Дисертації з теми "Evaluation biologique in vitro"
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Koumanov, Françoise. "Evaluation biologique d'analogues iodés du glucose : étude de leurs interactions avec le transporteur." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10115.
Bruyère, Pierre. "Evaluation thermodynamique et biologique d’un substituant synthétique aux produits d’origine animale dans les solutions de cryoconservation pour embryons de mammifères." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10145/document.
Several compounds in embryo cryopreservation solutions are a source of concern:products of animal origin because of the sanitary risks, and the permeating cryoprotectantsbecause of their potential mutagenic effect. Removing or substituting these compounds withchemically defined products might improve embryo cryopreservation technics.Conception and use of cryopreservation protocols are often empirical. This empiricismleads to many variations between the studies which make a comparison between results allthe more difficult. In our study, two complementary approaches were associated:• The first approach (physical) consisted of using the differential scanning calorimetry tostandardize the comparison between different slow-freezing solutions. So, thethermodynamic properties of solutions containing a potential substitute were characterizedand compared to those obtained with solutions containing reference products (fetal calfserum and bovine serum albumin) ;• The second approach (biological) consisted of using freezing of in vivo-produced rabbitembryos or freezing of in vitro-produced bovine embryos in order to evaluate survival
Bruyère, Pierre. "Evaluation thermodynamique et biologique d'un substituant synthétique aux produits d'origine animale dans les solutions de cryoconservation pour embryons de mammifères." Phd thesis, Université Claude Bernard - Lyon I, 2012. http://tel.archives-ouvertes.fr/tel-00936111.
Galgano, Camillo. "Evaluation des propriétés biologiques et de scellement de 4 matériaux endodontiques = [In vitro evaluation of the biological and sealing properties of four endodontic sealers] /." Genève : [s.n.], 2005. http://www.unige.ch/cyberdocuments/theses2005/GalganoC/these.pdf.
Le, Roux de Bretagne Isabelle. "Evaluation in vivo et in vitro d'un biomarqueur urinaire de la fonction du transporteur MRP2." Paris 6, 2011. http://www.theses.fr/2011PA066449.
Ducrot, Thierry. "Evaluation in vitro de l'activité biologique d'anticorps anti-Rh(D) utilisés dans la prévention de l'allo-immunisation foeto-maternelle : application à la sélection d'anticorps monoclonaux humains en substitution des immunoglobulines polyclonales spécifiques anti-D." Lille 1, 1996. http://www.theses.fr/1996LIL10208.
Ahlgren, Hanna [Verfasser], and Hilmar [Akademischer Betreuer] Bading. "NMDA receptor mediated contribution to neuronal cell death - an in vitro evaluation / Hanna Ahlgren ; Betreuer: Hilmar Bading." Heidelberg : Universitätsbibliothek Heidelberg, 2012. http://d-nb.info/1179784766/34.
Schoutteten, Laetitia. "Photophysique et photochimie du calcium green in vitro et ex vivo." Cachan, Ecole normale supérieure, 1997. http://www.theses.fr/1997DENS0022.
Griffoni, Chiara [Verfasser], Thomas [Gutachter] Dandekar, and Katharina [Gutachter] Maniura-Weber. "Towards advanced immunocompetent skin wound models for in vitro drug evaluation / Chiara Griffoni ; Gutachter: Thomas Dandekar, Katharina Maniura-Weber." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1200856333/34.
Edinger, Daniel [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "siRNA therapy for cancer : evaluation of oligomers for the in vitro and in vivo delivery / Daniel Edinger. Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1036836908/34.
Soulimani, Rachid Fleurentin Jacques. "RECHERCHE ET EVALUATION DE L'ACTIVITE BIOLOGIQUE DES SUBSTANCES VEGETALES SUR LE S.N.C. CHEZ LA SOURIS, IN VIVO ET VIS-A-VIS DES RECEPTEURS CHOLINERGIQUES, HISTAMINERGIQUES ET OPOIDES, IN VITRO, AU NIVEAU DU DUODENUM DE RAT ET DE L'ILEON DE COBAYE /." [S.l.] : [s.n.], 1992. ftp://ftp.scd.univ-metz.fr/pub/Theses/1992/Soulimani.Rachid.SMZ921.pdf.
