Дисертації з теми "Facile Michael Addition Reaction"
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Budhavaram, Naresh Kumar. "Facile protein and amino acid substitution reactions and their characterization using thermal, mechanical and optical techniques." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/40340.
Повний текст джерелаPh. D.
Jha, Sushil C. "Catalytic, enantioselective michael addition reaction." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2002. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2496.
Повний текст джерелаLombardi, Federico. "Computational study on the asymmetric aminocatalysed Michael addition reaction of cyclohexanone to trans–β–nitrostyrene". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/23186/.
Повний текст джерелаZhu, Sunsheng. "Novel Approach to Polyhedral Oligmeric Silsesquioxane-Based Giant Surfactants Basd on Thiol-Michael Addition "Click" Reaction." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1399555570.
Повний текст джерелаLi, Mao. "Iron(III) catalyzed asymmetric Diels-Alder reaction - Iron(II) catalyzed thia-Michael addition and aldehyde allylation reactions." Doctoral thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/34969.
Повний текст джерелаIron catalysts are employed in three different organic transformations owing to their advantages: environmental friendliness, being less expensive and abundant on the Earth. The first project deals with asymmetric Diels-Alder reactions of α, β-unsaturated oxazolidin-2-one derivatives catalyzed by Fe¹¹¹ and a chiral bipyridine ligand. In order to obtain the optimized reaction conditions, we screened different solvents, catalyst loading, various reaction times and a variety of iron salts such as Fe(ClO₄)₂·6H₂O, Fe(ClO₄)₂·6H₂O, Fe(OTf)₃, Fe(OTf)₂, FeCl₂, FeCl₃, FeBr₃ and FeI₃. As a result, the reaction between cyclopentadiene and 3-alkenoyl-1,3-oxazolidin-2-one was carried out at –30 °C in CH₃CN in 1.5 h, with Fe(ClO₄)₃·6H₂O (2 mol%) complexed with the chiral bipyridine ligand (2.4 mol%) as catalyst, providing an excellent yield (99%) and an excellent enantiomeric excess (98%). Decreased enantioselectivities were observed for less-reactive dienes. Overall, less than 10 mol% of catalyst loading was employed. The great advantages of this project are the mild reaction temperature, very low catalyst loading, excellent yields and enantioselectivities and the applicability to a wide scope of substrates. Meanwhile, iron catalysts were used in thia-Michael additions by two different approaches. The first one is about thia-Michael additions catalyzed by Fe(OTf)₂ in EtOH at room temperature. This green method allows the thia-Michael additions to be catalyzed by a green iron salt (5 mol% of Fe(OTf)₂), a green and commonly used solvent EtOH at room temperature under ambient atmosphere. The generality of this reaction was demonstrated by applying it to different Michael acceptors, and to aromatic and aliphatic thiols. The second method is about thia-Michael additions catalyzed by Fe(OTf)₂ in 2-Me-THF, which is in agreement with the green chemistry principles by using a green Fe(OTf)₂ and a green solvent 2-Me-THF at room temperature or 50 °C under air atmosphere. The last project is about asymmetric allylation reactions catalyzed by Fe(OTf)₂ using a chiral ligand. With the study of a variety of chiral ligands, we selected 5 mol% of Fe(OTf)₂ and 6 mol% of Pybox ligand which catalyzed the reaction in good yield (70%) and 32% of ee. The utilization of 20 mol% of TMSCl is essential for the effectiveness of the reaction
LOPS, CARMINE. "Development of organocatalytic and stereoselective reactions." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2918472.
Повний текст джерелаIbrahim, Houssein. "Synthèse de nouveaux composés chiraux à partir d'isosorbide et d'isomannide : applications en catalyse asymétrique." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112159.
