Статті в журналах з теми "Dual inhibitors"
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Sipos, Ádám, Eszter Szennyes, Nikolett Éva Hajnal, Sándor Kun, Katalin E. Szabó, Karen Uray, László Somsák, Tibor Docsa, and Éva Bokor. "Dual-Target Compounds against Type 2 Diabetes Mellitus: Proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors." Pharmaceuticals 14, no. 4 (April 15, 2021): 364. http://dx.doi.org/10.3390/ph14040364.
Повний текст джерелаGesinski, Dayna, and Sonali Kurup. "Abstract 5337: Design, synthesis and evaluation of dual-targeted mEGFR and AURK inhibitors as anticancer agents." Cancer Research 83, no. 7_Supplement (April 4, 2023): 5337. http://dx.doi.org/10.1158/1538-7445.am2023-5337.
Повний текст джерелаKim, Min-Jeong, Sarita Pandit, and Jun-Goo Jee. "Discovery of Kinase and Carbonic Anhydrase Dual Inhibitors by Machine Learning Classification and Experiments." Pharmaceuticals 15, no. 2 (February 16, 2022): 236. http://dx.doi.org/10.3390/ph15020236.
Повний текст джерелаBošković, Jelena, Vladimir Dobričić, Marija Mihajlović, Jelena Kotur-Stevuljević, and Olivera Čudina. "Synthesis, Evaluation of Enzyme Inhibition and Redox Properties of Potential Dual COX-2 and 5-LOX Inhibitors." Pharmaceuticals 16, no. 4 (April 6, 2023): 549. http://dx.doi.org/10.3390/ph16040549.
Повний текст джерелаWang, Q. May, Robert B. Johnson, Louis N. Jungheim, Jeffrey D. Cohen, and Elcira C. Villarreal. "Dual Inhibition of Human Rhinovirus 2A and 3C Proteases by Homophthalimides." Antimicrobial Agents and Chemotherapy 42, no. 4 (April 1, 1998): 916–20. http://dx.doi.org/10.1128/aac.42.4.916.
Повний текст джерелаLu, Haiying, Lan Bai, Yanping Zhou, Yongping Lu, Zhongliang Jiang, and Jianyou Shi. "Recent Study of Dual HDAC/PARP Inhibitor for the Treatment of Tumor." Current Topics in Medicinal Chemistry 19, no. 12 (July 30, 2019): 1041–50. http://dx.doi.org/10.2174/1568026619666190603092407.
Повний текст джерелаWen, Hui, Wen Qin, Guangzhong Yang, and Yanshen Guo. "Design and Synthesis of Arylamidine Derivatives as Serotonin/Norepinephrine Dual Reuptake Inhibitors." Molecules 24, no. 3 (January 30, 2019): 497. http://dx.doi.org/10.3390/molecules24030497.
Повний текст джерелаVest, Rebekah S., Kurtis D. Davies, Heather O'Leary, J. David Port, and K. Ulrich Bayer. "Dual Mechanism of a Natural CaMKII Inhibitor." Molecular Biology of the Cell 18, no. 12 (December 2007): 5024–33. http://dx.doi.org/10.1091/mbc.e07-02-0185.
Повний текст джерелаLambert, Que T., Stuart W. Ember, Muhammad Ayaz, Harshani R. Lawrence, Norbert Berndt, Steven Gunawan, Nicholas J. Lawrence, Ernst Schönbrunn, and Gary W. Reuther. "Single Molecule Dual JAK2-BET Inhibition As an MPN Therapeutic." Blood 126, no. 23 (December 3, 2015): 2826. http://dx.doi.org/10.1182/blood.v126.23.2826.2826.
Повний текст джерелаDyer, Richard D., and David T. Connor. "Dual Inhibitors Of Prostaglandin And Leukotriene Biosynthesis." Current Pharmaceutical Design 3, no. 5 (1997): 463–72. http://dx.doi.org/10.2174/138161280305221010095741.
