Дисертації з теми "Family-based approach"
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Riaz, Atif. "A set-based approach to passenger aircraft family design." Thesis, Cranfield University, 2015. http://dspace.lib.cranfield.ac.uk/handle/1826/9723.
Повний текст джерелаChoubey, Anand M. "Platform based approach for economic production of a product family." Thesis, Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/434.
Повний текст джерелаJirapanthong, Waraporn. "A rule-based approach for software traceability on product family systems." Thesis, City University London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435040.
Повний текст джерелаLum, Lai-chun, and 林麗珍. "A weight management programme for obese children: parent-only family-based approach." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43251444.
Повний текст джерелаKnight, John Andrew. "A Diels-Alder based synthetic approach to the manzamine family of alkaloids." Thesis, University of Salford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265523.
Повний текст джерелаLum, Lai-chun. "A weight management programme for obese children parent-only family-based approach /." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43251444.
Повний текст джерелаStoll, Timothy Michael. "Rethinking the House and the Family Within: A Needs-based Approach to Design." Cincinnati, Ohio : University of Cincinnati, 2009. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1250700760.
Повний текст джерелаAdvisor: Tom Bible. Title from electronic thesis title page (viewed Jan. 14, 2010). Includes abstract. Keywords: Housing. Includes bibliographic references.
Liu, Andrew. "A latent profile clustering approach to phenotype definition in family based genetic association studies." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110648.
Повний текст джерелаObjectifs: Des études d'association génétique ont démontré que les gènes affectent l'incidence du trouble déficitaire de l'attention avec ou sans hyperactivité (TDAH) chez les enfants. Cependant, la relation entre les gènes et la réponse aux médicaments (méthylphénidate) n'a pas été étudiée de façon approfondie. Les découvertes en la matière sont rares et difficiles à répliquer. L'absence de résultats pourrait s'expliquer par la difficulté de définir une mesure valide et objective pour quantifier la réponse au traitement. De plus, les méthodes statistiques conventionnelles pourraient avoir des lacunes dans le contexte des études d'association génétique. Nos objectifs sont les suivants: 1) comparer deux méthodes utilisées dans les études d'association génétique et 2) définir un phénotype pour la réponse au traitement ayant le potentiel d'améliorer la qualité des analyses génétiques.Méthodes: À partir d'une étude de famille (n = 416) avec des enfants TDAH, nous concevons une réponse à un phénotype de traitement à l'aide d'une approche de groupement fondée sur une analyse de profil latent (APL). Le phénotype APL est basé sur des données de RASS et d'accéléromètre (Actiwatch). À partir du phénotype APL et d'un autre phénotype basé sur un jugement clinique (évaluation de consensus clinique), nous procédons à une analyse d'association génétique pour chaque phénotype séparément. Aux fins de l'analyse génétique, nous utilisons à la fois un plan cas témoins (régression logistique) et un plan basé sur la famille (FBAT). Les gènes employés dans l'étude sont des gènes candidats reconnus pour leur association avec le diagnostic de TDAH, notamment le récepteur de la dopamine (DRD3, DRD4), le latrophilin (LPHN3) et le transporteur de la dopamine (DAT).Résultats: Nous avons détecté une association entre plusieurs SNPs et la réponse APL à la variable médication ainsi que l'évaluation du consensus clinique (CCR). Dans l'ensemble, le phénotype basé sur l'analyse du profil latent a surpassé le phénotype basé sur l'évaluation du consensus clinique (CCR) par sa capacité de produire des résultats très significatifs (p = 0,000189 contre p = 0,026691). L'approche d'analyse FBAT, malgré son insensibilité à la stratification de la population, n'était pas aussi puissante que la méthode de régression logistique, en raison de la taille restreinte des échantillons, expliquée par des parents hétérozygotes non-informatifs.Discussion: Notre analyse a démontré que la façon dont le phénotype est défini affecte sérieusement la qualité de l'analyse. Le phénotype que nous avons conçu a offert un meilleur rendement probablement en raison de sa capacité à distinguer des groupes hétérogènes de sujets. Les deux méthodes d'analyse génétique ont leurs défauts: il est donc conseillé de les utiliser conjointement dans une étude d'association génétique. Les lacunes de cette étude comprennent entre autres la taille limitée de l'échantillon, qui a limité la puissance et empêché le recours à d'autres méthodes telle l'analyse des haplotypes.
