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Дисертації з теми "Fibroblasts reprogramming"

Автор: Grafiati

Опубліковано: 14 березня 2023

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1

Elyaderani, Parisa Javadian. "Reprogramming of fibroblasts by the Piwil2 gene." Thesis, University of Newcastle Upon Tyne, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613436.

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The Piwil2 gene belongs to the Piwi family of genes conserved during evolution from Arabidopsis to human. The Piwi family genes are considered as stem cell modulators functioning in meristem cell division in Arabidopsis and germ stem cell propagation in C.elegans and in mammals. Although some essential functions such as germ cell development, transposition repression, epigenetic modification and translational regulation, as well as stem cell and cancer stem cell maintenance, are attributed to this family of genes, the detailed mechanism of the function of these genes still remains elusive. In

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2

Rohanisarvestani, Leili. "Integration-free mRNA reprogramming of human fibroblasts: The study of aging upon reprogramming." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-159985.

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The ability to reprogram adult somatic cells into induced pluripotent stem (iPS) cells could provide a valuable implement for in vitro disease modeling and drug discovery. More importantly, they may potentially serve as an unlimited source of cells for regenerative medicine. However, most of the iPS cells have been generated by retroviral vectors, and therefore they carry the risk of viral integration into the host genome. This problem prevents their use for clinical applications and regenerative medicine. mRNA-mediated delivery of reprogramming factors is an alternative approach for cellular

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3

Karamariti, Eirini. "Direct reprogramming of fibroblasts into smooth muscle cells." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/direct-reprogramming-of-fibroblasts-into-smooth-muscle-cells(d0feb08f-4d4a-4ded-a2b3-00e41c575cec).html.

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The generation of induced pluripotent stem (iPS) cells is a useful tool for regenerative medicine. However, the risk of tumor development of the aforementioned cells should be addressed before they can be used for clinical applications. During the reprogramming process a number of signal pathways are activated, which may lead to direct differentiation of specific cell lineages prior to the cells reaching the pluripotent state. In order to test this hypothesis we designed a combined protocol of reprogramming and differentiation in an attempt to achieve direct differentiation of fibroblasts to s

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4

Rohanisarvestani, Leili [Verfasser], Friedemann [Gutachter] Horn, and Torsten [Gutachter] Remmerbach. "Integration-free mRNA reprogramming of human fibroblasts: The study of aging upon reprogramming / Leili Rohanisarvestani ; Gutachter: Friedemann Horn, Torsten Remmerbach." Leipzig : Universitätsbibliothek Leipzig, 2015. http://d-nb.info/1238525598/34.

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5

Hao, Ru. "Reprogramming of mesenchymal stem cells and adult fibroblasts following nuclear transfer in rabbits." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-96652.

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6

MAZZARA, PIETRO GIUSEPPE. "TWO FACTOR BASED REPROGRAMMING OF FIBROBLASTS AND INDUCED PLURIPOTENT STEM CELLS INTO MYELINOGENIC SCHWANN CELLS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199039.

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Le cellule di Schwann (SC) sono cellule derivate dalla cresta neurale (NC) in grado di produrre la guaina mielinica avvolgendo gli assoni neuronali nel sistema nervoso periferico (PNS). I trapianti di SC potrebbero diventare un'opportunità terapeutica interessante per il trattamento delle lesioni del midollo spinale, dei nervi periferici e delle malattie demielinizzanti del PNS. Tuttavia, questi approcci terapeutici sono fortemente limitati dall'attuale mancanza di una fonte rinnovabile di SC. Le strategie di riprogrammazione cellulare si sono rivelate efficaci nel fornire una varietà di cellu

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7

Tanabe, Koji. "Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts." Kyoto University, 2013. http://hdl.handle.net/2433/180465.

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8

Bachamanda, Somesh Dipthi [Verfasser]. "Induced cardiomyocyte precursor cells obtained by direct reprogramming of cardiac fibroblasts / Dipthi Bachamanda Somesh." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1223925676/34.

