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Статті в журналах з теми "Flow Synthesis"

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Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 6 вересня 2023

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1

Yoshida, Jun-ichi, Aiichiro Nagaki, and Daisuke Yamada. "Continuous flow synthesis." Drug Discovery Today: Technologies 10, no. 1 (March 2013): e53-e59. http://dx.doi.org/10.1016/j.ddtec.2012.10.013.

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2

Xuefan Gu, Xuefan Gu, Peng Wang Peng Wang, Zhen Guo Zhen Guo, Weichao Du Weichao Du, and Sanbao Dong Sanbao Dong. "Synthesis and Evaluation of Hydroxymethyl Tetramides as Flow Improvers for Crude Oil." Journal of the chemical society of pakistan 42, no. 4 (2020): 488. http://dx.doi.org/10.52568/000658.

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Анотація:

In this work, a series of hydroxymethyl tetramide (HMTEA) was synthesized from vegetable oil, triacetylenetetramine and hexamethylenetetramine, which was evaluated as viscosity reducer and pour point depressor for crude oil. The results showed that HMTE has a good viscosity reduction effect on the crude oil from Yanchang Oilfield, with the highest viscosity reduction rate of 93%. The highest pour point reduction depression was achieved as 6.5℃. Differential scanning calorimetry and paraffin crystal morphology characterization were conducted on the crude oil to elucidate the mechanism of viscosity reduction and pour point depression.

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3

Xuefan Gu, Xuefan Gu, Peng Wang Peng Wang, Zhen Guo Zhen Guo, Weichao Du Weichao Du, and Sanbao Dong Sanbao Dong. "Synthesis and Evaluation of Hydroxymethyl Tetramides as Flow Improvers for Crude Oil." Journal of the chemical society of pakistan 42, no. 4 (2020): 488. http://dx.doi.org/10.52568/000658/jcsp/42.04.2020.

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Анотація:

In this work, a series of hydroxymethyl tetramide (HMTEA) was synthesized from vegetable oil, triacetylenetetramine and hexamethylenetetramine, which was evaluated as viscosity reducer and pour point depressor for crude oil. The results showed that HMTE has a good viscosity reduction effect on the crude oil from Yanchang Oilfield, with the highest viscosity reduction rate of 93%. The highest pour point reduction depression was achieved as 6.5℃. Differential scanning calorimetry and paraffin crystal morphology characterization were conducted on the crude oil to elucidate the mechanism of viscosity reduction and pour point depression.

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4

Kamptmann, Sonja B., and Steven V. Ley. "Facilitating Biomimetic Syntheses of Borrerine Derived Alkaloids by Means of Flow-Chemical Methods." Australian Journal of Chemistry 68, no. 4 (2015): 693. http://dx.doi.org/10.1071/ch14530.

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Анотація:

Flow chemistry is widely used nowadays in synthetic chemistry and has increasingly been applied to complex natural product synthesis. However, to date flow chemistry has not found a place in the area of biomimetic synthesis. Here we show the syntheses of borrerine derived alkaloids, indicating that we can use biomimetic principles in flow to prepare complex architectures in a single step.

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5

Junkers, Thomas, and Richard Hoogenboom. "Advanced polymer flow synthesis." European Polymer Journal 80 (July 2016): 175–76. http://dx.doi.org/10.1016/j.eurpolymj.2016.05.006.

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6

Kobayashi, Shū. "Flow “Fine” Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods." Chemistry - An Asian Journal 11, no. 4 (October 20, 2015): 425–36. http://dx.doi.org/10.1002/asia.201500916.

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7

Mougeot, Romain, Philippe Jubault, Julien Legros, and Thomas Poisson. "Continuous Flow Synthesis of Propofol." Molecules 26, no. 23 (November 26, 2021): 7183. http://dx.doi.org/10.3390/molecules26237183.

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Анотація:

Herein, we report a continuous flow process for the synthesis of 2,6-diisopropylphenol—also known as Propofol—a short-acting intravenous anesthesia, widely used in intensive care medicine to provide sedation and hypnosis. The synthesis is based on a two-step procedure: a double Friedel–Crafts alkylation followed by a decarboxylation step, both under continuous flow.

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8

Watts, Paul, and Charlotte Wiles. "Micro reactors, flow reactors and continuous flow synthesis." Journal of Chemical Research 36, no. 4 (April 1, 2012): 181–93. http://dx.doi.org/10.3184/174751912x13311365798808.

