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Статті в журналах з теми "Facile Michael Addition Reaction"

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Автор: Grafiati

Опубліковано: 6 вересня 2023

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1

Reddy, S. Madhava, and H. M. Walborsky. "A facile intramolecular Michael addition reaction." Journal of Organic Chemistry 51, no. 13 (June 1986): 2605–7. http://dx.doi.org/10.1021/jo00363a042.

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2

Stepanova, Ekaterina, Andrey Maslivets, Svetlana Kasatkina, and Maksim Dmitriev. "Diversity-Oriented Synthesis via Catalyst-Free Addition of Ketones to [e]-Fused 1H-Pyrrole-2,3-diones." Synthesis 50, no. 24 (August 20, 2018): 4897–904. http://dx.doi.org/10.1055/s-0037-1610647.

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Анотація:

A facile synthetic approach towards two distinct pyrrole-based heterocyclic scaffolds has been developed by the interaction of 1H-pyrrole-2,3-diones fused at the [e]-side to a 1,4-benzoxazin-2-one or quinoxalin-2(1H)-one moiety with ketones. The described interaction proceeds either as an aldol reaction or as a Michael addition/intramolecular cyclization depending on the reaction conditions. The disclosed aldol reaction proceeds with good diastereoselectivity under catalyst-free conditions when the reaction is carried out in aromatic hydrocarbons. Products of the cascade Michael addition/intramolecular cyclization reaction are predominantly formed under catalyst-free and solvent-free conditions. The proposed strategy provides facile access to pharmaceutically interesting pyrrole-based polyheterocycles.

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3

Wang, Yi-Fan, Cheng-Yu He, Longlei Hou, Ping Tian, Guo-Qiang Lin та Xiaofeng Tong. "Facile Access to 1,5-Benzodiazepines via Amine-Promoted (4+3) Annulations of δ-Acetoxy Allenoates with o-Diaminobenzenes under Mild Conditions". Synlett 29, № 09 (23 березня 2018): 1176–80. http://dx.doi.org/10.1055/s-0037-1609347.

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Анотація:

An amine-promoted (4+3) annulation of δ-acetoxy allenoate with o-diaminobenzene is reported, providing a facile access to 1,5-benzodiazepine. This method features wide reaction scope, mild conditions, and readily available starting materials. The cascade reaction involves aza-Michael addition of o-diaminobenzene to allenoate, elimination of acetate group, and subsequent 1,6-aza-Michael addition.

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4

Yang, Jingya, Tianyuan Li, Hongyan Zhou, Nana Li, Dongtai Xie, and Zheng Li. "Potassium Hydroxide Catalysed Intermolecular Aza-Michael Addition of 3-Cyanoindole to Aromatic Enones." Synlett 28, no. 10 (February 28, 2017): 1227–31. http://dx.doi.org/10.1055/s-0036-1588152.

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Анотація:

Indole is one of the utmost important heterocycles as it is an essential nucleus of many pharmaceutical compounds. Its aza-Michael reaction, however, is underdeveloped because of the moiety’s inherent characteristics. Here, a potassium hydroxide catalysed intermolecular aza-Michael reaction of 3-cyanoindole with aromatic enones is described. A variety of chalcone derivatives are well tolerated and afford the corresponding N-adducts in moderate to high yields. The use of a cheap catalyst, low catalyst loading, mild reaction temperature, and good substrate tolerance make this procedure a direct and facile method for the preparation of N1-functionalized indoles.

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5

Terent'ev, Alexander O., Vera A. Vil', Ivan A. Yaremenko, Oleg V. Bityukov, Dmitri O. Levitsky, Vladimir V. Chernyshev, Gennady I. Nikishin та Fabrice Fleury. "Preparation of a microsized cerium chloride-based catalyst and its application in the Michael addition of β-diketones to vinyl ketones". New J. Chem. 38, № 4 (2014): 1493–502. http://dx.doi.org/10.1039/c3nj01454a.