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9

Raciti, Marilena. "Reprogramming fibroblasts to neural-stem-like cells by structured overexpression of pallial patterning genes." Doctoral thesis, SISSA, 2012. http://hdl.handle.net/20.500.11767/3924.

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In this study, we assayed the capability of four genes implicated in embryonic specification of the cortico-cerebral field, Foxg1, Pax6, Emx2 and Lhx2, to reprogramm mouse embryonic fibroblasts toward neural identities. Lentivirus-mediated, TetON-dependent overexpression of Pax6 and Foxg1 transgenes specifically activated the neural stem cell (NSC) reporter Sox1-EGFP in a substantial fraction of engineered cells. The efficiency of this process was enhanced up to ten times by simultaneous inactivation of Trp53 and co-administration of a specific drug mix inhibiting HDACs, H3K27-HMTase and H3K4

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10

Kole, Denis. "Role of Fibroblast Growth Factor 2 in Maintenance of Multipotency in Human Dermal Fibroblasts Treated with Xenopus Laevis Egg Extract Fractions." Digital WPI, 2014. https://digitalcommons.wpi.edu/etd-dissertations/207.

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Current usage of human embryonic stem cells (hES) and induced pluripotent stem cells (iPS) in clinical therapies and personalized medicine are limited as a result of ethical, technical and medical problems that arise from isolation and generation of these cells. Isolation of hES cells faces ethical problems associated with their derivation from human pre-implantation embryos. The most controversial aspect of hES cell isolation targets the generation of autologous hES cell lines which requires the transfer of a somatic-cell nucleus from the patient to an enucleated oocyte. While already establi

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11

Villafranca, Locher Maria Cristina. "Fusion of bovine fibroblasts to mouse embryonic stem cells: a model to study nuclear reprogramming." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/82864.

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The cells from the inner cell mass (ICM) of an early embryo have the potential to differentiate into all the different cell types present in an adult organism. Cells from the ICM can be isolated and cultured in vitro, becoming embryonic stem cells (ESCs). ESCs have several properties that make them unique: they are unspecialized, can self-renew indefinitely in culture, and given the appropriate cues can differentiate into cells from all three germ layers (ecto-, meso-, and endoderm), including the germline, both in vivo and in vitro. Induced pluripotent stem cells (iPSCs) can be generated from

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12

Yang, Chao-Shun. "Molecular Landscape of Induced Reprogramming: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/698.

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Recent breakthroughs in creating induced pluripotent stem cells (iPS cells) provide alternative means to obtain embryonic stem (ES) cell-like cells without destroying embryos by introducing four reprogramming factors (Oct3/4, Sox2, and Klf4/c-Myc or Nanog/Lin28) into somatic cells. However, the molecular basis of reprogramming is largely unknown. To address this question, we employed microRNAs, small molecules, and conducted genome-wide RNAi screen, to investigate the regulatory mechanisms of reprogramming. First we showed that depleting miR-21 and miR-29a enhances reprogramming in mouse embry

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13

Yang, Chao-Shun. "Molecular Landscape of Induced Reprogramming: A Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/698.

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Анотація:

Recent breakthroughs in creating induced pluripotent stem cells (iPS cells) provide alternative means to obtain embryonic stem (ES) cell-like cells without destroying embryos by introducing four reprogramming factors (Oct3/4, Sox2, and Klf4/c-Myc or Nanog/Lin28) into somatic cells. However, the molecular basis of reprogramming is largely unknown. To address this question, we employed microRNAs, small molecules, and conducted genome-wide RNAi screen, to investigate the regulatory mechanisms of reprogramming. First we showed that depleting miR-21 and miR-29a enhances reprogramming in mouse embry

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14

Guastali, Midyan Daroz. "Reprogramação de fibroblastos de pele e células do cordão umbilical por meio de plasmídeos virais e transposons na produção de iPS equinas." Botucatu, 2016. http://hdl.handle.net/11449/147075.