Di, Cola Simone. "A component-based approach to modelling software product families with explicit variation points." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/a-componentbased-approach-to-modelling-software-product-families-with-explicit-variation-points(b649eda2-8cac-46a5-888e-ee0926080ecb).html.
Повний текст джерелаYang, Tun-Hsiang. "Family based liquid association study an approach to map the disease genes for the complex trait /." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1610653951&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Повний текст джерелаSoberon, Sophia Elena. "Integrating a Neighborhood Approach in a Community-based Organization| A Case Study of the Cambodian Family." Thesis, California State University, Long Beach, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10839719.
Повний текст джерелаCommunity-based organizations (CBOs) represent an important segment of public services vital to the stability of invisible communities that otherwise remain vulnerable. Drawing from over three years of ethnographic fieldwork in a CBO in Santa Ana, California, I undertake an extensive case-study that examines their survival in a hostile funding environment by means of understanding their development, organizational learning and adaptation, social capital and networking and use of innovative sustainability strategies. The struggles this CBO encountered in their pursuit of sustainability speak to their unique aspects of service provision and community development making them an indispensable support structure for low-income immigrant and refugee communities.
I argue that their story of success reveals key principles, tenets and preliminary takeaways that may be useful toward improving the sustainability of organizational frameworks within other CBOs. Additionally, I explore how this CBO struggles to defend its vision of social change against existing conditions within the market environment that impact their success.
With growing interest toward scholarly work in this field, I emphasize the need to approach organizational fieldwork analytically as we engage with and try to understand the complicated social worlds of CBOs. The applied portion of this project resulted in the creation of promotional materials that may be useful toward fund development and historical preservation.
Lovejoy, Kimberly Ann Rose. "Marriage moments : an evaluation of an approach to stregnthen couples' relationships during the transition to parenthood, in the context of a home visitation program /." Diss., CLICK HERE for online access, 2004. http://contentdm.lib.byu.edu/ETD/image/etd533.pdf.
Повний текст джерелаFritz, Lorell C. "School-based family resource centres : the village approach, a handbook on school-community partnerships for professionals serving families /." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ63978.pdf.
Повний текст джерелаGoff, Rachel. "It takes a village to raise a family : designing desire-based community support with parents receiving a family service in south-west Ballarat." Thesis, Federation University Australia, 2021. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/180628.
Повний текст джерелаDoctor of Philosophy
Chamberlain, Matthew Kipp. "An Approach to Decision Support for Strategic Redesign." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/19838.
Повний текст джерелаLim, Hye-Young. "Legally recognising child-headed households through a rights-based approach : the case of South Africa." Thesis, University of Pretoria, 2009. http://hdl.handle.net/2263/25615.
Повний текст джерелаThesis (LLD)--University of Pretoria, 2009.
Centre for Human Rights
unrestricted
Vilches, Silvia L., Beth S. McDaniel, Haley Sherman, Brianna Burks, Allie Merritt, Terra Jackson, and Synithia W. Flowers. "Engaging with a Prevention Approach: System Supports Needed in Child Abuse and Neglect Prevention." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/secfr-conf/2020/schedule/13.
Повний текст джерелаErickson, Amy Teresa. ""160°F for your family" an emotions-based approach to motivating women in WIC to use a food thermometer in ground beef patties /." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Fall2009/a_erickson_112309.pdf.
Повний текст джерелаTitle from PDF title page (viewed on Jan. 8, 2010). "College of Pharmacy." Includes bibliographical references (p. 93-101).
Manca, A. "CHARACTERIZATION OF CAMELINA SATIVA GENOME, AN OILSEED PLANT, THROUGH A COMBINED APPROACH BASED ON THE Β-TUBULIN GENE FAMILY AND MICROSATELLITE MOLECULAR MARKERS". Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/168717.
Повний текст джерелаJackson, Michelle B. "Addressing mental health needs on college campuses| Utilizing recovery principles that encourage a holistic approach, selfresponsibility, strengths-based practice, cultural sensitivity, and family support." Thesis, Pepperdine University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10038735.
