Дисертації з теми "Existence and multiplicity results"
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Fialho, João Manuel Ferrão. "Existence, localization and multiplicity results for nonlinear and functional." Doctoral thesis, Universidade de Évora, 2012. http://hdl.handle.net/10174/15248.
Повний текст джерелаTian, Rushun. "Existence and Multiplicity Results on Standing Wave Solutions of Some Coupled Nonlinear Schrodinger Equations." DigitalCommons@USU, 2013. https://digitalcommons.usu.edu/etd/1484.
Повний текст джерелаHuang, Lirong. "Multiplicity results for some classes of Schrödinger-Poisson systems." Doctoral thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/12867.
Повний текст джерелаIn this thesis, we study the existence and multiplicity of solutions of the following class of Schr odinger-Poisson systems: u + u + l(x) u = (x; u) in R3; = l(x)u2 in R3; where l 2 L2(R3) or l 2 L1(R3). And we consider that the nonlinearity satis es the following three kinds of cases: (i) a subcritical exponent with (x; u) = k(x)jujp2u + h(x)u (4 p < 2 ) under an inde nite case; (ii) a general inde nite nonlinearity with (x; u) = k(x)g(u) + h(x)u; (iii) a critical growth exponent with (x; u) = k(x)juj2 2u + h(x)jujq2u (2 q < 2 ). It is worth mentioning that the thesis contains three main innovations except overcoming several di culties, which are generated by the systems themselves. First, as an unknown referee said in his report, we are the rst authors concerning the existence of multiple positive solutions for Schr odinger- Poisson systems with an inde nite nonlinearity. Second, we nd an interesting phenomenon in Chapter 2 and Chapter 3 that we do not need the condition R R3 k(x)ep 1dx < 0 with an inde nite noncoercive case, where e1 is the rst eigenfunction of +id in H1(R3) with weight function h. A similar condition has been shown to be a su cient and necessary condition to the existence of positive solutions for semilinear elliptic equations with inde nite nonlinearity for a bounded domain (see e.g. Alama-Tarantello, Calc. Var. PDE 1 (1993), 439{475), or to be a su cient condition to the existence of positive solutions for semilinear elliptic equations with inde nite nonlinearity in RN (see e.g. Costa-Tehrani, Calc. Var. PDE 13 (2001), 159{189). Moreover, the process used in this case can be applied to study other aspects of the Schr odinger-Poisson systems and it gives a way to study the Kirchho system and quasilinear Schr odinger system. Finally, to get sign changing solutions in Chapter 5, we follow the spirit of Hirano-Shioji, Proc. Roy. Soc. Edinburgh Sect. A 137 (2007), 333, but the procedure is simpler than that they have proposed in their paper.
Nesta tese, estudamos a existência e a multiplicidade de soluções da seguinte classe de sistemas denominada de Schr odinger-Poisson: u + u + l(x) u = (x; u) in R3; = l(x)u2 in R3; onde l 2 L2(R3) ou l 2 L1(R3). Consideram-se não-linearidades que satisfazem um dos seguintes casos: (i) potências que envolvem um expoente sub-cr tico, da forma (x; u) = k(x)jujp2u + h(x)u, (4 p < 2 ), sendo k uma função com sinal indefinido e h uma função positiva; (ii) caso geral de uma não-linearidade indefi nida, da forma (x; u) = k(x)g(u) + h(x)u, sendo k uma função com sinal indefinido e h uma função positiva; (iii) potências que envolvem o expoente crí tico, da forma (x; u) = k(x)juj2 2u + h(x)jujq2u (2 q < 2 ). Convém salientar que esta tese tem três principais inovações, as quais ultrapassam dificuldades geradas pela natureza dos problemas estudados. Primeiro, como um relator anónimo referiu, este é o primeiro trabalho em que se trata a existência de várias soluções de sistemas de Schrödinger- Poisson com não-linearidade indefinida. Segundo, neste estudo encontrou-se um fen ómeno interessante, ver Capítulos 2 e 3, nomeadamente, não ser necess ária a condição R3 k(x)ep 1dx < 0 no caso indefinido e não-coercivo, sendo e1 a função associada ao primeiro valor próprio de + id em H1(R3) com peso h. Note-se que foi demonstrado que uma condi cão semelhante e condição necessária e suficiente na existência de solu cões positivas para equações elíticas semilineares com não-linearidades indefinidas em domínios limitados (ver e.g. Alama-Tarantello, Calc. Var. PDE 1 (1993), 439{475), ou ser uma condição suficiente na existência de soluções positivas para equações elíticas semilineares com não-linearidades indefinidas em RN (see e.g. Costa-Tehrani, Calc. Var. PDE 13 (2001), 159{189). Adicionalmente, o método utilizado pode ser utilizado para estudar outros aspetos dos sistemas de Schrodinger-Poisson, permite também estudar sistemas de Kirchho e sistemas de Schrodinger quasilineares. Por m, para obter soluções com mudança de sinal no Cap. 5, segue se a ideia de Hirano-Shioji, Proc. Roy. Soc. Edinburgh Sect. A 137 (2007), 333, mas o método utilizado é uma versão simplificada do método apresentado no artigo referido.