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Orientador: Fernanda da Cruz Landim<br>Resumo: As pesquisas envolvendo a biologia das células-tronco abordam um amplo espectro de fenômenos, que vão desde o nível tecidual e celular, até o seu uso em terapias celulares. Esta crescente atenção sugere que é necessário estudar conceitos básicos da biologia das células-tronco para compreender completamente os processos de diferenciação funcional. Desta forma, o instrumento da reprogramação celular por meio da manipulação gênica fornece subsídios para melhor compreender os processos de renovação e diferenciação que constituem as características fun

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15

Lucas, Emma S. "Defining global DNA methylation differences betwen embryonic stem cells and fibroblasts for exploitation in Epigenetic reprogramming in vitro." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519395.

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16

FIRRITO, CLAUDIA. "Targeted Gene Correction and Reprogramming of SCID-X1 Fibroblasts to Rescue IL2RG Expression in iPSC-derived Hematopoietic Cells." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/94656.

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La terapia genica basata sull’utilizzo di vettori integranti è stata già applicata con successo per la cura di varie malattie genetiche come le malattie da accumulo lisosomiale (LSD), la beta-talassemia (β-Thal) e le immunodeficienze primarie (PID). L’immunodeficienza combinata grave legata al cromosoma X (SCID-X1) è una malattia monogenica letale causata da mutazioni del gene codificante la catena comune gamma del recettore per l’interleuchina 2 (IL2RG). I primi studi clinici per la SCID-X1 hanno mostrato il potenziale terapeutico della terapia genica basata su vettori integranti, risultando

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17

Chang, Chia-Wei. "Polycistronic lentiviral vector for hit and run reprogramming of mouse and human somatic cells to induced pluripotent stem cell." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/changc.pdf.

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18

Preskey, David Alexander. "An mRNA-reprogramming method with improved kinetics and efficiency and the successful transdifferentiation of human fibroblasts using modified mRNA." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/18242/.

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Induced pluripotent stem (iPS) cells have the potential to generate a wide array of cell types from multiple lineages that enable us to explore the mechanisms that are involved in the conversion of cell states. The reprogramming process that generates iPS cells is complex, but since its discovery, technical advancements and improvements in the methodology have improved the speed and efficiency of generating integration-free, clinically relevant iPS cells. However, despite improvements, the mechanisms of reprogramming are not fully understood and so the process remains largely inefficient and s

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19

Li, Zhonghan. "Dissecting Somatic Cell Reprogramming by MicroRNAs and Small Molecules: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/607.

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Somatic cells could be reprogrammed into an ES-like state called induced pluripotent stem cells (iPSCs) by expression of four transcriptional factors: Oct4, Sox2, Klf4 and cMyc. iPSCs have full potentials to generate cells of all lineages and have become a valuable tool to understand human development and disease pathogenesis. However, reprogramming process suffers from extremely low efficiency and the molecular mechanism remains poorly understood. This dissertation is focused on studying the role of small non-coding RNAs (microRNAs) and kinases during the reprogramming process in order to und

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20

Dubé, Delphine. "Différence dans la capacité de fibroblastes à être reprogrammés par le cytoplasme de l'ovocyte : étude d'une situation différentielle chez le bovin." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS252.

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La reprogrammation, qui est la réversion d’un noyau d’un état somatique vers un état moins différencié, constitue un enjeu majeur pour la thérapie cellulaire. Cependant, les mécanismes initiaux qui président à la reprogrammation restent mal connus. Le transfert nucléaire (clonage) met à profit les propriétés de reprogrammation uniques du cytoplasme ovocytaire, et constitue une approche expérimentale intéressante pour analyser ces processus. Le but de cette thèse est d’étudier la différence de capacité de cellules fibroblastiques à être reprogrammées efficacement, en tirant partie d’une situati

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21

Alves, André Filipe Baltazar. "Cited2 in mouse embryonic fibroblasts reprogramming." Master's thesis, 2014. http://hdl.handle.net/10400.1/8353.

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Dissertação de Mestrado, Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, 2014<br>Células diferenciadas podem ser reprogramadas de modo a voltarem a ser pluripotentes e se transformarem em outros tipos de células através da inserção de factores específicos. No entanto a reprogramação de células somáticas de modo a se obter células estaminais pluripotentes induzidas (iPS), tem um tempo de reprogramação é relativamente longo, a eficiência da reprogramação ainda é relativamente baixa, alguns dos factores de pluripotencia que são usados para este proces

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22

Rohanisarvestani, Leili. "Integration-free mRNA reprogramming of human fibroblasts: The study of aging upon reprogramming." Doctoral thesis, 2014. https://ul.qucosa.de/id/qucosa%3A12076.

