Дисертації з теми "Evolution of developmental systems"
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Maitland, Kathleen M. "Information systems evolution." Thesis, Open University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289003.
Повний текст джерелаRyan, Patricia A. "A general model for structural processing in cultural and developmental systems." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1115764.
Повний текст джерелаDepartment of Anthropology
Nnatuanya, Ifechukwu. "Evolution of living information systems development." Thesis, Brunel University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412796.
Повний текст джерелаMaad, Johanne. "Selection and Floral Evolution in Platanthera bifolia and P. chlorantha (Orchidaceae)." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5226-4/.
Повний текст джерелаMarques, Pita Manuel Arturo. "Aitana : a developmental cognitive artifact to explore the evolution of conceptual representations of cellular automata-based complex systems." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/24904.
Повний текст джерелаHudson, Corey M. "Informatic approaches to evolutionary systems biology." Thesis, University of Missouri - Columbia, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3577951.
Повний текст джерелаThe sheer complexity of evolutionary systems biology requires us to develop more sophisticated tools for analysis, as well as more probing and biologically relevant representations of the data. My research has focused on three aspects of evolutionary systems biology. I ask whether a gene’s position in the human metabolic network affects the degree to which natural selection prunes variation in that gene. Using a novel orthology inference tool that uses both sequence similarity and gene synteny, I inferred orthologous groups of genes for the full genomes of 8 mammals. With these orthologs, I estimated the selective constraint (the ratio of non-synonymous to synonymous nucleotide substitutions) on 1190 (or 80.2%) of the genes in the metabolic network using a maximum likelihood model of codon evolution and compared this value to the betweenness centrality of each enzyme (a measure of that enzyme’s relative global position in the network). Second, I have focused on the evolution of metabolic systems in the presence of gene and genome duplication. I show that increases in a particular gene’s copy number are correlated with limiting metabolic flux in the reaction associated with that gene. Finally, I have investigated the proliferative cell programs present in 6 different cancers (breast, colorectal, gastrointestinal, lung, oral squamous and prostate cancers). I found an overabundance of genes that share expression between cancer and embryonic tissue and that these genes form modular units within regulatory, proteininteraction, and metabolic networks. This despite the fact that these genes, as well as the proteins they encode and reactions they catalyze show little overlap among cancers, suggesting parallel independent reversion to an embryonic pattern of gene expression.
Alhaj, Hussen Kutaiba. "Developmental architecture of human lymphopoiesis." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC308.
Повний текст джерелаThe standard model of hematopoiesis proposes that hematopoietic differentiation is a stepwise bifurcation process. The first separation downstream of hematopoietic stem cells will segregate mutipotent progenitors into common lymphoid and myeloid progenitors. In human many evidences support the idea that human hematopoietic organization doesn't follow the classical model, but the question was not concluded and need for further investigation. Due to limited access to primary bone marrow samples and lack of appropriate in vivo model human studies face many difficulties. In this work, we used a xenogeneic model of human fetal hematopoiesis in immune-deficient mice to dissect the early stages of lymphoid development. This model relies on the injection of UCB CD34+ cells into NSG mice. Flow cytometry analysis and gene expression profiling of humanized mice BM populations revealed that this model faithfully reproduces human fetal hematopoiesis. Combining in vitro differentiation assays to molecular studies and genetic approaches, we show that fetal human lymphopoiesis displays a dual organization, split into an ancestral CD127+ CLP-like population devoid o myeloid potential that differentiate preferentially into follicular B cells and ILC3s, and into a previously undescribed CD127- population mainly dedicated to the generation of T, marginal zone B, NK, and ILC1s We also provide evidence that Early Lymphoid Progenitors emerge independently from multipotent developmental intermediates referred to as lympho-mono'dendritic progenitors. These results confirm that human hematopoiesis doesn't follow the standard model of hematopoietic differentiation established in the mouse
Monzón, Sandoval Jimena. "Networks and the evolution of complex phenotypes in mammalian systems." Thesis, University of Bath, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683544.
Повний текст джерелаAnderson, Ingrid Anna. "The role of developmental constraint in mating-system evolution in Leavenworthia a quantitative genetic analysis /." [Bloomington, Ind.] : Indiana University, 2005. http://wwwlib.umi.com/dissertations/fullcit/3204293.
Повний текст джерелаSource: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0033. Adviser: Lynda F. Delph. "Title from dissertation home page (viewed Feb. 9, 2007)."
Mainville, Sebastien. "The International System and Its Environment: Modern Evolutionary, Physiological and Developmental Perspectives on Change in World Politics." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1468866930.
