Дисертації з теми "Experimental trials"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 дисертацій для дослідження на тему "Experimental trials".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Matassa, Vincenzo. "Optimisation of experimental design and analysis for sugarcane variety trials /." [St. Lucia, Qld.], 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17336.pdf.
Повний текст джерелаKirvesoja, H. (Heli). "Experimental ergonomic evaluation with user trials: EEE product development procedures." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514259378.
Повний текст джерелаXu, Bo. "Predictors of treatment means for a one factor completely randomized design." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/dissertations/AAI3372284/.
Повний текст джерелаLind, Torbjörn. "Iron and zinc in infancy : results from experimental trials in Sweden and Indonesiaa." Doctoral thesis, Umeå universitet, Epidemiologi och folkhälsovetenskap, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-277.
Повний текст джерелаDhaliwal, Lesley. "Research design and effect size : a meta-analysis of mood disorder experimental trials." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54731.
Повний текст джерелаEducation, Faculty of
Educational and Counselling Psychology, and Special Education (ECPS), Department of
Graduate
Gatch, Michael B. "An Experimental Analysis of Higher-Order Stimulus Control in Humans." DigitalCommons@USU, 1990. https://digitalcommons.usu.edu/etd/6017.
Повний текст джерелаMcBride, Ali. "Evaluating Fast Track Time Analysis of Clinical Drug Trial Phases Utilizing a Quasi-Experimental Observational Study." The University of Arizona, 2007. http://hdl.handle.net/10150/624440.
Повний текст джерелаObjectives: In this paper we analyzed the time frame for oncology drugs that were designated as a fast track drug and the time transition from a phase II to phase III clinical trial completion. Methods In our study we utilized oncology drugs that were approved between the years of 2000-2006 (FDA.gov). We then analyzed the CDER data base that provided information to Fast Track drugs that have been approved within the time period as determined by the FDA selection criteria (21 CFR 312.81(a)). Under certain circumstances, the FCA may consider reviewing portions of a marketing application in advance of the complete New Drug Application (NDA) or Biologic License Application (BLA). We will evaluate fast track designated products which may also be eligible to participate in FDA’s Continuous Marketing Applications Pilot 1 or Pilot 2 programs. For our analysis, we specifically selected oncology drugs. In particular, we analyzed 32 drugs from the stated time period. Each fast track drug was then selected and analyzed for its clinical phase development time period based on news announcements during clinical trails. For each announcement we conducted an event study analysis through lexis Nexus with respect to the announcement of a clinical trial enrollment, clinical trials news (Phase I, II, III). Results: The results of our preliminary study show that there was a shorter time to development transition for the fast track oncology drugs. The oncology clinical phase transition from II to three on average lasted 12 months with a range of 2 - 29 months The average length of the phase development had to excludes 4 drugs due to the lack of information provided from the LexisNexis database. The current timeline for fats track drugs has shown a decrease in transition from clinical trials to the market. In the example of Spyrcel, the data from our study had to be excluded, there was a definitive difference in the time to approval process for the drug as compared to other standard review entities. The approvals for dasatinib, or Sprycel, for refractory CML was shown to move through the development to approval in one of the fastest timeframes in modern development. Since its first clinical study on in Gleevec-resistant patients, the medication was decided on entering an accelerated timeline. It took us just 25 months to bring Sprycel from first-in-human dosing to a regulatory submission. In contrast, the industry average for this cycle time is 6.4 years which is three times greater than the cycle time for Sprycel. Conclusions: The new Subpart H regulations state that post-marketing studies to confirm clinical benefit that would consist usually by "studies underway” at the time of accelerated approval, this has not always been the case and is not a requirement (Dagher R, Johnson J, Williams G et al). In conclusion, the accelerated approval program in oncology has been successful in making 18 different products available to patients for 22 different cancer treatment indications since the inception of the fast track program. From the current data and transition information, there is a comparative difference between the clinical phase transitions from phase II to Phase III clinical trials. However, this preliminary data needs to be further evaluated against the standard FDA review process from oncology drugs. Moreover, further studies will be needed to interpret whether the average length of oncology studies biases the value of our study.
Bergh, Anna. "Defocused CO₂ laser irradiation in the rehabilitation of horses : an experimental and clinical study /." Uppsala : Dept. of Anatomy and Physiology, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200654.pdf.
Повний текст джерелаSvensson, Jennie. "An Experimental Study to Improve the Casting Performance of Steel Grades Sensitive for Clogging." Doctoral thesis, KTH, Tillämpad processmetallurgi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-202539.
Повний текст джерелаQC 20170227
VINNOVA
Behrel, Morgan. "Investigation of kites for auxiliary ship propulsion : experimental set-up, trials, data analysis and kite specs novel identification approach." Thesis, Brest, 2017. http://www.theses.fr/2017BRES0132.
Повний текст джерелаThis study is part of the research program beyond the sea® aiming to develop kites as auxiliary propulsion devices for ships. The goal is to use the energy of the wind to save fuel and reduce harmful emissions. Such a project needs numerous developments and scientific actions, particularly to model the behavior of giant kites and associated ships. However these models must be compared to measurements to assess their validity. This study is then focus on the measurements of the interaction between kites and ships, at a limited scale in comparison to the real scope of the project. Thus measurement campaigns were carried out on a 13-meter long trawler, and on a 6-meter long experimental platform specifically designed. Another experimental campaign was also carried out onshore to assess the aerodynamic specs of the kite. Each of these three campaigns was based on a complex experimental set-up, including an automatic kite control system. In addition to provide a valuable data set for further scientific analyses, this study provided also tools which can be used by the industrial partners of the beyond the sea project®
Chagas, Gleiber da Silva. "Estudo experimental do comportamento mecÃnico de estrato Silto- Argiloso (MassapÃ) para fundaÃÃes superficiais." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=12231.
Повний текст джерелаO dimensionamento de fundaÃÃes superficiais requer definiÃÃo de forma clara e objetiva, para o solo em estudo, da capacidade de carga e a previsÃo dos recalques a que se submete a estrutura, baseando-se nas propriedades mecÃnicas obtidas por ensaios de laboratÃrio e campo. O ensaio de placa à uma das formas mais seguras para se obter essas informaÃÃes, a partir de carregamento direto, que produz, em escala reduzida, o comportamento da futura fundaÃÃo. Os ensaios realizados nesta pesquisa foram executados em trÃs etapas: caracterizaÃÃo geotÃcnica (granulometria, determinaÃÃo da massa especÃfica, limite de consistÃncia, compactaÃÃo proctor normal e Ãndice de suporte califÃrnia (ISC)); ensaios especiais de laboratÃrio (adensamento e cisalhamento); e ensaios de campo (provas de carga). O objetivo deste trabalho à avaliar a partir da realizaÃÃo de provas de carga diretas com solo na umidade natural e inundado, se previsÃes de potencial de colapso e expansÃo, realizadas a partir de ensaios edomÃtricos simples e duplos sÃo capazes de dar indicaÃÃes concordantes. Foi observado que resultados de ensaios edometricos duplos, realizados no solo silto argiloso da cidade de IcÃ, proporcionaram estimativas mais concordantes para as situaÃÃes de colapso do solo. AlÃm disso, a tÃcnica da compactaÃÃo de solos problemÃticos se mostrou adequada para minorar, ou mesmo anular, problemas relacionados ao colapso e a expansÃo do solo estudado.
