Дисертації з теми "Early life diet"
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Parrett, Alison M. "Development of colonic fermentation in early life." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390694.
Повний текст джерелаHeavey, Patricia. "New methodologies for studying diet and gut maturation in early life." Thesis, University of Ulster, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268569.
Повний текст джерелаGardner, David Stuart. "The early life programming of adult hypertension by glucocorticoids." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264896.
Повний текст джерелаD'Alessandro, Evan K. "Early Life Dynamics in Tropical Western Atlantic and Caribbean Snappers (Lutjanidae) and Barracudas (Sphyraenidae)." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/491.
Повний текст джерелаBirtwistle, Mark D. A. "The impact of diet in early life on adipose tissue growth and development in sheep." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/32926/.
Повний текст джерелаHenderson, Rowena Claire. "Early life histories : a study of past childhood diet and health using stable isotopes and enamel hypoplasia." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:a0ef07c7-7103-4a15-b825-0eae3e796882.
Повний текст джерелаNicholls, Rebecca A. "More than bones. An investigation of life, death and diet in later prehistoric Slovenia and Croatia." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/16764.
Повний текст джерелаThe Encounters and Transformations in Iron Age Europe (ENTRANS) Project, led by Ian Armit, with the Slovenian and Croatian principal investigators, Matija Črešnar and Hrvoje Potrebica. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 291827. The project is financially supported by the HERA Joint Research Programme (www.heranet.info) which is co-funded by AHRC, AKA, BMBF via PT-DLR, DASTI, ETAG, FCT, FNR, FNRS, FWF, FWO, HAZU, IRC, LMT, MHEST, NWO, NCN, RANNÍS, RCN, VR and The European Community FP7 2007-2013, under the Socio-economic Sciences and Humanities programme.
The Appendices A-H are not available online.
Lampert, Carine. "Isolamento social precoce, acesso crônico à dieta rica em sacarose e a programação do sistema dopaminérgico: susceptibilidade a psicoestimulantes e a alimento palatável na vida adulta." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/173286.
Повний текст джерелаChildhood and adolescence are sensitive periods of neuronal maturation, characterized by high plasticity of developing brain circuits, such as the mesolimbic dopaminergic system. Stressful experiences in these periods, such as social isolation (SI), can produce changes in these circuits and increase vulnerability to drug addiction and eating disorders throughout life. Considering that most of literature analyze long periods of social isolation, that are not good models for social stress in human societies, the objective of this study was to investigate the effects of a short post-weaning social isolation on mesolimbic dopaminergic system and the susceptibility to drug and food addiction in female Wistar rats in adulthood. Moreover, we also aimed to evaluate the role of a chronic high sugar diet (HSD) on these variables. It was observed that IS increased the locomotor response to a challenge with amphetamine (AMPH), as well as increased the immunocontent of dopamine transporter, the enzyme tyrosine hydroxylase, decreased the D2 dopamine receptor (D2R) and increased the parameters related to oxidative stress in dorsal striatum after the challenge. Interestingly, exposure to DRS prevented the effects of SI on locomotor response, but did not affect dopaminergic parameters. IS also decreased the basal immunocontent of D2R in the nucleus accumbens (NAc), and stimulated binge eating of high sweet food (Froot Loops®). HSD did not interfere with these parameters. We also observed that SI did not alter plasma corticosterone baseline levels after IS, whereas HSD induced a decrease in these levels. Excitatory postsynaptic currents (EPSC) indicated, as a preliminary result, that the exposure to a HSD reduced the rise time, indicating a more fleeting glutamatergic response. The findings of this study demonstrate for the first time that a short period of SI at a critical period of development is able to programme the mesolimbic dopaminergic system in order to increase susceptibility to both drug and food addiction. These results are possibly due, at least in part, to low basal levels of D2R in NAc and the higher stimulation of the dopaminergic system in striatum after a challenge with AMPH. The findings of this thesis suggest that stressful experiences such as social isolation during a critical period of development are able to permanently program the brain reward system and increase the susceptibility to additive behaviors in adult life. Identifying predisposing factors to this type of behavior is extremely important to prevent the development of drug addiction and/or eating disorders, to identify therapeutic targets and to enable the development of treatment strategies for these disorders.
