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Добірка наукової літератури з теми "Extended half-life"

Автор: Grafiati

Опубліковано: 12 квітня 2025

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Статті в журналах з теми "Extended half-life"

Kontermann, Roland E. "Half-life extended biotherapeutics." Expert Opinion on Biological Therapy 16, no. 7 (April 18, 2016): 903–15. http://dx.doi.org/10.1517/14712598.2016.1165661.

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FUJII, Teruhisa. "Extended half life coagulation products for hemophilia." Japanese Journal of Thrombosis and Hemostasis 28, no. 4 (2017): 472–79. http://dx.doi.org/10.2491/jjsth.28.472.

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Padhi, Desmond, Liyun Ni, Blaire Cooke, Rafael Marino, and Graham Jang. "An Extended Terminal Half-Life for Darbepoetin Alfa." Clinical Pharmacokinetics 45, no. 5 (2006): 503–10. http://dx.doi.org/10.2165/00003088-200645050-00005.

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Morfini, Massimo. "A new, promising, extended half-life rFIX concentrate." Lancet Haematology 4, no. 2 (February 2017): e59-e60. http://dx.doi.org/10.1016/s2352-3026(17)30003-0.

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Nesspor, Thomas C., and Bernard Scallon. "Chimeric antibodies with extended half‐life in ferrets." Influenza and Other Respiratory Viruses 8, no. 5 (July 30, 2014): 596–604. http://dx.doi.org/10.1111/irv.12273.

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Croteau, S. E., and E. J. Neufeld. "Transition considerations for extended half-life factor products." Haemophilia 21, no. 3 (April 9, 2015): 285–88. http://dx.doi.org/10.1111/hae.12683.

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Graf, Lukas. "Extended Half-Life Factor VIII and Factor IX Preparations." Transfusion Medicine and Hemotherapy 45, no. 2 (2018): 86–91. http://dx.doi.org/10.1159/000488060.

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Kontermann, Roland E. "Strategies for extended serum half-life of protein therapeutics." Current Opinion in Biotechnology 22, no. 6 (December 2011): 868–76. http://dx.doi.org/10.1016/j.copbio.2011.06.012.

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Tortella, Bartholomew J., José Alvir, Margaret McDonald, Dean Spurden, Patrick F. Fogarty, Amit Chhabra, and Andreas M. Pleil. "Real-World Analysis of Dispensed IUs of Coagulation Factor IX and Resultant Expenditures in Hemophilia B Patients Receiving Standard Half-Life Versus Extended Half-Life Products and Those Switching from Standard Half-Life to Extended Half-Life Products." Journal of Managed Care & Specialty Pharmacy 24, no. 7 (July 2018): 643–53. http://dx.doi.org/10.18553/jmcp.2018.17212.

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GEHRING, R., R. E. BAYNES, A. L. CRAIGMILL, and J. E. RIVIERE. "Feasibility of Using Half-Life Multipliers To Estimate Extended Withdrawal Intervals following the Extralabel Use of Drugs in Food-Producing Animals." Journal of Food Protection 67, no. 3 (March 1, 2004): 555–60. http://dx.doi.org/10.4315/0362-028x-67.3.555.

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Under the Animal Medicinal Drug Use Clarification Act of 1994, veterinarians are legally allowed to use drugs in food-producing animals in an extralabel manner. This could potentially lead to violative residues in food of animal origin. It is therefore essential that an appropriately extended withdrawal interval be established. Ideally, these extended withdrawal intervals should be calculated on the basis of the tissue half-life of the drug in the target animal. However, these data are not readily available for all drugs of extralabel use in food-producing animals. For this reason, the use of a half-life multiplier has been proposed as a simple alternative method to estimate the effective tissue half-life of a drug. Extended withdrawal intervals, estimated using various half-life multipliers, were compared with the withdrawal intervals calculated using actual tissue half-lives. For the group of drugs investigated, a half-life multiplier of 5 resulted in estimates of extended withdrawal intervals that were potentially inadequate to prevent violative tissue residues for drugs that had relatively long tissue half-lives, high tolerances, or both. This is possibly because fewer half-lives are required for these drugs to reach the target tissue concentrations following administration at label doses. Use of a smaller half-life multiplier (in this case 3) is therefore suggested to ensure that extended withdrawal intervals are adequate to prevent violative tissue residues.

