Дисертації з теми "Early phase studies"
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Dahiya, Hema. "Shakespeare studies in Colonial Bengal : the early phase." Thesis, Sheffield Hallam University, 2011. http://shura.shu.ac.uk/19526/.
Повний текст джерелаFreeman, Georgina. "Publication bias and quality of reporting of Pharmacodynamic Studies utilizing invasive research procedures within early phase cancer trials." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110657.
Повний текст джерелаLes procédés de recherche effractifs, tels que la biopsie dans le cadre d'études pharmacodynamiques, n'ont souvent aucun avantage pour le patient-bénévole en ce qui concerne le diagnostic ou la prise en charge clinique. Le recours à ces procédés n'est souvent fondé que sur l'idée de la valeur des connaissances (ce en quoi ils aideront d'éventuels patients futurs) plutôt que sur l'avantage direct pour le patient.Cette thèse propose d'étudier la justification du recours à des procédés de biopsie effractive dans la recherche sur le cancer par la production de connaissances. Nous proposons comme prémisse que la recherche sur les êtres humains ne peut produire de connaissances de valeur que dans la mesure où les résultats de la recherche sont présentés de manière à permettre à la communauté scientifique élargie de les utiliser à des fins de recherches ultérieures. Nous avons étudié l'interruption de l'accumulation de connaissances de valeur selon deux critères empiriques : la publication et la qualité des renseignements. Cette thèse se concentre particulièrement sur la publication et la qualité des renseignements dans les sous-études pharmacodynamiques contenues dans les essais cliniques de premières phases dans le domaine du cancer. Ces essais visent à mesurer l'innocuité et les effets toxiques potentiels d'un nouveau médicament de recherche, ainsi que la réaction de la tumeur. Les sous-études pharmacodynamiques évaluent les effets du médicament sur ses « cibles » (un enzyme ou une voie enzymatique). Nos résultats indiquent que pour 37% des essais cliniques de premières phases qui comprennent des sous-études pharmacodynamiques utilisant la biopsie, toutes les données pharmacodynamiques ont été publiées. À la suite d'une enquête auprès d'auteurs d'études, les obstacles les plus communs sont les « considérations d'ordre stratégique quant à la publication », dans le cas d'études où on juge que les résultats n'apportent rien de nouveau ou sont sans intérêt, contradictoires ou difficiles d'interprétation, et lorsque des « différends d'ordre scientifique » empêchent la publication de résultats pharmacodynamiques (59% des répondants). La qualité des renseignements varie grandement à travers les études et on remarque que certaines données importantes pour le contrôle de la qualité ne sont qu'irrégulièrement signalées, dont les résultats de tous les tests planifiés (78% des essais), l'évaluation des résultats à l'insu (43% des essais), les dimensions des tissus prélevés (38% des essais) et la description du cheminement du patient durant la section pharmacodynamique de l'étude (62% des essais). Lorsque l'analyse pharmacodynamique est le but premier de l'essai ou que celui-ci comprend un recours obligatoire à la biopsie, l'étude tend considérablement à être de meilleure qualité. La prépondérance de résultats positifs (61% des études) suggère peut-être un biais de publication. Compte tenu des résultats de notre recherche, nous proposons que les investigateurs d'études et les membres de comités d'éthique indépendants évaluent de manière critique les objectifs en matière de recrutement des patients, de prélèvement des tissus et de validation des essais pharmacodynamiques. De plus, les comités d'éthique indépendants et les investigateurs doivent s'assurer que tout laboratoire visant le prélèvement et l'analyse de tissus par la biopsie possèdent les ressources financières, humaines et matérielles nécéssaires pour compléter une étude pharmacodynamique validée. La recommandation principale de cette thèse consiste en l'élaboration d'une ligne directrice formalisée, comparable à CONSORT ou REMARK, pour la publication d'études pharmacodynamiques. Nous recommandons également que les auteurs d'études et les éditeurs de revues envisagent de publier indépendamment les résultats pharmacodynamiques ou d'inclure des matériaux supplémentaires afin de permettre une description méthodologique plus riche de la recherche pharmacodynamique.
Smirat, Daniel. "Financial aspects facing start-ups during the go-to-market phase : Case studies of Swedish start-ups." Thesis, Luleå tekniska universitet, Institutionen för ekonomi, teknik och samhälle, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-69514.