Soualeh, Nidhal. "Évaluation des effets neuro-inflammatoires de l’exposition périnatale aux anguilles (Anguilla anguilla L.) contaminées naturellement aux polluants organiques persistants sur le comportement et les fonctions cognitives dans un modèle murin." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0288/document.
Повний текст джерелаSeveral lines of evidence indicate that early-life inflammation may predispose to mental illness in later-life. In our study, we investigated the impact of perinatal exposure to polluted eels on the brain and microglia inflammation in a lifespan approach as well as on the resignation behavior, the locomotor activity and the cognitive performances in the later life of male and female offspring mice. The effects of maternal standard diet (laboratory food) were compared to the same diet enriched with low, intermediate, or highly polluted eels. Our results showed a chronic brain inflammation in male and female offspring mice compared to controls, as assessed at the birth, up weaning, adulthood and middle-age. Activated microglia produced pro-inflammatory markers across the lifespan of male as well as female exposed offspring. The plasmatic level of myeloperoxidase was found to be significantly higher in both adult and middle-aged males and females vs. control offspring. However, high corticosterone levels were only found in adult male offspring mice perinatally exposed to polluted eels, suggesting a sex-selective dysregulation of the adult hypothalamic- pituitary- adrenal (HPA) axis. Sex selective differences were also found in adulthood, with regard to the offspring resignation behavior. Indeed, depressive-like symptoms were only found in adult male mice perinatally exposed to polluted eels. On the middle- age, sexe selective effects were found with regard to memory and locomotor activity. Indeed, hyperactive phenotype was only detected in females. In addition, impaired long-term memory was only detected in middle-aged females, perinatally exposed to either intermediately or highly polluted eels. This deficit was related to decreases in ERK1/2 and p65 activation, and acetylcholine levels that were only detected in female hippocampus exposed to either intermediately or highly polluted eels. In conclusion, our results indicated that early-life inflammatory insults were the plausible causative factor that programmed the behavior impairments and cognitive deficit in the later-life of offspring, and suggested that sex played an important role in the determination of nature of the appeared alterations
Zhang, Yongfang. "Amino acid metabolism and requirement in teleost during their early life stages and implications in fish formulated diets." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1199374737.
Повний текст джерелаLazzarotto, Viviana. "Conséquences à long-terme d’une alimentation à base de matières premières végétales sur la régulation du métabolisme énergétique et lipidique chez la truite arc-en-ciel : focus particulier sur les effets trans-générationnels et les stades précoces." Thesis, Pau, 2016. http://www.theses.fr/2016PAUU3002/document.
Повний текст джерелаIn the last years, the increase in aquaculture production has forced a change in fish feed composition, with increasing substitution of fish meal and fish oil by more available plant sources. In this context, the present PhD work aimed at analyzing the effects of different levels of concomitant dietary replacement of fish meal and fish oil by plant ingredients during the whole life cycle of rainbow trout (from first feeding to reproduction). This work showed for the first time that rainbow trout was able to survive, grow and produce viable offsprings, when fed a totally plant-based diet throughout the whole life cycle. Such dietary replacement resulted in drastic changes in tissues fatty acid profile of broodstock females. However, we found that trout was capable to synthetize n-3 long chain- polyunsaturated fatty acids (LC-PUFA) from dietary precursors and to transfer large amounts of these fatty acids in ova, so that an efficient reproduction can occur. We also studied the potential carry over generation effects of feeding broodstock a totally plant-based diet on progeny and their response to different diets at early stages, using molecular approaches, including the study of the whole body transcriptome. Considering the effects on progeny, the present study confirmed the capability of trout to survive and grow on a plant-based diet, but with slight differences in terms of weight. While no effects of maternal dietary background were observed before first feeding, except slightly lower body weight (-13%), significant effects on the transcriptome of whole body alevins appeared after 3 weeks of feeding. These effects of maternal nutritional history were mainly related to muscle growth/contraction and carbohydrate and energy metabolism. Irrespective of the maternal origin of progeny, first feeding diets containing plant ingredients resulted in up-regulation of genes involved in AA/protein and cholesterol metabolism, as well as in changes in the expression of genes involved in carbohydrate metabolism. Finally, the effects of long-term feeding trout plant-based diets were also studied in juveniles (10g) and ongrowing fish (250-350g), mainly focusing on intestine and liver gene expression. The long term trial in juveniles highlighted subtle effects on both intestinal and hepatic gene expression (transcriptome), mainly related to LC-PUFA and cholesterol biosynthetic pathways, which were enhanced in fish fed the plant based diets. This transcriptional pattern was maintained in ongrowing fish. Genes involved in protein catabolism, carbohydrate metabolism and trafficking were also affected by plant-based diets in juveniles, but these results were not fully confirmed in ongrowing fish. Overall, the results of the present thesis allowed extending the use of diets with high replacement rates of fish meal and fish oil to the whole life cycle of fish, including broodstock and early stages. Adjustments of the feed-formula are still needed to further optimize reproductive and growth performance
Zhang, Yongfang. "Amino acid metabolism and requirement in teleost during their early life stages and implications in fish formulated diets." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1199374737.