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Більше джерел

Дисертації з теми "Extended half-life"

Zhu, Eric F. (Eric Franklin). "Synergistic anti-tumor immune response to combination immunotherapy consisting of anti-tumor antibodies, extended half-life Interleukin-2, and other immunomodulatory agents." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/107872.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2016.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 109-123).
Cancer immunotherapies under development have generally focused on either stimulating T-cell immunity or driving antibody-directed effector functions of the innate immune system such as antibody-dependent cell-mediated cytotoxicity (ADCC). However, as our understanding of antitumor immune responses grows, it has become increasingly apparent that single agent therapies may be insufficient to effectively stimulate all aspects of a complex robust anti-tumor response in a large proportion of patients. Thus, rational combination of single agent immunotherapies has become an area of increasing interest. In this work, we find that a combination of an anti-tumor antigen antibody and an untargeted IL-2 fusion protein with delayed systemic clearance induces significant tumor control in aggressive isogenic tumor models via a concerted innate and adaptive response. We find that this therapy induces the infiltration of various immune effectors such as neutrophils, eosinophils NK cells, and CD8+ T-cells that appear to direct cytolytic activity against tumor cells. This combination therapy also induces an intratumoral "cytokine storm," potentially re-polarizing the tumor microenvironment into one that is immunologically anti-tumor. We also identify cross-talk between NK cells and macrophages to induce intratumoral recruitment of neutrophils but with the requisite presence of anti-tumor antibodies and IL-2 simultaneously. We further enhanced the efficacy of this two-component therapy with the addition of a potent amphiphile-based anti-tumor peptide vaccine in combination with checkpoint blockade of anti-PD-I and anti-CTLA-4. This multi-component therapy was tested in a setting of a low-mutational burden GEM lung cancer model with a single known and targetable antigen: human carcinoembryonic antigen (CEA). We find that in the subcutaneous setting and autochthonous setting, both components of checkpoint blockade are necessary for full efficacy. While a 5- component therapy is admittedly unwieldy for clinical translation, understanding the complementary yet non-overlapping contributions of each agent may inform improved development of additional immunotherapy agents and their combinations in the clinic.
by Eric F. Zhu.
Ph. D.

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Desage, Stéphanie. "Facteurs VIII et IX humains recombinants à demi-vie prolongée pour le traitement de l’hémophilie A et B." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10305.

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L’hémophilie est une pathologie hémorragique rare, due à un déficit en facteur VIII (FVIII) pour l’hémophilie A et en facteur IX (FIX) pour l’hémophilie B. La sévérité de la maladie est corrélée à l’activité plasmatique du FVIII ou du FIX. Ainsi, les hémophiles sévères ont une activité du FVIII ou FIX inférieure à 1 IU/dL et présentent des accidents hémorragiques spontanés nécessitant l’introduction d’une prophylaxie intraveineuse. Depuis les années 2010, des thérapeutiques à demi-vie prolongée ont été développées, afin de réduire la fréquence des injections intraveineuses et d’améliorer la qualité de vie des patients. La 1ère partie de ce travail consistait à caractériser les mécanismes d’allongement de la demi-vie d’un FIX humain recombinant (rhFIX) fusionné à la sous-unité B du facteur XIII (FXIIIB), développé par notre équipe. Le rôle des interactions avec l’albumine et le fibrinogène a été démontré pour l’allongement de la demi-vie. Dans un second temps, nous avons essayé de développer un rhFVIII à demi-vie prolongée par fusion au FXIIIB, selon les mêmes modalités que pour le FIX. Malheureusement, compte-tenu de la taille importante de la construction, aucun FVIII fonctionnel n’a pu être produit. Enfin, le 3ème axe de ce travail correspondait à de la recherche clinique avec l’évaluation de l’apport de la technique chromogénique du dosage du FVIII en cas de traitement avec l’efmoroctocog alfa en contexte chirurgical. Nous avons pu montrer que le dosage chromogénique du FVIII permettait des adaptations thérapeutique d’efmoroctocog alfa de façon efficace, sûre, et bien tolérée en contexte chirurgical
Haemophilia is a rare inherited bleeding disorder caused by a deficiency in clotting factors: factor VIII (FVIII) in haemophilia A and factor IX (FIX) in haemophilia B. The severity of the condition is determined by the plasma activity levels of FVIII or FIX. Patients with severe haemophilia typically have FVIII or FIX levels below 1 IU/dL, leading to spontaneous bleeding episodes that require prophylactic treatment. Since the 2010s, extended half-life coagulation factors have been developed to reduce the frequency of intravenous infusions and enhance patients' quality of life. In the first phase of our study, we explored the mechanisms responsible for the extended half-life of a FIX fused to the Factor XIII B subunit (FXIIIB). Our findings demonstrated that the extended half-life of this molecule is attributed to its ability to bind to fibrinogen and albumin. In the second phase of our study, we attempted to develop an extended half-life FVIII by fusing it with FXIIIB. However, due to the large size of the construct, no functional FVIII could be successfully produced. The third part of our research focused on the clinical use of efmoroctocog alfa, as more real-world data is needed on its application. Our results show that the use of a chromogenic FVIII assay to assess plasma FVIII activity during surgery provides more accurate results that correlate with clinical outcomes, we also confirmed in real life conditions that the use of efmoroctocog alfa is effective, safe and well tolerated