Повний текст джерелаResearch shows that there has been a significant increase in mental health issues within the college student population. Applying recovery-oriented principles as defined by the Substance Abuse and Mental Health Services Administration (SAMHSA) may be an effective approach to creating and adapting mental health resources for college students. In the current study, literature on the following was reviewed: (a) the college culture, (b) the prevalence of mental health issues for college students, and (c) recovery-oriented principles. Then, a critical analysis of the literature was conducted based upon the following recovery-oriented principles: (a) encouraging a holistic approach, (b) self-responsibility and self-empowerment, (c) strengths-based practice, (d) cultural sensitivity), and (e) family support. Findings indicate that holistic resources highlight individual needs and creativity; programs that encourage self-responsibility underscore the importance of self-screenings; strengths-based approaches are centered around building self-esteem and increasing positive emotions; culturally sensitive resources are often group-oriented and acknowledge multiple facets of diversity, and programming that promotes family support emphasizes psychoeducation and stigma reduction. Based upon the integration of these findings, adaptations of current efforts on campus to promote these principles, as well as new ideas, are provided.
Gzara, Chaïma. "Génétique humaine de la lèpre au Vietnam : une histoire de familles." Electronic Thesis or Diss., Université Paris Cité, 2021. http://www.theses.fr/2021UNIP5234.
Повний текст джерелаLeprosy is a chronic infectious disease caused by Mycobacterium leprae. It primarily affects the skin and peripheral nerves, and can cause an irreversible impairment of nerve function, often leading to severe disabilities and social stigma if left untreated. The disease, re-qualified by WHO (World Health Organization) as a “Neglected Tropical Disease” in 2017, remains a major public health problem in regions of endemic countries, with over 200,000 new cases per year (one every two minutes). It is ranked second as the most common mycobacterial infectious disease, right after tuberculosis. While it has been well established that there is a genetic contribution to this disease, the underlying genetic causes remains unknown. In our study, we sought to reveal the host´s genetic architecture of leprosy by taking of a familial epidemiological approach. We conducted the first Family-Based Genome-Wide Association Study (GWAS) of leprosy in 481 Vietnamese nuclear families (parents and children) selected based on one affected child and collected over the past 20 years. Using this sample of 1,749 individuals, including 622 affected offspring, we performed association tests between six million biallelic genetic variants (Single-Nucleotide Polymorphism, genotyped or imputed) and the binary phenotype of disease status. Following this first analysis, we conducted a replication analysis of the most promising results in an independent sample of the same ethnic origin, accounting for 1,181 cases and 668 controls. The most significant results were observed within the HLA (Human Leukocyte Antigen) region, in which 3 independent SNPs displayed genome-wide significant associations. Among these, two were for the HLA class I region and one for the HLA class II (rs1265048 [OR = 0.69; p-value = 5.5x10⁻¹¹], rs114598080 [OR = 1.47; p-value = 8.8x10⁻¹³] and rs3187964 [OR = 1.67; p-value = 8.4x10⁻¹⁶] respectively). We also identified a missense variant in the LACC1 gene (rs3764147: OR = 1.52; p-value = 5.1x10⁻¹⁴) and an intergenic variant located close to the IL12B gene (rs6871626: OR = 0.73; p-value = 6.4x10⁻⁸). LACC1 encodes a central regulator of the metabolic function and bioenergetic state of macrophages and IL12B encodes IL-12p40, which is common to two interleukins, IL-12 and IL-23. Large GWAS are expensive, strongly limiting the number of variants to test in a replication set. Here, we took advantage of the available parental phenotypic and genotypic information to perform a classical case-control study among the parents of the family-based sample. Indeed, using of extensive computer simulations, we demonstrated that this population-based parental study is a valid, powerful and costless replication strategy to confirm family-based associations. Overall, our observations add to the attractiveness of family-based designs and should provide valuable help for investigators planning to perform GWA studies. Understanding leprosy pathophysiology infection is crucial to optimize preventive approaches based on genetic profiles. Dissection of the genetic control of the infection by M. leprae by its human host, therefore, constitutes an indispensable step. Finally, repositioning the family at the heart of the genetic quest means repositioning genetics into its natural environment
Love, Beverly. "The cycle of relapse and recovery of substance misusing offenders on a community based rehabilitation programme : the impact of childhoods, family, relationships, significant life events and psychological wellbeing : an interpretative phenomenological analysis and approach." Thesis, University of Surrey, 2018. http://epubs.surrey.ac.uk/845638/.