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9

Britton, Joshua, and Colin L. Raston. "Multi-step continuous-flow synthesis." Chemical Society Reviews 46, no. 5 (2017): 1250–71. http://dx.doi.org/10.1039/c6cs00830e.

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10

Kyprianou, Dimitris, Michael Berglund, Giovanni Emma, Grzegorz Rarata, David Anderson, Gabriela Diaconu, and Vassiliki Exarchou. "Synthesis of 2,4,6-Trinitrotoluene (TNT) Using Flow Chemistry." Molecules 25, no. 16 (August 6, 2020): 3586. http://dx.doi.org/10.3390/molecules25163586.

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Анотація:

This paper describes the nitration of 2,4-dinitrotoluene (DNT) and its conversion to 2,4,6-trinitrotoluene (TNT) at a gram scale with the use of a fully automated flow chemistry system. The conversion of DNT to TNT traditionally requires the use of highly hazardous reagents like fuming sulfuric acid (oleum), fuming nitric acid (90–100%), and elevated temperatures. Flow chemistry offers advantages compared to conventional syntheses including a high degree of safety and simpler multistep automation. The configuration and development of this automated process based on a commercially available flow chemistry system is described. A high conversion rate (>99%) was achieved. Unlike established synthetic methods, ordinary nitrating mixture (65% HNO3/98% H2SO4) and shorter reaction times (10–30 min) were applied. The viability of flow nitration as a means of safe and continuous synthesis of TNT was investigated. The method was optimized using an experimental design approach, and the resulting process is safer, faster, and more efficient than previously reported TNT synthesis procedures. We compared the flow chemistry and batch approaches, including a provisional cost calculation for laboratory-scale production (a thorough economic analysis is, however, beyond the scope of this article). The method is considered fit for purpose for the safe production of high-purity explosives standards at a gram scale, which are used to verify that the performance of explosive trace detection equipment complies with EU regulatory requirements.

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11

Delville, Mariëlle M. E., Jan C. M. van Hest, and Floris P. J. T. Rutjes. "Ethyl diazoacetate synthesis in flow." Beilstein Journal of Organic Chemistry 9 (September 5, 2013): 1813–18. http://dx.doi.org/10.3762/bjoc.9.211.

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Ethyl diazoacetate is a versatile compound in organic chemistry and frequently used on lab scale. Its highly explosive nature, however, severely limits its use in industrial processes. The in-line coupling of microreactor synthesis and separation technology enables the synthesis of this compound in an inherently safe manner, thereby making it available on demand in sufficient quantities. Ethyl diazoacetate was prepared in a biphasic mixture comprising an aqueous solution of glycine ethyl ester, sodium nitrite and dichloromethane. Optimization of the reaction was focused on decreasing the residence time with the smallest amount of sodium nitrite possible. With these boundary conditions, a production yield of 20 g EDA day−1 was achieved using a microreactor with an internal volume of 100 μL. Straightforward scale-up or scale-out of microreactor technology renders this method viable for industrial application.

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12

Sokolenko, A., I. Maksymenko, and V. Kostyuk. "Synthesis of activated flow mixers." Scientific Works of National University of Food Technologies 25, no. 6 (December 2019): 102–13. http://dx.doi.org/10.24263/2225-2924-2019-25-6-14.

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13

Chen, An Bang, Xin Li, Yang Zhi Zhou, Ling Ling Huang, Zheng Fang, Hai Feng Gan, and Kai Guo. "Continuous Flow Synthesis of Coumarin." Advanced Materials Research 781-784 (September 2013): 936–41. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.936.

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Анотація:

Flow chemistry, as a rapidly emerging technology, is exploited to provide a safe and scalable route for the pharmaceutically interesting coumarin. Here, a continuous flow approach for the generation of coumarin is reported, which relies on the two connected coil reactors design. The synthesis of coumarin has been performed successfully in high conversion on small scale and can be scaled up substantially.

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14

Andrews, R. P. "Automated continuous flow peptide synthesis." Nature 319, no. 6052 (January 1, 1986): 429–30. http://dx.doi.org/10.1038/319429a0.

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15

Hongchao Zhou, Ho-Lin Chen, and Jehoshua Bruck. "Synthesis of Stochastic Flow Networks." IEEE Transactions on Computers 63, no. 5 (May 2014): 1234–47. http://dx.doi.org/10.1109/tc.2012.270.