Повний текст джерелаWainwright, Elizabeth N. "The interpretation and delivery of the Welsh Foundation Phase and its contribution to physical literacy." Thesis, University of Bedfordshire, 2014. http://hdl.handle.net/10547/576443.
Повний текст джерелаNhacolo, Arsénio Quingue [Verfasser], Werner [Akademischer Betreuer] Brannath, Werner [Gutachter] Brannath, and Martin [Gutachter] Posch. "Bias and precision in early phase adaptive oncology studies and its consequences for confirmatory trials / Arsénio Quingue Nhacolo ; Gutachter: Werner Brannath, Martin Posch ; Betreuer: Werner Brannath." Bremen : Staats- und Universitätsbibliothek Bremen, 2018. http://d-nb.info/1170321046/34.
Повний текст джерелаSohail, Aaqib [Verfasser], Frank [Akademischer Betreuer] Pessler, and Armin [Akademischer Betreuer] Braun. "Use of the human lung tissue explant model for functional biomarker studies in the early phase of infections / Aaqib Sohail ; Akademische Betreuer: Frank Pessler, Armin Braun ; Twincore, Zentrum für Experimentelle und Klinische Infektionsforschung." Hannover : Bibliothek der Medizinischen Hochschule Hannover, 2020. http://d-nb.info/1217856404/34.
Повний текст джерелаMayta, Raul E. "Socializing Housing Phased Early Response to Impromptu Migrant Encampments In Lima, Peru." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002710.
Повний текст джерелаAnanthakrishnan, Revathi Nayantara. "On the designs of early phase oncology studies." Thesis, 2017. https://hdl.handle.net/2144/27175.
Повний текст джерела2019-12-01T00:00:00Z
Nagpal, Anjali. "Exploring Determinants of Execution in Early Phase Clinical Studies with Cell Therapies in Stroke." Thesis, 2019. http://hdl.handle.net/2440/119953.
Повний текст джерелаThesis (Ph.D.) -- University of Adelaide, Adelaide Medical School, 2019
Hsieh, Tien-Hao, and 謝天晧. "The early phase of protostars and proto-brown dwarfs: Studies of Very Low Luminosity Objects (VeLLOs)." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/yngn28.
Повний текст джерела國立清華大學
天文研究所
104
My thesis project aims at understanding the natures of low mass protostars and proto-brown dwarfs at early evolutionary stage. A new category of Young Stellar Objects (YSOs), Very Low Luminosity Objects (VeLLOs), are newly discovered and defined by their low internal luminosity (Lint<0.1Lsun). The low luminosity infers that VeLLOs host a substellar mass central object at the present time and thus can be interpreted as a very young protostar or low mass protostar. This low luminosity also provides a constraint on their accretion luminosity as well as the accretion rate, suggesting VeLLOs are at a quiescent accretion phase. This thesis consists of four papers: (i) For the first paper, we develop a new identification method of YSOs to identify faint protostars in order to find more VeLLOs. Applying this method to the Spitzer archival data in five nearby molecular clouds, we identify 322 (28%) new YSO toward the lower end of the luminosity function compared with previous works. Based on this method, we further find seven VeLLOs in these molecular clouds. (ii) We study the chemical and dynamical properties of 15 selected Low Luminosity Objects (Lint<0.2Lsun) through molecular line emissions at millimeter/submillimeter wavelengths. We found that LLOs could have wide variety in their parent cores and tend to be at an very early evolutionary stage. (iii) We present a detailed investigation on the protostellar outflow driven by a unique VeLLO, IRAS 16253--2429. Our results suggest that IRAS 16253--2429 is very likely a proto-brown dwarf binary system. (iv) Using CFHT, we make an infrared outflow survey toward 20 LLOs. The outflows are detected in 12 LLOs (including 4 from Spitzer) and the outflow opening angles are widening as the core evolves as expected.
CHANG, CHENG HUNG, and 張正宏. "The Studies of Asthma-Relieving Decoction on Early and Late Phase Bronchoconstriction and Airway Leukocyte Infiltration after Ovalbumin Challenge of Nonanesthetized Guinea Pigs." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/77493219059650058537.
