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Статті в журналах з теми "Effet hypotenseur de l'apéline"
Zahoui, S. O., N. G. Zirihi, Y. T. Soro, and F. Traore. "Effet hypotenseur d’un extrait aqueux de Zanthoxylum zanthoxyloides (Lam.) Waterman (Rutaceae)." Phytothérapie 8, no. 6 (December 2010): 359–69. http://dx.doi.org/10.1007/s10298-010-0587-4.
Повний текст джерелаZahoui, O. S., T. Y. Soro, K. M. Yao, S. A. Nene-Bi, and F. Traoré. "Effet hypotenseur d’un extrait aqueux de Combretum micranthum G. Don (Combretaceae)." Phytothérapie 15, no. 3 (July 11, 2016): 138–46. http://dx.doi.org/10.1007/s10298-016-1053-4.
Повний текст джерелаE., Ngolo, Etou Ossibi A.W., Epa C., Loubanou C.A. C., Samba Ndossi A.S.F., Ouamba J.M., and Abena A.A. "Effet hypotenseur de l’extrait aqueux de la recette à base de Brillantaisia patula T. Anderson (Acanthaceae) et de Desmodium velutinum (Willd) D.C (Fabaceae) chez lerat." International Journal of Multidisciplinary and Current Research 6, no. 6 (November 16, 2018). http://dx.doi.org/10.14741/ijmcr/v.6.6.20.
Повний текст джерелаДисертації з теми "Effet hypotenseur de l'apéline"
Alvear-Perez, Rodrigo. "Voies de signalisation activées lors de la stimulation du récepteur de l'apéline, responsables de l'effet hypotenseur de l'apéline." Electronic Thesis or Diss., Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCB021.
Повний текст джерелаApeline is a vasoactive neuropeptide which plays a crucial role in maintaining water balance and cardiovascular functions. Laboratory studies on the effects of Aperlin-17 (K17F) and the K16P apelin fragment, corresponding to K17F deletion from phenylalanine (Phe) at its C-terminal part have shown the presence of this Phe is necessary for apelin to induce internalization of the Apelin receptor. Also cause a decrease in blood pressure. Subsequently, in the CHO cells expressing stably the murine receptor of the Apelin that the internalization of the Apelin receptor induced by K17F resulted in the activation of a second signaling pathway which is independent of the Gi protein, but dependent on beta-arrestin. This corresponds to the MAP kinase pathway (Mitogen Activator Protein Kinase), which could be involved in the hypotensive effect of the Apelin. My work consisted of characterizing a physiological model such as the rat kidney juxtamedullary afferent arterioles (JMAA), to study if the signaling pathway mediated by beta-arrestin was involved in the vasodilatory effect of K17F. Knowing that AngII induces vasoconstriction by increasing intracellular calcium mobilization ([Ca2+]i), we have showed by measuring variations in arteriolar diameter and [Ca2+]i, that when the Gi signaling pathway is blocked by pertussis toxin (PTX), the vasorelaxant effect induced by K17F is not modify. This data suggests that the vasorelaxing effect of K17F on AngII pre-contracted JMAAs is Gi-independent protein. In the presence of PTX and various internalization inhibitors the vasorelaxant effect induced by K17F on AngII-pre-contracted JMAAs is completely blocked. In addition, no significant decrease in [Ca2+]i mobilization is observed in the presence of PTX and these inhibitors, when K17F is applied to the plateau phase of the AngII-induced calcium response. This is in line with our hypothesis, that the vasorelaxing effect of K17F is Gi-independent protein and beta-arrestin-dependent. ApelineR is a potential therapeutic target for the treatment of heart failure and water retention. Knowing that the half-life of the aperitif in the bloodstream is approximatly one minute. Another aspect of my thesis was to develop metabolically stable K17F analogues by two different strategies. First, we have substituted each of the residues of the aperitif with its D-series enantiomer or a synthetic amino acid. Secondly, we added a fluoroalkyl chain to the N-terminal end of K17F. These two strategies have enabled us to obtain several compounds, the most active of which are P92 and LIT01-196. These retain pharmacological properties identical to those of K17F and have a plasma half-life significantly higher compared to the endogenous peptide. These two analogues have been shown to be active in vivo with the ability to reduce blood pressure and reduce vasopressin secretion in the blood leading to an increase in aqueous diuresis
Sosner, Philippe. "Effet hypotenseur de nouvelles modalités d’exercice physique chez le patient hypertendu de grade 1 ou 2." Thesis, Poitiers, 2016. http://www.theses.fr/2016POIT2260.
Повний текст джерелаHigh blood pressure is a common disease with many cardiovascular complications. Inactivity is also an important cardiovascular risk factor, and the regular practice of physical activity (PA) decreases very significantly this risk, more than the single improvement of blood pressure (BP). Therefore, PA is recommended for its contribution on the management of hypertension. The “acute” BP fall following a bout of exercise contributes to the “chronic” antihypertensive effect of physical training, by inducing both functional and structural adaptations (BP regulation systems and components of arterial wall, respectively). Face to the many modalities of PA (aerobic, strength, continuous or intermittent mode, outdoor, indoor or in swimming-pool) and to the desires and availabilities of the patient, we aimed to assess, in hypertensive individuals, the effect of new modes (high-intensity intermittent exercise (HIIE), cycling in immersed condition) using preferably ambulatory BP monitoring measures. Thereby, our research identified, through a meta-analysis and 3 clinical studies, the following results:A- regarding PA characteristics : 1- a BP decrease following one bout of HIIE, 2-week HIIE training (thrice a week) and 9-month HIIE training (twice a week) in a combined lifestyle program;2- an additional BP improvement in up-to-the chest immersed condition; 3- an improvement in arterial stiffness (pulse wave velocity, PWV);B- regarding patient’s characteristics: favorable moderators such as a resting BP ≥135/85 mm Hg, or the association of diet intervention. These results should contribute to improve prescription of PA in hypertensive individuals
Chamberland, Caroline. "Action inotrope positive de l'apéline liée à l'augmentation de l'amplitude du courant sodique dans les myocytes cardiaque de chien." Mémoire, Université de Sherbrooke, 2008. http://savoirs.usherbrooke.ca/handle/11143/3965.
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