The design of shallow foundations requires defining clearly and objectively to the soil under study, the load capacity and the prediction of settlements that undergoes structure, based on the mechanical properties obtained from laboratory testing and field. The plaque assay is one of the safest ways to get this information from direct loading, which produces, in reduced scale, the behavior of the Future Foundation. The tests performed in this study were performed in three steps: geotechnical characterization (particle size, density determination, consistency limits, standard Proctor compaction and California bearing ratio (ISC)); Special laboratory tests (density and shear); and field trials (load tests). The objective of this study is to evaluate the evidence from conducting direct load with soil and flooded in natural moisture, if forecasts of potential collapse and expansion, made from single and double edomÃtricos tests are able to give consistent evidence. It was observed that results of double edometricos trials, conducted in silty clay soil of the city Ico, provided more consistent estimates for situations of soil collapse. Furthermore, the technique of compression problematic soils was adequate to mitigate or even nullify, problems related to the collapse and expansion of the studied soil.
Waters, Rafael. "Energy from Ocean Waves : Full Scale Experimental Verification of a Wave Energy Converter." Doctoral thesis, Uppsala universitet, Elektricitetslära, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9404.
Повний текст джерелаMartínez, Rovira Immaculada. "Monte Carlo and experimental small-field dosimetry applied to spatially fractionated synchrotron radiotherapy techniques." Doctoral thesis, Universitat Politècnica de Catalunya, 2012. http://hdl.handle.net/10803/81470.
Повний текст джерелаBrits, Jeanette. "A framework for the use and interpretation of statistics in reading instruction / Jeanette Brits." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1678.
Повний текст джерелаBurin, Cláudia. "Tamanho de parcela e número de repetições para avaliar a massa verde de parte aérea de milheto." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/5134.
Повний текст джерелаThe present study aimed to determine the optimum plot size and number of repetitions to evaluate the fresh weight of aerial part of millet (Pennisetum glaucum (L). R. Brown) in evaluation times (Chapter I) and to determine the optimum plot size and number of repetitions to evaluate the fresh weight of aerial part of millet in times of sowing and cuts (Chapter II). Were conducted uniformity trials of 6m×4m (24m2), in the agricultural years 2012-2013 and 2013-2014, at the experimental area of the Crop Science Department of the Federal University of Santa Maria. Each trial was divided in 24 experimental units basic (UEB) with 1m×1m (1m2). The fresh weight of aerial part of plants was weighed in each UEB. At 52, 69 and 82 days after sowing were evaluated, respectively, 18, 6 and 18 trials, in the agricultural year 2012-2013 (Chapter I). In the agricultural year 2013-2014, there were three times of sowing and three fresh weight cuts in the first and third times of sowing, to evaluate the regrowth. In the second time of sowing was conducted a single cut (Chapter II). The plot size, for two agricultural years, was determined by the method of maximum curvature of the model coefficient of variation and the means compared, among evaluation times, among cuts and among times of sowing by Student s t test. The number of repetitions, for experiments on completely randomized and randomized block designs, in scenarios of combinations of i treatments (i=3, 4, ..., 50) and d minimal differences between treatments means to be detected as significant, 5% probability by Tukey test, expressed in percentage of the average of the experiment (d=10%, 12%, ..., 30%), was determined by iterative process until convergence. In the agricultural year 2012-2013, the optimum plot size to evaluate the fresh weight of aerial part of millet is 4.46m2, to the three evaluation times. To evaluate up to 50 treatments, in completely randomized and randomized block designs, four replications are sufficient to identify as significant at 5% probability, by Tukey test, differences between treatment means of 28.75% of the average experiment (Chapter I). In the agricultural year 2013-2014, the optimum plot size to evaluate the fresh weight of aerial part of millet is 4.97m2, to the three times of sowing and cuts. To evaluate up to 50 treatments, in completely randomized and randomized block designs, five replications are sufficient to identify as significant at 5% probability, by Tukey test, differences between treatment means of 28.66% of the average experiment (Chapter II).
O presente trabalho teve como objetivos determinar o tamanho de parcela e o número de repetições para avaliar a massa verde de parte aérea de milheto (Pennisetum glaucum (L). R. Brown) em épocas de avaliação (Capítulo I) e determinar o tamanho de parcela e o número de repetições para avaliar a massa verde de parte aérea de milheto em épocas de semeadura e cortes (Capítulo II). Foram realizados ensaios de uniformidade de 6m×4m (24m2), nos anos agrícolas 2012-2013 e 2013-2014, na área experimental do Departamento de Fitotecnia, na Universidade Federal de Santa Maria. Cada ensaio de uniformidade foi dividido em 24 unidades experimentais básicas (UEB) de 1m×1m (1m2). Foi pesada a massa verde de parte aérea das plantas de cada UEB. Aos 52, 69 e 82 dias após a semeadura do ano agrícola 2012-2013, foram avaliados, respectivamente 18, 6 e 18 ensaios (Capítulo I). No ano agrícola 2013-2014, foram realizadas três épocas de semeadura e três cortes de massa verde na primeira e terceira épocas de semeadura, para avaliar a rebrota. Na segunda época de semeadura foi realizado um único corte (Capítulo II). O tamanho de parcela, para os dois anos agrícolas, foi determinado por meio do método da curvatura máxima do modelo do coeficiente de variação e as comparações de médias, entre épocas de avaliação, entre cortes e entre as épocas de semeadura foram realizadas pelo teste t de Student. O número de repetições, para experimentos nos delineamentos inteiramente casualizado e blocos ao acaso, em cenários formados pelas combinações de i tratamentos (i=3, 4, ..., 50) e d diferenças mínimas entre médias de tratamentos a serem detectadas como significativas a 5% de probabilidade, pelo teste de Tukey, expressas em percentagem da média do experimento (d=10%, 12%, ..., 30%), foi determinado por processo iterativo até a convergência. No ano agrícola 2012-2013, o tamanho ótimo de parcela para avaliar a massa verde de parte aérea de milheto é de 4,46m2, para as três épocas de avaliação. Para avaliar até 50 tratamentos, nos delineamentos inteiramente casualizado e blocos ao acaso, quatro repetições são suficientes para identificar como significativas, pelo teste de Tukey, a 5% de probabilidade, diferenças entre médias de tratamentos de 28,75% da média do experimento (Capítulo I). No ano agrícola 2013-2014, o tamanho ótimo de parcela para avaliar a massa verde de parte aérea de milheto é de 4,97m2, para as três épocas de semeadura e cortes. Para avaliar até 50 tratamentos, nos delineamentos inteiramente casualizado e blocos ao acaso, cinco repetições são suficientes para identificar como significativas, pelo teste de Tukey, a 5% de probabilidade, diferenças entre médias de tratamentos de 28,66% da média do experimento (Capítulo II).