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Книги з теми "Extended half-life"

Silveira, Maria J., and Phillip Rodgers. Advance directives and advance care planning. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198802136.003.0020.

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This chapter discusses the history of advance directives (ADs) and Advance Care Planning (ACP) in the United States of America, the evidence base regarding the application of ADs and ACP in American healthcare, and the use of technology to facilitate ACP and AD in the US. Improvements in public health and biomedical technology during the latter half of the twentieth century substantially extended life expectancy in the US from 47 in 1900 to 79 by 2014. This accomplishment paired with the aging of America’s largest generation (know fondly as the ‘baby boomers’), is largely responsible for an exponential increase in expenditures related to healthcare over the last 20 years.

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Rowe, Anne. Iris Murdoch. Liverpool University Press, 2019. http://dx.doi.org/10.3828/liverpool/9780746312162.001.0001.

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This volume takes into account the variety of talents that inform not only Iris Murdoch’s twenty-six best-selling novels, but also her philosophical, theological and critical writing, which together express stringent views on art, politics and morality. It identifies Murdoch as a proudly Anglo-Irish writer whose work straddles the boundary between popular and intellectually serious novels which spanned the entire latter half of the twentieth century. This thematically based study outlines the overarching themes and issues that characterise her fiction decade by decade; explores her unique role as a British philosopher-novelist; explains the paradoxical nature of her outspoken atheism and highlights the neglected aesthetic aspect of her fiction, which innovatively extended the boundaries of realist fiction by borrowing from the visual arts, drama, poetics and music. The importance of the settings of her homeland of Ireland and her beloved London concludes the study, and while Iris Murdoch is acknowledged throughout as a writer who vividly evokes the zeitgeist of the late twentieth century she is also presented as one whose unconventional life and complex presentation of gender and psychology speaks perhaps more urgently to twenty-first century readers than they did to those of the century in which she wrote.

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Mitchell, Lee Clark. More Time. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198839224.001.0001.

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More Time is an extended essay on the contemporary short story focused on four recent collections: Alice Munro’s Dear Life (2012); Andre Dubus’s Dancing After Hours (1996); Joy Williams’s The Visiting Privilege (2015); and Lydia Davis’s Can’t and Won’t (2014). Each publication has appeared near the conclusion of a career devoted all but exclusively to short stories, with each defining a “late style” honed over a lifetime. As well, each diverges from others in ways that have profoundly shaped our generic conceptions, and collectively they represent the four most innovative practitioners of the past half-century (with the arguable exception of Raymond Carver). Yet in an era when writing programs, The New Yorker, and distinguished journals all promulgate the short story, it remains relatively under-examined as a major literary form. We continue to argue about what a story inherently is, ignoring how differences among practitioners enliven the field. Dubus, Munro, Williams, and Davis each defy critical efforts to identify the story form’s presumed constitution, marked by a supposedly special shape or requisite length or distinct narrative trajectory. And the very contrast among their efforts reveals the expansiveness of the genre, though few have taken such a cross-glancing interpretive approach. My effort is to open up discussion, shifting from close analysis into larger speculation about possibilities established by the most innovative writers in their later work.