Повний текст джерелаThe Thesis deals with the synthesis of new chiral compounds derived from isosorbide and isomannide and their applications to asymmetric catalysis. The first part of this work consisted in perfecting the chemical and enantioselective hydrogenation conditions of olefins using chiral monophosphines as ligands (up to 96% ee). These phosphines were also used as organocatalysts for [3+2] cyclisation reactions showing good catalytic activity and moderate enantioselectivity. The second part turned to the synthesis of a series of chiral nitrogen compounds which were evaluated in the asymmetric transfer hydrogenation of aromatic ketones giving good enantioselectivity (up to 73% ee). The complexes formed with amine ligands were also applied to the addition reaction of phenylacetylene to imines. Good catalytic activity but low enantioselectivity were observed. These nitrogen compounds were also used as organocatalysts in the Michael addition reaction of aromatic ketones to the nitrostyrene. Again, low enantiomeric excess was obtained. The last part of this work consisted in preparing new chiral thiourea compounds which were applied as organocatalysts to the Friedel-Crafts alkylation reaction of different indoles with nitroolefines, and to the conjugate addition reaction of hydroxylamines to pyrazoles derivatives for the synthesis of β-amino acids. In two cases, these catalysts have proved active but not enantioselective
Guedeney, Nicolas. "Vers la vectorisation des bisphophonates par les peptides de pénétration cellulaire." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCD024.
Повний текст джерелаNowadays, one of the main strategies for pharmacokinetic modifications of bioactive compounds is their vectorization and the synthesis of prodrug derivatives. This work is focused on the vectorization of phosphorus antitumor agents with cell-penetrating peptides. We have then conjugated aminoalkyl-bisphosphonates with peptidic sequence to modify their retention time and increase their cellular internalization. Several linkers bearing an insaturated carbonyl moiety have been evaluated in conjugation by aza- and thia-Michael addition reaction to obtain a conjugated peptide-alendronate compounds. A prodrug approach has been conducted with the synthesis of bisphosphinate derivatives and an analog of alendronate has been obtained
Léger, Frédéric. "Additions d'énamines β-lithiées sur des esters α, β-éthyléniques. Nouvelles propriétés des énamines β-halogénées". Rouen, 1996. http://www.theses.fr/1996ROUES051.
Повний текст джерелаGoudedranche, Sébastien. "Réactions domino organocatalysées énantiosélectives à partir de cétoamides." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4354.
Повний текст джерелаThis work focused on the development of novel enantioselective transformations combining Multiples Bond-Forming Transformations and organocatalysis which are modern tools of organic synthesis in order to synthetize molecules of structural and biological interests. In this context, we developed two new Michael addition initiated domino reactions. The first one, a domino Michael addition-acylation, allows the synthesis of optically active spiroglutarimides starting from β-ketoamides and α,β-unsaturated acyles cyanides as new biselectrophiles.The second one, a domino Michael addition-hemiaminalizationhemiacetalization, allows the synthesis of seven-membered aza-cycles using α-ketoamides as new bis-nucleophiles
Meng, Xiangtao. "Chemical Modification of Cellulose Esters for Oral Drug Delivery." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/71383.
Повний текст джерелаPh. D.
Dias, Rafael Mafra de Paula. "Adições de aza-Michael em diazocetonas α,β-insaturadas e reações de inserção em ilídeos β-cetosulfoxônios." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-23032016-092522/.
Повний текст джерелаThis thesis is divided into two chapters which are related to the chemistry of α,β-unsaturated diazoketones and β-ketosulfoxonium ylides. The first chapter presents the utility of α,β-unsaturated diazoketones as new aza-Michael acceptors. Conjugate addition of primary and secondary amines was explored, as well as the use of chiral amines to evaluate the asymmetric version of the reaction. In addition to the formation of these adducts, it was also investigated some strategies for the synthesis of 2- and 3-pyrrolidinones via the \"one-pot\" protocols (starting directly from the α,β-unsaturated diazoketones). Finally, the synthesis of the natural product Barmumicyn was evaluated from this methodology. The second chapter aimed to investigate the use of β-ketosulfoxonium ylides as diazocarbonyl compounds substitutes in insertion reactions. At first, the intermolecular S-H insertion reaction was studied aiming the construction of the β-ketothioether fragment. Some competitive and mechanistic studies, as well as asymmetric versions are also part of the scope. Secondly, some ylides were also employed in intramolecular N-H insertion reactions (from sulfoxonium amino acid derivatives) aiming the formation of 3-azetidinones.
