Статті в журналах: "FEMA DOCUMENT"

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Lukkunaprasit, Panitan, Nuttawut Thanasisathit, and Harry Yeh. "Experimental Verification of FEMA P646 Tsunami Loading." Journal of Disaster Research 4, no. 6 (December 1, 2009): 410–18. http://dx.doi.org/10.20965/jdr.2009.p0410.

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The 2004 catastrophe of the Indian Ocean tsunami prompted scientists and engineers to develop better guidelines for economically designed essential buildings that are capable of withstanding tsunami forces. A recent design guidelines document – FEMA P646 [1] published by the US Federal Emergency Management Agency (FEMA) – proposes a practical method to estimate the tsunami design forces at a given locality with a known maximum tsunami runup height. This paper focuses on verifying the method stipulated in FEMA P646 through laboratory experiments, assuming the beach condition similar to Kamala beach in Phuket, Thailand, which suffered great losses by the 2004 Indian Ocean tsunami. Our experimental results confirm that the predicted forces provide a reasonable upper bound for the measured forces.

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Malley, James O., Charles J. Carter, and C. Mark Saunders. "Seismic Design Guidelines and Provisions for Steel-Framed Buildings: FEMA 267/267A and 1997 AISC Seismic Provisions." Earthquake Spectra 16, no. 1 (February 2000): 179–203. http://dx.doi.org/10.1193/1.1586090.

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One of the important surprises of the Northridge earthquake of January 17, 1994, was the widespread and unanticipated brittle fracture of welded steel beam-to-column connections. Although no casualties or collapses occurred during the Northridge earthquake as a result of these connection failures, and many WSMF buildings were not damaged at all, a wide spectrum of brittle connection damage did occur, ranging from minor cracking to completely severed columns. This paper summarizes two of the most important documents that have been developed in response to the damage suffered to steel moment frame buildings in the Northridge earthquake. The first, FEMA 267, Interim Guidelines: Evaluation, Repair, Modification and Design of Welded Steel Moment Frame Structures, was generated from studies undertaken as part of a project initiated by the U.S. Federal Emergency Management Agency (FEMA) to reduce the earthquake hazards posed by steel moment-resisting frame buildings. The second document addressed in this paper is the 1997 edition of the American Institute of Steel Construction (AISC) Seismic Provisions for Structural Steel Buildings (commonly referred to as the AISC Seismic Provisions) that incorporates the new information generated by the FEMA-sponsored project and other investigations on the seismic performance of steel structures, and has been adopted by reference into the 2000 International Building Code (IBC).

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Han, Sharon. "Weathering the Twitter Storm." Information Technology and Libraries 38, no. 2 (June 17, 2019): 37–48. http://dx.doi.org/10.6017/ital.v38i2.11018.

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After a disaster, news reports and online platforms often document the swift response of public libraries supporting their communities. Despite current scholarship focused on social media in disasters, early uses of social media as an extension of library services require further scrutiny. The Federal Emergency Management Agency (FEMA) recognized Hurricane Sandy as one of the earliest U.S. disasters in which first responders used social media. This study specifically examines early uses of Twitter by selected public libraries as an information tool during Sandy’s aftermath. Results can inform uses of social media in library response to future disasters.

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Ismail, Refaat Taleb, K. Rama Mohana Rao, and Srikanth Devi. "Estimation of Lateral Load Distribution Pattens in Nonlinear Static Procedures for RCC Framed Buildings." International Journal for Research in Applied Science and Engineering Technology 11, no. 1 (January 31, 2023): 356–63. http://dx.doi.org/10.22214/ijraset.2023.48575.

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Abstract: In the context of the seismic evaluation of building structures, nonlinear static analysis that makes use of pushover processes is becoming an increasingly common technique in engineering practice. In order to carry out a pushover study, the document FEMA-356 (2000) suggests using a variety of distributions of lateral forces. The use of these force distributions, on the other hand, does not adequately reflect the effects of modifying dynamic parameters across the inelastic response or the influence of higher modes. Four different lateral load patterns are investigated in this body of work by contrasting the pushover responses of RCC moment frame buildings with five and twelve stories.

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Sobelson, PhD, Robyn K., Corinne J. Wigington, MPH, and Victoria Harp, BA. "A whole community approach to emergency management: Strategies and best practices of seven community programs." Journal of Emergency Management 13, no. 4 (July 1, 2015): 349. http://dx.doi.org/10.5055/jem.2015.0247.

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Objective: In 2011, the Federal Emergency Management Agency (FEMA) published the Whole Community Approach to Emergency Management: Principles, Themes, and Pathways for Action, outlining the need for increased individual preparedness and more widespread community engagement to enhance the overall resiliency and security of communities. However, there is limited evidence of how to build a whole community approach to emergency management that provides real-world, practical examples and applications. This article reports on the strategies and best practices gleaned from seven community programs fostering a whole community approach to emergency management.Design: The project team engaged in informal conversations with community stakeholders to learn about their programs during routine monitoring activities, site visits, and during an in-person, facilitated workshop. A total of 88 community members associated with the programs examples contributed. Qualitative analysis was conducted.Results: The findings highlighted best practices gleaned from the seven programs that other communities can leverage to build and maintain their own whole community programs. The findings from the programs also support and validate the three principles and six strategic themes outlined by FEMA. Conclusions: The findings, like the whole community document, highlight the importance of understanding the community, building relationships, empowering action, and fostering social capital to build a whole community approach.

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6

Mayes, Ronald, Nicholas Wetzel, Ben Weaver, Ken Tam, Will Parker, Andrew Brown, and Dario Pietra. "Performance based design of buildings to assess damage and downtime and implement a rating system." Bulletin of the New Zealand Society for Earthquake Engineering 46, no. 1 (March 31, 2013): 40–55. http://dx.doi.org/10.5459/bnzsee.46.1.40-55.

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The Christchurch earthquakes have highlighted the mismatch in expectations between the engineering profession and society regarding the seismic performance of buildings. While most modern buildings performed as expected, many buildings have been, or are to be, demolished. The ownership, occupancy, and societal costs of only targeting life-safety as the accepted performance standard for building design are now apparent in New Zealand. While the structural system has a significant effect on the seismic performance of the entire building, including the contents, it is only about 20% of the total building cost. Hence, structural engineers should view the seismic performance in a wider context, looking at all the systems of the building rather than just the damage to structural items and life-safety. The next generation of performance-based seismic design procedures, outlined in the FEMA P-58 document, provide engineers with the tools to express the seismic performance of the entire building in terms of the future life loss, facility repair cost and repair time. This paper will outline the FEMA P-58 procedure and present the results of a comparative study of six different structural systems for a three storey commercial and laboratory building: moment frame; buckling restrained braced frame; viscously damped moment frame; Pres-Lam timber coupled-walls; cast-in-place reinforced concrete shear wall; and base isolated braced frame. Each system was analysed as a fully non-linear structure and the calculated drifts and floor accelerations were input into the FEMA P-58 PACT tool to evaluate the overall building performance. The PACT tool performs loss calculations for the expected casualties, repair cost, and repair time from which a QuakeStar or SEAONC rating for the building can be obtained.

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Celenza, James. "Protecting Disaster Site, Support, and Recovery Workers." NEW SOLUTIONS: A Journal of Environmental and Occupational Health Policy 18, no. 3 (September 30, 2008): 329–32. http://dx.doi.org/10.2190/ns.18.3.f.

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When a disaster strikes, FEMA activates the worker safety and health provisions (annex document) of the National Response Plan (NRP). The annex describes actions needed to ensure that threats to safety and health are recognized, evaluated, and controlled consistently so that responders are properly protected during incident management operations. The activation of the Worker Safety and Health Annex gives the Occupational Safety and Health Administration (OSHA) the responsibility to coordinate a comprehensive response involving federal, state, and local agencies and private-sector organizations to ensure the safety and health needs of responders are met. There is confusion, however, as to whether OSHA is acting as an advisory “coordinator” or as an enforcement agency. OSHA personnel at the WTC and the Gulf region reported they were not clear what role they must perform (and the language in the National Response Plan is not explicit). Thus, the need for a clear and comprehensive mandatory program.

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8

Robertson, Ian, Gary Chock, and Juan Morla. "Structural Analysis of Selected Failures Caused by the 27 February 2010 Chile Tsunami." Earthquake Spectra 28, no. 1_suppl1 (June 2012): 215–43. http://dx.doi.org/10.1193/1.4000035.

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Following the 2010 Chile earthquake and tsunami, the authors participated in the EERI reconnaissance team that traveled to Chile to document damage and structural performance. The authors focused on tsunami damage following the earthquake. A summary of tsunami damage to structures is given. Based on a series of well-defined structural element failures at sites where inundation depth was measured, the team was able to evaluate the hydrodynamic loading required to cause these failures and derive estimated lower bound flow velocity overland during the event. It was estimated that the velocity exceeded 3.2 m/s in Talcahuano harbor and 4.3 m/s in the coastal town of Dichato. When found in proximity to damaged buildings and other larger structures of interest, these simple structures can serve as “flow surrogate instruments” to estimate the local flow velocity. Failure analysis of these simple structures indicated that the hydrodynamic loading estimates provided by FEMA P646 may be unconservative.

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9

Zsarnóczay, Ádám, Tamás Balogh, and László Gergely Vigh. "On the European Norms of Design of Buckling Restrained Braced Frames." Open Civil Engineering Journal 11, no. 1 (June 30, 2017): 513–30. http://dx.doi.org/10.2174/1874149501711010513.