Rocha, Francisco Carlos Machado [UNIFESP]. "Revisão sistemática da literatura de estudos clínicos e experimentais sobre os efeitos antitumorais dos canabinóides." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/10062.
Повний текст джерелаObjetivo: Avaliar, através de uma revisão sistemática da literatura, os efeitos antitumorais dos canabinóides em qualquer tipo de neoplasia, utilizando como amostra seres humanos e animais de laboratório com tumores, bem como culturas de células tumorais. Método: A pesquisa incluiu as seguintes bases eletrônicas de dados: PUBMED, EMBASE, LILACS e “The Cochrane Collaboration Controlled Trials Register”. Todos os estudos publicados que envolveram os efeitos antitumorais (mecanismos celulares e moleculares) dos canabinóides foram considerados para esta revisão. Desta forma, foram levados em conta não somente ensaios clínicos (randomizados ou não) como também estudos experimentais in vivo e in vitro. A estratégia de busca bibliográfica compreendeu todas as publicações de cada base de dados até 31 de dezembro de 2009. O exame minucioso de todas as referências bibliográficas dos artigos importantes para esta revisão (incluindo artigos de revisão) foi igualmente realizado com o objetivo de selecionar artigos que não tivessem sido capturados pela estratégia de busca eletrônica. Resultados: De 3.920 artigos inicialmente identificados, 117 preencheram os critérios de inclusão para esta revisão. Todos os estudos incluídos nesta revisão sistemática foram experimentais (in vivo e/ou in vitro), excetuando-se um estudo clinico piloto fase I/II em humanos. Em todos os estudos experimentais incluídos, os canabinóides exerceram atividade antitumoral in vitro e/ou evidência antitumoral in vivo em vários modelos de células tumorais e tumores, respectivamente. As atividades antitumorais incluíram: efeitos antiproliferativos (sequestro do ciclo celular), diminuição da viabilidade e morte celular por toxicidade, apoptose, necrose, autofagia, efeitos antiangiogênicos e antimigratórios. As evidências antitumorais incluíram: diminuição do tamanho tumoral, efeitos antiangiogênicos e antimetastáticos. Adicionalmente, a maioria dos estudos descreveu que os canabinóides apresentaram seletividade na ação antitumoral em vários modelos tumorais. Desta forma, as células normais usadas como controle não foram atingidas. O fator segurança na administração dos canabinóides também foi demonstrado in vivo, em ratos com tumores marcados com células tumorais. O único estudo realizado em humanos, por sua vez, demonstrou segurança na administração intratumoral do delta-9-THC em pacientes com glioblastoma multiforme recorrente. Conclusões: Os vários canabinóides testados em múltiplos modelos de tumores apresentaram efeitos antitumorais in vitro e in vivo. Estes achados indicam que os canabinóides são compostos promissores para o tratamento das neoplasias. No entanto, pesquisas em seres humanos através de ensaios clínicos randomizados, metodologicamente bem conduzidos, devem ser realizadas para a avaliação de eficácia dos mesmos antes que eles possam ser indicados para esta finalidade. Este é o caso do delta- 9-THC e do canabidiol, que já foram testados e aprovados para uso em humanos em outras condições clínicas. Outros canabinóides, no entanto, necessitam ainda de pesquisas farmacocinéticas, farmacodinâmicas e toxicológicas antes de poderem ser testados em seres humanos.
Objective: To evaluate, through a systematic review of the literature, the antitumoral effects of cannabinoids on any type of cancer, involving both human beings and animal samples, as well as cultured tumor cells. Method: Research included the following electronic databases: PUBMED, EMBASE, LILACS and "The Cochrane Collaboration Controlled Trials Register. All published studies involving the antitumoral effects (cellular and molecular mechanisms) of cannabinoids were considered for this review. Thus, not only clinical trials (randomized or not) but experimental studies (both in vivo and in vitro) were taken into account. The bibliography search strategy included all publications of each of these databases until December 31, 2009. The scrutiny of all the references from the relevant articles for this review (which included review articles) was also performed, in order to select items that could not have been captured by the chosen electronic search strategy. Results: From 3,920 initially identified articles, 117 fulfilled the inclusion criteria for this review. All the studies included in this systematic review were experimental (in vivo and/or in vitro), except for a pilot clinical trial phase I/II involving humans. In all experimental studies included, cannabinoids exerted antitumoral activity in vitro and/or antitumoral evidence in vivo in several models of tumor cells and tumors, respectively. The antitumor activity included: antiproliferative effects (cell cycle arrest), decreased viability and cell death by toxicity, apoptosis, necrosis, autophagy, as well as antiangiogenic and antimigratory effects. Antitumoral evidence included: reduction in tumor size, antiangiogenic, and antimetastatic effects. Additionally, most of the studies described that the canabinnoids exercised selective antitumoral action in several distinct tumor models. Furthermore, normal cells used as controls were not affected. The safety factor in the cannabinoids’ administration has also been demonstrated in vivo in rats with tumors which were marked with tumor cells. The sole study in humans demonstrated safety in intratumoral administration of delta-9- THC in patients with recurrent glioblastoma multiforme. Conclusions: The various cannabinoids tested in multiple tumor models showed antitumoral effects both in vitro and in vivo. These findings indicate that cannabinoids are promising compounds for the treatment of cancer. However, methodologically well conducted research on humans through clinical trials has yet to be performed in order to evaluate their effectiveness. This is the case of delta-9-THC and cannabidiol, which have been tested and approved for use in humans in other clinical conditions. In the case of other cannabinoids, however, further pharmacokinetic as well as pharmacodynamic and toxicological studies are required before their being tested in humans.
TEDE
BV UNIFESP: Teses e dissertações
Déporte, Astrid. "Caractérisation du fonctionnement d'une hydrolienne à membrane ondulante pour la récupération de l'énergie des courants marins." Thesis, Brest, 2016. http://www.theses.fr/2016BRES0031/document.
