Готові списки джерел за темами / Extracorporeal perfusion

Добірка наукової літератури з теми "Extracorporeal perfusion"

Автор: Grafiati

Опубліковано: 10 грудня 2022

Оновлено: 28 січня 2023

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Статті в журналах з теми "Extracorporeal perfusion"

&NA;. "EXTRACORPOREAL PERFUSION." ASAIO Journal 42, no. 2 (April 1996): 58–65. http://dx.doi.org/10.1097/00002480-199642020-00012.

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Cypel, Marcelo, and Shaf Keshavjee. "Extracorporeal lung perfusion." Current Opinion in Organ Transplantation 16, no. 5 (October 2011): 469–75. http://dx.doi.org/10.1097/mot.0b013e32834ab15a.

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McChesney, LP, EA Fagan, DL Rowell, JV Del Rio, F. Fabrega, M. Mills, and JW Williams. "Extracorporeal liver perfusion." Lancet 353, no. 9147 (January 1999): 120–21. http://dx.doi.org/10.1016/s0140-6736(05)76157-2.

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Hessheimer, Amelia J., Constantino Fondevila, and Juan C. García-Valdecasas. "Extracorporeal machine liver perfusion." Current Opinion in Organ Transplantation 17, no. 2 (April 2012): 143–47. http://dx.doi.org/10.1097/mot.0b013e328351082a.

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&NA;. "EXTRACORPOREAL PERFUSION/ECMO/ECCO2R." ASAIO Journal 43, no. 2 (March 1997): 29–36. http://dx.doi.org/10.1097/00002480-199743020-00007.

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Cypel, Marcelo, and Shaf Keshavjee. "Extracorporeal lung perfusion (ex-vivo lung perfusion)." Current Opinion in Organ Transplantation 21, no. 3 (June 2016): 329–35. http://dx.doi.org/10.1097/mot.0000000000000320.

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Neuhaus, P., and G. Blumhardt. "Extracorporeal Liver Perfusion: Applications of an Improved Model for Experimental Studies of the Liver." International Journal of Artificial Organs 16, no. 10 (October 1993): 729–39. http://dx.doi.org/10.1177/039139889301601010.

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Long-term extracorporeal liver perfusion of up to 24 hours was achieved with an improved model of pig liver perfusion. Functional and structural integrity of the extracorporeal liver was maintained during the entire duration of extracorporeal perfusion. After 24 hours SGOT was 33.5 (± 6.5) U/L, bile production was 11.5 ml/h. Survival of hepatectomized pigs could be extended to 18.9 (± 3.8) hours with extracorporeal liver perfusion (p < 0.01). The improvement of liver perfusion in our particular model is primarily based on optimised perfusion of the low pressure system of the portal and hepatic vein by the application of sinusoidal pressure profiles. These pressure profiles imitate intra-abdominal conditions and achieve homogeneous perfusion of the low pressure system of the portal vein and complete drainage of hepatic venous blood.

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Borel Rinkes, Inne H. M., Mehmet Toner, Ronald G. Tompkins, and Martin L. Yarmush. "An Extracorporeal Microscopy Perfusion Chamber for On-Line Studies of Environmental Effects on Cultured Hepatocytes." Journal of Biomechanical Engineering 116, no. 2 (May 1, 1994): 135–39. http://dx.doi.org/10.1115/1.2895711.

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The development of bioartificial-hybrid organ support systems is hampered by the lack of knowledge on the effects of different (in vivo) environments on cells during extracorporeal perfusion. In the present study, a perfusion chamber was designed for continuous monitoring of cultured cells during perfusion with media, as well as during plasma perfusion in an extracorporeal circuit. Chamber characterization showed satisfactory thermal and perfusion profiles and no major pH fluctuations. Further testing was performed with hepatocytes that were cultured in between two collagen layers, a configuration which was previously shown to preserve hepatocyte morphology and function for over six weeks of culture. Perfusion of the hepatocytes with culture media did not adversely affect cell morphology and function, provided the perfusion time was ≤ 48 hours. Perfusion of the cultures during connection of the chamber to an extracorporeal circuit involving normal rats for six hours resulted in reversible cytoplasmic changes, unaltered cell shapes indices, and a 40 percent increase in albumin secretion rate during the first post-perfusion day, followed by a return to stable control levels. We expect that this chamber will be a valuable tool for on-line studies of cells under (extracorporeal) perfusion conditions and could be used for a large variety of studies on regeneration, reperfusion damage, and detoxification.