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The application of buckling restrained braced frames is hindered in Europe by the absence of a standardized design procedure in Eurocode 8, the European seismic design standard. The presented research aims to develop a robust design procedure for buckling restrained braced frames. A design procedure is proposed by the authors. Its performance has been evaluated for buckling restrained braced frames with two-bay X-brace type brace configurations using a state-of-the-art methodology based on the recommendations in the FEMA P695 document. A special numerical material model was developed within the scope of this research to represent the behavior of buckling restrained braces more appropriately in a numerical environment. A total of 24 archetype designs were prepared and their nonlinear dynamic response was calculated using real ground motion records in incremental dynamic analyses. Evaluation of archetype collapse probabilities confirms that the proposed design procedure can utilize the advantageous behavior of buckling restrained braces. Resulting reliability indices suggest a need for additional regulations in the Eurocodes that introduce reasonable structural reliability index limits for seismic design.

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10

Ergunes, Orhan Ilkay, and Tulay Aksu Ozkul. "Seismic Assessment of Tall Buildings Designed According to the Turkish Building Earthquake Code." Civil Engineering Journal 8, no. 3 (March 1, 2022): 567–79. http://dx.doi.org/10.28991/cej-2022-08-03-011.

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For the first time, the 2018 edition of the Turkish Building Earthquake Code has added a dedicated chapter for the design of high-rise buildings in earthquake-prone areas. Keeping in view the widely practised design option of rigid shear walls at the centre of a high-rise structure, the latest code has additionally defined limits for shear-wall axial forces in high-rise buildings. The new shear-wall axial force limits have not been independently investigated for optimal design and criticality. This calls for a detailed investigation of the newly defined axial force limits for the design of high-rise buildings in Turkey, where seismic activity has historically remained high. This study, therefore, investigates the effect of variation in limit values of shear wall axial forces on the collapse prevention of such buildings. A high-rise building designed entirely according to the code was chosen as the base model. The location of the building is in Istanbul, which has the highest number of tall buildings as compared to other cities in Turkey. A total of 7 alternative models were created by changing the concrete material class and the thickness of shear walls. This approach allowed us to quantify the effect of shear-wall thickness and its criticality against another important design consideration, i.e., the compressive strength of concrete. Forty different earthquake ground motion records were used to analyse the models to determine how critical the axial force ratio of the shear walls is in terms of collapse probability. The method proposed in the Federal Emergency Management Agency (FEMA) document FEMA P695 was followed to determine the collapse levels for the high-rise structures. A nonlinear analysis was performed to analyse the failure safety of the models. Results indicate that an increase or decrease in the axial force ratios by more than 15% renders the structure either overdesigned or deficient. Doi: 10.28991/CEJ-2022-08-03-011 Full Text: PDF

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11

Filiatrault, Andre, Peter S. Higgins, Assawin Wanitkorkul, James A. Courtwright, and Robert Michael. "Experimental Seismic Response of Base Isolated Pallet-Type Steel Storage Racks." Earthquake Spectra 24, no. 3 (August 2008): 617–39. http://dx.doi.org/10.1193/1.2942375.

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This paper presents the results of uniaxial and triaxial shake table tests performed on directly anchored and base isolated steel pallet storage racks loaded with simulated and real merchandise. The new base isolation system provides seismic isolation in the cross-aisle direction of a rack only, while providing similar restraints as conventional bolted base plates in the down-aisle direction. The objective of the isolation in the cross-aisle direction is to reduce the horizontal accelerations of the rack in order to reduce content spillage and structural damage during a major seismic event, without interfering with normal material handling operations. Base isolation is not provided in the down-aisle direction since the range of down-aisle natural periods of typical rack structures is already similar to that of typical base isolated structures. The results of the seismic tests clearly demonstrated the improved structural performance of rack structures incorporating the new cross-aisle base isolation system. Cross-aisle absolute accelerations and interstory drifts of the base isolated rack structure were reduced considerably compared to the values measured in the same rack conventionally anchored at its base. The base isolation system also had an effect in reducing the down-aisle accelerations. The base isolated racks met the performance objectives recommended in the FEMA 460 document “Seismic Considerations for Steel Storage Racks Located in Areas Accessible to the Public” both for life safety under the Design Earthquake (DE) and for collapse prevention under the Maximum Considered Earthquake (MCE).

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Aroca Córdova, Álvaro. "Diseño de herramientas de análisis artístico-medioambiental: Reserva de la Biosfera de Urdaibai como caso de estudio." AUSART 4, no. 1 (July 12, 2016): 77–89. http://dx.doi.org/10.1387/ausart.16682.

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A partir de la experiencia artística ambiental de la reserva de Urdaibai, la investigación establece indicadores artísticos-medioambientales, técnicos-medioambientales, de impacto ambiental y de sostenibilidad, que permiten determinar y evaluar elementos artísticos- medioambientales de una intervención en las que se da una interacción entre los elementos constituyentes de la obra y un medio natural. Como resultado, se obtuvo un documento de índole sensitivo-artístico-medio ambiental, herramienta de evaluación llamada FEAM “Ficha de Evaluación Artístico Ambiental”. En dicha reserva, se desarrollo el proyecto “Sentido y Sostenibilidad”, consistente en la intervención de obras “sitio-especificas” de diez artistas”. La investigación entregó directrices que sirvieron para mejorar y optimizar la FEAM (Ficha de Evaluación Artístico Ambiental).Palabras-clave: EVALUACIÓN; SOSTENIBILIDAD; ARTE; MEDIO AMBIENTE; URDAIBAI Artistic-environmental analysis tools design: Urdaibai Biosphere Reserve as a case studyAbstractBased on the environmental-artistic experience from the Urdaibai´s reserve, our research establishes environmental-artistic indicators, environmental-technical indicators and the sustainability and the environmental impact that allow to determinate and evaluate the environmental-artistic elements of the intervention, in which an interaction between the elements of the artwork and the environment takes place. As a result, a document of such sensitive- artistic meaning came out, as a tool of assessment called FEAM “environmental- artistic evaluation form”. In this nature reserve, it was developed the project “Sense and Sustainability”, which consists of ten site-specific artworks from different artists. The research produced indicators that were useful in order to improve and optimize the FEAM (Environmental-Artistic Evaluation Form).Keywords: ASSESSMENT; SUSTAINABILITY; ART; ENVIRONMENT; URDAIBAI

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13

Connolly, EdD, Maureen. "Aligning Institutions of Higher Education emergency preparedness plans with the National Response Framework." Journal of Emergency Management 10, no. 4 (July 1, 2012): 241. http://dx.doi.org/10.5055/jem.2012.0102.

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Colleges and universities must be prepared to respond to events that could compromise the safety of any person in a classroom, residence hall, office, or any other campus facility as well as for any event that could jeopardize the continuation of use of any campus facility. The Federal Emergency Management Agency (FEMA) states, “Higher education institutions ... are realizing that improving their campus’ resistance to disaster will not only protect their own lives and those of their students, it will also safeguard their campus’ instruction, research, and public service.” The US Department of Homeland Security, FEMA developed the overarching strategy, the National Response Framework (NRF), for emergency preparedness for “government executives, private-sector and nongovernmental organization leaders.” FEMA and the Department of Education (DOE) developed specific guidelines for emergency preparedness for colleges and universities. This study linked these guidelines to the five principles of the NRF. Most institutions have an emergency preparedness plan, but just how effective are these plans? Do community colleges, state, independent, and proprietary institutions differ in terms of their level of emergency preparedness? The target population for this study is colleges and universities in the United States. This quantitative study measured how aligned the emergency preparedness plans of these colleges and universities are to the recommendations of FEMA and the US DOE, Office of Safe and Drug-Free Schools. The data suggest that much more needs to be done to bring college and university emergency plans into alignment with the government recommendations. Alignment with the government documents for this sample of US colleges and universities is extremely low for each principle of the NRF.

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Whittaker, Andrew, Michael Constantinou, and Natali Sigaher. "SUPPLEMENTAL DAMPING FOR NEW AND RETROFIT CONSTRUCTION*." Revista de Ingeniería Sísmica, no. 61 (July 1, 1999): 1. http://dx.doi.org/10.18867/ris.61.236.

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Supplemental damping (energy dissipation) hardware are being employed in the United States to provide enhanced protection for new and retrofit building and bridge construction. Such hardware includes displacement- and velocity-dependent dampers. The types of dampers being implemented in the United States at this time are presented in the paper. Guidelines and commentary to aid in the implementation of passive supplemental dampers in existing construction are included in the new resource documents FEMA 273 and 274: Guidelines for the Seismic Rehabilitation of Buildings (FEMAThi, 1997). This paper introduces the FEMA 273 analysis procedures and outlines the modeling and analysis procedures developed for implementing supplemental dampers. Two new developments in the field of supplemental damping that will facilitate their application to stiff structural framing systems are the toogle-brace and scissors-jack damper configurations. These configurations are presented in the paper and their utility is demonstrated by comparison with conventional configurations for a sample single-story, single-bay frame.

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15

Lin, Yu-Yuan, Meng-Hao Tsai, and Kuo-Chun Chang. "On the Discussion of the Damping Reduction Factors in the Constant Acceleration Region for ATC-40 and FEMA-273." Earthquake Spectra 19, no. 4 (November 2003): 1001–6. http://dx.doi.org/10.1193/1.1623784.

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According to the ATC-40 (1996) and FEMA-273 (1997) documents, the damping reduction factors for the constant acceleration range of the design response spectra are larger than those for the constant velocity range of those. This trend is contrary to the results obtained from several recent studies and may lead to underestimates of the high-damped design response spectra. This paper points out the issue and suggests further examinations of the factor in the constant acceleration region with potential revision to design practice.

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16

Willison, Charley E., Phillip M. Singer, Melissa S. Creary, and Scott L. Greer. "Quantifying inequities in US federal response to hurricane disaster in Texas and Florida compared with Puerto Rico." BMJ Global Health 4, no. 1 (January 2019): e001191. http://dx.doi.org/10.1136/bmjgh-2018-001191.

