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Статті в журналах з теми "Eukaryotic initiation factor eIF4GI"
Gradi, Alessandra, Hiroaki Imataka, Yuri V. Svitkin, Eran Rom, Brian Raught, Shigenobu Morino, and Nahum Sonenberg. "A Novel Functional Human Eukaryotic Translation Initiation Factor 4G." Molecular and Cellular Biology 18, no. 1 (January 1, 1998): 334–42. http://dx.doi.org/10.1128/mcb.18.1.334.
Повний текст джерелаRobert, Francis, Regina Cencic, Renying Cai, T. Martin Schmeing, and Jerry Pelletier. "RNA-tethering assay and eIF4G:eIF4A obligate dimer design uncovers multiple eIF4F functional complexes." Nucleic Acids Research 48, no. 15 (August 4, 2020): 8562–75. http://dx.doi.org/10.1093/nar/gkaa646.
Повний текст джерелаColdwell, Mark J., Ulrike Sack, Joanne L. Cowan, Rachel M. Barrett, Markete Vlasak, Keiley Sivakumaran, and Simon J. Morley. "Multiple isoforms of the translation initiation factor eIF4GII are generated via use of alternative promoters, splice sites and a non-canonical initiation codon." Biochemical Journal 448, no. 1 (October 18, 2012): 1–11. http://dx.doi.org/10.1042/bj20111765.
Повний текст джерелаYanagiya, Akiko, Yuri V. Svitkin, Shoichiro Shibata, Satoshi Mikami, Hiroaki Imataka, and Nahum Sonenberg. "Requirement of RNA Binding of Mammalian Eukaryotic Translation Initiation Factor 4GI (eIF4GI) for Efficient Interaction of eIF4E with the mRNA Cap." Molecular and Cellular Biology 29, no. 6 (December 29, 2008): 1661–69. http://dx.doi.org/10.1128/mcb.01187-08.
Повний текст джерелаCaron, Sandrine, Martine Charon, Elisabeth Cramer, Nahum Sonenberg, and Isabelle Dusanter-Fourt. "Selective Modification of Eukaryotic Initiation Factor 4F (eIF4F) at the Onset of Cell Differentiation: Recruitment of eIF4GII and Long-Lasting Phosphorylation of eIF4E." Molecular and Cellular Biology 24, no. 11 (June 1, 2004): 4920–28. http://dx.doi.org/10.1128/mcb.24.11.4920-4928.2004.
Повний текст джерелаÁlvarez, Enrique, Luis Menéndez-Arias, and Luis Carrasco. "The Eukaryotic Translation Initiation Factor 4GI Is Cleaved by Different Retroviral Proteases." Journal of Virology 77, no. 23 (December 1, 2003): 12392–400. http://dx.doi.org/10.1128/jvi.77.23.12392-12400.2003.
Повний текст джерелаColdwell, Mark J., and Simon J. Morley. "Specific Isoforms of Translation Initiation Factor 4GI Show Differences in Translational Activity." Molecular and Cellular Biology 26, no. 22 (September 18, 2006): 8448–60. http://dx.doi.org/10.1128/mcb.01248-06.
Повний текст джерелаPatel, Krishnaben, Grishma K. Shah, Sai Shilpa Kommaraju, and Woon-Kai Low. "Investigation of the conserved glutamate immediately following the DEAD box in eukaryotic translation initiation factor 4AI." Biochemistry and Cell Biology 92, no. 1 (February 2014): 33–42. http://dx.doi.org/10.1139/bcb-2013-0076.
Повний текст джерелаNeff, Carrie L., and Alan B. Sachs. "Eukaryotic Translation Initiation Factors 4G and 4A from Saccharomyces cerevisiae Interact Physically and Functionally." Molecular and Cellular Biology 19, no. 8 (August 1, 1999): 5557–64. http://dx.doi.org/10.1128/mcb.19.8.5557.