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6

Boruah, Romesh C., Anil Saikia, Apurba Chetia, and Utpal Bora. "A Facile Synthesis of 1,6-Diketonesvia a Three-Component Michael Addition Reaction." Synlett, no. 10 (2003): 1506–8. http://dx.doi.org/10.1055/s-2003-40821.

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7

Rulev, Alexander Yu, Alexey R. Romanov, Alexander V. Popov, Evgeniy V. Kondrashov, and Sergey V. Zinchenko. "Reaction of Bromoenones with Amidines: A Simple Catalyst-Free Approach to Trifluoromethylated Pyrimidines." Synthesis 52, no. 10 (March 9, 2020): 1512–22. http://dx.doi.org/10.1055/s-0040-1707969.

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Анотація:

A facile one-pot synthesis of trifluoromethylated pyrimidines has been achieved by the treatment of fluorinated 2-bromoenones with aryl- and alkylamidines. The assembly of pyrimidine core proceeds by the cascade reactions via aza-Michael addition–intramolecular cyclization–dehydrohalogenation/dehydration sequence. This strategy is featured by high selectivity and mild reaction conditions giving the target heterocycles in high yields (up to 99%). The unique influence of trifluoromethyl group on the reaction path is demonstrated.

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8

Lin, Ning, Qiu-Xiang Wei, Li-Hua Jiang, Yan-Qiu Deng, Zhen-Wei Zhang, and Qing Chen. "Asymmetric Michael Addition of Malononitrile with Chalcones via Rosin-Derived Bifunctional Squaramide." Catalysts 10, no. 1 (December 20, 2019): 14. http://dx.doi.org/10.3390/catal10010014.

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Анотація:

A rosin-derived bifunctional squaramide catalyzed asymmetric Michael addition of malononitrile with chalcones was discovered. This protocol provides a methodology for the facile synthesis of chiral γ-cyano carbonyl compounds in high yields and enantioselectivities (up to 99% yield and 90% ee) with a lower catalyst loading (0.3 mol%). The predominant R-configured adducts were obtained by this organocatalystic reaction, according to the experimental findings.

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9

Guy Taylor, Jason, Wellington Martins Ventura, and Luiz Guilherme Souza de Assis. "Facile Synthesis of Indolines by a Tandem Nitro-reduction Aza Michael Addition Reaction." HETEROCYCLES 87, no. 10 (2013): 2023. http://dx.doi.org/10.3987/com-13-12789.

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10

Fustero, Santos, Javier Moscardó, María Sánchez-Roselló, Elsa Rodríguez, and Pablo Barrio. "Tandem Nucleophilic Addition−Intramolecular Aza-Michael Reaction: Facile Synthesis of Chiral Fluorinated Isoindolines." Organic Letters 12, no. 23 (December 3, 2010): 5494–97. http://dx.doi.org/10.1021/ol102341n.

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11

Guo, Shengmei, Kun Jie, Ling Huang, Zhebin Zhang, Yufeng Wang, Zhengjiang Fu, and Hu Cai. "Fe-Catalyzed Bisphosphorylation of Amino-2-en-1-ones with Trialkyl Phosphites." Synlett 30, no. 09 (April 18, 2019): 1090–94. http://dx.doi.org/10.1055/s-0037-1611803.

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Анотація:

A facile bisphosphorylation of amino-2-en-1-ones with trialkyl phosphites mediated by iron is developed. The reaction is considered to go through two Michael addition progresses. A variety of amino-2-en-1-ones are bisphosphorylated in high yields with functional group tolerance. In addition, the protocol of introduction of two different phosphates into one molecule is successful through a cascade reaction.

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12

Cui, Dong-Xiao, Yue-Dan Li, Jun-Chao Zhu, Yan-Yan Jia, Ai-Dong Wen, and Ping-An Wang. "Highly Efficient Michael Reactions of Nitroolefins by Grinding Means." Current Organic Synthesis 16, no. 3 (June 17, 2019): 449–57. http://dx.doi.org/10.2174/1570179416666190101122150.