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The ability to reprogram adult somatic cells into induced pluripotent stem (iPS) cells could provide a valuable implement for in vitro disease modeling and drug discovery. More importantly, they may potentially serve as an unlimited source of cells for regenerative medicine. However, most of the iPS cells have been generated by retroviral vectors, and therefore they carry the risk of viral integration into the host genome. This problem prevents their use for clinical applications and regenerative medicine. mRNA-mediated delivery of reprogramming factors is an alternative approach for cellular

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23

Rosa, Fábio Alexandre Fiúza. "Direct Reprogramming of Fibroblasts to Dendritic Cells for Immunotherapy." Master's thesis, 2016. http://hdl.handle.net/10316/33773.

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ROSA, Fábio Alexandre Fiúza - Direct Reprogramming of Fibroblasts to Dendritic Cells for Immunotherapy. Coimbra : [s.n.], 2016. Dissertação de Mestrado.<br>The maintenance of cellular identity relies on stable and complex gene regulatory networks. However, several studies have shown that cell fate can be reversed or modified by defined sets of lineage specific Transcription Factors (TFs). The process of direct cellular reprogramming holds promise for the generation of autologous cells for regenerative medicine. In the immunotherapy field, the use of immune modulatory cells enables the manipul

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24

Tsai, Stephanie, and 蔡迪姍. "Stem Cell Extract Promotes the Reprogramming of Human Gingival Fibroblasts." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/98254481414271105419.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>101<br>Induced pluripotent stem cell (iPS), generated from somatic cells by the four transcription factors, has been startling development of reprogramming technology. Since the integration of vectors is not fully predictable, a flood of studies have been publishing, including protein based-DNA free method. This method required abundant protein extracts, which were often collected by embryonic stem cells or teratocarcinoma, were harder to be applied clinically. Human cord blood has been established as a stable and potential source of mesenchymal stromal cells (cbMSC

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25

Santos, Ana Raquel Pereira. "The role of LSD1/CoREST during hemogenic reprogramming." Master's thesis, 2018. http://hdl.handle.net/10316/82432.

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Dissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina<br>As células estaminais hematopoiéticas (HSCs) são capazes de se auto-renovar e diferenciar em todos os tipos de células sanguíneas. Estas características fazem com que a transplantação de HSCs seja o principal tratamento contra doenças hematológicas. A incompatibilidade entre dador-paciente e o número insuficiente de HSCs que são obtidas para transplantação limitam o sucesso deste tipo de terapia celular. De forma a ultrapassar estas limitações, a expansão destas células in vitro seria a solução, mas este p

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26

Oliveira, Catarina Alexandra Grilo de. "Reprogramming of fibroblasts intoinduced Pluripotent Stem Cells – iPSC : hepatitis C – challenges and progress." Master's thesis, 2013. http://hdl.handle.net/10451/29589.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2013<br>Hepatitis C is a liver disease that results from an infection by the Hepatitis C virus. It can range between severe to moderate illness, with variable time. Today, the most infected people are associate with drugs and injectable material. Until 1992, an individual was mostly infected by blood transfusions or organ transplants. This work reflects, therefore, the attempt to develop different strategies to the detailed study of hepatitis C virus, using a novel cellular strategy. Th

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27

LUO, PEI-WEN, and 羅佩玟. "Optogenetic modulation and reprogramming of bacteriorhodopsin-transfected human fibroblasts on self-assembled fullerene C60 nanosheets." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/544u23.