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If disaster responses vary in their effectiveness across communities, health equity is affected. This paper aims to evaluate and describe variation in the federal disaster responses to 2017 Hurricanes Harvey, Irma and Maria, compared with the need and severity of storm damage through a retrospective analysis. Our analysis spans from landfall to 6 months after landfall for each hurricane. To examine differences in disaster responses across the hurricanes, we focus on measures of federal spending, federal resources distributed and direct and indirect storm-mortality counts. Federal spending estimates come from congressional appropriations and Federal Emergency Management Agency (FEMA) records. Resource estimates come from FEMA documents and news releases. Mortality counts come from National Oceanic and Atmospheric Administration (NOAA) reports, respective vital statistics offices and news articles. Damage estimates came from NOAA reports. In each case, we compare the responses and the severity at critical time points after the storm based on FEMA time logs. Our results show that the federal government responded on a larger scale and much more quickly across measures of federal money and staffing to Hurricanes Harvey and Irma in Texas and Florida, compared with Hurricane Maria in Puerto Rico. The variation in the responses was not commensurate with storm severity and need after landfall in the case of Puerto Rico compared with Texas and Florida. Assuming that disaster responses should be at least commensurate to the degree of storm severity and need of the population, the insufficient response received by Puerto Rico raises concern for growth in health disparities and increases in adverse health outcomes.

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17

García Moreno, D., and T. Camelbeeck. "Comparison of ground motions estimated from prediction equations and from observed damage during the M = 4.6 1983 Liège earthquake (Belgium)." Natural Hazards and Earth System Sciences 13, no. 8 (August 7, 2013): 1983–97. http://dx.doi.org/10.5194/nhess-13-1983-2013.

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Abstract. On 8 November 1983 an earthquake of magnitude 4.6 damaged more than 16 000 buildings in the region of Liège (Belgium). The extraordinary damage produced by this earthquake, considering its moderate magnitude, is extremely well documented, giving the opportunity to compare the consequences of a recent moderate earthquake in a typical old city of Western Europe with scenarios obtained by combining strong ground motions and vulnerability modelling. The present study compares 0.3 s spectral accelerations estimated from ground motion prediction equations typically used in Western Europe with those obtained locally by applying the statistical distribution of damaged masonry buildings to two fragility curves, one derived from the HAZUS programme of FEMA (FEMA, 1999) and another developed for high-vulnerability buildings by Lang and Bachmann (2004), and to a method proposed by Faccioli et al. (1999) relating the seismic vulnerability of buildings to the damage and ground motions. The results of this comparison reveal good agreement between maxima spectral accelerations calculated from these vulnerability and fragility curves and those predicted from attenuation law equations, suggesting peak ground accelerations for the epicentral area of the 1983 earthquake of 0.13–0.20 g (g: gravitational acceleration).

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Grupo de trabajo SESPAS-OMC sobre i, Grupo de trabajo SESPAS-OMC sobre i. "Documento del grupo de trabajo SESPAS-OMC sobre iatrogenia." Revista de la Fundación Educación Médica 20, no. 6 (2017): 255. http://dx.doi.org/10.33588/fem.206.925.

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Gual, Arcadi. "El General Medical Council revisa un documento clave: Tomorrow’s Doctors." Revista de la Fundación Educación Médica 12, no. 3 (2009): 125. http://dx.doi.org/10.33588/fem.123.521.

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Terán-Gilmore, Amador, Oscar Zuñiga-Cuevas, and Jorge Ruiz-García. "Displacement-Based Seismic Assessment of Low-Height Confined Masonry Buildings." Earthquake Spectra 25, no. 2 (May 2009): 439–64. http://dx.doi.org/10.1193/1.3111149.

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This paper presents a practical displacement-based evaluation procedure for the seismic assessment of low-height regular confined masonry buildings. First, the so-called Coefficient Method established in several FEMA documents is adapted to obtain rapid estimates of inelastic roof displacement demands for regular confined masonry buildings. For that purpose, a statistical study of constant relative strength inelastic displacement ratios of single-degree-of-freedom systems representing confined masonry buildings is carried out. Second, a nonlinear simplified model is introduced to perform pushover analysis of regular confined masonry buildings whose global and local behavior is dominated by shear deformations in the masonry walls. The model, which can be applied through the use of commercial software, can be used to establish the capacity curve of such buildings. Finally, the evaluation procedure is applied to a three-story building tested at a shaking table testing facility.

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Probst, Peter. "Addenda & Corrigenda zu: Marco Traverso, Esercito romano e società italica in età imperiale. I. I documenti epigrafici." Frankfurter elektronische Rundschau zur Altertumskunde, no. 12 (July 26, 2016): 12–28. http://dx.doi.org/10.21248/fera.12.44.

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Liu, Meng, and Yuxiang Li. "Global generalized solutions of a haptotaxis model describing cancer cells invasion and metastatic spread." Communications on Pure & Applied Analysis 21, no. 3 (2022): 927. http://dx.doi.org/10.3934/cpaa.2022004.

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In this paper, we consider the following haptotaxis model describing cancer cells invasion and metastatic spread<disp-formula> <label/> <tex-math id="FE1a"> \begin{document}$\begin{array}{*{20}{c}}{\left\{ {\begin{array}{*{20}{l}}{{u_t} = \Delta u - \chi \nabla \cdot (u\nabla w),}&{x \in \Omega ,\;t > 0,}\\{{v_t} = {d_v}\Delta v - \xi \nabla \cdot (v\nabla w),}&{x \in \Omega ,\;t > 0,}\\{{m_t} = {d_m}\Delta m + u - m,}&{x \in \Omega ,\;t > 0,}\\{{w_t} = - \left( {{\gamma _1}u + m} \right)w,}&{x \in \Omega ,\;t > 0,}\end{array}} \right.}&{(0.1)}\end{array}$ \end{document} </tex-math></disp-formula>where <inline-formula><tex-math id="M1">\begin{document}$ \Omega\subset \mathbb{R}^3 $\end{document}</tex-math></inline-formula> is a bounded domain with smooth boundary and the parameters <inline-formula><tex-math id="M2">\begin{document}$ \chi, \xi, d_{v}, d_{m},\gamma_{1}>0 $\end{document}</tex-math></inline-formula>. Under homogeneous boundary conditions of Neumann type for <inline-formula><tex-math id="M3">\begin{document}$ u $\end{document}</tex-math></inline-formula>, <inline-formula><tex-math id="M4">\begin{document}$ v $\end{document}</tex-math></inline-formula>, <inline-formula><tex-math id="M5">\begin{document}$ m $\end{document}</tex-math></inline-formula> and <inline-formula><tex-math id="M6">\begin{document}$ w $\end{document}</tex-math></inline-formula>, it is proved that, for suitable smooth initial data <inline-formula><tex-math id="M7">\begin{document}$ (u_0, v_0, m_0, w_0) $\end{document}</tex-math></inline-formula>, the corresponding Neumann initial-boundary value problem possesses a global generalized solution.

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Medina-González, José Humberto. "Antología de documentos para la historia de la arqueología de Teotihuacan." FIGURAS REVISTA ACADÉMICA DE INVESTIGACIÓN 4, no. 1 (November 1, 2022): 92–97. http://dx.doi.org/10.22201/fesa.26832917e.2022.4.1.239.

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Esta reseña rescata la obra documental más importante del arqueólogo Roberto Gallegos Ruiz quien se encargó de recopilar una serie de textos que tratan de la zona arqueológica de Teotihuacan que van desde el siglo XVI hasta el siglo XX.

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Delshad, Vahid, Negar Pourvakhshoori, Elham Rajabi, Jafar Bazyar, and Hamid Reza Khankeh. "International Agreements on Disaster Risk Management Based on World Conferences, Successful or Not: A Review Study." Health in Emergencies & Disasters Quarterly 6, no. 1 (October 1, 2020): 1–8. http://dx.doi.org/10.32598/hdq.6.1.38.4.

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Background: At the end of the 19th century, international communities have realized the necessity of global planning and cooperation. Accordingly, worldwide meetings have been organized for several years. This study aims to assess the achievement of predetermined objectives by international conferences in the field of risk management. Materials and Methods: The search for articles and documents was done using several keywords of "international meetings", "Sendai", "Hyogo", and "Yokohama" in Scopus, Web of Science, PubMed, Cochrane Library, Science Direct, Google Scholar databases. Also, the risk management domain websites such as FEMA, UNISDR, and EM-Date were searched. Results: Three Disaster World Conferences have been organized, hosted by Japan: Yokohama 1994, Kobe 2005, and Sendai 2015. They proposed strategies and prioritized actions for managing disaster risk, reducing the risk of disasters, and coping with disasters. In the second and third conferences, as requested by the United Nations (UN General Assembly), the UN Office for Disaster Risk Reduction (UNISDR) helped as the coordinating body. Conclusion: Reducing the risks of disasters is a global issue, which needs international cooperation. Therefore, all countries should take steps to achieve disaster risk reduction goals. Since declaraions, documents, resolutions, and conferences do not impose an obligation on countries in this regard, the success rate of the programs is dependent on voluntary international cooperation. Moreover, while we do not expect that outcomes of these international agreements related to disaster risk reduction be achieved at the scheduled time plan, strengthening the international cooperation of the countries to facilitate the improvement of actions and programs would be effective.

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Hu, Die, Xianhua Tang, and Qi Zhang. "Existence of solutions for a class of quasilinear Schrödinger equation with a Kirchhoff-type." Communications on Pure & Applied Analysis 21, no. 3 (2022): 1071. http://dx.doi.org/10.3934/cpaa.2022010.

