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Автор: Grafiati
Опубліковано: 10 грудня 2022
Оновлено: 29 січня 2023

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1

Edib, Zobaida, Yasmin Jayasinghe, Martha Hickey, Lesley Stafford, Richard A. Anderson, H. Irene Su, Kate Stern, et al. "Exploring the facilitators and barriers to using an online infertility risk prediction tool (FoRECAsT) for young women with breast cancer: a qualitative study protocol." BMJ Open 10, no. 2 (February 2020): e033669. http://dx.doi.org/10.1136/bmjopen-2019-033669.

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IntroductionAs cancer treatments may impact on fertility, a high priority for young patients with breast cancer is access to evidence-based, personalised information for them and their healthcare providers to guide treatment and fertility-related decisions prior to cancer treatment. Current tools to predict fertility outcomes after breast cancer treatments are imprecise and do not offer individualised prediction. To address the gap, we are developing a novel personalised infertility risk prediction tool (FoRECAsT) for premenopausal patients with breast cancer that considers current reproductive status, planned chemotherapy and adjuvant endocrine therapy to determine likely post-treatment infertility. The aim of this study is to explore the feasibility of implementing this FoRECAsT tool into clinical practice by exploring the barriers and facilitators of its use among patients and healthcare providers.Methods and analysisA cross-sectional exploratory study is being conducted using semistructured in-depth telephone interviews with 15–20 participants each from the following groups: (1) premenopausal patients with breast cancer younger than 40, diagnosed within last 5 years, (2) breast surgeons, (3) breast medical oncologists, (4) breast care nurses (5) fertility specialists and (6) fertility preservation nurses. Patients with breast cancer are being recruited from the joint Breast Service of three affiliated institutions of Victorian Comprehensive Cancer Centre in Melbourne, Australia—Peter MacCallum Cancer Centre, Royal Melbourne Hospital and Royal Women’s Hospital, and clinicians are being recruited from across Australia. Interviews are being audio recorded, transcribed verbatim and imported into qualitative data analysis software to facilitate data management and analyses.Ethics and disseminationThe study protocol has been approved by Melbourne Health Human Research Ethics Committee, Australia (HREC number: 2017.163). Confidentiality and privacy are maintained at every stage of the study. Findings will be disseminated through peer-reviewed scholarly and scientific journals, national and international conference presentations, social media, broadcast media, print media, internet and various community/stakeholder engagement activities.
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2

Peate, Michelle, Sherine Sandhu, Sabine Braat, Roger Hart, Robert Norman, Anna Parle, Raelia Lew, and Martha Hickey. "Randomized control trial of a decision aid for women considering elective egg freezing: The Eggsurance study protocol." Women's Health 18 (January 2022): 174550572211396. http://dx.doi.org/10.1177/17455057221139673.

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Background: Uptake of elective egg freezing has increased globally. The decision to freeze eggs is complex, and detailed, unbiased information is needed. To address this, we developed an online Decision Aid for women considering elective egg freezing. Decision Aids are the standard of care to support complex health decisions. Objectives: This study will measure the impact of the Decision Aid on decision-making (e.g. decisional conflict, engagement in decision-making, distress, and decision delay) and decision quality (e.g. knowledge, level of informed choice, and regret). Methods and Analysis: A single-blinded two-arm parallel-group randomized controlled trial. Women considering elective egg freezing will be recruited using social media, newsletters, and fertility clinics. Data will be collected at baseline (recruitment), 6-month, and 12-month post-randomization. The primary hypothesis is that the intervention (Decision Aid plus Victorian Assisted Reproductive Technology Authority website) will reduce decisional conflict (measured using the Decisional Conflict Scale) at 12 months more than control (Victorian Assisted Reproductive Technology Authority website only). Secondary outcomes include engagement in decision-making (Perceived Involvement in Care Scale), distress (Depression, Anxiety, and Stress Scale), decision delay, knowledge, informed choice (Multi-dimensional Measure of Informed Choice), and decisional regret (Decisional Regret Scale). Ethics: The study was approved by the University of Melbourne Human Research Ethics Committee (Ethics ID: 2056457). Informed consent will be obtained from all participants prior to enrolment. Discussion: This is the first international randomized controlled trial that aims to investigate the effect of an elective egg freezing Decision Aid on decision-related outcomes (e.g. decisional conflict, informed choice, and regret). It is anticipated that participants who receive the Decision Aid will have better decision and health outcomes. Registration details: ACTRN12620001032943: Comparing different information resources on the process and quality of decision-making in women considering elective egg freezing.
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3

Land, Nicole, Catherine Hamm, Sherri-Lynn Yazbeck, Miriam Brown, Ildikó Danis, and Narda Nelson. "Doing pedagogical intentions with Facetiming Common Worlds (and Donna Haraway)." Global Studies of Childhood 10, no. 2 (January 27, 2020): 131–44. http://dx.doi.org/10.1177/2043610618817318.

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Working with stories of children’s relationships with place and technologies from an early childhood education pedagogical inquiry research project in Melbourne, Australia and Victoria, Canada, this article takes up the concept of “pedagogical intentions” to consider how educators and researchers might cultivate intentional teaching practices relevant to the complex worlds we inherit with children. We think with a common worlds pedagogies approach to extend conceptualizations of intentional teaching held in dominant Euro-Western early learning frameworks in Melbourne and Victoria. After situating our understanding of pedagogical intentionality as an ongoing, purposeful, answerable practice of shaping and caring with everyday pedagogical relationships, we share three stories of how we activate our Donna Haraway–inspired intentions with children. By questioning how our pedagogical intentions inform our work, we assert that sharing and putting at risk our intentions is a necessary practice for thinking collectively with children, more-than-human others, and technologies within early childhood education.
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4

Fennessy, Kathleen M. "'Industrial Instruction' for the 'Industrious Classes': Founding the Industrial and Technological Museum, Melbourne." Historical Records of Australian Science 16, no. 1 (2005): 45. http://dx.doi.org/10.1071/hr05003.

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This paper examines the movement to foster scientific and technical learning in the colony of Victoria during the 1860s. It discusses how the concept of a public museum for 'industrial' and 'technological' instruction emerged, and analyses the events leading to the establishment of the Industrial and Technological Museum, Victoria's first public institution for educating the people in applied science.
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5

Howes, Hilary. "Lothar Becker’s contributions to anthropology." Historical Records of Australian Science 30, no. 2 (2019): 138. http://dx.doi.org/10.1071/hr19004.

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Warning Readers of this article are warned that it may contain terms, descriptions and opinions that are culturally sensitive and/or offensive to Aboriginal and Torres Strait Islanders. Silesian traveller-naturalist Lothar Becker’s two visits to Victoria in 1849–52 and 1855–65 brought him into contact with Aboriginal people living in Western Victoria, Melbourne, the Murray River at Albury, and Gippsland. His travels took him to areas now recognised as the traditional lands of the Gunaikurnai, Wathaurung, Wiradjuri and Wurundjeri peoples. Becker’s publications include scattered observations on Aboriginal appearance, lifeways, diet, skills, and beliefs. Although these observations were limited by his inability to speak any Aboriginal languages and coloured by his assumptions about the inferiority of Aboriginal culture, they nevertheless document small but significant fragments of what has recently been termed ‘Aboriginal Biocultural Knowledge’.
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6

Howes, Hilary. "Corrigendum to: Lothar Becker’s contributions to anthropology." Historical Records of Australian Science 30, no. 2 (2019): 199. http://dx.doi.org/10.1071/hr19004_co.

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Анотація:
WarningReaders of this article are warned that it may contain terms, descriptions and opinions that are culturally sensitive and/or offensive to Aboriginal and Torres Strait Islanders. Silesian traveller-naturalist Lothar Becker's two visits to Victoria in 1849–52 and 1855–65 brought him into contact with Aboriginal people living in Western Victoria, Melbourne, the Murray River at Albury, and Gippsland. His travels took him to areas now recognised as the traditional lands of the Gunaikurnai, Wathaurung, Wiradjuri and Wurundjeri peoples. Becker's publications include scattered observations on Aboriginal appearance, lifeways, diet, skills, and beliefs. Although these observations were limited by his inability to speak any Aboriginal languages and coloured by his assumptions about the inferiority of Aboriginal culture, they nevertheless document small but significant fragments of what has recently been termed ‘Aboriginal Biocultural Knowledge'.
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7

Jakubowicz, Andrew, and Devaki Monani. "Mapping Progress : Human Rights and International Students in Australia." Cosmopolitan Civil Societies: An Interdisciplinary Journal 7, no. 3 (December 1, 2015): 61–80. http://dx.doi.org/10.5130/ccs.v7i3.4473.

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The rapid growth in international student numbers in Australia in the first decade of the 2000s was accompanied by a series of public crises. The most important of these was the outbreak in Melbourne Victoria and elsewhere of physical attacks on the students. Investigations at the time also pointed to cases of gross exploitation, an array of threats that severely compromised their human rights. This paper reviews and pursues the outcomes of a report prepared by the authors in 2010 for Universities Australia and the Human Rights Commission. The report reviewed social science research and proposed a series of priorities for human rights interventions that were part of the Human Rights Commission’s considerations. New activity, following the innovation of having international students specifically considered by the Human Rights Commission, points to initiatives that have not fully addressed the wide range of questions at state.
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8

Rae, Ian D. "David Orme Masson, the Periodic Classification of the Elements and His ‘Flap’ Model of the Periodic Table." Historical Records of Australian Science 24, no. 1 (2013): 40. http://dx.doi.org/10.1071/hr12018.

