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1
Vermeersch, Sabine Anne. "Investigation of the F117A vortical flow characteristics." Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/49908.
Повний текст джерела
2
Haddemo, Peter, and Jenny Siljehög. "Viktreducering av hydraulmaskin F11-010." Thesis, Högskolan Väst, Institutionen för ingenjörsvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-2997.
Повний текст джерелаАнотація:
Möjligheter att reducera vikten på en hydraulmotor, som tillverkas på Parker Hannifin AB i Trollhättan, har studerats. Målet med arbetet var att ge förslag på hur motorn kan göras lättare för att nå det framtida målet att erbjuda kunder en lättviktsmotor (LWM) lämpad som fläktmotor. För att identifiera komponenterna och deras vikter vägdes alla delar var för sig. Värdena visade att trumhus, lagerhus, axel och lagerpaket stod för ca 75 % av motorns totala vikt. Arbetet koncentrerades därför på att reducera vikten på dessa delar. Flera koncept togs fram med lägre vikt och bibehållen prestanda. Vissa delar kontrollerades mot hållfasthet med handberäkningar och FEM-analyser. Enligt beräkningarna finns möjlighet att reducera vikten med 45 %. Om hydraulmotorn konstrueras enligt koncepten, bör det framtida målet kunna nås, till-verkning av en lättviktsmotor som är betydligt lättare än dagens hydraulmotor.<br>The weight reducing possibilities for a hydraulic motor, produced by Parker Hannifin AB in Trollhättan, have been investigated. The goal was to provide suggestions for weight optimization to offer customers a light weight motor (LWM) that is well suited as a fan motor. The mass of each part was determined and their functions were identified. The result showed that the housings, shaft and bearings represented 75% of the motor’s total mass. The work was thus concentrated to these parts. Multiple suggestions were generated where weight and performance were taken into consideration. Some parts were analyzed with the aid of FEA-software and hand calculations. The result indicates that a weight reduction of 45% is possible. If the hydraulic motor is redesigned according to the concepts, the goal of a light weight motor can be achieved.
3
Ma, Wenwei. "Protein-nanoparticles interaction and assembly." Thesis, University of Lincoln, 2017. http://eprints.lincoln.ac.uk/30884/.
Повний текст джерелаАнотація:
Nanoparticles are increasingly important in biotechnology as they are extensively used as drug delivery carriers and in biosensors. In both these two contexts, protein-nanoparticle interactions are often involved. Proteins that are present in body fluids inevitably interact with nanoparticle based drug carriers and typically surround them forming the so called “protein corona”. Biosensors that are based on nanoparticles often have proteins deliberately attached to their surface, for example antibodies that bind specific analytes. The understanding of the assembly mechanisms at the protein-nanoparticle interface and the ability to engineer proteins that interact with nanoparticles in the desired way, are therefore two essential requisites for the future development of nano-medicines and nano-biosensors. In this work, we focused on the interaction of proteins with gold nanoparticles (GNPs). GNPs are available with a broad range of surface chemistries, suitable for the conjugation of many biomolecules. Although there are at least three decades of studies on gold colloids with different surface chemistries, there is still quite little known about what are the exact features of a protein that determine its adsorption onto gold. We developed methods to study this and applied them to characterise the adsorption on GNPs of Glutathione-S-Transerase (GST), which was reported previously as a protein that strongly binds gold. We determined its affinity and kinetics of binding and unravelled the mechanism of its thiol-mediated chemisorption. We found that GST binds to GNPs even more efficiently than other known gold-binding proteins, such as Bovine Serum Albumin (BSA). We concluded that GST could be considered a very useful gold-protein interface, especially considering that GST fusion is routinely used for affinity purification of recombinant proteins and therefore well established. We also fused self-assembling proteins to GST or chemically cross-linked them to BSA. The scope was to explore the feasibility of hierarchical and ordered assembly of designer proteins onto GNPs, with the ultimate goal of providing a convenient tool for modular assembly of proteins onto nanomaterials. It is known that proteins tend to denature and lose their function when in contact with GNPs, which is not optimal for biosensors or in nanomedicine. We found that it is possible to use GST or BSA to form a sacrificial layer on gold, which exposes linked, self-assembling proteins that are able to bind their counterpart, unaffected by the GNP surface. We reported two proof-of-concepts: the first based on mimics of the self-assembling neuronal SNARE proteins and the second based on the pair SpyCatcher/SpyTag, derived from Streptococcus pyogenes proteins and used in bio-conjugation for their ability to self-catalyse the formation of isopeptidic bonds. We believe that the novel methods and original results presented in this thesis apply to both the understanding and the engineering of the protein-nanoparticle interface and will be beneficial for the broad nanobiotechnology community. In fact, our findings have potential applications in a broad range of fields, spanning from the improvement of the circulation life-time of nanomedicines by preventing the binding of serum protein and opsonisation, to the improvement of the manufacturing of GNPs-based immune-biosensors such as those used in lateral flow devices.
4
Karatasios, Ioannis. "The effect of barium hydroxide on the physicochemical properties of lime-based conservation mortars." Thesis, De Montfort University, 2005. http://hdl.handle.net/2086/13255.
Повний текст джерелаАнотація:
The research undertaken concerns the analysis of original Byzantine mortars and the study of new compatible lime-based mixtures, for conservation purposes, which present enhanced resistance to sulphates. The thesis focuses on the effect of barium hydroxide, as an additive, to both the physicochemical properties and the durability of conservation mortars. Both binary pastes and mortar mixtures, containing varying amounts of barium hydroxide, were prepared and their physicochemical properties and durability determined. Comparisons were made with a reference mixture containing no barium hydroxide. The laboratory mixtures were synthesised according to the analysis of original mortars, collected from six different Byzantine mosaic pavements. The durability of the mortar mixtures against sulphate action was studied through the use of accelerated aging tests: crystallisation of soluble salts; electrochemical degradation; sulphate fixation; and resistance to leaching of cementing material. The results of these tests were considered together with the physical properties of the mortars, since these also influence their durability. From the interpretation of the results it was shown that the setting of lime-based barium mixtures can be described by two mechanisms; the carbonation process of calcium hydroxide and barium hydroxide; and the precipitation of a barium calcium carbonate [BaCa(CO3)2] solid solution. It has been shown that the presence of barium hydroxide in lime-based mortars has a physical effect on the pore space characteristics of the mortar. It has also been shown that its presence improves the durability of the mortar, playing a protective role against sulphate attack.
5
Edwards, Stephen John. "Measurement of halides in photographic emulsions." Thesis, University of Bedfordshire, 2003. http://hdl.handle.net/10547/622158.
