Добірка наукової літератури з теми "Endosomal signalling"
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Статті в журналах з теми "Endosomal signalling"
Tzafriri, A. Rami, and Elazer R. Edelman. "Endosomal receptor kinetics determine the stability of intracellular growth factor signalling complexes." Biochemical Journal 402, no. 3 (February 26, 2007): 537–49. http://dx.doi.org/10.1042/bj20060756.
Повний текст джерелаCattaruzza, Fiore, Daniel P. Poole, and Nigel W. Bunnett. "Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease." Biochemical Society Transactions 41, no. 1 (January 29, 2013): 137–43. http://dx.doi.org/10.1042/bst20120343.
Повний текст джерелаEden, Emily R., Thomas Burgoyne, James R. Edgar, Alexander Sorkin, and Clare E. Futter. "The relationship between ER–multivesicular body membrane contacts and the ESCRT machinery." Biochemical Society Transactions 40, no. 2 (March 21, 2012): 464–68. http://dx.doi.org/10.1042/bst20110774.
Повний текст джерелаAlanko, Jonna, Anja Mai, Guillaume Jacquemet, Kristine Schauer, Riina Kaukonen, Markku Saari, Bruno Goud, and Johanna Ivaska. "Integrin endosomal signalling suppresses anoikis." Nature Cell Biology 17, no. 11 (October 5, 2015): 1412–21. http://dx.doi.org/10.1038/ncb3250.
Повний текст джерелаVillasmil, Michelle L., Vytas A. Bankaitis, and Carl J. Mousley. "The oxysterol-binding protein superfamily: new concepts and old proteins." Biochemical Society Transactions 40, no. 2 (March 21, 2012): 469–73. http://dx.doi.org/10.1042/bst20120012.
Повний текст джерелаMüller-Calleja, Nadine, Davit Manukyan, Antje Canisius, Dennis Strand, and Karl J. Lackner. "Hydroxychloroquine inhibits proinflammatory signalling pathways by targeting endosomal NADPH oxidase." Annals of the Rheumatic Diseases 76, no. 5 (November 30, 2016): 891–97. http://dx.doi.org/10.1136/annrheumdis-2016-210012.
Повний текст джерелаQiu, Shirley, and Marceline Côté. "From hitchhiker to hijacker: pathogen exploitation of endosomal phosphoinositides." Biochemistry and Cell Biology 97, no. 1 (February 2019): 1–9. http://dx.doi.org/10.1139/bcb-2017-0317.
Повний текст джерелаRodahl, Lina M., Susanne Stuffers, Viola H. Lobert, and Harald Stenmark. "The role of ESCRT proteins in attenuation of cell signalling." Biochemical Society Transactions 37, no. 1 (January 20, 2009): 137–42. http://dx.doi.org/10.1042/bst0370137.
Повний текст джерелаShelke, Ganesh Vilas, Yanan Yin, Su Chul Jang, Cecilia Lässer, Stefan Wennmalm, Hans Jürgen Hoffmann, Li Li, Yong Song Gho, Jonas Andreas Nilsson та Jan Lötvall. "Endosomal signalling via exosome surface TGFβ-1". Journal of Extracellular Vesicles 8, № 1 (20 вересня 2019): 1650458. http://dx.doi.org/10.1080/20013078.2019.1650458.
Повний текст джерелаMeenhuis, Annemarie, Carola Verwijmeren, Onno Roovers, and Ivo P. Touw. "The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor." Biochemical Journal 434, no. 2 (February 11, 2011): 343–51. http://dx.doi.org/10.1042/bj20101628.
Повний текст джерелаДисертації з теми "Endosomal signalling"
Yammine, Lucie. "La Lipocaline 2 : de son implication dans la régulation du transport endosomal de l'EGFR à la caractérisation fonctionnelle de son interactome Lipocalin-2 acts as an enhancer of EGFR signalling by promoting its cell surface recycling." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB027.
Повний текст джерелаChronic Kidney Disease (CKD) is characterized by a functional deterioration of kidney parenchyma. Transforming Growth Factor alpha (TGF-a) dependent activation of Epidermal Growth Factor Receptor (EGFR) participates to CKD onset and progression. In this context, it has been previously shown that Lipocalin 2 (Lcn2) mediates EGFR mitogenic effect, but the underlying intracellular mechanisms on EGFR pathway regulation by Lcn2 are yet to be discovered. Lcn2 is a 25 kDa protein that is expressed in many pathological conditions as in inflammation, cancer or kidney damage. During my thesis I wanted to better understand the intracellular mechanisms by which Lcn2 can regulate EGFR pathway. First I establish, in an in vitro model of kidney epithelial cells, that Lcn2 enhances EGFR recycling to the plasma membrane in steady state as well as after its activation by TGF-a. This allows for an increased activation of EGFR and its downstream targets. Conversely, Lcn2 inhibition induced a lysosomal degradation of TGF-a-stimulated EGFR. In order to gain insight into the mechanisms by which Lcn2 regulates EGFR trafficking, I demonstrate that a cytosolic fraction of Lcn2 binds the intracellular domain of activated EGFR during its journey in the late endosomes. In agreement, using a murine experimental model of CKD, I confirmed EGFR abundance decrease at tubular cell membrane in Lcn2 knock-out mice. Interestingly, I demonstrate that EGFR activation by TGF-a induces Lcn2 phosphorylation on Tyrosine residues. Furthermore, I establish that Lcn2 phosphorylation enhances the interaction between EGFR and Lcn2 and that it is necessary for inducing EGFR recycling to the plasma membrane. Moreover, an interactome analysis of Lcn2 protein interaction network unraveled new pathways in which Lcn2 could be involved. Indeed, putative partners of Lcn2 identified in this analysis are components of the cytoskeletal compartment and of the vesicular transport machineries. This interactome analysis allowed me to show that Lcn2 could be implicated in phenomena such as focal adhesion assembly, which could be linked to Lcn2 role on cell migration, or primary cilia length, an important actor in CKD
Albrecht, Tobias. "Modulation of insulin signalling and calcium homeostasis by endosomes in pancreatic beta-cells." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52750.
Повний текст джерелаMedicine, Faculty of
Graduate
Книги з теми "Endosomal signalling"
Conn, P. Michael, and Saurabh Jha. Endosome Signalling. Elsevier Science & Technology Books, 2014.
Знайти повний текст джерелаConn, P. Michael, and Saurabh Jha. Endosome Signalling. Elsevier Science & Technology Books, 2014.
Знайти повний текст джерелаЧастини книг з теми "Endosomal signalling"
Bergeron, J. J. M., W. H. Lai, D. G. Kay, J. J. Doherty, M. N. Khan, and B. I. Posner. "The Endosomal Apparatus and Transmembrane Signalling." In Advances in Experimental Medicine and Biology, 213–24. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4757-1980-2_14.
Повний текст джерелаPosner, Barry I., and John J. M. Bergeron. "Endosomes and Cell Signalling." In Molecular Mechanisms of Membrane Traffic, 237–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-662-02928-2_47.
Повний текст джерелаPriadharsini, K., D. Manikandan, Sajeer Koolath, G. Rajasekhar Reddy, and S. U. Mohammed Riyaz. "Lung Recruitability in COVID-19." In An Epidemiological Update on COVID -19, 49–54. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815050325122010010.
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