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Анотація:

Aim and Objective: The direct β-functionalization of trans-β-nitroolefins by Michael reaction is regarded as an efficient way to provide precursors for β-functional amines. However, Michael additions by grinding means with solvent-free conditons are rarely reported. We have developed facile access to β-functional nitroalkanes by grinding means under solvent-free conditions. Materials and Methods: From commercially available materials including ethyl 2-nitroacetate, alkyl 2-cyanoacetates and malononitrile, the grinding reactions between these above-mentioned activated methylenecompounds and various trans-β-nitroolefins were performed at room temperature and solvent-free conditions. Results: A highly efficient direct Michael reaction of nitroolefins by simple grinding means has been developed. Various trans-nitrostyrenes were easily converted into corresponding β-functional nitroalkanes in excellent yields within 5~10 min (up to 36 examples). Conclusion: Herein, we have developed a simple and efficient way to β-functional nitroalkanes through Michael reactions by grinding means. The grinding Michael reaction is fast, clean and stable and these Michael adducts could be easily converted into the other amino compounds served as building blocks in organic synthesis.

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13

An, Litao, Xiaojun Sun, Meng Lv, Jianfeng Zhou, Fengxia Zhu, and Hui Zhong. "Metal-free oxidative coupling of aminopyridines with nitroolefins to imidazo[1,2-a]pyridine in the presence of I2–TBHP–pyridine." Zeitschrift für Naturforschung B 71, no. 2 (February 1, 2016): 141–47. http://dx.doi.org/10.1515/znb-2015-0171.

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Анотація:

AbstractA facile metal-free approach to the synthesis of imidazo[1,2-a]pyridine was developed through a tandem reaction of Michael addition and oxidative coupling. Iodine–t-butyl hydroperoxide–pyridine was found to be a green and efficient catalytic system for this approach.

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14

Du, Yuqun, Hongxia Yan, Song Niu, Lihua Bai, and Fu Chai. "Facile one-pot synthesis of novel water-soluble fluorescent hyperbranched poly(amino esters)." RSC Advances 6, no. 91 (2016): 88030–37. http://dx.doi.org/10.1039/c6ra19062f.

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Анотація:

Two kinds of water-soluble fluorescent hyperbranched poly(amino esters) were first synthesized by a convenient one-pot approach via the A₂ + B₃ Michael addition reaction of trimethylolpropane triacrylate and aliphatic diamines.

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15

Yang, Guang, Wei Long, Wenfeng Yan, Hongye Huang, Meiying Liu, Hui Ouyang, Yulin Feng, Liangji Liu, Xiaoyong Zhang, and Yen Wei. "Surface PEGylation of nanodiamond through a facile Michael addition reaction for intracellular drug delivery." Journal of Drug Delivery Science and Technology 57 (June 2020): 101644. http://dx.doi.org/10.1016/j.jddst.2020.101644.

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16

Chen, Bo, and Shengming Ma. "Tandem Michael Addition/Cyclization Reaction of 2,3-Allenoates with Organozincs: Facile Synthesis of Isocoumarins." Organic Letters 15, no. 15 (July 22, 2013): 3884–87. http://dx.doi.org/10.1021/ol401625t.

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17

Ahmed, Naseem, and Iram Parveen. "A Route to Highly Functionalized Stereospecific trans-Aminated Aurones from 3-Bromoflavones with Aniline and N-Phenylurea via a Domino Aza-Michael Ring Opening and Cyclization Reactions." Synthesis 51, no. 04 (October 10, 2018): 960–70. http://dx.doi.org/10.1055/s-0037-1610662.

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Анотація:

A facile cascade reaction is reported via aza-Michael addition, ring opening, and cyclization between 3-bromoflavone and aniline derivatives or N-phenylurea in the presence of KOt-Bu and CuI in DMF under mild reaction conditions. Products were obtained as stereospecific trans-aminated aurones in good to excellent yields (61–83%). Our protocol is operationally successful with ease, avoids the requirement of additives and ligands, and offers broad substrate scope.