Повний текст джерелаАнотація:
Conventional Ag/AgX electrodes, responsive to halide X, cannot be used to monitor the addition of a second halide Y since such additions result in a slow chemical conversion of the macroscopic halide coating AgX to AgY. This is a serious problem in the manufacture of photographic emulsions that frequently contain more than one silver halide. The thesis describes a new electrochemical measurement technique with the ability to make appropriate determinations in solutions of mixed halides. In the new technique (termed "clean/coat/measure"), silver electrodes were prepared "in situ" by applying square wave pulses to the electrode. First the previous halide layer was removed, then the electrode was coated in situ with a new layer of silver halide and this was used to measure the open circuit potential before the cycle was repeated. In this way the halide coating reflected the composition of the measurement solution. Existing commercial instrumentation was inappropriate for the proposed measurement sequence. Thus, a range of instrument hardware and software was designed and built by the author and used to study the influences of a multitude of parameters on the measurement performance. 1. A stable and accurate measurement system was designed and fabricated allowing the potentials of eight electrodes to be measured simultaneously in grounded solutions. Data was collected and stored on a PC using custom written software. Calibration curves for conventional silver/silver chloride, bromide and iodide electrodes were obtained over a range of concentrations and temperatures. Silver/silver halides electrodes with small surface areas (< 9 mm2) and thin halide coatings (< 1 nm thick) were studied to ensure that such electrodes performed as conventional large, thickly coated electrodes. Calibration curves showed no deterioration of response due to small surface areas and, over short time scales (< 2 min), no deterioration due to thin layers. 2. A laboratory instrument was designed and built to apply potential pulses, control a rotating disc electrode (RDE) and collect data. The system allowed both controlled potential pulses to be applied to the electrodes and open circuit potentiometric measurements to be made. Measurements of potential and current were collected at a rate of 10,000 measurements per second. The system used custom software running on a PC to control the instrumentation and to store data on the PC. Using this instrumentation a RDE was used to study the new "clean/coat/measure" pulsed technique. Results from the RDE study indicated that an electrode capable of sensing halide could be produced by this technique if an applied potential pulse with sufficient charge was applied. This minimum charge (11 x w-s C cm-2) produced a coating thickness approximately equivalent to a monolayer. The study also indicated that the technique was independent of the speed of rotation of the silver electrode and was successful over a wide range of conditions of pulse time, applied potential and cycle times for solution of potassium bromide in the range 0.001 to 0.05 M. The technique also successfully measured the addition of potassium iodide to a solution of potassium bromide while conventional thickly coated electrodes did not. 3. Two further instrumentation systems were designed and built to be used in a grounded stainless steel emulsion making vessel , one to apply controlled potential pulses and one to apply constant current pulses. Using these instruments and the conditions found for the RDE, static cylindrical electrodes in stirred solutions were investigated using both controlled potential and constant current square wave pulses of between 50 and 500 ms. Both potential step and current step techniques successfully measured the halide concentration of solutions of potassium chloride and bromide (0.001 to 0.5 M) and potassium iodide (0.0001 to 0.5 M). Both methods were also shown to be able to successfully monitor the addition of iodide to bromide and chloride solutions. With respect to future work, modifications to the instrumentation are proposed, including the replacement of the PC by an on-board microprocessor, the design of a multi-channel system and use of intelligent software to determine the optimum potential or current to apply. Areas of work required to be carried out before the system could be used in a production environment are given.
6
Silvester, Debbie Sue. "Electrochemical studies in room temperature ionic liquids." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:be9e6269-f19a-48de-96e3-41c0c7143d6a.
Повний текст джерелаАнотація:
The work presented in this thesis involves the application of room temperature ionic liquids (RTILs) as solvents for use in electrochemical experiments. Initially, the fundamentals of electrochemistry is presented, followed by a comprehensive overview of RTILs in terms of their properties, applications and their behaviour as electrochemical solvents compared to conventional aprotic solvents. The results of 8 original studies are then presented as follows: X-Ray photoelectron spectroscopy is used to quantify the concentration of bromide ions in an ionic liquid, and is independently confirmed by potential-step chronoamperometry. The reaction mechanisms and kinetics for the electrochemical reduction of some aromatic nitro compounds (namely nitrobenzene and 4-nitrophenol) are determined. The electrochemistry of phosphorus trichloride and phosphorus oxychloride is studied in detail for the first time, due to the unusual stability of these highly reactive compounds in RTILs. The reductions and oxidations of sodium and potassium nitrate are studied, giving rise to 'melt'-like behaviour. The electrodeposition of sodium oxide on platinum is also demonstrated. The electrochemical oxidation of nitrite and the oxidation and reduction of the toxic gas, nitrogen dioxide, is presented. The oxidation of hydrogen gas is studied in ten RTILs with a range of different cations and anions, and contrasting interactions with the RTIL anions are seen. The electrochemical oxidation of ammonia gas is studied in five RTILs with different anions and a general reaction mechanism is suggested. The reduction of benzoic acid is studied in six RTILs, and the kinetics of the dissociation step are found to be very fast. The first five studies are all carried out in one particular ionic liquid, and the reactions and mechanisms are compared to that observed in conventional aprotic solvents. The last three studies employ several RTILs with different cations and anions to look at the contrasting interaction of protons with the RTIL cation/anion and ultimately help to understand the pH properties of the solvent. The overall findings from the work in this thesis are that some reactions and mechanisms (e.g bromide, nitro derivatives and ammonia) are generally the same in RTILs as in conventional aprotic solvents, but other species (e.g. nitrates, phosphorus derivatives) show remarkably different behaviour. It has also been demonstrated that RTILs are suitable media for the detection of nitrogen dioxide, hydrogen and ammonia gases. This suggests that RTILs could potentially offer many advantages when employed as solvents in electrochemical reactions and in amperometric gas sensors.
7
Markwica, Robin. "The passions of power politics : how emotions influence coercive diplomacy." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f0c5b87d-f11c-4c61-bd8a-35feb7b56078.
Повний текст джерелаАнотація:
In coercive diplomacy, actors employ the threat of force to get targets to change their behavior. The goal is to achieve the opponent's compliance without waging war. In practice, however, the strategy often falls short-even when coercers enjoy substantial military superiority. This finding inspires the central question of this thesis: What prompts leaders to reject coercive threats from stronger adversaries, and under what conditions do they yield? I argue that target leaders' affective reactions can help to explain why coercive diplomacy succeeds in some cases but not in others. Combining insights from psychology and social constructivism, this thesis presents a theory of emotional choice to analyze how affect enters into target leaders' decision-making. Specifically, it makes the case that preferences are not only socially but also emotionally constructed. The core of the theoretical framework outlines how five key emotions-fear, anger, hope, pride, and humiliation-help to constitute target leaders' preferences. This represents the first attempt to explore how a spectrum of emotions influences leaders' foreign policy decision-making. To test the analytic utility of emotional choice theory, the thesis examines nine major decisions by Nikita Khrushchev during the Cuban missile crisis in 1962 and ten main decisions by Saddam Hussein in the course of the Gulf conflict in 1990-91. The analysis yields mixed results: In the case of about a third of all decisions, the five key emotions exerted only minor effects or no impact at all. Another third of the decisions were influenced by one or more of these emotions to a degree similar to the impact of other factors. In the case of the final third of decisions, however, some of these emotions became the primary forces shaping the construction of preferences. Overall, emotional choice theory has thus advanced our understanding of the target leaders' decision-making in the missile crisis and the Gulf conflict, offering a more comprehensive explanation of why coercive diplomacy succeeded in one case but not in the other.
8
Dalung, Emma, and Mikael Johansson. "Kvalitetssäkring av monteringsmoment vid Fasta Motorers F11-montering utifrån en process-, felläges- och effektanalys." Thesis, Högskolan Väst, Institutionen för ingenjörsvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-4257.