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In the early 1890s, David Orme Masson, Professor of Chemistry at the University of Melbourne, invented a new way to display the periodic table of the elements, in which the transition elements were arranged on a flap that projected from the plane containing the main group elements. He shared the idea with his mentor, Sir William Ramsay, at University College London, who published a similar model in his 1896 book. The ?flap' arrangement was an outcome of Masson's research interest in the periodic classification of the elements, to which he also made contributions in the 1890s about the placement of hydrogen and suggested to Ramsay that a new main group was needed to accommodate the rare gases such as helium and argon then being discovered in London. Although it was not widely adopted elsewhere, Masson's ?flap' model was a research and a teaching tool that was used at the University of Melbourne and in school chemistry teaching in Victoria for over half a century.
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9

Willis, J. B. "Three Little Companies — the Birth of a Major Australian Scientific Instrument Industry." Historical Records of Australian Science 14, no. 4 (2002): 403. http://dx.doi.org/10.1071/hr03007.

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The atomic absorption spectrometer revolutionized chemical analysis in the 1960s. Invented by Alan Walsh of the CSIRO Division of Chemical Physics, its manufacture in Australia began with three small Melbourne companies making the necessary optical, mechanical and electronic components. Subsequently, one of these companies, Techtron Pty Ltd, made a complete instrument and became a major supplier to the international market. Techtron expanded rapidly and in 1967 was sold to a large US company, Varian Associates Inc., which still operates as Varian Australia Pty Ltd and manufactures atomic absorption spectrometers and other scientific instruments at Mulgrave, Victoria.
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10

Cohn, Helen M. "Watch Dog over the Herbarium: Alfred Ewart, Victorian Government Botanist 1906 - 1921." Historical Records of Australian Science 16, no. 2 (2005): 139. http://dx.doi.org/10.1071/hr05009.

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Alfred Ewart was Government Botanist in the service of the Victorian Government from February 1906 to February 1921. He was concurrently foundation Professor of Botany at the University of Melbourne, both positions being part-time. As Government Botanist he was in charge of the National Herbarium of Victoria, which had fallen into a slump after the death of the first Government Botanist, Ferdinand von Mueller, in 1896. Ewart was determined to restore the Herbarium to its former position as a leading centre of research on the Victorian and indeed the Australian flora. In doing so he enlisted the aid of the many capable botanists who were members of the Field Naturalists' Club of Victoria. The Herbarium being in the Department of Agriculture, Ewart had duties in relation to the business of that Department. These had mainly to do with weeds, impure seeds and providing advice to departmental officers. Of particular importance was his taxonomic work as Government Botanist. He published a series of papers and books on the flora of Victoria and the Northern Territory, and engaged in debates with colleagues both interstate and overseas. Ewart ceased to be Government Botanist when the professorship was made a full-time appointment in response to increased teaching loads.
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11

E. Whiting, Amy, and Kelly K. Miller. "Examining the Living with Possums policy in Victoria, Australia: community knowledge, support and compliance." Pacific Conservation Biology 14, no. 3 (2008): 169. http://dx.doi.org/10.1071/pc080169.

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Studying the human dimensions of wildlife management issues is now considered to be an essential component of wildlife research. This study examined the Living with Possums policy in Victoria, Australia, in terms of the policy?s success in educating the community and ensuring community compliance. Postal surveys and telephone interviews were conducted across three samples from Greater Melbourne. These samples included people who had experiences with possums on their property (n = 340), veterinary clinics (n = 45) and the general public (n = 103). Significant levels of non-compliance were uncovered, highlighting the need for a renewed public education campaign to take place along with a continued interest in this issue from government agencies and councils. The study also revealed discrepancies between the policy and public preferences for possum management, suggesting that a shift in the recommended management technique may be warranted.
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12

Gillbank, Linden. "University Botany in Colonial Victoria: Frederick McCoy's Botanical Classes and Collections at the University of Melbourne." Historical Records of Australian Science 19, no. 1 (2008): 53. http://dx.doi.org/10.1071/hr08002.

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Botany was part of the broad intellectual territory of one of the University of Melbourne's four foundation chairs. From his appointment in 1854 until his death in 1899, Frederick McCoy was the Professor of Natural Science and, for most of that time, also honorary Director of the Colony of Victoria's National Museum. McCoy gained ideas about botany and botanic gardens and museums while studying and working at the University of Cambridge, where he attended Professor John Stevens Henslow's botany lectures in 1847. With help from Henslow and Victoria's Government Botanist, Ferdinand Mueller, McCoy acquired botanical collections and developed a class (system) garden at the University of Melbourne, where he taught botany to arts and medical students from 1863 until the establishment of the science degree and arrival of the Professor of Biology in 1887 left him only a rarely-taken botanical subject.
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13

Rae, Ian D. "Radiocarbon Dating at the Museum of Applied Science Victoria 1952–70: a Pioneer Venture." Historical Records of Australian Science 29, no. 1 (2018): 14. http://dx.doi.org/10.1071/hr17019.

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The Museum of Applied Science in Melbourne committed in the earlier 1950s to the development of a radiocarbon dating laboratory that would provide dates for carbonaceous material obtained by archaeologists and anthropologists. Progress through the 1950s was very slow due to under-resourcing and -staffing, but Victorian researchers obtained results by sending material to New Zealand and the USA for dating. The laboratory was officially opened in 1961 but few dates emerged. While the process for obtaining carbon dioxide from carbonaceous material, operated by chemist Anne Bermingham, was satisfactory, the apparatus for counting the carbon-14 decompositions, built by her and a series of electronics technicians was never satisfactory. The radiocarbon laboratorywas closed at the end of 1970, bywhich time several other dating services had opened in Australia.
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14

Ngai, Mae M., and Sophie Loy-Wilson. "Thinking Labor Rights through the Coolie Question." International Labor and Working-Class History 91 (2017): 5–7. http://dx.doi.org/10.1017/s0147547916000399.

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In 2014 the conservative Australian Institute of Public Affairs called for the abolition of the minimum wage—at the time AU$16.87, the highest in the industrial world and twice that of the United States. The Australian minimum, enacted in Victoria in 1896, was the first in the world. Other nations copied it, and the International Labor Organization inscribed it as an international convention in 1928. Responding to calls for its abolition, University of Melbourne historian Marilyn Lake reminded Australians that the minimum wage was a “symbol of Australian values.” Envisioned as a “living wage, sufficient to meet the variety of needs of a person living in a civilized community … [it] recognized workers as human beings and equal citizens,” she wrote.
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15

Garrett, Claire, and H. W. Gordon Baker. "A new fully automated system for the morphometric analysis of human sperm heads**Supported by grants 890959 from the National Health and Medical Research Council of Australia and 9320 from the Research Committee of the Royal Women’s Hospital, Melbourne, Victoria, Australia, and by Melbourne IVF, Melbourne, Victoria, Australia." Fertility and Sterility 63, no. 6 (June 1995): 1306–17. http://dx.doi.org/10.1016/s0015-0282(16)57616-x.

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16

Ngo, Phuong Linh. "THE METHANE UPTAKE CAPACITY OF SOIL GARDEN." Vietnam Journal of Science and Technology 55, no. 4C (March 24, 2018): 122. http://dx.doi.org/10.15625/2525-2518/55/4c/12140.

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Aerobic CH4 oxidation through methanotrophic bacteria is the only terrestrial sink and the only sink that can be altered directly or indirectly by human so far. However, the capacity of this sink is highly variable in different ecosystems depending on four key factors which are soil diffusivity, soil temperature, soil nitrogen status and soil moisture. While many studies in Australia experience the significant inverse correlation between soil moisture and CH4 flux magnitude in temperate forests in Victoria and New South Wales, there is a lack of research about the methane uptake capacity of garden soil. Consequently, we hypothesise that there is a similar pattern of CH4 uptake by garden soil. The aim of this study is to determine the capacity of CH4 oxidation along the soil garden profile. Our study was conducted at a native garden in Burnley Campus of the University of Melbourne, Victoria, Australia. Our results show three main findings. Firstly, garden soil can become a significant sink of CH4. Secondly, there was a significant correlation between soil moisture and the soil CH4 uptake rates. Finally, there was an expansion of the CH4 oxidation layer to deeper soil layers as the soil dries at the surface.
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17

LANTSBERG, Daniel, Yossi MIZRACHI, and Darren KATZ. "Micro-TESE Outcomes for Non-Obstructive Azoospermia — The First Australian Series." Fertility & Reproduction 04, no. 03n04 (September 2022): 140. http://dx.doi.org/10.1142/s2661318222740528.