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Grass, Tim. Restorationists and New Movements. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199683710.003.0007.

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Presbyterians and Congregationalists arrived in colonial America as Dissenters; however, they soon exercised a religious and cultural dominance that extended well into the first half of the nineteenth century. The multi-faceted Second Great Awakening led within the Reformed camp by the Presbyterian James McGready in Kentucky, a host of New Divinity ministers in New England, and Congregationalist Charles Finney in New York energized Christians to improve society (Congregational and Presbyterian women were crucial to the three most important reform movements of the nineteenth century—antislavery, temperance, and missions) and extend the evangelical message around the world. Although outnumbered by other Protestant denominations by mid-century, Presbyterians and Congregationalists nevertheless expanded geographically, increased in absolute numbers, spread the Gospel at home and abroad, created enduring institutions, and continued to dominate formal religious thought. The overall trajectory of nineteenth-century Presbyterianism and Congregationalism in the United States is one that tracks from convergence to divergence, from cooperative endeavours and mutual interests in the first half the nineteenth century to an increasingly self-conscious denominational awareness that became firmly established in both denominations by the 1850s. With regional distribution of Congregationalists in the North and Presbyterians in the mid-Atlantic region and South, the Civil War intensified their differences (and also divided Presbyterians into antislavery northern and pro-slavery southern parties). By the post-Civil War period these denominations had for the most part gone their separate ways. However, apart from the southern Presbyterians, who remained consciously committed to conservatism, they faced a similar host of social and intellectual challenges, including higher criticism of the Bible and Darwinian evolutionary theory, to which they responded in varying ways. In general, Presbyterians maintained a conservative theological posture whereas Congregationalists accommodated to the challenges of modernity. At the turn of the century Congregationalists and Presbyterians continued to influence sectors of American life but their days of cultural hegemony were long past. In contrast to the nineteenth-century history of Presbyterian and Congregational churches in the United States, the Canadian story witnessed divergence evolving towards convergence and self-conscious denominationalism to ecclesiastical cooperation. During the very years when American Presbyterians were fragmenting over first theology, then slavery, and finally sectional conflict, political leaders in all regions of Canada entered negotiations aimed at establishing the Dominion of Canada, which were finalized in 1867. The new Dominion enjoyed the strong support of leading Canadian Presbyterians who saw in political confederation a model for uniting the many Presbyterian churches that Scotland’s fractious history had bequeathed to British North America. In 1875, the four largest Presbyterian denominations joined together as the Presbyterian Church in Canada. The unifying and mediating instincts of nineteenth-century Canadian Presbyterianism contributed to forces that in 1925 led two-thirds of Canadian Presbyterians (and almost 90 per cent of their ministers) into the United Church, Canada’s grand experiment in institutional ecumenism. By the end of the nineteenth century, Congregationalism had only a slight presence, whereas Presbyterians, by contrast, became increasingly more important until they stood at the centre of Canada’s Protestant history.

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Частини книг з теми "Extended half-life"

Abraham, Sunil, and Elizabeth M. Duncan. "A Review of Factor VIII and Factor IX Assay Methods for Monitoring Extended Half-Life Products in Hemophilia A and B." In Methods in Molecular Biology, 569–88. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3175-1_37.

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Güngör, Bengü. "Circular Economy Business Model Framework Considering Product Sustainability." In Creating a Roadmap Towards Circularity in the Built Environment, 305–15. Cham: Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-45980-1_25.