Повний текст джерелаАнотація:
I detta examensarbete har möjligheten att kvalitetssäkra en monteringsbana vid Parker Hannifin Manufacturing Sweden AB:s anläggning i Trollhättan utretts. Syftet med studien var att förbättra kvalitetssäkringen vid Fasta Motorers F11-montering och arbetet baserades på en tidigare utarbetad felläges- och effektanalys. För att styrka kundperspektivet genomfördes en undersökning av vad kunderna reklamerar, i form av PQP-anmälningar samt NCMR-rapporter. Genom att därefter identifiera kritiska monteringsmoment i felläges- och effektanalysen, PQP-anmälningar och NCMR-rapporter, var en prioritering möjlig att utföra. Prioriteringen resulterade i att feltyperna felvridet lagerhus, felplock av material samt kuggfel ansågs vara de mest kritiska att kvalitetssäkra. Målet med arbetet var att reducera det totala risktalsvärdet, vilket var möjligt genom en konceptgenerering samt ett konceptval för de specifika prioriteringarna. I samband med konceptgenereringen undersöktes, genom intervjuer med berörd personal, specifika kundbehov. Dessa kundbehov omarbetades därefter till målspecifikationer för att underlätta genereringen av koncept. Då informativa koncept var framtagna återstod ett val av det bäst lämpade konceptet. Valet utfördes med två olika metoder, screening och scoring samt 3P, för att ytterligare säkerställa att rätt koncept valts. Det var därmed möjligt att uppdatera felläges- och effektanalysen med de valda åtgärderna och då påvisa att syftet var uppnått. Syftet med kvalitetssäkringen uppnåddes genom att sänka det totala risktalsvärdet med 47,5 procent mot det tidigare risktalsvärdet, 6415.<br>In this thesis an investigation has been made in order to find possibilities to assure the quality at an assembly line at Parker Hannifin Manufacturing Sweden AB:s facility in Trollhättan. The purpose with the study was to improve the quality assurance at Fixed Motors F11-assembly line, where the work was based on an already conducted process-FMEA. In order to verify and further investigate the customer perspective, an inquiry was also done to see what customers complained about, this with help of PQP, Product Quality Problems, and NCMR, Nonconformance reports. By analyzing the process-FMEA, PQP and NCMR reports an identification and prioritization of critical failures were made. The result from these steps was three failures, incorrect positioning of the bearing house, picking of incorrect material and incorrect gear timing. These three were considered to be the most critical failures to quality assure. The aim with the quality work were set to reduce the total RPN, Risk Priority Number, of the process-FMEA, which was rendered by applying a concept generation and a concept selection for the specific failures. In relation with the concept selection, interviews were made with staff that was considered important and vital for the project. This was made to identify specific customer needs regarding solutions to the three failures. From these needs a target specification was developed to ease the generation of concepts. After generating a number of well specified concepts, a concept selection was made using the two methods screening and scoring and an additional Parker method called 3P to further establish that the right concepts was chosen. Further it was then possible to update the process-FMEA with the chosen concept solutions and by doing that reaching the project aim. By implementing the solutions it was possible to reduce total RPN, 6415, with 47,5 percent.
9
Jovanovic, Milan. "Structure-function relationships in the protein subunit of bacterial ribonuclease P." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1092422670.
Повний текст джерелаАнотація:
Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 287 p.; also includes graphics (some col.). Includes bibliographical references (p. 282-287). Available online via OhioLINK's ETD Center
10
Griffin, Sean James. "A systems engineering design of a retirement for cause life management process for life-limited F110-GE-400 engine parts." Master's thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-03172010-020231/.
Повний текст джерела
11
Kliafa, Maria. "An investigation of bioremediation for the conservation of petroleum-contaminated stone monuments." Thesis, De Montfort University, 2005. http://eprints.lincoln.ac.uk/5105/.
Повний текст джерелаАнотація:
Today, great effort is made for the protection of cultural heritage. Natural or anthropogenic factors decrease the conservation condition of the cultural artefacts, while their protection and survival mainly depends on political, financial, and technological issues. This project concerns the influence of the environmental pollution on cultural heritage and focuses on the potential effect of chronic petroleum hydrocarbon ground leakage on the subterranean parts of stone monuments. Bibliographic research revealed that there are many references to the effect of air pollution on building stone. However, research has not been expanded to the field of underground pollution in relation to the condition of the stone. Thus, the sources of petroleum pollution are presented, the paths of migration to the monument, the physical phenomena concerning the entrance of such pollution into the pores of the stone, as well as its potential movement in the porous net. The main effort was to assess the protection of a monument subjected to chronic petroleum pollution, by reducing the pollutant content of the stone. The existing methodologies on the reduction of hydrocarbon content in soil and groundwater were assessed, and criteria were set for a remediation method applicable to the treatment of the foundations of stone monuments. The method identified as most appropriate was bioventing, which is the use of air to stimulate indigenous microorganisms that have the ability to transform petroleum hydrocarbons into harmless by-products. Three types of limestone (grey-, marly-, and sandy-) were shown to be significantly weakened by a non-immiscible mixture of water and petroleum hydrocarbons when present in the pores of the stone. The bioventing treatment was shown to reduce the hydrocarbon content of the stone by 75% after a 60 day treatment. The rate of biodegradation achieved was 30 times higher than when no treatment was administered. Recommendations on future management and conservation policies of stone monuments are given.
12
Fatemian, Marzieh. "Coulomb excitation and break up." Thesis, University of Oxford, 1988. http://ora.ox.ac.uk/objects/uuid:65ba4b2b-f1ea-462d-a652-742113eb11ea.
Повний текст джерелаАнотація:
Break up processes involving a three body system in the Coulomb field are studied. A method is developed for the realistic treatment of such a system, and is applied to the break up of the nucleus, <sup>7</sup>Li. The Simple Cluster Model of <sup>7</sup>Li and the Coulomb excitation code COULVAR are used for the calculations. The continuum states of the α + t system are treated as a set of discrete states, by confining the relative motion of the clusters to a spherical box. The infinite set of states is then truncated by imposing an energy cutoff so that only the states below this energy are considered. The density of these states varies according to the box radius and the energy cutoff. The stability of the model is tested by varying these two parameters. The corresponding calculated probability of excitation of <sup>7</sup>Li has converged for a box radius of 20 fm and an energy cutoff of 20 MeV. The level energies and the wavefunctions of the continuum states are then easily obtained and are used to calculate the important matrix elements for the electromagnetic transitions between the bound states and the continuum states of <sup>7</sup>Li. The method is used to calculate the probability of excitation of <sup>7</sup>Li to its first excited state in the inelastic scattering experiments. It successfully reproduces a range of available data. An approximation is then developed to calculate the nuclear-Coulomb interference at low energies (well below the Coulomb barrier). The results of its application supports the need for renormalisation of the nuclear potentials suggested by inverse scattering calculations. The method closely reproduces The <sup>7</sup>Li data in this region with the refitted nuclear potentials. The application of the three body model to the break up of <sup>7</sup>Li on heavy targets at high energies produces very interesting results. It predicts reasonably good cross sections in the regions of pure Coulomb interaction. It also shows that at high energies the nuclear forces become very strong and affect the classical Rutherford orbit of the projectile. These effects are enhanced for heavier targets and the observed small scattering angle should not be taken as the angle of a classical orbit. Finally improvements towards the generalisation of the method are suggested so that it will be capable of coping with any three body system in a strong Coulomb field.
13
Livingstone, Sonia M. "Social knowledge and programme structure in representations of television characters." Thesis, University of Oxford, 1987. http://ora.ox.ac.uk/objects/uuid:2adf1878-f117-4c32-870c-9d0ec539bb11.