Повний текст джерелаOmidkhah, Negar, and Razieh Ghodsi. "NO-HDAC dual inhibitors." European Journal of Medicinal Chemistry 227 (January 2022): 113934. http://dx.doi.org/10.1016/j.ejmech.2021.113934.
Повний текст джерелаDong, Hang, Hao Yin, Chunlong Zhao, Jiangying Cao, Wenfang Xu, and Yingjie Zhang. "Design, Synthesis and Biological Evaluation of Novel Osimertinib-Based HDAC and EGFR Dual Inhibitors." Molecules 24, no. 13 (June 29, 2019): 2407. http://dx.doi.org/10.3390/molecules24132407.
Повний текст джерелаRogers, Brianne, Nicholas Rohde, Justin Mikitaroff, Joshua Matson, Samantha Satawa, Felix Amissah, and Sonali Kurup. "Abstract 5339: 4-Amino-N-phenylbenzamides as dual-targeted mEGFR and AURK inhibitors and anticancer agents." Cancer Research 83, no. 7_Supplement (April 4, 2023): 5339. http://dx.doi.org/10.1158/1538-7445.am2023-5339.
Повний текст джерелаKUMAR, Priyadarsini, and Donal A. WALSH. "A dual-specificity isoform of the protein kinase inhibitor PKI produced by alternate gene splicing." Biochemical Journal 362, no. 3 (March 8, 2002): 533–37. http://dx.doi.org/10.1042/bj3620533.
Повний текст джерелаMao, Beibei, Qi Zhang, Li Ma, Dong-Sheng Zhao, Pan Zhao, and Peizheng Yan. "Overview of Research into mTOR Inhibitors." Molecules 27, no. 16 (August 19, 2022): 5295. http://dx.doi.org/10.3390/molecules27165295.
Повний текст джерелаSun, Xuefeng, Ningning Fan, Weisi Xu, Yixing Sun, Xin Xie, Ying Guo, Liying Ma, Junyi Liu, and Xiaowei Wang. "Design, synthesis and biological evaluation of caffeoyl benzanilides as dual inhibitors of HIV integrase and CCR5." MedChemComm 7, no. 10 (2016): 2028–32. http://dx.doi.org/10.1039/c6md00311g.
Повний текст джерелаCheng, Haoyang, Yanruisheng Shao, and Yan Zhang. "Research Progress of PARP-1 Related Dual Target Inhibitors." Highlights in Science, Engineering and Technology 6 (July 27, 2022): 111–20. http://dx.doi.org/10.54097/hset.v6i.952.
Повний текст джерелаHou, Xiaodan, Honghua Yan, Xin Zhang, Weidong Qian, Dong Chen, Zhihua Ren, and Youzhi Tong. "Abstract 6509: GT0486, a novel mTORC1/2 dual inhibitor, exhibits synergistic antitumor efficacy in combination with BTK inhibitors." Cancer Research 84, no. 6_Supplement (March 22, 2024): 6509. http://dx.doi.org/10.1158/1538-7445.am2024-6509.
Повний текст джерелаWeisberg, Ellen, Lolita Banerji, Renee D. Wright, Rosemary Barrett, Arghya Ray, Daisy Moreno, Laurence Catley, et al. "Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL– and mutant FLT3-expressing cells." Blood 111, no. 7 (April 1, 2008): 3723–34. http://dx.doi.org/10.1182/blood-2007-09-114454.
Повний текст джерелаUpadhayaya, Ram S., Raghava Reddy Kethiri, Avanish Vellanki, Jeff Lightfoot, Andrea Local, and William G. Rice. "Discovery of Selective Dual Inhibitors of Bromodomain Protein BRD4 and JAK2 for Treatment of Hematologic Malignancies." Blood 128, no. 22 (December 2, 2016): 5212. http://dx.doi.org/10.1182/blood.v128.22.5212.5212.
Повний текст джерелаWong, Jacky, Robert Welschinger, Rana Baraz, Jocelyn Weiss, Ken Bradstock, and Linda J. Bendall. "Comparision of Dual PI-3K/mTOR Inhibitors with mTOR Inhibitors Using a Pre-Clinical Model of Acute Lymphoblastic Leukemia." Blood 116, no. 21 (November 19, 2010): 3258. http://dx.doi.org/10.1182/blood.v116.21.3258.3258.