Повний текст джерелаLi, Qiyu, Hiroaki Imataka, Shigenobu Morino, George W. Rogers, Nancy J. Richter-Cook, William C. Merrick, and Nahum Sonenberg. "Eukaryotic Translation Initiation Factor 4AIII (eIF4AIII) Is Functionally Distinct from eIF4AI and eIF4AII." Molecular and Cellular Biology 19, no. 11 (November 1, 1999): 7336–46. http://dx.doi.org/10.1128/mcb.19.11.7336.
Повний текст джерелаДисертації з теми "Eukaryotic initiation factor eIF4GI"
Li, Qiyu. "Eukaryotic translation initiation factor eIF4AIII is functionally distinct from eIF4AI and eIF4AII." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0035/MQ64391.pdf.
Повний текст джерелаLi, Qiyu 1972. "Eukaryotic translation initiation factor eIF4AIII is functionally distinct from eIF4AI AND eIF4AII." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30687.
Повний текст джерелаShahbazian, David. "Eukaryotic initiation factor 4B (eIF4B) : regulation by signaling pathways and its role in translation." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115902.
Повний текст джерелаSignal transduction regulates multiple cellular processes including mitogenesis, differentiation, apoptosis, chemotaxis etc. Signaling pathways also regulate ribosomal biogenesis to coordinate mitogenic cues, nutrient and energy availability with the translational capacity of the cells. Mounting evidence links PI3K-Akt-mTOR and Ras-MAPK cascades to the translational control. In this thesis, I show that PI3K/mTOR and MAP kinase cascades converge to phosphorylate eIF4B on Ser422. This phosphorylation results in an increased interaction with eIF3, an essential factor bridging between eIF4F and the small ribosomal subunit. Physiological significance of eIF4B phosphorylation on Ser422 has been demonstrated by the stimulatory effect of eIF4B Ser422Asp phosphomimetic mutant on cap-dependent translation. Taken together, this represents a new paradigm of translational control mechanism regulated by signaling crosstalk. The function of eIF4B in vitro is well characterized but its in vivoeffects are disputed in literature. To address this I established HeLa cell line stably expressing shRNA targeting eIF4B. eIF4B silencing inhibits proliferation rates and anchorage-independent growth. Expression of luciferase reporter gene containing 5' terminal oligopyrimidine tract (TOP) is selectively repressed in eIF4B-silenced cells and can be rescued by exogenous eIF4B regardless of Ser422 phosphorylation status. Moreover, the de novo synthesis rates of endogenous ribosomal proteins in serum starved cultures recapitulate the luciferase reporter assay data. Utilizing polysomal analysis, I was able to show more significant inhibition of translation initiation in serum starved eIF4B-silenced cells. Our attempt to discover novel eIF4B-interacting proteins by Mass Spectrometry approach led to the identification of nucleolar RNA helicase DDX21. Confocal microscopy has shown partial co-localization of tagged eIF4B and DDX21 in nucleolar periphery. Pulse chase experiments metabolically labeling rRNA show an attenuated 28S rRNA production and concomitant accumulation of 36S intermediates in eIF4B-silenced cells. Since ribosomal biogenesis is highly coordinated process and requires strict stoichiometry maintenance of ribosomal components the observed inhibition of rRNA processing could be consequential to the decreased ribosomal protein expression. However, given the fact that eIF4B is associated with the nucleolar pre-ribosomal particle complexes its direct effect on rRNA processing cannot be ruled out. Regulation of ribosomal biogenesis by translation initiation factor may represent an important control mechanism allowing cells to co-ordinate these two processes.
Combe, Jonathan P. "The isolation and functional analysis of the eukaryotic translation initiation factor eIF4E from tobacco." Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/29777.
Повний текст джерелаRuud, Kelley Astrid. "Identification and characterization of a novel cap-binding protein from Arabidopsis thaliana and of the wheat eukaryotic initiation factor eIF4G /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.