Повний текст джерелаАнотація:
It was argued that the social psychology of person perception, mass communications and cultural studies can be related to viewers' representations of television characters. Mass communications needs to incorporate viewers' interpretations and programme structure. Social cognition could satisfy the former need and cultural studies the latter. A literature review showed little research on viewers' interpretations of television programmes. There is a considerable body of research on person perception, gender stereotypes, the effects of viewing and programme structure. A study of viewers' accounts of viewing soap opera showed that they become involved with the characters and find the programmes realistic. Soap opera plays an important role in their lives. Viewers' representations of soap opera characters were examined using multidimensional scaling. This revealed stable, replicable character representations for Dallas, Coronation Street and EastEnders. The representations were compared with the oppositions which structure the programmes, Implicit Personality Theory and Gender Schema Theory. Dallas characters were represented by themes of morality and power/activity. Power was correlated with gender, with some counter-stereotypic females. Coronation Street characters were organised around morality/potency, gender (matriarchal) and approach to life. This related to person prototypes and contrasted with interaction patterns between characters. EastEnders characters were represented by themes of morality/power, gender and approach to life/centrality. Free descriptions validated the attribute ratings and showed further features of the representation. No socio-structural group differences in representation were found. Viewers' character representations were a constructive integration of programme structure and social knowledge. The application of abstract knowledge to a structured domain was discussed. Textual analysis of a narrative identified the 'role of the reader' and textual openness. This was related to stereotypes, narrative expectancies, myth and character representation. Distinct types of divergence in viewers' interpretations of narrative were discovered. Further, a narrative containing two readings was interpreted in four distinct ways by viewers, depending on their perceived relationships with characters. The conclusions and limitations of the research were discussed. Implications for person perception, stereotyping and textual analysis were examined. A taxonomy of factors relating to the interpretation and representation of television drama was presented.
14
Stos-Gale, Zofia. "Application of lead isotope analysis to provenance studies in archaeology." Thesis, University of Oxford, 1992. http://ora.ox.ac.uk/objects/uuid:38e670cf-f1fa-4c6d-8c5e-e2d7ca4fdbfa.
Повний текст джерелаАнотація:
Advances in mass spectrometry in the second half of this century allowed very accurate measurements of isotopic compositions of various elements. In turn it was discovered that due to the radiogenic origin of some of these isotopes their composition often reflects the geochemical history of minerals and rocks. Terrestrial lead is composed of four isotopes, of which three are radiogenic in origin as daughters of uranium and thorium. In geochronology the isotopic composition of minerals helps in dating the ore and rock formations. However, if there is enough diversity amongst the isotopic compositions of different deposits, then their lead isotope composition can be used as a simple and unique 'fingerprint', which can be scientifically measured. This feature can be used as a powerful tool in the identification of sources of ancient metals, because it passes unchanged through the smelting and refining processes. However, one of the most important requirements for such 'lead isotope provenance studies' is empirical investigation of the 'fingerprints' of ore deposits which are relevant to a given archaeological research. In this dissertation the scientific foundations of lead isotope provenance studies are described and examined in detail. All available evidence concerning the possibility of distinguishing isotopically between different European ore deposits is examined and methods of visual and numerical evaluation of the lead isotope data are suggested. Two examples of applications to specific archaeological problems are also given: the identification of sources of metals used for production of Bronze Age Cretan weapons and of non-ferrous metals in the Roman Period in Southern Poland. The interpretation of lead isotope data for archaeological objects is based on nearly 1500 isotopic analyses of ores.
15
Guáqueta, Alexandria. "Change and continuity in United States-Colombian relations, during the war against drugs, 1970-1998." Thesis, University of Oxford, 2002. http://ora.ox.ac.uk/objects/uuid:9cb3fb07-f14a-4337-9d8f-98272021d6ec.
Повний текст джерелаАнотація:
This thesis addresses almost three decades of U.S.-Colombian relations and asks two main questions. Why did relations remain friendly for so long given the many problems associated with drugs, and the notion that drugs and drug trafficking constituted a security problem? And what changed in 1995 so as to alter the course of friendship? It argues that U.S. and Colombian preferences over illegal drug control policy have not always been at odds, and disagreements have not precluded cooperation and joint action on drug control matters over a significant period of time. Nor can power asymmetry, a constant feature in the relationship, account for change. A successful account of both friendship and antagonism can be given only by spelling out the ideational and normative components that have contributed to define the character of the relationship and to determine the attitudes and behaviour towards each other. These components refer to the understandings of the drug problem, ideas on what constitutes mutually acceptable political and economic behaviour and their underlying norms, and the images that relevant policy-makers have of each country. This thesis also underscores the need to take stock of the cumulative process by which Colombia and the United States embraced and expanded drug prohibition.
16
Cook, Nicola. "Population genetics of the farmland sawfly Dolerus aeneus (Hymenoptera, Symphyta)." Thesis, University of Dundee, 2011. https://discovery.dundee.ac.uk/en/studentTheses/c1f5eccc-f116-452c-a7a9-460806fd7a09.
Повний текст джерелаАнотація:
Over the last 50 years populations of certain farmland birds have undergone severe declines over the same timescale that agriculture has intensified. The larvae of grassland sawflies (Hymenoptera, Symphyta) are a key component of the fledgling diet and it is thought that agri-intensification has reduced the numbers of these insects to such an extent that the populations of bird species dependent on them are limited. Sawfly populations may be more than usually susceptible to disturbance because firstly, their adult stages are poor dispersers and secondly, some species possess Complementary Sex Determination (CSD), a mechanism which can produce sterile males under inbreeding conditions. This study has produced a sawfly transcriptomic library through the use of 454 pyrosequencing, the first genetic resource for any farmland sawfly. From this library, a set of 13 polymorphic microsatellite markers were isolated for use in the common farmland sawfly Dolerus aeneus. Using these markers, three Scottish populations of D. aeneus, a species common to all six UK sites sampled in this study, exhibited similar levels of genetic diversity and low levels of genetic differentiation. However, evidence of inbreeding was detected in each of the three populations. In addition, potential diploid males were detected in D. aeneus using microsatellite markers, a primary indication that CSD may be operating in this species. The population genetic analysis in the current study suggests that fragmentation of suitable sawfly habitat as a result of agricultural intensification has not yet acted to isolate D. aeneus populations, although some genetic effects (inbreeding and low diversity compared with non-threatened hymenopterans) are apparent. In addition, diploid males have been detected which may have compromised fertility. This study will be of interest to research groups working on the genetics of the Hymenoptera and on the conservation and management of sawflies and the bird species dependent on them.
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Straker, Robert N. "Higher-order cycloisomerisations of enynamides." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:07677f16-f1ea-443e-b9dd-6239963d3ec4.
Повний текст джерелаАнотація:
This thesis describes the development of a novel transformation of ynamides, and addresses more general questions of asymmetric cycloisomerisation. The rhodiumcatalysed [5+2] cycloisomerisation of ynamide vinylcyclopropanes A1 to [5.3.0]- heterobicycles A2 is established (Scheme i). We design a versatile substrate synthesis, which allows the preparation of diversely substituted enynamide substrates. Under achiral rhodium catalysis, the extent of substrate diastereo- and regioselectivity is investigated. The reaction is rendered asymmetric with the use of chiral phosphoramidite ligands; where a mechanistic hypothesis for stereoselectivity leads to the development of a powerful catalyst system for the preparation of enantioenriched A3. A theoretical reaction analysis elucidates the mechanistic pathway, and gives an energetic rationale for our model of ligand stereoinduction. Our asymmetric catalyst system is applied to the [5+2] cycloisomerisation of chiral substrates in double stereodifferentiating transformations, where it is possible to synthesise previously inaccessible diastereomers of product A4.