Повний текст джерелаThis manuscript presents three approaches : analytical, experimental and numerical, to study the behavior of a flexible membrane tidal energy convertor. This technology, developed by the EEL Energy company, is based on periodic deformations of a pre-stressed flexible structure. Energy convertors, located on each side of the device, are set into motion by the wave-like motion.In the analytical model, the membrane is represented by a linear beam model at one dimension and the flow by a 3 dimensions potential fluid. The fluid forces are evaluated by the elongated body theory. Energy is dissipated all over the length of the membrane. A 20th scale experimental prototype has been designed with micro-dampers to simulate the power take-off. Trials have allowed to validate the undulating membrane energy convertor concept. A numerical model has been developed. Each element of the device is represented and the energy dissipation is done by dampers element with a damping law linear to damper velocity.Comparison of the three approaches validates their ability to represent the membrane behavior without damping. The energy dissipation applied with the analytical model is clearly different from the two other models because of the location (where the energy is dissipated) and damping law. The two others show a similar behavior and the same order of power take off repartition but value of power take off are underestimated by the numerical model. These three approaches have allowed to put forward key-parameters on which depend the behavior of the membrane and the parametric study highlights the complementarity and the advantage of developing three approaches in parallel to answer industrial optimization problems.To make the link between trials in flume tank and sea trials, a 1/6th prototype has been built. To do so, the change of scale was studied. The behavior of both prototypes is compared and differences could be explained by differences of boundary conditions and confinement effects. To evaluated membrane long-term behavior at sea, a method of aging accelerated by temperature and fatigue tests have been carried out on prototype materials samples immerged in sea water
Gravuer, Kelly. "Determinants of the introduction, naturalisation, and spread of Trifolium species in New Zealand." Master's thesis, Lincoln University. Bio-Protection and Ecology Division, 2004. http://theses.lincoln.ac.nz/public/adt-NZLIU20071015.060329/.
Повний текст джерелаBurkert, Janaina Fernandes de Medeiros. "Otimização das condições de produção da lipase por Geotrichum candidum NRRL-Y552." [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/255036.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
Made available in DSpace on 2018-08-03T14:23:26Z (GMT). No. of bitstreams: 1 Burkert_JanainaFernandesdeMedeiros_D.pdf: 9150119 bytes, checksum: 05d911513e3637048890ed7ef1eb3867 (MD5) Previous issue date: 2003
Resumo: O interesse na produção de lipases microbianas tem aumentado significativamente nas últimas décadas, devido ao seu amplo potencial de aplicações industriais, seja na indústria de alimentos como aditivos (modificação de aromas), química fina (síntese de ésteres), detergentes (hidrólise de gorduras), tratamento de efluentes (decomposição e remoção de substâncias oleosas), couro (remoção de lipídios das peles dos animais), farmacêutica e na área médica (remédios, digestivos e enzimas para diagnósticos). A produção de lipase pode ser influenciada por diferentes variáveis, como o microrganismo produtor da enzima, as fontes de carbono, nitrogênio e lipídio, as condições de aeração e agitação, o tipo do impulsor, e até mesmo a geometria do reator. Na primeira etapa deste trabalho foram realizados testes com diferentes indutores (óleo de soja, óleo de milho, óleo de girassol, óleo de canola e óleo de oliva) para produção de lipase utilizando o microrganismo Geotrichum candidum NRRL- Y552, obtendo como melhor indutor o óleo de soja. Em seguida, um estudo para padronização do inóculo foi realizado possibilitando o início da otimização do meio de cultura, em frascos agitados, obtendo como meio otimizado 3,58% de peptona e 0,64% de óleo de soja, com pH inicial de 7,0 a 30°C e 250 rpm, alcançando 16 U/mL em 48 horas de fermentação. Utilizando as condições de produção otimizadas, a enzima foi caracterizada quanto a pH ótimo, temperatura ótima e de estabilidade, a influência de sais minerais na atividade enzimática e a determinação dos parâmetros cinéticos KM e Vmáx. Seqüencialmente, com o meio de cultura otimizado, foi verificada a influência dos impulsores turbina de Rushton, hélice naval e pás inclinadas na produção da lipase em fermentadores de bancada, atingindo em tomo de 25 g/L de biomassa para todos os impulsores e 19 U/mL em 30 horas, 12 U/roL em 30 horas e 22 U/mL em 54 horas, respectivamente, de atividade lipolítica. Utilizando o agitador tipo pás inclinadas foi investigado o efeito clã agitação e aeração no processo fermentativo, sendo obtida as condições de 300 rpm e 1 vvm a 30°C como ótimas para produção da lipase, alcançando aproximadamente 22 U/mL em 54 horas de processo. Ainda foi investigado o efeito de diferentes taxas de aeração em um reator não convencional "air lift" que permitiu obter cerca de 20 U/mL de atividade lipolítica em 30 horas de fermentação, possibilitando nesta geometria de reator uma produtividade 40% maior em relação aos reatores convencionais. Estes resultados para o processo de produção da lipase foram superiores em relação aos relatados na literatura para o mesmo microrganismo
Abstract: The interest in microbial lipase production increased significantly in the last decades, because of the large potential in industrials applications such as: additives in foods (flavor modification), fine chemicals (synthesis of esters), detergents (hydrolysis of fats), waste water treatment (decomposition and removal of oily substances), leather (removal of lipids of animal skins), pharmaceutical and medical areas (remedies, digestives and enzymes for diagnostics). The lipase production can be influenced by different variables such as the microorganism, the carbon sources, nitrogen and lipid, the aeration and agitation conditions, the impeller type, and also including the geometry of the reactor. In the first stage of this work tests was carried out with different inductors (soy oil, com oil, sunflower oil, canola oil and olive oil) for lipase production by Geotrichum candidum NRRL- Y552, getting as the best inductor the soy oil. After that, a study for standardization of inoculum was carried out, making possible the beginning of the optimization of the culture medium, in shaker-flasks, getting as half optimized 3.58% of peptona and 0.64% of soy oil, with initial pH of 7,0, 30°C and 250 rpm that conditions allow reaching 16 U/mL in 48 hours of fermentation. Using the optimized conditions of production, the enzyme was characterized concerning to optimum pH, optimum temperature and stability temperature, the influence of salts in the enzymatic activity and the determination the kinetic parameters KM and Vmáx, Sequentially, with the optimized medium culture, the influence of the impellers it was verified for Rushton turbine, helix naval and pitched blade up in the production of lipase in fermenter, reaching around 25 g/L of biomass for all impellers and 19 U/mL in 30 hours, 12 U/mlL in 30 hours and 22 U/mlL in 54 hours, respectively. Using the impeller type pitched blade up the effect of the agitation and aeration in the of lipase production was investigated, being the optimum conditions 300 rpm and 1 vvm at 30°C for enzyme production, reaching approximately 21 U/mL in 54 hours of fermentation. The effect of different aeration rates in a not conventional reactor air lift was also investigated, resulting in about 20 U/mL of lipolytic activity ín 30 hours of fermentation, making possible to obtain with this geometry of reactor a larger productivity (40% greater ín comparison to the conventional reactors). These results for the process of lipase production are larger than the reported ones in the literature for the same microorganism
Doutorado
Doutor em Engenharia de Alimentos
Smith, Alison B. "Multiplicative mixed models for the analysis of multi-environment trial data /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phs64221.pdf.
Повний текст джерелаDavid, W. W. "Training Tribal Facilitators for Peacemaking in Mindanao| An Experimental Study." Thesis, Fuller Theological Seminary, School of Intercultural Studies, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13428586.