Eichbaum, Kathrin Verfasser], Henner [Akademischer Betreuer] [Hollert, and Andreas [Akademischer Betreuer] Schäffer. "In vitro bioassay tools for the toxicological evaluation of dioxins and dioxin-like compounds in sediments and biota / Kathrin Eichbaum ; Henner Hollert, Andreas Schäffer." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1130326551/34.
Eichbaum, Kathrin [Verfasser], Henner [Akademischer Betreuer] Hollert, and Andreas [Akademischer Betreuer] Schäffer. "In vitro bioassay tools for the toxicological evaluation of dioxins and dioxin-like compounds in sediments and biota / Kathrin Eichbaum ; Henner Hollert, Andreas Schäffer." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://nbn-resolving.de/urn:nbn:de:hbz:82-rwth-2016-009703.
Najm, Nour Addeen [Verfasser], and Kurt [Akademischer Betreuer] Pfister. "In vitro culture studies of tick cell lines : "Endosymbionts in tick cell culture and evaluation of media conditions" / Nour Addeen Najm. Betreuer: Kurt Pfister." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1025047206/34.
M'Bengue, Marie-Stella. "Conception et évaluation d'une endoprothèse vasculaire par impression 3D pour le traitement des anévrismes complexes de l'aorte abdominale." Electronic Thesis or Diss., Université de Lille (2022-....), 2022. http://www.theses.fr/2022ULILS057.
Endovascular repair (EVAR) of an abdominal aortic aneurysm (AAA) involves the placement into the aneurysm of a stent graft (SG) by minimally invasive surgery. This procedure prevents rupture of the damaged tissue involved in an AAA, defined as a localized diameter dilation of the aorta. When the upstream portion of the aneurysm includes the peripheral renal and/or visceral arteries, the AAA is qualified as complex. In this case, the deployed SG is said “fenestrated”, in other words, perforated at the site of junctions to the peripheral arteries. Management of a complex AAA becomes more limiting as the fenestrated SG will be custom designed to match the anatomy of the aneurysm and the position of the peripheral arteries of the patient. This implies a manufacturing delay of several weeks, limits the management to stable aneurysms and excludes emergency situations. In this context, 3D printing (3DP) is of considerable interest for the fabrication of custom-made SGs in a very short time frame. Thus, the objective of this thesis work is to design a SG prototype by 3D printing of a medical grade thermoplastic polyurethane (TPU) (thermoplastic elastomer). The present work will validate the manufacturing process and the functionality of our 3DP-SG for its final application as an implantable medical device.First, the impact of the manufacturing process on the chemical, physical and physicochemical properties of TPU was studied at each step, from the pellets to the gamma-ray sterilization of a graft manufactured by fused filament deposition (FDM). In vitro preliminary evaluation of the cytotoxicity and hemocompatibility of TPU was carried out after the 3D printing and sterilization step. Aging of TPU under extreme oxidizing conditions was performed to predict the evolution of its properties in the long term. Subsequently, a design strategy for an endovascular implantable prototype was developed. The properties of said prototype were characterized by different techniques (SEC, TGA, DSC, FTIR, SEM, goniometry, uniaxial traction, ...). Its biological properties were evaluated in vitro by tests of cytocompatibility, hemocompatibility and contact with macrophages for 24 hours (acute inflammation). Moreover, the evolution of its physicochemical and mechanical properties was evaluated by in vitro aging studies.The characterization of the chemical, physical and physicochemical properties of TPU enabled the validation of a FDM printing manufacturing route and gamma ray sterilization of a crimpable SG prototype. The in vitro biological evaluation showed the non-cytotoxicity of the SG prototype by the extraction method. Moreover, the prototype was found to be weakly hemolytic and the platelets adhered on its surface were not activated. The low secretion of cytokines (IL-6 and TNF-α) upon contact with inactivated macrophages showed that the SG prototype does not exhibit a pro-inflammatory characteristic. Finally, aging studies showed an impact on the mechanical and surface properties of our SG prototype without compromising its functionality. Subsequently, the design strategy could evolve towards a functionalization of the SG prototype in order to prevent infections and thrombosis responsible for 2% and 6% of postoperative complications respectively
Mumbo, John Ochieng [Verfasser], Karl-Werner [Akademischer Betreuer] [Gutachter] Schramm, and Jean Charles [Gutachter] Munch. "In vitro synthesis and structural elucidation, occurrence and distribution, soil dissipation, aqueous photolysis and toxicity evaluation of bromo- and chlorocarbazoles / John Ochieng Mumbo ; Gutachter: Karl-Werner Schramm, Jean Charles Munch ; Betreuer: Karl-Werner Schramm." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1128819244/34.