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Thacker, Deborah Cogan. "An examination of children's inter-action with fiction, leading to the development of methodologies to elicit and communicate their responses." Thesis, Coventry University, 1996. http://curve.coventry.ac.uk/open/items/02f45a95-b816-3c19-f111-bcb0ce6fab4b/1.
Повний текст джерелаАнотація:
This thesis provides an examination and analysis of the social contexts of children's response to fiction in order to contribute to a theoretical perspective of literary response as a continuous process. The absence of a consideration of the way that readers are socially constructed renders any conception of literary response incomplete, and a discussion of textual, psychoanalytic and cultural theories of response reveals a gap which Children's Literature must fill. The marginalisation of Children's Literature within literary discourses silences children as readers by denying the recognition of literary engagement inherent in early experiences with fiction. In addition, an investigation of the meta-discourse which surrounds Children's Literature, through criticism, education and provision, demonstrates the way that adult mediations between children and fiction frequently interrupt an innate desire for an authoritative position for the reader within the text, replacing dynamic creative engagement with static modes of reading. In particular, an analysis of the position of children's books, including the processes for editing, selection and marketing, makes it clear, for the first time, that the social contexts of children's fiction, from jacket design to library selection, influence the construction of readers. A new method of empirical research, based on psychoanalysis, phenomenography and Chambers's 'Tell Me' approach to booktalk, provides evidence of the interplay of desire and control in the social construction of readers and reinforces the need for shared discourses. This method is illustrated by the Book Choice Study, consisting of seven individual case studies with children, their parents and teachers, which reveals the importance of an individual's reading history in the promotion of either dynamic or static modes of reading. The study shows that children who engage in a shared discourse about fiction are more likely to participate in a 'literary' engagement than those who experience a divided discourse, confirming the need for a construction of response that includes children and their books.
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Burns, Ethel. "Intrapartum birthing pool use in the UK." Thesis, Oxford Brookes University, 2014. https://radar.brookes.ac.uk/radar/items/5d0136b3-f1fa-4956-9e11-3d39261a279a/1/.
Повний текст джерелаАнотація:
Over past centuries, childbirth has become increasingly medicalised, with a shift to hospital births and an overuse of interventions for women at low risk of childbirth complication. In response, there has been a move towards normalising birth which has grown in strength over recent years. In this thesis, I describe a programme of research which aimed to examine whether intrapartum birthing pool use could make an important contribution to normalising childbirth for low risk women. Maternity stakeholders differ in their views of intrapartum birthing pool use, with some emphasising its potential to reduce interventions and increase spontaneous birth and others raising concerns that birthing pool use, particularly waterbirth, predisposes women and their newborn to an increased risk of adverse events and outcomes The focus of my programme of research was therefore on examining the efficacy and safety of intrapartum birthing pool use, and its potential contribution to normalising childbirth for healthy women. In the first stage of my research programme, I analysed prospectively collected data for 8,924 nulliparous and multiparous women who used a birthing pool during labour in their planned place of birth. In the second stage ̧ I explored the possibility of comparing intrapartum interventions and outcomes for women who used a birthing pool and women who could have, but chose not to use a birthing pool in one obstetric unit. Having found the unit was not representative of other obstetric units, in the third stage I used a bespoke dataset comprising routinely collected maternity data collated by Hospital Episode Statistics (HES) as a comparator for the birthing pool data. This research found that, for the birthing pool sample, adverse maternal and newborn outcomes were rare, and there were no differences in interventions and outcomes between care settings for multiparae or newborn. Comparisons with HES data showed significantly more birthing pool women had a spontaneous birth. This allays concerns over safety and supports the conclusion that intrapartum birthing pool use can make an important contribution to normalising birth.
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Faber, Helen. "Individualité." Master's thesis, Université Laval, 2001. http://hdl.handle.net/20.500.11794/33854.
Повний текст джерелаАнотація:
Tableau d’honneur de la Faculté des études supérieures et postdoctorales, 2001-2002<br>Les moyens technologiques ont suscité différents phénomènes qui ont eu une influence sur la pratique de l’illustration de mode. Le vêtement est défini comme langage indiquant comment il tient un rôle déterminant dans un discours social, comme une véritable carte d’identité. Sortis de leur contexte le vêtement et l’art contemporain ont des pluralités et des singularités qui les font se rapprocher et se nourrir mutuellement. Le vêtement questionné dans un milieu de mode organisé nous fait mieux comprendre le rôle de l’illustrateur de mode. L’histoire de l’illustration de mode nous explique la réciprocité de l’art et de la mode comme facteur d’évolution, à tel point qu’aujourd’hui ces genres se nourrissent mutuellement. L’art donne des habits neufs à la mode, le vêtement questionne l’art dans ses sujets de prédilection : le corps, les attitudes, les comportements, les valeurs, et l’identité. Ma démarche en création vise à établir une complicité entre un discours scientifique, sociologique et artistique sur les aspects du vêtement et de la mode. Elle questionne le potentiel artistique de l’illustration de mode soustrait de sa fonction et mise en espace par l’installation dans le lieu de la galerie d’art.<br>Québec Université Laval, Bibliothèque 2019
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Jame, Shadi. "Le régime de la nationalité en droit syrien et en droit français : étude de droit comparé entre domination coloniale et droit international contemporain." Nantes, 2010. https://archive.bu.univ-nantes.fr/pollux/show/show?id=5e79d3da-f17a-45c4-9f09-c061d198569a.
Повний текст джерелаАнотація:
La nationalité est considérée comme un lien politique et juridique entre l’individu et l'État. La nationalité est très importante pour la vie de la personne, pour l'État et pour la communauté internationale. En effet, pour la vie de la personne, la nationalité détermine l’état politique (les droits civiques) et la distingue de l’étranger. L’article 15 de la Déclaration Universelle des Droits de l’Homme de 1948 énonce que « tout individu a droit à une nationalité », un droit principal rattaché à l’individu dans sa vie personnelle : sans nationalité la personne ne peut acquérir les droits essentiels de la vie. Le monde d’aujourd’hui est de plus en plus globalisé, dans lequel les sociétés contemporaines interagissent facilement et d’une façon continue. Dans ce contexte, le droit comparé permet de mieux comprendre les questions liées à la nationalité, et plus particulièrement de traiter des problèmes comme la nationalité des enfants, l’égalité hommes-femmes, la double nationalité et celui de l’apatridie. Cette thèse propose une étude de droit comparé entre les droits français et syrien de la nationalité. Elle met en évidence l’influence exercée par le droit français sur le droit syrien notamment pendant le mandat français sur la Syrie (de 1924 à 1951) et les contraintes du droit international sur le droit syrien. Le droit syrien de la nationalité n’ayant pas évolué depuis 1969, cette étude entend proposer plusieurs directions pour lui permettre d’évoluer dans un sens plus conforme à l'évolution de la société syrienne<br>The nationality is considered as the political and legal bond between the individual and the State. It is very important for the life of the individual, the State and the international community. In fact, the nationality determines the political status of the individuals (the civil rights) along their life and distinguishes them from the foreigners. The Article 15 of the Universal Declaration of Human Rights 1948 states that "everyone has the right to have a nationality" a principal right attached to the individual in his personal life: without having this nationality he will not be able to acquire his essential rights of life. Today’s world is increasingly globalized where the contemporary societies interact easily and continuously. In this context comparative law makes it possible to better understand the issues relating to nationality, and more particularly to deal with the issues such as the nationality of children, equality between men and women, dual nationality and that of statelessness. This thesis deals with a study of comparative law between the French and Syrian nationality law. It underlines the influence of French law on the Syrian law in particular during the French mandate in Syria (from 1924 to 1951) and the constraints of international law. Syrian law of nationality has not changed since 1969. This study intends to propose several directions to allow this law to evolve in a more consistent way
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Koch, Doreen [Verfasser], H. [Akademischer Betreuer] Nies, G. R. [Akademischer Betreuer] Sawers, and K. [Akademischer Betreuer] Hantke. "Charakterisierung eines neuen, zweiteiligen Eisenaufnahmesystems aus dem uropathogenen Escherichia coli Stamm F11 / Doreen Koch. Betreuer: H. Nies ; G. R. Sawers ; K. Hantke." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2011. http://d-nb.info/102523118X/34.
