Добірка наукової літератури з теми "Extracellular matrix fragments"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Extracellular matrix fragments".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "Extracellular matrix fragments"
McKeown-Longo, P. J., and D. F. Mosher. "Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts." Journal of Cell Biology 100, no. 2 (February 1, 1985): 364–74. http://dx.doi.org/10.1083/jcb.100.2.364.
Повний текст джерелаUnsold, C., M. Hyytiainen, L. Bruckner-Tuderman, and J. Keski-Oja. "Latent TGF-beta binding protein LTBP-1 contains three potential extracellular matrix interacting domains." Journal of Cell Science 114, no. 1 (January 1, 2001): 187–97. http://dx.doi.org/10.1242/jcs.114.1.187.
Повний текст джерелаSchedin, P., R. Strange, T. Mitrenga, P. Wolfe, and M. Kaeck. "Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling." Journal of Cell Science 113, no. 5 (March 1, 2000): 795–806. http://dx.doi.org/10.1242/jcs.113.5.795.
Повний текст джерелаOlmo, N., J. Turnay, G. Risse, R. Deutzmann, K. von der Mark, and M. A. Lizarbe. "Modulation of 5′-nucleotidase activity in plasma membranes and intact cells by the extracellular matrix proteins laminin and fibronectin." Biochemical Journal 282, no. 1 (February 15, 1992): 181–88. http://dx.doi.org/10.1042/bj2820181.
Повний текст джерелаBekaert, Sandrine, Marianne Fillet, Benoit Detry, Muriel Pichavant, Raphael Marée, Agnes Noel, Natacha Rocks, and Didier Cataldo. "Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis." Cancer Growth and Metastasis 10 (January 1, 2017): 117906441774553. http://dx.doi.org/10.1177/1179064417745539.
Повний текст джерелаADAIRKIRK, T., and R. SENIOR. "Fragments of extracellular matrix as mediators of inflammation." International Journal of Biochemistry & Cell Biology 40, no. 6-7 (June 2008): 1101–10. http://dx.doi.org/10.1016/j.biocel.2007.12.005.
Повний текст джерелаWAGA, SHINOBU, KAZUHIKO SUGIMOTO, HIROSHI TANAKA, TATSUO ITO, TOHRU NAKAHATA, TAKASHI TATEYAMA, YOSHIKI KAKIZAKI, and MASARU YOKOYAMA. "IgA Interaction with Carboxy-Terminal 43-kD Fragment of Fibronectin in IgA Nephropathy." Journal of the American Society of Nephrology 10, no. 2 (February 1999): 256–63. http://dx.doi.org/10.1681/asn.v102256.
Повний текст джерелаChristopher, R. A., S. R. Judge, P. A. Vincent, P. J. Higgins, and P. J. McKeown-Longo. "The amino-terminal matrix assembly domain of fibronectin stabilizes cell shape and prevents cell cycle progression." Journal of Cell Science 112, no. 19 (October 1, 1999): 3225–35. http://dx.doi.org/10.1242/jcs.112.19.3225.
Повний текст джерелаChakraborty, Abir, Natasha Marie-Eraine Boel, and Adrienne Lesley Edkins. "HSP90 Interacts with the Fibronectin N-terminal Domains and Increases Matrix Formation." Cells 9, no. 2 (January 22, 2020): 272. http://dx.doi.org/10.3390/cells9020272.
Повний текст джерелаGaggar, Amit, and Nathaniel Weathington. "Bioactive extracellular matrix fragments in lung health and disease." Journal of Clinical Investigation 126, no. 9 (September 1, 2016): 3176–84. http://dx.doi.org/10.1172/jci83147.
Повний текст джерелаДисертації з теми "Extracellular matrix fragments"
Muir, Paula Louise. "Age-related changes and the effect of fibronectin fragments on the composition of the extracellular matrix of the meniscus." Thesis, Royal Veterinary College (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406036.
Повний текст джерелаVallet, Sylvain D. "Structure et interactions de la lysyl oxydase et de fragments de la matrice extracellulaire." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1296.
