Дисертації з теми "Exploration noise"
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Lloyd-Jones, Rebecca Louise. "Amid the Noise: A Percussionist's Exploration of Creative Practice." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/370333.
Повний текст джерелаThesis (Masters)
Master of Music Research (MMusRes)
Queensland Conservatorium
Arts, Education and Law
Full Text
Parsons, Adrian. "Seismic exploration techniques applied to ultrasonic imaging within concrete." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368818.
Повний текст джерелаLevine, Matthew Jason. "A framework for technology exploration of aviation environmental mitigation strategies." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54437.
Повний текст джерелаMiller, Nolan W. "Athenian Acoustics: A Sonic Exploration." Ohio University Honors Tutorial College / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556289254557967.
Повний текст джерелаSyversætre, Johannessen Vega. "White Noise : An exploration of tufted surfacesin relation to sound, physicalcontact and tactility." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-615.
Повний текст джерелаRajendran, Aravind. "Noise Margin, Critical Charge and Power-Delay Tradeoffs for SRAM Design Space Exploration." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1307667225.
Повний текст джерелаSetiawan, Panji. "Exploration and optimization of noise reduction algorithms for speech recognition in embedded devices /." Aachen : Shaker, 2009. http://d-nb.info/99453583X/04.
Повний текст джерелаLautakoski, Johan. "Procedurell generering av terräng Perlin noise eller Diamond-Square : med fokus på exekveringstid och framkomlighet." Thesis, Högskolan i Skövde, Institutionen för informationsteknologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-12940.
Повний текст джерелаSetiawan, Panji [Verfasser]. "Exploration and Optimization of Noise Reduction Algorithms for Speech Recognition in Embedded Devices / Panji Setiawan." Aachen : Shaker, 2009. http://d-nb.info/1156517788/34.
Повний текст джерелаWhite, Robert J. "Exploration of a Strategy for Reducing Gear Noise in Planetary Transmissions and Evaluation of Laser Vibrometry as a Means for Measuring Transmission Error." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1129928063.
Повний текст джерелаKitchen, Robert Raymond. "Exploration, quantification, and mitigation of systematic error in high-throughput approaches to gene-expression profiling : implications for data reproducibility." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5691.
Повний текст джерелаArs, Jean-Michel. "Inversion conjointe géophysique appliquée à l'exploration en géothermie profonde dans le Massif Central." Thesis, Brest, 2018. http://www.theses.fr/2018BRES0025.
Повний текст джерелаThe development of geothermal energy has led to the exploitation of resources established in varied geological and geodynamic contexts. Geophysical exploration of these complex reservoirs requires the use of several complementary imaging methods. This PhD thesis focuses on the exploration of a geothermal resource located within the fractured basement in the French Massif Central using magnetotelluric, ambient noise tomography and gravimetry. Magnetotelluric is a 3D imaging method with a good resolution power that is sensitive to the presence of water and hydrothermal weathering clays but is limited by its spatial coverage. Seismic noise tomography has a good vertical resolution but does not resolve well horizontal velocity variations. This method is sensitive to variations of the mechanical properties of rocks and thus to fractured media. Finally gravimetry brings constraint on the lithological variations and has a good lateral resolution but lacks vertical resolution.We present a method of joint inversion of seismic and gravimetric data under the constraint of a resistivity model obtained by independent magnetotelluric inversion. Joint inversion requires defining model couplings. By lack of prior knowledge of petrophysical relationships, we have coupled the density, resistivity and velocity models with a law that constraints the parameters to be correlated on average.This strategy aims to bring out the characteristic relationships of the geological objects of the geothermal resource. This joint inversion methodology has been tested on synthetic models. The application to the real data acquired in the Massif Central has made it possible to define a deep zone of high correlation interpreted as the fragile ductile transition. The intermediate part of the models, more homogeneous, allows to distinguish different geological units separated by a fault zone. Finally the superficial part is distinguished by strong heterogeneity of the parameters resulting probably from surface alteration process
Ventura, Raphaël. "Estimation de la pollution sonore en milieu urbain par assimilation d'observations mobiles." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS387.