Woodward, Christopher Thomas. "Multiplicity-free Hamiltonian actions and existence of invariant Kähler structure." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/38408.
Повний текст джерелаGadam, Sudhasree. "Existence and Multiplicity of Solutions for Semilinear Elliptic Boundary Value Problems." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc332520/.
Повний текст джерелаGUARNOTTA, Umberto. "EXISTENCE RESULTS FOR SINGULAR CONVECTIVE ELLIPTIC PROBLEMS." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/524941.
Повний текст джерелаZhang, Yanping. "Existence and multiplicity of positive solutions in semilinear elliptic boundary value problems." Thesis, Heriot-Watt University, 2003. http://hdl.handle.net/10399/414.
Повний текст джерелаMurillo, Kelly Patricia. "Existence results for elliptic equations with singular terms." Doctoral thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/9888.
Повний текст джерелаEsta dissertação estuda em detalhe três problemas elípticos: (I) uma classe de equações que envolve o operador Laplaciano, um termo singular e nãolinearidade com o exponente crítico de Sobolev, (II) uma classe de equações com singularidade dupla, o expoente crítico de Hardy-Sobolev e um termo côncavo e (III) uma classe de equações em forma divergente, que envolve um termo singular, um operador do tipo Leray-Lions, e uma função definida nos espaços de Lorentz. As não-linearidades consideradas nos problemas (I) e (II), apresentam dificuldades adicionais, tais como uma singularidade forte no ponto zero (de modo que um "blow-up" pode ocorrer) e a falta de compacidade, devido à presença do exponente crítico de Sobolev (problema (I)) e Hardy-Sobolev (problema (II)). Pela singularidade existente no problema (III), a definição padrão de solução fraca pode não fazer sentido, por isso, é introduzida uma noção especial de solução fraca em subconjuntos abertos do domínio. Métodos variacionais e técnicas da Teoria de Pontos Críticos são usados para provar a existência de soluções nos dois primeiros problemas. No problema (I), são usadas uma combinação adequada de técnicas de Nehari, o princípio variacional de Ekeland, métodos de minimax, um argumento de translação e estimativas integrais do nível de energia. Neste caso, demonstramos a existência de (pelo menos) quatro soluções não triviais onde pelo menos uma delas muda de sinal. No problema (II), usando o método de concentração de compacidade e o teorema de passagem de montanha, demostramos a existência de pelo menos duas soluções positivas e pelo menos um par de soluções com mudança de sinal. A abordagem do problema (III) combina um resultado de surjectividade para operadores monótonos, coercivos e radialmente contínuos com propriedades especiais do operador de tipo Leray- Lions. Demonstramos assim a existência de pelo menos, uma solução no espaço de Lorentz e obtemos uma estimativa para esta solução.
This dissertation study mainly three elliptical problems: (I) a class of equations, which involves the Laplacian operator, a singular term and a nonlinearity with the critical Sobolev exponent, (II) a class of equations with double singularity, the critical Hardy-Sobolev exponent and a concave term and (III) a class of equations in divergent form, which involves a singular term, a Leray-Lions operator, and a function defined on Lorentz spaces. The nonlinearities considered in problems (I) and (II), bring additional difficulties which, as the strong singularity at zero (so blow-up may occur) and the lack of compactness due to the presence of a Sobolev critical exponent (problem (I)) and a Hardy-Sobolev critical exponent (problem (II)). In problem (III), the singularity implies that the standard definition of weak solution may not make sense. Therefore is necessary to introduce a special notion of weak solution on open subsets of the domain. Variational methods and Critical Point Theory techniques are used to prove the existence of solutions in the two first problems. In problem (I), our method combines Nehari's techniques, Ekeland's variational principle, minimax methods, a translation argument and integral estimates of the energy level. In this case, we prove the existence of (at least) four nontrivial solutions where at least one of them is sign-changing. In problem (II), we prove the existence of at least two positive solutions and a pair of sign-changing solutions, using the concentration-compactness method and the mountain pass theorem. The approach in problem (III) combines a surjectivity result for monotone, coercive and radially continuous operators with special properties of Leray-Lions operators. We prove the existence of at least one solution in a Lorentz space and obtain an estimative for the solution.