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16

Laudadio, Gabriele, Hannes P. L. Gemoets, Volker Hessel, and Timothy Noël. "Flow Synthesis of Diaryliodonium Triflates." Journal of Organic Chemistry 82, no. 22 (July 20, 2017): 11735–41. http://dx.doi.org/10.1021/acs.joc.7b01346.

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17

Elsherbini, Mohamed, and Thomas Wirth. "Electroorganic Synthesis under Flow Conditions." Accounts of Chemical Research 52, no. 12 (November 6, 2019): 3287–96. http://dx.doi.org/10.1021/acs.accounts.9b00497.

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18

Naber, John R., C. Oliver Kappe, and Jaan A. Pesti. "Flow Chemistry Enabling Efficient Synthesis." Organic Process Research & Development 24, no. 10 (October 16, 2020): 1779–80. http://dx.doi.org/10.1021/acs.oprd.0c00406.

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19

Simon, Mark D., Patrick L. Heider, Andrea Adamo, Alexander A. Vinogradov, Surin K. Mong, Xiyuan Li, Tatiana Berger, et al. "Rapid Flow-Based Peptide Synthesis." ChemBioChem 15, no. 5 (March 11, 2014): 713–20. http://dx.doi.org/10.1002/cbic.201300796.

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20

Colella, Marco, Leonardo Degennaro, and Renzo Luisi. "Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles." Molecules 25, no. 14 (July 16, 2020): 3242. http://dx.doi.org/10.3390/molecules25143242.

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Анотація:

Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis. In this review, the role of flow technology in the preparation of indole derivatives is showcased. Selected examples have been described with the aim to provide readers with an overview on the tactics and technologies used for targeting indole scaffolds.

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21

Edie Sasito, Edie Sasito, Bambang Soegijono, and Azwar Manaf. "Structure and Design Flow Injection Synthesis Method of Co-precipitation Forming Magnetic Materials Process." Indian Journal of Applied Research 3, no. 9 (October 1, 2011): 403–7. http://dx.doi.org/10.15373/2249555x/sept2013/119.

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22

He, Yujuan, Ki-Joong Kim, and Chih-hung Chang. "Segmented Microfluidic Flow Reactors for Nanomaterial Synthesis." Nanomaterials 10, no. 7 (July 21, 2020): 1421. http://dx.doi.org/10.3390/nano10071421.

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Анотація:

Microfluidic reactors have remarkably promoted the synthesis and investigation of advanced nanomaterials due to their continuous mode and accelerated heat/mass transfer. Notably, segmented microfluidic flow reactors (SMFRs) are an important class of microfluidic reactors that have been developed to accurately manipulate nanomaterial synthesis by further improvement of the residence time distributions and unique flow behaviors. This review provided a survey of the nanomaterial synthesis in SMFRs for the aspects of fluid dynamics, flow patterns, and mass transfer among and within distinct phases and provided examples of the synthesis of versatile nanomaterials via the use of different flow patterns.

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23

Munyebvu, Neal, Julia Nette, Stavros Stavrakis, Philip D. Howes, and Andrew J. DeMello. "Transforming Nanomaterial Synthesis with Flow Chemistry." CHIMIA 77, no. 5 (May 31, 2023): 312. http://dx.doi.org/10.2533/chimia.2023.312.

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Анотація:

Microfluidic methods for the synthesis of nanomaterials allow the generation of high-quality products with outstanding structural, electronic and optical properties. At a fundamental level, this is engendered by the ability to control both heat and mass transfer in a rapid and precise manner, but also by the facile integration of in-line characterization tools and machine learning algorithms. Such integrated platforms provide for exquisite control over material properties during synthesis, accelerate the optimization of electronic and optical properties and bestow new insights into the optoelectronic properties of nanomaterials. Herein, we present a brief perspective on the role that microfluidic technologies can play in nanomaterial synthesis, with a particular focus on recent studies that incorporate in-line optical characterization and machine learning. We also consider the importance and challenges associated with integrating additional functional components within experimental workflows and the upscaling of microfluidic platforms for production of industrial-scale quantities of nanomaterials.

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24

He, Xiaoai, Aijuan Lu, Jin Cheng, Junfang Chen, Qianhui Song, Wenfang Liu, and Chuanpin Chen. "Overview of the Application of Flow Microreactors in the Synthesis of Silver Nanomaterials." Nano 12, no. 11 (November 2017): 1730002. http://dx.doi.org/10.1142/s179329201730002x.