Повний текст джерелаNoise pollution is a major environmental health problems, and the determination of populations exposure is needed. This can be done through noise mapping. Usually, maps are simulation-based, and subject to high uncertainties. Observational data is distributed in space and time and hence conveys information that is complementary to simulation data. In this thesis, we propose data assimilation methods that allow one to merge prior noise maps issued by numerical simulation with phone-acquired (via the Ambiciti app) noise observations. We run a performance analysis that addresses the range, accuracy, precision and reproducibility of measurements. Conclusions of this evaluation lead us to the proposition of a calibration strategy that has been embedded in Ambiciti. The result of the prior map and observations merging is called an analysis, and is designed to have minimum error variance, based on the respective uncertainties of both data sources that we evaluated: spatial correlations for the prior error; measurement errors, time and location representativeness for the observations. We address the estimation problem on two different scales. The first method relies on the so-called ``best linear unbiased estimator''. It produces hourly noise maps, based on temporally averaged simulation maps and mobile phone audio data recorded at the neighborhood scale. The second method leverages the crowd-sensed Ambiciti user data available throughout the covered city. The observations set must be filtered and pre-processed, in order to only select the ones that were generated in adequate conditions. The prior simulation map is then corrected in a global fashion
Setiawan, Panji [Verfasser], Harald [Akademischer Betreuer] Höge, Harald [Gutachter] Höge, and Tim [Gutachter] Fingscheidt. "Exploration and Optimization of Noise Reduction Algorithms for Speech Recognition in Embedded Devices / Panji Setiawan ; Gutachter: Harald Höge, Tim Fingscheidt ; Akademischer Betreuer: Harald Höge ; Universität der Bundeswehr München, Fakultät für Elektrotechnik und Informationstechnik." Neubiberg : Universitätsbibliothek der Universität der Bundeswehr München, 2009. http://d-nb.info/1191856364/34.
Повний текст джерелаSetiawan, Panji [Verfasser], Harald [Akademischer Betreuer] Höge, Harald Gutachter] Höge, and Tim [Gutachter] [Fingscheidt. "Exploration and Optimization of Noise Reduction Algorithms for Speech Recognition in Embedded Devices / Panji Setiawan ; Gutachter: Harald Höge, Tim Fingscheidt ; Akademischer Betreuer: Harald Höge ; Universität der Bundeswehr München, Fakultät für Elektrotechnik und Informationstechnik." Neubiberg : Universitätsbibliothek der Universität der Bundeswehr München, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:706-6109.
Повний текст джерелаSetiawan, Panji Verfasser], Harald [Akademischer Betreuer] [Höge, Harald [Gutachter] Höge, and Tim [Gutachter] Fingscheidt. "Exploration and Optimization of Noise Reduction Algorithms for Speech Recognition in Embedded Devices / Panji Setiawan ; Gutachter: Harald Höge, Tim Fingscheidt ; Akademischer Betreuer: Harald Höge ; Universität der Bundeswehr München, Fakultät für Elektrotechnik und Informationstechnik." Neubiberg : Universitätsbibliothek der Universität der Bundeswehr München, 2009. http://d-nb.info/1191856364/34.
Повний текст джерелаWee, Bee Leng. "Death rattle : an exploration." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289908.
Повний текст джерелаCerf, Loïc. "Constraint-based mining of closed patterns in noisy n-ary relations." Lyon, INSA, 2010. http://theses.insa-lyon.fr/publication/2010ISAL0050/these.pdf.