Повний текст джерелаOlson, Jeffrey L. "The Evolution of Urban-Rural Space." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1376926850.
Повний текст джерелаKushnir, Alexandra Roma Larisa. "Permeability development and evolution in volcanic systems : insights from nature and laboratory experiments." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2006/document.
Повний текст джерелаThe transition from effusive to explosive behaviour at silicic volcanoes is, in part, governed by how efficiently gas overpressures are dissipated from the volcanic plumbing. Efficient gas release is associated with effusive eruptions while inadequate outgassing contributes to explosive processes. One approach to assessing the facility of gas escape is by considering how permeability develops and evolves in the magma column and surrounding edifice. Here, I appraise the role of post-emplacement changes to microstructure in edifice-forming basaltic andesites from Merapi (Indonesia). The permeability of these rocks is dominantly crack-controlled and while these features exert important controls on gas escape through the edifice, they do not represent the escape pathways available to gas within ascending magma. To avoid the influence of postemplacement microstructure, I investigate the development and evolution of permeable networks in magmas by deforming initially impermeable two-phase magmas in simple shear. This is done in a Paterson apparatus at viscosities and shear strain rates appropriate to upper conduits in stratovolcanoes. Permeability development is confirmed in situ and develops at moderate to high shear strain rates (> 4.5 × 10⁻⁴ s⁻¹). At very high strain rates (> 5 × 10⁻⁴ s⁻¹) the magma behaves in a brittle manner and gas egress is slow, facilitated by the interconnection of short, Mode I fractures. At moderate shear strain rates (< 5 × 10⁻⁴ s⁻¹), the magma displays both brittle and viscous behaviour and permeability develops at high strain; gas escape is rapid owing to long, well-developed, sample-length Mode I fractures. Mode I fractures are ideally oriented for outgassing of the central conduit and, critically, accommodate little deformation until they are rotated into the direction of shear, making them long-lived outgassing features that may favour volcanic effusion
Phaneuf, Patrick. "ALE Analytics| A Software Pipeline and Web Platform for the Analysis of Microbial Genomic Data from Adaptive Laboratory Evolution Experiments." Thesis, University of California, San Diego, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10242571.
Повний текст джерелаAdaptive Laboratory Evolution (ALE) methodologies are used for studying microbial adaptive mutations that optimize host metabolism. The Systems Biology Research Group (SBRG) at the University of California, San Diego, has implemented high-throughput ALE experiment automation that enables the group to expand their experimental evolutions to scales previously infeasible with manual workflows. The data generated by the high-throughput automation now requires a post-processing, content management and analysis framework that can operate on the same scale. We developed a software system which solves the SBRG's specific ALE big data to knowledge challenges. The software system is comprised of a post-processing protocol for quality control, a software framework and database for data consolidation and a web platform named ALE Analytics for report generation and automated key mutation analysis. The automated key mutation analysis is evaluated against published ALE experiment key mutation results from the SBRG and maintains an average recall of 89.6% and an average precision of 71.2%. The consolidation of all ALE experiments into a unified resource has enabled the development of web applications that compare key mutations across multiple experiments. These features find the genomic regions rph, hns/tdk, rpoB, rpoC and pykF mutated in more than one ALE experiment published by the SBRG. We reason that leveraging this software system relieves the bottleneck in ALE experiment analysis and generates new data mining opportunities for research in understanding system-level mechanisms that govern adaptive evolution.
Lieberman, Tami Danielle. "Genomic insights into bacterial adaptation during infection." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11312.
Повний текст джерелаColes, Timothy Edward. "The evolution of urban retail systems in Germany, 1848 to 1914 : an historical-geographical perspective." Thesis, University of Exeter, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307313.
Повний текст джерелаPorter, William Ruger. "Physiological Implications of Dinosaur Cephalic Vascular Systems." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1426861885.
Повний текст джерелаDunningham, Jonathan P. "Long-term evolution of normal fault systems : controls on the development and evolution of extensional structures in the neotectonic Kenyan Rift, East Africa." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/13744.
Повний текст джерелаSakamoto, Akiko. "Employment, skills and tripartite relations : the evolution of skill development systems in Japan and Singapore." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/10019277/.
Повний текст джерелаSomavarapu, Sashi K. (Sashi Kanth). "System dynamics approach to understand the role of information technology in the evolution of next generation integrated product development systems." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33419.
Повний текст джерелаIncludes bibliographical references (p. 96-97).