Повний текст джерелаWong, Jacky, Robert Welschinger, Rana Baraz, Kenneth Francis Bradstock, and Linda J. Bendall. "Application of Dual PI-3K/mTOR Inhibitors Is Not Always Superior to Inhibition of mTOR Alone.,." Blood 118, no. 21 (November 18, 2011): 3575. http://dx.doi.org/10.1182/blood.v118.21.3575.3575.
Повний текст джерелаMin, Jian, Jerome C. Nwachukwu, Charles K. Min, Jacqline W. Njeri, Sathish Srinivasan, Erumbi S. Rangarajan, Charles C. Nettles, et al. "Dual-mechanism estrogen receptor inhibitors." Proceedings of the National Academy of Sciences 118, no. 35 (August 27, 2021): e2101657118. http://dx.doi.org/10.1073/pnas.2101657118.
Повний текст джерелаvan Gijn, R., R. R. H. Lendfers, J. H. M. Schellens, A. Bult, and J. H. Beijnen. "Dual topoisomerase I/II inhibitors." Journal of Oncology Pharmacy Practice 6, no. 3 (March 1, 2000): 92–108. http://dx.doi.org/10.1191/107815500701563317.
Повний текст джерелаKhan, Anwar A., and Guang-Wen Zeng. "Dual Action of Respiratory Inhibitors." Plant Physiology 77, no. 4 (April 1, 1985): 817–23. http://dx.doi.org/10.1104/pp.77.4.817.
Повний текст джерелаvan Gijn, R., RRH Lendfers, JHM Schellens, A. Bult, and JH Beijnen. "Dual topoisomerase I/II inhibitors." Journal of Oncology Pharmacy Practice 6, no. 3 (September 2000): 92–108. http://dx.doi.org/10.1177/107815520000600303.
Повний текст джерелаWoo, L. W. Lawrence, Christian Bubert, Oliver B. Sutcliffe, Andrew Smith, Surinder K. Chander, Mary F. Mahon, Atul Purohit, Michael J. Reed, and Barry V. L. Potter. "Dual Aromatase−Steroid Sulfatase Inhibitors." Journal of Medicinal Chemistry 50, no. 15 (July 2007): 3540–60. http://dx.doi.org/10.1021/jm061462b.
Повний текст джерелаCai, Chao-Yun, Qiu-Xu Teng, Megumi Murakami, Suresh V. Ambudkar, Zhe-Sheng Chen, and Vijaya L. Korlipara. "Design, Synthesis and Biological Evaluation of Quinazolinamine Derivatives as Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors with Improved Metabolic Stability." Biomolecules 13, no. 2 (January 30, 2023): 253. http://dx.doi.org/10.3390/biom13020253.
Повний текст джерелаKozak, Wieslaw, Inez Archuleta, Kimberly P. Mayfield, Anna Kozak, Karin Rudolph, and Matthew J. Kluger. "Inhibitors of alternative pathways of arachidonate metabolism differentially affect fever in mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 275, no. 4 (October 1, 1998): R1031—R1040. http://dx.doi.org/10.1152/ajpregu.1998.275.4.r1031.
Повний текст джерелаKurup, Sonali, Gabe Carpenter, Samantha Satawa, Felix Amissah, Erika Lisabeth, Matthew Giletto, and Edmund Ellsworth. "Abstract 4474: Novel analogs of 4-substituted pyrrolo[2,3-d]pyrimidines as dual-targeted mEGFR/AURKA inhibitors for lung cancer." Cancer Research 84, no. 6_Supplement (March 22, 2024): 4474. http://dx.doi.org/10.1158/1538-7445.am2024-4474.
Повний текст джерелаWu, Yichao, Weichen Dai, Xin Chen, Aixin Geng, Yadong Chen, Tao Lu, and Yong Zhu. "Design, synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-c]quinazoline derivatives as novel phosphatidylinositol 3-kinase and histone deacetylase dual inhibitors." RSC Advances 7, no. 82 (2017): 52180–86. http://dx.doi.org/10.1039/c7ra08835c.