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AbstractWith the development of technology and industry, which started in the latter half of the twentieth century, environmental degradation intensified because of the depletion of natural resources, global warming, the disintegration of the ozone layer, acid rain, droughts, and other issues. The Sustainable Development Goals (SDGs) have inspired the creation of a brand-new business, economic, environmental, and social structure model called the Circular Economy (CE) concept, which is an alternative to the current linear economy and contends that all things in nature are in constant transformation with one another. At this point, it is now important to extend the product's useable and functional lifespans as well as the point at which it stops working. This study primarily seeks to give a foundation for developing a circular economy business model considering the product life cycle before outlining how it is integrated. The relationship between sustainability and the circular economy is first and foremost. After that, the circular economy and extended lifespan of product strategies are defined using literature research. All defined actions and decision points are used to design the phases of a model framework. In conclusion, it thinks the suggested framework will help the decision-makers who want to include circular economy principles into their business procedures, especially based on the manufacturing process. No matter how the business model relates to a specific industry, the framework's general behavior will surely help managers decide on the application stages.

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Reimers, Fernando M., and Francisco Marmolejo. "Leading Learning During a Time of Crisis. Higher Education Responses to the Global Pandemic of 2020." In Knowledge Studies in Higher Education, 1–41. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-82159-3_1.

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AbstractThe rapid disruptions caused by the Covid-19 pandemic in multiple sectors and areas of daily life provide a unique opportunity to study the university’s capacity to respond to changes in the external environment, to be a learning organization, in service of addressing significant social challenges. In this book we study universities’ responses to one such challenge: the disruption to educational opportunities caused by the interruption of schooling brought about by the pandemic.In response to the Covid-19 pandemic, universities innovated on several fronts. Unsurprisingly, some of those innovations focused on internal actions implemented to mitigate the impact of the pandemic by transitioning to online teaching delivery or extension of semester break, etc. (Crawford J et al. J Appl Learning Teaching 3.1:1–20, 2020; Leon-Garcia F, Cherbowski-Lask A, Leadership responses to COVID 19: a global survey of college and university leadership. International Association of Universities – Santander Universities. IAUP. https://www.iaup.org/wp-content/uploads/2020/11/IAUP-Santander_Survey_to_COVID-19_Report2020.pdf, 2020). Beyond the solutions to mitigate the pandemic’s impact on their communities of students, faculty, or staff, universities also innovated to mitigate such impact on the larger community. While the contributions of universities to alleviate the pandemic’s impact have been most visible in public health (Daniels, R. J. 2020. Universities’ Vital Role in the Pandemic Response. Hopkins Bloomberg Public Health Magazine. https://magazine.jhsph.edu/2020/universities-vital-role-pandemic-response), they have extended to other areas of relief and support as well. Almost half of universities participating in a global survey conducted by the International Association of Universities indicated that due to the pandemic, their community engagement had increased (Marinoni G et al. The impact of Covid-19 on higher education around the world. IAU global survey report. International Association of Universities, Paris. https://www.iau-aiu.net/IMG/pdf/iau_covid19_and_he_survey_report_final_may_2020.pdf, 2020).This book is a study of one such response of universities to the pandemic which has not yet received sufficient attention: their support of schools at the pre-collegiate level through a variety of innovative approaches to mitigate the impact of the pandemic on opportunity to learn.In this chapter, we argue that studying such innovations provides insight into the responsiveness of universities to complex societal needs and into their capacity to operate as learning organizations open to their external environment. We introduce the study, explain its value in understanding the role and nature of higher education’s outreach, social impact, and capacity to deal with complex challenges, and summarize the chapters of the book and the results of a survey which was administered to over one-hundred universities to study the nature of their collaborations with schools during the first 9 months of the pandemic, between March and December of 2020.

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Ingram, David. "9. Creating and Sustaining the Care Information Utility." In Health Care in the Information Society, 395–526. Cambridge, UK: Open Book Publishers, 2023. http://dx.doi.org/10.11647/obp.0384.05.

