Дисертації з теми "Drug nanoparticles"
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Sepassi-Ashtiani, Shadi. "Polymer-stabilised drug nanoparticles." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406852.
Повний текст джерелаTirop, Lucy. "Polymer-surfactant stabilised drug nanoparticles." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/polymersurfactant-stabilised-drug-nanoparticles(46bd0161-25d6-4337-ba65-f9fe3627e804).html.
Повний текст джерелаFallon, Marissa S. "Drug overdose treatment by nanoparticles." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0013055.
Повний текст джерелаQin, Jian. "Nanoparticles for multifunctional drug delivery systems." Licentiate thesis, Stockholm : Kemi, Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4369.
Повний текст джерелаSong, Wenxing. "Magnetic nanoparticles for drug/gene delivery." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/22310/.
Повний текст джерелаCzapar, Anna. "Virus-Based Nanoparticles Cancer Drug Delivery." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1499438915195222.
Повний текст джерелаRedhead, Helen Margaret. "Drug loading of biodegradable nanoparticles for site specific drug delivery." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338495.
Повний текст джерелаComenge, Farre Joan. "Gold Nanoparticles as Drug Delivery Agents. Detoxifying the Chemotherapeutic Drug Cisplatin." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/125963.
Повний текст джерелаThe use of nanoparticles (NPs) has emerged as a potential tool to improve cancer treatment. Among the proposed uses in imaging and therapy, their use as a drug delivery scaffold has been extensively highlighted. However, there are still some controversial points which need a deeper understanding before applying them in the clinics. Here, it is presented the use of gold nanoparticles (AuNPs) to detoxify the antitumoral agent cisplatin linked to the nanoparticle via a pH sensitive coordination bond for endosomal release. Since size of NPs plays an important role in determining biological responses such as biodistribution or clearance by immune system, a perfect control on the synthesis of AuNPs is required previously to any biological application of these AuNPs. It is described in this work a new synthetic protocol of biocompatible AuNPs with a perfect control of the size between 5 to 200 nm. One of the advantages of this protocol is the obtaining of citrate-capped AuNPs that can be further functionalized. This allowed us to provide insights on the mechanism of Self-Assembled Monolayers and mixed layers formation. The control of the mixed layer composition and conformation is important since it determines biological outcomes such as protein adsorption and colloidal stability in physiological media. These AuNPs conjugates are used as scaffold for cisplatin attachment via the formation of a coordination bond that ensures a pH-triggered release of the drug. This conjugation is deeply characterized to ensure the maintenance of colloidal and link stability on working conditions. Finally, the NP conjugate design has important effects on pharmacokinetics, conjugate evolution and biodistribution and absence of observed toxicity. Here we show that cisplatin-induced toxicity is clearly reduced without affecting the therapeutic benefits in mice models. The NPs not only act as carriers, but also protect the drug from deactivation by plasma proteins until conjugates are internalised in cells and cisplatin released. Also, the possibility to track the drug (Pt) and the vehicle (Au) separately as a function of organ and time enables a better understanding of how nanocarriers are processed by the organism.
Chiewpattanakul, Paramaporn. "Isolation and structure elucidation of biosurfactant from microorganism and its application model in drug delivery system." Thesis, Vandoeuvre-les-Nancy, INPL, 2010. http://www.theses.fr/2010INPL004N/document.