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Background: Micro-dissection testicular sperm extraction (micro-TESE) for non-obstructive azoospermia (NOA) was shown to achieve the best sperm retrieval rate (SRR) compared to other techniques. However, to date there is no large series of published Australian data. Aim: To study the incidence and predicting factors of successful sperm extraction in men with NOA undergoing micro-TESE in Victoria. Method: We retrospectively analyzed the clinical data of all consecutive patients with confirmed NOA who were treated between August 2014 and April 2020 in a single medical centre in Melbourne, Victoria. None were excluded. Patients underwent micro-TESE and upon a successful sperm retrieval, sperm was either frozen for fertility preservation or used fresh for ICSI. Results: During the study period, 85 men with NOA underwent micro-TESE in our centre. The overall sperm retrieval rate (SRR) was 61.2% (52/85). All patients with a history of surgically treated cryptorchidism or childhood diseases had a successful sperm retrieval. Patients with Kleinfelter syndrome had a 75% SRR. Patients with Idiopathic NOA and patients with a history of chemotherapy had a 50% and 40% SRR, respectively. Among the different types of testicular pathology, the highest SRR was found in men with complete hyalinization (100%). Hypospermatogenesis was associated with a high SRR of 93.3%, while Sertoli-cell-only histology was associated with only 46.3% SRR. The SRR has significantly increased from 33.3% in 2015-2016 to 73.6% in 2019-2020 (p=0.003). On Multivariate logistic regression analysis, baseline FSH levels <20 IU and history of childhood disease or Klinefelter syndrome were significantly associated with successful sperm retrieval. The cumulative pregnancy rate was 23.7%. Conclusion: This first report from Australia indicates that micro-TESE is an effective method for the treatment of NOA with high SRR and pregnancy rate. Our results can help patient management and counseling.
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18

Young, Jesse T., Cheneal Puljević, Alexander D. Love, Emilia K. Janca, Catherine J. Segan, Donita Baird, Rachel Whiffen, Stan Pappos, Emma Bell, and Stuart A. Kinner. "Staying Quit After Release (SQuARe) trial protocol: a randomised controlled trial of a multicomponent intervention to maintain smoking abstinence after release from smoke-free prisons in Victoria, Australia." BMJ Open 9, no. 6 (June 2019): e027307. http://dx.doi.org/10.1136/bmjopen-2018-027307.

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IntroductionSmoke-free policies have been introduced in prisons internationally. However, high rates of relapse to smoking after release from prison indicate that these policies typically result in short-term smoking cessation only. These high rates of relapse, combined with a lack of investment in relapse prevention, highlight a missed opportunity to improve the health of a population who smoke tobacco at two to six times the rate of the general population. This paper describes the rationale and design of a randomised controlled trial, testing the effectiveness of a caseworker-delivered intervention promoting smoking cessation among former smokers released from smoke-free prisons in Victoria, Australia.Methods and analysisThe multicomponent, brief intervention consists of behavioural counselling, provision of nicotine spray and referral to Quitline and primary care to promote use of government-subsidised smoking cessation pharmacotherapy. The intervention is embedded in routine service delivery and is administered at three time points: one prerelease and two postrelease from prison. Control group participants will receive usual care. Smoking abstinence will be assessed at 1 and 3 months postrelease, and confirmed with carbon monoxide breath testing. Linkage of participant records to survey and routinely collected administrative data will provide further information on postrelease use of health services and prescribed medication.Ethics and disseminationEthical approval has been obtained from the Corrections Victoria Research Committee, the Victorian Department of Justice Human Research Ethics Committee, the Department of Human Services External Request Evaluation Committee and the University of Melbourne Human Research Ethics Committee. Results will be submitted to major international health-focused journals. In case of success, findings will assist policymakers to implement urgently needed interventions promoting the maintenance of prison-initiated smoking abstinence after release, to reduce the health disparities experienced by this marginalised population.Trial registration numberACTRN12618000072213; Pre-results.
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19

Wilkinson, I. "The Battle for the Museum: Frederick mcCoy and the Establishment of the National Museum of Victoria at the University of Melbourne." Historical Records of Australian Science 11, no. 1 (1996): 1. http://dx.doi.org/10.1071/hr9961110001.

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20

Dow, Briony, Betty Haralambous, Courtney Hempton, Susan Hunt, and Diane Calleja. "Evaluation of Alzheimer's Australia Vic Memory Lane Cafés." International Psychogeriatrics 23, no. 2 (July 30, 2010): 246–55. http://dx.doi.org/10.1017/s1041610210001560.

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ABSTRACTBackground: This paper describes the evaluation of the Memory Lane Café service in Victoria, Australia. The Alzheimer's Australia Vic Memory Lane Café model aims to provide a social and educational service to people living with dementia and their carers, family members or friends. Dementia is a serious health issue in Australia, with prevalence estimated at 6.5% of people over 65 years of age. Living with dementia has significant social and psychological ramifications, often negatively affecting quality of life. Social support groups can improve quality of life for people living with dementia.Methods: The evaluation included focus groups and surveys of people with dementia and their carers, staff consultation, service provider interviews, and researcher observation. The Melbourne Health Mental Health Human Research Ethics Committee approved the project. Participants included people with dementia (aged 60 to 93 years, previously enrolled in the Alzheimer's Australia Vic's six-week Living With Memory Loss Program), their carers, friends and/or family members, staff working in the Cafés, and service providers with links to the Cafés.Results: This evaluation found that Memory Lane Cafés promote social inclusion, prevent isolation, and improve the social and emotional well-being of attendees. However, Cafés did not meet the needs of all potential attendees.Conclusions: The evaluation recommended that existing Café services be continued and possibilities for extending the Cafés be explored. Based on evaluation outcomes, the Department of Health Victoria is funding four additional pilot programs in café style support services.
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21

Buultjens, Andrew H., Koen Vandelannoote, Conor J. Meehan, Miriam Eddyani, Bouke C. de Jong, Janet A. M. Fyfe, Maria Globan, et al. "Comparative Genomics Shows ThatMycobacterium ulceransMigration and Expansion Preceded the Rise of Buruli Ulcer in Southeastern Australia." Applied and Environmental Microbiology 84, no. 8 (February 9, 2018): e02612-17. http://dx.doi.org/10.1128/aem.02612-17.

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ABSTRACTSince 2000, cases of the neglected tropical disease Buruli ulcer, caused by infection withMycobacterium ulcerans, have increased 100-fold around Melbourne (population 4.4 million), the capital of Victoria, in temperate southeastern Australia. The reasons for this increase are unclear. Here, we used whole-genome sequence comparisons of 178M. ulceransisolates obtained primarily from human clinical specimens, spanning 70 years, to model the population dynamics of this pathogen from this region. Using phylogeographic and advanced Bayesian phylogenetic approaches, we found that there has been a migration of the pathogen from the east end of the state, beginning in the 1980s, 300 km west to the major human population center around Melbourne. This move was then followed by a significant increase inM. ulceranspopulation size. These analyses inform our thinking around Buruli ulcer transmission and control, indicating thatM. ulceransis introduced to a new environment and then expands, rather than it being from the awakening of a quiescent pathogen reservoir.IMPORTANCEBuruli ulcer is a destructive skin and soft tissue infection caused byMycobacterium ulceransand is characterized by progressive skin ulceration, which can lead to permanent disfigurement and long-term disability. Despite the majority of disease burden occurring in regions of West and central Africa, Buruli ulcer is also becoming increasingly common in southeastern Australia. Major impediments to controlling disease spread are incomplete understandings of the environmental reservoirs and modes of transmission ofM. ulcerans. The significance of our research is that we used genomics to assess the population structure of this pathogen at the Australian continental scale. We have then reconstructed a historical bacterial spread and modeled demographic dynamics to reveal bacterial population expansion across southeastern Australia. These findings provide explanations for the observed epidemiological trends with Buruli ulcer and suggest possible management to control disease spread.
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22

Thompson, Emma J., Miriam H. Beauchamp, Simone J. Darling, Stephen J. C. Hearps, Amy Brown, George Charalambous, Louise Crossley, et al. "Protocol for a prospective, school-based standardisation study of a digital social skills assessment tool for children: The Paediatric Evaluation of Emotions, Relationships, and Socialisation (PEERS) study." BMJ Open 8, no. 2 (February 2018): e016633. http://dx.doi.org/10.1136/bmjopen-2017-016633.

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BackgroundHumans are by nature a social species, with much of human experience spent in social interaction. Unsurprisingly, social functioning is crucial to well-being and quality of life across the lifespan. While early intervention for social problems appears promising, our ability to identify the specific impairments underlying their social problems (eg, social communication) is restricted by a dearth of accurate, ecologically valid and comprehensive child-direct assessment tools. Current tools are largely limited to parent and teacher ratings scales, which may identify social dysfunction, but not its underlying cause, or adult-based experimental tools, which lack age-appropriate norms. The present study describes the development and standardisation of Paediatric Evaluation of Emotions, Relationships, and Socialisation(PEERS®), an iPad-based social skills assessment tool.MethodsThe PEERS project is a cross-sectional study involving two groups: (1) a normative group, recruited from early childhood, primary and secondary schools across metropolitan and regional Victoria, Australia; and (2) a clinical group, ascertained from outpatient services at The Royal Children’s Hospital Melbourne (RCH). The project aims to establish normative data for PEERS®, a novel and comprehensive app-delivered child-direct measure of social skills for children and youth. The project involves recruiting and assessing 1000 children aged 4.0–17.11 years. Assessments consist of an intellectual screen, PEERS® subtests, and PEERS-Q, a self-report questionnaire of social skills. Parents and teachers also complete questionnaires relating to participants’ social skills. Main analyses will comprise regression-based continuous norming, factor analysis and psychometric analysis of PEERS® and PEERS-Q.Ethics and disseminationEthics approval has been obtained through the RCH Human Research Ethics Committee (34046), the Victorian Government Department of Education and Early Childhood Development (002318), and Catholic Education Melbourne (2166). Findings will be disseminated through international conferences and peer-reviewed journals. Following standardisation of PEERS®, the tool will be made commercially available.
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Connors, Matthew G., Honglei Chen, Haokun Li, Adam Edmonds, Kimberley A. Smith, Colin Gell, Kelly Clitheroe, et al. "Citizen scientists track a charismatic carnivore: Mapping the spread and impact of the South African Mantis (Miomantidae, Miomantis caffra) in Australia." Journal of Orthoptera Research 31, no. 1 (May 19, 2022): 69–82. http://dx.doi.org/10.3897/jor.31.79332.