For the automotive industry, to be competitive in the market place has to devise many strategies. Some of the prominent strategies include and are not limited to, reduction of development costs by moving in-house work to its suppliers, reduction of PD cycle time by mimicking some of the industry's successful PD processes. Some companies are also devising some complex strategies like Zero-Prototype development using computer aided prototyping and testing, currently prevalent in the aerospace and naval industries, and more recently making a move into the Lean PD systems and processes to avoid waste and increase efficiency. However, to introduce such lean PD systems, with reduced PD cycle time, into a complex organization with many internally developed IT systems, processes and tools is a huge challenge. The organization needs to adapt to these lean environments not just structurally but also culturally. To design a lean PD organization (system) the decision makers have to foresee and understand how the system of systems may react to the change before they are implemented and/or executed. In the past couple of decades IT systems have been a primary enabler for PD work flow processes.
(cont.) However, IT systems are so engraved in some PD organizations that they have turned into an engineering process mechanism. Also, some of the IT systems have served more than their life expectancy and in some cases cannot be decommissioned because these systems are so tightly coupled with the business processes. An understanding of the internal system dynamics of these deeply engraved IT systems in the PD life cycle will help the automotive industry executives (decision makers) and IT systems architects to make the right decision when designing and deploying the new PD systems or processes. This study provides an overview of how IT tools have evolved in the automotive industry. Extensive research was conducted to understand the different system dynamics tools used in industry - specifically in automotive product development and the software development areas. The study concludes with an explanation of how system dynamics tools can be used as a program planning and management tool.
by Sashi K. Somavarapu.
S.M.
Jabangwe, Ronald. "Software Quality Evaluation for Evolving Systems in Distributed Development Environments." Doctoral thesis, Blekinge Tekniska Högskola, Institutionen för programvaruteknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-00613.
Повний текст джерелаAstrop, Timothy I. Mr. "The Evolutionary Dynamics of Sexual Systems in Deep Time: An Integrated Biological and Paleontological Approach." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1404706993.
Повний текст джерелаAram, Michael, and Gustaf Neumann. "Multilayered analysis of co-development of business information systems." Springer London, 2015. http://dx.doi.org/10.1186/s13174-015-0030-8.
Повний текст джерелаJohn, Meenu Mary. "Design Methods and Processes for ML/DL models." Licentiate thesis, Malmö universitet, Institutionen för datavetenskap och medieteknik (DVMT), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-45026.
Повний текст джерелаStückemann, Thomas. "Technikentwicklung als reflexiver Modernisierungsprozeß." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2000. http://nbn-resolving.de/urn:nbn:de:swb:14-995268987156-46791.
Повний текст джерелаThere are several means to analyse the intrinsic connection of technological development and social evolution in sociology today. The thesis examines technology and its development as part of social evolution from a system-theoretical point of view. Using this approach, terms like "technology" and "social evolution" are reformulated. "Technology" is a particular type of border of social systems, using the mode of causality in observing its environment; thus Technology is defined as the fixation of causal expectations. "Social evolution" is a social systems' structural change by the selection and reinforcement of variations, creating a singular history. In terms of sociology, any technological development is part of a wider developing social context. This is visualized by confronting the terms "progress" and "modernization"; both being concepts of sociology as well as of debates on technology and social development. By using technology, by giving way to innovation, and by limiting the use of technology, a given society tries to monitor and influence its own evolution. The thesis shows that these attempts become more complex, but not necessarily more effective. The fundamental properties of any evolution cannot be annulated --- the social evolution always remains unpredictable, even when evolutionary theories allow reflexive observations. In contrast to its predecessors the modern society constitutes a type of technology which is highly independent of any given social context. But this freedom is risky. Contextualizations and decision-makings imply a higher degree of reflexivity. In the case of technological development, both determinations and options increase at the same time. What is complex in technological development is its social, not its mere technical side. Any reflexive debate on technology has to reflect technology as a social issue
Bauner, David. "Towards a sustainable automotive industry : experiences from the development of emission control systems." Doctoral thesis, KTH, Industriell dynamik, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4630.