Повний текст джерела中國醫藥學院
中國醫學研究所
84
Bronchial asthma is a worldwide intractable disease. The prevalence of bronchial asthma in school children has increased more than four fold inTaipei over the last twenty years. The acute toxic effect, treatment effect, prevention of sensitization and prevention of anti-sensitization of Asthma-Relieving Decoction (Ding Chuan Tang) were screened. This study will be helpful in establishing an optimal model to screen the effect of Chinese medicinals and herbal medicines for allergic asthma, explaining the clinical effect of Asthma-Relieving Decoction (Ding Chuan Tang), and researching the pharmacologic mechanism of Asthma-Relieving Decotion (Ding Chuan Tang). The animals used in this study, 216 male Dunkin-Hartley guinea pigs were randomized equally into six groups: (1) Experiment group one-treated 30minutes before challenge. (2) Experiment group two-treated 5 hours after challenge. (3) Experiment group three-treated 24 hourst and 2 hours before challenge. (4) Experiment group four- treated once daily, three days before sensitization till the day of challenge. (5) Control group-sensitized and challenged, no treatment. (6) Healthy group- no sensitization, challenge or treatment. Every group consisted of six guinea pigs in six different observational time points. Ovalbumin was inhaled to give guinea pigs asthma. Body plethysmography, bronchoalveolar lavage analysis, pathologic finding in lung (H.E. stain), and one-way ANOVA were applied to evaluate the effect of Asthma-Relieving Decoction (Ding Chuan Tang) on airway resistance, inflammatory cells, and the change in lung tissue. The results revealed that all the P/V ratios (reprensented for airway resistance) in control group significantly increased over than Ŗ". In control group, the neutrophil rates significantly increased in early asthmaticreaction; the eosinophil rates significantly increased in late asthmatic reaction. For pathologic biopsy, the pulmonary inflammatory cell sinfiltration and the constriction of airway smooth muscles were reduced in all experiment groups. The P/V ratios, neutrophil rates, and eosinophil rates of experiment group one and two significantly decreased when compared with control group in the early asthmatic reaction showed the "therapeutic effect" of Asthma-Relieving Decoction (Ding Chuan Tang). The P/V ratios, neutrophil rates, and eosinophil rates of experiment group three significantly decreased when compared with control group in the early and late asthmatic reactions showed the "prevention of sensitization" of Asthma-Relieving Decoction (Ding Chuan Tang). The P/V ratios, neutrophil rates and eosinophil rates of experiment group four also significantly decreased when compared with control group in the early and late asthmatic reactions showed the "prevention of anti-sensitization" of Asthma-Relieving Decoction (Ding Chuan Tang). In summary, Asthma-Relieving Decoction (Ding Chuan Tang) was effective to relieve the early and late asthmatic reactions and reduce the pulmonary inflammatory cells infiltration. The possible efficient mechanisms could be through β2-adrenoceptor agonist, some degree of anti-inflammation, primary effector cells stablization and inhibition of IgE synthesis.
Yeh, Tsung-Jen, and 葉宗仁. "The Studies of Ma-Xing-Gan-Shi Tang on early and late phase bronchoconstriction and airway leukocyte infiltration after ovalbumin challenge of nonanesthetized Guinea pigs." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/86975303258638435117.
Повний текст джерела中國醫藥學院
中國醫學研究所
83
Asthmatic allergy is one of the most common chronic diseases, especially in the field of pediactrics in Taiwan.According to the methods of Hsieh K.H., Hutson et.al, a guinea pig model of asthma has been established. We used this animal model to examine the effects of Ma-Xing-Gan-Shi Tang administered before and after allergen challenge on the EAR and the LAR, and the associated interaction of the airway with leukocytes as well as the histopathological changes. The results showed (1) The experimental guinea pigs showed a decrease in the interaction of the airway between alto 6hr period (p<0.05) on the pulmonary function study. (2) On the BAL study,the neutrophils in the experimental pigs have a lower concentration than the control pigs during the 1~6hrs period(p<0.01); At 48~72hrs, eosinophils have not significantly changed. The neutrophils have no significant difference between the treated and naive groups during the 1~6hrs period, but at times 48~72hrs the eosinophils have significantly increased (p<0.01). (3) On the histopathological studies, we did not find neutrophil infiltration significantly increased in the bronchial area during 1~6hrs time period on the experimental guinea pigs. At time 48~72hrs, the eosinophil infiltration showed a significant increase. At time 1~6hrs, the neutrophil infiltration increased around tracheal and bronchial epithelial cells and mucosa. In the control guinea pigs, at time 48~72 hrs, eosinophil nfiltration was significantly increased. According to the results, the administration of MXGS does have an effect on asthma treatment. The mechanisms of MXGS could provoke theβ2-selective adrenoceptor, relieve the con traction of bronchial smooth muscle,and decrease the degranulation of mast cells. Further investigations will focus on the mechanisms of MXGS.