Hata, Kazuya. "Multiplicity Results of Periodic Solutions for Two Classes of Nonlinear Problems." DigitalCommons@USU, 2014. https://digitalcommons.usu.edu/etd/4030.
Повний текст джерелаVelichkov, Bozhidar. "Existence and regularity results for some shape optimization problems." Doctoral thesis, Scuola Normale Superiore, 2013. http://hdl.handle.net/11384/85690.
Повний текст джерелаThe shape optimization problems naturally appear in engineering and biology. They aim to answer questions as:-What a perfect wing may look like?-How to minimize the resistance of a moving object in a gas or a fluid?-How to build a rod of maximal rigidity?-What is the behaviour of a system of cells?The shape optimization appears also in physics, mainly in electrodynamics and in the systems presenting both classical and quantum mechanics behaviour. For explicit examples and furtheraccount on the applications of the shape optimization we refer to the books [20] and [69]. Here we deal with the theoretical mathematical aspects of the shape optimization, concerning existence of optimal sets and their regularity. In all the practical situations above, the shape of the object in study is determined by a functional depending on the solution of a given partial differential equation. We will sometimes refer to this function as a state function.The simplest state functions are provided by solutions of the equations−∆w = 1 and −∆u = λu,which usually represent the torsion rigidity and the oscillation modes of a given object. Thus our study will be concentrated mainly on the situations, in which these state functions appear,i.e. when the optimality is intended with respect to energy and spectral functionals. [20] D. Bucur, G. Buttazzo: Variational Methods in Shape Optimization Problems. Progress in Nonlinear Differential Equations 65, Birkhauser Verlag, Basel (2005).[69] A. Henrot, M. Pierre: Variation et optimisation de formes: une analyse geometrique. Springer-Berlag, Berlin, 2005
Velichkov, Bozhidar. "Existence and regularity results for some shape optimization problems." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENM088/document.
Повний текст джерелаThe shape optimization problems naturally appear in engineering and biology. They aim to answer questions as:-What a perfect wing may look like?-How to minimize the resistance of a moving object in a gas or a fluid?-How to build a rod of maximal rigidity?-What is the behaviour of a system of cells?The shape optimization appears also in physics, mainly in electrodynamics and in the systems presenting both classical and quantum mechanics behaviour. For explicit examples and furtheraccount on the applications of the shape optimization we refer to the books [20] and [69]. Here we deal with the theoretical mathematical aspects of the shape optimization, concerning existence of optimal sets and their regularity. In all the practical situations above, the shape of the object in study is determined by a functional depending on the solution of a given partial differential equation. We will sometimes refer to this function as a state function.The simplest state functions are provided by solutions of the equations−∆w = 1 and −∆u = λu,which usually represent the torsion rigidity and the oscillation modes of a given object. Thus our study will be concentrated mainly on the situations, in which these state functions appear,i.e. when the optimality is intended with respect to energy and spectral functionals. [20] D. Bucur, G. Buttazzo: Variational Methods in Shape Optimization Problems. Progress in Nonlinear Differential Equations 65, Birkhauser Verlag, Basel (2005).[69] A. Henrot, M. Pierre: Variation et optimisation de formes: une analyse geometrique. Springer-Berlag, Berlin, 2005
Khoury, Michael John Jr. "Multiplicity One Results and Explicit Formulas for Quasi-Split p-adic Unitary Groups." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1218567821.
Повний текст джерелаPlatino, Vincenzo. "Existence, regularity and testability results in economic models with externalities." Doctoral thesis, Universita degli studi di Salerno, 2012. http://hdl.handle.net/10556/1312.