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Ozturk, Muhammed Besir, Tolga Aksan, Ismail Bulent Ozcelik, Cengiz Ertekin, Bahadir Akcakoyunlu, Sidika Seyma Ozkanli, and Mustafa Tezcan. "Extracorporeal Free Flap Perfusion Using Extracorporeal Membrane Oxygenation Device." Annals of Plastic Surgery 83, no. 6 (December 2019): 702–8. http://dx.doi.org/10.1097/sap.0000000000002014.

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Ohira, Suguru, Masashi Kawamura, Kristin Ahern, Nicholas Cavarocchi, and Hitoshi Hirose. "Aggressive placement of distal limb perfusion catheter in venoarterial extracorporeal membrane oxygenation." International Journal of Artificial Organs 43, no. 12 (April 20, 2020): 796–802. http://dx.doi.org/10.1177/0391398820917160.

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Objective: The aim of this study is to review the impacts of aggressive placement of a distal perfusion catheter on the outcomes in patients supported with venoarterial extracorporeal membrane oxygenation via femoral cannulation. Methods: Analysis was performed with 143 consecutive femoral venoarterial extracorporeal membrane oxygenation cannulation. Patients were divided into two groups: the early period (October 2010 to December 2012, N = 47) where placement of a distal perfusion catheter was attempted percutaneously but not surgically and the late period (January 2013 to November 2018, N = 96) in which placement of distal perfusion catheter was aggressively utilized both percutaneously and surgically. The modification of venoarterial extracorporeal membrane oxygenation cannulation protocol for the late period involved (1) an immediate insertion of a distal perfusion catheter regardless of the size of femoral arterial cannula, (2) an open insertion of a distal perfusion catheter if percutaneous approach failed, and (3) when venoarterial extracorporeal membrane oxygenation cannulation was completed at a non-extracorporeal membrane oxygenation cannulation center, it was encouraged that they attempt insertion of a distal perfusion catheter at the time of cannulation. Results: In the late period, a distal perfusion catheter was placed in 96% (92/96) which was significantly increased from 66% (31/47) in the early period. Of these 92 patients in late period, nine patients (9.8%) required open direct insertion of a distal perfusion catheter. The incidence of lower limb ischemia (early vs. late period 26% vs 12%, P = 0.031) was significantly decreased in the late period. Logistic regression analyses showed that distal perfusion catheter placement was the only factor for preventing lower limb ischemia. Conclusion: Aggressive insertion of a distal perfusion catheter even utilizing surgical cut-down technique was shown to decrease the incidence of distal limb complications.

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Дисертації з теми "Extracorporeal perfusion"

Jonsson, Ove. "Cerebral Perfusion and Metabolism during Experimental Extracorporeal Circulation." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-147486.

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Neurologic injuries are major causes of mortality and morbidity after cardiac surgery. This thesis aimed to investigate cerebral metabolism and perfusion abnormalities in pigs during hypothermic circulatory arrest, selective antegrade cerebral perfusion (SACP) and extracorporeal circulation following progressive venous stasis. Hypothermic circulatory arrest induced a metabolic pattern consistent with overt ischaemia, which was absent following SACP. In contrast, metabolism during SACP was influenced by the perfusate temperature, where a colder perfusate (20 °C) preserved cellular metabolism and membrane integrity better than a warmer perfusate (28 °C). The minimum SACP flow required to maintain metabolism during hypothermia at 20 °C was investigated with magnetic resonance imaging, protein S100β, near infrared spectroscopy and microdialysis. The findings suggested an ischaemic threshold close to 6 ml/kg/min in the present models. Furthermore, regional differences in perfusion with a hemispheric distribution were apparent at all flow levels and differed from earlier studies where the differences were uniform and followed a neuranatomical pattern. Venus stasis following superior vena cava congestion produced measurable signs of impaired cerebral perfusion and patterns of cerebral ischaemia were evident in individual animals. As venous pressure increased, the mean arterial pressure stayed more or less unchanged, generating reduced cerebral perfusion pressure and consequently an increased risk of ischaemia, which may impair cerebral perfusion, especially in cases of compromised arterial flow during extracorporeal circulation. In conclusion, cerebral metabolism and perfusion are influenced by temperature, SACP flow levels and venous congestion. In clinical practice, the regional differences in perfusion during SACP may be of pathogenic importance in focal cerebral ischaemia. Furthermore, the reduced superior vena cava cannula flow may pass undetected during bicaval cardiopulmonary bypass if the superior vena cava flow is not specifically monitored.