Повний текст джерелаLes processus de découverte de connaissances nouvelles peuvent être fondés sur des motifs locaux extraits de grands jeux de données. Concevoir des algorithmes de fouille de données efficaces pour calculer des collections de motifs pertinents est un domaine actif de recherche. Beaucoup de jeux de données enregistrent si des objets présentent ou non certaines propriétés; par exemple si un produit est acheté par un client ou si un gène est sur exprimé dans un échantillon biologique. Ces jeux de données sont des relations binaires et peuvent être représentés par des matrices 0/1. Dans de telles matrices, un ensemble fermé est un rectangle maximal de '1's modulo des permutations arbitraires des lignes (objets) et des colonnes (propriétés). Ainsi, chaque ensemble fermé sous tend la découverte d'un sous ensemble maximal d'objets partageant le même sous ensemble maximal de propriétés. L'extraction efficace de tous les ensembles fermés, satisfaisant des contraintes de pertinences définies par l'utilisateur, a été étudiée en profondeur. Malgré son succès dans de nombreux domaines applicatifs, ce cadre de travail se révèle souvent trop étroit. Tout d'abord, beaucoup de jeux de données sont des relations n-aires, c'est à dire des tenseurs 0/1. Réduire leur analyse à deux dimensions revient à ignorer des dimensions additionnelles potentiellement intéressantes; par exemple où un client achète un produit (analyse spatiale) ou quand l'expression d'un gène est mesurée (analyse cinétique). La présence de bruit dans la plupart des jeux de données réelles est un second problème qui conduit à la fragmentation des motifs à découvrir. On généralise facilement la définition d'un ensemble fermé pour la rendre applicable à des relations de plus grande arité et tolérante au bruit (hyper rectangle maximal avec une borne supérieure de '0's tolérés par hyperplan). Au contraire, généraliser leur extraction est très difficile. En effet, les algorithmes classiques exploitent une propriété mathématique (la connexion de Galois) des ensembles fermés qu'aucune des deux généralisations ne préserve. C'est pourquoi notre extracteur parcourt l'espace des motifs candidats d'une façon originale qui ne favorise aucune dimension. Cette recherche peut être guidée par une très grande classe de contraintes de pertinence que les motifs doivent satisfaire. En particulier, cette thèse étudie des contraintes spécifiquement conçues pour la fouille de quasi cliques presque persistantes dans des graphes dynamiques. Notre extracteur est plusieurs ordres de grandeurs plus efficaces que les algorithmes existants se restreignant à la fouille de motifs exacts dans des relations ternaires ou à la fouille de motifs tolérants aux erreurs dans des relations binaires. Malgré ces résultats, une telle approche exhaustive ne peut souvent pas, en un temps raisonnable, tolérer tout le bruit contenu dans le jeu de données. Dans ce cas, compléter l'extraction avec une agglomération hiérarchique des motifs (qui ne tolèrent pas suffisamment de bruit) améliore la qualité des collections de motifs renvoyées
Wu, Wencen. "Bio-inspired cooperative exploration of noisy scalar fields." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/48940.
Повний текст джерелаBahri, Emna. "Amélioration des procédures adaptatives pour l'apprentissage supervisé des données réelles." Thesis, Lyon 2, 2010. http://www.theses.fr/2010LYO20089/document.
Повний текст джерелаMachine learning often overlooks various difficulties when confronted real data. Indeed, these data are generally complex, voluminous, and heterogeneous, due to the variety of sources. Among these problems, the most well known concern the sensitivity of the algorithms to noise and unbalanced data. Overcoming these problems is a real challenge to improve the effectiveness of the learning process against real data. In this thesis, we have chosen to improve adaptive procedures (boosting) that are less effective in the presence of noise or with unbalanced data.First, we are interested in robustifying Boosting against noise. Most boosting procedures have contributed greatly to improve the predictive power of classifiers in data mining, but they are prone to noisy data. In this case, two problems arise, (1) the over-fitting due to the noisy examples and (2) the decrease of convergence rate of boosting. Against these two problems, we propose AdaBoost-Hybrid, an adaptation of the Adaboost algorithm that takes into account mistakes made in all the previous iteration. Experimental results are very promising.Then, we are interested in another difficult problem, the prediction when the class is unbalanced. Thus, we propose an adaptive method based on boosted associative classification. The interest of using associations rules is allowing the focus on small groups of cases, which is well suited for unbalanced data. This method relies on 3 contributions: (1) FCP-Growth-P, a supervised algorithm for extracting class frequent itemsets, derived from FP-Growth by introducing the condition of pruning based on counter-examples to specify rules, (2) W-CARP associative classification method which aims to give results at least equivalent to those of existing approaches but in a faster manner, (3) CARBoost, a classification method that uses adaptive associative W-CARP as weak classifier. Finally, in a chapter devoted to the specific application of intrusion’s detection, we compared the results of AdaBoost-Hybrid and CARBoost to those of reference methods (data KDD Cup 99)
Ballard, Susan Patricia Art College of Fine Arts UNSW. "Out of order: explorations in digital materiality." Publisher:University of New South Wales. Art, 2008. http://handle.unsw.edu.au/1959.4/42596.
Повний текст джерелаAbboud, Yacine. "Fouille de motifs : entre accessibilité et robustesse." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0176/document.