Повний текст джерелаThis thesis deals with economic models in the presence of externalities. The thesis consists of three chapters. In chapter 1, we consider a general model of production economies with consumption and production externalities. That is, the choices of all agents (households and firms) affect individual consumption sets, individual preferences and production technologies. Describing equlibria in terms of first order conditions and market clearing conditions, and using a homotopy, under differentiability and boundary conditions, we prove the non-emptiness and compactness of the set of competitive equilibria with consumptions and prices strictly positive. In chapter 2 we consider a general model of private ownership economies with consumption and production externalities. Showing by an example that basic assumptions are not enough to guarantee a regularity result in the space of initial endowments, we provide sufficient conditions for the regularity in the space of endowments and transformation functions. In chapter 3 we study the testability implications of public versus private consumption in collective models of group consumption. To the contrary at the previous literature, we find that assumptions regarding the public or private nature of specific goods do have testability implications, even if one only observes the aggregate group consumption. In fact, these testability implications apply as soon as the analysis includes three goods and four observations. In our opinion, our revealed preference approach obtains stronger testability conclusions because it focuses on conditions which involve personalized prices and personalized quantities, although we do not require that personalized prices and personalized quantities are observable. [edited by author]
VIII n.s.
Juárez, Hurtado Elard. "Existence and multiplicity of solutions to a class of elliptic problems involving operators with variable exponent." Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/8838.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
We study the existence and multiplicity of nontrivial solutions for two classes of elliptic problems. The first problem covers a general class of operators with variables exponents where the nonlinearitv has subcritical growth. The second problem is a nonlocal elliptic problem where the nonlinearitv has critical growth. ... continua
Neste trabalho estudamos a existência e multiplicidade de soluções não triviais para duas classes de problemas elípticos. O primeiro problema elíptico que estudamos abrange uma classe geral de operadores com expoentes variáveis onde a não linearidade possui crescimento subcrítico. O segundo problema trata de uma equação não local envolvendo uma ampla classe de operadores onde a não linearidade possui crescimento sublinear/superlinear, mais um termo com crescimento crítico. ... continua
Manicom, Gray Thomas. "Existence results for a class of semi-linear initial value problems." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/63288.
Повний текст джерелаDissertation (MSc)--University of Pretoria, 2017.
Mathematics and Applied Mathematics
MSc
Unrestricted
Sauer, Martin [Verfasser]. "Existence and Uniqueness Results for Randomly Forced Generalized Newtonian Fluids / Martin Sauer." München : Verlag Dr. Hut, 2013. http://d-nb.info/1034003283/34.
Повний текст джерелаNerlich, Alexander [Verfasser]. "Adding randomness to nonlinear semigroups: existence, uniqueness and asymptotic results / Alexander Nerlich." Ulm : Universität Ulm, 2018. http://d-nb.info/1171900880/34.
Повний текст джерелаLuo, Yongming [Verfasser]. "Existence and Regularity Results of a Ferroelectric Phase-Field Model / Yongming Luo." Kassel : Universitätsbibliothek Kassel, 2019. http://d-nb.info/1201508339/34.
Повний текст джерелаMeinert, Melissa [Verfasser]. "Partial differential equations on fractals. Existence, Uniqueness and Approximation results / Melissa Meinert." Bielefeld : Universitätsbibliothek Bielefeld, 2020. http://d-nb.info/1214806538/34.
Повний текст джерелаHebestreit, Niklas [Verfasser], Christiane [Gutachter] Tammer, and Franco [Gutachter] Giannessi. "Existence results for vector quasi-variational problems / Niklas Hebestreit ; Gutachter: Christiane Tammer, Franco Giannessi." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2020. http://d-nb.info/122159981X/34.
Повний текст джерелаAraújo, Yane Lísley Ramos. "Existence results for some elliptic equations involving the fractional Laplacian operator and critical growth." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/9252.
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In this work we prove some results of existence and multiplicity of solutions for equations of the type ( ) u + V (x)u = f(x; u) in RN; where 0 < < 1, N 2 , ( ) denotes the fractional Laplacian, V : RN ! R is a continuous function that satisfy suitable conditions and f : RN R ! R is a continuous function that may have critical growth in the sense of the Trudinger-Moser inequality or in the sense of the critical Sobolev exponent. In order to obtain our results we use variational methods combined with a version of the Concentration-Compactness Principle due to Lions.