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We come now to the most challenging questions concerning the care information utility: how, where and by whom will it be created and sustained, and under what governance arrangements? This chapter looks to the wider and future scene, to consider how the work described in Chapters Eight and Eight and a Half can be extended and sustained, in the context of greater opportunity and need for individual self-management of care and supportive services that move from a fragmenting culture of ‘What is the matter with you?’ to an integrative culture of ‘What matters to you?’ We must embrace an iterative and incremental approach here, where we learn by doing. The chapter is thus not prescriptive; it rather reflects on the nature of the challenges faced and what we should have in mind in framing our policy and practice in tackling them. Central to this will be the approach and method adopted for implementation of a coherent and trusted information utility that every citizen can feel part of and contribute to, which helps and supports them along the way as they seek health and wellbeing in their own lives, and the lives of those they care for. The chapter highlights the importance of the Creative Commons and public domain governance that bridges with and preserves the non-exclusive relationship with private enterprise. The story of common land and its appropriation to private interests through the eighteenth-century Enclosure Acts in the UK, is visited as a parable of common ground in the Information Age. It discusses the harm that restriction of intellectual property does in blocking innovation that tackles intractable ‘wicked problems’, which require connection and collaboration on common ground, within diversely connected communities of practice. The chapter then focuses on the work of implementing and sustaining the care information utility and the environments, teams and communities whereby it is enabled and supported. It looks at the different qualities of leadership that such pioneering endeavours require and exemplify, and playfully compares them with the principles outlined in The Art of War, the classic text of Sun Tzu, which is much used in elite management courses on leadership. With its focus on people and environments, this part of the chapter draws a great deal on people I have known and worked with, and environments we worked in and created together, and is thus especially personal and autobiographical. Trust in and recognition of individual and communal roles and responsibilities must unite citizens with the multiple professions and communities of health care practice, around shared goals for the care information utility. Governance arrangements will thus constitute a third major component of implementation of a utility that is coherent, effective, efficient, equitable, stable and life-enhancing, in support of health care services for the Information Society of tomorrow. These threefold challenges of implementation will require strong alliances—the theme I reflect on, in parenthesis, at the end of the chapter.

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Snyder, Sherri. "One." In Barbara La Marr. University Press of Kentucky, 2017. http://dx.doi.org/10.5810/kentucky/9780813174259.003.0002.

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This chapter details the ancestry of Reatha Watson (a.k.a. Barbara La Marr), born July 28, 1896, in Yakima, Washington, to William Watson and Rose (Contner) Watson. Her father and mother’s life histories, as well as her father’s noteworthy career as a newspaperman, are presented, and her brother and half-siblings, paternal and maternal grandparents, and various extended family members are discussed. The stage for Reatha’s nomadic childhood, prompted by her father’s career and inborn restlessness, is set. Factors that will give rise to and condition certain of Reatha’s predominant personality traits are established. The chapter concludes with Reatha’s birth.

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Dowling, Álvaro, and Kai-Uwe Lewandrowski. "The Implications of Low Back Pain on Prolonged Lifespan and Future Targeted Care Models to Support the Pursuit of Healthy Longevity." In Regenerative Medicine & Peripheral Nerve Endoscopy, 1–15. BENTHAM SCIENCE PUBLISHERS, 2024. http://dx.doi.org/10.2174/9789815274462124010003.

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The human desire for everlasting youth and well-being has persisted throughout history. In the modern era, advancements in medicine and the emerging field of longevity have brought this age-old aspiration closer to realization. The remarkable increase in global life expectancy from a mere 30 years in 1870 to an impressive 71 years today, is a monumental healthcare achievement over the past century and a half. This achievement carries profound implications for the economy, necessitating a deeper understanding of the aging process and its influence on economic decision-making. Furthermore, it raises concerns regarding the adjustments required in behavior and lifestyle to adapt to extended lifespans while maintaining a high quality of life. The rise in life expectancy has substantial implications for managing chronic health conditions. Low back pain is nearly ubiquitous, and its global disease burden, particularly in high-socioeconomic standard countries, is high. The youth and longevity business has carved out a niche from the traditional healthcare industry solely concerned with maintaining a high quality of life while managing the aging process. In this chapter, the authors deliver their perspective on the economic decision-making patterns of an aging population, the demographic changes associated with extended lifespans, and the adaptations in retirement planning and utilization of healthcare systems and social welfare programs. Further, the authors reflect on how aging spine patients adjust their behaviors and lifestyles to align with the demands of prolonged lifespans, prompting considerations of the economic consequences of these adjustments. The pursuit of healthy longevity raises questions about productivity, workforce participation, and the financial implications of supporting extended retire ment periods. Healthy longevity refers to empowering individuals to lead longer lives while maintaining optimal physical, mental, and emotional well-being. Achieving healthy longevity entails making choices that significantly impact long-term health outcomes. The authors describe how the otherwise healthy low back pain patient over 50 should adopt a healthy lifestyle, including regular exercise, balanced nutrition, and stress management, to promote healthy aging while enhancing the quality of life during extended lifespans.