Повний текст джерелаEbersohn, Suzette. "Die benutting van veerkrag deur middel-adolessente in ’n hersaamgestelde gesin." Thesis, University of Pretoria, 2011. http://hdl.handle.net/2263/24197.
Повний текст джерелаThesis (PhD)--University of Pretoria, 2011.
Educational Psychology
unrestricted
Erzurumluoglu, Abdullah Mesut. "Population and family based studies of consanguinity : genetic and computational approaches." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.691165.
Повний текст джерелаManilich, Elena A. "Hereditary Colorectal Cancer: Information-Based Approach." Cleveland, Ohio : Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1252247671.
Повний текст джерелаTitle from PDF (viewed on 2009-12-30) Department of Electrical Engineering and Computer Science Includes abstract Includes bibliographical references and appendices Available online via the OhioLINK ETD Center
Thomas-Chollier, Morgane. "Evolutionary study of the Hox gene family with matrix-based bioinformatics approaches." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210457.
Повний текст джерелаAs transcription factors, Hox proteins regulate target genes by specifically binding DNA on cis-regulatory elements. Only a few of these target genes have been identified so far. The second goal of this work was to evaluate whether it is possible to apply computational approaches to detect Hox cis-regulatory elements in genomic sequences. Regulatory Sequence Analysis Tools (RSAT) is a suite of bioinformatics tools dedicated to the detection of cis-regulatory elements in genomes. We participated to the development of matrix-based pattern matching approaches in RSAT. After having performed a statistical validation of the pattern-matching scores, we focused on a study case based on the vertebrate HoxB1 protein, which binds DNA with its cofactors Pbx and Meis. This study aimed at predicting combinations of cis-regulatory elements for these three transcription factors.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Yang, Jingyuan. "Likelihood Approaches for Detecting Imprinting and Maternal Effects in Family-Based Association Studies." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1275426657.
Повний текст джерелаSauerheber, Jill Duba, and J. Graham Disque. "A Trauma-Based Physiological Approach: Helping Betrayed Partners Heal from Marital Infidelity." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/2790.
Повний текст джерелаOloyede, Tobi F. "The Resilience of Female Survivors of Intimate Partner Violence in Southwest Nigeria: An Interdisciplinary Analysis." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3814.
Повний текст джерелаLusito, E. "A Network-based Approach to Breast Cancer Systems Medicine." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/265572.
Повний текст джерелаEbersohn, Suzette. "Die verhouding van die vader in 'n hersaamgestelde gesin met sy nie-inwonende kind." Diss., Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-10022007-100056/.
Повний текст джерелаProsser, Rina Marie. "Laying the Foundation for New Approaches in Evidence-Based Sex Education Curriculum Programs: A Family Life Policy Change." ScholarWorks, 2015. https://scholarworks.waldenu.edu/dissertations/1208.
Повний текст джерелаSantana, Sondra Michelle Phipps. "Practitioners' Use of Clinical Practice Guidelines: An Evidence-Based Approach." UNF Digital Commons, 2013. http://digitalcommons.unf.edu/etd/462.
Повний текст джерелаLee, Claire Elizabeth. "Applying psychological theory to understand the difficulties and supporting factors in implementing family based approaches in alcohol treatment services." Thesis, University of Leicester, 2009. http://hdl.handle.net/2381/31256.
Повний текст джерелаSoler, Garcia Jordi. "Towards disentangling the genetic complexity and clinical heterogeneity of psychotic disorders: from family-based approaches to gene-environment studies." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/674023.