Neste trabalho provamos alguns resultados de existência e multiplicidade de soluções para equações do tipo ( ) u + V (x)u = f(x; u) em RN; onde 0 < < 1, N 2 , ( ) denota o Laplaciano fracionário, V : RN ! R é uma função contínua que satisfaz adequadas condições e f : RN R ! R é uma função cont ínua que pode ter crescimento crítico no sentido da desigualdade de Trudinger-Moser ou no sentido do expoente crítico de Sobolev. A m de obter nossos resultados usamos métodos variacionais combinados com uma versão do Princípio de Concentração- Compacidade devido à Lions.
Cabarrubias, Bituin C. "Existence, uniqueness and homogenization results for a class of nonlinear PDE in perforated domains." Rouen, 2012. http://www.theses.fr/2012ROUES046.
Повний текст джерелаGalstyan, Anahit. "Existence and Number of Global Solutions to Model Nonlinear Partial Differential Equations." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1115841126.
Повний текст джерелаYusuf, Owolabi. "On models of Kirchhoff Equations with damping terms: existence results and asymptotic behaviour of solutions." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29370.
Повний текст джерелаMONTANARI, Piera. "Local and Global Existence results for the Characteristic Problem for Linear and Semi-linear Wave Equations." Doctoral thesis, Università degli studi di Ferrara, 2010. http://hdl.handle.net/11392/2389334.
Повний текст джерелаAzizieh, Céline. "A priori estimates, continuation methods and existence results for positive solutions of p-Laplace eauqations and systems." Doctoral thesis, Universite Libre de Bruxelles, 2001. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211660.
Повний текст джерелаMazzoleni, Dario [Verfasser], Aldo [Akademischer Betreuer] Pratelli, Dorin [Akademischer Betreuer] Bucur, and Giuseppe [Akademischer Betreuer] Buttazzo. "Existence and regularity results for solutions of spectral problems / Dario Mazzoleni. Gutachter: Aldo Pratelli ; Dorin Bucur ; Giuseppe Buttazzo." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2014. http://d-nb.info/1065270380/34.
Повний текст джерелаLuo, Tingjian. "Existence non existence et multiplicité d'ondes stationnaires normalisées pour quelques équations non linéaires elliptiques." Phd thesis, Université de Franche-Comté, 2013. http://tel.archives-ouvertes.fr/tel-01061670.
Повний текст джерелаHauser, Carlos [Verfasser], and W. [Akademischer Betreuer] Reichel. "Existence Results and A Priori Bounds for Positive Solutions of Discrete Nonlinear Elliptic Equations / Carlos Hauser ; Betreuer: W. Reichel." Karlsruhe : KIT-Bibliothek, 2019. http://d-nb.info/1190178923/34.
Повний текст джерелаHerán, Andreas [Verfasser], Jens [Akademischer Betreuer] Habermann, and Jens [Gutachter] Habermann. "Existence and Regularity Results for Parabolic Problems on Metric Measure Spaces / Andreas Herán ; Gutachter: Jens Habermann ; Betreuer: Jens Habermann." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1218785721/34.
Повний текст джерелаSchätzler, Leah [Verfasser], Frank [Akademischer Betreuer] Duzaar, and Frank [Gutachter] Duzaar. "Existence and Stability Results for Nonlinear and Doubly Nonlinear Evolutionary Problems / Leah Schätzler ; Gutachter: Frank Duzaar ; Betreuer: Frank Duzaar." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1216704287/34.
Повний текст джерелаPiovano, Paulo. "Evolution and Regularity Results for Epitaxially Strained Thin Films and Material Voids." Research Showcase @ CMU, 2012. http://repository.cmu.edu/dissertations/96.
Повний текст джерелаPalmieri, Alessandro [Verfasser], Michael [Akademischer Betreuer] Reissig, Michael [Gutachter] Reissig, and Vladimir [Gutachter] Georgiev. "Global in time existence and blow-up results for a semilinear wave equation with scale-invariant damping and mass / Alessandro Palmieri ; Gutachter: Michael Reissig, Vladimir Georgiev ; Betreuer: Michael Reissig." Freiberg : Technische Universität Bergakademie Freiberg, 2018. http://d-nb.info/1226100945/34.