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Junior, Nyasha, and Jeremy Schipper. "Samson and the Making of American Martyrs." In Black Samson, 35–48. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190689780.003.0004.

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By the 1850s, some abolitionists had begun to use the term “Samson” to refer to those involved in insurrections by enslaved persons. By the dawn of the Civil War, they extended that term to describe real-life persons who fought to end slavery. In the last half of the nineteenth century, poets, clergy, scholars, and other intellectuals began to identify biblical Samson with historical individuals who challenged racial oppression in America. The biblical hero had already become a potent symbol of African Americans’ collective strength in the fight against slavery and other barriers to social advancement. Eventually, he became associated with those who took up this struggle through passionate rhetoric, violence, and, at times, political compromise. In the process, persons like John Brown, Fredrick Douglass, Gabriel Prosser, Nat Turner, and Booker T. Washington became memorialized as larger-than-life Samson figures.

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Fennell, Jack. "The Undead Generations." In Rough Beasts, 158–85. Liverpool University Press, 2020. http://dx.doi.org/10.3828/liverpool/9781789620344.003.0007.

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The first half of this chapter establishes the historical context for depictions of the corporeal undead (i.e. reanimated corpses in various forms, such as zombies, vampires and other revenants, as opposed to ghosts, spirits and less-substantial beings). This context incorporates not just the concept of abjection – which describes the actions by which the ‘unclean’ is removed from the space of everyday life – but also looks at Ireland’s haphazard history when it comes to the management of death, from the dilapidation of graveyards to grave-robbing to lackadaisical death registration. All of these factors combined the make burial spots ‘porous’ rather than hermetically sealed, so that death leaked into the space of the living. A number of texts are considered against this backdrop to suggest a general sense of what it means to be undead in Ireland. The second half of the chapter is given over to vampires, and the ways in which the dominant trends in analyses of vampire stories (allegorical reading and humanisation) fail to do justice to the vampire’s unique nature. This extended argument looks at two classic Irish vampire tales, Carmilla and Dracula.

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Joseph, Jipson, and Ananya Pandey. "Right-Based Approach to Reproductive Autonomy." In Advances in Public Policy and Administration, 185–208. IGI Global, 2024. http://dx.doi.org/10.4018/979-8-3693-7837-3.ch007.

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Discussion on reproductive health became prominent in the second half of the 20th century. The Declaration of the universality of human rights energized a right-based approach to reproductive health. Many women realized that without reproductive rights the questions on their dignity, equality, liberty, and life would become meaningless. This right-based approach got momentum in USA and extended to other countries, including India. But both these countries did not consider right to abortion as an absolute right. In India, the enactment of Medical Termination of Pregnancy Act, 1971 considered it as a limited right. The US judiciary in its Roe judgment in 1973 considered it under right to privacy in the ambit of right to liberty but only as a limited right. However, this judgment was overruled by the Dobbs judgment in 2022. In this context, this chapter attempts to compare the perspectives of both USA and India on reproductive health.

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Ehrenreich, Andreas. "Horváth, Ödön von (Edmund Josef von Horváth) (1901–1938)." In Routledge Encyclopedia of Modernism. London: Routledge, 2024. http://dx.doi.org/10.4324/9780415249126-rem2151-1.

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Born in Fiume to an aristocratic family, Horváth went to school in Budapest and Vienna and studied German literature and theatre in Munich. He left university, without graduating, to pursue the career of a writer. After an intense period of literary production in the second half of the 1920s, he received the prestigious Kleist Prize in 1931. His socio-critical plays became exceptionally popular as their author proved to be a keen observer of the economic crisis that tragically altered the life of the middle and working classes. Although his work displayed leftist tendencies, Horváth had an ambivalent attitude towards National Socialism. While his books were officially banned, he took advantage of his Hungarian nationality to work in the Fascist film industry. An extended series of ill success drove the playwright to emigration. He was not able to realize this plan as he died in a tragic accident at the Champs Elysées in Paris.