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Bikhchandani, Jai. "Extracorporeal liver perfusion as liver support device : a pilot study." Thesis, University of Leicester, 2012. http://hdl.handle.net/2381/11038.

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Introduction: A liver support device can bridge a patient in acute liver failure safely to transplant. An extracorporeal perfused porcine liver (ECLP) circumvents the limitations of hepatocyte based bioartificial liver, but its clinical application has been limited so far due to the potential risk of transmission of porcine endogenous retroviruses. Aim of this study was to develop an ECLP model that can provide artificial hepatic support across a semi-permeable membrane which should block porcine viruses due to its pore size. Methods: 50-60 Kg white landrace pigs treated with standard abattoir animal procedures were used as donors. The liver was perfused with normothermic autologous oxygenated blood using Medtronic BioMedicus BP560 driven centrifugal pump for 6 hours. This ECLP system was used to support a surrogate patient circulation across the filter Evaclio EC4A. Substances like galactose, ammonia, midazolam and para-aminobenzoic acid, were infused into the surrogate patient and their clearance was calculated. The study was designed as test (n=15) vs. control (n=5); with control experiments having no liver in the circuit. Results: After the optimization phase (n=23), we successfully perfused 15 porcine livers with the mean hepatic artery pressure of 87 mm Hg and flows of 1.2 L /min. Retention of Indocyanine green at 15 minutes was 11% in test and 96% in controls. Mean ammonia clearance of 945 mg/min/kg, galactose Vmax of 111.7 mg/min/Kg, hippurate ratio of 91% and a variable midazolam clearance was seen in the test experiments. Conclusion: The study was successful in proving the feasibility of an ECLP model based on abattoir animals that can be utilised for future research work. This model was able to provide adequate support to the surrogate patient across a hollow filter. Further work is needed to show that an ECLP system can be used in an anhepatic animal prior to application in human trials.

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Nishitai, Ryuta. "Influence of Extracorporeal Porcine Liver Perfusion on Non-Human Primates : Minimizing Hemolysis Improves Subsequent Survival." Kyoto University, 2001. http://hdl.handle.net/2433/150173.

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Chinchilla-Mendez, Joshua A. "A Computational Fluid Dynamics study of scaffolds under perfusion flow." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/231384/1/Joshua_Chinchilla-Mendez_Thesis.pdf.

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This thesis explored the potential of utilising Computational Fluid Dynamics simulations to design and improve a perfusion bioreactor for practical mesenchymal stromal cell experimentation. This method of simulations allowed for an in-depth analysis of the microfluidic nature within the custom-designed parallel plate flow chamber, creating the conditions the 3D PCL Scaffold carrying these cells would undergo. The focus on the simulated velocities and resulting shear stresses upon the scaffold surfaces (cells attachment site) ensures the cells survive. Further investigation was taken to improve cell retention on the PCL scaffold through plasma treating technique prior to seeding which was successful.

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Schön, Michael R. "Transplantation von Lebern nicht-herzschlagender Spender im Schweineleber-Transplantationsmodell." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/13727.

