Дисертації з теми "Elegans synapse"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-17 дисертацій для дослідження на тему "Elegans synapse".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Thompson-Peer, Katherine Louise. "Transcriptional Regulation of Synapse Remodeling in C. elegans." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10131.
Повний текст джерелаTrujillo, Gloriana Victoria. "RPM-1 suppressors Act in synapse formation and axon termination in Caenorhabditis elegans." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3404415.
Повний текст джерелаTitle from first page of PDF file (viewed June 3, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (leaves 89-95).
Philbrook, Alison M. "Molecular Mechanisms Underlying Synaptic Connectivity in C. elegans." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/966.
Повний текст джерелаGendrel, Marie. "Analyse de l'agrégation des récepteurs de l'acétylcholine à la jonction neuromusculaire de Caenorhabditis elegans." Paris 6, 2009. http://www.theses.fr/2009PA066738.
Повний текст джерелаOliver, Devyn. "Constructing and Maintaining the Nervous System: Molecular Insights Underlying Neuronal Architecture, Synaptic Development, and Synaptic Maintenance Using C. elegans." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1123.
Повний текст джерелаDesbois, Muriel. "Dynamic synaptic changes revealed by a novel trans-synaptic method to visualize connections in vivo in C. elegans." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066157/document.
Повний текст джерелаThe nervous system is a complex network that senses and processes information and is essential for the survival of both vertebrates and invertebrates as it is involved in behavior responses. Information within the network is transmitted through specialized cell-cell contacts, including synaptic connections. Importantly, the network is not static and is believed to change during development and learning, as well as during pathological or normal age-related decline. Studying the nervous system in vivo requires the use of animal models such as Caenorhabditis elegans. Understanding of behavior and development requires visualization and analysis of synaptic connectivity. However, existing methods are laborious and may not depend on trans-synaptic interactions, or otherwise ‘trap’ the synapses by fixing the connections, thus precluding dynamic studies. In order to study synaptic modifications, we developed a new transgenic approach for in vivo labeling of specific connections in C. elegans, called iBLINC (in vivo Biotin Labeling of INtercellular Contacts). iBLINC involves the biotinylation of an acceptor peptide (AP) by the Escherichia coli biotin ligase BirA. Both are fused to two interacting post- and pre-synaptic proteins, respectively. The biotinylated acceptor peptide fusion is detected by a monomer streptavidin fused to a fluorescent protein that is transgenically expressed and secreted into the extracellular space. The method is directional, bright and dynamic. Moreover it correlates well with electron micrograph reconstruction. Using this new technique to observe synapses, which are part of the thermosensory circuitry of C. elegans, during aging, we could conclude that the connection pattern varies with age and within a population. Changes of the number and size of the synapses were observed during aging. Some segments of the synaptic region seem to be more affected than others by the aging process. Those results were corroborated by using a GABAergic pre-synaptic marker which allowed us to visualize a decline of the vesicle number with aging. In summary, in this thesis I explained a new in vivo trans-synaptic method to visualize synapses in C. elegans. Then I demonstrated that a natural decline in the number of synapses as well as the number of vesicles occurs during aging
Law, Ka Lun. "Identification and characterization of suppressors of nonhomologous synapsis during «C. elegans» meiosis." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103507.
Повний текст джерелаLa ségrégation des chromosomes lors de la méiose I dépend de l'alignement initial de chromosomes homologues, la mise en place du complexe synaptonémal (SC), et la formation de chiasmas entre les homologues. Des études antérieures ont démontré que HIM-3, une composante de l'axe du chromosome méiotique, est requis pour ces processus par le recrutement des protéines autosomique centre de liaison (ZIMS) et des composants SC comme SYP-1. Le him-3(vv6) mutation se traduit par la substitution d'un résidu hautement conservé dans le domaine HORMA, considérés comme des médiateurs des interactions protéine-protéine. him-3(vv6) germlines mutant affichage des axes immature et discontinue à la méiose précoce et le centre autosomique appariement (PC) protéine ZIM-3 ne parvient pas à localiser correctement vers les centres de liaison, malgré le fait que HIM-3vv6 est correctement exprimé et localisées; mutants présentent des défauts graves dans homologue alignement, non homologue vaste synapse et des