Повний текст джерелаInformation now occupies a central place in our daily lives, it is both ubiquitous and easy to access. Yet extracting information from data is often an inaccessible process. Indeed, even though data mining methods are now accessible to all, the results of these mining are often complex to obtain and exploit for the user. Pattern mining combined with the use of constraints is a very promising direction of the literature to both improve the efficiency of the mining and make its results more apprehensible to the user. However, the combination of constraints desired by the user is often problematic because it does not always fit with the characteristics of the searched data such as noise. In this thesis, we propose two new constraints and an algorithm to overcome this issue. The robustness constraint allows to mine noisy data while preserving the added value of the contiguity constraint. The extended closedness constraint improves the apprehensibility of the set of extracted patterns while being more noise-resistant than the conventional closedness constraint. The C3Ro algorithm is a generic sequential pattern mining algorithm that integrates many constraints, including the two new constraints that we have introduced, to provide the user the most efficient mining possible while reducing the size of the set of extracted patterns. C3Ro competes with the best pattern mining algorithms in the literature in terms of execution time while consuming significantly less memory. C3Ro has been experienced in extracting competencies from web-based job postings
Quetard, Boris. "Anticipation et accumulation active d'information sensorielle dans la prise de décision en situations de vision normale et dégradée." Thesis, Université Clermont Auvergne (2017-2020), 2018. http://www.theses.fr/2018CLFAL006/document.
Повний текст джерелаDriving a vehicle in the fog requires the integration of noisy visual information with expectations about the visual road scene, in order to search for visual clues important for navigating. The visual search and identification of relevant objects can be seen as decision-making processes where sensory information is accumulated and where the expectations about the target object and its context are integrated. The accumulation of information is often modelled as a passive process. This thesis focuses on the contribution of active mechanisms integrating expectations about the target (its identity, its location) with degraded sensory information (with fog or artificial noise). We used the mouse-tracking paradigm, allowing to infer dynamic aspects of the decision-making process through a computer mouse movements. Study 1 evaluates the effect of the context for categorizing a target and suggests a trade-off between the speed and accuracy of the evidence accumulation process which can be seen as actively influencing the decision. But this study cannot directly evaluate the active collection of evidence. In Studies 2 and 3, target detection and verification are directly measured through eye movements during visual search tasks in visually degraded scenes. We manipulated the expectations about the location (Study 2) and the target’s identity (Study 3). These studies emphasize the contributions of the detection and verification processes in the accumulation of evidence toward the target present and target absent responses. In conclusion, we propose the draft of a decision-making model which integrates the dynamics between the accumulation of evidence, and the oculomotor system
Wan, Tsimhei. "Predicting optimal self-assembly of patchy colloids via simulation : an exploration of local search metaheuristics on a noisy yield landscape." Thesis, University of Bath, 2019. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.767600.
Повний текст джерелаAimon, Cassandre. "Effet de l'environnement sur les stratégies comportementales du bar Dicentrarchus labrax. Cas d'une pénurie de nourriture et d'une marée noire Food deprivation reduces social interest in the European sea bass Dicentrarchus labrax, in the Journal of Experimental Biology 222(3), February 2019." Thesis, Brest, 2019. http://www.theses.fr/2019BRES0055.
Повний текст джерелаMarine ecosystems are under a wide range of natural or anthropogenic forcings. In response to these forcings, marine organisms rely notably on their phenotypic plasticity to preserve their fitness. In this thesis, I am particularly interested in the behavioural plasticity of juvenile European sea bass in response to two environmental stressors, food deprivation and exposure to petroleum hydrocarbons. The main objective of this work is to evaluate the consequences of these disturbances through an integrative approach that assesses direct effects at the individual level, but also possible indirect impacts at the population and community levels.The behavioural tests implemented allowed the evaluation of three behavioural traits : sociability, risk-taking and exploration. From an analytical point of view, a principal component analysis was applied in order to objectify the identification of behaviours and their interpretation. Experimental results show that fasting reduces sociability and that exposure to petroleum hydrocarbons can lead to alterations in the anti-predator response. These results suggest adverse effects on the fitness of individuals with possible repercussions on ecological dynamics through altered intra- (gregarious) and inter-specific (predator/prey) relationships. This research illustrates how behavioural regulations can link the effects of environmental disturbances to multiple levels of organization, from the individual to the ecosystem
Samson, Stéphanie. "En attendant l'or. Une histoire souterraine de la colonisation française en Afrique noire. Explorations, prospections, économie minière (1850-1940)." Paris 10, 2009. http://www.theses.fr/2009PA100137.
