Дисертації з теми "Eukaryotic mitochondria"
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Brindefalk, Björn. "Mitochondrial and Eukaryotic Origins : A Phylogenetic Perspective." Doctoral thesis, Uppsala universitet, Molekylär evolution, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100147.
Повний текст джерелаMILANESI, RICCARDO. "Metabolism and signaling crosstalk regulates nutrients perception and mitochondrial respiration in eukaryotic model systems." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/375389.
Повний текст джерелаReceptors and signal transduction pathways have been studied for decades depicting the mechanism responsible for the perception of nutrients and growth factors. Nevertheless, an increasing amount of evidence suggest that signal transduction is inherently connected also to intracellular metabolism through protein-metabolite interactions (PMIs) between metabolites and proteins of the signal transduction pathways. All the eukaryotes present conserved pathway for the sensing of carbon and nitrogen sources responsible for the coordination of cell growth with its nutritional state. Metabolites belonging to the upper glycolysis strongly influence PKA and Snf1/AMPK/SnRK1 activation state in yeast and mammalian and plants cells. In the meanwhile, components of the TORC1 pathway result to be the center of interaction for the sensing of amino acids availability. Interestingly, the crosstalk between Snf1/AMPK and Ras/PKA pathways, as well as glucose regulation of Snf1/AMPK activity in yeast is not completely understood yet. In the present thesis, we demonstrate that Snf1/AMPK and Ras/PKA pathway are independently controlled by glucose metabolism through the synthesis of glucose 6-phosphate and fructose 1,6-bisphosphate, respectively. Hence, we proved that Snf1/AMPK activation state is controlled by glucose transport rate and not by glucose availability, providing evidence suggesting that glucose 6-phosphate may directly interact with Snf1 complex and enhance the exposure to phosphatases of the phosphorylated regulatory threonine (T210). Nutrients also have a strong impact on cellular aging and eukaryotic microorganisms or simple pluricellular organisms can be useful model organisms for the study of the aging process. In a collaborative study, we evaluated the properties of the bean Vigna unguicolata as functional food ameliorating aging and neurodegeneration. Bean extracts extend the life span of Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans and mammalian cells. Furthermore, bean extracts also showed neuroprotective properties, reducing the in vitro aggregation of α-synuclein and decreasing the age-related degeneration of cephalic dopaminergic neurons in Caenorhabditis elegans. In the second part of the thesis, we investigate new putative approaches for the treatment of hepatocellular carcinoma (HCC). A preliminary study showed that the coupling of SNF1 deletion with methionine supplementation rewires yeast metabolism and reduces its proliferation. Being methionine and S-adenosylmethionine metabolism mainly active in the liver, we investigated whether AMKP inhibition coupled with a high methionine dosage can ameliorate the phenotype of hepatocellular carcinoma cell lines. These conditions increased the activity of the TCA cycle and the amount of ATP derived from respiration. Furthermore, this reduction of the Warburg phenotype was associated with a reduction of the aggressiveness of the hepatocellular carcinoma cell lines HepG2 and Huh7. S-adenosylmethionine is also an important fine chemical used in the treatment of alcoholism and depression or for the synthesis of melatonin, antibiotics and flavonoids. In the last part of this thesis, I present the advancement of the engineering of the environmental bacteria Pseudomonas putida for the overproduction of SAM. To pursue this goal, we designed a feedback-free inducible pathway to duplicate SAM production pathways in P. putida and coupling it with the TCA cycle. The building of this engineered strain forced us to deal with the robustness of P. putida central carbon metabolism and to investigate possible anaplerotic reaction replenishing the TCA cycle. This allowed us to gain useful details on the regulation of the TCA metabolism in P. putida and highlighted that information acquire in enterobacteria Escherichia coli are not always translatable to other type of bacteria.
Garg, Sriram [Verfasser], and Peter [Gutachter] Jahns. "Mitochondria and major transitions at eukaryote origin / Sriram Garg ; Gutachter: Peter Jahns." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1153604876/34.
Повний текст джерелаHe, Ding. "Inferring Ancestry : Mitochondrial Origins and Other Deep Branches in the Eukaryote Tree of Life." Doctoral thesis, Uppsala universitet, Systematisk biologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-231670.
Повний текст джерелаGawryluk, Ryan. "Comparative Proteomics: Studies on the Composition and Evolution of the Mitochondrial Proteome in Eukaryotic Microbes (Protists)." 2011. http://hdl.handle.net/10222/14078.
Повний текст джерелаNamala, Gayatri Devi M. "Uncovering the role of NFS1 in Fe-S cluster biogenesis and in the development of Infantile mitochondrial complex II/III deficiency (IMC23D) disease progression and 2. Screening single domain antibody (VHH) against a membrane transporter." Thesis, 2018. https://etd.iisc.ac.in/handle/2005/4504.
Повний текст джерелаPetrů, Markéta. "Bakteriální proteiny v biogenezi mitochondrií jednobuněčných eukaryot." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-409225.