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18

Liao, Jia-Yu, Wei Jie Yap, Ji'En Wu, Ming Wah Wong, and Yu Zhao. "Three-component reactions of isocyanoacetates, amines and 3-formylchromones initiated by an unexpected aza-Michael addition." Chemical Communications 53, no. 65 (2017): 9067–70. http://dx.doi.org/10.1039/c7cc03468g.

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Анотація:

We present herein a new mode of three-component reactions between isocyanoacetates, amines and 3-formylchromones. Mechanistic and DFT studies reveals that this Ag-catalyzed process is initiated by a facile aza-Michael addition.

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19

Chen, Zhen-Zhen, Dong-Zhao Yang, Ying-Ying Dong, Mei Chi, Shou-Zhi Pu та Qi Sun. "Hf(OTf)4-Catalyzed Three-Component Synthesis of N-Carbamate-Protected β-Amino Ketones". Molecules 27, № 3 (8 лютого 2022): 1122. http://dx.doi.org/10.3390/molecules27031122.

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Анотація:

Hafnium(IV) triflate (Hf(OTf)4) has been identified as a potent catalyst for the direct three-component synthesis of β-carbamate ketones. This new method, featuring a low catalyst loading, fast reaction rate, and solvent-free conditions, provided facile access to a diversity of carbamate-protected Mannich bases. A mechanistic investigation indicated that the three-component reaction proceeds via sequential aldol condensation and aza-Michael addition, but not the Mannich-type pathway.

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20

Rather, Adil Majeed, and Uttam Manna. "Stretchable and durable superhydrophobicity that acts both in air and under oil." Journal of Materials Chemistry A 5, no. 29 (2017): 15208–16. http://dx.doi.org/10.1039/c7ta04073c.

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Анотація:

A facile and robust Michael addition reaction is strategically exploited here, to develop a highly stretchable (150% deformation) superhydrophobic material. This material strongly repels aqueous phase both in air and under oil and with impeccable physical/chemical durability, and is appropriate for rapid separation of both heavy and light oils from complex aqueous phases with above 99% efficiency.

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21

Chittimalla, Santhosh, Chennakesavulu Bandi, Vinod Gadi, and Siva Gunturu. "Facile Synthesis of 2-Arylindoles through Plancher-Type Rearrangement of 3-Alkyl-3-Arylindolenines." Synlett 28, no. 15 (July 5, 2017): 1994–99. http://dx.doi.org/10.1055/s-0036-1588448.

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Анотація:

3-Alkylindoles on reaction with a cyclohexa-2,4-dien-1-one catalyzed by BF3·OEt2 gave the corresponding 3-alkyl-3-arylindolenines in high yields through a tandem Michael addition/aromatization sequence. In the presence of HCl, these indolenine derivatives underwent a facile Plancher-type C-3 to C-2 aryl rearrangement to deliver the corresponding 2-arylindoles.

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22

Yao, Wei, Mingtai Sun, Yuannian Zhang, Hui Yang, Dong Liang, Haixia Wu, Runyan Ni, Ming Wah Wong, and Dejian Huang. "Photo-induced C–H bond activation of N,N′-dialkylethylenediamine upon aza-Michael addition to 1,8-pyrenedione: facile synthesis of fluorescent pyrene derivatives." Organic Chemistry Frontiers 5, no. 10 (2018): 1679–83. http://dx.doi.org/10.1039/c8qo00183a.

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Анотація:

We discovered a reaction between 1,8-pyrenedione and N,N′-dialkylethylenediamine to form highly fluorescent products, via aza-Michael addition followed by double C–H activation facilitated by visible light.

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23

Teimouri, Mohammad Bagher, та Tayyebeh Abbasi. "Facile synthesis of oxaspirobicyclic butenolides via a domino Michael addition/aldol reaction/γ-lactonization sequence". Tetrahedron 66, № 21 (травень 2010): 3795–800. http://dx.doi.org/10.1016/j.tet.2010.03.058.