Повний текст джерелаBambuk’s gold lured French explorers into the Upper Senegal region in the 18th century. So, why was there no Eldorado in the French African colonies south of Sahara ? This research focuses on mining investments: the failure of the Kenieba mines (mid-19th century), planed by Faidherbe, then Governor of Senegal, who was haunted by the myth of Bambuk’s gold, later the rushes of Ivory Coast, Guinea and the Congo, driven by the speculation in the British colonies and the success of the Belgian Congo, and in the 30’, the mines of Oubangui-Chari and Cameroon. The forms of the mining policy are studied through the objectives, means and methods of the administration, the use of science and techniques (cartography, geology), law reform and the relationships with companies and African gold miners. At first, military and administrators, afraid of a possible gold rush, chose a restrictive mining law. France was skeptical about the mineral wealth of Africa and specialized these colonies in agricultural products. However, bauxite and iron were found. In the 20’, Antonetti, ‘gouverneur general’ in French Equatorial Africa, favoured big business, which prospected for industrial minerals. In the 30’, a new lobby created by mining and metallurgy companies (CSMM and Comité des Forges), led by Fernand Blondel, a mining engineer, promoted Africa as a strategic place for minerals, pushing for an intervention of the state. Nevertheless, in 1939, gold and diamonds remained the main export minerals of AOF and AEF, 70% of this gold coming from traditional African mining. This was considered as a failure for the colonizing power
Eude, Thibaut. "Forage des données et formalisation des connaissances sur un accident : Le cas Deepwater Horizon." Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLEM079/document.
Повний текст джерелаData drilling, the method and means developed in this thesis, redefines the process of data extraction, the formalization of knowledge and its enrichment, particularly in the context of the elucidation of events that have not or only slightly been documented. The Deepwater Horizon disaster, the drilling platform operated for BP in the Gulf of Mexico that suffered a blowout on April 20, 2010, will be our case study for the implementation of our proof of concept for data drilling. This accident is the result of an unprecedented discrepancy between the state of the art of drilling engineers' heuristics and that of pollution response engineers. The loss of control of the MC 252-1 well is therefore an engineering failure and it will take the response party eighty-seven days to regain control of the wild well and halt the pollution. Deepwater Horizon is in this sense a case of engineering facing extreme situation, as defined by Guarnieri and Travadel.First, we propose to return to the overall concept of accident by means of an in-depth linguistic analysis presenting the semantic spaces in which the accident takes place. This makes it possible to enrich its "core meaning" and broaden the shared acceptance of its definition.Then, we bring that the literature review must be systematically supported by algorithmic assistance to process the data taking into account the available volume, the heterogeneity of the sources and the requirements of quality and relevance standards. In fact, more than eight hundred scientific articles mentioning this accident have been published to date and some twenty investigation reports, constituting our research material, have been produced. Our method demonstrates the limitations of accident models when dealing with a case like Deepwater Horizon and the urgent need to look for an appropriate way to formalize knowledge.As a result, the use of upper-level ontologies should be encouraged. The DOLCE ontology has shown its great interest in formalizing knowledge about this accident and especially in elucidating very accurately a decision-making process at a critical moment of the intervention. The population, the creation of instances, is the heart of the exploitation of ontology and its main interest, but the process is still largely manual and not without mistakes. This thesis proposes a partial answer to this problem by an original NER algorithm for the automatic population of an ontology.Finally, the study of accidents involves determining the causes and examining "socially constructed facts". This thesis presents the original plans of a "semantic pipeline" built with a series of algorithms that extract the expressed causality in a document and produce a graph that represents the "causal path" underlying the document. It is significant for scientific or industrial research to highlight the reasoning behind the findings of the investigation team. To do this, this work leverages developments in Machine Learning and Question Answering and especially the Natural Language Processing tools.As a conclusion, this thesis is a work of a fitter, an architect, which offers both a prime insight into the Deepwater Horizon case and proposes the data drilling, an original method and means to address an event, in order to uncover answers from the research material for questions that had previously escaped understanding
Vu, Hong-Son, and 武黃山. "Broad-Bandwidth Active Noise Cancellation Integrated Circuit Design Exploration Targeting at High-Performance/Low-Power for In-ear Headphones." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/96683710387480231089.