Повний текст джерелаConflicts in Mindanao can be caused by incidents such as adultery, land disputes, even jealousy within dominant clan groups. The incidents may emerge as an interpersonal conflict, but may result in wider aggression, escalating into interclan conflict when the victim’s relatives or ethnic group get involved. Though the initial conflict is interpersonal, it might affect the inter-societal level and even the international level.
The central issue that directed this research was to discover the factors influencing Mindanao tribal students who seek rido, “interclan revenge,” and to revise “Peace Generation” from Indonesia in order to implement contextual methods of “Training Tribal Students to Be Peacemakers” that uses insiders to facilitate tribal students for conflict transformation in Mindanao.
As a missionary, I have attempted to equip mature Muslim-background believers associated with Yoido Full Gospel Mission in Mindanao to become facilitators of a program of training tribal people to be peacemakers and to mobilize some to become agents for peacemaking in Mindanao.
In order to implement sustainable peace among the entire Moro ethnic group, I adapted Lederach’s conceptual framework to establish the foundation of trust or to restore trust among interclan or intertribal relationships. This process guided the research in light of historical perspectives recognizing colonial factors affecting the population in Mindanao. This research employs narrative interviews to listen to participants and develop deeper interaction regarding the issues that are verbalized in intergroup conflicts.
In order to train these Christian peace facilitators for the revised process, I chose Tablig: A Compilation of Resources for Understanding the Muslim Mindset. Over about a year and a half in three rounds of field research, I discovered factors in Peace Generation training that might be perceived differently from tribal students’ perspectives. All three of the facilitators agreed in Training Group interviews that love is always the main factor in conflict transformation. Furthermore, all three of the Tausug villagers affirmed love, justice, and God’s guidance as factors in their marital conflict transformation.
After reflection on these three research periods, I chose to step back as an outsider facilitator and trainer and to empower “voluntary insiders” and “insiders” to facilitate tribal students in peacemaker training. I have clearly separated findings—peacebuilding facilitated by one of the insiders—that are significant from ones that are not. In my analysis, my leadership has not shifted appropriately in recognition of tribal people groups, which need indigenization. Hence, it is significant to note that transforming conflicts only through scriptural studies is not feasible; it should be conducted by an insider innovator/transformer, rather than by my entrepreneurship.
Indeed, if I did not step back from being a peace facilitator and did not train insider or voluntary peace facilitators, we would not have seen the remarkable result in the lifecycle of organizational leadership transition. The main factor influencing and equipping tribal students and adults to be peacemakers, as carried out by insider facilitators, is “love and forgiveness,” as Romans 13:10 says, “therefore love is the fulfillment of the law.”
Curran, Kassie. "Consumer acceptance of omega-3 enhanced beef in surveys and retail trials." Thesis, Kansas State University, 2015. http://hdl.handle.net/2097/20413.
Повний текст джерелаAgricultural Economics
John A. Fox
This study examines consumer acceptance of omega-3 enhanced beef using data from a choice experiment and a retail trial. The retail trial was conducted in collaboration with La Vaca Meat Company, Littleton, CO which offered omega-3 enhanced beef products for sale both online and in-store. Prices were adjusted periodically, and online customers were surveyed to gather information about their purchase decisions. The choice experiment was included in an online survey conducted with a nationally representative sample of consumers. One version of the survey focused on ground beef and another focused on steak. Within each version separate treatments examined the impact of providing information about how levels of the most beneficial omega-3s could be enhanced in beef. The choice experiment evaluated how variation in meat attributes such as omega-3 content, safety, and tenderness influenced purchase decisions. Data from the choice experiment were analyzed using multinomial logit models. Results indicate that overall acceptance and willingness to pay for omega-3 enhanced beef was below that of grass-fed beef. Additional information about omega-3s increased willingness-to-pay for enhanced omega ground beef, but had no impact on willingness-to-pay for enhanced omega steak. The analysis showed significant heterogeneity in preferences, and, in particular, females had significantly higher willingness-to-pay for grass-fed ground beef than males. Average willingness-to-pay for grass-fed steak was estimated at $3.69/lb above conventionally raised product, compared to an estimated premium of $1.86/lb for enhanced omega steak. For ground beef the average premium for grass-fed product was estimated to be $1.27/lb compared to $0.79/lb for the enhanced omega product.
Junod, Valérie. "Clinical drug trials : studying the safety and efficacy of new pharmaceuticals /." Genève ; Zurich ; Bâle : Genève : Bruxelles : Schulthess ; Faculté de droit ; Bruylant, 2005. http://aleph.unisg.ch/hsgscan/hm00153347.pdf.
Повний текст джерелаGraspeuntner, Simon [Verfasser]. "The cervical microbiome in female infectious infertility : clinical trial and experimental mouse models / Simon Graspeuntner." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2017. http://d-nb.info/1142648095/34.
Повний текст джерелаJob, Sarah. "Identity-Specific Positive Psychology Intervention for Sexual Minorities: A Randomized Control Trial." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/etd/3891.
Повний текст джерелаDi, Loreto Alessandro <1985>. "Nutraceutical Value of Durum Wheat: Influence of Environment and Genotype in a Large Scale Experimental Trial." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7531/.
Повний текст джерелаYousef, Zaheer Raza. "Post-infarction left ventricular remodelling and the open artery hypothesis : an experimental model and a clinical trial." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405634.
Повний текст джерелаYabe, Shinichi. "Portal blood flow and liver regeneration in auxiliary partial orthotopic liver taransplantation - experimental study and clinical trial." Kyoto University, 2000. http://hdl.handle.net/2433/151404.
Повний текст джерелаKoeda, Tomoko, Takahiro Ando, Takayuki Inoue, Kenta Kamisaka, Shinya Tsukamoto, Takahiro Torikawa, Jun Hirasawa, Makoto Yamazaki, Kunio Ida, and Kazue Mizumura. "A trial to Evaluate Experimentally Induced Delayed Onset Muscle Soreness and Its Modulation by Vibration." Research Institute of Environmental Medicine, Nagoya University, 2003. http://hdl.handle.net/2237/7566.
Повний текст джерелаJohnston, Elizabeth Elinor. "Evaluating the health effects of a social intervention in older people using an experimental approach." Thesis, Queen's University Belfast, 2008. https://pure.qub.ac.uk/portal/en/theses/evaluating-the-health-effects-of-a-social-intervention-in-older-people-using-an-experimental-approach(f4ca1560-2946-4be8-b54b-5deb0a6fe78c).html.