Повний текст джерелаPatton, Ashley. "Characterization of the Very Early Development of High Fat Diet-induced Non-alcoholic Fatty Liver Disease (NAFLD) and Efficacy of Novel Therapeutics for its Treatment." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1521811677550828.
Повний текст джерелаDaniels, Carly. "Optimisation of the rearing diets for early life stages of the European lobster, Homarus gammarus, to enhance growth, survival and health using biotic dietary supplements." Thesis, University of Plymouth, 2011. http://hdl.handle.net/10026.1/551.
Повний текст джерелаRaga, Emmanuelle. "Le Banquet et la "transformation du monde romain": entre Romanitas, Barbaritas et Christianisme :espace romain occidental, IVe-VIe siècle." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209918.
Повний текст джерела
La mia tesi si incentra sulla questione della trasformazione della pratica classica del banchetto nel confronto, da una parte con la nuova situazione sociale e politica dovuta all’insediamento dei regni post-romani, e, dall’altra, con l’intensificazione della cosiddetta “cristianizzazione” del mondo romano. La tesi riguarda lo spazio romano occidentale (cioè Gallia, Italia, Spagna) a partire dal momento in cui si diffonde la grande moda dell’ascetismo orientale dalla seconda metà del IV secolo. La questione principale della tesi, che occupa i capitoli tre e quattro, riguarda il discorso cristiano e ascetico sull’alimentazione e poi le risposte date dai gruppi sociali il cui uso del banchetto è documentato a sufficienza, in fatti specie gli aristocratici, il mondo monastico, e gli eremiti. I due primi capitoli riguardano, rispettivamente, la pratica del banchetto classico nella tarda antichità e la questione della presenza “barbara” e dell’immagine del mangiatore barbaro in quei secoli. La conclusione della tesi si colloca alla fine del VI secolo, in un momento in cui il mondo romano è indubbiamente trasformato.
My doctoral thesis concentrates on the question of the transformation of the classical banquet through the encounter with, on the one hand, the new sociopolitical situation due to the migration and installation of the new successor kingdoms ;and on the other hand, with the intensification of the Christianization of the Roman world. My research focuses on the Western Roman world (Gaul, Italy and Spain) from the moment in which the eastern ascetic discourse spreads widely in the West in the second half of the 4th century, causing what Robert Markus calls “The end of Ancient Christianity”. The main question of my thesis regards the Christian and ascetic discourse on food practices and the answers given by the social groups who’s uses of the banquet is documented enough. In this case, the aristocrats (within which the bishops), the monastic communities and the hermits. The second question taken into consideration in my thesis is the one presented by the “barbarian” presence and the literary image of the barbarian eater in these centuries of socio cultural transformation. The terminus ante quem of my research is placed at the end of the 6th century, in a undoubtly transformed Roman world.
Doctorat en Histoire, art et archéologie
info:eu-repo/semantics/nonPublished
Duclaux-Loras, Rémi. "Identification of two new genes causative of monogenic intestinal disorders Deficient function of the UNC45A-HSP90 chaperone complex impairs MYO5B expression in enterocytes and causes microvillus inclusion disease Biallelic loss-of-function mutations in IPO8 cause Loeys-Dietz-like syndrome and severe developmental defects in zebrafish." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB087.