LE, LEM GAEL. "Hispiduline et analogues : synthese et evaluation biologique." Paris 11, 1990. http://www.theses.fr/1990PA112289.
Celliere, Géraldine. "Multi-scale modeling of hepatic drug toxicity and its consequences on ammonia detoxification." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC100.
Ammonia removal is a key liver function. Recently, the consensus reaction scheme involved in hepatic ammonia detoxification has been shown to be insufficient to completely understand ammonia removal. In order to uncover the mechanisms at play, we have developed a series of competing explanations formulated as compartment ODE-based mathematical models. Using statistical procedures, the models have been evaluated and compared. The results suggest that the enzyme glutamate dehydrogenase is a crucial element of ammonia detoxification after acute liver damage. When modeling tissues, the choice of the geometry representation can influence quantitative model predictions. To improve the current 1D models, we have developed a multi-scale model of hepatic metabolism. The model represents each individual hepatocyte, the intracellular metabolism and the blood flow within the blood vessel network. The impact of the precise tissue micro-architecture representation on model predictions has been assessed and recommendations could be drawn concerning its importance. In a third part, the early phase of liver damage is investigated. We address the question whether it is possible to predict the extent of in vivo tissue damage following a paracetamol overdose, via a model and in vitro data. To do so, we have used a combination of pharmacokinetic and pharmacodynamic modeling including the following aspects: (i) the precise drug exposure profile, (ii) the metabolic activity differences between the in vitro and the in vivo situation, and (iii) spatial inhomogeneities within the liver. With these extensions, the prediction of in vivo paracetamol toxicity could be significantly improved
BORZAKIAN, STEEVES. "L'infection persistante du poliovirus in vitro : etude biologique et moleculaire." Paris 7, 1993. http://www.theses.fr/1993PA077329.
Gagnepain, Anne. "Fécondation in vitro : synthèse clinique, biologique, épidémiologique, législative et éthique ; méta-analyse des essais thérapeutiques." Montpellier 1, 1989. http://www.theses.fr/1989MON11258.
LIU, XUE-WU. "Etude du comportement physiologique et biologique d'algues marines en culture in vitro." Paris 6, 1991. http://www.theses.fr/1991PA066217.
Ouellet, Charles. "Évaluation biologique in vitro d'inhibiteurs de la stéroïde sulfatase ayant un effet SERM." Master's thesis, Université Laval, 2013. http://hdl.handle.net/20.500.11794/25169.
ROUX, FORESTIER MARIE ANGE. "Synthese et evaluation biologique de nouveaux analogues de nucleosides 23-modifies." Nice, 1993. http://www.theses.fr/1993NICE4690.
Anissian, H. Lucas. "In vitro evaluation of hip prostheses /." Stockholm, 2001. http://diss.kib.ki.se/2001/20010420anis/.
Corseaux, Delphine. "Evaluation de l'expression du facteur tissulaire en pathologie vasculaire expérimentale." Lille 1, 1998. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/1998/50376-1998-167.pdf.
Camps, Jean. "Mise au point d'un modele in vitro d'evaluation de la cytotoxicite des systemes adhesifs." Aix-Marseille 2, 1996. http://www.theses.fr/1996AIX21601.
Rouissi, Noureddine. "Étude de l'effet de divers inhibiteurs de protéases sur l'activité biologique de peptides in vitro." Mémoire, Université de Sherbrooke, 1989. http://hdl.handle.net/11143/12074.
Ayan, Diana. "Activité biologique in vitro et in vivo de dérivés stéroïdiens pour le traitement du cancer." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28565/28565.pdf.
Ayan, Diana Paula. "Activité biologique in vitro et in vivo de dérivés stéroïdiens pour le traitement du cancer." Master's thesis, Université Laval, 2011. http://hdl.handle.net/20.500.11794/24180.
Desailly-Chanson, Marie-Ange. "Evaluation d'une méthode rapide d'identification des anaérobies : an-ident." Bordeaux 2, 1989. http://www.theses.fr/1989BOR23063.