Повний текст джерелаJones, Grant D. "Discovery, Phylogenetic Analysis, and Functional Characterization of a Unique Family of Eukaryotic Translation Initiation Factor 4E, eIF4E, From Amphidinium carterae, a Marine Dinoflagellate." Thesis, University of Maryland, Baltimore, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10118645.
Повний текст джерелаThis study investigates the eIF4E family members in Dinoflagellates. Dinoflagellates are eukaryotic algae with large genomes and a minimal role for transcriptional regulation. All mRNA in dinoflagellates is trans -spliced with a 22-nucleotide 5'-spliced-leader sequence bearing a multi-methylated cap. Like other eukaryotes, dinoflagellates encode multiple eIF4E family members that are anticipated to fulfill a range of functions. Three distinct and novel clades of eIF4E have been recognized in dinoflagellates that are separate from the three metazoan classes of eIF4E. The dinoflagellate Amphidinium carterae encodes eight eIF4E family members while Karlodinium veneficum encodes fifteen eIF4E family members. I assayed six of these family members from A. carterae for expression levels, m7GTP binding, yeast knockout complementation and affinity for three mRNA cap analogs using surface plasmon resonance (SPR). Transcripts of each are expressed through a diel cycle, but only eIF4E-1 family members and eIF4E-2a are expressed at the level of protein. Recombinant eIF4E-1 family members and eIF4E-3a, but not eIF4E-2a, are able to bind to m 7GTP-agarose beads. Of the clade 1 eIF4Es, only eIF4E-1a and -1d1 complement a S. cerevisiae strain conditionally deficient in functional eIF4E, consistent with their function as translation initiation factors. However, only eIF4E-1a can be recovered from A. carterae extracts by m7GTP affinity binding. Using SPR analysis, the affinity of A. carterae eIF4E-1a for m7GTP is lower than that of murine eIF4E-1A. By the same analysis, A. carterae eIF4E-1a has a higher affinity for m7GpppG than m7GTP. In addition, K. veneficum eIF4E-1a1 displays many of the same characteristics as A. carterae eIF4E-1a. Four eIF4E-1 and one eIF4E-2 family members from K. veneficum were characterized for m7GTP binding capacity, only the eIF4E-1 family members can be pulled down with m7GTP. Three eIF4E family members were tested for their ability to interact with a putative eIF4E-interacting protein, although none interacted. Overall, the eIF4E-1a sub-clade emerges with characteristics consistent with the role of a prototypical translation initiation factor. These initial analyses will allow for a better understanding of specific translational control of gene expression through mRNA recruitment in the unique dinoflagellate lineage.
Metz, Anneke Maria. "Function of the wheat eukaryotic initiation factors eIF(ISO)4G and eIF4B in translation /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.
Повний текст джерелаGreen, Simon Richard. "Molecular analysis of eukaryotic initiation factor 2#alpha#." Thesis, University of Kent, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330170.
Повний текст джерелаBottari, Nicolas. "Putative role of eukaryotic initiation factor 4AIII in the nucleus." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78325.
Повний текст джерелаFennell, Clare. "Characterisation of the eukaryotic initiation factor 2alpha kinases of Plasmodium falciparum." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/527/.
Повний текст джерелаКниги з теми "Eukaryotic initiation factor eIF4GI"
Vasilescu, S. Structure function and intracellular localisation of the eukaryotic initiation factor eIF4E in theyeast Saccharomyces cerevisiae. Manchester: UMIST, 1996.
Знайти повний текст джерелаGordon, Edys D. Studies on the hypusine-containing protein, eukaryotic initiation factor, EIF-4D. 1987.
Знайти повний текст джерела(Editor), A. Y. Liu, and K. Y. Chen (Editor), eds. Hypusyne Formation on Eukaryotic Initiation Factor 5A: Biochemistry & Function (Biological Signals Ser. Series, 3). S Karger Pub, 1997.