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碩士<br>國立臺灣大學<br>高分子科學與工程學研究所<br>107<br>Fullerenes have the unique biocompatibility and photoelectric properties and are candidate materials for biomedical applications. Several cell membrane proteins in nature such as bacteriorhodopsin also have photoelectric properties. Highly expressible bacteriorhodopsin (HEBR) is a novel light-sensitive opsin that has the potential to trigger neural activities through optogenetic modulation. In this study, we delivered HEBR plasmids to human fibroblasts and exposed the cells to C60 fullerene self-assembled two-dimensional nanosheets. Results showed that th

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28

Correia, Paula Magda Teixeira. "Exploiting the role of long non-coding RNAs in the direct conversion of fibroblasts into functional cardiomyocytes." Master's thesis, 2020. http://hdl.handle.net/10773/29325.

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Heart disease is one of the leading causes of mortality in developed countries. The associated pathology is typically characterized by the loss of cardiomyocytes that leads, eventually, to heart failure. Presently, there are many promising strategies for cardiac regeneration. Direct cardiac reprogramming is becoming known as a novel therapeutic approach to regenerate injured hearts. Direct cardiac reprogramming is a simple and quick process however, the molecular mechanisms of cardiac reprogramming and cardiomyocyte-like cells functional maturation remain to be understood. Direct cardiac repr

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29

Hao, Ru [Verfasser]. "Reprogramming of mesenchymal stem cells and adult fibroblasts following nuclear transfer in rabbits / by Ru Hao." 2008. http://d-nb.info/993277586/34.

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30

Ho, Lin, and 何琳. "Cell reprogramming by 3D bioprinting of human fibroblasts in polyurethane hydrogel for fabrication of neural-like constructs." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/b6n7g4.

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碩士<br>國立臺灣大學<br>高分子科學與工程學研究所<br>106<br>3D bioprinting is a technique which enables the direct printing of biodegradable materials with cells into 3D tissue. So far there is no cell reprogramming in situ performed with the 3D bioprinting process. Forkhead box D3 (FoxD3) is a transcription factor and neural crest marker, which was reported to reprogram human fibroblasts into neural crest stem-like cells. In this study, we synthesized a new biodegradable thermoresponsive waterborne polyurethane (PU) gel as a bioink. FoxD3 plasmids and human fibroblasts were co-extruded with the PU hydrogel throug

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31

Adler, Andrew Frederick. "Non-viral Transfection and Direct Reprogramming of Fibroblasts to Neurons and Glia: Importance of Physical and Chemical Microenvironments." Diss., 2014. http://hdl.handle.net/10161/9048.

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<p>The recent discovery that fibroblasts can be reprogrammed directly to functional neurons with lentivirus has reinvigorated the belief that autologous human cell therapies against many neurodegenerative diseases may be achievable in the near future. To increase the clinical translatability of this approach, we have developed a technique to perform this direct conversion without the use of virus. We transfected fibroblasts with plasmids condensed into non-viral nanoparticulate carriers with a bioerodible peptidomimetic polymer, pCBA-ABOL. Gene delivery with pCBA-ABOL was exceptionally effec

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32

Carfora, Antonia. "L'eterogeneità dei fibroblasti dermici come fattore in grado di condizionare l'efficacia della riprogrammazione cellulare. Dermal fibroblasts heterogeneity as a major factor influencing the efficiency of cell reprogramming." Tesi di dottorato, 2018. http://www.fedoa.unina.it/12530/1/carfora_antonia_31.pdf.

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Fibroblasts are a heterogeneous cell population as testified by the absence of specific markers and by their documented retention of positional memory. Fibroblasts have recently gained much attention as they are the adult somatic cell most commonly used for reprogramming to induced pluripotent stem cells (iPSCs). iPSCs are somatic cells genetically reprogrammed to a pluripotent state that makes them resemble embryonic stem cells (ESCs). iPSCs are a very promising tool for regenerative medicine because of their autologous origin and their ability to differentiate towards cell of all three germ

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33

Azenha, Cláudia de Jesus. "Defining Transcriptional Networks Underlying Dendritic Cell Heterogeneity Using Direct Cellular Reprogramming." Master's thesis, 2018. http://hdl.handle.net/10316/82431.