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Es wurde untersucht ob die normotherme extrakorporale Leberperfusion (NELP) als Methode geeignet ist, Lebern vor Transplantation zu konservieren, und ob sie warm ischämische Zellschäden beheben kann. Zum ersten Mal konnte experimentell gezeigt werden, daß eine erfolgreiche Transplantation nach 4 Stunden mit NELP möglich ist und sogar so zuverlässig, wie die Kaltkonservierung in der University of Wisconsin Lösung. Die NELP erhält die Leberfunktion und ermöglicht eine Regeneration warm ischämischer Schäden in Nicht-herzschlagenden Spendern. 36 Schweine der Deutschen Landrasse wurden in sechs Gruppen transplantiert. In der Gruppe 1 wurde direkt nach Organentnahme transplantiert, in Gruppe 2 nach 4 Stun-den Kaltkonservierung in der University of Wisconsin Lösung und in Gruppe 3 nach 4 Stunden NELP. In Gruppe 4 wurden die Lebern nach 60 Minuten warmer Ischämie direkt transplantiert, in Gruppe 5 nach 60 Minuten warmer Ischämie und 4 Stunden Kaltkonservierung und in Gruppe 6 nach 60 Minuten warmer Ischämie und 4 Stunden NELP. Alle Tiere deren Lebern vor Transplantation normotherm extrakorporal perfun-diert wurden (Gruppen 3 und 6) überlebten mit guter Organfunktion. Im Unterschied hierzu führte die Abfolge von 60 Minuten warmer Ischämie und 4 Stunden Kaltkonser-vierung unweigerlich zur primären Organ-Nichtfunktion innerhalb der ersten 24 Stun-den nach Lebertransplantation. Die Methode der NELP bietet die Chance eine Leber außerhalb des Körpers für Zeiträume von möglicherweise länger als 4 Stunden völlig funktionsfähig zu halten. Die NELP kann zur Organkonservierung vor Transplantation eingesetzt werden, aber auch dazu, Lebern von Nicht-Herzschlagenden Spendern zu nutzen.
Normothermic extracorporeal liver perfusion (NELP) was studied as a means to pre-serve livers for transplantation and to reverse warm ischemic injury. For the first time we provide experimental evidence that successful transplantation after 4h of normo-thermic extracorporeal liver perfusion is possible and as reliable as 4h of cold preser-vation in University of Wisconsin solution. NELP preserves liver function completely and is capable of reversing 60 min of warm ischemic injury in non heart beating do-nors. 36 German Landrace pigs were transplanted in six groups. Group 1 animals were transplanted directly, group 2 animals after 4h of cold preservation with University of Wisconsin solution and group 3 animals following 4h of normothermic extracorporeal liver perfusion. Group 4 animals sustained 1h of warm ischemia before transplantation of the liver. In group 5 animals were transplanted following 1h of warm ischemia and 4h of cold preservation, and in group 6 after 1h of warm ischemia and 4h of normo-thermic extracorporeal liver perfusion. All animals receiving livers treated by normo-thermic extracorporeal liver perfusion survived without liver failure (group 3 and 6). In contrast, all animals in group 5 developed primary graft non-function within 24 h after transplantation. The technique of NELP holds the potential to keep a mammalian liver outside the body completely functional, possibly for longer than 4h. NELP can be used for liver preservation prior to transplantation or to utilise organs from non-heart-beating donors.

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Adham, Mustapha. "Assistance hépatique par xénoperfusion extracorporelle de foie de porc : modèles d'études expérimentales et pré-cliniques." Lyon 1, 2000. http://www.theses.fr/2000LYO1T034.

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Quentin, Pierre. "Etude de l'effet d'une perfusion de glucose insuline potassium administree avant la circulatione xtra corporelle en chirurgie cardiaque." Lyon 1, 1988. http://www.theses.fr/1988LYO1M294.

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Viguier, Catherine. "Libération de médiateurs d'origine endothéliale au cours d'une CEC foetale à débit pulsé : études expérimentales et implications cliniques." Lyon 1, 2000. http://www.theses.fr/2000LYO1T149.

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AOUIFI, ABDELLAH. "Effets de deux regimes de perfusion differents sur la glycemie et l'insulinemie au cours d'une cure de cardiopathie congenitale sous circulation extracorporelle chez l'enfant : a propos de 40 observations." Lyon 1, 1994. http://www.theses.fr/1994LYO1M300.

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Kwasnicka, Karina Lacava. "Procedimentos básicos padronizados aplicados nos períodos pré, trans e pós-circulação extracorpórea em cães." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-31052004-145959/.

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O objetivo desta dissertação foi descrever em veterinária seqüência padrão de procedimentos que devem ser realizados nos períodos pré, trans e pós-circulação extracorpórea (CEC) para sua aplicação em cão, com base na literatura existente, e em observações levadas a efeito no Laboratório de Cirurgia Cardiotorácica, do Departamento de Cirurgia da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo. O referido trabalho concerne sobre a escolha do material, montagem e preparo da máquina ECOBEC ? Braile Biomédica - para circulação extracorpórea em cães, e descreve procedimentos básicos para entrada, condução, monitorização e saída de CEC, a fim de obter-se resultado técnico exeqüível no procedimento. Diante do exposto na literatura compulsada, baseado na metodologia e material proposto e com observações pessoais, é licito afirmar que esta é factível, desde que obedecidos os preceitos enumerados e descritos no presente trabalho para os períodos pré, trans e pós-circulação extracorpórea.
The purpose of this assay was to describe the standard basic procedures that should be followed before, during, and after cardiopulmonary bypass (CPB) in dogs, based on the existing literature and personal observations that took place in the Laboratory of Cardiothoracic Surgery, of the Surgical Department of the Faculdade de Medicina Veterinária e Zootecnia of the University of São Paulo. This assay reports how to choose the material, to prepare and to assemble the ECOBEC machine ? Braile Biomédica ? for cardiopulmonary bypass in dogs, and describes the basic procedures to start, conduct, follow up and finish it, in order to obtain a feasible technical results. Based on the literature, based on the methodology and material proposed and personal observations, it is reliable to state that this procedure can be accomplished since all paths described are followed before, during and after cardiopulmonary bypass.