Повний текст джерелаSedan mitten av 1970-talet har utsläppen av kolmonoxid, kolväten och kväveoxider från bensindrivna personbilar reducerats genom samordnad utveckling av lagstiftning och kommersiell introduktion av katalytisk avgasrening, som nu är en del av hundratals miljoner bilar, lastbilar och bussar över hela jorden. Denna avhandling är en disaggregerad studie av den i det närmaste globala introduktionen av katalytisk avgasrening för fordon, som åtgärd för att minska lokala luftföroreningar. Introduktionen av ”trevägskatalysatorn” för bensinbilar studeras i fyra länder. Pågående innovation för dieselavgasrening studeras. Teknisk förändring analyseras med avseende på innovationsprocessen, innovationssystemet och dess respektive intressenter. Resultaten används för att analysera konsekvenser för styrmedel för att åtgärda miljöproblem i vardande. Fordonskatalys är ett exempel på en miljömotiverad innovation, inklusive problemdefinition, lagkrav, företagens marknadsstrategier och marknadspåverkan, innovation, utbud och urval, tekniköverföring, storskalig spridning samt den fortlöpande ömsesidiga utvecklingen av teknik och policy för att reducera emissioner. Gemensamma nämnare för exempel på lyckosamma introduktionsprocesser är en inkluderande dialog kring etappvisa lagkrav, internationell konkurrens, stöd och samarbete i internationella nätverk samt en tydlig opinion för förändring. Introduktionen av trevägskatalysatorn var och är komplex och beroende av lokal kontext och regionala villkor. Kommande ”globala” teknikförändringar måste utvecklas med en förståelse för varje enskild nation eller marknad och dess specifika barriärer och drivkrafter för miljömotiverad innovation. Givet intressenter och tekniska utmaningar i olika teknologiska regimer med potential att reducera klimatförändringar är ökad bränsleeffektivisering och introduktion av s.k. plug-in-hybrider möjliga utvecklingsvägar för hållbar mobilitet.
Desde los años 70 y adelante, la contribución a la polución atmosférica de emisiones de monóxido de carbono, hidrocarburos y óxidos de nitrógeno proveniente de la combustión de los autos a gasolina, ha sido mitigado, por co-evolución entre regulación e introducción comercial de sistemas catalíticos de control de emisiones. Esos sistemas ahora forman parte de cientos de millones de autos, camiones y buses en todo el mundo. La presente tesis es un estudio desagregado de la introducción cerca de global de sistemas de control de emisiones catalíticos, como medida para reducir la contaminación atmosférica local. Se examina el proceso de introducción del convertidor catalítico “de tres vías” para autos a gasolina en cuatro países. Se estudia la innovación presente en el área de sistemas de control de emisiones de motores diesel. El cambio tecnológico es analizado viendo el proceso y el sistema de innovación y los distintos grupos de interés. Los resultados se usan para analizar las implicaciones en cuanto a innovación y política de regulación para enfrentar los desafíos medioambientales actuales. Catálisis automotriz es un ejemplo de innovación motivado ambientalmente, incluyendo definición del problema, regulación pública, estratégicas corporativas dentro y fuera de mercado, variedad, selección, transferencia de tecnología, difusión masiva y la coevolución continuo entre política de reducción de emisiones y desarrollo tecnológico. Denominaciones comunes para innovaciones exitosas, tecnológicas o de mercado, son un diálogo dinámico sobre planes de regulación estructurados en etapas, competición internacional, apoyo y coordinación de redes internacionales, y opinión local beneficiario. La introducción global del catalizador de tres vías fue compleja y altamente relacionada con el contexto local y condiciones locales, sugiriendo que estrategias “globales” de innovación y regulación para tratar los desafíos de hoy y mañana deben ser diseñados con entendimiento de factores locales a favor y en contra para innovación ambientalmente motivado. Dado los grupos de interés, los desafíos tecnológicos y las trayectorias presentes en el área de mitigación del cambio climático, se concluye que el aumento de uso eficiente de combustible y la introducción de vehículos híbridos enchufables (plug- in) son alternativas viables para el transporte sustentable.
(japanese) 1970年代の中頃から今日に至るまで,先進国においては,自動車触媒技術の導入と規制との相互作用によって、ガソリン乗用車から排出される一酸化炭素CO,炭化水素HC,窒素酸化物NOxによる大気汚染への寄与率は減少している。現在では、この自動車触媒はディーゼル乗用車、トラックやバスなどを含めて何億台もの自動車で使われている。 この論文は,各地域での大気汚染を解決する手段としての触媒の地球規模での導入に関する調査研究である。ガソリン乗用車への三元触媒導入の過程を4か国比較で行うと共に,現在取り組まれているディーゼル機関の排出ガス制御についても研究した。これらの例の技術革新について、その内容を、技術革新に係る利害関係者(ステークスホルダー)の観点から技術の変革について分析した。これらの結果から,将来の環境問題に対応するためのイノベーションと規制に関する政策への示唆を行なった。 自動車用触媒は,問題定義,規制,市場原理に基づくないしは市場原理に基づかない戦略,開発,多様性,選択,技術移転,技術普及,そして今もなお進化する排出ガス削減に関する規制(政策)と技術開発との相乗効果,等々を含んだ「環境保護に起因する技術革新」の良い例である。 技術革新、および普及の成功例に共通していることは, 1. 構造的かつ段階的な「目標へのロードマップ」を巡る相方向の会話, 2. 国際競争力, 3. 国際的ネットワークによるサポート, 4. 地域社会に支持された意見, 等が挙げられる。 三元触媒の導入はほぼ全世界に及ぶが,その過程は複雑で、地域(国)の事情に強く依存する。つまり、現在または未来の、各国(地域的)または地球規模の問題に焦点を当てた「世界的」技術革新や規制戦略は、地域よって異なる障害の存在や、環境保護の視点に立った技術革新を推進する潜在力への理解なしには成り立たないことを意味するのである。 気候変動を緩和するための様々な技術体系からの技術的挑戦および関係者(ステークスホルダー)の意見を考慮すると,燃費向上とプラグイン・ハイブリッドの導入が,交通部門における持続可能な発展への道のりであると言える。
QC 20100517
Hensley, Barry J. "Development of a software evolution process for military systems composed of integrated commercial off the shelf (COTS) components." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2000. http://handle.dtic.mil/100.2/ADA377711.