Повний текст джерелаEls trastorns psicòtics són trastorns mentals amb una prevalença mundial del 4% i amb una gran càrrega personal, econòmica i social associada, que estan causats per factors genètics, factors ambientals i la interacció d’ambdós durant diferents etapes del desenvolupament cerebral. Si volem disposar de noves teràpies que ajudin a millorar la qualitat de vida de les persones amb algun diagnòstic psicòtic, és evident que abans ens cal entendre millor les contribucions que la càrrega genètica i la càrrega ambiental de cada individu tenen en el desenvolupament d’aquests trastorns. Malauradament, l’estudi de les bases etiològiques de l’esquizofrènia i d’altres trastorns psicòtics està condicionada per la gran heterogeneïtat clínica que presenten aquests fenotips. Per tant, per tal de seguir avançant en la identificació dels factors genètics associats al risc per a psicosi, és necessari conèixer i abordar els factors relacionats amb aquesta heterogeneïtat. En aquest sentit, aquesta tesi pretén contribuir a abordar aquesta heterogeneïtat intrínseca als trastorns psicòtics a través de diferents estratègies: l’ús de mostres de famílies, l’ús de fenotips intermedis associats al risc per a psicosi i l’estudi de la interacció gen-ambient en l’etiologia d’aquests trastorns. En aquesta tesi s’han plantejat tres hipòtesis diferents, que han donat lloc a 6 articles publicats en revistes científiques internacionals. Els resultats inclosos en la tesi revelen que l’anàlisi de fenotips intermedis associats al risc per psicosi en mostres de famílies facilita la identificació de formes més homogènies de psicosi, en relació a la seva etiologia genètica. Així doncs, mitjançant aquesta estratègia s’han identificat dos fenotips subclínics, com són la esquizotípia (trets de personalitat) i la dimensió cognitiva de l’atenció i la memòria de treball, com a marcadors de vulnerabilitat familiar per a psicosi en una mostra de famílies afectades amb esquizofrènia i en una de famílies afectades amb trastorn bipolar, respectivament. L’estudi del patró d’agregació familiar d’aquests fenotips ha permès la identificació de subgrups de famílies amb perfils fenotípics –i, per tant, també genotípics– similars. A més, en mostres clíniques i també no-clíniques, s’ha identificat la relació d’alguns gens relacionats amb la plasticitat sinàptica (DAOA, ZNF804A, AKT1) amb el risc de patir psicosi, mesurat a través de l’expressió de diferents fenotips intermedis com els nivells d’esquizotípia o el rendiment cognitiu. Els resultats inclosos en aquesta tesi també evidencien el paper que la variabilitat genètica té sobre el rendiment cognitiu i, alhora, com a modulador de l’efecte que el consum de cannabis té sobre l’expressió de diferents fenotips intermedis. En particular, s’ha descrit l’efecte del gent AKT1 en l’atenció i també l’efecte del gen ZNF804A sobre l’expressió de l’esquizotípia condicionat al consum de cannabis. Tot i els últims avenços en la comprensió de la etiologia de la psicosi, la investigació dels factors genètics causants de la psicosi i la seva interacció amb els factors ambientals encara té un llarg camí per recórrer. Aquesta tesi ha pretès aportar un granet de sorra a la construcció col·lectiva d’aquest coneixement mitjançant l’ús de diferents estratègies, les quals han demostrat que poden ser molt útils per tal d’abordar d’una manera més eficaç l’heterogeneïtat clínica inherent als trastorns psicòtics i poder millorar la identificació de les variants genètiques i ambientals implicades.
Calderon, Kristen Naylor. "The impact of cross-cultural transition on intercultural relationships using a strengths-based approach." Scholarly Commons, 2012. https://scholarlycommons.pacific.edu/uop_etds/825.
Повний текст джерелаCostantino, Félicie. "Recherche de nouveaux facteurs génétiques de susceptibilité à la spondyloarthrite grâce à une approche associant études familiales et génomique fonctionnelle." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T056/document.
Повний текст джерелаSpondyloarthritis (SpA) is a frequent and disabling chronic rheumatic disease. To date, more than 20 susceptibility loci have been identified, including HLA-B27 in the major histocompatibility complex (MHC). Most of the disease heritability remains to be elucidated. The aim of the study was to identify new genetic factors of susceptibility to SpA using an approach combining genetics and functional genomics. In the first part of this work, we genotyped SpA multiplex families with microarrays of 250,000 SNPs. Non parametric linkage analysis revealed a new locus significantly linked to SpA outside the MHC, in 13q13. Further studies on this locus allowed us to map the disease interval to a 1.3 Mb region, which will be soon sequenced. Moreover, family-based association study identified a significant association between one intronic SNP in MAPK14 and SpA. We also showed that one of the known ankylosing spondylitis-associated SNP in IL23R was indeed associated with sacroiliitis in SpA. We have also compared dendritic cells gene expression between nine SpA patients and ten controls and identified 81 genes differentially expressed. Moreover, we showed that ERAP1 gene expression (and at a less extent protein expression and enzymatic activity) is under the control of several polymorphisms in the gene which has previously been associated with SpA
Dashora, Pushpanjali. "Empowering Homeless Youth: An Evaluation of a Participatory Action Research Based Program." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1267458035.
