Дисертації з теми "Fission pathways"
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Pazo, Pelegrí Esther 1993. "New pathways regulating MBF-dependent transcription in fission yeast." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/672476.
Повний текст джерелаAl final de la fase G1, les cèl·lules han de decidir entre continuar proliferant o romandre en un estat de quiescència (G0). Aquest punt de decisió, conegut com “Start” en llevats o “Restriction Point” en metazous, compromet irreversiblement a les cèl·lules a completar el següent cicle cel·lular, i està principalment regulat per l’activitat CDK de G1 i per la inducció del programa transcripcional de G1/S. El complex MBF (homòleg funcional de pRB-E2F en metazous) es el factor de transcripció encarregat de la inducció de l’onada transcripcional de G1/S en el llevat de fissió Schizosaccharomyces pombe. Anteriorment, vam descriure com els repressors Nrm1 i Yox1 s’uneixen al complex MBF al final de la fase S per inhibir la seva activitat. Fins ara, els mecanismes implicats en l’activació de MBF a l’inici d’un cicle cel·lular no pertorbat s’han mantingut desconeguts. En aquest treball, hem vist que Nrm1 es el responsable de l’activació transcripcional depenent de MBF mitjançant un mecanisme de dos passos. La seva fosforilació per CDK1 i la seva posterior degradació per APCSte9 donen lloc a l’activació irreversible de MBF fins al final de la fase S. També hem estudiant el paper dels remodeladors de cromatina en el control del programa transcripcional de G1/S. En aquest sentit, hem trobat que els complexes remodeladors de la cromatina SWI/SNF i RSC són reclutats als gens regulats per MBF i tenen un clar impacte en l’activació transcripcional de G1/S. A més, hem creat un reporter fluorescent de vida curta per mesurar canvis petits i transitoris de l’activitat MBF in vivo mitjançant citometria de flux, per a poder identificar nous reguladors de MBF.
Mutavchiev, Delyan Rumenov. "Regulation of fission yeast cell polarity by stress-response pathways." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29006.
Повний текст джерелаRoberts, Theresa Helen. "The role of Ypt3p in the membrane traffic pathways of Schizosaccharomyces pombe." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321487.
Повний текст джерелаMakarenko, Rostyslav. ""Adaptive mutations" in the S/MAPK pathways provide selective advantage in quiescent fission yeast." Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS253.pdf.
Повний текст джерелаQuiescence and proliferation reflect two fundamentally different cellular stages, yet very limited information exists on how cells maintain their genome stability in quiescence. Using nitrogen-starved fission yeast as a model for quiescence, our laboratory has demonstrated that cells are not only subject to DNA damage in G0 but also accumulate replication-independent mutations linearly with time. In our current work, we have demonstrated that mutations accumulating in growth-arrested phase undergo a selection process in quiescence similar to that observed in E. coli. Selection favors mutations that affect functions of the genes of the MAP-kinase (mkh1, pek1, pmk1) and SAP-kinase pathways (win1, wis1, sty1), and their downstream targets (pmc1, sgf73, tif452). These genes represent core cellular signaling that regulates cell proliferation, cell differentiation, and cell death conserved among all eukaryotic species from yeast to human. Mutations in components of the S/MAPK pathways and their regulators are associated with multiple diseases in humans, primary cancer and degenerative neuronal death accumulated with ageing. In this work, we have demonstrated that wild-type cells dying in quiescence release traces of nitrogen that triggers the viable population to exit from quiescence. The wild-type cells are dying during their entry into S-phase releasing more nitrogen. Thus, mutants in the S/MAPK pathways are better scavengers and selection in quiescence is characterized by the ability of the mutant to resume cycling in quiescence coupled with a resistance to programed cell death
Sacks, Jessica Erin. "Targeting Mitochondrial Pathways in Obesity and Type 2 Diabetes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1522935947635474.
Повний текст джерелаGabrielli, Natalia 1978. "Cross-talk between iron starvation and H202 signaling pathways in Schizosaccharomyces pombe." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/108037.
Повний текст джерелаEl peróxido de hidrógeno (H2O2) es un agente oxidante que además de participar en cascadas de señalización produce toxicidad por daño oxidativo. Parte de su toxicidad se explica por su reactividad con hierro. Así, las concentraciones de hierro en el interior celular han de estar estrictamente reguladas. Usando la levadura de fisión, Schizosaccharomyces pombe, como un sistema modelo, estudiamos las relaciones entre H2O2 y el sistema de respuesta a déficit de hierro. Genes como fep1, pcl1 y sib2, importantes para mantener su homeostasis, fueron encontrados en un análisis de 2700 mutantes de S. pombe, tras tratamiento con diferentes agentes oxidantes. Inesperadamente encontramos que H2O2 desencadena una respuesta transcripcional de déficit de hierro, incluyendo aumento de su entrada y disminución de su consumo. Ésta es una respuesta accidental debido a la sobreexpresión de proteínas como catalasa, una hemoproteína, consumidoras masivas de hierro. Encontramos además que la glutaredoxina Grx4 contiene un clúster de hierro-azufre implicado en sensar hierro. Finalmente, identificamos, caracterizamos y delecionamos el homólogo de frataxina en S. pombe, pfh1. Deficiencias en frataxina provocan ataxia de Friedreich. Los mecanismos por los cuales se desencadena esta enfermedad están todavía por elucidar, pero S. pombe es un buen sistema modelo para su estudio.