Знайти повний текст джерелаЧастини книг з теми "Eukaryotic initiation factor eIF4GI"
You, Tao, George M. Coghill, and Alistair J. P. Brown. "Eukaryotic Translation Initiation Factor Interactions." In Encyclopedia of Systems Biology, 675–78. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_831.
Повний текст джерелаGupta, Naba K., Mir F. Ahmad, Debopam Chakrabarti, and Nargis Nasrin. "Roles of Eukaryotic Initiation Factor 2 and Eukaryotic Initiation Factor 2 Ancillary Protein Factors in Eukaryotic Protein Synthesis Initiation." In Translational Regulation of Gene Expression, 287–334. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5365-2_14.
Повний текст джерелаProud, Christopher G. "Regulation of Eukaryotic Initiation Factor eIF2B." In Signaling Pathways for Translation, 95–114. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-56688-2_4.
Повний текст джерелаWestermann, P., R. Benndorf, G. Lutsch, H. Bielka, and O. Nygård. "Arrangement of Eukaryotic Initiation Factor 3 and Messenger RNA within Preinitiation Complexes." In Springer Series in Molecular Biology, 642–57. New York, NY: Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4612-4884-2_37.
Повний текст джерелаProstko, Christopher R., Margaret A. Brostrom, and Charles O. Brostrom. "Reversible phosphorylation of eukaryotic initiation factor 2α in response to endoplasmic reticular signaling." In Reversible Protein Phosphorylation in Cell Regulation, 255–65. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2600-1_24.
Повний текст джерелаRiera, Marta, Nerea Roher, Francesc Miró, Carles Gil, Ramon Trujillo, José Aguilera, Maria Plana, and Emilio Itarte. "Association of protein kinase CK2 with eukaryotic translation initiation factor eIF-2 and with grp94/endoplasmin." In A Molecular and Cellular View of Protein Kinase CK2, 97–104. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4419-8624-5_12.
Повний текст джерелаKaempfer, Raymond. "The Interaction between Viral Messenger RNA and Eukaryotic Initiation Factor 2, a Protein Involved in Translational Control." In Viral Messenger RNA, 21–48. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2585-7_2.
Повний текст джерелаJennings, Martin D., and Graham D. Pavitt. "Quantifying the Binding of Fluorescently Labeled Guanine Nucleotides and Initiator tRNA to Eukaryotic Translation Initiation Factor 2." In Methods in Molecular Biology, 89–99. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1975-9_6.
Повний текст джерелаCaraglia, Michele, Pierosandro Tagliaferri, Alfredo Budillon, and Alberto Abbruzzese. "Post-Translational Modifications of Eukaryotic Initiation Factor-5A (eIF-5a) as a New Target for Anti-Cancer Therapy." In Advances in Nutrition and Cancer 2, 187–98. Boston, MA: Springer US, 1999. http://dx.doi.org/10.1007/978-1-4757-3230-6_16.
Повний текст джерелаGreen, Simon R., and Michael B. Mathews. "The phosphorylation of eukaryotic initiation factor 2 and its role in the regulation of translation during viral infection." In Post-transcriptional Control of Gene Expression, 177–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-60929-9_15.
Повний текст джерелаТези доповідей конференцій з теми "Eukaryotic initiation factor eIF4GI"
Li, Yikun, Junghui Koo, Songqing Fan, Ping Yue, Taofeek K. Owonikoko, Suresh S. Ramalingam, Fadlo R. Khuri, and Shi-Yon Sun. "Abstract 1953: Elevated eukaryotic translation initiation factor 4E (eIF4E) is involved in erlotinib resistance." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1953.
Повний текст джерелаJaiswal, Praveen, Sweaty Koul, Nallasivam Palanisamy, and Hari K. Koul. "Abstract 4385: Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1): A target for cancer therapeutic intervention." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4385.