Повний текст джерелаThe extracellular matrix is an intricate tridimensional network supporting cells and a bioactive molecule reservoir involved in the regulation of cell behavior. It is composed of 1027 proteins in humans (Naba et al., Matrix Biol. 2016), including 274 of the core matrisome and 753 associated proteins (growth factors and extracellular matrix regulators) and 6 glycosaminoglycans including 5 sulfated. The extracellular matrix is altered in numerous pathologies (Bonnans et al., Nat. Rev. Mol. Cell Biol. 2014). The lysyl oxidase is responsible for the cross-linking of collagens and elastin and is involved in many cancers. The extracellular matrix is a reservoir of bioactive fragments named matricryptins which are released by proteolysis of extracellular matrix proteins and regulate numerous biological processes like angiogenesis and adipogenesis (Ricard-Blum et Vallet, Matrix Biol. 2017). We have expressed under a recombinant form in human cells some matricryptins including the ectodomains of the membrane collagens XIII, XVII, XXIII and XXV and have identified their extracellular partners. We have characterized the propeptide of lysyl oxidase by SEC-MALS, dynamic light scattering, and SAXS and have built a coarse-grained 3D model by SAXS-derived constraints. We have identified 17 new partners of this fragment and analyzed the mutant Arg158Gln which has no biological activity. This mutation has been identified in humans and inhibits the propeptide anti-proliferative properties. It is associated to an increased risk of breast cancer (Min et al., Cancer Res. 2009). We have expressed the mature lysyl oxidase and modelled its tridimensional structure using available data. All the interactions identified in this study were associated to manually curated interactions described in the literature to build the first version of the human extracellular interactions network
Lai, Andrew. "Towards the development of novel bispecific antibodies to inhibit key cell surface receptors integral for the growth and migration of tumour cells." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/101339/1/Andrew_Lai_Thesis.pdf.
Повний текст джерелаManuel, Rachel. "Propriétés anti-angiogéniques d'un fragment dérivé du collagène V : mécanismes moléculaires et perspectives thérapeutiques." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10001.
Повний текст джерелаThe basement membrane plays an important role in angiogenesis by providing support necessary for blood vessel formation and supplying endogenous pro- and anti-angiogenic factors that condition the endothelial cells behavior. CoLV is present at the vicinity of endothelial cell basement membrane? We previously showed that a fragment derived from COLV a1, named HEPV, contains a functional heparin binding site, inhibits specifically endothelial cell proliferation and migration and disrupts endothelial tube formation. Prolonged treatment with HEPV results in the activation of collagen IV a1 and collagene XVIII a1 expression, the parental molecules of the anti-angiogenic fragments arresten and endostatin respectively. Heparin binding sites have been involved in the regulation of FGF2-induced angiogenesis. Soluble HEPV significantly inhibits phosphorylation of ERK1/2 and AKT in FGF2-stimuled endothelial cells. Moreover, in vivo experimentation using the mouse angiogenesis subcutaneous sponge assay shows that HEPV accumulates at angiogenic sites and inhibits FGF-2-induced angiogenesis. HEPV also significantly lowers intra-tumoral angiogenesis and tumor xenograft growth in nude mice. We also showed that hypoxia, the major angiogenesis-inducing factor, induces Collagen V production by endothelial cells and the release of a fragment encompassing HEPV into the culture medium. Finally, the released of HEPV-containing fragments in vivo was attested by the immunodetection of the fragment with specific antibodies in human breast cancer in which collagen V is overexpressed. Collectively, our results qualify HEPV as a new endogenous regulator angiogenesis with possible application in cancer therapy
Carvalho, Eduardo George Baptista de. "Integração de fragmento de fascia lata enxertado na lamina propria de prega vocal de cães : estudo histologico." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313720.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-06T13:38:08Z (GMT). No. of bitstreams: 1 Carvalho_EduardoGeorgeBaptistade_M.pdf: 6583260 bytes, checksum: c2467f978ca8069f79000308c237d538 (MD5) Previous issue date: 2006
Resumo: A correção de alterações da lâmina própria nas pregas vocais, como sulcos, cicatrizes e degenerações senis, ainda é um desafio à fonocirurgia. Materiais implantáveis e métodos de implantação são continuamente investigados. Este trabalho avaliou a utilização de enxerto de fragmento da faseia lata na lâmina própria da prega vocal de cães, estudando as alterações histológicas conseqüentes, quanto à reação inflamatória aguda e crônica, à fibrose e ã neovascularização. Doze cães adultos foram submetidos à enxertia de um fragmento de 0,3 X 0,3 cm da faseia lata na lâmina própria da prega vocal direita. Na prega vocal esquerda, o mesmo acesso cirúrgico foi reproduzido, sem colocação do enxerto. Após dois e seis meses, os animais foram sacrificados e suas pregas vocais estudadas histologicamente. A faseia não induziu resposta inflamatória, aguda ou crônica, em qualquer animal, nem desencadeou fibrose além da conseqüente ao procedimento cirúrgico, como observado no lado controle. Em todos os casos, identificou-se o tecido enxertado sem evidências de reabsorção e com aumento da neovascularização, demontrando que a faseia lata apresenta integração tecidual boa na camada superficial da lâmina própria de prega vocal de cão