Yang, Jing. "Synthèse et évaluation en catalyse asymétrique de nouveaux complexes de terres rares." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112381.
Повний текст джерелаThis thesis is mainly devoted to the development of two families of rare earths chiral binaphtolate complex and their application in asymmetric catalysis such as Michael addition, Henry reaction, Strecker reaction and hydroalkoxylation reaction. At first, the preparation of a new family of rare earth bisbinaphtolate complexes has been optimized with complete characterizations including NMR, IR, mass spectroscopy and XRD studies on isolated single crystals. These new rare earths complexes are relative stable which can be used under air condition. The catalytic behavior of these new heterobimetallic complexes have been studied in detail: an isoinversion temperature was determined and the nonlinear effect was observed for asymmetric Michael additions of malonates on enones wich lead products with enantiomeric excess up to 83%. Secondly, a family of rare earth monobinaphtolate monoalkyl complexs has been synthesized and characterized. The first XRD structure of this family of complex was obtained. Steric substitutions of binaphtolate ligands on position 3,3’ have been proven to be essential for the formation of these complex. The selectivity of reaction of hydroalkoxylation of allene was studied with a proposed mechanism. First examples of asymmetric hydroalkoxylation of alkene catalyzed by rare earth complexes have been achieved by our rare earth monoalkyl monobinaphtolate complex
Cannillo, Alexandre. "Association de la condensation de Petasis à des réactions de cyclisation pour la synthèse de molécules d’intérêt biologique." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112263/document.
Повний текст джерелаTo develop new synthetic tools, we developed variants of the Petasis reaction. The use of α-amino aldehydes in the Petasis reaction allowed to synthesize chiral diamines with a total diastereoselectivity. The reaction gave good results with different protective groups of the amine (sulfonamide, carbamate, amide). However, during the reaction, the amino aldehydes are epimerized and the enantiomeric excess of the prepared diamines is low (30%). The Petasis reaction was associated with the Diels-Alder reaction in a domino process to achieve the preparation of hexahydroisoindole type compounds. The domino reaction is completely diastereoselective and the molecules are obtained as enantiopure. A second domino process, using a cross-metathesis reaction followed by an intramolecular 1,4-addition, yielded compounds with a morpholine moiety in a diastereoselective manner. Intramolecular version of the Petasis reaction was developed in order to obtain carbon-six-membered rings. This reaction led to the preparation of (+)-conduramine C-4 in few steps. The cyclization has shown a surprising diastereoselectivity since the configuration between the newly formed amine and alcohol is trans. This configuration is opposite to the one obtained in the intermolecular versions
Pinheiro, Danielle Lobo Justo. "Síntese de um novo organocatalisador derivado da d-galactose e aplicação em reação do tipo Michael." Universidade Federal de Juiz de Fora, 2015. https://repositorio.ufjf.br/jspui/handle/ufjf/318.
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CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Carboidratos têm sido utilizados como organocatalisadores em síntese orgânica devido a sua quiralidade intrínseca. Neste trabalho foi sintetizado um novo organocatalisador aproveitando a estrutura da D-galactose como indutor de quiralidade. A síntese ocorreu em cinco etapas, a saber: proteção seletiva das hidroxilas das posições 1, 2, 3 e 4, seguida pela iodação da posição 6, substituição nucleofílica pelo grupo azido, redução à amina e por fim uma reação com anidrido ftálico. O rendimento global foi de 60 %. O organocatalisador foi testado na reação de adição de Michael entre o dibenzilideno acetona e a azalactona derivada da alanina. 20 mol% do catalisador conduziu ao produto com 57 % de rendimento e com total controle da régio- e diasteroseletividade. No escopo, vários produtos com funcionalização no esqueleto de dbas foram preparados e devidamente caracterizados pelas técnicas convencionais de análise. A determinação da estereoquímica relativa foi realizada através do uso de HPLC com fase estacionária quiral e foi atribuída como 1,2-anti após a comparação do tempo de retenção com um padrão já descrito na literatura. De maneira geral, é reportada, pela primeira vez, uma metodologia mais geral para a dessimetrização diasterosseletiva entre dbas e azalactonas catalisadas por ácido de Brønsted.