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The recent integration of citizen science with modern technology has greatly increased its applications and has allowed more people than ever to contribute to research across all areas of science. In particular, citizen science has been instrumental in the detection and monitoring of novel introduced species across the globe. This study provides the first records of Miomantis caffra Saussure, 1871, the South African Mantis, from the Australian mainland and uses records from four different citizen science and social media platforms in conjunction with museum records to track the spread of the species through the country. A total of 153 wild mantises and oothecae were observed across four states and territories (New South Wales, Norfolk Island, Victoria, and Western Australia) between 2009 and 2021. The large number of observations of the species in Victoria and the more recent isolated observations in other states and territories suggest that the species initially arrived in Geelong via oothecae attached to plants or equipment, likely from the invasive population in New Zealand. From there it established and spread outwards to Melbourne and eventually to other states and territories, both naturally and with the aid of human transport. We also provide a comparison of M. caffra to similar native mantises, specifically Pseudomantis albofimbriata (Stål, 1860), and comment on the potential impact and further spread of the species within Australia. Finally, we reiterate the many benefits of engaging directly with citizen scientists in biodiversity research and comment on the decision to include them in all levels of this research investigation.
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Chessman, Bruce C., Nina Bate, Peter A. Gell, and Peter Newall. "A diatom species index for bioassessment of Australian rivers." Marine and Freshwater Research 58, no. 6 (2007): 542. http://dx.doi.org/10.1071/mf06220.

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The Diatom Index for Australian Rivers (DIAR), originally developed at the genus level, was reformulated at the species level with data from diatom sampling of rivers in the Australian Capital Territory, New South Wales, Queensland, South Australia and Victoria. The resulting Diatom Species Index for Australian Rivers (DSIAR) was significantly correlated with the ARCE (Assessment of River Condition, Environment) index developed in the Australian National Land and Water Resources Audit (NLWRA), and with nine of the ARCE’s constituent indices and sub-indices, across 395 river reaches in south-eastern Australia. These correlations were generally stronger than those shown by the biological index that was used to assess river condition in the NLWRA, the ARCB (Assessment of River Condition, Biota) index based on macroinvertebrates and the Australian River Assessment System (AUSRIVAS). At a finer spatial scale, DSIAR was strongly and significantly correlated with measures of catchment urbanisation for streams in the eastern suburbs of Melbourne, Victoria. DSIAR scores across south-eastern Australia bore little relationship to the latitude, longitude or altitude of sampling sites, suggesting that DSIAR is not greatly affected by macro-geographical position. In addition, DSIAR scores did not vary greatly among small-scale hydraulic environments within a site. DSIAR appears to have potential as a broad-scale indicator of human influences on Australian rivers, especially the effects of agricultural and urban land use, and also for impact studies at a local scale. Further evaluation is warranted to test the sensitivity of the index to natural variables such as catchment geology, and to assess its performance in northern, western and inland Australia.
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Walsh, Christopher J. "Biological indicators of stream health using macroinvertebrate assemblage composition: a comparison of sensitivity to an urban gradient." Marine and Freshwater Research 57, no. 1 (2006): 37. http://dx.doi.org/10.1071/mf05041.

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Biological indicators are increasingly being used as integrative measures of ecosystem health in streams, particularly indicators using macroinvertebrate assemblage composition. Several indicators of this type have been advocated, including biotic indices based on taxa sensitivities, richness indices and ratios of observed to expected taxa from models predicting assemblage composition in streams with little human impact (O/E scores). The present study aimed to compare the sensitivity of indicators of each of these types (all used for legislated objectives for stream protection in Victoria, Australia) to a gradient of urban disturbance in 16 streams in a small area in eastern Melbourne. The biotic index SIGNAL and number of Ephemeroptera, Plecoptera or Trichoptera families were the most sensitive indicators, whereas total number of families and O/E scores from Australian river assessment system (AUSRIVAS) models were least sensitive. Differences in sensitivity were not the result of sampling or taxonomic inadequacies. AUSRIVAS and similar models might be improved by using only predictor variables that are not affected by human impacts and by sounder approaches to model selection. Insensitivities of indicators and misclassification of sites by the Victorian objectives show that assessment of indicators against disturbance gradients is critical for setting management objectives based on biological indicators.
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Whelan, Jillian, Joshua Hayward, Melanie Nichols, Andrew D. Brown, Liliana Orellana, Victoria Brown, Denise Becker, et al. "Reflexive Evidence and Systems interventions to Prevention Obesity and Non-communicable Disease (RESPOND): protocol and baseline outcomes for a stepped-wedge cluster-randomised prevention trial." BMJ Open 12, no. 9 (September 2022): e057187. http://dx.doi.org/10.1136/bmjopen-2021-057187.

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IntroductionSystems science methodologies have been used in attempts to address the complex and dynamic causes of childhood obesity with varied results. This paper presents a protocol for the Reflexive Evidence and Systems interventions to Prevention Obesity and Non-communicable Disease (RESPOND) trial. RESPOND represents a significant advance on previous approaches by identifying and operationalising a clear systems methodology and building skills and knowledge in the design and implementation of this approach among community stakeholders.Methods and analysisRESPOND is a 4-year cluster-randomised stepped-wedge trial in 10 local government areas in Victoria, Australia. The intervention comprises four stages: catalyse and set up, monitoring, community engagement and implementation. The trial will be evaluated for individuals, community settings and context, cost-effectiveness, and systems and implementation processes. Individual-level data including weight status, diet and activity behaviours will be collected every 2 years from school children in grades 2, 4 and 6 using an opt-out consent process. Community-level data will include knowledge and engagement, collaboration networks, economic costs and shifts in mental models aligned with systems training. Baseline prevalence data were collected between March and June 2019 among >3700 children from 91 primary schools.Ethics and disseminationEthics approval: Deakin University Human Research Ethics Committee (HREC 2018-381) or Deakin University’s Faculty of Health Ethics Advisory Committee (HEAG-H_2019-1; HEAG-H 37_2019; HEAG-H 173_2018; HEAG-H 12_2019); Victorian Government Department of Education and Training (2019_003943); Catholic Archdiocese of Melbourne (Catholic Education Melbourne, 2019-0872) and Diocese of Sandhurst (24 May 2019). The results of RESPOND, including primary and secondary outcomes, and emerging studies developed throughout the intervention, will be published in the academic literature, presented at national and international conferences, community newsletters, newspapers, infographics and relevant social media.Trial registration numberACTRN12618001986268p.
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Burke, David. "Dementia Care in Victoria: Building a Pathway to Excellence Final Report, Ministerial Taskforce on Dementia Services in Victoria. Melbourne, Australia: Aged, Community & Mental Health Division, Victorian Government Department of Human Services, 1997, 398 pp., No charge." International Psychogeriatrics 11, no. 1 (March 1999): 102–3. http://dx.doi.org/10.1017/s1041610299225628.

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Armstrong, Sarah C., Sarah Lensen, Emily Vaughan, Elaine Wainwright, Michelle Peate, Adam H. Balen, Cynthia M. Farquhar, and Allan Pacey. "VALUE study: a protocol for a qualitative semi-structured interview study of IVF add-ons use by patients, clinicians and embryologists in the UK and Australia." BMJ Open 11, no. 5 (May 2021): e047307. http://dx.doi.org/10.1136/bmjopen-2020-047307.

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IntroductionFor couples undergoing assisted reproduction, a plethora of adjuncts are available; these are known as ‘add-ons’. Most add-ons are not supported by good quality randomised trial evidence of efficacy, with some proven to be ineffective. However, estimates suggest that over 70% of fertility clinics provide at least one add-on, often at extra cost to the patient. This study has three aims. First, to undertake a survey of in vitro fertilisation (IVF) clinics in the UK to ascertain which add-ons are being offered and at what cost. Second, to undertake qualitative semi-structured interviews of patients, clinicians and embryologists, to explore their opinions and beliefs surrounding add-ons. Third, to review the interpretation of the Human Fertilisation and Embryology Authority traffic light system, to better understand the information required by IVF patients, clinicians and embryologists when making decisions about add-ons.Methods and analysisAll UK IVF clinics will be contacted by email and invited to complete an online survey. The survey will ask them which add-ons they offer, at what cost per cycle and how information is shared with patients. Semi-structured interviews will be conducted in the UK and Australia with three groups of participants: (i) fertility patients; (ii) clinicians and (iii) embryologists. Participants for the interviews will be recruited via social media channels, website adverts, email and snowball sampling. Up to 20 participants will be recruited for each group in each country. Following an online consent process, interviews will be conducted via video-conferencing software, transcribed verbatim and data subjected to inductive thematic analysis.Ethics and disseminationEthical approval has been granted by the Universities of Sheffield, Bath Spa and Melbourne. Findings will be published in a peer-reviewed journal and disseminated to regulatory bodies in the UK and Australia. A lay summary of findings will be shared via Fertility Network, UK.
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Abdizadeh, Hadis, Jane Southcott, and Maria Gindidis. "Attitudes of Iranian Community Parents in Australia towards their Children’s Language Maintenance." Heritage Language Journal 17, no. 3 (December 31, 2020): 310–31. http://dx.doi.org/10.46538/hlj.17.3.1.