Yamamoto, Akiko. "Biocompatibility evaluation of metallic biomaterials in vitro." Kyoto University, 1998. http://hdl.handle.net/2433/182365.
MELZI, GLORIA. "IN VITRO GENOTOXIC EVALUATION OF ENVIRONMENTAL POLLUTANTS." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/945908.
Particulate matter (PM) is a complex and heterogeneous mixture of particles and has been recognized as a threat for human health. Hazardousness of PM is not only dependent on its dimensions, but also and in particular on its chemical composition. Initially, PM deposition in human alveoli induces oxidative stress and production of pro-inflammatory mediators. Later, the onset of DNA damages and their possible misrepair can lead to mutations. This project is part of the PRIN 2017 project RHAPS (Redox-activity and Health-effects of Atmospheric Primary and Secondary aerosol) and of the Horizon2020 project RAPTOR (Research of Aviation PM Technologies, mOdelling and Regulation). The aim of this research is to evaluate the effect of PM coming from different sources on a bronchial epithelial cell line (BEAS-2B) and lung epithelial cell line (Calu-3) considering oxidative stress, genotoxicity, and inflammation as main endpoints. RHAPS campaign allowed the collection and analysis of different dusts and filters collected in winter and in summer 2021. Winter PM was collected in Bologna (urban site) and San Pietro Capofiume (BO, rural site), while summer only in the site of Bologna. Dusts were diluted in water and used at different concentration to treat the cells, while PM1 was extracted in water with mechanic agitation and cells were treated with the extract diluted 1:10 in complete medium. RAPTOR allowed the collection of the emission of different types of aircraft engines, that were testes in air-liquid interface condition with an innovative method of exposure, the Cloud system, which allow the nebulization of the PM samples and the consequent deposition on the cells. All the analysis were performed at 24 hours, with the only exception of reactive oxygen species (ROS) detection that was analysed at 30 minutes and 1 hours. Cell viability was assessed with the MTT assay (RHAPS) and LDH assay (RAPTOR) and results were considered in order to avoid the use of cytotoxic concentration of further tests. ROS were detected with DCFH-DA assay. Moreover, comet assay modified with endonucleases ENDOIII and FPG allowed the detection of oxidative damage on the DNA bases. The alkaline version of the comet assay, the immunofluorescence for the phosphorylated histone H2AX (γ-H2AX), and the micronuclei test were used to highlight DNA damage at single and double strands as well as at chromosomal level. Inflammation was evaluated through the analysis of the release of interleukin-8 (IL-8) and CXCL-8 mRNA expression. Gene expression analysis was performed also for other genes involved in the DNA repair pathway (ATM and GADD45α), oxidative stress (HMOX and NQO1), and other mechanisms (ACE-2 and MUC5AC). Differences were detected in all the assays’ results among the samples analysed. Some samples showed increase level of ROS and oxidised DNA bases. Moreover, BEAS-2B cells resulted to be very sensitive to DNA damage as analysed by the presence of micronuclei and γ-H2AX. IL-8 secretion is stimulated in particular in some of the samples analysed, and its gene expression does not differ much from control level. Also, the other genes analysed showed different pattern of activation, depending on the samples with which they were treated. Interestingly, these results could be explained at the light of the chemical composition of the PM more than with the only analysis of PM mass concentration parameter; chemical composition seems to really drive the toxicological effect highlighted in this research.
Gautier, Benoit. "Evaluation biochimique et biologique d'antagonistes des récepteurs au VEGF à visée anti-angiogénique." Paris 5, 2009. http://www.theses.fr/2009PA05S004.
Tumoral angiogenesis is a novel therapeutic target in the treatment of solid tumor cancers. It is initiated, among others, by the binding of VEGF, a pro-angiogenic factor, on these receptors, the VEGFR. At the laboratory, we develop VEGFRs antagonists as original anti-angiogenic approach. This thesis has consisted in the biological assessment of peptides designed rationally and non-peptidic compounds identified by an in silico screening. Their biochemical activity was evaluated on non-radioactive displacement assays previously developed and then examined on endothelial cells. The results showed their antagonist effect with different specificities for VEGFR. Finally, a detailed study by NMR and by an Ala-scan showed residues of peptides involved in the interaction with VEGFR
Viry, Elodie. "Evaluation biologique de l'inhibition des phosphatases CDC25 dans des lignées d'adenocarcinomes mammaires humains." Thesis, Metz, 2010. http://www.theses.fr/2010METZ013S/document.