Повний текст джерелаThesis advisor(s): Osmundson, John. "March 2000." Includes bibliographical references (p. 153-155). Also available online.
Stückemann, Thomas. "Technikentwicklung als reflexiver Modernisierungsprozeß." Doctoral thesis, Technische Universität Dresden, 1999. https://tud.qucosa.de/id/qucosa%3A24770.
Повний текст джерелаThere are several means to analyse the intrinsic connection of technological development and social evolution in sociology today. The thesis examines technology and its development as part of social evolution from a system-theoretical point of view. Using this approach, terms like "technology" and "social evolution" are reformulated. "Technology" is a particular type of border of social systems, using the mode of causality in observing its environment; thus Technology is defined as the fixation of causal expectations. "Social evolution" is a social systems' structural change by the selection and reinforcement of variations, creating a singular history. In terms of sociology, any technological development is part of a wider developing social context. This is visualized by confronting the terms "progress" and "modernization"; both being concepts of sociology as well as of debates on technology and social development. By using technology, by giving way to innovation, and by limiting the use of technology, a given society tries to monitor and influence its own evolution. The thesis shows that these attempts become more complex, but not necessarily more effective. The fundamental properties of any evolution cannot be annulated --- the social evolution always remains unpredictable, even when evolutionary theories allow reflexive observations. In contrast to its predecessors the modern society constitutes a type of technology which is highly independent of any given social context. But this freedom is risky. Contextualizations and decision-makings imply a higher degree of reflexivity. In the case of technological development, both determinations and options increase at the same time. What is complex in technological development is its social, not its mere technical side. Any reflexive debate on technology has to reflect technology as a social issue.
Sones, Ronald T. "Development of a Theoretical Model Based Upon Factors Influencing a Firm's Suitability for Organizational Evolution." Also available to VCU users online at:, 2001. http://hdl.handle.net/10156/1397.
Повний текст джерелаRuiz, Carmona Luz Marcela. "TraceME: Traceability-based Method for Conceptual Model Evolution." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/64553.
Повний текст джерела[ES] La evolución de sistemas software es una de las actividades mas importantes que permiten minimizar el tiempo de puesta en producción de actualizaciones y nuevos desarrollos, reducir los costos que implica desarrollar una aplicación desde cero, y además asegura el acceso ininterrumpido de servicios. Existen variadas motivaciones para promover la investigación y desarrollo de soluciones para especificar y evolucionar sistemas de información mediante modelos conceptuales. Para contribuir al campo de la ingeniería de requisitos con métodos automáticos de producción de software, hemos diseñado el método TraceME para cubrir el espectro de actividades desde requisitos a código con un enfoque de evolución organizacional. De este modo, el espectro de actividades involucra diferentes perspectivas de análisis de sistemas de información que necesitan ser integradas. En este escenario tan complejo, la trazabilidad y los modelos conceptuales son conceptos clave. Es necesario disponer de mecanismos para trazar especificaciones de software desde requisitos a código con el fin de justificar procesos de evolución. Las versiones de los sistemas de información deben ser trazables con el fin de establecer la conexión entre especificaciones obsoletas y actuales. Adicionalmente, es necesario encontrar mecanismos para facilitar la especificación del cambio, su medición e interpretación. Para diseñar esta tesis hemos seguido el marco de Design Science de Roel Wieringa. Design Science nos ha proporcionado las claves para conducir esta investigación, ser rigurosos y poner en práctica reglas científicas. Además de que Design Science ha sido un factor clave para estructurar nuestra investigación, reconocemos que la aplicación de este marco nos ha ayudado a reportar claramente nuestros hallazgos. Hemos aplicado ingeniería de métodos para diseñar y construir TraceME. Gracias a esto, la naturaleza de TraceME es conformada mediante fragmentos de método. La arquitectura de TraceME abre una amplia ventana de oportunidades para su aplicación en situaciones de la vida real. Para facilitar la adopción industrial de TraceME, hemos desarrollado herramientas de software libre para dar soporte a los fragmentos de TraceME. Por ejemplo, un caso de estudio y una experiencia de action research han sido ejecutadas en dos organizaciones en España. La validación de TraceME ha sido llevada a cabo mediante demostraciones de laboratorio, experimentos controlados, un caso de estudio y una experiencia de action research en industria. Como resultado, TraceME ha sido mejorado considerablemente; además hemos descubierto investigaciones a realizar a corto, mediano y largo plazo con el fin de implementar TraceME en la industria. Las evidencias obtenidas como resultado de las validaciones demuestra la factibilidad de TraceME para ser aplicado en proyectos de evolución organizacional. El trabajo futuro nos motiva a afrontar los retos que conlleva el soporte de proyectos de evolución de sistemas de información.