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O'Connell, Kelleen. "Edmund Burke : religion and eighteenth-century modernity." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/edmund-burke(0c163e56-f1aa-4c0e-9204-e43702b04f7d).html.
Повний текст джерелаАнотація:
This thesis fills the need for a comprehensive study of Edmund Burke’s representation of global religions throughout the general oeuvre of his writings and speeches. My objective is to advance the study of Burke by offering a critical account of his religious thought, as a critical imprint in his literature. In addition to situating Burke’s writing in the context of Enlightenment thought and eighteenth-century public life, I make a further contribution to the study of Burke’s literature by demonstrating how twentieth and twenty-first century theories of modernity can help to articulate Burke’s conception of religion. Studies that have categorically seated Burke in the context of ‘modernity’ (for example, from Terry Eagleton, Paddy Bullard, and Stephen K. White) treat him as a ‘politician’, as ‘Edmund Burke the rhetorician’, or ‘as an aesthetician’.1 My thesis compliments these studies by filling the need to treat Burke as a multicultural quasi-religious thinker in the context of modernity. Studies that have treated Burke in a religious context (for example, from Conor Cruise O’Brien, Thomas H.D. Mahoney, Eamonn O’Flaherty, Elizabeth Lambert, J.C.D. Clark, Brian Young, Frederick Dryer, and others) have done so with the objective of understanding more about his personal religious convictions.2 Differing from such studies, I do not intend to unearth Burke’s true religious identity; rather, I intend to fill the need for a full-length study of Burke’s analysis of religion, as it appears in a literary context. There exists no monographic study of Burke’s conceptualization of global religions as translated through recent theories of modernity. This is the task set forth in this thesis. Most of the studies that acknowledge Burke in a religious context treat him in strictly Christ-centred terms, mostly to support reactionary-conservative interpretations (e.g., Francis Canavan, Bruce Frohnen, and Christopher Hitchens).3 I wish to examine political thinking about religion, beyond Christ-centred terms - his global conception of non-Christian, non-god-centred thinking. In doing so, this thesis is intended to present an interpretation of Burke that acknowledges the importance he placed on indigenous religious culture. To my mind, interpretations of Burke that emphasise his reactionary-conservatism also implicate him as being anti-modern. As I intend to explore Burke’s writings and speeches in the context of modernity, I believe it is only responsible to acknowledge these interpretations of him as a reactionary-conservative. I use the work of J.G.A. Pocock, S.J. Barnett, Bruno Latour and others to establish a context of eighteenth-century modernity, or what was modern to Enlightenment minds.4 In addition, my critical analysis of Burke demonstrates how the same characteristics and themes associated with this eighteenth-century context of modernity are reflected in representations of modernity that are more recent. I use twentieth and twenty-first century theories of modernity to enrich our understanding of Burke’s representation of religion. I deconstruct Burke’s representation of religion to suggest that it anticipates the various complexities communicated in studies of modernity (for example, from Zygmunt Bauman, Marshall Berman, and Paul Heelas, Phillip Blond, John Milbank, Jacques Derrida, and Michel Foucault).5 Ultimately, my thesis validates Burke as an originator of modern (and contemporary) religious conceptualization, which transcends things such as nation, sect, and even good and evil.
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Rapp, Vera Christin [Verfasser], and Meinrad [Akademischer Betreuer] Gawaz. "Der funktionelle Effekt und die Signifikanz der homophilen Interaktion zwischen dem löslichen Junctional Adhesion Molecule A und dem F11 Rezeptor auf der Thrombozytenoberfläche / Vera Christin Rapp ; Betreuer: Meinrad Gawaz." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1201644992/34.
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Rapp, Vera [Verfasser], and Meinrad [Akademischer Betreuer] Gawaz. "Der funktionelle Effekt und die Signifikanz der homophilen Interaktion zwischen dem löslichen Junctional Adhesion Molecule A und dem F11 Rezeptor auf der Thrombozytenoberfläche / Vera Christin Rapp ; Betreuer: Meinrad Gawaz." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1201644992/34.
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Breuss, Fritz. "Balassa-Samuelson effects in the CEEC. Are they obstacles for joining the EMU?" Forschungsinstitut für Europafragen, WU Vienna University of Economics and Business, 2003. http://epub.wu.ac.at/198/1/document.pdf.
Повний текст джерелаАнотація:
A phantom is haunting the EU enlargement process. Some fear that the Balassa-Samuelson (B-S) effect might be a major obstacle for the Central and Eastern European countries (CEEC) to become members of the Economic and Monetary Union (EMU). A review of the relevant literature reveals that most estimations of the B-S effect in the EU acceding countries are flawed by one kind or the other. Either they do not estimate correctly the B-S propositions, or if they measure it they use a variety of measures for the variables needed. Additionally, the B-S effect is only a special case of a broader approach towards equilibrium real exchange rates. Lastly the B-S effect is studied in a CGE multi-country world in order to detect possible spillover effects. After describing the "official" road map towards the EMU, it is concluded that the uncertainties in measuring the B-S are much too high in order to see in it (alone) a major hindrance for the CEEC to become early members of the EMU. Moreover, real exchange rate appreciations that reflect productivity gains in the tradable sector are an equilibrium phenomenon and do not require a policy response. They are a natural phenomena in catching-up countries like the CEEC. Furthermore, the official doctrine for entering the EMU by the EU/ECB only interdicts depreciations but not appreciations for potential EMU members. (author's abstract)<br>Series: EI Working Papers / Europainstitut
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Griffiths, Mark. "Research towards a better future : neoliberalism, global citizenship and international volunteering." Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/research-towards-a-better-future(fc7114bd-f11d-4d47-bbf1-fb2c6ebaff7f).html.