Повний текст джерелаBiosurfactant producing microorganisms were isolated from oil contaminated soils collected from Songkhla and Chiangmai province, Thailand and Shianghai, China. Their culture broths were screened for obtaining biosurfactants with the highest surface activity and emulsification ability. Among 102 isolates, 6 microorganisms produced biosurfactants. The culture supernatant of SK80 strain exhibited the highest surface activity. SK80 was identified by macroscopic morphology, microscopic morphology and showed that it is a black mold. The 28S rRNA sequence homology analysis suggested that SK80 belongs to Exophiala dermatitidis. The composition of culture medium such as carbon source, nitrogen source, and culture condition of this microorganism was optimized to obtain high amounts of biosurfactant. 1H NMR, 13C NMR, COSY and Mass Spectrometer (APCI MS) results indicated that this biosurfactant was monoolein (oleoyl glycerol), a kind of monoacylglycerol. Monomyristin was chosen as a monoacylglycerol model to be synthesized and used as nanoparticle encapsulated drug. Two preparation methods, emulsion/solvent evaporation and nanoprecipitation, were used to encapsulate monomyristin in dextran-covered nanoparticles with poly(lactic acid) of hydrophobized dextran as the core material. Encapsulation conditions were optimized with regard to the yield encapsulation and the colloidal stability
Cleroux, Carolyne. "Biodegradable nanoparticles for sustained occular drug delivery." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28485.
Повний текст джерелаWeiß, Veronika Ortrud Sophie. "Mesoporous silica nanoparticles as drug delivery platforms." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-185595.
Повний текст джерелаTriplett, Michael David. "Enabling solid lipid nanoparticle drug delivery technology by investigating improved production techniques." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1101830018.
Повний текст джерелаTitle from first page of PDF file. Document formatted into pages; contains xv, 172 p.; also includes graphics (some col.). Includes bibliographical references (p. 161-172).
Kumar, Dhiraj. "Co-Functionalised Gold Nanoparticles for Drug Delivery Applications." Thesis, Ulster University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.649271.
Повний текст джерелаKoh, Chee Guan. "Microfluidic Assembly Of Nanoparticles For Gene/Drug Delivery." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1218638305.
Повний текст джерелаSengupta, Aritra. "Intracellular drug delivery using laser activated carbon nanoparticles." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53996.
Повний текст джерелаRodzinski, Alexandra. "Targeted and Controlled Anticancer Drug Delivery and Release with Magnetoelectric Nanoparticles." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2976.
Повний текст джерелаBasu, Sarkar Arindam Kochak Gregory Michael. "Carbohydrate nanoparticles a novel drug delivery platform for the systemic route /." Auburn, Ala., 2006. http://repo.lib.auburn.edu/2006%20Summer/Dissertations/BASU_SARKAR_26.pdf.
Повний текст джерелаOh, Sejin. "Development of mucus permeating nanoparticles-based drug delivery systems." Doctoral thesis, Universitat Ramon Llull, 2016. http://hdl.handle.net/10803/382626.
Повний текст джерелаExiste un interés creciente, tanto en el mundo académico como en la investigación industrial en el desarrollo de sistemas de liberación de fármacos macromoleculares (proteínas, péptidos, oligonucleótidos) capaces de atravesar la mucosa. En este sentido, la utilización de vectores sintéticos para la liberación de dichas macromoléculas, permite disponer de una plataforma versátil y altamente eficiente. Sin embargo, la capa de mucosa con propiedades adhesivas y altamente viscoelástica, tiene una elevada capacidad de atrapar y eliminar cualquier sustancia extraña que quede adherida sobre su superficie, limitando, de forma evidente, la eficacia de cualquier tratamiento Esta Tesis se centra en el desarrollo de sistemas de liberación de ADN, diseñados a medida, que presentan una elevada estabilidad y eficacia de transfección con un nivel muy bajo de toxicidad y muy importante en el contexto de la tesis, una capacidad de permeación a través de la mucosa. Además la tesis también se centra en el diseño y el desarrollo de métodos y técnicas in vitro que ayuden a una mejor selección de sistemas eficientes de liberación a través de la mucosa. Así se ha desarrollado un método simple y eficiente, basado en la utilización de una