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Issues of language shift (LS) and language maintenance (LM) are inevitable consequences of globalization and increased mobility of human populations. This qualitative case study investigated attitudes of migrant parents from Iran towards Persian community language maintenance (CLM) for their school-age children in Australia. Ten parents residing in Melbourne, Victoria were interviewed in two groups and demographic data were collected. The participants were seven female and three male parents who had at least one school-age child. In this qualitative case study, data were analyzed thematically. Three major themes concerning Persian CLM were identified: parents’ attitudes, strategies adopted for maintenance, and challenges for their children. The parents believed that CLM supported cultural identity, preserved family cohesion, and fostered bilingualism, all of which were considered valuable future skills for their children. Interviewees adopted diverse strategies including the establishment of family language use policies, sending their children to Iranian community language school, frequent contacts with extended family in Iran, and the use of Persian media and literature. The influential role of siblings and peers in their children’s language shift, and a lack of age-appropriate Persian books and visual materials were the main challenges to CLM mentioned by the parents in this research.
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Kertesz, Margaret, Cathy Humphreys, Lisa Young Larance, Dave Vicary, Anneliese Spiteri-Staines, and Georgia Ovenden. "Working with women who use force: a feasibility study protocol of the Positive (+)SHIFT group work programme in Australia." BMJ Open 9, no. 5 (May 2019): e027496. http://dx.doi.org/10.1136/bmjopen-2018-027496.

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IntroductionThis study assesses the feasibility of the Positive Shift (+SHIFT) programme in the context of legal responses and social welfare provision in the state of Victoria, Australia.The +SHIFT programme, adapted from the Vista curriculum, is a group work and case management programme for women who use force. Building on traditional survivor support group strengths, the programme facilitates participants’ engagement with viable alternatives to force while promoting healing. The study also aims to increase understanding about the characteristics and needs of women who use force in Australia.Methods and analysisThis feasibility study will assess the +SHIFT programme’s appropriateness in addressing women’s use of force in the Victorian context. Process evaluation will be undertaken to identify recruitment, retention, women’s participation, barriers to implementation, the appropriateness of proposed outcome measures and other issues. The feasibility of an outcome evaluation which would employ a longitudinal mixed methods design with measures administered at preprogramme, programme completion and 3 months postprogramme time points, along with semistructured interviews with participants, programme staff and referring professionals, will also be assessed.Ethics and disseminationResearch ethics approval was obtained from the University of Melbourne Human Research Ethics Committee. Results of the study will be communicated to the programme providers as part of the action research process evaluation methodology. On completion, final results will be reported to programme providers and funding bodies, and published in academic journals and presented at national and international conferences.
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Catroppa, Cathy, Nikita Tuli Sood, Elle Morrison, Justin Kenardy, Suncica Lah, Audrey McKinlay, Nicholas Ryan, et al. "The Australian and New Zealand brain injury lifespan cohort protocol: Leveraging common data elements to characterise longitudinal outcome and recovery." BMJ Open 13, no. 1 (January 2023): e067712. http://dx.doi.org/10.1136/bmjopen-2022-067712.

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IntroductionCognitive, behavioural, academic, mental health and social impairments are common following paediatric traumatic brain injury (TBI). However, studies are often reliant on small samples of children drawn from narrow age bands, and employ highly variable methodologies, which make it challenging to generalise existing research findings and understand the lifetime history of TBI.Method and analysisThis study will synthesise common data sets from national (Victoria, New South Wales, Queensland) and international (New Zealand) collaborators, such that common data elements from multiple cohorts recruited from these four sites will be extracted and harmonised. Participant-level harmonised data will then be pooled to create a single integrated data set of participants including common cognitive, social, academic and mental health outcome variables. The large sample size (n=1816), consisting of participants with mild, moderate and severe TBI, will provide statistical power to answer important questions that cannot be addressed by small, individual cohorts. Complex statistical modelling, such as generalised estimation equation, multilevel and latent growth models, will be conducted.Ethics and disseminationEthics approval was granted by the Human Research Ethics Committee (HREC) of the Royal Children’s Hospital (RCH), Melbourne (HREC Reference Number 2019.168). The approved study protocol will be used for all study-related procedures. Findings will be translated into clinical practice, inform policy decisions, guide the appropriate allocation of limited healthcare resources and support the implementation of individualised care.
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Barlow, John W., Timothy C. Crowe, Neil L. Cowen, Lorna E. Raggatt, Duncan J. Topliss, and Jan R. Stockigt. "Stimulation of sex hormone-binding globulin mRNA and attenuation of corticosteroid-binding globulin mRNA by triiodothyronine in human hepatoma cells." European Journal of Endocrinology 130, no. 2 (February 1994): 166–70. http://dx.doi.org/10.1530/eje.0.1300166.

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Barlow JW, Crowe TC, Cowen NL, Raggatt LE, Topliss DJ, Stockigt JR. Stimulation of sex hormone-binding globulin mRNA and attenuation of corticosteroid-binding globulin mRNA by triiodothyronine in human hepatoma cells. Eur J Endocrinol 1994;130:166–70. ISSN 0804–4643 We examined the time course and dose response of the triiodothyronine (T3) effect on mRNAs for sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) in cells of the human hepatoma line HepG2. After 7 h of exposure to a saturating dose of T3, SHBG mRNA was unchanged but increased to 1.5±0.1 times the unstimulated control at 22 h. Maximal stimulation (2.3±0.6) was observed at 2–3 days. Corticosteroid-binding globulin mRNA was unchanged for 22 h after exposure to T3 but diminished thereafter to 64% by day 3. At 3–4 days of exposure, the changes in both SHBG mRNA and CBG mRNA were dose-responsive to the T3 concentration. For both mRNAs, half-maximal response occurred between 10 and 20 pmol/l bioavailable T3. Cortisol-binding proteins secreted by HepG2 cells after 3 days in culture also were T3 dose-responsive. No re-uptake of secreted CBG by the cells was observed, suggesting that the T3 effect on CBG secretion occurs during production of the mature protein. These data suggest that T3 stimulates the expression of the SHBG gene and attenuates the expression of the CBG gene. The effects of T3 on these genes are consistent with the increase in circulating SHBG and decrease in circulating CBG observed in hyperthyroidism. The HepG2 cells may be a useful human cell line in which to study the diversity of the molecular mechanisms of T3 action. JW Barlow, Ewen Downie Metabolic Unit, Alfred Hospital, Commercial Rd. Melbourne, Victoria 3181, Australia
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Chan, Jun Keat, Kah Hong Yep, Sarah Magarey, Zoe Keon-Cohen, and Matt Acheson. "Fit Testing Disposable P2/N95 Respirators during COVID-19 in Victoria, Australia: Fit Check Evaluation, Failure Rates, and a Survey of Healthcare Workers." COVID 1, no. 1 (July 6, 2021): 83–96. http://dx.doi.org/10.3390/covid1010007.

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Quantitative fit testing was utilised to evaluate the Department of Health and Human Services in Victoria (DHHS) recommended fit check and determine pass/fail rates for self-selected P2/N95 respirators. Survey experience and training related to P2/N95 respirators were also obtained. This was an observational study at a specialist tertiary referral centre, Melbourne, Australia, between 29 May 2020 and 5 June 2020. The primary outcome was quantitative fit test pass/fail results, with fit check reported against fit test as a 2 × 2 contingency table. The secondary outcomes were the number of adjustments needed to pass, as well as the pass rates for available sizes and types of self-selected respirators, survey data for attitudes, experience and training for P2/N95 respirators. The fit check predicts respirator seal poorly (PPV 34.1%, 95% CI 25.0–40.5). In total, 69% (40/58) of respirators failed quantitative fit testing after initial respirator application and is a clinically relevant finding (first-up failure rate for P2/N95 respirators). Only one person failed the fit test for all three respirator fit tests. There was significant variability between each of the seven types of self-selected P2/N95 respirators, although sample sizes were small. Few participants were trained in the use of P2/N95 respirators or the fit check prior to COVID-19, with a high number of participants confident in achieving a P2/95 respirator seal following a fit test. The fit check alone was not a validated method in confirming an adequate seal for P2/N95 respirators. Quantitative fit testing can facilitate education, improve the seal of P2/N95 respirators, and needs to be integrated into a comprehensive Respiratory Protection Program (RPP).
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Ruth, Denise, Rosalind Hurworth, and Nabil Sulaiman. "Moving towards meaningful local population health data: The service provider perspective." Australian Journal of Primary Health 11, no. 2 (2005): 113. http://dx.doi.org/10.1071/py05029.