Повний текст джерела逢甲大學
電機與通訊工程博士學位學程
104
Conventional active noise control (ANC) headphones often perform well in reducing the low-frequency noise and isolating the high-frequency noise by earmuffs passively. The existing ANC systems often use high-speed digital processors to cancel out disturbing noise, which result in high power consumption for a commercial ANC headphone. While ANC headphone applications are strongly influenced by practical constraints, most previous works developing algorithms for ANC headphones are based on simplified simulations only and neglect practical limitations. This dissertation proposes a dedicated ANC circuit implementation based on the well-known adaptive filtered-x least mean square (FxLMS) algorithm for high fidelity in-ear headphones, which includes the new techniques to design the VLSI architecture that owns both the versatility and scalability. The proposed design techniques which include the proper filter length selection, low-power storage mechanism for convolution, parallel processing, and high-throughput pipelining architecture provide optimization in the view points of algorithmic, architectural, logic, and circuit levels to achieve high noise reduction performance and low-power design goals. Using those techniques, this dissertation proposes two design examples which are (1) a low-power broad-bandwidth noise cancellation VLSI circuit design based on well-known feed-forward FxLMS algorithm, and (2) a high-performance feedback active noise cancellation VLSI circuit design. The design (1) can attenuate 15 dB for broadband pink noise between 50 and 1500 Hz when operated at 20-MHz clock frequency at the costs of 84.2 k gates and power consumption of 6.59 mW only, with constraints from higher cost and more complex due to it requires two microphones from the hardware structural view point. The design (2) can achieve 15 dB noise reduction and up to 600 Hz attenuation bandwidth, while using only one microphone and is not influenced by the causality constraint. Using the TSMC 90-nm CMOS technology, the optimum operating frequencies of the both proposed designs are 20-MHz which achieve good noise reduction, high data throughput rate, and low-power consumption. The success of this chip implementation proves the correctness and practicability of the proposed design techniques.
Leavitt, Sarah Van Ness. "Exploration of infectious disease transmission dynamics using the relative probability of direct transmission between patients." Thesis, 2020. https://hdl.handle.net/2144/41503.
Повний текст джерелаBaer, Michelle M. "Clowning around : an exploration of life behind the nose." Thesis, 2008. http://spectrum.library.concordia.ca/975908/1/MR45274.pdf.
Повний текст джерелаAkilo, Olufemi David. "Exploration of an electro-magneto-responsive polymeric drug delivery system for enhanced nose-to-brain delivery." Thesis, 2016. http://hdl.handle.net/10539/21526.
Повний текст джерелаDelivering drugs to the brain for the treatment of brain diseases has been fraught with low bioavailability of drugs due to the Blood-Brain Barrier (BBB). The intranasal (IN) route of delivery has purportedly been given recognition as an alternative route of delivering drugs to the brain with improved bioavailability if the nose-to-brain option is considered. However, drugs administered through the nasal mucosa suffer some challenges such as mucocilliary clearance, enzymatic degradation, inability of a controllable drug release to give a precise dose, resulting in frequent dosing and absorption into the systemic circulation through the blood rich vessels in the mucosa, thus facing the BBB challenge. The aim of this study was to develop a novel Nano-co-Plex (NCP), a magnetic nano-carrier loaded with a therapeutic agent which is further incorporated into a nasal thermosensitive electro-responsive mucogel (TERM) for in situ gelling, for electroactuated release of the incorporated drug-loaded NCP in a controllable “on-off” pulsatile manner, which is achieved with the aid of an external electric stimulation (ES). The released drug-loaded NCP was then targeted to the brain via a direct nose-to-brain drug delivery pathway with the aid of an external magnetic field (MF) for rapid transportation. The ES was brought about by applying a 5V potential difference (PD) using electrodes on the nose and the external MF would then be applied by placing a magnetic headband on the head of the patient. In this research, the drug-loaded NCP was prepared by firstly synthesizing iron oxide nanoparticles (Magnetite) which were then coated with Polyplex; a polymeric complex fabricated employing polyvinyl alcohol (PVA), polyethyleneimine (PEI) and fIuorecein isothiocyanate (FITC). The coated magnetite was thereafter loaded with Carmustine (BCNU), an effective drug commonly used in brain tumor treatment, to formulate the BCNU-NCP. The TERM was prepared by blending a thermosensitive polymer, Pluronic F127 (F127) with mucoadhesive polymers, chitosan (CS) and hydroxypropyl methylcellulose (HPMC). Polyaniline (PANI) was included in the blend as the electo-active moiety of the formulation. Finally, the BCNU-NCP was incorporated into the gel to form a Nanogel- Composite. A Box–Behnken design model was employed for the optimization of the Nanogel Composite. TERM, BCNU-NCP and Nanogel Composite were characterized employing Thermogravimetric analysis (TGA), Superconducting Quantum Interference Device (SQUID) magnetometry, Fourier Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR), X-ray Diffractometry (XRD), Scanning Electron Microscopy (SEM), Cyclic Voltammetry (CV), Transmission Electron Microscopy (TEM), Rheological, Porositometry, Textural and Zetasize analyses. In vitro drug release, ex vivo permeation and in vivo studies were performed. The BCNU-NCP was found to be paramagnetic with a magnetization value of 61emu/g, possessing a mixture of spherical and hexagonal shaped core-shell nanoparticles of size 30-50nm with zeta potential of +32 ±2mV. The NCP displayed a high degree of crystallinity with 32% Polyplex coating. The loading capacity of NCP was 176.86μg BCNU/mg of the carrier and maximum release of 75.8% of the loaded BCNU was achieved after 24 hours. FTIR and NMR confirmed the conjugation of PVA and PEI of the Polyplex at a ratio of 1:4. Cytotoxicity of the BCNU-loaded Nano-co-Plex displayed superiority over the conventional BCNU towards human glioblastoma (HG) A170 cells. Cell studies revealed enhanced uptake and internalization of BCNU-NCP in HG A170 cells in the presence of an external MF. BCNU-NCP was found to be non-toxic to healthy brain cells. A thermally stable gel with desirable rheological and mucoadhesive properties was developed. The results revealed gelation temperature of 27.5±0.5°C with a porous morphology. Nanogel Composite possesses electroactive properties and shows response to ES and releases incorporated BCNU-NCP in an “on-off” pulsatile drug release profile upon application of a 5V PD. The in vitro release studies showed an average release of BCNU-NCP per release cycle to be 10.28%. Ex vivo permeation studies were performed using a freshly excised nasal tissue of the New Zealand white rabbit; the results showed that BCNU-NCP was able to permeate through the nasal tissue at a 6 times greater amount in the presence of a MF than in the absence of MF. BCNU concentration was found to be high in the brain and CSF of rabbit when the Nanogel Composite is intranasally administered compared to the IV injection of the conventional BCNU. Furthermore, application of the MF was found to increase the concentration of BCNU in the brain and CSF of the rabbit. The result of Field Emission Electron Probe Micro Analyzer (FE EPMA) was further used to confirm the presence of NCP in the rabbit brain tissue. Histopathological results indicated mild lesions in the nasal mucosa of the rabbit after IN administration of Nanogel Composite. The results of the in vitro, ex vivo and the in vivo proved that the Nanogel Composite is superior in delivering BCNU into the brain than the conventional drug delivery system for the treatment of brain tumor as it was able to release the therapeutic agent in a controllable manner. The MF applied aided drug to be targeted and rapidly transported to the brain via a direct nose-to-brain pathway thereby circumventing the BBB and increasing bioavailability of drug in the brain. This vehicle may also be used to deliver other similar therapeutic agents into the brain for the treatment of various brain diseases.
MB2016
Dahan, Jean-Jacques. "La démarche de découverte expérimentalement médiée par Cabri-Géomètre en mathématiques: un essai de formalisation à partir de l'analyse de démarches de résolutions de problèmes de boîtes noires." Phd thesis, 2005. http://tel.archives-ouvertes.fr/tel-00356107.
Повний текст джерелаL'analyse de la résolution d'une boîte noire particulière permet d'affiner notre modèle a priori de la démarche de découverte en y précisant le rôle de la figure (Duval), les niveaux de géométrie (praxéologies G1 et G2 de Parzysz) et leurs prolongements que nous développons (G1 et G2 informatiques), les cadres d'investigations (Millar) et la place de la preuve expérimentale (Johsua).
Les analyses des expérimentations mises en place permettent de disposer d'un modèle amélioré qui doit permettre aux enseignants d'avoir une connaissance minimale des étapes heuristiques du travail de leurs élèves, de concevoir des activités d'études et de recherches ayant des objectifs précis en liaison avec les étapes formalisées de notre modélisation et d'envisager leur possible évaluation.
Des analyses d'activités existantes avec notre grille montrent la validité du modèle étudié. Des propositions d'activités ont été construites pour favoriser l'apparition de telle ou telle phase de la recherche; elles montrent la viabilité de ce modèle dans la conception d'ingénieries didactiques générant une démarche conforme à la démarche postulée.