microbalanza de cuarzo con disipación (QCM-D). Este método ha permitido evaluar la interacción de polímeros y nanopartículas con una capa de mucina. Los resultados obtenidos con el método desarrollado han permitido diseñar sistemas de nanopartículas con un mayor potencial de permeación a través de la mucosa. Esta técnica de alta sensibilidad también ha ofrecido la posibilidad de evaluar las dos propiedades opuestas, el conocimiento de las cuales es necesario para un correcto diseño de sistemas cpaços de cruzar la mucosa: mucoadhesió vs mucopenetració. Los Poly (β-amino ester)s (PBAEs) se han propuesto como sistemas biodegradables capaces de formar nanopartículas, por complejación con ADN, que presentan una elevada capacidad de transfección. Sin embargo, muestran problemas de estabilidad en condiciones fisiológicas y son incapaces de atravesar la capa de mucosa. En esta tesis se describe una nueva solución en la preparación de las formulaciones de los nanocomplejos basada en la utilización de recubrimientos que estabilizan las nanopartículas y aumentan su permeabilidad. Los recubrimeintos propuestos inclutyen: i) azúcares (sucrosa, trhalosa y manitol), ii) quitosano sin modificar de 22 KDa y con 60-120 kDa, iii) quitosano modificado con ácido tioglicólico y iv) ácido poliacrílico-bromelaina. Todas las nuevas formulaciones se han evaluado con diferentes cantidades de recubrimiento. Se han determinado sus propiedades fisicoquímicas y su eficacia de transfección y citotoxicidad frente a células COS-7. Se ha estudiado La difusión de las partículas a través de la mucosa gástrica de cerdo utilizando diferentes técnicas como el tubo rotatorio de silicona o el múltiple particle tracking (MPT). Los resultados obtenidos han mostrado superior estabilidad, eficacia de transfección y permeabilidad sobre la mucosa de las nuevas formulaciones diseñadas.
Mucus penetrating nanoparticle-based delivery systems of macromolecular drugs are currently receiving increasing attention in both academic and industrial research. Synthetic delivery systems provide highly suitable and tunable platform for the delivery of the macromolecules. However, a highly viscoelastic and adhesive mucus layer generally traps and rapidly removes most foreign substance from the mucosal surfaces, thereby limiting effectiveness of these nanocarriers. This Thesis is addressed to the development of engineering DNA delivery systems capable of high stability and transfection efficiency with low toxicity, and quickly crossing the mucus layer. Moreover, this Thesis is focused on design and development of methods and techniques in vitro in order to select more efficient delivery systems. A simple and efficient method, based on the use of the quartz crystal microbalance with dissipation (QCM-D) technique, is developed and evaluated the interaction of the polymers and nanoparticles with the mucin layer, resulting in the development of nanoparticle-based delivery systems to mucosal tissue. This highly sensitive technique also offers to evaluate the two opposing properties, needed for the design of efficient mucous permeation systems: mucoadhesion vs mucus penetration. Poly(β-amino ester)s (PBAEs) are currently considered of great interest as biodegradable polymeric carriers of DNA delivery, but they present limited stability in physiological conditions and the inability to penetrate the mucus layer. In this Thesis, we describe a novel surface-modified formulation of DNA delivery systems consisting of PBAE/DNA complexes and the coating agents, including: i) sugars (sucrose, trehalose or mannitol), ii) unmodified chitosan with a 22 kDa (CS) and a with a 60-120 kDa (CSM), iii) chitosan-thioglycolic acid (CS-TGA), and iv) poly(acrylic acid)-bromelain (PAA-BRO) conjugates. All novel formulations formed with different amounts of the coating agents are evaluated the physicochemical properties. The influence of coating agents on transfection efficiency and cytotoxicity is evaluated in COS-7 cells. Particle diffusion through porcine intestinal mucus (PImucus) is assessed by either rotating silicone tube technique or multiple particle tracking (MPT). The results highlight the superior stability, transfection efficiency and mucus permeability of the novel nanoparticle-based drug delivery systems. The effect of the amount of coating agents is also discussed.
Martínez, Edo Gabriel. "Radial-capped mesoporous silica nanoparticles for multiple drug delivery." Doctoral thesis, Universitat Ramon Llull, 2020. http://hdl.handle.net/10803/669168.