défauts dans la formation des chiasmas, entraînant une mortalité élevée embryonnaires (emb) et une incidence élevée de sexe masculin (him) comme des conséquences de phénotype missegregation chromosome. Pour identifier les protéines qui interagissent avec HIM-3 au début du processus de la méiose et d'autres protéines qui fonctionnent dans la voie HIM-3, un crible EMS à base de suppresseur a été réalisée avec l'allèle vv6 et un suppresseur de forte extragénique, vv39 a été isolé. vv39 a été identifié comme un nouvel allèle de cct-4, qui code pour la sous-unité delta du complexe chaperonine type II. En germlines de type sauvage, cct-4 est localisée dans le cytoplasme et le noyau, ce qui indique qu'il a un rôle nucléaire. En germlines appauvri pour cct-4 ou d'autres sous-unités du complexe du CCT, le montage axe est retardée, ZIM-3 ne parvient pas à être recrutés pour les PC et SYP-1ne parvient pas à localiser les axes, ce qui suggère que le complexe CCT est nécessaire pour la morphogenèse des axes chromosome méiotique compétente pour les processus de la méiose. En him-3(vv6); cct-4 (vv39) mutants, la morphogenèse en temps opportun des axes chromosome est semble être restauré et il est accompagné par ZIM-3 de recrutement pour les PC, l'alignement homologue accrue et une réduction non homologue synapsis. Ces résultats suggèrent collectivement que CCT-4 est un médiateur de axes morphogenèse par pliage de l'axe composante HIM-3 ou des interacteurs du HIM-3. Cette étude est la première à donner un aperçu sur la fonction de chaperonine moléculaire dans la médiation des processus méiotique. Il serait intéressant à l'avenir d'approfondir l'étude du complexe nucléaire chaperonine CCT et de ses clients à en apprendre davantage sur leur rôle dans les processus de la méiose.
Richard, Magali. "Analyse de la jonction neuromusculaire cholinergique par une approche génétique chez Caenorhabditis elegans." Paris 6, 2012. http://www.theses.fr/2012PA066336.
Повний текст джерелаNicotinic acetylcholine receptors (AChRs) belong to a widely conserved family of transmembrane protein implicated in numerous physiological and pathological processes in human. Control of AChR expression and localisation is essential for the synapse formation, stability and plasticity. I used a genetic approach in the nematode Caenorhabditis elegans to identify novel genes required for biosynthesis and synaptic localization of AChRs. First, I performed a visual screen for genes required for proper localization of AChRs at neuromuscular junction (NMJ). After inactivation of more than 1000 evolutionarily conserved genes by RNA interference, I validated 18 candidates required for cholinergic NMJ function. Second, I realized the functional and molecular characterization of the novel gene emc-6. Emc-6 mutant was identified in a screen for mutants partially resistant to levamisole, a cholinergic agonist. EMC-6 is a small protein widely conserved from plant to human and localized in the endoplasmic reticulum (ER). When EMC-6 is absent, AChR subunits are targeted to degradation. EMC-6 belongs to the conserved ER Membrane protein Complex (EMC). In C. Elegans, RNAi against EMC members causes developmental defects, decreased AChR expression and activation of ER stress reporters. These results suggest that EMC protects AChR subunit from degradation and is required for ER homeostasis in metazoans in physiological conditions
Barbagallo, Belinda. "Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/728.
Повний текст джерелаBarbagallo, Belinda. "Activity Regulates Neuronal Connectivity and Function in the C. elegans Motor Circuit: A Dissertation." eScholarship@UMMS, 2007. http://escholarship.umassmed.edu/gsbs_diss/728.
Повний текст джерелаHuang, Yung-Chi. "Behavioral and Functional Analysis of a Calcium Channelopathy in Caenorhaditis elegans." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/893.
Повний текст джерелаHuang, Yung-Chi. "Behavioral and Functional Analysis of a Calcium Channelopathy in Caenorhaditis elegans." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/893.
Повний текст джерелаWatkins, Nicholas Arthur. "The F-box Protein FSN-1 Governs Presynaptic Development in Caenorhabditis elegans." Thesis, 2011. http://hdl.handle.net/1807/29638.
Повний текст джерелаHwang, Christine. "The Presynaptic F-box Protein FSN-1 Regulates Synapse Development via Retrograde Insulin Signaling in Caenorhabditis elegans." Thesis, 2010. http://hdl.handle.net/1807/24582.
Повний текст джерелаKittelmann, Maike. "Synaptic Ultrastructure and Regulation of Synaptic Transmission in Caenorhabditis elegans." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F0C7-D.
Повний текст джерелаNarayan, Anusha. "Transfer at C. elegans Synapses." Thesis, 2010. https://thesis.library.caltech.edu/5848/1/thesis.pdf.
Повний текст джерелаWatson, Joseph Daniel. "Gene expression profiles of the C. elegans nervous system reveal targets of the synaptic protein RPM-1." Diss., 2007. http://etd.library.vanderbilt.edu/ETD-db/available/etd-07232007-134517/.
Повний текст джерела