Gupta, Sneha. "Understanding Regulation of the Cytoskeleton during Cell Cycle Transitions through Examination of Crosstalk between Homologous Fission Yeast Pathways, Septation Initiation Network and Morphogenesis ORB6 Network: A Dissertation." eScholarship@UMMS, 2013. http://escholarship.umassmed.edu/gsbs_diss/693.
Повний текст джерелаRavenel, Kévin. "Étude des mécanismes d’adaptation des espèces du genre Scedosporium aux environnements pollués et pathogénie." Electronic Thesis or Diss., Angers, 2024. https://dune.univ-angers.fr/documents/dune18768.
Повний текст джерелаFungi of the Scedosporium genus are saprophytes, opportunistic pathogens in humans. Several studies have revealed their ability to degrade polyaromatic molecules derived from environmental pollutants. Our previous work demonstrates that species of the genus Scedosporium are able to grow in the presence of lignin. In the environment, the catabolic steps of polyaromatic molecules converge on a limited number of simple aromatic molecules (catechol, protocatechuate, hydroxyquinol and gentisate), which are handled by central intermediate pathways, also known as fission pathways. Bioinformatics analysis enabled us to characterize the gene clusters degrading these central molecules in S. apiospermum and S. aurantiacum. Experimental results demonstrate the functionality of the gentisate pathway cluster in the presence of this molecule. The dioxygenases that catalyze benzene ring opening, a key step in the catabolic mechanism, are prime targets for the design of deletion strains.To this end, CRISPR-Cas9 technology has been successfully adapted and optimized in two S. apiospermum strains: a wild-type strain and a Δku70strain. To achieve this, different protocols were defined depending on the functionality of the NHEJ repair system. Thus, deletion strains for the gene encoding dioxygenase were generated for each pathway. These deletions have a different impact on the growth of these strains on media in the presence of the corresponding core molecules. Under certain conditions, these results suggest the implementation of compensatory mechanisms that remain to be defined. Finally, this work established for the first time a link between the degradation of aromatic molecules and the pathogenesis of an opportunistic fungal pathogen of man in in vitro experiments
Didmon, Mark Paul. "Characterisation of adaption mechanisms in the intracellular signalling pathway of the Schizosaccharomyces pombe pheromone communication system." Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367965.
Повний текст джерелаWilkinson, Marc George. "Functional analysis of the STY1 stress-activated map kinase pathway of fission yeast." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286786.
Повний текст джерелаMorris, Zachary James. "Actin Binding Proteins Regulate the Localization of the Fission Yeast Hippo Pathway Protein Mob1p." University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1533229650651521.
Повний текст джерелаProchnik, Simon Edward. "The role of the fission yeast Wis1 pathway in stress response and cell cycle control." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/11284.
Повний текст джерелаFrampton, Jonathan Mark. "Characterisation of UBC13 and MMS2 and their involvement in the post-replication repair pathway in fission yeast." Thesis, University of Sussex, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421510.
Повний текст джерелаZhu, Yihua. "Roles of Interphase Node Protein Nod1 and UNC-13/Munc13 Protein Ync13 during Fission Yeast Cytokinesis." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503259807015196.
Повний текст джерелаAspuria, Paul-Joseph Penaflor. "Genetic analysis of the Tsc/Rheb/Tor pathway in fission yeast involvement in nutrient uptake and drug resistance." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1680035091&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Повний текст джерелаMiller, Scott Garrett. "Mutagenic analysis of the decarboxylases and hydratases in parallel meta-fission pathways." 2008. http://hdl.handle.net/2152/17940.
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Nagampalli, Vijay Krishna. "Design and Application of Temperature Sensitive Mutants in Essential Factors of RNA Splicing and RNA Interference Pathway in Schizosaccharomyces Pombe." Thesis, 2014. http://etd.iisc.ac.in/handle/2005/3515.
Повний текст джерелаNagampalli, Vijay Krishna. "Design and Application of Temperature Sensitive Mutants in Essential Factors of RNA Splicing and RNA Interference Pathway in Schizosaccharomyces Pombe." Thesis, 2014. http://etd.iisc.ernet.in/2005/3515.
Повний текст джерелаTaylor, Stephanie Michelle 1985. "Biosynthesis of coenzyme M and the catabolism of halogenated aromatic compounds." Thesis, 2012. http://hdl.handle.net/2152/28462.
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