Повний текст джерелаChen, Xin, Shuang Zhao, Yichao Wu, Yadong Chen, Tao Lu, and Yong Zhu. "Design, synthesis and biological evaluation of 2-amino-N-(2-aminophenyl)thiazole-5-carboxamide derivatives as novel Bcr-Abl and histone deacetylase dual inhibitors." RSC Advances 6, no. 105 (2016): 103178–84. http://dx.doi.org/10.1039/c6ra21271a.
Повний текст джерелаEstrada, Filipe G. A., Silvia Miccoli, Natália Aniceto, Alfonso T. Garcia-Sosa, and Rita C. Guedes. "Exploring EZH2-Proteasome Dual-Targeting Drug Discovery through a Computational Strategy to Fight Multiple Myeloma." Molecules 26, no. 18 (September 14, 2021): 5574. http://dx.doi.org/10.3390/molecules26185574.
Повний текст джерелаGuenther, Andreas, Renate Burger, Wolfram Klapper, Matthias Staudinger, Kathrin Richter, Tanja Ahrens, and Martin Gramatzki. "Inhibitors of Mtor and PI3K Synergistically Block Plasmacytoma Cell Growth." Blood 118, no. 21 (November 18, 2011): 2903. http://dx.doi.org/10.1182/blood.v118.21.2903.2903.
Повний текст джерелаKramer, Victor G., Susan M. Schader, Maureen Oliveira, Susan P. Colby-Germinario, Daniel A. Donahue, Diane N. Singhroy, Randy Tressler, Richard D. Sloan, and Mark A. Wainberg. "Maraviroc and Other HIV-1 Entry Inhibitors Exhibit a Class-Specific Redistribution Effect That Results in Increased Extracellular Viral Load." Antimicrobial Agents and Chemotherapy 56, no. 8 (May 21, 2012): 4154–60. http://dx.doi.org/10.1128/aac.00409-12.
Повний текст джерелаLeufven, Eva, and Øystein Bruserud. "Immunosuppression and Immunotargeted Therapy in Acute Myeloid Leukemia - The Potential Use of Checkpoint Inhibitors in Combination with Other Treatments." Current Medicinal Chemistry 26, no. 28 (October 25, 2019): 5244–61. http://dx.doi.org/10.2174/0929867326666190325095853.
Повний текст джерелаBao, Le-Quang, Daniel Baecker, Do Thi Mai Dung, Nguyen Phuong Nhung, Nguyen Thi Thuan, Phuong Linh Nguyen, Phan Thi Phuong Dung, et al. "Development of Activity Rules and Chemical Fragment Design for In Silico Discovery of AChE and BACE1 Dual Inhibitors against Alzheimer’s Disease." Molecules 28, no. 8 (April 20, 2023): 3588. http://dx.doi.org/10.3390/molecules28083588.
Повний текст джерелаSpinaci, Andrea, Michela Buccioni, Daniela Catarzi, Chang Cui, Vittoria Colotta, Diego Dal Ben, Eleonora Cescon, et al. "“Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies." Pharmaceuticals 16, no. 2 (January 23, 2023): 167. http://dx.doi.org/10.3390/ph16020167.
Повний текст джерелаZhang, Lingzhi, Qiurong Ju, Jinjin Sun, Lei Huang, Shiqi Wu, Shuping Wang, Yin Li, Zhe Guan, Qihua Zhu, and Yungen Xu. "Discovery of Novel Dual Extracellular Regulated Protein Kinases (ERK) and Phosphoinositide 3-Kinase (PI3K) Inhibitors as a Promising Strategy for Cancer Therapy." Molecules 25, no. 23 (December 3, 2020): 5693. http://dx.doi.org/10.3390/molecules25235693.