Повний текст джерелаMy PhD thesis project is part of the efforts led by our team to dissect Mendelian diseases causing severe intestinal disorders with the scientific goal to get insight into the molecular mechanisms of the human gut barrier and with the medical goal to improve the diagnosis and care of these rare but life-threatening diseases. In the first part of my thesis, I have participated to the analysis of data generated by targeted new generation sequencing or by whole exome sequencing in order to identify known monogenic intestinal disorders and next to identify new candidate genes. In the second part of my thesis, I have led functional studies to validate mutations in two new candidate genes. On the one hand, I am analysing the mechanism of the dramatic congenital diarrheoa observed in a girl carrying an homozygous missense mutation in UNC45, a gene very recently associated with congenital diarrhoea. On the other hand, I am characterizing the functional consequences of a homozygous mutation introducing an early stop codon in IPO8 in two siblings displaying a complex syndrome including intestinal inflammation and symptoms evocative of Loeys-Dietz syndrome. Given previous indication that IPO8 may be involved in the nuclear trafficking of Smad3, we aim at demonstrating impairment of signalling downstream TGFbeta
Schlachet, Joshua Evan. "Nourishing Life: Diet, Body, and Society in Early Modern Japan." Thesis, 2018. https://doi.org/10.7916/D8NP3MZZ.
Повний текст джерелаOliveira, Filippe. "Like father, like daughter: Can maternal or early life exercise break the cycle of paternal diet-induced metabolic programming in female offspring?" Thesis, 2017. https://vuir.vu.edu.au/34721/.
Повний текст джерелаAlberto, Mónica Pinto. "Vegetarian diets in early life development: benefits, risks and unanswered questions." Master's thesis, 2021. https://hdl.handle.net/10216/134488.
Повний текст джерелаThe literature suggest that vegetarian diets decrease the burden of non-communicable diseases. However, these diets may lead to deficiency of essential nutrients which raises the concern about their adequacy during pregnancy and early life, as these are periods of great vulnerability and intense transformation and growth. The aim of this study was to revise and discuss recent literature information, about the safety and nutritional adequacy of vegetarian diets during pregnancy and childhood regarding the impact on child growth and development. For this purpose a search in Pubmed database was made for the terms:(Vegetarian diets AND fetal programing) OR (Vegetarian diets AND child development) OR (Vegetarian diets AND child growth) restricting the search between 2010 and 2020. Information on the association between vegetarian diets and nutritional deficit of vitamin B12, vitamin D, iron, zinc, calcium, iodine and omega-3 fatty acids, in early live is discussed. Plus, the association of vegetarian diets during pregnancy or childhood with fetal programming and child growth and development outcomes are discussed. Vegetarian diet seems safe for child development, if well planned. So, pregnant women and children following a vegetarian diet should seek professional advice to assess their nutritional status and avoid nutritional deficits.
Alberto, Mónica Pinto. "Vegetarian diets in early life development: benefits, risks and unanswered questions." Dissertação, 2021. https://hdl.handle.net/10216/134488.
Повний текст джерелаThe literature suggest that vegetarian diets decrease the burden of non-communicable diseases. However, these diets may lead to deficiency of essential nutrients which raises the concern about their adequacy during pregnancy and early life, as these are periods of great vulnerability and intense transformation and growth. The aim of this study was to revise and discuss recent literature information, about the safety and nutritional adequacy of vegetarian diets during pregnancy and childhood regarding the impact on child growth and development. For this purpose a search in Pubmed database was made for the terms:(Vegetarian diets AND fetal programing) OR (Vegetarian diets AND child development) OR (Vegetarian diets AND child growth) restricting the search between 2010 and 2020. Information on the association between vegetarian diets and nutritional deficit of vitamin B12, vitamin D, iron, zinc, calcium, iodine and omega-3 fatty acids, in early live is discussed. Plus, the association of vegetarian diets during pregnancy or childhood with fetal programming and child growth and development outcomes are discussed. Vegetarian diet seems safe for child development, if well planned. So, pregnant women and children following a vegetarian diet should seek professional advice to assess their nutritional status and avoid nutritional deficits.