Повний текст джерелаEn la presente tesis doctoral, se ha desarrollado un sistema de liberación de fármacos sensible a pH basado en nanopartículas mesoporosas de sílice (MSN). Los poros de la nanopartícula están radialmente obstruidos mediante la funcionalización de cadenas de PEG, sustituidas con un fármaco en uno de sus extremos. El objetivo de esta nueva metodología es la de preservar la carga interna de estas MSN. En primer lugar, se ha estudiado el concepto de obstrucción radial para evaluar la utilidad práctica de este método. Por esta razón, diferentes tipos de cadenas de PEG con carga, a saber, aminas cuaternarias y PEG neutrales, se han funcionalizado sobre la MSN para estudiar su capacidad de obstrucción. Como prueba de concepto, se ha estudiado la liberación de safranina en medio fisiológico (pH 7.4). Los resultados obtenidos han demostrado que las cadenas de PEG que contienen una carga positiva obstruyen mejor los poros que las cadenas de PEG neutrales de la misma longitud. Utilizando esta aproximación, se ha diseñado un sistema de liberación de fármacos para la vehiculización de camptotecina (CPT) y topotecán (TPT). En primer lugar, uno de los anteriores fármacos se ha adsorbido dentro de los poros de la MSN. Posteriormente, los poros se han sellado mediante una cadena de PEG que contiene doxorrubicina (DOX) en uno de sus extremos (DOX-PEG). La estabilidad de dicho sistema en condiciones fisiológicas prueba la eficacia de la obstrucción radial. Por otro lado, en condiciones ácidas, se produce una liberación descontrolada de los fármacos. Asimismo, los experimentos de citotoxicidad in vitro han demostrado que el sistema puede liberar CPT y DOX en las células cancerígenas HeLa, logrando un mayor efecto sinérgico que la combinación de TPT y DOX. También se ha sintetizado un profármaco de la CPT con el objetivo de aumentar su carga en una MSN y mejorar así su efecto sinérgico con la DOX. Para llevarlo a cabo, se ha unido una cadena escindible de PEG a la CPT. Empleando esta estrategia se ha conseguido cargar un 30% más de CPT en el interior de las MSN. El sistema muestra una gran estabilidad en condiciones fisiológicas, ya que se observa una liberación negligible de los fármacos. Además, se ha evaluado la citotoxicidad del sistema en dos líneas celulares diferentes: HeLa y HepG2. Los resultados obtenidos demuestran que el nuevo profármaco sintetizado en combinación con DOX, resulta en un mayor efecto sinérgico en las células HepG2. Por otro lado, la selectividad de las MSN hacia las células HepG2 se ha mejorado mediante la introducción del ligando ácido glicirretínico (GA) sobre el grupo DOX-PEG. Para llevarlo a cabo, se ha empleado la misma aproximación radial establecida para los otros sistemas. Los estudios de internalización celular han demostrado que este nuevo sistema es capaz de discriminar entre las células HeLa y HepG2, acumulándose preferentemente en estas últimas. Finalmente, se ha evaluado un sistema de administración triple de medicamentos con el objetivo de superar el efecto de resistencia de los tumores a múltiples fármacos. Esta acción se puede emprender mediante la combinación de medicamentos quimioterapéuticos, DOX y CPT, con un agente fototerapéutico (ftalocianina). Por esta razón, se ha sintetizado un nuevo conjugado de la CPT con una ftalocianina. Dicho conjugado se ha cargado dentro de los poros de la MSN y posteriormente se han sellado con el grupo DOX-PEG. Los experimentos de internalización celular han demostrado la endocitosis de este sistema en las células HeLa y la posterior liberación de los fármacos. Asimismo, se ha evaluado in vitro el efecto sinérgico entre la DOX y la CPT.