Abstract: Satisfactory corrective treatment for sulcus, scar and senile alterations in the lamina propria of vocal folds is still under development. This study assessed the utilization of a fascia lata graft in the vocal fold lamina propria of dogs by analyzing the histological alterations induced by acute and chronic inflammatory reactions as well as the fibrosis triggered by graft procedure and persistence. A fragment measuring 0.3 X 0.3 cm of the fascia lata was grafted in the right vocal old lamina propria of 12 adult dogs. Identical surgical access in the left vocal fold was reproduced without introducing the graft. After periods of two and six months, the animals were sacrificed and a histological study of their vocal cords was performed. Besides the reactions resulting from the surgical procedure in the control side, the fascia did not induce an acute or chronic inflammatory reaction or trigger fibrosis in any of the animals. In all the cases, the grafted tissue did not show evidence of resorption, demonstrating that the superficial layer of the lamina propria in dogs presents good tolerance to fascia lata grafting
Mestrado
Otorrinolaringologia
Mestre em Ciências Médicas
Asselot-Chapel, Catherine. "Biosynthèse des macromolécules de la matrice extracellulaire par les cellules mésenchymateuses : régulation transcriptionnelle, modifications dans le diabète et modulation pharmacologique par des fragments d'héparine." Paris 12, 1991. http://www.theses.fr/1991PA120030.
Повний текст джерелаSoulez, Mathilde. "Le fragment LG3 du perlécan : un nouveau régulateur de remodelage vasculaire en transplantation." Thèse, 2012. http://hdl.handle.net/1866/9130.
Повний текст джерелаIn allogeneic transplanted organs, endothelial apoptosis is associated with vascular remodeling and neointima formation which in turn leads to allograft vasculopathy, a maladaptive form of vascular repair. In allograft vasculopathy, neointima results from the accumulation of leukocytes, extracellular matrix and alpha-smooth muscle actin positive (αSMA+) cells in the intima of allogeneic arteries, arterioles and capillaries. Neointimal αSMA+ cells comprise vascular smooth muscle cells (VSMC) derived from the donor and stem cells derived from the recipient, including mesenchymal stem cells (MSC). Acquisition of an anti-apoptotic phenotype of neointimal cells is central to the development of vascular obliterative changes. Dr Hébert’s team demonstrated that apoptotic endothelial cells release mediators which in turn induce a state of resistance to apoptosis of VMSC and fibroblasts. Apoptotic endothelial cells release cathepsin-L which cleaves perlecan therefore releasing a C-terminal fragment harbouring a laminin G motif and referred to as LG3. LG3 is anti-apoptotic for fibroblasts. We hypothesized that LG3 is a key mediator produced by endothelial apoptosis of importance in favoring neointima formation via the induction of an anti-apoptotic phenotype in αSMA+ neointimal cells We demonstrated that mediators released by endothelial apoptosis induce an ERK1/2-dependent anti-apoptotic phenotype in MSC. We identified LG3 as one of the mediators implicated in the induction of this anti-apoptotic response. Interactions between LG3 and beta 1 integrins expressed on MSC trigger ERK1/2 activation albeit to a lesser degree than medium conditioned by apoptotic endothelial cells. We showed that apoptotic endothelial cells also release EGF which cooperates with LG3 to induce an anti-apoptotic phenotype on MSC through cross-talk between EGF receptor and integrin-dependent pathways. Next, we characterized the impact of LG3 on allogeneic vascular remodeling in vivo. We developed a murine model of vascular rejection based on orthotopic transplantation of an aortic segment between two fully MHC-incompatible mice in absence of immunosuppression. Recombinant LG3 was injected intravenously post-transplantation in recipients resulting in higher circulating levels of LG3. In LG3-injected mice, accumulation of αSMA+ neointimal cells was enhanced resulting in significantly increased intima/media ratios in the allogeneic aortic graft. Aortic grafts of LG3-injected allografts also showed decreased CD31+ cells. We also demonstrated, using cell-based approaches, that LG3 exerts a pro-migratory activity on VSMC through beta 1-integrin and ERK1/2 -dependent pathways. In line with these observations we also reported augmented serum LG3 in human renal transplant patients in association with acute vascular rejection episodes. Collectively these results suggest that the pro-migratory, pro-survival and angiostatic activities of LG3 contribute to neointima formation. Our results suggest that LG3 is a novel mediator of importance in the development of obliterative vascular remodeling associated with rejection of allogeneic organs.
