological, Neuropsychiatric and Evolutionary Perspectives (Brain Damage, Behaviour, and Cognition). Psychology Press, 2002.

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8

Robbins, T. W. Integrating the neurobiological and neuropsychological dimensions of autism. Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780198523499.003.0002.

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This chapter discusses the integration of the neurobiological and neuropsychological dimensions of autism. It includes a survey of the major neural theories of autism (medial temporal lobe hypothesis, the cerebellar hypothesis, the frontostriatal hypothesis, and evidence from neuroimaging and neuropsychology), and a summary of research suggestions (neuroimaging in a cognitive context, functional connectivity from neuroimaging, and cluster analysis of autistic symptoms).
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9

London, Edythe D., and Chelsea L. Robertson. Molecular Neuroimaging in Addictive Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0045.

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Molecular neuroimaging, using nuclear medicine procedures to evaluate brain function and markers for specific neurochemical systems, has substantially advanced the understanding of brain dysfunction linked to addictive disorders. Neuroimaging studies of human subjects and animal models has provided fundamental information on the neurobiology of vulnerability to addiction as well as the acute effects of drugs of abuse and the sequelae of chronic use, including the persistent states that maintain addiction and lead to relapse in those who initiate drug abstinence. A common theme that has emerged from decades of brain imaging points to frontostriatal dysfunction, which is a therapeutic target.
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Lee, Royce, Jennifer R. Fanning, and Emil F. Coccaro. The Clinical Neuroscience of Impulsive Aggression. Edited by Christian Schmahl, K. Luan Phan, Robert O. Friedel, and Larry J. Siever. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199362318.003.0008.

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Aggression can be categorized into three subtypes: premeditated aggression, frustration-related aggression, and impulsive aggression (IA), which is the focus of this chapter. It first delineates the social information processing model of IA and its neurobiological underpinnings, with a special focus on ventral prefrontal-amygdala, frontostriatal, and frontoparietal circuits. In these circuits, structural as well as functional alterations have been associated with IA. A large body of basic and clinical research has examined the role of neurotransmitters (glutamate, GABA) and neuromodulators (monoamines and neuropeptides) in mediating IA. The important role of the monoamines dopamine, serotonin, norepinephrine, and acetylcholine in the mediation of different aspects of IA and the pharmacological potential resulting from these alterations are depicted in the second half of the chapter. The chapter concludes with an overview of the most important etiological factors.
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Частини книг з теми "Frontostriatal"

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Ward, Tracey, Raphael Bernier, Cora Mukerji, Danielle Perszyk, James C. McPartland, Ellen Johnson, Susan Faja, et al. "Frontostriatal Disorder." In Encyclopedia of Autism Spectrum Disorders, 1345. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_100623.

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Koziol, Leonard F., and Deborah Ely Budding. "Familiarity and Novelty—Evaluating the Frontostriatal System." In Subcortical Structures and Cognition, 219–56. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-84868-6_8.

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"Frontostriatal Disorder." In Encyclopedia of Autism Spectrum Disorders, 2100. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-91280-6_300720.

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"Tourette's syndrome." In Developmental Disorders of the Frontostriatal System, 66–85. Psychology Press, 2014. http://dx.doi.org/10.4324/9781315782966-10.

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"Obsessive compulsive disorder." In Developmental Disorders of the Frontostriatal System, 86–107. Psychology Press, 2014. http://dx.doi.org/10.4324/9781315782966-11.

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"Attention de®cit hyperactivity disorder." In Developmental Disorders of the Frontostriatal System, 108–31. Psychology Press, 2014. http://dx.doi.org/10.4324/9781315782966-12.

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"Schizophrenia: A disorder of thought." In Developmental Disorders of the Frontostriatal System, 132–81. Psychology Press, 2014. http://dx.doi.org/10.4324/9781315782966-13.

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"Autism." In Developmental Disorders of the Frontostriatal System, 182–229. Psychology Press, 2014. http://dx.doi.org/10.4324/9781315782966-14.

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"Depression." In Developmental Disorders of the Frontostriatal System, 230–67. Psychology Press, 2014. http://dx.doi.org/10.4324/9781315782966-15.

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"An interpretation." In Developmental Disorders of the Frontostriatal System, 268–83. Psychology Press, 2014. http://dx.doi.org/10.4324/9781315782966-16.

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Тези доповідей конференцій з теми "Frontostriatal"

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Palchik, Alexander Beinusovich. "FRONTOSTRIATAL SYSTEMS FEATURES IN COGNITIVE AND BEHAVIOURAL DISORDERS DEVELOPMENT IN INFANTS." In Международный педагогический форум "Стратегические ориентиры современного образования". Уральский государственный педагогический университет, 2020. http://dx.doi.org/10.26170/kso-2020-126.

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