Повний текст джерелаBachmann, Luisa M., Maria Hanl, Felix Feller, Laura Sinatra, Andrea Schöler, Jens Pietzsch, Markus Laube, and Finn K. Hansen. "Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase Inhibitors." Molecules 28, no. 3 (January 20, 2023): 1061. http://dx.doi.org/10.3390/molecules28031061.
Повний текст джерелаŢînţaş, Mihaela-Liliana, Ludovic Peauger, Florent Alix, Cyril Papamicaël, Thierry Besson, Jana Sopková-de Oliveira Sopková-de Oliveira Santos, Vincent Gembus, and Vincent Levacher. "Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core." Molecules 28, no. 1 (December 21, 2022): 36. http://dx.doi.org/10.3390/molecules28010036.
Повний текст джерелаMolins, Joaquim Bellmunt, Lillian Werner, Marta Guix, Elizabeth Ann Guancial, Fabio Augusto Barros Schutz, Robert O'Brien, Edward C. Stack, et al. "PI3KCA mutations in advanced urothelial carcinoma: A potential therapeutic target?" Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 4582. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.4582.
Повний текст джерелаWoo, L. W. Lawrence, Christian Bubert, Atul Purohit, and Barry V. L. Potter. "Hybrid Dual Aromatase-Steroid Sulfatase Inhibitors with Exquisite Picomolar Inhibitory Activity." ACS Medicinal Chemistry Letters 2, no. 3 (December 29, 2010): 243–47. http://dx.doi.org/10.1021/ml100273k.
Повний текст джерелаJończyk, Jakub, Justyna Godyń, Ewelina Stawarska, Beata Morak-Młodawska, Małgorzata Jeleń, Krystian Pluta, and Barbara Malawska. "Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives—Anticancer and Cholinesterase-Inhibiting Activity." Molecules 25, no. 11 (June 3, 2020): 2604. http://dx.doi.org/10.3390/molecules25112604.
Повний текст джерелаMahnashi, Mater H., Sravanthi Avunoori, Sanjay Gopi, Ibrahim Ahmed Shaikh, Ahmed Saif, Farkad Bantun, Hani Saleh Faidah, et al. "Synthesis, molecular docking study and biological evaluation of new pyrrole scaffolds as potential antitubercular agents for dual targeting of enoyl ACP reductase and dihydrofolate reductase." PLOS ONE 19, no. 5 (May 13, 2024): e0303173. http://dx.doi.org/10.1371/journal.pone.0303173.
Повний текст джерелаKwon, Young-Ju, Dong Young Kim, Uk-Il Kim, Xue Meng, Ho Kyun Lee, Hyung Tae Bang, Jae-Sung Kim, and Kyungjin Kim. "Abstract 491: Tankyrase-selective inhibitor STP1002 reverses resistance to MEK inhibitors in colorectal cancer with KRAS mutations." Cancer Research 83, no. 7_Supplement (April 4, 2023): 491. http://dx.doi.org/10.1158/1538-7445.am2023-491.
Повний текст джерелаAl-Wahaibi, Lamya H., Hesham A. Abou-Zied, Mohamed Hisham, Eman A. M. Beshr, Bahaa G. M. Youssif, Stefan Bräse, Alaa M. Hayallah, and Mohamed Abdel-Aziz. "Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAFV600E Inhibitory Pathways." Molecules 28, no. 18 (September 12, 2023): 6586. http://dx.doi.org/10.3390/molecules28186586.
Повний текст джерелаTanabe, Kenji. "Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors." International Journal of Molecular Sciences 18, no. 12 (November 23, 2017): 2508. http://dx.doi.org/10.3390/ijms18122508.
Повний текст джерелаTabrizchi, Reza. "Dual ACE and Neutral Endopeptidase Inhibitors." Drugs 63, no. 20 (2003): 2185–202. http://dx.doi.org/10.2165/00003495-200363200-00003.
Повний текст джерелаOmidkhah, Negar, Farzin Hadizadeh, and Razieh Ghodsi. "Dual HDAC/BRD4 inhibitors against cancer." Medicinal Chemistry Research 30, no. 10 (August 14, 2021): 1822–36. http://dx.doi.org/10.1007/s00044-021-02776-9.
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