Carbohydrates have been used as organocatalysts in organic synthesis due to its inherent chirality. In this work, D-galactose was choose as a chiral pool in the catalyst design and it was prepared in five steps: selective ketalyzation of hydroxyl groups, following by an iodination and nucleophilic substitution in the presence of azide. To complete, reduction of the azide to amine and a coupling reaction with phthalic anhydride leading to the catalyst. Overall yield was 60 % for five steps. Then, the catalyst was adopted in the Michael addition reaction between dibenzylidene acetone and azalactone derivative of alanine. The product was obtained in 57% yield and with fully control of both regio- and diastereoselectivity. Next, various funcionalizated dbas were evaluated under the optimized reaction condition and the corresponding final products were fully characterized through conventional elemental analysis. The relative stereochemistry was assigned as being 1,2-anti by using chiral HPLC method. To this end, an authentic sample already described in the literature was prepared in order the retention time. In general, for the first time, a method more general to perform a diastereoselective dessymetrization of dbas in presence of azlactones by using a Brønsted acid as catalyst was described.
Baron, Marc. "Développement de nouvelles méthodologies pour la synthèse de spirotétrahydro-β-carbolines". Phd thesis, Université Claude Bernard - Lyon I, 2014. http://tel.archives-ouvertes.fr/tel-00985371.
Повний текст джерелаJubault, Philippe. "Génération électrochimique de carbanions α-phosphorés α, α-dihalogénés : électrosynthèse de gem-dihalogénoalcènes et de cycloalkylphosphonates. Mise en évidence d'un phénomène d'activation électrochimique du magnésium". Rouen, 1996. http://www.theses.fr/1996ROUES018.
Повний текст джерелаKoeth, Richard A. II. "The Green Functionalization and Crosslinking of Polyisobutylenes for Bioadhesive Employment." University of Akron / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=akron1353178867.
Повний текст джерелаDuflos, Jack. "Synthèse et réactions de cycloadditions sur des systèmes pyrroliques à noyaux condensés." Rouen, 1987. http://www.theses.fr/1987ROUES003.
Повний текст джерелаTALAGA, PATRICE. "Synthese et activite biologique de tolerogenes potentiels." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR13101.
Повний текст джерелаCiccolini, Cecilia. "Synthesis of Mono and Poly-Heterocycles starting from 1,2-Diaza-1,3-Dienes (or precursors) as Building Blocks." Doctoral thesis, Urbino, 2020. http://hdl.handle.net/11576/2674162.
Повний текст джерелаDey, Nilanjan. "Engaging Small Organic Molecules and Self-Assemblies for ‘Label-Free’ Recognition of Biologically Relevant Analytes." Thesis, 2016. https://etd.iisc.ac.in/handle/2005/4908.
Повний текст джерела陳恩涵. "Organocatalyzed Intramolecular Michael Addition Reaction." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/37268852645833421689.
Повний текст джерела國立臺灣師範大學
化學系
102
Asymmetric organocatalytic Michael addition has attracted interests due to its environmental friendliness and the generation of multiple stereogenic centers in a single step. In this study‚ treatment of (E)-5-nitro-6-arylhex-5-en-2-one using a catalytic amount of quinine-derived primary amine (20 mol%) and 4-dimethyl aminopyridine (20 mol%) in 1,4-dioxane and DMSO (1:1) at 50 oC to give 3,4-trans- disubstituted cyclohexanones via intramolecular Michael addition process with moderate chemical yields and high-to-excellent stereoselectivities (>95:5 dr and up to 96% ee). We describe a rapid and practical synthetic route involving six-step reaction toward the synthesis of (-)-Epibatidine
Wu, Na (Anna), B. Wahl, S. Woodward, and W. Lewis. "1,4‐Addition of TMSCCl3 to nitroalkenes: efficient reaction conditions and mechanistic understanding." 2014. http://hdl.handle.net/10454/17854.