The CDC25 phosphatases are important regulators of eukaryotic cell cycle progression and play a crucial role in the activation of cyclin-dependent kinases (Cdk) by dephosphorylation. CDC25s are attractive targets in cancer therapy because their over-expression was reported in various types of human malignancies, including breast cancer, and this has been correlated with either poor prognosis or tumor aggressiveness.Our study aims to evaluate the CDC25s as interesting targets in breast cancer treatment. This study reports the inhibitory activity of two tetrasulfides : diallyl- (DAS4) and dipropyl- (DPS4) tetrasulfides naturally occurring in garlic and onion, towards the human cell division cycle (CDC) 25 phosphatases. Both compounds have emerged as interesting irreversible inhibitors of the CDC25 isoforms A and C in vitro.Then, we have investigated the anticancer properties of DAS4 et DPS4 on both sensitive (MCF-7 and MDA-MB-231) and resistant (Vcr-R) human breast carcinoma cell lines. Experiments performed on cultured cells have showed that growth of both sensitive and resistant cells was significantly decreased by these tetrasulfides and appeared to be associated with a G2/M cell cycle arrest. In addition, our results also suggested that DAS4 and DPS4 induce apoptotis in MCF-7 cells without affecting reactive oxygen species production. Analysis of mechanisms implicated in apoptosis induction in MCF-7 cells after treatment with DAS4 et DPS4 have suggested the involvement of the Bcl-2 family members. Taken together, these results suggest phosphatases CDC25A and C as possible targets of naturally occuring polysulfides contributing to their anticancer properties
Lagoutte, Delphine. "Evaluation de l'activité biologique de la canthin-6-one et de ses analogues." Paris 11, 2007. http://www.theses.fr/2007PA114826.
The canthin-6-one alkaloids are a subclass of β-carboline alkaloids with an additional D-ring. Canthin-6-one was first isolated in 1952 by Haynes et al. From Pentaceras australis; since then, more than forty members of this class of alkaloids have been reported from several plants primarily of the Rutaceae and Simaroubaceae families, but also from Malvaceae, Amaranthaceae, Caryophyllaceae, Zygophyllaceae, and recently from fungi (Boletus curtisii Berk. ). Several of them have been bioassayed in different areas, showing interesting pharmacological activities. In our studies, canthin-6-one and their derivatives, isolated from Zanthoxylum chiloperone var. Angustifolium and obtained by hemisynthesis and synthesis displayed antifungal and tuberculosis activities in vitro and in vivo. The mechanism of action of antifungal canthin-6-one was investigated in Saccharomyces cerevisiae. After a rapid uptake, a preferential accumulation of the drug within lipid droplets was observed. The antifungal action of canthin-6-one was found reversible. Canthin-6-one did not exhibit affinity for sterols and membrane ergosterol, but relative amount of unsaturated alkyl chain fatty acids was significantly enhanced suggesting a stimulation of desaturase enzyme systems
Ducousso, Mathieu. "Acoustique picoseconde dans une cellule biologique individuelle." Phd thesis, Université Sciences et Technologies - Bordeaux I, 2010. http://tel.archives-ouvertes.fr/tel-00537030.
MARIN, JEAN. "Mecanisme d'action et activite biologique du poly (a). Poly (u) : etudes in vitro et in vivo." Paris 11, 1992. http://www.theses.fr/1992PA112124.
Hunault, Julie. "Analogues 4-désoxy-galactosylcéramides à activité immunorégulatrice : synthèse et évaluation biologique in vitro et in vivo." Nantes, 2010. http://www.theses.fr/2010NANT2059.