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In this paper, we discuss the generalized quasilinear Schrödinger equation with Kirchhoff-type:<disp-formula> <label/> <tex-math id="FE1a"> \begin{document}$\left (1\!+\!b\int_{\mathbb{R}^{3}}g^{2}(u)|\nabla u|^{2} dx \right) \left[-\mathrm{div} \left(g^{2}(u)\nabla u\right)\!+\!g(u)g'(u)|\nabla u|^{2}\right] \!+\!V(x)u\! = \!f( u),(\rm P)$ \end{document} </tex-math></disp-formula>where <inline-formula><tex-math id="M1">\begin{document}$ b>0 $\end{document}</tex-math></inline-formula> is a parameter, <inline-formula><tex-math id="M2">\begin{document}$ g\in \mathbb{C}^{1}(\mathbb{R},\mathbb{R}^{+}) $\end{document}</tex-math></inline-formula>, <inline-formula><tex-math id="M3">\begin{document}$ V\in \mathbb{C}^{1}(\mathbb{R}^3,\mathbb{R}) $\end{document}</tex-math></inline-formula> and <inline-formula><tex-math id="M4">\begin{document}$ f\in \mathbb{C}(\mathbb{R},\mathbb{R}) $\end{document}</tex-math></inline-formula>. Under some "Berestycki-Lions type assumptions" on the nonlinearity <inline-formula><tex-math id="M5">\begin{document}$ f $\end{document}</tex-math></inline-formula> which are almost necessary, we prove that problem <inline-formula><tex-math id="M6">\begin{document}$ (\rm P) $\end{document}</tex-math></inline-formula> has a nontrivial solution <inline-formula><tex-math id="M7">\begin{document}$ \bar{u}\in H^{1}(\mathbb{R}^{3}) $\end{document}</tex-math></inline-formula> such that <inline-formula><tex-math id="M8">\begin{document}$ \bar{v} = G(\bar{u}) $\end{document}</tex-math></inline-formula> is a ground state solution of the following problem<disp-formula> <label/> <tex-math id="FE1b"> \begin{document}$-\left(1+b\int_{\mathbb{R}^{3}} |\nabla v|^{2} dx \right) \triangle v+V(x)\frac{G^{-1}(v)}{g(G^{-1}(v))} = \frac{f(G^{-1}(v))}{g(G^{-1}(v))},(\rm \bar{P})$ \end{document} </tex-math></disp-formula>where <inline-formula><tex-math id="M9">\begin{document}$ G(t): = \int_{0}^{t} g(s) ds $\end{document}</tex-math></inline-formula>. We also give a minimax characterization for the ground state solution <inline-formula><tex-math id="M10">\begin{document}$ \bar{v} $\end{document}</tex-math></inline-formula>.

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26

Fernández Rodríguez, Carmen María. "«I often thought if it could not be dissolved, it could only with life be extirpated»: a translemic analysis and Spanish translation of Frances Burney’s Letter from Frances Burney to her sister Esther about her mastectomy without anaesthetic, 1812." Feminismo/s, no. 39 (January 3, 2022): 59. http://dx.doi.org/10.14198/fem.2022.39.03.

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Frances Burney (1752-1840) was one of the most influential eighteenth-century British novelists. Apart from the novel, Burney also cultivated the theatre and she wrote texts of a marked political nature on the French Revolution, a fact that is not so well– known by the general public. This article is inscribed within the framework of gender studies and the so-called Burney Studies and aims to analyze Letter from Frances Burney to Her Sister Esther About her Mastectomy Without Anaesthetic, 1812. By its subject, the document is an account of current interest for both medicine and feminism. Here Letter Here Letter is studied from the perspective of translation studies, specifically taking Itamar Even-Zohar’s theory of literary polisystems and various translation strategies as a methodological reference. We will examine the configuration of the key elements of Even-Zohar’s approach and various translation strategies as a methodological reference in this text which we will approach translation studies as a pathography, insisting on the identification between female subject and writing, Burney’s courage in confronting the disease and the particular relationship she establishes with the participants in the story and the impact that disease has on those around and helping her. Finally, the Spanish translation of Letter is offered, so Spanish-speaking readers have access to this document recently digitized by The British Library. Letter is a chronicle of pain, but also of courage and a real lesson in the intimate relationship between women and writing that was always so important to Burney. This study also means a re-vision of the writer that is far from what we could have until now.

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Nikolay SAMOYLOV. "Early 20th Century Reforms in Qing China Through the Eyes of Russian Diplomats (Based on Documents From the Russian State Historical Archive)." Far Eastern Affairs 51, no. 001 (March 31, 2023): 140–60. http://dx.doi.org/10.21557/fea.84179971.

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Nikolay SAMOYLOV. "Early 20th Century Reforms in Qing China Through the Eyes of Russian Diplomats (Based on Documents From the Russian State Historical Archive)." Far Eastern Affairs 51, no. 001 (March 31, 2023): 140–60. http://dx.doi.org/10.21557/fea.84942193.

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Dan, Wood AO. "Transforming the Business of Gold Exploration: Adapting to Deeper Exploration." SEG Discovery, no. 112 (January 1, 2018): 1–14. http://dx.doi.org/10.5382/segnews.2018-112.fea.

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Note: This article is condensed from a keynote address, Transforming the Business of Gold Exploration, presented at the NewGen-Gold 2017 Conference in Perth, Australia, on November 14, 2017. Permission to adapt the published article was kindly provided by Keith Yates & Associates Pty Ltd and Paydirt Media Pty Ltd. NewGenGold conferences have been held every two years since 1995 to document case histories of discovery and to provide exploration geologists with valuable insights into the discovery process.

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Bahrami, Nazli, Torill Sauer, Siri Engebretsen, Belal Aljabri, Vahid Bemanian, Jonas Lindstrøm, Torben Lüders, et al. "The NEOLETEXE trial: a neoadjuvant cross-over study exploring the lack of cross resistance between aromatase inhibitors." Future Oncology 15, no. 32 (November 2019): 3675–82. http://dx.doi.org/10.2217/fon-2019-0258.

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The aromatase inhibitor letrozole (Femar®/Femara®) and the aromatase inactivator exemestane (Aromasin®) differ in their biochemical effect on the aromatase enzyme. Letrozole is a competitive aromatase inhibitor while exemestane binds irreversibly to the aromatase enzyme. This pharmacological difference is of clinical interest since a lack of cross-resistance has been documented. It has been demonstrated in several clinical trials that exemestane may cause a disease regression following resistance to nonsteroidal aromatase inhibitors. The exact mechanism(s) behind this phenomenon is yet unknown. Here, we present the NEOLETEXE trial with the aim of exploring the individual mechanisms involved behind the observed lack of cross resistance. Clinical trial registration: The trial has been approved by the Regional Ethics Committee of South-East Norway (project number 2015/84).

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Moreira, Diego Gouveia. "Liberdade de Gênero, programa do GNT, e a instauração de novos processos de subjetivação ligados à transgeneridade." Fronteiras - estudos midiáticos 23, no. 2 (September 14, 2021): 234–44. http://dx.doi.org/10.4013/fem.2021.232.16.

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A televisão opera como um dispositivo (Foucault, 2001), sendo responsável pelo estabelecimento de processos de subjetivação que determinam modos de interpretar a realidade. Um tema que tem ganhado novas abordagens em programas televisivos e, assim, vem contribuindo para novos entendimentos é o da transgeneridade. O Liberdade de Gênero (2016-2017), uma dessas iniciativas, constituiu uma série documental do GNT com foco em pessoas trans. O objetivo deste artigo é estudar como as enunciações do programa configuram um acontecimento discursivo que contribuiu para constituição de novas subjetivações em torno das questões de gênero. A partir de teorias sobre discurso e subjetivação, considera-se que o programa avança no tratamento dado pela televisão a pessoas transgêneras, contribuindo para novas formas de se entender o assunto. Palavras-chave Televisão. Transgeneridade. Subjetivação.

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Martínez-García, Patricia. "Cuando las mujeres acceden al poder. Discriminaciones y resistencias en las comunidades marineras." Feminismo/s, no. 33 (June 1, 2019): 171. http://dx.doi.org/10.14198/fem.2019.33.07.

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Las trabajadoras del mar y, en concreto, las mariscadoras a pie, se han convertido en un agente fundamental en el impulso de cambios en las comunidades pesqueras. Desde su profesionalización en Galicia en los años 90, se han sucedido transformaciones en su posición económica, política y social. Desde la marginación y la falta de reconocimiento se han consolidado como referentes de nuevas formas de organización y dinamización de sus comunidades. De manera que el objetivo de este trabajo es analizar las experiencias de participación de las mariscadoras a pie en las organizaciones pesqueras. A través de una metodología cualitativa, sustentada en el análisis documental y en la realización de entrevistas en profundidad, se atiende a las discriminaciones que han vivido y a las estrategias que han desarrollado para sobrevivir, muchas veces, en un entorno hostil.

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Fauzan, Fauzan, Khin Thu Zar Htay, Zawil Huda, Hafiz Oktaufik, and Geby Aryo Agista. "Effect of tsunami load on the elementary school building of the 23/24 Padang, Indonesia." E3S Web of Conferences 331 (2021): 07016. http://dx.doi.org/10.1051/e3sconf/202133107016.

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West Sumatra Province is one of the provinces in Indonesia that is vulnerable to natural disasters, especially earthquakes and tsunamis. Padang city, as the capital city of West Sumatra, is an area that is included in an area with a high level of vulnerability (High Risk Zone) to tsunamis. Therefore, the construction of public buildings such as hospitals, government offices, and school buildings must have certain technical engineering that is able to anticipate the damage and collapse of buildings due to the earthquake and tsunami. One of the public buildings as an educational facility in Padang city is the Elementary School building of the 23/24 (SD 23/24 Padang), located close to the beach. Based on the evaluation results of the Detail Engineering Design (DED) documents, it is found that this building was designed without taking into account the tsunami loads. Therefore, a building assessment should be carried out to check the capacity of the building to resist the working loads, including the tsunami loads, and to investigate the effect of the tsunami loads on the SD 23/24 Padang building. In this study, the building was analyzed using ETABS v.18 software based on the new Indonesian Seismic Code, SNI 1726-2019 for seismic load and FEMA P646-2019 for calculating tsunami loads. The results show that the SD 23/24 Padang building is strong against earthquake loads, but it doesn’t have enough capacity when tsunami loads are applied, in which there are several structural elements (columns/beams) that do not have sufficient capacity to withstand the combined earthquake and tsunami loads. The effect of tsunami loads on the building structure is also discussed in this paper.