[CAT] L'evolució dels sistemes programari és una de les activitats més importants que permeten minimitzar el temps de posada en producció d'actualitzacions i nous desenvolupaments, reduir els costos que involucra desenvolupar una aplicació des de cero, a més d' assegurar l'accés ininterromput de serveis. Existixen diverses motivacions per promoure la investigació i desenvolupament de solucions per a especificar i evolucionar sistemes de informació mitjançant models conceptuals. Per tal de contribuir al camp de l'enginyeria de requisits amb mètodes automàtics de producció de programari, hem dissenyat el mètode TraceME per cobrir l'espectre d'activitats des de requisits a codi en un enfocament d'evolució organitzacional. Així, l'espectre d'activitats involucra diferents perspectives d'anàlisi de sistemes d'informació que necessiten ser integrades. En aquest escenari tan complex, la traçabilitat i els models conceptuals són conceptes clau. És necessari disposar de mecanismes per traçar especificacions de programari des de requisits a codi amb la fi de justificar processos d'evolució. Les versions dels sistemes d'informació deuen ser traçables amb la fi d'establir la connexió entre especificacions obsoletes i actuals. Addicionalment, és necessari trobar mecanismes per facilitar l'especificació del canvi, la seua mesura i interpretació. Per tal de dissenyar aquesta tesi, hem seguit el marc de Design Science de Roel Wieringa. Design Science ens ha proporcionat les claus per conduir aquesta investigació, ser rigorosos i posar en pràctica regles científiques. A més a més, Design Science ha sigut un factor clau per estructurar la nostra investigació, reconeixem que l'aplicació de aquest marc ens a ajudat a reportar clarament els nostres resultats. Hem aplicat enginyeria de mètodes per dissenyar i construir TraceME. Gràcies a açò, la natura de TraceME es conforma mitjançant fragments de mètodes. L'arquitectura de TraceME obri una ampla finestra d'oportunitats per a la seua aplicació en situacions de la vida real. Per facilitar l'adopció industrial de TraceME, hem desenvolupat ferramentes de programari lliure per tal de donar suport als fragments de TraceME. Per exemple, un cas d'estudi i una experiència de action research han sigut executades en dos organitzacions a Espanya. La validació de TraceME ha sigut portada a cap mitjançant demostracions de laboratori, experiments controlats , un cas d'estudi i una experiència de action research en l'industria. Com a resultat, TraceME ha sigut millorada considerablement; a més a més, hem descobert investigacions a realitzar a curt, mig i llarg termini amb la fi d'implementar TraceME a l'industria. Les evidències obtingudes com a resultat de les validacions, demostren la factibilitat de TraceME per ser aplicat en projectes d'evolució organitzacional. El treball futur presenta nous reptes que ens motiven a afrontar el suport de projectes d'evolució de sistemes d'informació.
Ruiz Carmona, LM. (2016). TraceME: Traceability-based Method for Conceptual Model Evolution [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/64553
TESIS
Gaskin, James E. "Evolution and Variation of Digitally-enabled Design Routines: An extended event-sequencing approach." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1332172409.
Повний текст джерелаLindberg, Aron. "The Origin, Evolution, and Variation of Routine Structures in Open Source Software Development: Three Mixed Computational-Qualitative Studies." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1436527665.
Повний текст джерелаPérez-Posada, Alberto 1993. "Development of model systems to reconstruct the unicellular prehistory of animals : an emphasis on the cell cycle." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668275.