This PhD work deals with the synthesis and biological evaluation of new ligands of iNKT cells, a particular subset of T lymphocytes wich exhibits NK cell features. Stimulation of those lymphocytes lead to rapid cytokine release which in turn activates two classes of lymphocyte T helpers called TH2 and TH1 responsible of allergic response and pro-inflammatory response, which is implicated in cancer, respectively. The major ligand of iNKT cells is a synthetic α-galactosylceramide, named α-GalCer (KRN 7000), resulting from pharmacomodulation research. It is currently in clinical evaluation for cancer therapy. According to a new synthetic strategy, we have developed new 4-deoxy-galactosylceramide analogs after we demonstrated that 4-deoxy-α-GalCer activates iNKT cells in a similar way to α-GalCer. The synthetic pathway allows us to developed, from a common intermediate, 4-deoxy-α-galactosylceramides analogs with modified sphingosine and acyl chains, a 3,4-deoxy-3- fluoro αGalCer analog and 4-deoxy-β-GalCer. We have also developed a synthesis of 3,4-deoxy-3,3-difluoro analog. Compound activity was evaluated in vitro with human iNKT cells and in vivo with mice. Results of those evaluation are very promising because most of these analogs are able to activate murine and human iNKT cells
BABA, KACEM. "99m technetium-glutathion (99m tc-gsh) caracterisation physico-chimique et biologique in vitro et in vivo." Paris 13, 2000. http://www.theses.fr/2000PA132011.
Boyer, Antoine. "Synthèse, caractérisation et évaluation biologique d'apatites phosphocalciques carbo silicatées." Phd thesis, Ecole Nationale Supérieure des Mines de Saint-Etienne, 2014. http://tel.archives-ouvertes.fr/tel-01068540.
Bruyère, Arnaud. "Etudes in vitro du métabolisme et du transport intestinal humain avec modélisation in vitro/in vivo par approche physiologique." Paris 5, 2010. http://www.theses.fr/2010PA05P608.
LAVRADOR, KARINE. "Synthese et evaluation biologique de nouveaux inhibiteurs de la s-adenosyl-l-methionine synthetase." Reims, 1996. http://www.theses.fr/1996REIMS009.
Nathanaelsson, Lena, and Linda Sandström. "Statistical evaluation of in vitro gas production kinetics." Thesis, Umeå universitet, Institutionen för matematik och matematisk statistik, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51348.
Farrell, Laura-Lee Amelia Catherine. "Prosthetic Vein Valve: Delivery and In Vitro Evaluation." Thesis, Available online, Georgia Institute of Technology, 2007, 2007. http://etd.gatech.edu/theses/available/etd-04042007-180135/.
Falomo, Olajumoke. "In vitro Evaluation of Resistant Starch Using Corn." OpenSIUC, 2016. https://opensiuc.lib.siu.edu/theses/1939.
Li, Li. "Vieillissement de la peau : approches biométrologique (topographie et microcirculation) et biologique (biologie du fibroblaste dermique in vitro)." Besançon, 2005. http://www.theses.fr/2005BESA3009.
Skin ageing is mainly characterized by the deterioration of the cutaneous texture and the formation of wrinkles. Ln this work, the evolution of the microrelief and the wrinkles have been studied using methods of descriptive, photographic scales and projection of fringes. The results show that the earliest and most marked wrinkles are those of the crow's feet as a result of the local muscles repeated movements. They are more marked in the Caucasian population compared with the Chinese population, and in the population of the South compared with the North (effect of UV). Besides, the dermal structure, the proliferation and the metabolism of the fibroblasts of the wrinkle (elastin, collagens I/III, capacity of retraction) were studied by immuno-histological colorings, the technique of monolayer and tri-dimensional culture modal. These investigations in the mechanisms of cutaneous ageing help to design better strategies in dermato-cosmetology treatments
Tey-Rulh, Patricia. "Métabolites toxiques sécrétés in vitro par Eutypa lata, parasite de la vigne isolement, identification et activité biologique /." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37618835c.
Cunat, Lisiane Burnel Daniel. "BIODISPONIBILITE DE L'ALUMINIUM DANS L'INTESTIN. ETUDES IN VITRO ET IN VIVO CHEZ LE RAT /." [S.l.] : [s.n.], 1999. ftp://ftp.scd.univ-metz.fr/pub/Theses/1999/Cunat.Lisiane.SMZ9931.pdf.
Bonnin, Alain. "Cryptosporidium parvum : étude biologique en culture in vitro : caractérisation et immunolocalisation de déterminants antigéniques à l'aide d'anticorps monoclonaux." Dijon, 1991. http://www.theses.fr/1991DIJOMU02.
Le, Flem Guillaume. "Synthèse d'analogues séquentiels de l'insuline : étude de leur relation strucuture-fonction et de leur activité biologique in vitro." Amiens, 2002. http://www.theses.fr/2002AMIED002.