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Kimura, Reo, Haruo Hayashi, Shingo Suzuki, Kosuke Kobayashi, Kenshin Urabe, Satoshi Inoue, and Takahiro Nishino. "Systematization and Sharing of Disaster Management Literacy by DMLH." Journal of Disaster Research 9, no. 2 (March 1, 2014): 176–87. http://dx.doi.org/10.20965/jdr.2014.p0176.

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The concept we propose for a disaster management literacy hub (DMLH) involves systemizing and generalizing disaster management literacy (DML) and discussing how to design such a DMLH where the general public and disaster responders share materials on DML. In the early 21stcentury, measures against large-scale earthquakes should essentially include both hardware disaster mitigation measures like the construction of appropriate structures and software measures like disaster preparedness among people and organizations such as the general public, disaster responders and related organizations. We define knowledge about disaster response management and competency as DML. Our analysis of documents on the incident command system (ICS), an emergency response system under the United States Federal Emergency Management Agency (FEMA), found 56 positions of disaster responders in ICS defined by 35 actions required for four types of disaster response competency. The above analysis led us to propose that DML consist of three elements: knowledge for learning about disaster management and mitigation, skills required for effective disaster response, and basic competency and attitudes for coping with disasters. For conceptual DMLH design based on the Instructional Design (ID), we propose three types of learning:1 The general public and disaster responders learn audiovisually using training videos and materials and review tests on learn from videos.2 People who want to provide education and training at schools or in regions or municipalities with school teacher guidance/teaching plans learn how to do so.3 People learn DML by posting or searching for (collecting and arranging) materials.We discuss how to publish such learning programs, taking as a specific example a life reconstruction support system (to put disaster victims’ lives back in order) based on victims’ master database.

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Goicoechea Gaona, María Ángeles, María José Clavo Sebastián, and Remedios Álvarez Terán. "Feminismo y derechos para las mujeres homosexuales." Feminismo/s, no. 33 (June 1, 2019): 297. http://dx.doi.org/10.14198/fem.2019.33.12.

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Este trabajo forma parte de una investigación que venimos desarrollando desde 2014 sobre las mujeres homosexuales en España, a partir de 41 entrevistas en profundidad. En este caso, se centra en las dificultades de inclusión asociadas a la homosexualidad y el grado de compromiso social y político que de ellas se derivan. Desde el marco teórico del feminismo, se combina la reflexión documental y bibliográfica sobre la diversidad afectiva, sexual y de género con los testimonios de las entrevistadas. La manera de manifestarse como mujer homosexual es muy plural, como es diversa la autodenominación. No todas se sienten deudoras del feminismo, y entre las que sí son militantes también hay muchos matices. Las reivindicaciones personales se vuelven políticas gracias a los movimientos organizados, aunque muchas de sus necesidades permanecen con frecuencia ajenas a las agendas políticas.

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Aliyu, Dr Saeedat Bolajoko. "Nigerian Popular Music: Social Mediation Amid Musicality." International Journal of Research and Innovation in Social Science 06, no. 06 (2022): 578–81. http://dx.doi.org/10.47772/ijriss.2022.6614.

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Music is a fundamental feature of the African society. One of its indispensable values is its entertainment function. Music has also been used overtime to engender positive social changes in the society. Using this popular medium, traditional African musicians and poets have used their composing ingenuity not only to please their audience but also to lampoon, satirize, moralize, preach and call for individual and collective changes or conformity to established social, religious, or cultural norms, as the circumstances dictate. In Nigeria’s recent past, the late Fela Anikulapo- Kuti, Sunny Okosun, Ebenezer Obey, and Osita Osadebe are examples of musicians who used their music to comment on the challenges of life in Nigeria and elsewhere. They also gained popularity from the entertainment value of their various kinds of music. However, commercialisation brought about by the realities of the socio-political and economic conditions of life seems to have made the music of emerging Nigerian musicians lose social relevance. This article studies via document analysis the thematic trends in some of the songs of Asa, a popular Nigerian musician who has received wide acclaim across the world. This paper concludes that social relevance and commercial success are two states which can be achieved simultaneously by emerging Nigerian musicians without apprehension, especially in a world which rates commercial success as a parameter for popularity.

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Gruszynski, Ana Cláudia, Cristiane Lindemann, and Gabriela Gruszynski Sanseverino. "Vozes & audiovisual: a crise do coronavírus e a cobertura do The Intercept Brasil no Instagram." Fronteiras - estudos midiáticos 23, no. 1 (April 26, 2021): 129–45. http://dx.doi.org/10.4013/fem.2021.231.11.

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O estudo toma como objeto empírico a cobertura do The Intercept Brasil (TIB) sobre o Coronavírus publicada como stories no Instagram com o objetivo de compreender como diferentes vozes são incorporadas nos conteúdos audiovisuais produzidos. O corpus foi composto por nove destaques presentes em seu perfil, totalizando 260 stories. Com base na pesquisa bibliográfica foram estabelecidos os parâmetros de análise e a pesquisa documental orientou a contextualização do objeto empírico, em abordagem qualitativa. Observou-se que as narrativas promovem a confiança e credibilidade no que é narrado a partir do olhar de testemunha que a câmera subjetiva aciona, levando o público a percorrer ambientes, observar locais e pessoas, interagir com sujeitos, constituindo registros de referencialidade reforçados pelo som direto. Os recursos de edição com a inserção de elementos textuais garantem o entendimento do que se passa sem o áudio ativado. A valorização de diferentes contribuições está alinhada com a proposta editorial do veículo e revela características como horizontalidade, participação e engajamento dos usuários. Os stories são utilizados para contar histórias, não servindo apenas como um modo de redirecionamento para seu site. A cobertura dá visibilidade a realidades que não costumam ganhar espaço em modelos de negócios tradicionais e foi impulsionada para o/no Instagram pelo cenário de pandemia e isolamento social. Palavras-chave: Audiovisual. The Intercept Brasil. Conteúdo gerado pelo usuário. Instagram. Coronavírus.

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Garrido, Elisa. "Arte, botánica y género: sobre el manuscrito extraviado de Nancy Anne Kingsbury Wollstonecraft." Feminismo/s, no. 40 (July 15, 2022): 211. http://dx.doi.org/10.14198/fem.2022.40.09.

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Nancy Anne Kingsbury Wollstonecraft (c.1791-1828) fue la autora de un extenso tratado botánico, realizado durante el siglo XIX, sobre las plantas y frutos de la isla de Cuba que nunca fue publicado. Aunque existían referencias sobre el mismo, nunca se había hallado, por lo que se consideraba perdido hasta que, en 2018, el departamento Rare and Manuscript Collections de la Biblioteca de la Universidad de Cornell digitalizó el documento, haciéndolo público y abriendo nuevas vías de investigación sobre las mujeres naturalistas e ilustradoras. Kingsbury Wollstonecraft residió en la provincia cubana de Matanzas durante la década de 1820. Comenzó a estudiar la vida vegetal de la isla de Cuba, por entonces bajo dominación española, llevando a cabo una extensa investigación sobre la naturaleza de la región. Su trabajo fue recopilado en un manuscrito, ilustrado por ella misma, con más de un centenar de láminas botánicas. Aunque realizó las gestiones para publicarlo, se encontró con una serie de dificultades que lo impidieron, pasando desapercibido durante casi dos siglos después de su muerte. La invisibilización de su obra se nos presenta como un paradigma de las dificultades que encontraron las mujeres que trataron de producir conocimiento científico, más allá de los espacios que les eran afines, y nos permite explorar distintas perspectivas sobre las relaciones intrínsecas entre la botánica, lo femenino, la naturaleza y el contexto colonial. En el artículo se analiza, en primer lugar, el papel esencial que tuvo el arte y la ilustración para que las mujeres consiguieran derribar algunas de las barreras de género que les impedían entrar a formar parte de las comunidades científicas, destacando sus aportaciones a la botánica. A continuación, nos centramos en Kingsbury Wollstonecraft como caso de estudio y planteamos algunos de los argumentos que justificaron la invisibilización de su trabajo, aportando una serie de reflexiones sobre la normatividad del relato científico que, bajo una supuesta objetividad, excluía del mismo las diversas formas –íntimas, poéticas o artísticas– que la narrativa femenina tenía de aproximarse al estudio de la naturaleza.

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Aranda Bernal, Ana María. "Maternal rule. Affection, power, and patrimony expressed through testamentary wills (15th-16th centuries)." Feminismo/s, no. 41 (January 2, 2023): 21. http://dx.doi.org/10.14198/fem.2023.41.02.

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«Maternal rule» is the expression used by a Spanish noblewoman from the kingdom of Seville in her last will and testament, written in the 16th century, to justify the authority she holds over her children. Based on the hypothesis that this is not merely her own individual perception, but rather that it corresponds to her experiences living within a specific emotional community, this paper carries out a comparative analysis with the testaments of two other women from the same territory and social group, with a view to understanding their maternal affective experiences. The documentation examined spans almost a century and includes information and instructions that characterise the lives and lifestyles of three women: María de Mendoza (+1493), Catalina de Ribera (+1505), and María Andrea Coronel de Guzmán y Sotomayor (+1589). However, they are written from the subjective perspective of a woman facing death, who wishes to retain her influence and at times control over her children even after she has disappeared from their lives, reflecting on her own soul. The main conclusions reached would indicate that they belonged to the same emotional community: Christian, aristocratic, with a gender role assignation that did not prevent them from exercising rule in certain areas, especially when they became widowed and gained authority over their children. However, they experience motherhood differently depending on whether their children are adults or still minors as the mothers face death. But above all, the way in which they exercise their motherhood is influenced by their personalities and predisposition. In any case, they use their last will and testament to give orders and advice to their descendants through a language that shows their motherly affections and disaffections. These are documents through which they can settle emotional scores through their legacies with a view to expressly leaving their children on the same or different footings. And, finally, beyond biological motherhood, we see how the caregiving role taken on by these women extends through affection or responsibility to other members of the social group.