In this PhD dissertation, a pH-responsive multiple drug delivery system (DDS) based on mesoporous silica nanoparticles (MSN) with a radial-capping of its pores has been developed. This is a new concept that relies on the functionalization of the particle surface with PEG chains substituted with a drug at its end to preserve the inner cargo of the MSN. First, the concept of radial-capping has been studied to assess the practical usefulness of such capping method. Thus, different types of charged PEGs, namely quaternary amines and neutral PEGs, have been introduced upon an MSN in order to study its capping ability. As a proof of concept, the dye safranin was loaded into the nanoparticles pores, which were subsequently capped with PEGs chains. Then, the release of safranin was assessed under physiological conditions (pH 7.4). The results obtained demonstrated that PEG chains possessing positive charge provides a more efficient capping than the neutral PEGs of the same length. Using this approach, a drug delivery system (DDS) based on the radial capping for the delivery of camptothecin (CPT) and topotecan (TPT) has been studied. CPT or TPT has been loaded within the pores of an MSN, and subsequently sealed with a PEG chain decorated with doxorubicin (DOX) at its end (DOX-PEG moiety). The system is stable under physiological conditions (pH 7.4) which confirms the effectiveness of the radial capping. On the other hand, under acidic pH, a burst release of drugs takes place. Furthermore, the in vitro cytotoxicity test has demonstrated that this DDS can effectively deliver CPT and DOX to HeLa cells achieving a better synergistic effect than the combination of TPT and DOX. With the aim to improve the loading of CPT to enhance the synergistic effect with the latter system (DOX-PEG moiety), a prodrug of CPT has been synthesised. To do so, a cleavable reductive short PEG chain has been bonded to CPT. An increase of loading of 30% has been achieved in comparison with the unmodified drug. The stability of the radial-capping methodology has been tested as mentioned above. Under physiological conditions, the release of drugs is negligible. The cytotoxicity activity of the system has been tested in two different cell lines: HeLa and HepG2 cells. The results showed a better synergistic effect of this new synthesised system towards HepG2 cells. In order to further improve the selectivity of the system towards HepG2 cells, the MSN were decorated with glycyrrhetinic acid (GA) ligand over the DOX-PEG moiety. Uptake studies have shown that this new system preferably accumulates in HepG2 cells in comparison to HeLa cells. Finally, a tri-deliver system of drugs has been developed with the aim to try to overcome the multiple drug-resistant (MDR) effect by the combination of chemotherapeutic drugs (DOX and CPT) with a phototherapeutic agent (phthalocyanine). In this regard, a new CPT conjugate with a phthalocyanine has been synthesised and loaded within the pores of an MSN. Then, the system has been sealed with the DOX-PEG moiety. The uptake studies have demonstrated the proper endocytosis of the system inside HeLa cells and the subsequent delivery of the three drugs in the cytoplasm and nucleus. Furthermore, the synergistic effect of DOX and CPT has been assessed in vitro.
Smith, Michael Hughes. "The design of multifunctional hydrogel nanoparticles for drug delivery." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/43609.
Повний текст джерелаFuchs, Sebastian. "Gelatin Nanoparticles as a modern platform for drug delivery." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-136924.
Повний текст джерелаMarouf, W. M. Y. "Design and characterisation of targeting drug-loaded polymeric nanoparticles." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484986.
Повний текст джерелаIbegbu, Madu Daniel. "Functionalised dextran nanoparticles for drug delivery to the brain." Thesis, University of Portsmouth, 2015. https://researchportal.port.ac.uk/portal/en/theses/functionalised-dextran-nanoparticles-for-drug-delivery-to-the-brain(c2da4093-315e-4647-90e1-4340acf2b8bd).html.
Повний текст джерелаFay, François. "Development of versatile drug delivery strategies using PLGA nanoparticles." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527933.
Повний текст джерелаTidbury, Louise. "Development and biological assessment of prednisolone solid drug nanoparticles." Thesis, University of Liverpool, 2018. http://livrepository.liverpool.ac.uk/3016766/.
Повний текст джерелаHu, Yuhua Ph D. Massachusetts Institute of Technology. "pH-sensitive core-shell nanoparticles for intracellular drug delivery." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/42942.
Повний текст джерелаThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Vita.
Includes bibliographical references (p. 193-208).