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Increasingly, primary care services are required to use data to assess their local population's health needs and plan services. This paper reports focus group discussions of service providers' perceived current practice, issues and needs related to obtaining and using data for planning services in two local government areas of Melbourne. Six groups were conducted with nominees from two municipal councils, four divisions of general practice, three community health services, three hospital networks and eight community organizations. Two groups were conducted with planners and data providers from the Department of Human Services, Victoria. The 66 participants had a broad range of experience in using data to assess local population health needs. Participants reported that issues limiting the use of data related to: access to data (lack of awareness, contacting the right person, poor communication between data providers and users, resource constraints, lack of central access); gaps in data; quality of data (inconsistent definitions and collection, currency, ties to funding); applicability of data (unfriendly format, problems with aggregated versus small area data, non-matching data sets, lack of contextual information); and support for data use in local population health planning. If local population needs assessment is to lead to better health outcomes, service providers need access to high quality data presented in formats that are applicable to their communities. They also need practicable planning methods, skills training and support in using data for local population needs assessment and service planning.
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Fraser, Heather, Nik Taylor, and Tania Signal. "Young people empathising with other animals: reflections on an Australian RSPCA Humane Education Program." Aotearoa New Zealand Social Work 29, no. 3 (September 25, 2017): 5–16. http://dx.doi.org/10.11157/anzswj-vol29iss3id384.

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INTRODUCTION: Empathy is associated with engagement, compassion, social support and emotional sensitivity, and it is a hallmark of good social work practice. Empathy rightfully receives much attention in social work practice, however, interspecies empathy has yet to be included. This article has been written to address this gap.METHODS: Two main research questions guide our conceptual discussion of young people, interspecies empathy and social work: (1) Why is empathy important to social work with young people? (2) What can an Australian RSPCA Humane Education Programme (HEP) teach social workers about the benefits of interspecies empathy for young people? After our literature review, we examine our illustrative example, which is an HEP offered mostly to newly arrived refugee and migrant young people living in the outer suburbs of Melbourne, whose prior experiences of and/or attitudes towards animals may not have been positive. FINDINGS: Social workers are wise to prioritise empathy because extensive research has shown that, across a diverse range of fields, modes of practice in and beyond social work, empathic practitioners are more effective, achieving better outcomes with their clients. From the letters the young people sent to the RSPCA Victoria after completing an HEP, we note their self-reported increases in empathy for animals, including those they had previously feared or shunned.CONCLUSION: There are many potential benefits of recognising, fostering and valuing interspecies empathy through humane education programmes. However, for these to be ethical, care and empathy must be shown towards the wellbeing of the animals involved, not just the human participants.
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Kiel, Ida Almenning, Sofie Lionett, Evelyn Bridget Parr, Helen Jones, Maria Aurora Hernandez Røset, Øyvind Salvesen, Eszter Vanky, and Trine Moholdt. "Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial." BMJ Open 10, no. 2 (February 2020): e034733. http://dx.doi.org/10.1136/bmjopen-2019-034733.

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IntroductionPolycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age and the leading cause of anovulatory infertility. Women with PCOS have a 15-fold higher prevalence of infertility, compared with women without PCOS, independent of body mass index (BMI). A healthy lifestyle is recommended to improve overall health and fertility in PCOS but there is limited evidence on the isolated effects of exercise, especially for reproductive outcomes. Previous findings indicate superior metabolic health benefits after vigorous compared with moderate-intensity exercise. Our primary aim is to determine the effect of high-intensity interval training (HIT) on menstrual frequency, as a proxy of reproductive function, in women with PCOS.Methods and analysisThe study is a two-centre, randomised, controlled trial with three parallel groups. Women (n=64) from Trondheim (Norway) and Melbourne (Australia) with PCOS according to the Rotterdam criteria will be randomly allocated (1:1:1) to high-volume HIT, low-volume HIT or a control group with no exercise after stratifying for BMI < or ≥ 27 kg/m2and study centre. Measurements for study end points will be undertaken at baseline, after a 16 week exercise intervention and at 12 months following baseline assessments. The primary outcome measure is menstruation frequency, measured as the number of self-reported menstrual bleedings divided by the number of expected menstrual bleedings during a 12-month period. Secondary outcome measurements include markers of cardiovascular, metabolic and reproductive health, as well as quality of life and adherence to and enjoyment of exercise.Ethics and disseminationThe Regional Committee Medical Research Ethics, Norway, and The Australian Catholic University Human Research Ethics Committee, Australia, have approved the trial protocol. This trial will provide new insight regarding the impact of exercise on fertility in PCOS. We expect this trial to contribute to new therapeutic exercise strategies as part of clinical care for women with PCOS.Trial registration numberClinical trial govNCT02419482.
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Zengin, Ayse, Cat Shore-Lorenti, Marc Sim, Louise Maple-Brown, Sharon Lee Brennan-Olsen, Joshua R. Lewis, Jennifer Ockwell, Troy Walker, David Scott, and Peter Ebeling. "Why Aboriginal and Torres Strait Islander Australians fall and fracture: the codesigned Study of Indigenous Muscle and Bone Ageing (SIMBA) protocol." BMJ Open 12, no. 4 (April 2022): e056589. http://dx.doi.org/10.1136/bmjopen-2021-056589.

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ObjectivesAboriginal and Torres Strait Islander Australians have a substantially greater fracture risk, where men are 50% and women are 26% more likely to experience a hip fracture compared with non-Indigenous Australians. Fall-related injuries in this population have also increased by 10%/year compared with 4.3%/year in non-Indigenous Australians. This study aims to determine why falls and fracture risk are higher in Aboriginal and Torres Strait Islander Australians.SettingAll clinical assessments will be performed at one centre in Melbourne, Australia. At baseline, participants will have clinical assessments, including questionnaires, anthropometry, bone structure, body composition and physical performance tests. These assessments will be repeated at follow-up 1 and follow-up 2, with an interval of 12 months between each clinical visit.ParticipantsThis codesigned prospective observational study aims to recruit a total of 298 adults who identify as Aboriginal and Torres Strait Islander and reside within Victoria, Australia. Stratified sampling by age and sex will be used to ensure equitable distribution of men and women across four age-bands (35–44, 45–54, 55–64 and 65+ years).Primary and secondary outcome measuresThe primary outcome is within-individual yearly change in areal bone mineral density at the total hip, femoral neck and lumbar spine assessed by dual energy X-ray absorptiometry. Within-individual change in cortical and trabecular volumetric bone mineral density at the radius and tibia using high-resolution peripheral quantitative computed tomography will be determined. Secondary outcomes include yearly differences in physical performance and body composition.Ethical approvalEthics approval for this study has been granted by the Monash Health Human Research Ethics Committee (project number: RES-19–0000374A).Trial registration numberACTRN12620000161921.
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Gardner, David K., Michelle Lane, Ilan Calderon, and John Leeton. "Environment of the preimplantation human embryo in vivo: metabolite analysis of oviduct and uterine fluids and metabolism of cumulus cells**Supported by IVF America Inc., Greenwich, Connecticut and Monash IVF Pty. Ltd., Melbourne, Victoria, Australia." Fertility and Sterility 65, no. 2 (February 1996): 349–53. http://dx.doi.org/10.1016/s0015-0282(16)58097-2.

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Cheong, Jeanie L. Y., John D. Wark, Michael M. Cheung, Louis Irving, Alice C. Burnett, Katherine J. Lee, Suzanne M. Garland, et al. "Impact of extreme prematurity or extreme low birth weight on young adult health and well-being: the Victorian Infant Collaborative Study (VICS) 1991–1992 Longitudinal Cohort study protocol." BMJ Open 9, no. 5 (May 2019): e030345. http://dx.doi.org/10.1136/bmjopen-2019-030345.

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IntroductionInfants born extremely preterm (EP, <28 weeks’ gestation) or with extremely low birth weight (ELBW,<1000 g) in the era when surfactant has been available clinically are at high risk of health and developmental problems in childhood and adolescence. However, how their health and well-being may be affected in adulthood is not well known. This study aims to compare between EP/ELBW and normal birthweight (NBW) controls: (1) physical health, mental health and socioemotional functioning at 25 years of age and (2) trajectories of these outcomes from childhood to adulthood. In addition, this study aims to identify risk factors in pregnancy, infancy, childhood and adolescence for poor physical health and well-being in EP/ELBW young adults.Methods and analysisThe Victorian Infant Collaborative Study (VICS) is a prospective geographical cohort of all EP/ELBW survivors to 18 years of age born in the State of Victoria, Australia, from 1 January 1991 to 31 December 1992 (n=297) and contemporaneous term-born/NBW controls (n=262). Participants were recruited at birth and followed up at 2, 5, 8 and 18 years. This 25-year follow-up includes assessments of physical health (cardiovascular, respiratory and musculoskeletal), mental health and socioemotional functioning. Outcomes will be compared between the birth groups using linear and logistic regression, fitted using generalised estimating equations (GEEs). Trajectories of health outcomes from early childhood will be compared between the birth groups using linear mixed-effects models. Risk factors for adult outcomes will be assessed using linear and logistic regression (fitted using GEEs).Ethics and disseminationThis study was approved by the Human Research Ethics Committees of the Royal Women’s Hospital, Mercy Hospital for Women, Monash Medical Centre and the Royal Children’s Hospital, Melbourne. Study outcomes will be disseminated through conference presentations, peer-reviewed publications, the internet and social media.
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40

Cullinane, Meabh, Helen L. McLachlan, Michelle S. Newton, Stefanie A. Zugna, and Della A. Forster. "Using the Kirkpatrick Model to evaluate the Maternity and Neonatal Emergencies (MANE) programme: Background and study protocol." BMJ Open 10, no. 1 (January 2020): e032873. http://dx.doi.org/10.1136/bmjopen-2019-032873.