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Kubíček, Petr, Jaromír Drápala, and P. Wostrý. "Evaluation of Concentration Dependent Diffusivities of Manganese in the Diffusion Joint Fe/FeMn-Steel by Means of Mathematical-Analytical Methods." Defect and Diffusion Forum 283-286 (March 2009): 214–19. http://dx.doi.org/10.4028/www.scientific.net/ddf.283-286.214.

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When developing new types of materials with special properties for the automotive industry, steels with high content of manganese (up to 25 wt. % Mn) were studied. These steels embody increased failure resistance, high level of deformation hardening, plastic response and high value of energy absorption in crash situations [1,2]. The aim of our work was to study an interaction of a FeMn alloy with pure iron from the view of diffusion processes. For that purpose, diffusion joints Fe/FeMn-steel were created and long-term heated at the temperatures of 800, 900 and 1050 °C. Dependences of diffusivities of Mn on its concentration were calculated from concentration profiles of manganese after diffusion heating applying three analytical methods. In the first method, constant values of diffusivities Di, i = 1,2 for both Fe and steel were taken into account. In the second case a modified Matano-Boltzmann method utilizing polynomials was applied, which simplifies solution in numerous cases. The third method performs the solution of the non-linear equation of diffusion on the assumption of a linear dependence of diffusivity on concentration applying a procedure based on perturbation calculus. The results of the solution will be graphically documented in details together with the description of experiments.

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Cunha e Cruz, Marco Aurélio Rodrigues da, Robison Tramontina, and Grazieli Ana Paula Schmitz. "Maria do Rosário vs. Jair Bolsonaro: uma leitura (anti) democrática do Inquérito Penal n. 3.932." Espaço Jurídico Journal of Law [EJJL] 19, no. 2 (August 16, 2018): 553–80. http://dx.doi.org/10.18593/ejjl.v19i2.17688.

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No presente trabalho teve-se por objetivo analisar, em forma de estudo de caso, algumas projeções (anti)democráticas da frase desferida pelo deputado federal Jair Bolsonaro em direção à igualmente deputada federal Maria do Rosário: “Não merece porque ela é muito ruim, porque ela é muito feia, não faz meu gênero, jamais a estupraria. Eu não sou estuprador, mas, se fosse, não iria estuprar, porque não merece.” Essa frase deu ensejo a uma ação de natureza civil e ao Inquérito Penal n. 3.932, em trâmite no Supremo Tribunal Federal, objeto deste escrito. Neste texto, o estudo do Inquérito Penal n. 3.932 é lido com as lentes das obras Desonra, de J. M. Coetzee, e Sobre a Democracia, de Robert Dahl. Esse diálogo visa não somente fazer uma ligação entre as obras, mas demonstrar como a honra masculina é ponto forte e presente na questão da diferenciação do homem em relação à mulher. Empregando o método lógico-dedutivo, foi realizada uma pesquisa teórica, de cunho descritivo, com o levantamento bibliográfico e documental, buscando a análise e interpretação do referencial teórico e do caso em apreço.

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Andrade, Mateus Dias, Patrícia Carla Santos, Juni Cordeiro, Cibele Andrade de Alvarenga, Charles Ianne Ferreira dos Santos, and José Luiz Cordeiro. "Análise da destinação de resíduos sólidos industriais no Estado de Minas Gerais entre os anos de 2011 e 2016." Research, Society and Development 8, no. 3 (December 21, 2018): e2383855. http://dx.doi.org/10.33448/rsd-v8i3.855.

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O crescimento da economia contribui para o desenvolvimento de processos produtivos, aumentando, consequentemente, a geração de resíduos, que por sua vez demandam um gerenciamento adequado de forma a minimizar os impactos negativos envolvendo a sua disposição no meio ambiente. Assim, este trabalho objetivou analisar a destinação dos resíduos sólidos industriais no Estado de Minas Gerais entre os anos de 2011 e 2016. Para tal, utilizou-se uma abordagem quantitativa, empregando a pesquisa documental baseada nos Inventários de Destinação de Resíduos Sólidos Industriais de Minas Gerais elaborado pela Fundação Estadual de Meio Ambiente (FEAM), referente aos anos de 2011 a 2016. Verificou-se que houve redução na quantidade gerada de resíduos, de cerca de 210,9 milhões de toneladas em 2011 para 49,3 milhões de toneladas em 2016. Percebeu-se que as formas mais utilizadas de destinação foram a fertirrigação, caldeira, reutilização externa, reciclagens interna e externa, barragem de rejeito e incorporação em solo agrícola. Neste contexto, destaca-se a importância relacionada à compreensão adequada do processo produtivo, seus impactos negativos e a busca contínua por estratégias e ações que minimizem tais efeitos, visando a conformidade com a legislação vigente e o reaproveitamento de materiais.

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Acosta, Marina. "Aborto y participación política en la etiqueta #28S en Argentina." Feminismo/s, no. 39 (January 3, 2022): 13. http://dx.doi.org/10.14198/fem.2022.39.01.

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El feminismo es uno de los movimientos sociales que más relevancia ha cobrado en el contexto mundial en los últimos tiempos. Con una larga historia de lucha, las mujeres son portadoras de demandas que se vertebran en disputas articuladas tanto en premisas de reconocimiento como de redistribución. La participación de muchas mujeres jóvenes en las movilizaciones del #NiUnaMenos obligó al feminismo a apelar a otras formas de comunicación y servirse de las plataformas digitales para organizar la protesta social. Las redes sociales le han proporcionado al colectivo una plataforma para visibilizar sus reclamos y demandas globales. En el Día Internacional por el Aborto Seguro, la Campaña Nacional por el Derecho al Aborto legal, seguro y gratuito lanzó en Argentina la etiqueta #28S con el fin de presionar a los tomadores de decisión en la discusión formal sobre el aborto. La etiqueta arropó los sentires y opiniones de muchos/as ciudadanos/as preocupados/as por la problemática. Como en general ocurre con el activism hashtag los/las usuarios/as crearon un conjunto de narrativas de petición, demandas y protestas. El objetivo de la investigación es analizar la conversación digital en el hashtag para dar cuenta de la dinámica comunicacional de los/las usuarios/as que participaron de ella, describir sus interacciones e identificar sus narrativas. Además de la clásica revisión bibliográfica, la propuesta cuali-cuantitativa del estudio es exploratoria y descriptiva. Se aplica el método cuantitativo del análisis de contenido y el método cualitativo del análisis documental. Dentro de los principales resultados destaca que las cuentas más activas pertenecen a usuarios/as con poca cantidad de seguidores que escriben a título personal, los líderes de opinión crean los contenidos alrededor de los cuales se produce la interacción y en sus publicaciones los/las usuarios/as retoman los encuadres activados por la Campaña en sus documentos.

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Pollak, Cheryl L. ""Hurricane" Sandy." Texas A&M Journal of Property Law 5, no. 2 (December 2018): 157–92. http://dx.doi.org/10.37419/jpl.v5.i2.3.

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On the evening of October 29, 2012, “Hurricane” Sandy made land- fall on the New York coastline, battering the land with strong winds, torrential rain, and record-breaking storm surges. Homes and commercial structures were destroyed; roads and tunnels were flooded; and more than 23,000 people sought refuge in temporary shelters, with many others facing weeks without power and electricity. At the time, Sandy was heralded as one of the costliest hurricanes in the his- tory of the United States; the second costliest hurricane only to Katrina, which hit New Orleans in 2005. Unfortunately, recent experience with Hurricanes Florence, Maria, Harvey, and Irma suggest that this pattern of devastating superstorms may become the new norm as climate change produces more extreme and unpredictable weather events. In Sandy’s aftermath, as individuals returned to their homes, or what remained of them, and communities began to rebuild, the true cost of the storm became apparent. A year after the storm, the Federal Emergency Management Agency (“FEMA”) estimated that over $1.4 billion in assistance was provided to 182,000 survivors of the dis- aster; another $3.2 billion was provided to state and local governments for debris removal, infrastructure repair, and emergency protective measures. More than $2.4 billion was provided to individuals and businesses in the form of low-interest loans through the Small Business Administration (“SBA”), and millions more were spent on grants de- signed to implement mitigation measures in the future and to provide unemployment assistance to survivors. Before the storm, homeowners paid premiums for flood insurance provided through the National Flood Insurance Program (“NFIP”), and for homeowner’s insurance provided by dozens of private insurers. In the months following the storm, they began to file claims for assistance in rebuilding their homes. While many such claims were re- solved successfully, many homeowners were unhappy with the settlement amounts offered by their insurance carriers and felt compelled to file lawsuits in the surrounding state and federal courts. Many of those lawsuits were filed in the United States District Court for the Eastern District of New York (“EDNY”). This case study describes the EDNY’s specifically crafted, unique approach to handling the mass litigation that ensued from Sandy’s devastation, documents some of the problems that the Court faced during that mass litigation, and describes some of the lessons learned from the Court’s experience.

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Çelebi, Nurhayat, Hatice Tezer Asan, and Engin Asan. "Meşrutiyet Döneminde Asker-Vatandaş Yetiştirme Anlayışı Çerçevesinde Paramiliter Gençlik Örgütleri / Paramilitary Youth Organizations within the Framework of Training Citizen-Militia Conception in the Second Constitutional Period." Journal of History Culture and Art Research 7, no. 2 (July 2, 2018): 502. http://dx.doi.org/10.7596/taksad.v7i2.1426.