Повний текст джерелаThe origin of animal multicellularity has its roots in the process of cell division. Understanding the molecular basis of cell division in animals and their unicellular relatives has the potential to elucidate what changes in the control of cell division played a role, if any, in the transition to multicellularity. However, the experimental amenability of the closest relatives of animals is yet very limited. This thesis contributes to the development of Capsaspora owczarzaki, a close unicellular relative of animals, as a model organism, by developing genetic tools for DNA transfection and culture synchronization tools to study the cell cycle. Our characterization of the Capsaspora cell cycle revealed that many genes important in the cell cycle of animal cells are also transcriptionally regulated in Capsaspora, including the main orthologs of animal cyclins and CDKs present in Capsaspora. Likewise, the development of genetic tools opens the door to new functional studies in this species, which will allow to understand the role of many genes related to multicellularity under the context of a unicellular species.
Schramm, Lisa [Verfasser], Jürgen [Akademischer Betreuer] Adamy, and Bernhard [Akademischer Betreuer] Sendhoff. "Evolution of Cellular Systems - Optimization of Gene Regulatory Networks for the Development of Morphology and Control / Lisa Schramm. Betreuer: Jürgen Adamy ; Bernhard Sendhoff." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2012. http://d-nb.info/1106114868/34.
Повний текст джерелаFageehi, Yahya. "SIMULATION-BASED OPTIMIZATION FOR COMPLEX SYSTEMS WITH SUPPLY AND DEMAND UNCERTAINTY." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1531147903589262.
Повний текст джерелаCornudella, Gaya Miquel. "Autotelic Principle : the role of intrinsic motivation in the emergence and development of artificial language." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEE082/document.
Повний текст джерелаThis thesis studies the role of intrinsic motivation in the emergence and development of communicative systems in populations of artificial agents. To be more specific, our goal is to explore how populations of agents can use a particular motivation system called autotelic principle to regulate their language development and the resulting dynamics at the population level.To achieve this, we first propose a concrete implementation of the autotelic principle. The core of this system is based on the balance between challenges, tasks to be done to achieve a goal, and skills, the abilities the system can employ to accomplish the different tasks. The relation between the two elements is not steady but regularly becomes destabilised when new skills are learned, which allows the system to attempt challenges of increasing complexity. Then, we test the usefulness of the autotelic principle in a series of language evolution experiments. In the first set of experiments, a population of artificial agents should develop a language to refer to objects with discrete values. These experiments focus on how unambiguous communicative systems can emerge when the autotelic principle is employed to scaffold language development into stages of increasing difficulty. In the second set of experiments, agents should agree on a language to communicate with about colour samples. In this part, we explore how the motivation system can regulate the linguistic complexity of interactions for a continuous domain and examine the value of the autotelic principle as a mechanism to control several language strategies simultaneously. To summarise, we have shown through our work that the autotelic principle can be used as a general mechanism to regulate complexity in language emergence in an autonomous way for discrete and continuous domains
Whitehead, Joanne. "Genomic Imprinting in Development and Evolution." Doctoral thesis, Uppsala universitet, Zoologisk utvecklingsbiologi, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4491.
Повний текст джерелаPetropoulos, Ioannis. "Development of an antenna system for a relay-based wireless network : simulation and measurement of antenna systems for relay-based wireless network, covering the backhaul and access links and applying beam forming technology." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/5770.
Повний текст джерелаAmiri, Haleh. "Patterns and Processes of Molecular Evolution in Rickettsia." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5248-5/.
Повний текст джерелаRajakumar, Rajendhran. "The developmental basis of caste evolution in ants." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121172.