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24

Ventura, Wellington Martins, Luiz Guilherme Souza de Assis, and Jason Guy Taylor. "ChemInform Abstract: Facile Synthesis of Indolines by a Tandem Nitro-Reduction Aza Michael Addition Reaction." ChemInform 45, no. 9 (February 14, 2014): no. http://dx.doi.org/10.1002/chin.201409128.

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25

Fustero, Santos, Javier Moscardo, Maria Sanchez-Rosello, Elsa Rodriguez, and Pablo Barrio. "ChemInform Abstract: Tandem Nucleophilic Addition-Intramolecular Aza-Michael Reaction: Facile Synthesis of Chiral Fluorinated Isoindolines." ChemInform 42, no. 12 (February 24, 2011): no. http://dx.doi.org/10.1002/chin.201112110.

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26

Suriyakala, Tevaraj, Alagiri Chinnaraj, Velmurugan Senthilkumar, Mohamedsulaiman Kamal Nasar та Gurusamy Ravindran. "Regioselective Synthesis and Antibacterial Studies of α,β-Unsaturated Ketone Substituted Cyclohexanols via Tandem Michael Addition-Aldol Addition-Cyclization Sequence under Solvent-Free Conditions". Asian Journal of Chemistry 34, № 10 (2022): 2646–50. http://dx.doi.org/10.14233/ajchem.2022.23907.

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Анотація:

A simple and facile strategy was developed involving test tube with glass-rod using a base catalyst for one-pot solid-state reaction between 1,3,5-triphenyl-pentane-1,5-dione (1) and 1,5-diphenyl-penta- 1,4-dien-3-one (2) to obtain novel 1-(5-benzoyl-2-hydroxy-2,4,6-triphenyl-cyclohexyl)-3-phenylpropenone (3) derivatives. The reaction was accomplished in good to excellent yields and the structure of a synthesized compounds was confirmed by IR, 1H NMR and 13C NMR spectral data. In this one-pot transformation, the column chromatography purification was completely avoided. Besides, the method is highly environmentally benign and atom-economical, and the side product of this reaction was only the water molecule. This green process produces significant carbocycles and offers a considerable advantages such as operational simplicity, short reaction time, high yields, and absence of tedious workup. Further, synthesized derivatives was studied against Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Pseudomonas aeruginosa).

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27

Fu, Hao, Linbo Gong, and Shuling Gong. "A New Approach Utilizing Aza-Michael Addition for Hydrolysis-Resistance Non-Ionic Waterborne Polyester." Polymers 14, no. 13 (June 29, 2022): 2655. http://dx.doi.org/10.3390/polym14132655.

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Анотація:

This work first synthesized a series of linear polyesters by step-growth polycondensation, then an amino-terminated hydrophilic polyether was grafted to the polyester as side-chains through aza-Michael addition to prepare a self-dispersible, non-ionic waterborne comb-like polyester (NWCPE). In contrast to traditional functionalization methods that usually require harsh reaction conditions and complex catalysts, the aza-Michael addition proceeds efficiently at room temperature without a catalyst. In this facile and mild way, the NWCPE samples with number-average molecular weight (Mn) of about 8000 g mol−1 were obtained. All dispersions showed excellent storage stability, reflected by no delamination observed after 6 months of storage. The NWCPE dispersion displayed better hydrolysis resistance than an ionic waterborne polyester, as was indicated by a more slight change in pH value and Mn after a period of storage. In addition, the film obtained after the NWCPE dispersion was cross-linked with the curing agent, it exhibited good water resistance, adhesion, and mechanical properties.

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28

Pal, Rammohan, Arpita Das Gupta та Asok K. Mallik. "Facile Iodine-Catalyzed Michael Addition of Indoles to α,α′-Bis(arylmethylene)cyclopentanones: An Efficient Synthesis of E-2-(3-Indolylphenylmethyl)-5-phenylmethylenecyclopentanones". ISRN Organic Chemistry 2012 (28 листопада 2012): 1–6. http://dx.doi.org/10.5402/2012/674629.