Повний текст джерелаJonsson, Louise, and Matilda Nilsson. "Should sex tourism be viewed as a threat for future development? : A perspective that explores the general approach of sex tourism and prostitution in the tourism industry based on historical, cultural, and traditional values in The Gambia." Thesis, Högskolan i Halmstad, Akademin för lärande, humaniora och samhälle, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-31521.
Повний текст джерелаChen, M. "Uncovering genetic risk factors in multiple sclerosis using a family-based approach." Thesis, 2022. https://eprints.utas.edu.au/47556/1/Chen_whole_thesis.pdf.
Повний текст джерелаLinton, Brittany Anne. "A strength based approach examining resiliency in college students from single-parent family structures." Thesis, 2013. http://hdl.handle.net/2152/24341.
Повний текст джерелаtext
Brodovsky, William. "Opening the lens : the treatment of families with adolescents : a structurally based solution focused family therapy approach." 1991. http://hdl.handle.net/1993/22476.
Повний текст джерелаYang, Jinn-Moon, and 楊進木. "A Family Competition Evolutionary Approach of Global Optimization in Neural Networks, Optical Thin-film Design, and Structure-based Drug Design." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/68033929919617906217.
Повний текст джерела國立臺灣大學
資訊工程學研究所
89
Global optimization problems arise in many practical applications, such as engineering, natural sciences, economics, bioinformatics, and business. In this dissertation, a new evolutionary algorithm, called family competition evolutionary approach (FCEA), is proposed not only as the answer to global optimization, but also to be used for several practical applications. Based on family competition and adaptive rules, the proposed approach consists of global and local strategies by integrating decreasing-based mutations and self-adaptive mutations. These smoothly integrated strategies enable FCEA to balance the exploration and exploitation to achieve robust performance for global optimization. FCEA is then applied to certain areas of global optimization such as the function optimization and general constrained optimization problems. The experiments show that the proposed approach is more robust than other comparative evolutionary algorithms, including genetic algorithms, evolution strategies, and evolutionary programming FCEA has produced promising results in a number of applications, including training neural networks, optical thin-film coatings, and flexible ligand docking. For neural networks, FCEA is able to train feedforward neural networks for classification benchmarks, such as two-spiral problem and sonar classification. FCEA also gives promising recurrent neural networks for artificial intelligence problems, such as artificial ant problems and regular language recognition. FCEA is a good synthesis answer for the most important thin-film designs, including antireflection coatings, beam splitter, narrowband filters, and edge filters. Optical thin-film coatings have numerous remarkable applications in many branches of science and technology, such as scientific instrument manufacturing, spectroscope, medicine, and astronomy. Finally, it is verified that FCEA is able to generate low-energy solutions for flexible ligand docking problems, the molecular recognition between two molecules, which are are important for structure-based drug design With the encouraging results shown, FCEA can imply certain characteristics. This thesis has also analyzed the global convergence property, search behaviors, and the parameter setting of FCEA. We believe that the flexibility and robustness of FCEA make it an effective tool for global optimization problems.
Prevost, Brittany. "The LNX Family of Multi-PDZ E3 Ligases: Using a Mutagenesis-based Approach to Establish the Role of PDZ Domains in LNX1 Function." Thesis, 2013. http://hdl.handle.net/1807/35136.
Повний текст джерелаStylianou, Nitsa. "Towards the training of psychology tutors : an ecosystemic approach." Thesis, 2000. http://hdl.handle.net/10500/16147.
Повний текст джерелаCurriculum and Instructional Studies
D.Litt. et Phil. (Psychology)
Moss, Susara Maria. "Exploring family resilience amongst South African social work client families." Diss., 2010. http://hdl.handle.net/10500/3405.