Повний текст джерелаAl, Zohbi Maryam. "Contributions to the existence, uniqueness, and contraction of the solutions to some evolutionary partial differential equations." Thesis, Compiègne, 2021. http://www.theses.fr/2021COMP2646.
Повний текст джерелаIn this thesis, we are mainly interested in the theoretical and numerical study of certain equations that describe the dynamics of dislocation densities. Dislocations are microscopic defects in materials, which move under the effect of an external stress. As a first work, we prove a global in time existence result of a discontinuous solution to a diagonal hyperbolic system, which is not necessarily strictly hyperbolic, in one space dimension. Then in another work, we broaden our scope by proving a similar result to a non-linear eikonal system, which is in fact a generalization of the hyperbolic system studied first. We also prove the existence and uniqueness of a continuous solution to the eikonal system. After that, we study this system numerically in a third work through proposing a finite difference scheme approximating it, of which we prove the convergence to the continuous problem, strengthening our outcomes with some numerical simulations. On a different direction, we were enthused by the theory of differential contraction to evolutionary equations. By introducing a new distance, we create a new family of contracting positive solutions to the evolutionary p-Laplacian equation
Tavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.
Повний текст джерелаThe Human Immunodeficiency Virus (HIV) is the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a disease which has a global distribution, and it is estimated that there are currently at least 36.9 million people infected with the virus. During the replication cycle, HIV promotes several changes in the physiology of the host cell to promote their survival and enhance replication. The fast progression of HIV-1 in humans and animal models is closely linked to the function of an accessory protein Nef. Among several actions of Nef, one is the most important is the down-regulation of proteins from the immune response, such as the CD4 receptor. It is known that this action causes CD4 degradation in lysosome, but the molecular mechanisms are still incompletely understood. Nef forms a tripartite complex with the cytosolic tail of the CD4 and adapter protein 2 (AP-2) in clathrin-coated vesicles, inducing CD4 internalization and lysosome degradation. Previous research has demonstrated that CD4 target to lysosomes by Nef involves targeting of this receptor to multivesicular bodies (MVBs) pathway by an atypical mechanism because, although not need charging ubiquitination, depends on the proteins from ESCRTs (Endosomal Sorting Complexes Required for Transport) machinery and the action of Alix, an accessory protein ESCRT machinery. It has been reported that Nef interacts with subunits of AP- 1, AP-2, AP-3 complexes and Nef does not appear to interact with AP-4 and AP-5 subunits. However, the role of Nef interaction with AP-1 or AP-3 in CD4 down-regulation is poorly understood. Furthermore, AP-1, AP-2 and AP-3 are potentially heterogeneous due to the existence of multiple subunits isoforms encoded by different genes. However, there are few studies to demonstrate if the different combinations of APs isoforms are form and if they have distinct functional properties. This study aim to identify and characterize cellular factors involved on CD4 down-modulation induced by Nef from HIV-1. More specifically, this study aimed to characterize the involvement of AP-1 complex in the down-regulation of CD4 by Nef HIV-1 through the functional study of the two isoforms of ?-adaptins, AP-1 subunits. By pull-down technique, we showed that Nef is able to interact with ?2. In addition, our data from immunoblots indicated that ?2- adaptin, not ?1-adaptin, is required in Nef-mediated targeting of CD4 to lysosomes and the ?2 participation in this process is conserved by Nef from different viral strains. Furthermore, by flow cytometry assay, ?2 depletion, but not ?1 depletion, compromises the reduction of surface CD4 levels induced by Nef. Immunofluorescence microscopy analysis also revealed that ?2 depletion impairs the redistribution of CD4 by Nef to juxtanuclear region, resulting in CD4 accumulation in primary endosomes. Knockdown of ?1A, another subunit of AP-1, resulted in decreased cellular levels of ?1 and ?2 and, compromising the efficient CD4 degradation by Nef. Moreover, upon artificially stabilizing ESCRT-I in early endosomes, via overexpression of HRS, internalized CD4 accumulates in enlarged HRS-GFP positive endosomes, where co-localize with ?2. Together, the results indicate that ?2-adaptin is a molecule that is essential for CD4 targeting by Nef to ESCRT/MVB pathway, being an important protein in the endo-lysosomal system. Furthermore, the results indicate that ?-adaptins isoforms not only have different functions, but also seem to compose AP-1 complex with distinct cell functions, and only the AP-1 variant comprising ?2, but not ?1, acts in the CD4 down-regulation induced by Nef. These studies contribute to a better understanding on the molecular mechanisms involved in Nef activities, which may also help to improve the understanding of the HIV pathogenesis and the related syndrome. In addition, this work contributes with the understanding of primordial process regulation on intracellular trafficking of transmembrane proteins.