Повний текст джерелаLa plasticité phénotypique est l'habileté d'un génotype unique de produire des phénotypes adaptatifs alternes en réponse à des conditions environnementales facilitant leur survie. Dans certains cas, les conditions environnementales peuvent influencer le cours du développement d'un organisme, menant à l'induction d'une variation phénotypique nouvelle, qui est la matière brute pour la sélection en évolution. Bien que ce fait ait le potentiel d'unifier les champs distincts de l'écologie, du développement et de l'évolution, on commence seulement à étudier les mécanismes moléculaires fondamentaux qui traduisent l'environnement en diversité phénotypique. Les fourmis démontrent une grande plasticité phénotypique; durant le développement, un génotype unique peut produire une diversité de phénotypes adaptatifs qui démontrent des différences dramatiques de morphologie, de longévité, de reproduction et de comportement. Cette sensibilité environnementale est à la base de la diversité des systèmes complexes de castes chez les fourmis. Ici, j'ai utilisé le développement des genres hyperdiversifiés Pheidole et Camponotus comme modèles pour investiguer mon but principal, qui est de comprendre comment l'écologie (l'environnement) agit sur le développement, en générant de la variation morphologique qui peut par la suite mener à une évolution morphologique. Le premier objectif spécifique de ma thèse (Chapitre 2) est d'investiguer les bases hormonales et du développement des nouvelles sous-castes ouvrières chez les fourmis. Plus spécifiquement, le genre Pheidole est composé de plus de 1000 espèces, toutes démontrant un système de castes ouvrières complexe comprenant des ouvrières mineurs et des soldates. Chez un petit groupe de ces espèces, il existe une caste ouvrière additionnelle, la supersoldate. En utilisant des analyses phylogénétiques et de génétique du développement, j'ai déterminé que cette sous-caste a évolué en parallèle chez les différentes espèces. J'ai par la suite découvert, par des observations sur le terrain et des manipulations hormonales, qu'il existe un potentiel ancestral de développement dans ce groupe: toutes les espèces de Pheidole ont une capacité cachée de produire des supersoldates par induction environnementale, cette récurrence pouvant mener à leur évolution. Le second objectif spécifique de ma thèse (Chapitre 4) est d'investiguer les mécanismes épigénétiques qui traduisent les conditions environnementales en variation morphologique entre les castes. Plus spécifiquement, j'ai investigué le rôle de la méthylation de l'ADN dans l'élaboration d'une distribution de taille continue chez la caste ouvrière de Camponotus. J'ai découvert que la méthylation de l'ADN génère une distribution continue de taille chez la caste ouvrière et que l'une de ses cibles principales est le gène Egfr. D'ailleurs, le niveau de méthylation de Egfr est associé à une variation quantitative de la taille des ouvrières et une inhibition pharmacologique de la signalisation EGFR a démontré que cette voie de signalisation est capable de générer la distribution continue des tailles dans cette caste. La méthylation de l'ADN est un mécanisme épigénétique qui est connu pour causer une héritabilité transgénérationelle et donc, elle peut faciliter l'évolution d'une variation quantitative générée par l'environnement. Collectivement, les résultats de ma thèse montrent comment l'environnement agit sur le développement par l'intégration des hormones, des gènes et des mécanismes épigénétiques pour générer de la variation phénotypique sur laquelle la sélection naturelle peut agir par la suite. Peut-être que nous nous rapprochons d'un moment où la théorie de l'évolution peut proposer que l'environnement soit également important pour générer de la variation phénotypique qu'il peut l'être au cours du processus de sélection.
To, Cheryl. "Developmental changes in British children's reasoning about evolution." Thesis, University of Surrey, 2015. http://epubs.surrey.ac.uk/808456/.
Повний текст джерелаRuiz, Cody A. "Y-Chromosome Introgression: An Analysis of Spermatogenesis Genes Between Macaca mulatta and Macaca fascicularis." Kent State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=kent1501168493482051.
Повний текст джерелаKhan, Gul Muhammad. "Evolution of neuro-inspired Developmental Programs Capable of Learning." Thesis, University of York, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490693.
Повний текст джерелаHoang, Tuan-Hoa Information Technology & Electrical Engineering Australian Defence Force Academy UNSW. "Evolutionary Developmental Evaluation : the Interplay between Evolution and Development." Awarded by:University of New South Wales - Australian Defence Force Academy. Information Technology & Electrical Engineering, 2009. http://handle.unsw.edu.au/1959.4/44870.
Повний текст джерелаSanders, Heather Louise. "Developmental Changes in the Evolution of Fundamental Plant Organography." Ohio : Ohio University, 2007. http://www.ohiolink.edu/etd/view.cgi?ohiou1188579264.
Повний текст джерелаIoannidis, Stavros. "Developmental explanations of evolution : a challenge to neo-Darwinism?" Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601006.
Повний текст джерелаHarrison, Cecily Jill. "Developmental genetics and evolution of plant form in Streptocarpus." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/14005.
Повний текст джерелаCoulcher, J. F. "Evolution of the arthropod mandible : a molecular developmental perspective." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1335716/.
Повний текст джерелаNinova, Maria. "Developmental constraints on microRNA evolution and expression in insects." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/developmental-constraints-on-microrna-evolution-and-expression-in-insects(e6ad4075-c67f-4429-ab96-c12a2ed23d76).html.
Повний текст джерелаNemeth, Daniel C. "Evolution of the Coeloconic Sensilla in the Peripheral Olfactory System of Drosophila Mojavensis." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504798790782263.
Повний текст джерелаParmentier, Dominique. "Developmental flexibility and evolution of the worker caste in termites." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210790.
Повний текст джерела