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Тези доповідей конференцій з теми "Extended half-life"

Li, Xiaofan, Cristina Abrahams, Amandeep Gakhal, Junhao Yang, Kevin Brar, Daniel Calarese, Robert Henningsen, et al. "1359 Half-life extended engineered IL18 variants that escape the negative regulation of IL18BP." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1359.

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Basran, Amrik, Emma Jenkins, Estelle Adam, Floriane Laurent, Michele Writer, Assa Oumie, Jyrki Sivula, et al. "Abstract 4108: Preclinical evaluation of half-life extended Affimer® biotherapeutics targeting the PD-L1 pathway." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4108.

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Yam, Alice, Kshama Doshi, Krishna Bajjuri, Millicent Embry, Frank Xiao, Grace Lee, Stephanie Armstrong, et al. "1103 Half-life extended, conditionally active IFNa prodrug induces tumor-selective activation and potent antitumor response." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1103.

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Yu, chunxiao, Kurt Shanebeck, Shiwen Zhang, Jeanine Ruiz, Ray Chuang, Yuanxia Yuan, Yong Wen, et al. "Abstract 1742: Activatable Fc-IL-15 and anti-PD1 -IL-15 fusion molecules with extended half-life." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1742.

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Digiandomenico, A., A. Dippel, R. Varkey, A. Lidwell, L. Zhuang, V. Godfrey, Z. Bhuiyan, et al. "Identification of a New IgG mAb Format with Enhanced Complement Mediated Effector Function and Extended Half Life." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4648.

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Kristensen, Jens Bjelke, Lisbeth Elster, Morten Lundh, Borja Ballarín-González, Flora Alexopoulou, Martin Kræmer, Ditte Marie Jensen, et al. "Pipeline for development of acylated peptide-based CGRP receptor antagonist with extended half-life for migraine treatment." In 37th European Peptide Symposium, 2200. The European Peptide Society, 2024. http://dx.doi.org/10.17952/37eps.2024.p2200.

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Arvedson, Tara L., Mercedesz Balazs, Pamela Bogner, Kurt Black, Kevin Graham, Anja Henn, Matthias Friedrich, et al. "Abstract 55: Generation of half-life extended anti-CD33 BiTE® antibody constructs compatible with once-weekly dosing." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-55.

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Lemon, Bryan, Wade Aaron, Richard Austin, Patrick Baeuerle, Manasi Barath, Adrie Jones, Susan D. Jones, et al. "Abstract 1773: HPN424, a half-life extended, PSMA/CD3-specific TriTAC for the treatment of metastatic prostate cancer." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1773.

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Miebach, G., S. Juranek, V. Lieftüchter, C. Bidlingmaier, and M. Olivieri. "Switching to extended half-life rFVIIIfc: transition of therapy and pharmacokinetics in pediatric patients with severe hemophilia A." In GTH Congress 2023 – 67th Annual Meeting of the Society of Thrombosis and Haemostasis Research – The patient as a benchmark. Georg Thieme Verlag, 2023. http://dx.doi.org/10.1055/s-0042-1760547.

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Звіти організацій з теми "Extended half-life"

De Paiva Abreu, Marcelo. The Political Economy of High Protection in Brazil before 1987. Inter-American Development Bank, April 2004. http://dx.doi.org/10.18235/0011099.

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The paper is concerned with the high protection cum high growth experience in Brazil until the second half of the 1980s and its crisis. The paper is structured in four sections. The first section is a summary of the arguments presented in the following three sections of the paper. Section II considers the level of protection in Brazil compared with those of other Latin American economies and examines the reasons why it was so high while its economic growth performance was outstanding. The following section analyses the golden age of autarky until the early 1960s, including the role of foreign direct investment (FDI). The last section centers on the combination of export incentives with closed domestic markets that extended the life of import substitution industrialization (ISI) as a decreasingly effective economic strategy.

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