Chang, Jau-Dong, and 張朝棟. "The Studies of Ma-Xing-Gan-Shi Tang on Early and Late Phase Bronchoconstriction and Airway Leukocyte Infiltration after HDM( D.P) Challenge of Sensitized Guinea Pigs." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/23409087064201291026.
Повний текст джерела中國醫藥學院
中國醫學研究所
84
Allergic asthma is one of the most common chronic diseases in the field of pediatrics in Taiwan. According to an epidemiology study of asthma in school children in Taipei, the prevalence of asthma increased from 1.30% in 1974 to 10.79% in 1994. More than 90% of children with asthma has positive skin test responses to house dust mite (HDM), and Dermatophagoides Pteronyssinus (D.P) was found to be dominant species. The treatment for asthma has been well documented in Chinese Medical history, but it doesn''t proved by the theory of Western Medicines. Hence, integrating western and traditional Chinese Medicines to imporve the efficiency of current treatments and to develop new treatments has rescently become a very importment topic. According to the methods of Tzuen-Ren Hsiue, Kue- Hsiung Hsieh et al, a guinea pig model of asthma has been established. Sixty (SPF) male Dunkin-Hartley guinea pigs, weighting 350-450g, were used throughout, thirty guinea pigs were senitized by injection (IP) of 100μg purified D.P protein powere on Day 0 and Day7. The allergic response to the asthma response was induced in thirty experimental guinea pigs by inhalation of 4mg/ml purified D.P protein for 10 mins. By contrast, the control group received saline inhalation for 10 mins. The pulmonary function after induction, at times 5 mins, 1, 2, 4, 6, 8, 12, 24, 48, 72 hrs were studied. The bronchoalveolar lavage and the histopathologic changes in guinea pig''s trachea and bronchiole at various time intervals after inhalation were investigated. The results showed: On the pulmonary mechanic function studies, the pressure of the airway during the allergic response was two times higher than before inhalation of purified D.P protein. The treated group had significantly increased neutrophils at 1 and 6 hrs after inhalation (P<0.001); at 24, 48 and 72 hrs, only eosinophils have increased as found in the bronchoalveolar lavage studies (P<0.001). On the histopathological studies, after purified D.P protein inhalation during the 1and 6 hrs period, the neutrophils have significantly increased around the airway smooth muscle and the direction toward the epithelium. From 24, 48 and 72 hrs, eosinophils increased signficantly. A stable animal model for studying asthma was established. We used this animal model to examine the effects of Ma-Xing-Gan-Shi Tang 《Treatise on Febrile Diseases》 administered before and after allergen challenge on the EAR and the LAR, and the associated interaction of the airway with leukocyts as well as the histopathological changes. The results showed: The experimental guinea pigs showed a decrease in the interaction of the airway between 1 and 6 hrs period on the pulmonary study. On the BAL study, the neutrophils in the experimental Guinea pigs have a lower concentration than the control Guinea pigs during the 1 to 6 hrs period (P<0.001); at 24, 48 and 72 hrs eosinophils have not significantly changes. The neu-trophils have no significant difference between the treated and naive groups during 1 and 6 hrs period, but at times 24, 48 and 72 hrs the eosinophils have significantly increased (P<0.001). On the histopathological studies, we did not find neutrophil infiltration significantly increased in the bronchial area during 1 to 6 hrs time period on the experimental guinea pigs, at times 24, 48 and 72 hrs, the eosinophil infiltration showed a significant increase. At time 1 to 6 hrs, the neutrophil infiltration increased around the airway smooth muscle and the direction toward the epithelium on the control guinea pigs, at times 24, 48 and 72 hrs, eosinophil infiltration was significantly increased. There was not any eosinophil and neutrophil infiltration around the airway smooth muscle and the direction toward the epithelium in the naive guinea pigs. According to the results, the administration of M-X-G-S does have an effect on asthma treatment, which could relieve the airway interaction in the early asthmatic guinea pigs, decrease airway inflammation and inhibit the activity of neutrophils around the tertiary brochial walls. The mechanism of M-X-G-S could provoke the β2-selective adrenoceptor, relieve the contraction of bronchial smooth muscle, and decrease the degranulation of mast cells. Further investigations will focus on the mechanism of M-X-G-S.