Повний текст джерелаАнотація:
This thesis discusses the British government’s construction of global citizenship on its recently launched (2011) International Citizen Service (ICS) programme that sends volunteers abroad to work on international development projects. The thesis has two objectives. The first is to understand global citizenship on the ICS programme as it takes shape in a climate of neoliberal policy making. The second is to produce a piece of ‘socially engaged’ research that looks towards a better future. The thesis unfolds as an account of global citizenship as it is produced through the discursive rationalities and circulated affects that have come to define contemporary modes of neoliberal governance. This part of the discussion argues that through ICS the government constructs a markedly neoliberalised version of global citizenship, based on “soft” understandings of development and a heavy emphasis on self-advancement. The inquiry then moves on to consider research performances and how best to conceptualise the relationship between power and people. The case is made that power-centric accounts can reinforce the dominance of power and consequently ‘a better future’ in research might explore the aspects of social life that do not defer to expressions of power. Taking this position to ethnographic data collected from ICS project sites in India the thesis then examines the ways that volunteers contest, subvert and resist the government’s version of global citizenship. As a response to the earlier exploration of rationalities and affects, the presentation of the data illustrates the ways that volunteers on the one hand critically engage with development issues while on the other establish strong affective relationships with host communities. Together, these perspectives show volunteers capable of resisting neoliberal iterations of global citizenship. Instead, the volunteers on the ICS programme practice creative and affective interpretations of global citizenship that, in important ways, transcend the impositions of power and, in so doing, look towards a better future.
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Krisztin, Tamás, and Manfred M. Fischer. "The gravity model for international trade: Specification and estimation issues in the prevalence of zero flows." WU Vienna University of Economics and Business, 2014. http://epub.wu.ac.at/4453/3/TheGravityModelForInternationalTrade2.pdf.
Повний текст джерелаАнотація:
The gravity model for international trade is one of the most
successful empirical models in trade literature. There is a long tradition to log-linearise the multiplicative model and to estimate the parameters of interest by least squares. But this practice is inappropriate for several reasons. First of all, bilateral trade flows are frequently zero and disregarding countries that do not trade with each other produces biased results. Second, log-linearisation in the presence of heteroscedasticity leads to inconsistent estimates in general.
In recent years, the Poisson gravity model along with pseudo maximum likelihood estimation methods have become popular as a way of dealing with such econometric issues as arise when dealing with origin-destination
flows. But the standard Poisson model specification
is vulnerable to problems of overdispersion and excess zero
flows. To overcome these problems, this paper presents zero-inflated extensions of the Poisson and negative binomial specifications as viable alternatives to both the log-linear and the standard Poisson specifications of
the gravity model. The performance of the alternative model specifications is assessed on a real world example, where more than half of country-level trade flows are zero. (authors' abstract)<br>Series: Working Papers in Regional Science
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Rankin, Alexandra Catherine. "Pro-fibrotic effects of all-trans retinoic acid in transforming growth factor-β1-induced fibrogenesis in renal fibroblasts". Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/profibrotic-effects-of-alltrans-retinoic-acid-in-transforming-growth-factor1induced-fibrogenesis-in-renal-fibroblasts(6778e905-f1a1-4cd5-a911-5b59dd6906b8).html.
Повний текст джерелаАнотація:
Retinoids, including the prototypic vitamin A and its main bioactive form, alltrans retinoic acid (tRA), have both anti- and pro-fibrotic effects in renal disease models. To understand and prevent the pro-fibrotic effects of retinoids it is important to establish in vitro models. This work aimed to explore the mechanisms behind the fibrogenic effects of tRA in renal fibroblasts. A picro-Sirius red-based in vitro assay was used to determine the effects of retinoids on total collagen accumulation with and without transforming growth factor (TGF)-β1 in NRK-49F normal rat kidney fibroblasts. Individual fibrotic markers and nuclear receptors were investigated using molecular biology approaches, activity assays and chemical agonists and inhibitors. tRA dose-dependently increased total collagen deposition with and without TGF-β1 in NRK-49F cells. At the level of gene expression tRA showed dual potential, down-regulating mRNAs encoding a range of extracellular matrix proteins and matrix metalloproteinases (MMPs), while up-regulating others including plasminogen activator inhibitor (PAI)-1 and transglutaminase 2 (TG2). tRA alone and additively, with TGF-β1, reduced MMP activity and increased PAI-1 protein; the PAI-1 inhibitor tiplaxtinin reduced the increase in total collagen caused by tRA and TGF-β1 treatment. TG2 protein was not modulated by tRA and a TG2 inhibitor did not reduce tRA’s pro-fibrotic effect. NRK-49F cells expressed retinoid nuclear receptors and PPARβ/δ and nuclear receptor mRNAs were differentially regulated by tRA and TGF-β1. RAR and RXR antagonists reduced tRA’s pro-fibrotic effect while a pan-RXR agonist more than a pan-RAR or PPARβ/δ agonist increased total collagen deposition. RAR isotype-selective agonists had less, if any, effect on fibrosis. In summary, an in vitro model for the pro-fibrotic effects of retinoids has been established, which is associated with modulation of MMPs, PAI-1 and RAR/ RXR. Further studies of RAR isotype-selective agonists might be of merit as they had reduced pro-fibrotic activities compared to less selective retinoids.
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Coxon, Thomas. "Functionalizing magnetite nanoparticles and vesicles with saccharide coatings for the targeting of cell surface lectins." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/functionalizing-magnetite-nanoparticles-and-vesicles-with-saccharide-coatings-for-the-targeting-of-cell-surface-lectins(3b8ce713-f117-46d5-bd98-1f4b21719f8a).html.
Повний текст джерелаАнотація:
The specific interaction between saccharide molecules and saccharide-binding proteins, lectins, can be exploited in order to actively target nanostructures to specific cell types for diagnostic or therapeutic purposes. However, the conjugation of saccharides to nanostructures can be complex, leading to a lack of versatility in the functionalities that can be achieved, or poorly characterized and therefore potentially inconsistent. Herein is reported a new procedure by which novel saccharide-containing molecules, for the functionalization of nanostructures, could be synthesized rapidly and with good yields. The synthesis was found to be versatile, providing coating molecules for magnetite nanoparticles and phospholipid vesicles from a number of different hydrazides and reducing sugars. The stability of the synthesized coating molecules was assessed, both in aqueous solution and when bound to the surface of a magnetite nanoparticle, and found to be satisfactory for cell culture purposes. The availability of the saccharide units for lectin binding was confirmed using a Quartz crystal microbalance (QCM-D) in addition to a number of assays. Finally, microscopy techniques were used to study the interactions between saccharide-functionalized magnetite nanoparticles and two cell types, fibroblasts (3T3) and hepatocytes (HepG2).This work demonstrated the ability of saccharide coatings to improve the uptake of nanostructures in a cell culture environment and highlighted the potential cell manipulation application of saccharide-coated magnetite nanoparticles.
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Riccardo, Gezzi. "Funktionale Renormierungsgruppe für Nichtgleichgewichtsphänomene in Vielteilchensysteme." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-000D-F11A-9.
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Fang, Tzu-Jung, and 方姿蓉. "F11R in Rheumatoid arthritis." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/60926344591254952638.
Повний текст джерелаАнотація:
碩士<br>高雄醫學大學<br>醫學研究所<br>99<br>Introduction: Rheumatoid arthritis is an autoimmune disease, which is affected by genetic and environmental factors. F11R is associated with inflammatory cells migration and also the target gene of aryl hydrocarbon receptor. The aryl hydrocarbon receptor is triggered by multiple environmental factors. F11R may link environmental factors to rheumatoid arthritis.
Aim: We investigate whether (1) F11R expression increases in rheumatoid arthritis? （2）F11R is associated with rheumatoid arthritis characteristics ? and（3）F11R is associated with inflammatory markers?