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The unique electrical, optical and biological properties of silver nanomaterials have attracted significant attention of many researchers. Since the size and shape of silver nanomaterials have significant effects on the properties of silver nanomaterials, extensive research has focused on synthesis and characterization of silver nanomaterials. However, almost all of the syntheses of silver nanomaterials were carried out in traditional batch reactors, which typically suffer from inhomogeneous mixing and corresponding spatial variations under reaction conditions, ultimately leading to poor quality of the final nanomaterials. Recently, the emerging microfluidic technology not only furnishes novel strategies for the synthesis of silver nanomaterials but also brings great opportunities and impetus to improve the quality and yield of silver nanomaterials due to enhanced mass and heat transfer. The current paper reviews recent achievements in the synthesis of silver nanomaterials in flow microreactors. Various strategies adopted for the synthesis of silver nanomaterials in microreactors are presented and compared, including synthesis in single-phase and multi-phase flow microreactors. In addition, the factors that affect the size and size distribution of silver nanomaterials in flow microreactors synthesis are also discussed briefly.

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25

Britton, Joshua, Sudipta Majumdar, and Gregory A. Weiss. "Continuous flow biocatalysis." Chemical Society Reviews 47, no. 15 (2018): 5891–918. http://dx.doi.org/10.1039/c7cs00906b.

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26

ZHAO, YUTAO, MING ZHANG, and YUNCAI LIU. "FLOW VIDEO SYNTHESIS FROM AN IMAGE." International Journal of Pattern Recognition and Artificial Intelligence 24, no. 03 (May 2010): 421–31. http://dx.doi.org/10.1142/s0218001410007981.

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Анотація:

A new method of image based flow analysis and synthesis from a still image is presented. We analyze the flow parts from a still image in order to get continuous video by image matting, image inpainting, projecting flow field onto the image and modulation. We construct and project 3D flow models onto still images and propose 2D modulation methods that are more suitable and practical to our synthesis. Our technique can edit still images that have flow parts. The experiments show the method is effective.

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27

Hollenbach, Rebecca, Delphine Muller, André Delavault, and Christoph Syldatk. "Continuous Flow Glycolipid Synthesis Using a Packed Bed Reactor." Catalysts 12, no. 5 (May 18, 2022): 551. http://dx.doi.org/10.3390/catal12050551.

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Glycolipids are a class of biodegradable biosurfactants that are non-toxic and based on renewables, making them a sustainable alternative to petrochemical surfactants. Enzymatic synthesis allows a tailor-made production of these versatile compounds using sugar and fatty acid building blocks with rationalized structures for targeted applications. Therefore, glycolipids can be comprehensively designed to outcompete conventional surfactants regarding their physicochemical properties. However, enzymatic glycolipid processes are struggling with both sugars and fatty acid solubilities in reaction media. Thus, continuous flow processes represent a powerful tool in designing efficient syntheses of sugar esters. In this study, a continuous enzymatic glycolipid production catalyzed by Novozyme 435® is presented as an unprecedented concept. A biphasic aqueous–organic system was investigated, allowing for the simultaneous solubilization of sugars and fatty acids. Owing to phase separation, the remaining non-acylated glucose was easily separated from the product stream and was refed to the reactor forming a closed-loop system. Productivity in the continuous process was higher compared to a batch one, with space–time yields of up to 1228 ± 65 µmol/L/h. A temperature of 70 °C resulted in the highest glucose-6-O-decanoate concentration in the Packed Bed Reactor (PBR). Consequently, the design of a continuous biocatalytic production is a step towards a more competitive glycolipid synthesis in the aim for industrialization.

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28

Amii, Hideki, Aiichiro Nagaki, and Jun-ichi Yoshida. "Flow microreactor synthesis in organo-fluorine chemistry." Beilstein Journal of Organic Chemistry 9 (December 5, 2013): 2793–802. http://dx.doi.org/10.3762/bjoc.9.314.

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Organo-fluorine compounds are the substances of considerable interest in various industrial fields due to their unique physical and chemical properties. Despite increased demand in wide fields of science, synthesis of fluoro-organic compounds is still often faced with problems such as the difficulties in handling of fluorinating reagents and in controlling of chemical reactions. Recently, flow microreactor synthesis has emerged as a new methodology for producing chemical substances with high efficiency. This review outlines the successful examples of synthesis and reactions of fluorine-containing molecules by the use of flow microreactor systems to overcome long-standing problems in fluorine chemistry.