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AbstractIn this study, the struggle against paramilitary organizations and associations founded during the Second Constitutional period when the conception of nation-state and the concept of citizen-militia gained momentum in European states has been scrutinized. The research is a qualitative study based on a document analysis. After the traumas of wars in the Ottoman Empire, which entered the process of rapidly losing the lands spreading over three continents, the education mentality has been re-examined within the framework of citizenship conception. In addition to these inquiries and innovations, which began especially in the military area, they also manifested themselves with educational programs and schools centered on military regimes. This paradigm shift, which accelerated especially with the 18th century, soldier-son themed citizen perception and the current dominant patriarchal moral shave had reflections on education mentality and practice of social structure organized by the state and they turned into bringing up sons as warriors, power-owners and citizens ready to sacrifice for their motherland.ÖzBu çalışmada, Ulus-devlet anlayışının ivme kazandığı Avrupa devletlerinde vatandaş-asker anlayışı ve uygulamasının ön plana geçtiği II. Meşrutiyet yıllarında açılan paramiliter örgüt ve derneklere ilişkin çabalar mercek altına alınmıştır. Araştırma doküman incelemesine dayalı nitel bir çalışmadır. Üç kıtaya yayılan topraklarını hızla kaybetme sürecine giren Osmanlı İmparatorluğu’nda yaşanan savaş travmalarından sonra vatandaş kavramı çerçevesinde eğitim anlayışı yeniden gözen geçirilmiştir. Özellikle askeri alanda başlayan bu sorgulamalar ve yenilik arayışlarının yanı sıra, yine askeri düzenlemeleri merkeze alan eğitim programları ve okulları ile kendini açıkça belli etmiştir. Özellikle 18. Yüzyılla birlikte hız kazanan bu paradigma değişimi, asker-evlat ana temalı vatandaş algısı ile halihazırda baskın ataerkil değerler, sosyal yapının bu kez devlet eliyle organize edilen eğitim anlayışı ve uygulamalarına yansımış; “savaşçı, erk sahibi, vatana kendini feda etmeye hazır” –özellikle erkek- evlatların yetiştirilmesine dönüşmüştür.

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Musso, Maurizio, Renato Scalone, Alessandra Crescimanno, Antonio Pinto, Gianpaolo Marcacci, Nicola Cascavilla, Potito Rosario Scalzulli, et al. "Fotemustine, Etoposide, Aracytin and Melphalan (FEAM), a Different Conditioning Regimen for Lymphoma Treatment with Autologous Hemopoietic Stem-Cell Transplantation." Blood 112, no. 11 (November 16, 2008): 4456. http://dx.doi.org/10.1182/blood.v112.11.4456.4456.

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Abstract Introduction . BEAM (carmustine, etoposide, aracytin, melphalan) is a conditioning regimen used in autologous hemopoietic stem cell transplantation for Hodgkin Lymphoma and non Hodgkin Lymphoma, with acceptable toxicity and high efficacy. In our study we replaced the carmustine with fotemustine, an analogous chloroethylnitrosourea. Primary end-point was to valuate the feasibility of this modified conditioning regimen. Patients and Methods . 86 patients were consecutively conditioned in seven BM-Units with FEAM before receiving aHSCT. 44 patients (63%) were male, 32 (37%) female. Median age was 51 years (range, 18–77). 23 patients (27%) had HL, 60 (70%) had NHL (2 SLL, 1 LPL, 1 MZL, 2 FL, 6 MCL, 37 DLBCL, 3 BL, 1 B-LBL, 1 T-LBL, 4 u-PTCL, 2 AIL), 1 patient had a B-CLL, 1 a B-ALL FAB L3 and 1 an aggressive NK-cell leukemia. In the lymphoma group, 22 patients (27%) were in stage II (10 with bulky disease), 20 (24%) in stage III and 41 (49%) in stage IV. Among lymphoma patients, 19 (23%) had a bone marrow involvement, 5 (6%) a central nervous system involvement, including 2 primary central nervous system lymphoma. At the time of transplantation, 41 patients (48%) were in CR, 3 (3%) in VGPR, 32 (37%) in PR, 10 (12%) had a resistant-progressive disease (R/PD); 30 patients (35%) were at first line of therapy, 56 (65%) had received more than one line of therapy. Patients received fotemustine 150 mg/m2 on days -7, -6, etoposide 200 mg/m2 and aracytin 400 mg/m2 on day -5, -4, -3, -2, and melphalan 140 mg/m2 on day -1. The median number of CD34+ cells infused was 3.8 × 106/Kg recipient body weight (range, 1–21.8). Results . Only 2 patients were not evaluated for engraftment and toxicity. Among evaluable patients, all engrafted. The median time to neutrophil (N >0.5 × 106/L) and platelet (PLT >20 × 109/L) recovery was 11 (range, 9–19) and 13 days (range, 6–105) respectively. 55 patients (65%) received trasfusions of red blood cell units, with a median of 2 units (range, 1–8). All patients received platelet trasfusions with a median of 2 units (range, 1–15). Toxicity . No chemotherapy-induced nausea and vomiting (CINV) was observed in 17 patients (20%), 53 patients (63%) had CINV grade I–II, 14 patients (17%) grade III, no grade IV was observed. No mucositis was observed in 16 patients (19%), 45 patients (54%) had mucositis grade I–II, 17 patients (20%) grade III, 6 patients (7%) grade IV. No diarrhea was observed in 50 patients (60%), 29 patients (34%) had diarrhea grade I–II, 5 patients (6%) grade III, no grade IV was observed. No epatic toxicity was observed in 80 pts (95%), 1 patient had epatic toxicity grade I, 1 patient grade II and 2 patients grade III, no grade IV was reported. Only one patient had a transient renal toxicity grade II. No pulmonary toxicity was observed. Fever >38, 5°C was documented in 68 patients (81%) with a median duration of 4 days (range 1–25). GRAM-were identified in 15 patients, GRAM+ in 14 patients, yeasts were isolated in 3 patients and there was only one infection by Pneumocystis Carinii. In the other 35 patients (51%) no organism was identified as the source of the fever which was classified as FUO. Outcome . At a median follow-up of 5 months (range, 1–16), 79 patients (92%) are alive. On 75 evaluated patients, fifty-nine (79%) are alive and free from disease. Among the seven deceased patients, three died for PD at day +111, +110 and +75 from transplantation respectively, one died for bacterial meningitis at day +45 from transplantation, after a complete hematologic recovery, one in PR died for gastric haemmorrhage from tumor site, and two (1 CR, 1 VGPR) died for comorbidity, respectively at day +150 and +240 from transplantation. TRM at 100 days was 1%. Among the 75 patients who were evaluated after aHSCT, thirty-five patients, out of thirty-six who were in CR before aHSCT, maintained the CR after, for the other thirty-nine, twenty-seven (69%) achieved the CR (three of these had a CNS involvement before aHSCT), one achieved a VGPR, two a PR (ORR 77%), four had a stable disease and five progressed. Considering as treatment failure the relapse, the progression or the death for any cause, in our study the treatment failure was assessed on 16%. Conclusions . Our study demonstrated the feasibility and the safety of the FEAM, regard its toxicity it was not superior with respect to BEAM. However, a longer follow-up is needed to valuate the efficacy of this modified conditioning regimen in term of clinical response.

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Leeuwen, Theo van. "Mineral Exploration and Mining in Sumatra, Indonesia—A Historical Overview." SEG Discovery, no. 129 (April 1, 2022): 21–29. http://dx.doi.org/10.5382/segnews.2022-129.fea-01.

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Abstract Sumatra, Indonesia, has a long and checkered history of mineral exploration and mining that dates back to prehistoric times. These activities have been dominated by gold, involving both the local population and mostly foreign companies. The first documented mining activity was the reopening of the ancient silver-rich Salida gold mine in West Sumatra in 1669 by the VOC (Vereenigde Oost-Indische Compagnie), a Dutch trading company that for two centuries monopolized trade between Europe and Asia. The government of the Netherlands East Indies initiated geologic investigations and mineral exploration in 1850, and private industry followed 30 years later. Between 1899 and 1940, 14 gold mines were developed, most of which were short-lived and uneconomic. Total production between 1899 and 1940 was 101 t Au and 1.2 Mt Ag. During the Japanese occupation, in its aftermath, and for the first 20 years of Indonesia’s independence, there was very little activity. In 1967, introduction of new foreign investment and mining laws by the New Order government heralded a new era of exploration and mining activity that continues to the present day. Since 1967, there have been several peaks in exploration activity, viz. 1969 to 1973 (porphyry copper), 1985 to 1990 (gold), 1995 to 1999 (gold), and 2006 to 2010 (multi-commodity). A variety of previously unknown mineralization types were discovered, including porphyry Cu, high-sulfidation Au, sediment-hosted Au, and sediment-hosted Pb-Zn. Activity during the modern area has included the reopening of one of the old Dutch mines, development of four new gold discoveries including the giant Martabe district (310 t Au), and exploitation of several small Fe skarn deposits known from the Dutch time. By world standards, to this day Sumatra remains underexplored.

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Eldredge, P. A., K. S. Bose, D. E. Barber, R. F. Bryan, E. Sinn, A. Rheingold, and Bruce A. Averill. "Synthesis and structures of the [MoFe6S6(CO)16]2-, [MoFe4S3(CO)13(PEt3)]2-, and [Mo2Fe2S2(CO)12]2- ions: high-nuclearity molybdenum-iron-sulfur clusters as potential precursors to models for the FeMo-cofactor of nitrogenase. [Erratum to document cited in CA114(24):239266a]." Inorganic Chemistry 31, no. 7 (April 1992): 1310. http://dx.doi.org/10.1021/ic00033a037.

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Son, Hoang Thanh, and Truong Van Anh. "Determination of drainage corridor in the downstream Vu Gia - Han river, Da Nang city." VIETNAM JOURNAL OF EARTH SCIENCES 41, no. 1 (January 8, 2019): 46–58. http://dx.doi.org/10.15625/0866-7187/41/1/13546.