Baldelli, Laura. "Existence and multiplicity results for nonlinear elliptic problems." Doctoral thesis, 2022. http://hdl.handle.net/2158/1261959.
Повний текст джерелаFeltrin, Guglielmo. "Positive solutions to indefinite problems: a topological approach." Doctoral thesis, SISSA, 2016. http://hdl.handle.net/2318/1655560.
Повний текст джерелаCheng, Yi-Hsin, and 鄭益新. "Existence, multiplicity of positive solutions for elliptic equations." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/42781816877433940597.
Повний текст джерела國立高雄大學
應用數學系博士班
103
In this thesis, we study a class of indefinite semilinear elliptic equations and the Kirchhoff type equations by using the variational methods to obtain the existence and multiplicity of positive solutions. Roughly speaking, we use the mountain pass theorem, the Palais - Smale theory and study properties of the Nehari manifold to investigate the existence and multiplicity.
Tsing-san, Hsu, and 許清山. "Existence and Multiplicity of Solutions of Semilinear Elliptic Equations." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/10411383007821343383.
Повний текст джерелаWu, Tsung-fang, and 吳宗芳. "Existence and Multiplicity of Positive Solutions of Semilinear Elliptic Equations." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/72879607002399242158.
Повний текст джерелаShih, Yi-Wen, and 施逸文. "Existence and Multiplicity of Solutions for Semi-linear Elliptic Equations." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/18903138654509963764.
Повний текст джерела國立交通大學
應用數學系
87
In part 1 we study the problem of symmetry-breaking of positive symmetric solutions of a semi-linear elliptic equation on finite cylinders with mixed type boundary conditions in two dimentions. Taking the length as a bifurcation parameter, we prove that there are asymmetric bifurcations at certain critical numbers, and obtain some global results. In part 2 we consider some semi-linear elliptic equations with asymptotic linear non-linearity and show the existence, uniqueness, and asymptotic behavior of these solutions.
Chan, Justin. "Asymptotic existence results on specific graph decompositions." Thesis, 2010. http://hdl.handle.net/1828/2909.
Повний текст джерелаMou, Libin H. "Some existence and uniqueness results of harmonic maps." Thesis, 1990. http://hdl.handle.net/1911/16374.
Повний текст джерелаXu, Jia-Ren, and 許嘉仁. "Existence results of capillary surfaces over convex domains." Thesis, 1989. http://ndltd.ncl.edu.tw/handle/47886333637563213405.
Повний текст джерела"Ergodic control of multidimensional diffusions I. : the existence results." Laboratory for Information and Decision Systems, Massachusetts Institute of Technology], 1986. http://hdl.handle.net/1721.1/2951.
Повний текст джерела謝宗憲. "Some existence results for soluations of traveling wave type." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/31120718744331384489.
Повний текст джерелаChen, Show-Ching, and 陳秀青. "EXISTENCE RESULTS FOR HAMMERSTEIN INTEGRAL EQUATIONS AND RELATED TOPICS." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/99734197373023885880.
Повний текст джерела國立台北師範學院
數理教育研究所
90
Abstract We shall provide conditions on non-positive function f (t, u), the Hammerstein integral equation and the weighted Hammerstein integral equation have at least one solution.
BAI, FENG-MENG, and 白豐銘. "Existence and multiplicity of positive radial solutions for semilinear elliptic equations in annular domains." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/31271202693393080477.
Повний текст джерелаLin, Ya-Ping, and 林雅萍. "Some existence results for steady states of reaction-diffusion systems." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/93457131788327469250.
Повний текст джерела國立彰化師範大學
數學系所
94
Abstract In this thesis, we are interested in the existence of steady states of reaction-di.usion systems with skew-gradient structure. We use two di.erent types of variational arguments to study the existence of steady states. In addition, we obtain a standing wave solution, by making use of ordered methods for quasi-monotone systems.
YU, HUI-ZHEN, and 余慧真. "Existence results of strong solutions for certain quasilinear elliptic problems." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/27518013844424526130.
Повний текст джерела