Повний текст джерелаImproved synthetic conditions allow preparation of TMSCCl3 in good yield (70 %) and excellent purity. Compounds of the type NBu4X [X=Ph3SiF2 (TBAT), F (tetrabutylammonium fluoride, TBAF), OAc, Cl and Br] act as catalytic promoters for 1,4‐additions to a range of cyclic and acyclic nitroalkenes, in THF at 0–25 °C, typically in moderate to excellent yields (37–95 %). TBAT is the most effective promoter and bromide the least effective. Multinuclear NMR studies (1H, 19F, 13C and 29Si) under anaerobic conditions indicate that addition of TMSCCl3 to TBAT (both 0.13 M ) at −20 °C, in the absence of nitroalkene, leads immediately to mixtures of Me3SiF, Ph3SiF and NBu4CCl3. The latter is stable to at least 0 °C and does not add nitroalkene from −20 to 0 °C, even after extended periods. Nitroalkene, in the presence of TMSCCl3 (both 0.13 M at −20 °C), when treated with TBAT, leads to immediate formation of the 1,4‐addition product, suggesting the reaction proceeds via a transient [Me3Si(alkene)CCl3] species, in which (alkene) indicates an Si⋅⋅⋅O coordinated nitroalkene. The anaerobic catalytic chain is propagated through the kinetic nitronate anion resulting from 1,4 CCl3− addition to the nitroalkene. This is demonstrated by the fact that isolated NBu4[CH2=NO2] is an efficient promoter. Use of H2C=CH(CH2)2CH=CHNO2 in air affords radical‐derived bicyclic products arising from aerobic oxidation.
Engineering and Physical Sciences Research Council (EPSRC) Grant EP/K000578/1.
You, Ruei-Yi, та 游瑞益. "Preparation of Chiral α-Phosphono α,β-Alkenoates and Application into Michael Addition Annulation Reaction". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/19265831436958423783.
Повний текст джерелаchuan, yang sheng, та 楊盛全. "β-amino-α,β-unsaturated,γ-thiolactone's Diels-Alder reaction and Lewis acid catalyze Michael addition". Thesis, 1999. http://ndltd.ncl.edu.tw/handle/59276036791545422650.
Повний текст джерела朝陽大學
應用化學研究所
87
We build our lab's method to synthesize β-amino-α,β-unsaturated,γ-thiolactone 1 (achiral)、2 (chiral), and have good yield. From thiolactone 1、2, we have to synthesize thiophene 3、4, and study thiophene's Diels-alder reaction and Lewis acid catalyze Michael addition
li-hsiang, Cheng, та 鄭禮翔. "Synthesis of chromanol derivatives from α,β-unsaturated ketones and aliphatic aldehydes via Michael addition reaction". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/45954819004561384470.
Повний текст джерела國立臺灣師範大學
化學系
102
This thesis describes the synthesis of benzoyl-substituted chromanol derivatives from α,β-unsaturated ketones and aliphatic aldehydes via Michael addition reaction. These derivatives appear as interesting intermediates in the synthesis of various natural products and biologically active compounds. Different types of α,β-unsaturated ketones (57,63) were allowed to react with aliphatic aldehyde to obtain the same products 64aa and 64ab. It’s worth mentioning that starting from either 57 or 63 as starting material, the diastereo orientation of products were different. For example, using coumarin derivatives (57) as the starting material, the major product was obtained in anti orientation (64aa). But starting from chalcone derivatives (63), the major product was obtained with syn orientation (64ab).
Chang, Geng-Hua, and 張耕華. "Organocatalytic Enanotioselective Synthesis of Tetrahydrofluoren-9-9ones via Vinylogous Michael Addition/Henry Reaction Cascade of 1,3-Indandion-Derived Pronucleophiles." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/54334980763310943840.