Therapeutics such as proteins, DNA, or siRNA, can only exert their function in the cell cytosol or nucleus. However, most of them are cell membrane impermeable molecules that can only be taken up by cells via endocytosis or phagocytosis. Such drug molecules are thus confined in endolysosomes, where reduced pH and degradative enzymes may destroy them without therapeutic gain. Efficient escape of drug molecules to the cytosol before destruction in endolysosomes is a major challenge for intracellular drug delivery. To address this issue, we designed a pH-sensitive core-shell nanoparticle to segregate the functions of the particle into an endosome-disrupting pH-responsive core that would absorb protons at endolysosomal pH, and a shell whose composition could be tuned to facilitate particle targeting, cell binding, and drug binding. Two-stage surfactant-free emulsion polymerization of 2-diethylamino ethyl methacrylate (DEAEMA) (core) and 2-amino ethyl methacrylate (AEMA) (shell) in the presence of a crosslinker was used for the synthesis of monodisperse core-shell hydrogel nanoparticles of 200 nm in diameter. The protonation of tertiary amine groups on the polyDEAEMA core on moving from extracellular to endolysosomal pH resulted in reversible swelling of the nanoparticles with a 2.8-fold diameter change. With the aid of pH-sensitivity of these nanoparticles, efficient cytosolic delivery of calcein (with ~95% efficiency) was achieved by disrupting endolysosomes via proton sponge effect. The primary amine rich shell was found to facilitate cell and drug binding, and provided negligible cytotoxicity by sequestering the proton sponge component from any direct interactions with cells. These particles demonstrated a useful means to deliver therapeutic molecules to the cytosol of cells of interest efficiently.
(cont.) The applications of nanoparticles showed significant improvement in delivering a model antigen vaccine protein ovalbumin (OVA) to primary dendritic cells for T cell activation, and promising knockdown of mRNA by delivering siRNA to epithelial cells for gene silencing. To extend this approach to a fully biodegradable system, nanoparticles with a cleavable crosslinker bis (acryloyl) cystamine (BAC) were synthesized. Preliminary explorations of this approach showed that such particles can degrade in the presence of glutathione in vitro, a reducing peptide present at mM concentrations in the cytosol of mammalian cells. This design could potentially serve as a drug releasing mechanism to further improve delivery efficiency.
by Yuhua Hu.
Ph.D.
Kyriazi, Maria Eleni. "DNA-coated gold nanoparticles for sensing and drug delivery." Thesis, University of Southampton, 2018. https://eprints.soton.ac.uk/423464/.
Повний текст джерелаLi, Jie. "Polymeric Nanoparticles for Ultrasonic Enhancement and Targeted Drug Delivery." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1280349038.
Повний текст джерелаZhang, Mengzi. "DEVELOPMENTS OF LIPID-BASED NANOPARTICLES FOR THERAPEUTIC DRUG DELIVERY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417025932.
Повний текст джерелаFox, Tara L. "Characterizing Environmentally Responsive Polymer-Based Nanoparticles for Drug Delivery." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459341789.
Повний текст джерелаChen, Li. "Development and characterization of controlled drug delivery using nanoparticles." ScholarWorks@UNO, 2004. http://louisdl.louislibraries.org/u?/NOD,161.
Повний текст джерелаTitle from electronic submission form. "A thesis ... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Chemistry."--Thesis t.p. Vita. Includes bibliographical references.
Vivero-Escoto, Juan Luis. "Surface functionalized mesoporous silica nanoparticles for intracellular drug delivery." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3389157.
Повний текст джерелаVellore, Janarthanan Mohanraj. "Formulation of chitosan-based nanoparticles for delivery of proteins and peptides." Thesis, Curtin University, 2003. http://hdl.handle.net/20.500.11937/1224.
Повний текст джерелаSun, Yanqi. "Studies of PLGA Nanoparticles for Pharmaceutical Applications." Thesis, Cranfield University, 2014. http://dspace.lib.cranfield.ac.uk/handle/1826/9232.
Повний текст джерелаMazumder, Sonal. "Synthesis and Characterization of Drug-Containing, Polysaccharide-Based Nanoparticles for Applications in Oral Drug Delivery." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/23692.