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Анотація:

Iodine-catalyzed reaction of indoles with α,α′-bis(arylmethylene)cyclopentanones afforded one diastereomer of the corresponding Michael adducts, namely, E-2-(3-indolylphenylmethyl)-5-phenylmethylenecyclopentanones, in a good yield. The products form a new group of indole derivatives.

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29

Gobbo, Pierangelo, Mark C. Biesinger, and Mark S. Workentin. "Facile synthesis of gold nanoparticle (AuNP)–carbon nanotube (CNT) hybrids through an interfacial Michael addition reaction." Chemical Communications 49, no. 27 (2013): 2831. http://dx.doi.org/10.1039/c3cc00050h.

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30

Chen, Bo, and Shengming Ma. "ChemInform Abstract: Tandem Michael Addition/Cyclization Reaction of 2,3-Allenoates with Organozincs: Facile Synthesis of Isocoumarins." ChemInform 44, no. 51 (December 2, 2013): no. http://dx.doi.org/10.1002/chin.201351165.

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31

Sun, Yanping, Hui Liu, Lin Cheng, Shimeng Zhu, Cuifang Cai, Tianzhi Yang, Li Yang, and Pingtian Ding. "Thiol Michael addition reaction: a facile tool for introducing peptides into polymer-based gene delivery systems." Polymer International 67, no. 1 (November 27, 2017): 25–31. http://dx.doi.org/10.1002/pi.5490.

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32

Chetia, Apurba, Chandan J. Saikia, Kushal C. Lekhok, and Romesh C. Boruah. "A facile synthesis of 1,7-dicarbonyl compounds via three-component Michael addition reactions." Tetrahedron Letters 45, no. 12 (March 2004): 2649–51. http://dx.doi.org/10.1016/j.tetlet.2004.01.137.

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33

Lin, Hui, Junjie Ou, Zhongshan Liu, Hongwei Wang, Jing Dong, and Hanfa Zou. "Facile construction of macroporous hybrid monoliths via thiol-methacrylate Michael addition click reaction for capillary liquid chromatography." Journal of Chromatography A 1379 (January 2015): 34–42. http://dx.doi.org/10.1016/j.chroma.2014.12.031.

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34

Teimouri, Mohammad Bagher, та Tayyebeh Abbasi. "ChemInform Abstract: Facile Synthesis of Oxaspirobicyclic Butenolides via a Domino Michael Addition/Aldol Reaction/γ-Lactonization Sequence." ChemInform 41, № 39 (2 вересня 2010): no. http://dx.doi.org/10.1002/chin.201039162.

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35

Al Majid, Abdullah M. A., Mohammad Shahidul Islam, Assem Barakat, Mohamed H. M. Al-Agamy та Mu Naushad. "Facile and Promising Method for Michael Addition of Indole and Pyrrole to Electron-Deficienttrans-β-Nitroolefins Catalyzed by a Hydrogen Bond Donor Catalyst Feist’s Acid and Preliminary Study of Antimicrobial Activity". Scientific World Journal 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/649197.

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Анотація:

The importance of cooperative hydrogen-bonding effects has been demonstrated using novel 3-methylenecyclopropane-1,2-dicarboxylic acid (Feist’s acid (FA)) as hydrogen bond donor catalysts for the addition of indole and pyrrole totrans-β-nitrostyrene derivatives. Because of the hydrogen bond donor (HBD) ability, Feist’s acid (FA) has been introduced as a new class of hydrogen bond donor catalysts for the activation of nitroolefin towards nucleophilic substitution reaction. It has effectively catalyzed the Michael addition of indoles and pyrrole toβ-nitroolefins under optimum reaction condition to furnish the corresponding Michael adducts in good to excellent yields (up to 98%). The method is general, atom-economical, convenient, and eco-friendly and could provide excellent yields and regioselectivities. Some newly synthesized compounds were for examinedin vitroantimicrobial activity and their preliminary results are reported.

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36

Filippini, Marie-Héléne, та Jean Rodriguez. "Facile Tandem Michael Addition-Retro Dieckmann Reaction of Cyclic β-Ketoesters: One-Pot Preparation of Polyfunctionalized Acyclic Derivatives". Synthetic Communications 25, № 2 (січень 1995): 245–52. http://dx.doi.org/10.1080/00397919508010813.