Повний текст джерелаMendes, Alexandre Consul. "Analise do processo de extrusão na industria de "PET-FOOD" para a aplicação de tecnicas de controle avançado." [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/255745.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
Made available in DSpace on 2018-08-03T02:14:18Z (GMT). No. of bitstreams: 1 Mendes_AlexandreConsul_M.pdf: 28710433 bytes, checksum: dd88ab66a072eb5070a05416b953f5c6 (MD5) Previous issue date: 2003
Resumo: O trabalho a seguir apresenta as principais ferramentas necessárias para o controle do processo de extrusão baseado na densidade e umidade do produto extrusado úmido. Para facilitar a compreensão da aplicação do controle avançado, revisa-se alguns conceitos básicos da teoria clássica de controle. Devido à complexidade deste processo, orientado pela transformação bio-polimérica da matéria-prima farino-lipídico-protéica a certa umidade ao longo da extrusora, são retomados alguns conceitos de estatística, a fim de compor um modelo experimental para as principais variáveis independentes e de processo na extrusão. Estudou-se a relação estatística significativa entre as variáveis independentes: vazão de farinha, vazão de vapor, vazão de água e rotação de helicóide do extrusor e as variáveis de processo: densidade e umidade do produto extrusado úmido, temperatura de saída e pressão de saída da extrusora. Para o completo entendimentos destas relações, são correlacionados as variações dos teores de umidade, lipídios, proteínas e carboidratos da farinha a ser extrusada. Ainda como importante parâmetro industrial é realizado o balanço de energia para o processo em questão através da energia mecânica específica ('SME') e energia térmica específica ('STE'). Devido à aplicação industrial deste trabalho, o controle da densidade e umidade do produto extrusado úmido é na verdade baseado no controle da relação empírica entre a temperatura e pressão na saída da extrusora. Dessa forma, o custo de instalação e precisão, enfatizando a necessidade de repetibilidade na medida de temperatura e pressão de saída, se tomam muito mais viáveis quando os mesmos são comparados com a medida de densidade e umidade para o produto extrusado na saída da extrusora. Equipamentos para a medida precisa de densidade para produtos sólidos-úmidos aplicam princípio nuclear e para a medida de umidade são empregados instrumentos com sofisticados espectros de infravermelho associados a sistemas óticos internos. A fim de estudar-se a viabilidade deste modelo, foi realizado um planejamento composto central (4 variáveis independentes), com pontos axiais e a inclusão de alguns pontos aleatórios de interesse prático, a fim de obter-se um modelo mais robusto. Para tanto foram avaliadas três receitas típicas na indústria de rações de animais, a fim de representar-se a maioria dos produtos comerciais recomendados para cachorros e gatos. Através do conhecimento profundo das variáveis de processo, utilizou-se alguns experimentos para o entendimento do processo quanto à natureza da resposta, como a linearidade e a variação da resposta com o tempo. Estes experimentos informaram sobre o comportamento das curvas de reação para as variáveis independentes isoladamente. Atendendo a necessidade para a aplicação de estratégias de controle não lineares e/ou neurais o processo demonstrou-se com resposta em um único sentido com a perturbação, não linear e variante com o tempo. Este estudo foi comprovado pela aplicação da teoria de controle para processos lineares com perturbações lineares isoladas. Finalmente, é utilizado o conhecimento adquirido no estudo do processo de extrusão e da avaliação da curva resposta experimental das perturbações isoladas para o projeto de um algorítimo de controle baseado na estratégia de controle MIMO 2 x 2. Este controle foi testado através do controlador neuro-adaptativo 'Model Free Adaptive' (MFA), demonstrando resultados preliminares satisfatórios para o controle simultâneo da temperatura e pressão de saída de um extrusor de eixo simples, empregando como variáveis manipulativas a proporção de vapor / água e a vazão de farinha de alimentação respectivamente para as variáveis de processo citadas
Abstract: The present study informs about the main features of extrusion control processes, based on product-wet density and moisture. To comprehend the study, some background of the classic control theory is provided. The process complexity, provided by formation of a bio-polymer from carbohydrate-lipid-protein raw materials, requires analysis using statistical concepts to build an experimental model for the principal extrusion process variables. Significant statistical relationships were evaluated between the following independent variables: meal feed rate, steam feed rate, water feed rate and extruder screw speed; and dependent variables: wet product density and moisture, extruder die temperature and die pressure. The process energy and mass balance were described using the Specific Mechanical Energy ('SME') and Specific Thermal Energy ('STE') concepts. To facilitate the industrial application of this study, the wet density and moisture control is evaluated by an experimental empirical relationship between die temperature and die pressure. Die temperature and die pressure measurements are more feasible when compared with wet product density and moisture measurements due to ease of installation and measurement precision. Suitable equipment for the wet-solid product density measurements apply the nuclear principle, where safety is a concern; and moisture measurements use sophisticated devices with any combination of infrared and optical systems. In order to evaluate the model application, a box experimental design was used with four independent variables, star points and some random points resulting from extrusion operation experience. Three typical dry recipes used in the pet food industry were tested, representing the majority of retail products for dogs and cats. Applying the knowledge of extrusion process variables, several experiments were run to understand the process responses, such as linearity and control parameters. These experiments showed the influence of isolated independent variables to the dependent variables. The process was characterized by presenting a one way, non-linearity and time varying response, suitable for non-linear and neural controllers. Classic control theory was applied to evaluate each perturbation. The knowledge gained from an extrusion process and experimental response curve analysis from isolated perturbation was applied to build a control algorithm based on MIMO 2 X 2 control strategy. This model was tested by the neural-adaptive ' Model Free Adaptive' (MFA) controller. Initial satisfactory results were observed from the simultaneous control of die temperature and die pressure on a single screw extruder, using as manipulative variables the ratio of steam / water and the meal feed rate respectively
Mestrado
Mestre em Engenharia de Alimentos
Mawdsley, Stephen Edward. "Fighting polio : selling the gamma globulin field trials, 1950-1953." Thesis, University of Cambridge, 2012. https://www.repository.cam.ac.uk/handle/1810/252270.
Повний текст джерелаCury, Alvaro Hafiz. "Efeito potencial de uma goma de mascar experimental com cimento de ionômero de vidro em sua formulação." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/25/25148/tde-08012013-111620/.
Повний текст джерелаThe aim of this study is to evaluate the potential effect of a chewing gum containing experimental Glass Ionomer Cement (GIC) in preventing caries. Methodology: fifteen children / adolescents aged between 06 and 19 years old in need of treatment and prevention of dental caries were selected. After formal agreement to take part in the research, the participants were divided randomly into three groups: Group A: experimental gum; Group B: neutral gum (placebo); Group C: conventional noninvasive sealing. To assess the potential preventive effect on caries, repeated clinical assessments were carried out, as well as a collection of stimulated saliva for analysis of pH, flow, buffering capacity and fluoride concentration. In order to verify the presence of GIC in the areas of pits and fissures, inspections on the occlusal surfaces of molars and / or premolars were conduced by thorough clinical examination, photographic documentation with conventional light, fluorescent light (Quantitative Light Fluorescence) and scanning electron microscopy, using replicas with addition silicone. Additionally, volunteers and researchs staff were submitted to extensive questionnaires, aiming to evaluate the acceptance of chewing gum as a vehicle for therapeutic purposes. All analyses were conducted by independent researchers (blind review). Results: neither clinical and photographic assessments, nor analyses of replicas in scanning electron microscopy showed any kind of sealing pits and fissures of molars and / or premolars. During the specified period, any kind of remineralization was identified with the use of fluorescent light. Nevertheless, laboratory results showed favorable signs in the process of remineralization of dental tissues. Nonparametric statistical test Kruskal-Wallis indicated a significant increase in flow and buffering capacity of saliva after the use of chewing gum, and a significant increase in salivary fluoride concentration for groups A and C (p<0.05). As a general rule, groups A and B showed good responsiveness. Conclusion: the results showed significant evidence that gums containing GIC present a significant remineralizing potential. This attribute implies the realization of further researches making use of this vehicle for fluoride release, especially if we consider its commercial appeal, the average age of regular users, the frequency and mean duration of a chewing gum in the oral cavity. Works in which the subjects have a higher frequency of use (and not just a single instance of use), a longer observation time (longitudinal study), in different concentrations and presentations (different types of fluoride), demonstrate that the use of chewing gum as a vehicle for fluoride release into the oral cavity is a promising alternative for the prevention of tooth decay in a potential group of patients/consumers.