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Dissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina<br>Estratégias de reprogramação celular têm evidenciado a flexibilidade do destino celulare, através de fatores de transcrição (FTs) específicos dos tipos celulares para converter células somáticas em pluripotentes. A reprogramação direta de um tipo de célula diferenciada em outr,o também foi demonstrada e explorada para elucidar os mecanismos de biologia celular e para fins de medicina regenerativa. Recentemente, demonstrámos que células dendríticas (CDs) apresentadoras de antigénios, podem ser reprogramada

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34

Liao, Juan-chi, and 廖專琪. "Ultrasound enhances mouse fibroblast Ultrasound enhances mouse fibroblast reprogramming to induced pluripotent stem cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/9at43n.

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碩士<br>國立高雄大學<br>生物科技研究所<br>99<br>The somatic cell could reprogram to induced pluripotent stem cell (iPSC) by gene transfection vector. The characters of iPS cells are like embryonic stem cells (ESC), they have the same gene expression and life characteristic, include self-renew and differentiate to three germ layers. The preparation of iPSC is by lentiviral vector, but the transfect rate of is only 0.1 to 1%. Ultrasound is a new method of gene transfection. When ultrasound transmits energy in fluid, it could cause cavitations and damage the cell membrane. Therefore, ultrasound could enhance th

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Kang, Ching-Hsun, and 康景勛. "Reprogramming the adult skin fibroblast cells with embryonic stem cell extract." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/26636879067512663805.

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碩士<br>國立成功大學<br>生物科技研究所碩博士班<br>94<br>Nuclear reprogramming is defined as altering the gene activity of differentiated cells to express the characteristics and function of different lineage, even resume their pluripotency. Several researches have demonstrated that nuclear reprogramming is possible. Nuclear transfer with somatic cells had proven to be able to give rise to cloning animals and derivation of embryonic stem cells. Induction of plasticity of adult stem cells could promote somatic cells to trans-differentiate into other cell lineages. 　After increasing permeability of the plasma membr

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Huang, Yao-De, and 黃耀德. "Roles of EpCAM and CLDN-7 in reprogramming mouse fibroblast into induced pluripotent stem cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/47656085868312770304.

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碩士<br>國立臺灣海洋大學<br>生物科技研究所<br>98<br>Epithelial cell adhesion molecule (EpCAM) is a cell adhesion molecule and a potential target for therapeutic antibodies. Recently, EpCAM has been shown to regulate tumor cell proliferation by its nucleocytoplasmic intracellular domain fragment (ICD). EpCAM intracellular domain (EpICD) activates C terminal myelocytomatosis oncogene (c-Myc) in nucleus by Wnt signal pathway. On the other hand, the complex of EpCAM and the tight junction protein claudin-7 (CLDN-7) would promote tumorigenicity and accelerates tumor growth. We observed that EpCAM and CLDN-7 express

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Santana, Miguel Torres. "Enhancing reprogramming and transdifferentiation through long non-coding RNAs." Master's thesis, 2017. http://hdl.handle.net/10451/31607.

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Tese de mestrado, Engenharia Biomédica e Biofísica (Engenharia Clínica e Instrumentação Médica) Universidade de Lisboa, Faculdade de Ciências, 2017<br>Foi recentemente desenvolvido um novo método revolucionário capaz de reprogramar fibroblastos em células pluripotentes induzidas através da expressão de 4 fatores de transcrição (Oct4, Sox2, Klf4 e c-Myc). A reprogramação de fibroblastos em células pluripotentes induzidas (iPSC) foi um grande avanço científico com possíveis aplicações clínicas e fins terapêuticos, no entanto, à medida que as células diferenciadas (células somáticas) vão envelhec

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Steward, Melissa Mary. "The Direct Reprogramming of Somatic Cells: Establishment of a Novel System for Photoreceptor Derivation." 2013. http://hdl.handle.net/1805/3455.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Photoreceptors are a class of sensory neuronal cells that are deleteriously affected in many disorders and injuries of the visual system. Significant injury or loss of these cells often results in a partial or complete loss of vision. While previous studies have determined many necessary components of the gene regulatory network governing the establishment, development, and maintenance of these cells, the necessary and sufficient profile and timecourse of gene expression and/or silencing has yet to be elucidated. Arduous protocols do

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