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IntroductionOver 310 000 women gave birth in Australia in 2016, with approximately 80 000 births in the state of Victoria. While most of these births occur in metropolitan Melbourne and other large regional centres, a significant proportion of Victorian women birth in local rural health services. The Victorian state government recently mandated the provision of a maternal and neonatal emergency training programme, called Maternal and Newborn Emergencies (MANE), to rural and regional maternity service providers across the state. MANE aims to educate maternity and newborn care clinicians about recognising and responding to clinical deterioration in an effort to improve clinical outcomes. This paper describes the protocol for an evaluation of the MANE programme.Methods and analysisThis study will evaluate the effectiveness of MANE in relation to: clinician confidence, skills and knowledge; changes in teamwork and collaboration; and consumer experience and satisfaction, and will explore and describe any governance changes within the organisations after MANE implementation. The Kirkpatrick Evaluation Model will provide a framework for the evaluation. The participants of MANE, 27 rural and regional Victorian health services ranging in size from approximately 20 to 1000 births per year, will be invited to participate. Baseline data will be collected from maternity service staff and consumers at each health service before MANE delivery, and at four time-points post-MANE delivery. There will be four components to data collection: a survey of maternity services staff; follow-up interviews with Maternity Managers at health services 4 months after MANE delivery; consumer feedback from all health services collected through the Victorian Healthcare Experience Survey; case studies with five regional or rural health service providers.Ethics and disseminationThis evaluation has been approved by the La Trobe University Science, Health and Engineering College Human Ethics Sub-Committee. Findings will be presented to project stakeholders in a deidentified report, and disseminated through peer-reviewed publications and conference presentations.
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41

Fisher, Jane, Tuan Tran, Stanley Luchters, Thach D. Tran, David B. Hipgrave, Sarah Hanieh, Ha Tran, et al. "Addressing multiple modifiable risks through structured community-based Learning Clubs to improve maternal and infant health and infant development in rural Vietnam: protocol for a parallel group cluster randomised controlled trial." BMJ Open 8, no. 7 (July 2018): e023539. http://dx.doi.org/10.1136/bmjopen-2018-023539.

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IntroductionOptimal early childhood development is an international priority. Risks during pregnancy and early childhood have lasting effects because growth is rapid. We will test whether a complex intervention addressing multiple modifiable risks: maternal nutrition, mental health, parenting capabilities, infant health and development and gender-based violence, is effective in reducing deficient cognitive development among children aged two in rural Vietnam.Methods and analysisThe Learning Clubs intervention is a structured programme combining perinatal stage-specific information, learning activities and social support. It comprises 20 modules, in 19 accessible, facilitated groups for women at a community centre and one home visit. Evidence-informed content is from interventions to address each risk tested in randomised controlled trials in other resource-constrained settings. Content has been translated and culturally adapted for Vietnam and acceptability and feasibility established in pilot testing.We will conduct a two-arm parallel-group cluster-randomised controlled trial, with the commune as clustering unit. An independent statistician will select 84/112 communes in Ha Nam Province and randomly assign 42 to the control arm providing usual care and 42 to the intervention arm. In total, 1008 pregnant women (12 per commune) from 84 clusters are needed to detect a difference in the primary outcome (Bayley Scales of Infant and Toddler Development Cognitive Score <1 SD below standardised norm for 2 years of age) of 15% in the control and 8% in the intervention arms, with 80% power, significance 0.05 and intracluster correlation coefficient 0.03.Ethics and disseminationMonash University Human Research Ethics Committee (Certificate Number 20160683), Melbourne, Victoria, Australia and the Institutional Review Board of the Hanoi School of Public Health (Certificate Number 017-377IDD- YTCC), Hanoi, Vietnam have approved the trial. Results will be disseminated through a comprehensive multistranded dissemination strategy including peer-reviewed publications, national and international conference presentations, seminars and technical and lay language reports.Trial registration numberACTRN12617000442303; Pre-results.
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Cuthbert, Denise, and Marian Quartly. "Adoption, fostering, permanent care and beyond Re-thinking policy and practice on out-of-home care for children in Australia." Children Australia 35, no. 2 (2010): 2–5. http://dx.doi.org/10.1017/s1035077200000985.

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The papers published in this special issue of Children Australia were originally presented at a two day symposium held in Melbourne on 26 and 27 November 2009. The symposium, Adoption, fostering, permanent care and beyond: Re-thinking policy and practice on out-of-home care for children in Australia, was jointly convened by the Department of Human Services (DHS), Victoria and the School of Political and Social Inquiry at Monash University in conjunction with the History of Adoption in Australia project (Monash University 2009).The event was a partnership between professionals working in this area and university researchers. Each group brought different perspectives and imperatives to the table. For DHS and the sector, the immediate frame of the symposium was the major policy statement Directions for out-of-home care, announced in May 2009 by the Victorian Minister for Community Services after consultation with community service organisations and young people living in care (DHS 2009a). It announces a framework for change which incorporates action on seven fronts or ‘reform directions’. These are to support children to remain at home with their families; to provide a better choice of care placement; to promote wellbeing; to prepare young people who are leaving care to make the transition into adult life; to improve the education of children in care; to develop effective and culturally appropriate responses to the high numbers of Aboriginal children in our care; and to create a child-focused system and processes (DHS 2009a). The driving principle informing the reforms is to ensure that policy and service provision are centred on the needs and interests of children and young people, and to ensure that young people are consulted as to what their needs are (rather than assumptions being made by adults as to their needs).
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43

Goller, Jane L., Jacqueline Coombe, Meredith Temple-Smith, Helen Bittleston, Lena Sanci, Rebecca Guy, Christopher Fairley, et al. "Management of Chlamydia Cases in Australia (MoCCA): protocol for a non-randomised implementation and feasibility trial." BMJ Open 12, no. 12 (December 2022): e067488. http://dx.doi.org/10.1136/bmjopen-2022-067488.

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IntroductionThe sexually transmitted infection chlamydia can cause significant complications, particularly among people with female reproductive organs. Optimal management includes timely and appropriate treatment, notifying and treating sexual partners, timely retesting for reinfection and detecting complications including pelvic inflammatory disease (PID). In Australia, mainstream primary care (general practice) is where most chlamydia infections are diagnosed, making it a key setting for optimising chlamydia management. High reinfection and low retesting rates suggest partner notification and retesting are not uniformly provided. The Management of Chlamydia Cases in Australia (MoCCA) study seeks to address gaps in chlamydia management in Australian general practice through implementing interventions shown to improve chlamydia management in specialist services. MoCCA will focus on improving retesting, partner management (including patient-delivered partner therapy) and PID diagnosis.Methods and analysisMoCCA is a non-randomised implementation and feasibility trial aiming to determine how best to implement interventions to support general practice in delivering best practice chlamydia management. Our method is guided by the Consolidated Framework for Implementation Research and the Normalisation Process Theory. MoCCA interventions include a website, flow charts, fact sheets, mailed specimen kits and autofills to streamline chlamydia consultation documentation. We aim to recruit 20 general practices across three Australian states (Victoria, New South Wales, Queensland) through which we will implement the interventions over 12–18 months. Mixed methods involving qualitative and quantitative data collection and analyses (observation, interviews, surveys) from staff and patients will be undertaken to explore our intervention implementation, acceptability and uptake. Deidentified general practice and laboratory data will be used to measure pre-post chlamydia testing, retesting, reinfection and PID rates, and to estimate MoCCA intervention costs. Our findings will guide scale-up plans for Australian general practice.Ethics and disseminationEthics approval was obtained from The University of Melbourne Human Research Ethics Committee (Ethics ID: 22665). Findings will be disseminated via conference presentations, peer-reviewed publications and study reports.
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44

Fisher, M., F. McRae, M. Pitcher, I. Hornung, and J. Spence. "Bridge of Support: A Collaborative Approach to a Peer Support Program." Journal of Global Oncology 4, Supplement 2 (October 1, 2018): 169s. http://dx.doi.org/10.1200/jgo.18.74600.