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Flood is one of the most well-known phenomena in the Central Vietnam where Da Nang city is located. As the most area in the central coastal part, this city frequently suffers to flood without any prevented structure like sea dike or river levee. The only thing that can help to the response for flood is emergency plans. Therefore, flooding still causes great damages to the economic development and social stability in this region. For ensuring the sustainable development of Da Nang city under the impacts of climate change and sea level rising, it requests a change in direction of the solution, from the flood control to the adaptation and living with floods through spatial planning to make a good condition for optimal drainage corridors. This paper suggests a design flood drainage corridors for Da Nang city that was developed by combining of mathematical model, GIS, hydro-meteorological documents of Vu Gia - Thu Bon basin from 2009 to present. These proposal solutions include (i) widening of the riverbed and providing a river corridor protection along both river banks; (ii) creating of drainage channels for the land between the rivers and (iii) creating of space for floodwater in an appropriate time. The result was so good and it helps to reduce the flood in Da Nang from 5% to 10%. Therefore this would be a scientific basis for identifying the flood drainage corridors of other river basins in the central coastal region without typical dike cover.ReferencesBruun et al., 2013 On the Frontiers of Climate and Environmental Change: Vulnerabilities and Adaptation in Central Vietnam, Springer Verlag, Berlin, Germany.CCFSC (Central Committee for Flood and Storm Control), 2005. “National Report on Disasters in Vietnam.”, the World Conference on Disaster Reduction, January 18–22, Kobe-Hyogo, Japan.Da Nang Statistical Office, 2016. Statistical Yearbook, Statistical publishing house, Hanoi.Da Nang University of Science and Technology, 2014. Project of Da Nang Hydrology and Urban Development Simulation Model supported by Rockefeller, Stored report of the Climate Change Coordination Office, Da Nang.Da Nang City Steering Board for Storm and Flood Prevention and Search and Rescue, Resume of the Flood Prevention and Search and Rescue works from 2000 to 2016, Stored report of the Office of People’s Committee of Da Nang city.Dang Thi Kim Nhung, 2016. Review of flood prevention planning in the central provinces from Quang Binh to Binh Thuan. Proceedings of the 55th anniversary of InstituteofWater Resources Planning, Hanoi.Decision No. 2357/QD-TTG dated 04 December 2013 approving the adjustment of general planning of Da Nang city by 2030 with a vision toward 2050.Decree No. 43/2015/ND-CP dated on 6 May 2015. Hanoi establishment and management of water source protection corridors.DHI Dan Mach, 2011. MIKE 11(RR+HD) - A Modelling system for rivers and channels, User guide.DHI Dan Mach, 2011. MIKE 21- Flow Model FM, User guide.Dinh Phung Bao, 2013. The study using GIS for flood prevention mapping system in Vu Gia-Thu Bon river basin, Stored report of the Mid-Central regional hydrometeorological center, Da Nang.FEMA, 1995. Managing Floodplain Development in Approximate Zone A Areas - A Guide for Obtaining and Developing Base Flood (100-year) Flood Elevations - FEMA 265.Floodway: https://www.fema.gov/floodplain-management/floodway#0.Hoang Ngoc Tuan, 2016. Comprehensive assessment of resistance of surface water resource to the climate change of the city, Stored report of Climate Change Coordination Office, Da Nang.Hoang Thai Binh, 2017. Determination of flood drainage corridor in the downstream area of Vu Gia - Thu Bon river (in Da Nang city) when the hydropower system in the upper in operation in the context of climate change. Final report of project’s code VAST-NĐP.12/15-16, Hanoi.JICA, 2009. Report Project for Building Disaster Resilient Societies in Central Regions of Vietnam.LUCCI, 2015. Study on the land use and climate change interactions in Central Vietnam, http://www.lucci-vietnam.info/vn/.Ministry of natural resources and environment, 2016. Climate change, sea level rise scenarios for Vietnam.NRWA Waterways Section And BG&E Pty LTD, 2006. Floodway Design Guide, Government of Western Australia.Nguyen Kim Loi, 2016. The support system for Flood warning (case study in Vu Gia - Thu Bon river basin, Quang Nam province), Agricultural Publishing House, Hanoi.SRV (Socialist Republic of Vietnam), 2007. National Strategy for Natural Disaster Prevention, Response and Mitigation to 2020. November 16. Hanoi, VietnamTran Tuan, Bui Dung, 2012. The.Natural Disasters in Vietnam A SYNTHESIS FROM A SOCIOECONOMIC PERSPECTIVE, 179-198.Vu Thi Thu Lan, 2011. Field survey and hydraulic modeling of Thu Bon river basin, Quang Nam province, Stored report of Steering Board for Storm and Flood Prevention of Quang Nam.Vu Thi Thu Lan, 2013. Flood prevention mapping of Vu Gia-Thu Bon river and Thach Han-Ben Hai river in scale 1/10.000. Stored report of Office for Water Resources Projects, Ministry of Agriculture & Rural Development, Hanoi.Vu Thi Thu Lan, 2013. The study of natural disasters variation (floods and droughts) in Quang Nam in the context of climate change, J. Sci. of the Earth, Hanoi, 35(1), 66-74.World Bank, 2012. Fiscal Impact of Natural Disasters in Vietnam, http://www.worldbank.org/fpd/drfip.

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Di Renzo, Nicola, Maurizio Musso, Rosanna Scimè, Giuseppe Milone, Tommasina Perrone, Clara De Risi, Domenico Pastore, et al. "Phase II Multicenter, Not Comparative, Study of Multiple Doses of NEPA (netupitant + palonosetron) in Preventing Chemotherapy-Induced Nausea and Vomiting (CINV) in Non-Hodgkin Lymphoma Patients Eligible for Autologous Hematopoietic Stem Cell Transplantation Receiving Multiple Days / High Dose Chemotherapy Regimens." Blood 134, Supplement_1 (November 13, 2019): 1974. http://dx.doi.org/10.1182/blood-2019-125071.

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Cancer chemotherapy may be associated with a high incidence of nausea and vomiting (CINV), which may occur acutely within 24 hours after the start of chemotherapy (acute phase) or in the following days (delayed phase). Despite the availability of several antiemetics, clinical findings show that control of nausea and vomiting continue to be a serious concern for hematological patients, mainly for those receiving multiple-day (MD) and high-dose (HD) chemotherapy (CT), for which no specific international recommendations have been formulated, due to the lack of a unanimous consensus between the main international guidelines. NEPA is the first antiemetic developed as an oral fixed dose combination of two drugs that are antagonists of two receptors involved in the control of nausea and vomiting: a new highly selective NK1-RA, netupitant, and a second generation 5HT3-RA, palonosetron, that simplify the antiemetic regimen allowing for a lower number of capsules and days of treatment. In clinical practice, NEPA is administered together with dexamethasone that contributes to CINV prophylaxis by its intrinsic antiemetic properties. However, dexamethasone also exhibits an important immunosuppressive activity, which could lead to several adverse events, such as increasing the risk of serious infections, especially in patients undergoing myeloablative treatment. The rational of this study was to explore the efficacy of multiple doses of NEPA given with an every-other-day regimen without dexamethasone in preventing CINV in patients with non-Hodgkin's lymphoma (NHL) eligible for autologous stem cell transplantation (ASCT) and treated with MD-HD-CT. The chemotherapy regimen (BEAM/FEAM) was administered for 6 days, NEPA was taken on day 1, 3 and 5, and nausea and vomiting were monitored up to day 15. No dexamethasone was given for antiemetic prophylaxis. The primary endpoint was the percentage of patients achieving a Complete Response (CR; no vomiting and no use of rescue medication) during the overall phase, defined as the period from day 1 (first day of chemotherapy) until 2 days after the last dose of chemotherapy. Seventy patients participated to the study. According to the adopted Fleming one-stage design, the primary endpoint of this study was achieved. Indeed, the number of complete responders for the overall phase was 60, which is greater than the predetermined cut-off of 42, representing the minimum frequency of responders for which the treatment is considered effective. In addition to the primary efficacy result, several additional endpoints were evaluated for the study period (Figure 1). The CR values were 87.1% (primary endpoint, overall phase: days 1-8), 88.6% (acute phase: days 1-6) and 98.6% (delayed phase: days 7-8), while the complete control (CR with no more than mild nausea) was 85.7% (overall phase), 88.6% (acute phase) and 95.7% (delayed phase) (Figure 1A). Moreover, the percentages of patients that did not have any emetic episodes were 88.6% (overall phase), 90% (acute phase) and 98.6% (delayed phase) and patients that did not require a rescue therapy for controlling CINV were 94.3% (overall phase), 94.3% (acute phase) and 100% (delayed phase). Daily records taken from day 1 to day 15 showed that values for all these categories were above 85% for all the days of observation (Figure 1B). Patients also documented the grade of their nausea according to the Likert scale. Moderate and severe episodes of nausea were reported by less than 10% for the overall phase and less than 5% in both acute and delayed phase and the daily values of no nausea were above 65% for each day of the treatment (Figure 1C and 1D). Indeed, the mean patient global satisfaction for the antiemetic prophylaxis for the study period was 9.13 ± 1.59 out of 10. Regarding safety, a total of 12 Treatment-Emergent Adverse Events (TEAEs) occurred in 6 (8.6%) subjects enrolled in the study. Among these, only 1 (8.3%, constipation) was evaluated as possibly related to NEPA administration. Moreover, the only two TEAEs classified as SAE (Serious Adverse Event) were two episodes of fever that have been evaluated as not-related to NEPA. Therefore, the safety profile of NEPA was confirmed also in this setting. In conclusion, our study demonstrated that multiple alternate dosing of NEPA without the addition of dexamethasone can effectively prevent nausea and vomiting in a difficult setting, such as MD/HD-CT with a good tolerability profile. Disclosures No relevant conflicts of interest to declare.

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