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Книги з теми "Extracorporeal perfusion"

Taggart, David, and Yasir Abu-Omar. Heart surgery. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0098.

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Cardiac surgery is still a relatively young specialty, having been developed only in the latter half of the twentieth century with the introduction of extracorporeal circulation or ‘cardiopulmonary bypass’ (CPB). This initiated the era of open heart surgery, initially allowing the repair of congenital heart defects, then valve replacements, coronary artery bypass grafting (CABG), and, finally, heart transplantation. Over the last two decades, improvements in medical, anaesthetic, and surgical management of patients, allied to refinements in extracorporeal perfusion technology, have resulted in a decreasing mortality and morbidity from heart surgery despite the advanced age and significant comorbidity of many patients. Today, heart surgery continues to improve the prognosis and quality of lives of patients around the world. Surgical techniques and technologies continue to evolve and recent years have witnessed the emergence of, amongst others, the use of long-lasting conduits for CABG procedures, beating-heart (‘off-pump’) surgery, the use of minimally invasive and robotic techniques, and long-term mechanical circulatory support.

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Navaratnam, M., and C. Ramamoorthy. Hypoplastic Left Heart Syndrome. Edited by Kirk Lalwani, Ira Todd Cohen, Ellen Y. Choi, and Vidya T. Raman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190685157.003.0009.

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Approximately 960 babies are born per year in the United States with hypoplastic left heart syndrome. Over the last 20 years, advances in surgical techniques, perioperative care, cardiopulmonary bypass, and intensive care unit management have converted this previously fatal condition to one with a neonatal survival rate of 90% to 92% for standard risk patients. Understanding the factors affecting the balance of pulmonary blood flow and systemic blood flow and ensuring adequate cardiac output and end-organ perfusion is critical to successful outcomes. Extracorporeal membrane oxygenation remains an important support modality following stage I palliation. This chapter discusses this syndrome and describes treatment options.

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Blaikley, John, and Andrew J. Fisher. Lung transplantation. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198702948.003.0011.

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This chapter describes common issues along the transplantation journey from assessment to common conditions that are diagnosed post transplantation. Assessment for transplant suitability against several objective criteria is covered as well as the importance of optimizing techniques prior to this. Recent advances mean that some patients can now be bridged to transplant using extracorporeal membrane oxygenation (ECMO) when previously they would have been removed from the transplant list. Drawbacks to ECMO are discussed. Ex-vivo lung perfusion (EVLP) of a donor organ is covered. Follow-up is considered, especially in the early phase whilst being stabilized on their new medications as well as monitoring for the development of lung rejection (acute and chronic). These conditions often present when patients are being seen away from the transplant centre. CF patients have the best outcomes of the groups after lung transplantation, emphasising that lung transplantation should be considered in this specific group of patients.

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Garner, Justin, and David Treacher. Intensive care unit and ventilation. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199657742.003.0009.

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Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by rapidly developing hypoxaemic respiratory failure and bilateral pulmonary infiltrates on chest X-ray. ALI/ARDS are a relatively frequent diagnosis in protracted-stay patients in the intensive care unit. The pathology is a non-specific response to a wide variety of insults. Impaired gas exchange, ventilation-perfusion mismatch, and reduced compliance ensue. Mechanical ventilation is the mainstay of management, along with treatment of the underlying cause. Mortality remains very high at around 40%. The condition is challenging to treat. Injury to the lungs, indistinguishable from that of ARDS, has been attributed to the use of excessive tidal volumes, pressures, and repeated opening and collapsing of alveoli. Lung-protective strategies aim to minimize the effects of ventilator-induced lung injury. Use of low tidal volume ventilation has been shown to improve mortality. Emerging ventilatory therapies include high-frequency oscillatory ventilation and extracorporeal membrane oxygenation.