Повний текст джерелаTing, Yu-Chien, and 丁于倩. "Quantum Biology Analysis of the Oxygen Reduction Reaction Mechanism at Mitochondria: the Power Generator of Eukaryotic Organisms." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/8skbut.
Повний текст джерела國立清華大學
動力機械工程學系
101
Cytochrome c oxidase is a mitochondrial membrane bounded enzyme which is the fourth complex of the respiratory electron transport chain. Cytochrome c oxidase catalyzes the respiratory reduction reaction of O2 to water. Reduction of O2 takes places at the metallic center of the cytochrome c oxidase. This thesis intensively studies the oxygen reduction reaction using the first principles calculations based on the time-independent density functional theory (TI-DFT) with the B3LYP /6-31G (d, p) method in the Gaussian09 program. It is generally agreed that DFT methods give accurate results for the geometries and vibrational frequencies of transition metals. In this study, the functional model of the metallic active site in the respiratory enzyme cytochrome c oxidase is simulated and the output data are used to analyze the bond length, band gaps, molecular orbitals, IR spectra, the structure energy and the reaction energy of the oxygen reduction reaction (ORR). The metallic active center was calculated with three different multiplicities, which are singlet, triplet, and quintet. According to the results of geometric energy of different multiplicities, we can sum up the reaction center of cytochrome c oxidase to be quintet. Finally, the total energy of the reaction product is calculated and the reaction energy of the ORR is discussed in this thesis.
Samaddar, Madhuja. "Understanding in vivo Significance of Allosteric Regulation in mtHsp70s : Revealing its Implications in Parkinson's Disease Progression." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3034.
Повний текст джерелаSamaddar, Madhuja. "Understanding in vivo Significance of Allosteric Regulation in mtHsp70s : Revealing its Implications in Parkinson's Disease Progression." Thesis, 2015. http://hdl.handle.net/2005/3034.
Повний текст джерелаStilger, Krista L. "Identification of TgElp3 as an essential, tail-anchored mitochondrial lysine acetyltransferase in the protozoan pathogen toxoplasma gondii." Thesis, 2014. http://hdl.handle.net/1805/4660.
Повний текст джерелаToxoplasma gondii, a single-celled eukaryotic pathogen, has infected one-third of the world’s population and is the causative agent of toxoplasmosis. The disease primarily affects immunocompromised individuals such as AIDS, cancer, and transplant patients. The parasites can infect any nucleated cell in warm-blooded vertebrates, but because they preferentially target CNS, heart, and ocular tissue, manifestations of infection often include encephalitis, myocarditis, and a host of neurological and ocular disorders. Toxoplasma can also be transmitted congenitally by a mother who becomes infected for the first time during pregnancy, which may result in spontaneous abortion or birth defects in the child. Unfortunately, the therapy currently available for treating toxoplasmosis exhibits serious side effects and can cause severe allergic reactions. Therefore, there is a desperate need to identify novel drug targets for developing more effective, less toxic treatments. The regulation of proteins via lysine acetylation, a reversible post-translational modification, has previously been validated as a promising avenue for drug development. Lysine acetyltransferases (KATs) are responsible for the acetylation of hundreds of proteins throughout prokaryotic and eukaryotic cells. In Toxoplasma, we identified a KAT that exhibits homology to Elongator protein 3 (TgElp3), the catalytic component of a transcriptional elongation complex. TgElp3 contains the highly conserved radical S-adenosylmethionine and KAT domains but also possesses a unique C-terminal transmembrane domain (TMD). Interestingly, we found that the TMD anchors TgElp3 in the outer mitochondrial membrane (OMM) such that the catalytic domains are oriented towards the cytosol. Our results uncovered the first tail-anchored mitochondrial KAT reported for any species to date. We also discovered a shortened form of Elp3 present in mouse mitochondria, suggesting that Elp3 functions beyond transcriptional elongation across eukaryotes. Furthermore, we established that TgElp3 is essential for parasite viability and that its OMM localization is important for its function, highlighting its value as a potential target for future drug development.
Laloraya, Shikha. "A eukaryotic GrpE related protein, Mgelp, modulates the function of mitochondrial Hsp70 in translocation of mitochondrial preproteins." 1996. http://catalog.hathitrust.org/api/volumes/oclc/34990513.html.
Повний текст джерелаPike, Schuyler Todd 1966. "Characterization of mitochondrial C₁-tetrahydrofolate synthase transcript and protein expression in adult and embryonic mammalian tissues and the role of the mitochondrial one-carbon pathway in the cytoplasmic methyl cycle." 2008. http://hdl.handle.net/2152/18094.
Повний текст джерелаtext
Schreiner, Patrick [Verfasser]. "Structural investigation of two supramolecular complexes of the eukaryotic cell : the proteasome and the mitochondrial TOM complex / Patrick Schreiner." 2008. http://d-nb.info/991585429/34.
Повний текст джерелаGilady, Susanna Yael. "Oxygen is required to retain Ero1[alpha] on the MAM." 2009. http://hdl.handle.net/10048/696.
Повний текст джерелаA thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science, Department of Cell Biology. Title from pdf file main screen (viewed on October 24, 2009). Includes bibliographical references.