Повний текст джерела國立臺灣師範大學
化學系
104
Bifunctional organocatalyst dominated for asymmetric catalysis via utilizing novel 1,3-indandionederived pronucleophiles with wide variety of nitoalkenes for Vinylogous Michael addition/Henry cyclization cascade to generate tetrahydrofluoren- 9-ones derivatives with excellent result. Part I: An unprecedented organocatalytic enantioselective vinylogous Michael addition/Henry cyclization cascade is presented for the synthesis of highly substituted tetrahydrofluoren-9-ones employing novel 1,3-indandionederived pronucleophiles 94 and nitroalkenes. Following a very simple protocol, a wide range of products were obtained in good to excellent yields and with excellent enantioinduction (43−98% yield, up to 98% ee). The reaction proceeded with excellent diastereocontrol despite the simultaneous generation of four stereogenic centers. Surprisingly, when 2- (1- phenylethylidene)-1H-indandione 94h-i was used as a pronucleophile, no cyclization was observed, and only Michael addition adducts 98 were furnished in very good yields and excellent enantioselectivities. Part II: An enantioselective synthesis of benzopyrano[3,4-c]pyrrolidine derivatives via organocatalyzed [3+2] cycloaddition has been achieved. Cinchona alkaloid-derived organocatalysts as Bronsted bases have been examined for this asymmetric cycloaddition of o-hydroxy aromatic aldimines with 3-substituted coumarins. An unexpected rearrangement of the quaternary acyl moiety in the products resulted in an in situ protection of the o-hydroxy group.
Chen, Yi-Ju, and 陳怡如. "The Study on Asymmetric Michael Addition Reaction of Ketones to Chalcones Catalyzed by Camphorsulfonamide-Derived (2S,4R)-4-Hydroxy-L-Prolinamide." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/r36ctc.
Повний текст джерела國立清華大學
化學系
102
This thesis dealt with the synthesis and application of novel prolinamide-camphor organocatalysts that derived from the coupling of trans-4-hydroxy-L-proline and camphorsulfonamide. Organocatalyst 11d is proven to be an efficient catalyst for the asymmetric Michael reaction of ketone and a series of chalcone-derived. Treatment of cyclohexanone with chalcone- deriveds which have electron-withdrawing group using organocatalyst 11d provided the desired Michael products with high chemical yields (up to 97% yield), excellent diastereoselectivities (up to 99/1 dr) and high levels of enantioselectivities (up to 93% ee) for syn- products.
Hsu, Jianming, та 許建銘. "Molecular Iodine-Catalyzed Michael Addition of Pyrrole and Indole and Molecular Iodine-Catalyzed Mannich-Type Reaction to Synthesize β-Amino Carbonyl Compounds". Thesis, 2005. http://ndltd.ncl.edu.tw/handle/12677711269792641637.
Повний текст джерелаYalalov, Denis. "Bifunctional Thiourea-Based Organocatalysts for Asymmetric C-C Bond Formation Reactions: Strecker, Nitro-Michael, Mannich." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-0006-ACA2-6.
Повний текст джерелаHung, Hsiu-Yin, and 洪秀銀. "Michael Addition Studies of b-amino, a,b-unsaturated-g-thiolactone under Lewis acid condition and Chiral Anti-Aldol Reaction with Synthetic applications of Chiral Vinylogous Urethanes." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/05634826383446734589.
Повний текст джерела朝陽大學
應用化學系碩士班
88
Abstract 一. Michael Addition Reaction of b-amino, a,b-unsaturated-g-thiolactone under Lewis acid conditions. 4-(1-pyrrolidinyl)-2(5H)thiophenon 1, which developed in our laboratory was used to study it''s Michael reaction under Lewis acid conditions. Their reaction products were analyzed using HPLC techniques to determine diastereoselectivity. 二.Chiral Anti-Aldol Reaction Studies of Chiral Vinylogous Urethane and their Application in Natural Product Synthesis. 1. Camphor derived chiral vinylogous urethane 3 was deprotonated and reacted with aldehyde to from anti-aldol product, the product selectivity was analyzed using chiral column to determine their enantioselectivity. 2. Product 5 was used to synthesize Bafilomycin A1 fragment prelactone B.