Marshall, Samuel David. "Sloping convection : an experimental investigation in a baroclinic annulus with topography." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:ca9cfaf5-49e8-4e30-b93a-65c27d1c8a15.
Повний текст джерелаArnroth, Cornelia. "A study of protein aggregation processes using Dynamic Light Scattering : Validation of the technique and experimental trial with an active pharmaceutical ingredient." Thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422862.
Повний текст джерелаPronger, II Gregory Emery. "Convergent Validity Between the Questions About Behavioral Function (QABF) Questionnaire, Trial-Based Functional Analysis, and Traditional Functional Analysis for Adults with a Dual Diagnosis in a Day Program Setting." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/theses/1705.
Повний текст джерелаThöle, Heinrich. "Ansätze zur statistischen Auswertung von On-Farm-Experimenten mit georeferenzierten Daten." Doctoral thesis, Humboldt-Universität zu Berlin, Landwirtschaftlich-Gärtnerische Fakultät, 2010. http://dx.doi.org/10.18452/16232.
Повний текст джерелаA pendulum sensor (Crop-Meter) measures cereal aboveground biomass in order to apply nitrogen (N) fertilizers site-specifically on heterogeneous agricultural fields. In on-farm trials, common N application practice (constant) was compared to site-specific (variable) N application with the sensor to assess grain yields as response. Unlike the classic design of small-plot trials, cereal crop heterogeneity was explicitly desired to use the Crop-Meter. Simultaneously, spatial yield data provided pseudo-replications and possible autocorrelation. Therefore, two approaches were selected for statistical analysis. In the first approach, yield data were post-stratified on the basis of biomass measures to confine total biomass variability. For each stratum, spatial co-variance structures were assumed for residuals (spatial models) opposed to the assumption of non-correlated residuals (null model). Spatial models were selected as best statistical models. Very often, yield differences were not significant when selecting spatial models in contrast to null models. However, this was not due to different stratifications and stratum-dependent N savings. In the second approach, trend models were fitted for total yield datasets with covariates in addition to spatial models. For each on-farm trial, distinct combinations of trend and spatial models were selected. Most mean differences were not significant despite site-specific N reduction (7…24 kg N ha-1). These approaches provide basics to derive profound methods for analysis of on-farm trials with spatial data.
Morais, Jos? Haroldo Cavalcante de. "Evolu??es nas modelagens de substratos artificiais (metamateriais) com pr?ticas experimentais em antenas de microfita." Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/20857.
Повний текст джерелаApproved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-07-06T21:46:11Z (GMT) No. of bitstreams: 1 JoseHaroldoCavalcanteDeMorais_TESE.pdf: 8218875 bytes, checksum: 74cb32467161f10131b623d5e12e6c43 (MD5)
Made available in DSpace on 2016-07-06T21:46:11Z (GMT). No. of bitstreams: 1 JoseHaroldoCavalcanteDeMorais_TESE.pdf: 8218875 bytes, checksum: 74cb32467161f10131b623d5e12e6c43 (MD5) Previous issue date: 2015-12-01
Esse trabalho tem como objetivo apresentar configura??es de substratos diel?tricos inovadores projetados e fabricados a partir de estruturas metamateriais. Para isso, s?o avaliados diversos fatores que podem influenciar no seu desempenho. A princ?pio, foi feito um levantamento bibliogr?fico a respeito dos temas, que est?o relacionados com as pesquisas sobre: materiais diel?tricos, metamateriais e interferometria ?ptica. S?o estudados, pesquisados e desenvolvidos dois projetos experimentais propostos, que comprovam a efici?ncia de m?todos, para se alcan?ar a permeabilidade magn?tica negativa na forma??o de metamateriais. O primeiro projeto ? a produ??o de uma nova estrutura, com u anel ressoador triangular equilateral (Split Equilateral Triangle Resonator - SETR). O segundo projeto: aplica os princ?pios da interferometria ?ptica, especialmente, com o interfer?metro de Fabry-Perot. T?cnicas para obten??o dos dispositivos que complementam a placa metamaterial como substrato foram pesquisadas na literatura e exemplificadas principalmente por meio de simula??es e medi??es. Foram feitas compara??es, simula??es e medi??es de estruturas convencionais e especiais. As experi?ncias se concentram nas evolu??es e modelagens de substratos metamateriais com aplica??es em antenas de microfita. As melhorias de alguns par?metros de desempenho de antenas tamb?m s?o relatadas. As simula??es das antenas foram feitas nos programas computacionais comerciais. Os resultados medidos foram obtidos com um analisador vetorial de redes da Rhode and Schwarz modelo ZVB 14.
Bonte, Bruno. "Modélisation et simulation de l’interdépendance entre l’objet, l’observateur et le modèle de l’objet dans la Triade de Minsky. Application à la surveillance épidémiologique en santé animale." Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20173/document.
Повний текст джерелаThe spread of a disease at national or international scale isn't a reproducible experiment. If experiment is not reproducible, the usual concept of model validation has no statistical meaning because it would involve the comparison between model behaviour and system behaviour.We use Marvin Minsky's definition of model: « to an observer B, an object A* is a model of an object A to the extent that B can use A* to answer questions that interest him about A ». The tree objects A, B and A* are the triad of Minsky. We propose to use the Theory of Modelling and Simulation (TMS) to model and simulate the triad seen as a dynamic system composed of the objects A, B and A*. We hence can answer questions about the use of A* and the impact it has on A.We apply this framework to a triad of Minsky in epidemiological surveillance in animal health. An epidemics (object A) is observed and controlled by a surveillance system and a control system (observer B) and an epidemiological model (model A*) is used to evaluate the control measures
Biermann, Jeanette S. "Improving Cognition in Normally Aging Older Adults: A Randomized Controlled Trial of Mindfulness Meditation (Samatha) as a Treatment for Attentional Inhibitory Deficits." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1310147941.