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37

Wang, Hai-Feng, Hua Xiao, Xiao-Wei Wang, and Gang Zhao. "Tandem intramolecular oxa-Michael addition/decarboxylation reaction catalyzed by bifunctional cinchona alkaloids: facile synthesis of chiral flavanone derivatives." Tetrahedron 67, no. 30 (July 2011): 5389–94. http://dx.doi.org/10.1016/j.tet.2011.05.088.

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38

Huang, Chao, Yanqing Yin, Jiahui Guo, Jiong Wang, Baomin Fan та Lijuan Yang. "A facile synthesis of β-amino carbonyl compounds through an aza-Michael addition reaction under solvent-free conditions". RSC Advances 4, № 20 (2014): 10188. http://dx.doi.org/10.1039/c3ra46789a.

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39

Lv, Qiulan, Ke Wang, Dazhuang Xu, Meiying Liu, Qing Wan, Hongye Huang, Shangdong Liang, Xiaoyong Zhang, and Yen Wei. "Facile preparation and biological imaging of luminescent polymeric nanoprobes with aggregation-induced emission characteristics through Michael addition reaction." Colloids and Surfaces B: Biointerfaces 145 (September 2016): 795–801. http://dx.doi.org/10.1016/j.colsurfb.2016.05.028.

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40

Chaudhari, Tohasib Yusub, Sandeep K. Ginotra, and Vibha Tandon. "Facile access to functionalized indenes and fused quinolines by regioselective 5-enolexo-dig Michael addition and cyclization reactions." Organic & Biomolecular Chemistry 15, no. 44 (2017): 9319–30. http://dx.doi.org/10.1039/c7ob02498c.

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41

Saha, Mithu, Jahar Dey, Kochi Ismail, and Amarta K. Pal. "Facile Microwave-Promoted Knoevenagel Condensation and the Combination of Knoevenagel/ Michael addition Reaction in Aqueous Medium Containing Ionic Surfactant." Letters in Organic Chemistry 8, no. 8 (October 1, 2011): 554–58. http://dx.doi.org/10.2174/157017811797249272.

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42

Yaragorla, Srinivasarao, and G. Srikanth Kumar. "ChemInform Abstract: A Facile Method for the Synthesis of Various 3-Substituted Indoles via Michael Addition Reaction Using NbCl5." ChemInform 46, no. 45 (October 22, 2015): no. http://dx.doi.org/10.1002/chin.201545134.

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43

Eid, Elshimaa M., Huwaida M. E. Hassaneen, Ismail A. Abdelhamid, and Ahmed H. M. Elwahy. "Facile one‐pot, three‐component synthesis of novel bis(heterocycles) incorporating thieno[2,3‐ b ]thiophenes via Michael addition reaction." Journal of Heterocyclic Chemistry 57, no. 5 (May 2020): 2243–55. http://dx.doi.org/10.1002/jhet.3945.

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44

Zheng, Zhihao, Pang Xiao, Huimin Ruan, Junbin Liao, Congjie Gao, Bart Van der Bruggen, and Jiangnan Shen. "Mussel-Inspired Surface Functionalization of AEM for Simultaneously Improved Monovalent Anion Selectivity and Antibacterial Property." Membranes 9, no. 3 (March 6, 2019): 36. http://dx.doi.org/10.3390/membranes9030036.

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Анотація:

A facile membrane surface modification process for improving permselectivity and antimicrobial property was proposed. A polydopamine (PDA) coating was firstly fabricated on pristine anion exchange membrane (AEM), followed by in situ reduction of Ag without adding any extra reductant. Finally, 2,5-diaminobenzene sulfonic acid (DSA) was grafted onto PDA layer via Michael addition reaction. The as-prepared AEM exhibited improved permselectivity (from 0.60 to 1.43) and effective inhibition of bacterial growth. In addition, the result of the long-term (90-h continuous electrodialysis) test expressed the excellent durability of the modified layer on membrane surface, because the concentration of Cl− and SO42− in diluted chamber fluctuated ~0.024 and 0.030 mol·L-1 with no distinct decline. The method described in this work makes the full use of multifunctional PDA layer (polymer-like coating, in situ reduction and post-organic reaction), and a rational design of functional AEM was established for better practical application.