Enock, Rebecca Joe. "Supporting learners with autism in an early childhood centre for learning : a case study in inclusive education." Diss., 2011. http://hdl.handle.net/10500/7722.
Повний текст джерелаInclusive Education
M. Ed. (Inclusive Education)
Lotter, Jeanne-Marie. "The development of a reading culture in the Foundation Phase through comprehensive parent involvement." Diss., 2019. http://hdl.handle.net/10500/25463.
Повний текст джерелаDie studie getiteld ‘Die ontwikkeling van ‘n lees-kultuur in die Grondslagfase deur omvattende ouerbetrokkenheid’, het gefokus op die uitdaging om ‘n lees-kultuur te ontwikkel waar ‘n positiewe verandering in leerders se gevoel teenoor lees plaasvind, spesifiek lees vir genot, wanneer hulle ouers intensief betrokke is in die proses. Die navorsing is relevant aangesien baie van die leerders in die betrokke skool min tot geen belangstelling getoon het teenoor lees vir genot en het lees bloot as ‘n metode van studie beleef. Die metodologie wat in die studie gebruik was was kwalitatief van aard en het ‘n literatuurstudie, gevallestudies en semi-gestruktureerde onderhoude ingesluit. Die resultate van die studie het getoon dat die implementering van ‘n omvattende ouer-betrokkenheid model ‘n positiewe impak op die ontwikkeling van ‘n lees-kultuur gehad het. Die leerders was meer geneig om vir genot te lees wanneer hulle ouers deelgeneem het aan die lees-program en aan die pret lees-aktiwiteite tuis. Die leerders en hulle ouers wat aktief deelgeneem het aan die studie, het almal aangedui dat hulle ‘n groter waardering vir lees vir genot gehad het na die implementering van die program. Voorstelle om te help met die ontwikkeling van ‘n lees-kultuur is gemaak wat gebaseer was op die bevindings van die studie.
Thuto, e nang le sehlooho se reng 'Ho nts'etsa pele setso sa ho bala ka Sekhahla sa Motheo ka ho kenyeletsa ho kopanyelletsa ha motsoali', ho lebisitse phephetso ea ho hlaolela setso sa ho bala moo phetoho e ntle e etsoang ka maikutlo a barupeluoa ho bala le ka ho khetheha, ho bala bakeng sa thabo, ha batsoali ba ikakhela ka setotsoana mosebetsing ona. Phuputso e fumanoa e le ea bohlokoa ha ba bangata ho baithuti sekolong se kenang sekolo ba sa bontše thahasello ho bala bakeng sa thabo 'me ba bona ho bala feela e le mokhoa oa ho ithuta. Mokhoa o sebelisoang thuputsong ea lipatlisiso e ne e le mokhoa oa boleng bo botle 'me o kenyelelitse tlhahlobo ea lingoliloeng, lipatlisiso tsa liketsahalo le lipuisano tse sa tšoaneng. Liphello tsa phuputso li bontšitse hore ts'ebetso ea kakaretso ea ho kenya letsoho ho motsoali e na le tšusumetso e matla ho thehoa ha setso sa ho bala. Barupeluoa ba ne ba rata ho bala bakeng sa thabo ha batsoali ba bona ba ne ba kopanela ka bobeli mananeong a ho bala le mesebetsing e monate ea ho bala lapeng. Baithuti le batsoali ba ileng ba kenya letsoho thuputsong ena bohle ba bontšitse hore ba ananela haholo ho bala bakeng sa thabo ka mor'a kopo ea ts'ebetso. Ho itšetlehile ka liphuputso tsa lithuto, liphuputso li entsoe bakeng sa ntlafatso ea ho thusa tabeng ea ho theha setso sa ho bala likolong.
Educational Foundations
M. Ed. (Socio-Education)
Mahan, Sibongile Johannah. "Investigating Grade one teacher perceptions of reception year learner readiness." Diss., 2015. http://hdl.handle.net/10500/19113.
Повний текст джерелаCurriculum and Instructional Studies
M. Ed. (Specialisation in Curriculum Studies)