Повний текст джерелаSocial Science
M.A. (Social Work)
Georg, Simone Elyse. "Karriyikarmerren rowk – everyone working together: Towards an intercultural approach to community safety in Gunbalanya, West Arnhem Land." Phd thesis, 2018. http://hdl.handle.net/1885/160664.
Повний текст джерелаOruche, Ukamaka Marian. "Predicting Treatment Response of Adolescents with Serious Emotional Disturbance." Thesis, 2012. http://hdl.handle.net/1805/2770.
Повний текст джерелаSerious emotional disturbance, including disruptive disorders (i.e., attention deficit hyperactivity disorder, oppositional defiant disorder, and conduct disorder), affects large numbers of adolescents, with costly and tragic consequences. Adolescents with disruptive disorders are likely to be arrested, drop out of school, and have poor treatment outcomes. There is an urgent need to identify strengths-based factors associated with improvement in adolescents’ behavioral and social functioning to help them achieve their full potential. The purpose of this study was to determine whether change in adolescent personal strengths and change in family functioning over 12 months predicted changes in behavioral and social functioning for adolescents with disruptive disorders who participated in a System of Care (SOC) program and if findings varied by race. De-identified data from 179 adolescents, aged 12-17 years, with disruptive disorders and their caregivers were included in this secondary analysis. Data were analyzed using Pearson correlations, t-tests, chi-square tests, and multivariate multiple regressions. Upon admission to the program, caregiver ratings indicated that African American adolescents had greater personal strengths (p = .001), fewer behavior problems (p < .001), and less functional impairment (p < .001) compared to their Caucasian counterparts. Girls had more behavior problems (p = .05) and fewer personal strengths than boys (p < .001). Increase in caregiver-rated adolescent personal strengths was significantly associated with improvement in caregiver-rated adolescent behavioral and social functioning (p < .001). Change in caregiver-rated family functioning was not significantly associated with change in caregiver-rated adolescent behavioral and social functioning (p = .171). The strength and direction of predictors did not vary by race. The adolescents in the study participated in a SOC program that emphasized their strengths versus, primarily, focusing on their deficits. Change in caregiver ratings of adolescent personal strengths was a significant predictor of change in adolescent behavioral and social functioning over a 12 months period. Findings provide evidence for psychiatric mental health professionals to focus on enhancing adolescent personal strengths to improve behavioral and social functioning in adolescents with disruptive disorders. Future research is needed to understand the impact of family variables on adolescents’ treatment outcomes.
Aradas, Ana Carolina Martins dos Santos de Carvalho. "Abordagem baseada nas rotinas: perceção dos terapeutas da fala." Master's thesis, 2019. http://hdl.handle.net/10284/7708.
Повний текст джерелаThe Routine-Based intervention is advocated in early intervention, as it values children's routines in natural settings and with caregivers of greater affection and, Family-Centered Practices are also a pillar of this Approach. In this investigation we sought to listen to the Portuguese speech-language therapists (SLT) about the routine-based intervention, gathering their perception about it and asking if they use it in their professional practice. In order to implement these objectives, 5 questions were asked involving the degrees of importance and frequency in the SLTs´ work experience, as well as the facilitating factors and barrier to the implementation, and if there are advantages and disadvantages in this type of intervention. These therapists were also asked what strategies they considered relevant to the implementation of this approach. To obtain answers, a quantitative study was developed using a online questionnaire, where all ethical questions were safeguarded, not forgetting the anonymity of the participants and the confidentiality of the information collected. Data were collected between November and December of last year, 55 Speech-language Therapists answered the questionnaire. Statistical analysis was done through the Statistical Package for the Social Sciences, and content analysis for descriptive answers. After these two reviews - quantitative and qualitative - we can conclude that the Therapists consider the Routine-based intervention very important, although they have some difficulty in performing it on a regular basis in their professional practice. We also found some facilitating factors and barrier factors, which may justify the difficulties experienced in its implementation. Finally, advantages and disadvantages were found, as well as some strategies recognized and implemented by Speech-language therapist in this Approach.
Van, Rensburg Madri Stephani Jansen. "From victim to victory: the experiences of abused women and the salience of the support they encounter." Thesis, 2004. http://hdl.handle.net/10500/2048.
Повний текст джерелаPsychology
D. Phil. (Psychology)