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45

Wang, Hai-Feng, Hua Xiao, Xiao-Wei Wang, and Gang Zhao. "ChemInform Abstract: Tandem Intramolecular Oxa-Michael Addition/Decarboxylation Reaction Catalyzed by Bifunctional Cinchona Alkaloids: Facile Synthesis of Chiral Flavanone Derivatives." ChemInform 42, no. 48 (November 3, 2011): no. http://dx.doi.org/10.1002/chin.201148143.

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46

Huang, Chao, Yanqing Yin, Jiahui Guo, Jiong Wang, Baomin Fan та Lijuan Yang. "ChemInform Abstract: A Facile Synthesis of β-Amino Carbonyl Compounds Through an Aza-Michael Addition Reaction under Solvent-Free Conditions." ChemInform 45, № 40 (18 вересня 2014): no. http://dx.doi.org/10.1002/chin.201440038.

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47

FILIPPINI, M. H., and J. RODRIGUEZ. "ChemInform Abstract: Facile Tandem Michael Addition-Retro Dieckmann Reaction of Cyclic . beta.-Ketoesters: One-Pot Preparation of Polyfunctionalized Acyclic Derivatives." ChemInform 26, no. 25 (August 17, 2010): no. http://dx.doi.org/10.1002/chin.199525088.

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48

Xiong, Kaiqin, Pengkai Qi, Ying Yang, Xiangyang Li, Hua Qiu, Xin Li, Ru Shen, Qiufen Tu, Zhilu Yang, and Nan Huang. "Facile immobilization of vascular endothelial growth factor on a tannic acid-functionalized plasma-polymerized allylamine coating rich in quinone groups." RSC Advances 6, no. 21 (2016): 17188–95. http://dx.doi.org/10.1039/c5ra25917g.

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Анотація:

Biomolecules like VEGF with thiol or amine groups can easily be covalently immobilized onto a Tannic Acid functional plasma polymerized allylamine surface rich in quinone groups in a mild alkali buffer solution based on Schiff base or Michael addition reactions.

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49

Nayab, Sana, Vanessa Trouillet, Hartmut Gliemann, Peter G. Weidler, Iqra Azeem, Saadia R. Tariq, Anja S. Goldmann, Christopher Barner-Kowollik, and Basit Yameen. "Reversible Diels–Alder and Michael Addition Reactions Enable the Facile Postsynthetic Modification of Metal–Organic Frameworks." Inorganic Chemistry 60, no. 7 (March 17, 2021): 4397–409. http://dx.doi.org/10.1021/acs.inorgchem.0c02492.

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50

Pesyan, Nader Noroozi, Narmin Akhteh, Hana Batmani, Barış Anıl, and Ertan Şahin. "A Facile and Catalyst-free Synthesis of Hexahydroacridine-1,8(2H,5H )-dione and Octahydroacridin-10(1H )-yl)thiourea Derivatives: Inter- and Intramolecular Aza-Michael addition." Heterocyclic Communications 26, no. 1 (March 10, 2020): 26–32. http://dx.doi.org/10.1515/hc-2020-0005.

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Анотація:

AbstractAn easy and convenient technique for the one-pot synthesis of novel compounds of hexahydroacridine-1,8(2H,5H)-dione and octahydroacridin-10(1H)-yl) thiourea derivatives has been developed by the reaction of the octahydro-1H-xanthenes with hydroxylamine hydrochloride and thiosemicarbazide in ethylene glycol, which is a green solvent, under mild reaction conditions. IR, 1H NMR, 13C NMR spectrometry, and X-ray diffraction analysis were used to identify the structures of these compounds.

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