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29

Dai, Pinxuan, and Ning Xie. "Deep Flow Rendering: View Synthesis via Layer‐aware Reflection Flow." Computer Graphics Forum 41, no. 4 (July 2022): 139–48. http://dx.doi.org/10.1111/cgf.14593.

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30

Nikbin, Nikzad, and Paul Watts. "Solid-Supported Continuous Flow Synthesis in Microreactors Using Electroosmotic Flow." Organic Process Research & Development 8, no. 6 (November 2004): 942–44. http://dx.doi.org/10.1021/op049857x.

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31

Watts, Paul, and Chralotte Wiles. "ChemInform Abstract: Micro Reactors, Flow Reactors and Continuous Flow Synthesis." ChemInform 43, no. 33 (July 19, 2012): no. http://dx.doi.org/10.1002/chin.201233234.

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32

Puglisi, Alessandra, Sergio Rossi, Fabian Herbrik, Fabrizio Medici, and Maurizio Benaglia. "In-flow enantioselective homogeneous organic synthesis." Green Processing and Synthesis 10, no. 1 (January 1, 2021): 768–78. http://dx.doi.org/10.1515/gps-2021-0073.

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Abstract The use of enabling technologies, such as flow reactors, three-dimensional-printed devices, and electrochemistry, in the stereoselective synthesis of enantioenriched compounds is presented, with a special focus on the most significant contributions to the field reported in the last few years.

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33

Piccardi, Riccardo, Anais Coffinet, Erica Benedetti, Serge Turcaud, and Laurent Micouin. "Continuous Flow Synthesis of Dimethylalkynylaluminum Reagents." Synthesis 48, no. 19 (July 7, 2016): 3272–78. http://dx.doi.org/10.1055/s-0035-1561484.

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Анотація:

A new process for the synthesis of dimethylalkynylaluminum reagents under flow conditions is described. It involves a base-catalyzed alumination of terminal alkynes using a resin-supported organocatalyst. Final organometallic species are obtained in solution, and can further react with various aldehydes or nitrones.

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34

Di Filippo, Mara, and Marcus Baumann. "Continuous Flow Synthesis of Anticancer Drugs." Molecules 26, no. 22 (November 19, 2021): 6992. http://dx.doi.org/10.3390/molecules26226992.

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Анотація:

Continuous flow chemistry is by now an established and valued synthesis technology regularly exploited in academic and industrial laboratories to bring about the improved preparation of a variety of molecular structures. Benefits such as better heat and mass transfer, improved process control and safety, a small equipment footprint, as well as the ability to integrate in-line analysis and purification tools into telescoped sequences are often cited when comparing flow to analogous batch processes. In this short review, the latest developments regarding the exploitation of continuous flow protocols towards the synthesis of anticancer drugs are evaluated. Our efforts focus predominately on the period of 2016–2021 and highlight key case studies where either the final active pharmaceutical ingredient (API) or its building blocks were produced continuously. It is hoped that this manuscript will serve as a useful synopsis showcasing the impact of continuous flow chemistry towards the generation of important anticancer drugs.

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35

Gomez, M. Victoria, and Antonio de la Hoz. "NMR reaction monitoring in flow synthesis." Beilstein Journal of Organic Chemistry 13 (February 14, 2017): 285–300. http://dx.doi.org/10.3762/bjoc.13.31.

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Анотація:

Recent advances in the use of flow chemistry with in-line and on-line analysis by NMR are presented. The use of macro- and microreactors, coupled with standard and custom made NMR probes involving microcoils, incorporated into high resolution and benchtop NMR instruments is reviewed. Some recent selected applications have been collected, including synthetic applications, the determination of the kinetic and thermodynamic parameters and reaction optimization, even in single experiments and on the μL scale. Finally, software that allows automatic reaction monitoring and optimization is discussed.

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36

Martin, Alex D., Ali R. Siamaki, Katherine Belecki, and B. Frank Gupton. "A flow-based synthesis of telmisartan." Journal of Flow Chemistry 5, no. 3 (September 2015): 145–47. http://dx.doi.org/10.1556/jfc-d-15-00002.

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37

Shekhovtsov, Valentin V., O. Volokitin, N. Tsvetkov, G. Volokitin, and N. Skripnikova. "Aluminosilicate Microsphere Synthesis in Plasma Flow." Materials Science Forum 906 (September 2017): 131–36. http://dx.doi.org/10.4028/www.scientific.net/msf.906.131.