Повний текст джерелаHajji, Mohammed Saïd. "Etude comparative de l'association hydrophobe en solution aqueuse de tensioactifs anioniques et cationiques et de divers alcane-diols et alcane-triols par mesures des masses volumiques, de la diffusion élastique et quasi-élastique de la lumière et des." Paris 13, 1987. http://www.theses.fr/1987PA132016.
Повний текст джерелаGravråkmo, Halvar. "Buoy Geometry, Size and Hydrodynamics for Power Take Off Device for Point Absorber Linear Wave Energy Converter." Doctoral thesis, Uppsala universitet, Elektricitetslära, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220344.
Повний текст джерелаMears, Mark G. "An inter-laboratory investigation of ANSI standard fitting protocols, sample size, subject and experimenter gender, and trial on the real-ear attenuation of two types of earplugs." Thesis, This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-08252008-161851/.
Повний текст джерелаUrbain, Paul Verfasser], and Hans-Konrad [Akademischer Betreuer] [Biesalski. "Nutritional status and its impact on outcome in patients undergoing allogeneic haematopoietic cell transplantation and an experimental trial to improve the supply of a specific micronutrient / Paul Urbain. Betreuer: Hans-Konrad Biesalski." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2012. http://d-nb.info/1027353525/34.
Повний текст джерелаLindroth, [formerly Tyrberg] Simon. "Buoy and Generator Interaction with Ocean Waves : Studies of a Wave Energy Conversion System." Doctoral thesis, Uppsala universitet, Elektricitetslära, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160085.
Повний текст джерелаChopin, Stéphanie. "Chimie du dianion C60 2- : accès à de nouveaux dérivés fonctionnels du fullerène C60 : application à la synthèse de dyades et triades, et études de leurs propriétés." Doctoral thesis, Universitat Autònoma de Barcelona, 2004. http://hdl.handle.net/10803/3191.
Повний текст джерела- des dihydrofullerènes C60(CH2CO2R)2 (R = Me, Et). Des cellules photovoltaïques à base de ces dérivés et de MEH-PPV en réseaux interpénétrés montrent de bonnes performances, assez proches de celles obtenues lorsque l'accepteur est le PCBM ;
- des dihydrofullerènes fonctionnels dissymétriques C60RR'. Les synthèses correspondantes reposent sur l'exploitation, jusqu'alors non réalisée dans ce but, du mécanisme réactionnel (Kadish-Fukuzumi) de la réaction entre C602- et divers dérivés halogénés ;
- un fullerène diol, issu de dérivés du pentaérythritol. Les bons rendements obtenus pour cette synthèse font de ce fullerène diol un nouveau synthon de choix en chimie du fullerène C60.
A partir de ce fullerène diol, de nouvelles dyades et triades ont été obtenues, l'entité électro-donneur étant le motif tétrathiafulvalène ou l'anion perchlorotriphénylméthyle. Les propriétés physico-chimiques de ces assemblages covalents donneur-accepteur ont été étudiées (spectroscopies UV-Vis, fluorescence, RPE ; électrochimie ; photophysique).
New functionalized [60]fullerene derivatives have been synthesized starting from C602- anion, following the procedure previously developed in our Laboratory :
- dihydrofullerenes C60(CH2CO2R)2 (R = Me, Et). Solar cells have been built using a mixture of these compounds and MEH-PPV in interpenetrating network and they exhibit good photovoltaic characteristics, which are close to those obtained when the acceptor is PCBM ;
- functionalized dissymmetric dihydrofullerenes C60RR'. The corresponding syntheses lie upon a new interpretation of the Kadish-Fukuzumi mechanism, so far unexplored in this way, associated with the reaction between C602- and various halogeno derivatives ;
- a fullerene diol, issued from pentaerythritol derivatives. Thanks to good yields observed in this synthesis, this fullerene diol appears to be a new promising building block in fullerene chemistry.
Starting from the latter diol, new C60-based dyads and triads have been obtained, the electron donor moiety being the tetrathiafulvalene core or the perchlorotriphenylmethyl anion. The physico-chemical properties of these donor-acceptor covalent assemblies have been studied (UV-Vis, fluorescence, ESR spectroscopic methods ; electrochemistry ; photophysics).
Barsotti, Vanessa. "Recherche et caractérisation de microorganismes dans les compartiments géologiques profonds." Phd thesis, Bordeaux 1, 2011. http://tel.archives-ouvertes.fr/tel-00688631.
Повний текст джерелаPaciência, Luan Pires. "Avaliação dos instrumentos de mensuração de competências socioemocionais no contexto escolar." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/12/12138/tde-29112016-163645/.
Повний текст джерелаThis dissertation aims to examine faking behaviour in personality assessments at schools. Two approaches that create low-stakes environments are investigated: information spreading about non-cognitive skills and their impact on well-being and social progress and the fact that teachers would receive individual students\' answers. Using a CRT technique with 2853 students from 10 São Paulo state public schools, we find that students are capable to fake their answers and these two approaches turn them more motivated to engage in faking. Moreover, we show that a warning about untruthful answers attached to the questionnaire imposes a cost, discouraging faking behaviour
Hellyer, William N. "Assessment of Benthic Macroinvertebrate Community Impairment from High-Aluminum Acid Mine Drainage in Middleton Run, Ohio, USA and the Impact of Ingested Aluminum on Crayfish Growth." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1399465953.
Повний текст джерелаJansen, Kirstin. "Stable Isotopes and Metabolite Profiles as Physiological Markers for the Drought Stress Sensitivity in Douglas-Fir Provenances (Pseudotsuga menziesii (MIRB.) FRANCO)." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19617.
Повний текст джерелаIn Central Europe, more frequent periods of dry and hot weather are expected in the future with economic losses in the forestry sector. Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) is discussed as a timber species alternative to the economically important but drought-sensitive spruce (Picea abies (L.) H. Karst.). Two subspecies, the coastal (FDC) and the interior Douglas-fir (FDI), are native to an extensive natural range in North America, offering a great potential for the selection of productive and drought tolerant provenances. Our goal was to investigate the drought response of different Douglas-fir provenances on the morphological and physiological level, as well as the mechanisms underlying drought resistance or susceptibility. A provenance trial in southwestern Germany established in 1958 allowed the study of 50-year-old Douglas-fir trees of diverse provenances along a height gradient. Under controlled conditions, we simulated the effects of a heat wave on young trees of two provenances. We analyzed carbon and oxygen stable isotopic composition, leaf gas exchange, changes in metabolism and tree growth. FDC from humid regions responded to drought with strong growth decline and a medium to strong stomatal closure, supported by enhanced instantaneous photoprotection. FDC from regions with very dry summer conditions showed a small growth decline and anisohydric regulation of stomatal conductance under drought, supported by high levels of osmotic adjustment. High monoterpene emissions might contribute to the drought resistance. FDI from an arid region showed high assimilation rates, low growth potential and a high antioxidant, photoprotective, drought and heat protective potential. The provenances differ greatly in their dry reaction and their protective mechanisms. The cultivation of drought resistant crops will be beneficial at sites predicted to accumulate arid summer periods.