Labelle, Andrée. "Clonage du domaine V du perlécan et étude de son activité biologique." Thèse, 2005. http://hdl.handle.net/1866/15586.
Повний текст джерелаЧастини книг з теми "Extracellular matrix fragments"
Chalikias, Georgios K., and Dimitrios N. Tziakas. "Biomarkers of the Extracellular Matrix and of Collagen Fragments." In Biomarkers in Cardiovascular Disease, 87–124. Dordrecht: Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-007-7678-4_5.
Повний текст джерелаChalikias, Georgios K., and Dimitrios N. Tziakas. "Biomarkers of the Extracellular Matrix and of Collagen Fragments." In Biomarkers in Cardiovascular Disease, 1–38. Dordrecht: Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-007-7741-5_5-1.
Повний текст джерелаEvans, John Spencer, and Sunney I. Chan. "The N-terminal fragment of bovine phosphophoryn, an extracellular mineral matrix protein, shares sequence homology with viral, bacterial and eukaryotic transcriptional and post-translational regulatory proteins." In Proteins, 251–59. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-010-9063-6_35.
Повний текст джерелаТези доповідей конференцій з теми "Extracellular matrix fragments"
Edgar, Lowell T., Steve A. Maas, James E. Guilkey, and Jeffrey A. Weiss. "A Continuous-Discrete Finite Element Model of Angiogenesis That Couples Vessel Growth With Matrix Deformation." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14327.
Повний текст джерелаde Groot, Philip G., Jan A. van Mourik, and Jan J. Sixma. "PRIMARY BINDING SITE OF VON WILLEBRAND FACTOR IN THE SUBENDOTHELIUM WHICH MEDIATES PLATELET ADHESION IS NOT COLLAGEN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643587.
Повний текст джерелаWasi, S., S. Juodvalkis, P. Alles, and J. E. Aubin. "STUDIES ON THE DIRECT PROTEOLYTIC ACTION OF HUMAN TISSUE PLASMINOGEN ACTIVATOR ON HUMAN FIBRONECTIN AND VITRONECTIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644376.
Повний текст джерелаBeneckv, M. J., C. G. Kolvenbach, D. L. Amrani, and M. W. Mosesson. "EVIDENCE THAT THE C-TERMINAL HEPARIN BINDING DOMAIN ("HEP II") DOMINATES HEPARIN-FIBRONECTIN INTERACTIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643631.
Повний текст джерелаEldor, A., M. Bar-Ner, L. Wasserman, Y. matzner, Z. Fuks, and I. Viodavsky. "HEPARIN AND NON-ANTICOAGULANT HEPARINS INHIBIT HEPARANASE ACTIVITY IN NORMAL AND MALIGNANT CELLS:POSSIBLE THERAPEUTIC USE IN PREVENTION OF EXTRAVASATION AND DISSEMINATION OF BLOOD BORNE CELLS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643664.
Повний текст джерелаSchleuning, W. D. "THE BIOCHEMISTRY AND CELL BIOLOGY OF SINGLE CHAIN UROKINASE TYPE PLASMINOGEN ACTIVATOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642956.
Повний текст джерелаKruithof, E. KO, W. D. Schleuning, and F. Bachman. "PLASMINOGEN ACTIVATOR INHIBITOR BIOCHEMICAL AND CLINICAL ASPECTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644764.
Повний текст джерелаЗвіти організацій з теми "Extracellular matrix fragments"
Pines, Mark, Arieh Bar, David A. Carrino, Arnold I. Caplan, and James A. Dennis. Extracellular Matrix Molecules of the Eggshell as Related to Eggshell Quality. United States Department of Agriculture, 1997. http://dx.doi.org/10.32747/1997.7575270.bard.
Повний текст джерела