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The paper presents theoretical and experimental results on the synthesis of ash-based microspheres using the high-temperature plasma treatment. The dynamic motion of particles and their melting are considered depending on the initial porosity of the raw material modified by 3200K plasma treatment. Physicochemical studies relate to the original raw material and microspheres produced therefrom.

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38

Bhat, Kiran S., Steven M. Seitz, Jessica K. Hodgins, and Pradeep K. Khosla. "Flow-based video synthesis and editing." ACM Transactions on Graphics 23, no. 3 (August 2004): 360–63. http://dx.doi.org/10.1145/1015706.1015729.

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39

Degennaro, Leonardo, Claudia Carlucci, Sonia De Angelis, and Renzo Luisi. "Flow technology for organometallic-mediated synthesis." Journal of Flow Chemistry 6, no. 3 (September 2016): 136–66. http://dx.doi.org/10.1556/1846.2016.00014.

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40

Rawsthorne, S., S. Fox, L. Hill, M. Hills, P. Johnson, S. Kubis, P. Nield, and M. Pike. "Carbon flow for fatty acid synthesis." Biochemical Society Transactions 30, no. 5 (October 1, 2002): A100. http://dx.doi.org/10.1042/bst030a100c.

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41

Hartman, Ryan L., and Klavs F. Jensen. "Microchemical systems for continuous-flow synthesis." Lab on a Chip 9, no. 17 (2009): 2495. http://dx.doi.org/10.1039/b906343a.

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42

Webb, Damien, and Timothy F. Jamison. "Continuous flow multi-step organic synthesis." Chemical Science 1, no. 6 (2010): 675. http://dx.doi.org/10.1039/c0sc00381f.

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43

Cave, Alison C., Joanne S. Ingwall, Jan Friedrich, Ronglih Liao, Kurt W. Saupe, Carl S. Apstein, and Franz R. Eberli. "ATP Synthesis During Low-Flow Ischemia." Circulation 101, no. 17 (May 2, 2000): 2090–96. http://dx.doi.org/10.1161/01.cir.101.17.2090.

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Fuse, Shinichiro, Nobutake Tanabe, Masahito Yoshida, Hayato Yoshida, Takayuki Doi, and Takashi Takahashi. "Continuous-flow synthesis of vitamin D3." Chemical Communications 46, no. 46 (2010): 8722. http://dx.doi.org/10.1039/c0cc02239j.

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Seyler, Helga, Wallace W. H. Wong, David J. Jones, and Andrew B. Holmes. "Continuous Flow Synthesis of Fullerene Derivatives." Journal of Organic Chemistry 76, no. 9 (May 6, 2011): 3551–56. http://dx.doi.org/10.1021/jo2001879.

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Hayashi, Yujiro, and Shin Ogasawara. "Multistep Continuous-Flow Synthesis of (–)-Oseltamivir." Synthesis 49, no. 02 (November 3, 2016): 424–28. http://dx.doi.org/10.1055/s-2016-0036-1588899.

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Masuda, Koichiro, Tomohiro Ichitsuka, Nagatoshi Koumura, Kazuhiko Sato, and Shū Kobayashi. "Flow fine synthesis with heterogeneous catalysts." Tetrahedron 74, no. 15 (April 2018): 1705–30. http://dx.doi.org/10.1016/j.tet.2018.02.006.

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Krchňák, Viktor, Josef Vágner, Martin Flegel, and Otakar Mach. "Continuous-flow solid-phase peptide synthesis." Tetrahedron Letters 28, no. 38 (January 1987): 4469–72. http://dx.doi.org/10.1016/s0040-4039(00)96541-9.

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Seyler, Helga, David J. Jones, Andrew B. Holmes, and Wallace W. H. Wong. "Continuous flow synthesis of conjugated polymers." Chem. Commun. 48, no. 10 (2012): 1598–600. http://dx.doi.org/10.1039/c1cc14315h.

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Zaquen, Neomy, Maarten Rubens, Nathaniel Corrigan, Jiangtao Xu, Per B. Zetterlund, Cyrille Boyer, and Tanja Junkers. "Polymer Synthesis in Continuous Flow Reactors." Progress in Polymer Science 107 (August 2020): 101256. http://dx.doi.org/10.1016/j.progpolymsci.2020.101256.

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