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Rady, Mohamed Y., and Ari R. Joffe. Non-heart-beating organ donation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0390.

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The transplantation community endorses controlled and uncontrolled non-heart-beating organ donation (NHBD) to increase the supply of transplantable organs at end of life. Cardiac arrest must occur within 1–2 hours after the withdrawal of life-support in controlled NHBD. Uncontrolled NHBD is performed after failed cardiopulmonary resuscitation in an unexpected witnessed cardiac arrest. Donor management aims to protect transplantable organs against warm ischaemic injury through the optimization of haemodynamics and mechanical ventilation. This also requires antemortem instrumentation and systemic anticoagulation for organ perseveration in controlled NHBD. Interval support with extracorporeal membrane oxygenation or cardiopulmonary bypass is generally required for optimal organ perfusion and oxygenation in uncontrolled NHBD, which remains a controversial medical practice. There are several unresolved ethical challenges. The circulatory criterion of 2–10 minutes of absent arterial pulse does not comply with the uniform determination of death criterion of the irreversible cessation of functions of the cardiovascular or central nervous systems. There are no robust safeguards in clinical practice that can prevent faulty prognostication, and premature withdrawal of treatment or termination of cardiopulmonary resuscitation. Unmanaged conflicting interests of increasing the supply of transplantable organs can have serious consequences on the medical care of potentially salvageable patients. Perimortem interventions can interfere with the delivery of an optimal quality of end-of-life care. The lack of disclosure of these NHBD ethical controversies does not uphold the moral obligation for an informed consent.

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Частини книг з теми "Extracorporeal perfusion"

Anastasiadis, Kyriakos, Polychronis Antonitsis, and Helena Argiriadou. "Perfusion Principles." In Principles of Miniaturized ExtraCorporeal Circulation, 43–50. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-32756-8_4.

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Ebert, Paul. "Extracorporeal Perfusion in Infants." In International Practice in Cardiothoracic Surgery, 641–44. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4259-2_52.

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Cortes-Cerisuelo, Miriam. "Liver Preservation with Extracorporeal Perfusion." In Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation, 275–88. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51331-3_16.

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Gabriel, Edmo Atique, and Tomas Salerno. "Extracorporeal Circuit Pathways for Lung Perfusion." In Principles of Pulmonary Protection in Heart Surgery, 279–85. London: Springer London, 2010. http://dx.doi.org/10.1007/978-1-84996-308-4_30.

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Hafström, L., and P. Naredi. "Isolated Hepatic Perfusion with Extracorporeal Oxygenation Using Hyperthermia TNFα and Melphalan: Swedish Experience." In Isolated Liver Perfusion for Hepatic Tumors, 120–26. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-80460-1_12.

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Walter, C., R. Häring, J. Jakschik, U. Kania, E. Renk, L. C. Tung, D. Weber, and A. Wondzinski. "Extracorporeal Perfusion with Baboon Liver in Acute Hepatic Failure." In Experimental and Clinical Hepatology, 260–67. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4151-9_37.

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Babin-Ebell, Jörg, M. Misoph, and O. Elert. "Cytokine release regarding different perfusion systems and its effect on S100B protein levels." In Current Perspectives of the Extracorporeal Circulation, 67–75. Heidelberg: Steinkopff, 2000. http://dx.doi.org/10.1007/978-3-642-57721-5_7.

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Terajima, H., Y. Shirakata, T. Yagi, S. Mashima, H. Shinohara, S. Satoh, Y. Arima, et al. "Long-duration xenogeneic extracorporeal pig liver perfusion with human blood." In Transplant International, 388–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-662-00818-8_94.

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Abouna, G. M. "Extracorporeal Xenogeneic Liver Perfusion for the Treatment of Hepatic Failure." In Xenotransplantation, 785–92. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60572-7_57.

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Walther, H., H. Müller, and K. R. Aigner. "Inhibition of Proteases During Extracorporeal Extremity Perfusion Experimental and Clinical Results." In Advances in Experimental Medicine and Biology, 565–67. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1057-0_73.

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Тези доповідей конференцій з теми "Extracorporeal perfusion"

Fujii, Yutaka, Mikiyasu Shirai, Shuji Inamori, Yoshiaki Takewa, and Eisuke Tatsumi. "Investigation of the biological effects of artificial perfusion using rat extracorporeal circulation model." In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2014. http://dx.doi.org/10.1109/embc.2014.6944619.