Material and Methods: We extracted RNA from peripheral blood mononuclear cells and DNA from peripheral blood in rheumatoid arthritis patients and control group. F11R mRNA expression was determined by real time PCR. SNP genotyping assay was done for single nucleotide polymorphism. IFN-γ was quantified by enzyme-link immunosorbent assay.
Results: F11R expression in peripheral blood mononuclear cells is more in rheumatoid arthritis patients than control group (p = 0.018). F11R expression is lower in patients who has impaired salivary gland function than control group (p= 0.037). F11R association with other secondary Sjögren’s syndrome characteristics is not significant. In F11R promoter -688 A＞C, C carrier possesses lower anti-CCP（p=0.002）and lacrimal gland problems(p=0.009). Both are significant after correcting DR4 existence. Different SNP genotype in F11R promoter -688 A＞C and -436 A>G doesn’t lead to different gene expression in rheumatoid arthritis patients. IFN-r amount in rheumatoid arthritis is not correlated with F11R.
Discussion: F11R’s role in inflammatory cell migration explains its higher expression in rheumatoid arthritis patients. The lower F11R expression in subgroup with impaired salivary gland function may be related with less intercellular junction expression. C carrier in F11R promoter -688 A＞C locus seems protective. The relation of IFN-γ and F11R in rheumatoid arthritis patients needs more studies to clarify.
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Shen, Yu-Wen, та 沈俞妏. "Characterization of the structure and aggregation behavior of Aβ40(L17A/F19A/D23N)". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/r9zsxr.
Повний текст джерелаАнотація:
碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>103<br>β-amyloid peptide (Aβ), which consists of 39-42 residues, is derived from proteolysis of β-amyloid precursor protein (APP). Aggregation of β-amyloid peptide (Aβ) is thought to be an early event in the pathogenesis of Alzheimer’s disease. The molecular mechanism underlying Aβ aggregation is not entirely understood. The process of Aβ aggregation into amyloid fibril involves conformational changes, suggesting that the conformational stability of Aβ play a key role in the aggregation process. Recently, we reported that L17A/F19A replacements could increase the conformational stability of wild-type Aβ40 and familial Alzheimer's disease-linked E22G variant of Aβ40 (Arctic Aβ40 variant), and reduce their α-helix-to-β-strand conversion and fibril formation rates. In this study, the effects of L17A/F19A replacements on the aggregation behavior and secondary structure propensity of D23N variant of Aβ40 (Iowa Aβ40 variant), which is also a familial Alzheimer's disease-linked variant of Aβ40, were characterized by using Nuclear Magnetic Resonance spectroscopy (NMR spectroscopy), Circular Dichroism spectroscopy (CD spectroscopy), Transmission Electron Microscopy (TEM) and Thioflavin T fluorescence assay. The results of kinetic aggregation studies indicated that L17A/F19A replacements can inhibit conformational changes and fibril formation of Aβ40(D23N). NMR structural studies revealed that L17A/F19A replacements mainly increased the α-helical propensity of the residues located in the α/β-discordant segment of Aβ40(D23N). These findings suggested that the α-helical propensity of the α/β-discordant segment is one key factor in governing the aggregation propensity of Aβ. This result may also provide a structural basis toward understanding the molecular mechanism of Aβ aggregation.
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Chaturvedi, Richa. "Tumor immunolocalization using iodine-124 radiolabeled monoclonal antibody JAA-F11." 2006. http://proquest.umi.com/pqdweb?did=1136096631&sid=15&Fmt=2&clientId=39334&RQT=309&VName=PQD.
Повний текст джерелаАнотація:
Thesis (M.S.)--State University of New York at Buffalo, 2006.<br>Title from PDF title page (viewed on Oct. 06, 2006) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Rittenhouse-Olson, Kate. Includes bibliographical references.
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Jadey, Snehal. "Structural characterization of JAA-F11-Fab by X-ray crystallography." 2007. http://proquest.umi.com/pqdweb?did=1397901711&sid=7&Fmt=2&clientId=39334&RQT=309&VName=PQD.
Повний текст джерелаАнотація:
Thesis (M.S.)--State University of New York at Buffalo, 2007.<br>Title from PDF title page (viewed on Mar. 06, 2008) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Olson, Kate R., Gulick, Andrew M. Includes bibliographical references.
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Yadav, Arti. "Immunolocalization in SCID mice bearing human tumor using iodine-124 radiolabeled monoclonal antibody JAA-F11." 2008. http://proquest.umi.com/pqdweb?did=1588770891&sid=3&Fmt=2&clientId=39334&RQT=309&VName=PQD.
Повний текст джерелаАнотація:
Thesis (M.S.)--State University of New York at Buffalo, 2008.<br>Title from PDF title page (viewed on Feb. 13, 2009) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Rittenhouse-Olson, Kate Includes bibliographical references.
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Hartmann, Rainer. "Deskription der Schwermetallgehalte in Knochen, Organen und Haaren von Fledermäusen (Chiroptera) im Zeitraum 1987 bis 1999." Doctoral thesis, 2001. http://hdl.handle.net/11858/00-1735-0000-000D-F10A-D.
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Mildner, Alexander. "Die Funktion der inflammatorischen CCR2+ Monozyten bei der postnatalen Mikrogliaentwicklung und bakteriellen Meningitis." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-000D-F110-E.
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Becker, Andreas. "Strengths and Difficulties Questionnaire (SDQ)." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-000D-F111-C.
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Schulz, Ramona. "Untersuchung des TGF-β-induzierten Zelltods in oligodendroglialen Kulturen". Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-000D-F112-A.
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Kalkan, Sinan. "Multi-modal Statistics of Local Image Structures and its Applications for Depth Prediction." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-000D-F113-8.
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Ofori, Atta. "Genetic diversity based on SSR markers, heterosis and yield performance of Brassica rapa for biomass production." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-000D-F114-6.
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Nath, Ujjal Kumar. "Increasing erucic acid content in the seed oil of rapeseed (Brassica napus L.) by combining selection for natural variation and transgenic approaches." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-000D-F115-4.
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Barua, Kamini Kusum. "Diversity and Habitat Selection of Papilionidae in a Protected Forest Reserve in Assam, Northeast India." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-000D-F116-2.
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Gorlovoy, Philipp. "Role of the microtubulin-associated molecule tau in inflammatory-mediated axonal damage." Doctoral thesis, 2007. http://hdl.handle.net/11858/00-1735-0000-000D-F118-D.
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Donkor, Fatima. "Interaktionen des testikulären outer dense fibre protein 2 (ODF 2)bei der zellulären Organisation." Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-000D-F119-B.
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Hub, Jochen Sebastian. "Selectivity, Regulation, and Inhibition of Aquaporin Channels. A Molecular Dynamics Study." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-000D-F11B-7.
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Schwier, Elke Ute. "Regulators of Ubiquitin Dependent Protein Degradation in the Filamentous Fungus Aspergillus nidulans: Insights into CsnB, DenA and CandA Function." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-000D-F11C-5.
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Fister, Stefanie. "Induktion von Apoptose in gynäkologischen Karzinomen in vitro und in vivo durch Antagonisten des Gonadotropin-Releasing Hormons Typ II." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-000D-F11D-3.
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Gibaud, Hélène. "Nahinfrarotspektroskopische Erfassung und Charakterisierung der nutritiven und fermentativen Qualität von Grassilage im ungetrockneten Zustand." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-000D-F11E-1.
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