Повний текст джерелаJaiswal, Praveen, Sweaty Koul, Nallasivam Palanisamy, and Hari K. Koul. "Abstract 4385: Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1): A target for cancer therapeutic intervention." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-4385.
Повний текст джерелаZuberek, Joanna, Janusz Stępiński, Anna Niedzwiecka, Ryszard Stolarski, Harri Salo, Harri Lönnberg, and Edward Darżynkiewicz. "Synthesis of tetraribonucleotide cap analogue m7GpppAm2'pUm2'pAm2' and its interaction with eukaryotic initiation factor eIF4E." In XIIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2002. http://dx.doi.org/10.1135/css200205399.
Повний текст джерелаJaiswal, Praveen K., Sweaty Koul, Prakash Srinivasan Timiri Shanmugam, and Hari K. Koul. "Abstract 4436: Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) is upregulated modulates prostate cancer growth and proliferation." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4436.
Повний текст джерелаde la Parra, Columba, Elisa Otero-Franqui, and Suranganie Dharmawardhane. "Abstract 1988: Increased expression of eukaryotic protein synthesis initiation factor eIF4G by the daidzein metabolite equol may contribute to breast cancer malignancy." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1988.
Повний текст джерелаReich, Siegfried H., Peggy A. Thompson, Justin T. Ernst, Boreth Eam, Nathan P. Young, Sarah Fish, Joan Chen, et al. "Abstract DDT02-05: eFT226: A selective and highly potent inhibitor of eukaryotic initiation factor 4A (eIF4A), a novel approach for the treatment of cancer." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-ddt02-05.
Повний текст джерелаChakravarti, Nitin, Carla L. Warneke, Marcella M. Johnson, Michael A. Davies, and Victor G. Prieto. "Abstract 1486: Increased expression and phosphorylation of eukaryotic initiation factor 4E (eIF4E) and 4E-binding protein (4E-BP1) correlates with disease progression and high risk clinical/pathological features in melanoma." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1486.
Повний текст джерелаRamamurthy, Vidya priyadarsini, Senthilmurugan Ramalingam, Lalji Gediya, and Vincent C. O. Njar. "Abstract 2704: Simultaneous targeting of androgen receptor (AR) and Eukaryotic Initiation Factor 4E (eIF4E) dependent translation initiation by RAMBA Retinamides promotes apoptosis and impedes cell growth, cell proliferation and matrix invasion in androgen sensitive and castration-resistant prostate cancers." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2704.
Повний текст джерелаCarter, Julia H., Reed Spaulding, James A. Deddens, Bruce M. Colligan, Grant Lewis, Jackson O. Pemberton, Jeremy R. Graff, and Larry E. Douglass. "Abstract A28: Eukaryotic initiation factor 4E phosphorylation in human malignant melanoma." In Abstracts: AACR Special Conference on Advances in Melanoma: From Biology to Therapy; September 20-23, 2014; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.mel2014-a28.
Повний текст джерелаЗвіти організацій з теми "Eukaryotic initiation factor eIF4GI"
Fonseca, Bruno. Studying the Role of Eukaryotic Translation Initiation Factor 4E (eIF4E) Phosphorylation by MNK1/2 Kinases in Prostate Cancer Development and Progression. Fort Belvoir, VA: Defense Technical Information Center, June 2013. http://dx.doi.org/10.21236/ada612330.
Повний текст джерелаvon Arnim, Albrecht G. Eukaryotic initiation factor 3 (eIF3) and 5’ mRNA leader sequences as agents of translational regulation in Arabidopsis. Final report. Office of Scientific and Technical Information (OSTI), February 2015. http://dx.doi.org/10.2172/1169186.
Повний текст джерелаChamovitz, Daniel, and Albrecht Von Arnim. Translational regulation and light signal transduction in plants: the link between eIF3 and the COP9 signalosome. United States Department of Agriculture, November 2006. http://dx.doi.org/10.32747/2006.7696515.bard.
Повний текст джерела