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Ivanov, Borislav, and Jordan Kralev. "Re-structuring, Quality Assessment and Telemedicine Integration of an Extracorporeal Perfusion Apparatus Controller." In 2019 8th Mediterranean Conference on Embedded Computing (MECO). IEEE, 2019. http://dx.doi.org/10.1109/meco.2019.8760011.

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Ivanov, Ivan Evg, Vesselin Gueorguiev, and Desislava Georgieva. "Software Structure, Program Generation and Schedulability Analysis of Extracorporeal Perfusion Pump Embedded Controller." In 2019 8th Mediterranean Conference on Embedded Computing (MECO). IEEE, 2019. http://dx.doi.org/10.1109/meco.2019.8760025.

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Ivanov, Borislav. "A model of extracorporeal perfusion pump: Left heart camera operation modeling and simulation." In 2018 7th Mediterranean Conference on Embedded Computing (MECO). IEEE, 2018. http://dx.doi.org/10.1109/meco.2018.8405983.

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Badimon, L., J. J. Badimon, V. Turitto, and V. Fuster. "PLATELET INTERACTION WITH ARTIFICIAL SURFACES UNDER DEFINED FLOW CONDITIONS: ROLE OF VON WILLEBRAND FACTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642916.

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Анотація:

Platelets deposit onto artificial surfaces to form mono or multilayers which under certain conditions lead to gross thrombus formation and eventual failure of graft material. Both hemodynamic and blood related factors determine the interaction of blood cells with prosthetic inplants. The objective of this study has been to ascertain the extent to which vWF plays a role in platelet deposition onto artificial surfaces over a range of shear conditions. Polytetrafluoroethylene (PTFE) vascular graft segments were exposed to blood flow in a tubular perfusion chamber with well characterized rheological conditions. The perfusion chamber with test material was placed within an extracorporeal circuit (carotid artery-jugular vein) in normal swine and swine with inherited homozygous vWD. Platelet deposition was measured by labelling autologous platelets with 111Indium and also by optical morphometry of epoxy embedded specimens. Electron microscopy was performed in selected samples. Studies were performed with heparinized blood (300u/Kg iv) for perfusion times of 1 to 10 minutes. Platelet deposition increased with wall shear rate and with exposure time in the presence of vWF (vWF: 89 ± 11%) but in its absence (vWF: < 3%) platelet deposition was significantly(*) inhibited at high (1690s 1, shown below) but not at low (212s x) shear rate. Results are Platelets x 106 /cm2±lSE.Plasma and platelet vWF play an important role in platelet-deposition and stabilization of thrombus growth on a synthetic biomaterial as we have previously observed on vascular surfaces

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Badimon, L., J. J. Badimon, and V. Fuster. "ACUTE THROMBOSIS IN STENOTIC AREAS: IMPORTANCE OF THE VASCULAR MATRIX EXPOSED TO BLOOD." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642842.

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The platelet response to angioplasty or spontaneous plaque rupture leads to acute thrombotic occlusion under certain conditions. We analyzed the role of local shear rate (flow and vessel cross-section related), the nature of the exposed matrix and the effect of thrombin inhibition in platelet acute response to injury. Collagen type I (exposed in plaque rupture) and de-endothelialized pig aorta (mild injury) were exposed to pig blood in a tubular perfusion chamber with well characterized flow conditions, placed within an extracorporeal circuit in swine (N=20). Platelet deposition was measured by labeling autologous platelets with Indium and optical morphometry of epoxy embedded specimens. Selected specimens were analyzed by electron microscopy. Unanticoagulated blood and blood from animals treated with 300u/Kg of heparin were perfused over the substrate for 3 and 10 min at local shear rates typical of unobstructed arteries (212s™1 - 424s™1) and of stenotic vessel (824s™1 - 1690s™1). Platelet deposition (Platelets × 106/cm2 ± SE) for 3 min perfusions were:Platelet deposition is dependent on the reactivity of the vascular matrix exposed to blood and on the local shear rate. The greatest rate of thrombus growth is observed with collagen and high shear rate conditions which may precipitate acute thrombotic occlusion in stenotic regions, mainly when the coagulation pathway is not inhibited (255×l06 platelets/ cm2 in 3 minutes. The relative contribution of rheology and the isolated components of the atherosclerotic plaque matrix exposed to blood in the onset of acute coronary syndromes will be differentiated with this experimental model.

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