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Background and context: The Bridge of Support Program (BOS) is adapting a successful community based model of peer support to an acute setting, at the Sunshine Hospital Breast Clinic, to meet the cultural and socioeconomic diverse needs of women with breast cancer. This two year project was funded by LUCRF Community Partnership Trust. Aim: To improve the experience of women undergoing treatment of breast cancer at Western Health. To improve access to psych-social, emotional and practical support for women by extending the reach of CounterPart- a state-wide service of women´s Health Victoria, funded by the Victorian Department of Health and Human Services to provide peer support and information to people affected by breast or a gynecologic cancer. Program/Policy process: Peer support volunteers actively guided women to current and credible evidence-based information, support decision making and provide emotional support. Peer support volunteers are rostered once a week at Sunshine Hospital to coincide with breast clinic and include access to the day oncology unit and radiotherapy center. Detailed contact information is recorded and women receive follow-up contact (with consent) from the peer support volunteers at the CounterPart Resource Centre in Melbourne. A CounterPart staff member oversees the project and provides direct support and supervision to the volunteers on site at the hospital. Women can self refer. Outcomes: Between February and December 2016 the BOS program had 159 separate contacts with patients and their families. 82 contacts were with men and women who were new to CounterPart and 77 were follow-up contacts. 90 individuals treated for breast cancer at Western Health accessed the program, which represent 53% of the women seen by the breast service. 48% of the contacts were follow-up contacts with the CounterPart volunteers indicating that once engaged with the service many men and women continue to make contact. 38% of contacts were with women diagnosed with metastatic disease, a group who often have higher levels of unmet or more complex needs. 49% were born in a nonmain English speaking country (compared with the overall state of Victoria average of 19.6%) thus reflecting an accessible service to the non-English speaking community. What was learned: At a time when peer support is being increasingly recognized as a key part of effective supportive care in cancer services, the BOS program offers a model of integrated peer support that is respected, reliable, well supported and safe within the acute setting. This acute-community sector partnership demonstrates how the medical and social models of health care can work together to provide a connected and quality service for men and women diagnosed with breast cancer. An active research approach is enabling the project to be responsive to issues and challenges as they arise including the ongoing recruitment of women as volunteers from the local community to work within the acute setting.
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Hyne, Ross V., Alexander Stojanoff, Gary N. Clarke, Alexander Lopata, and W. Ian H. Johnston. "Pregnancy from in vitro fertilization of human eggs after separation of motile spermatozoa by density gradient centrifugation**Supported in part by National Health and Medical Research Council grants to R. V. H. and A. L. and by Pharmacia (South Seas) Pty. Ltd., Melbourne, Victoria, Australia." Fertility and Sterility 45, no. 1 (January 1986): 93–96. http://dx.doi.org/10.1016/s0015-0282(16)49103-x.

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46

Confino, Edmond, Richard H. Demir, Jan Friberg та Norbert Gleicher. "The predictive value of hCG β subunit levels in pregnancies achieved by in vitro fertilization and embryo transfer: an international collaborative study**Supported by the Foundation for Reproductive Medicine, Inc., Chicago, Illinois.††The International Investigators in collaboration for this study were Benjamin G. Brackett, M.D., Ph.D., The University of Georgia College of Veterinary Medicine, Atlanta, Georgia; Jairo Garcia, M.D., Suheil Muasher, M.D., Anibal A. Acosta, M.D., Mason C. Andrews, M.D., Gary Hodgen, Ph.D., Zev Rosenwaks, M.D., Georgeanna Seegar Jones, M.D., and Howard W. Jones, Jr., M.D., Eastern Virginia Medical School, Norfolk, Virginia; Robert H. Glass, M.D., Mary C. Martin, M.D., and Pramila Dandekar, M.Sc., University of California, San Francisco, California; Vesselko Grizelj, M.D., Ph.D., University Medical School of Zagreb, Zagreb, Yugoslavia; George Henry, M.D., Jon Van Blerkom, M.D., and Barbara J. Corn, R.N., Reproductive Genetics, In Vitro, P.C., Denver, Colorado; Aarne Koskimies, M.D., and Markku Seppälä, M.D., Helsinki University Central Hospital, Helsinki, Finland; David Magyar, M.D., Robert J. Sokol, M.D., and Patricia A. Rogus, R.N., Hutzel Hospital, Wayne State University, Detroit, Michigan; H. W. Michelmann, M.D., and L. Mettler, M.D., Universitats Frauenklinik, Kiel, German Federal Republic; Jean Parinaud, Ph.D., and Georges Pontonnier, M.D., Institut National de la Santé et de la Recherche Médicale, Toulouse, France; E. van Roosendaal, M.D., and R. Schoysman, M.D., Academisch Ziekenhuis Vrije Universiteit, Brussels, Belgium; Melvin Taymor, M.D., Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts; Raimund Winter, M.D., Geburtshilflich-Gynakologische Universitatsklinik Graz, Graz, Austria; Richard J. Worley, M.D., and William R. Keye, Jr., M.D., University of Utah Medical Center, Salt Lake City, Utah; and John L. Yovich, F.R.A.C.O.G., University of Western Australia, Subiaco, Perth, Western Australia, Australia.‡‡Presented at The American College of Obstetricians and Gynecologists District VI Annual Meeting, September 25 to 28, 1985, Milwaukee, Wisconsin; the 41st Annual Meeting of The American Fertility Society, September 28 to October 2, 1985, Chicago, Illinois; and the 4th World Conference on In Vitro Fertilization, November 18 to 22, 1985, Melbourne, Victoria, Australia." Fertility and Sterility 45, № 4 (квітень 1986): 526–31. http://dx.doi.org/10.1016/s0015-0282(16)49282-4.

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47

Boyle, Malcolm, Stephen Burgess, Mark Chilton, Brian Fallows, Bill Lord, David Shugg, Brett Williams, and Andrea Wyatt. "Monash University Centre for Ambulance and Paramedic Studies (MUCAPS) Submission to the Department of Human Services (DHS), in response to the DHS Discussion Paper examining the regulation of the Health Professions in Victoria." Australasian Journal of Paramedicine 1, no. 3 (October 6, 2003). http://dx.doi.org/10.33151/ajp.1.3.208.

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This submission will primarily address the regulation of the health professions from the perspective of an education institution, and is made in response to the Discussion paper examining regulation of the health professions in Victoria, dated October 2003 which was issued by the Policy and Strategic Projects Division of the Victorian Department of Human Services, Melbourne, Victoria.
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Williams, Brett. "Removal of Invasive Devices from Deceased Persons: Forensic implications for Paramedics – a Victorian perspective." Australasian Journal of Paramedicine 3, no. 4 (July 14, 2015). http://dx.doi.org/10.33151/ajp.3.4.339.

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Professor Cordner is Professor of forensic medicine at Monash University Institutes of Health and Director of the Victorian Institute of Forensic Medicine His work in the area of forensic medicine and human rights has seen him take tours of duty in East Timor and Kosovo, as well as a year-long stint consulting to the International Committee of the Red Cross in Geneva. The following interview was conducted to invite Professor Cordner’s professional opinion in relation to practices and implications with respect to the removal of invasive clinical devices from deceased persons, as they currently apply to paramedics of Metropolitan Ambulance Service in Melbourne, and Rural Ambulance Victoria.
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49

Price, Olivia H., Natalie Spirason, Cleve Rynehart, Sook Kwan Brown, Angela Todd, Heidi Peck, Manisha Patel, Sally Soppe, Ian G. Barr, and Michelle K. Chow. "Report on influenza viruses received and tested by the Melbourne WHO Collaborating Centre for Reference and Research on Influenza in 2018." Communicable Diseases Intelligence 44 (March 16, 2020). http://dx.doi.org/10.33321/cdi.2020.44.16.

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As part of its role in the World Health Organization’s (WHO) Global Influenza Surveillance and Response System (GISRS), the WHO Collaborating Centre for Reference and Research on Influenza in Melbourne received a total of 3993 human influenza-positive samples during 2018. Viruses were analysed for their antigenic, genetic and antiviral susceptibility properties. Selected viruses were propagated in qualified cells or hens’ eggs for use as potential seasonal influenza vaccine virus candidates. In 2018, influenza A(H1)pdm09 viruses predominated over influenza A(H3) and B viruses, accounting for a total of 53% of all viruses analysed. The majority of A(H1)pdm09, A(H3) and influenza B viruses analysed at the Centre were found to be antigenically similar to the respective WHO-recommended vaccine strains for the Southern Hemisphere in 2018. However, phylogenetic analysis indicated that a significant proportion of circulating A(H3) viruses had undergone genetic drift relative to the WHO-recommended vaccine strain for 2018. Of 2864 samples tested for susceptibility to the neuraminidase inhibitors oseltamivir and zanamivir, three A(H1)pdm09 viruses showed highly reduced inhibition by oseltamivir, while one B/Victoria virus showed highly reduced inhibition by both oseltamivir and zanamivir.
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Leung, Vivian k., Yi-Mo Deng, Matthew Kaye, Iwona Buettner, Hilda Lau, Sook-Kwan Leang, Leah Gillespie, and Michelle K. Chow. "Annual report on influenza viruses received and tested by the Melbourne WHO Collaborating Centre for Reference and Research on Influenza in 2016." Communicable Diseases Intelligence 43 (February 1, 2019). http://dx.doi.org/10.33321/cdi.2019.43.3.

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As part of its role in the World Health Organization’s (WHO) Global Influenza Surveillance and Response System (GISRS), the WHO Collaborating Centre for Reference and Research on Influenza in Melbourne received a total of 4,247 human influenza positive samples during 2016. Viruses were analysed for their antigenic, genetic and antiviral susceptibility properties and also propagated in qualified cells and hens eggs for potential seasonal influenza vaccine virus candidates. In 2016, influenza A(H3) viruses predominated over influenza A(H1)pdm09 and B viruses, accounting for a total of 51% of all viruses analysed. The vast majority of A(H1)pdm09, A(H3) and influenza B viruses analysed at the Centre were found to be antigenically similar to the respective WHO recommended vaccine strains for the Southern Hemisphere in 2016. However, phylogenetic analysis of a selection of viruses indicated that the majority of circulating A(H3) viruses had undergone some genetic drift relative to the WHO recommended strain for 2016. Of more than 3,000 samples tested for resistance to the neuraminidase inhibitors oseltamivir and zanamivir, six A(H1)pdm09 viruses and two B/Victoria lineage viruses showed highly reduced inhibition to oseltamivir.
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