Повний текст джерелаThe purpose of this research was two-fold. First, the methodology for producing drug-polymer nanoparticles with well-defined particle size distributions was developed. Second, the factors affecting drug loading and release properties of these nanoparticles were investigated. The nanoparticles were processed using two methods of solvent removal and drying to investigate their effects on drug loading and particle size: (a) various combinations of rotary vacuum evaporation (rotavap) and acid-induced flocculation were used and (b), dialysis followed by freeze drying. Dynamic light scattering showed particle sizes were between 150-400 nm with polydispersity index values as low as 0.12. The antibiotic drug loading efficiencies ranged from 14-40%, whereas drug loading efficiency as high as 85 % was attained with the antiviral drug. The dissolution studies showed an increase in the solution concentration and release of the amorphous drug nanoparticles. The high glass transition temperature helped to stabilize the drug in an amorphous form, thus increasing the effective solution concentration of the drug in an aqueous medium.
Ph. D.
Vinciguerra, Daniele. "Drug-initiated synthesis and biological evaluation of heterotelechelic polymer prodrug nanoparticles." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS592.
Повний текст джерелаA facile and versatile synthetic platform to prepare high drug loading, heterobifunctional polymer prodrug nanoparticles was developed by combining the “drug-initiated” method to obtain α-functional polymer prodrugs by nitroxide-mediated polymerization (NMP), and the nitroxide exchange reaction from a functional nitroxide to attach a second molecule of interest at the ω chain-end. A library of heterotelechelic polymers prodrugs with different combinations for various purposes (e.g., drug delivery, imaging/theranostic, combination therapy, active targeting) was prepared using polyisoprene (PI) as polymer scaffold. More specifically, an alkoxyamine based on the SG1 nitroxide was functionalized with the first drug of interest and used to perform the NMP of isoprene to yield the desired polymer prodrug. Subsequently, by applying the nitroxide exchange reaction using a TEMPO nitroxide functionalized with the second molecule of interest, the SG1 nitroxide at the chain-end was quantitatively replaced by the functional TEMPO and the desired heterobifunctional polymer prodrug was formed. This general methodology was applied to the following combinations: (i) gemcitabine (Gem)/rhodamine (Rho) and Gem/cyanine for drug delivery and imaging; (ii) aminoglutethimide (Agm)/doxorubicin (Dox), Gem/Dox and Gem/Lapatinib (Lap) for combination therapy and (iii) Gem/biotin for drug delivery and active targeting in vitro and in vivo. For polymer prodrug nanoparticles bearing fluorescent dyes, in vitro and in vivo imaging studies were performed to investigate their cellular internalization and their biodistribution, respectively. As for the different combination therapies, the in vitro cytotoxicity of the nanoparticles was determined and compared to that of other strategies to deliver two different drugs (e.g., conanoprecipitation, physical mixture of nanoparticles).Finally, heterobifunctional polymer prodrugs bearing adenosine in alfa position and a maleimide moiety in omega position were synthesized to give nanoparticles that were further surface-functionalized with different proteins able to promote crossing through the blood brain barrier for drug delivery to the brain
Gengler, Malou. "Reductively degradable poly(ethylene glycol) nanoparticles for intracellular drug delivery /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17501.
Повний текст джерелаSauer, Anna Magdalena. "Live-cell imaging of drug delivery by mesoporous silica nanoparticles." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-138222.
Повний текст джерелаBin, Bostanudin Mohammad Fauzi. "Butylglyceryl-modified polysaccharide nanoparticles for drug delivery to the brain." Thesis, University of Portsmouth, 2016. https://researchportal.port.ac.uk/portal/en/theses/butylglycerylmodified-polysaccharide-nanoparticles-for-drug-delivery-to-the-brain(a91de9ba-3070-40a4-bf66-400f4d63027d).html.
Повний текст джерелаFach, Lars Matthias [Verfasser]. "Protein-based nanoparticles for drug delivery applications / Lars Matthias Fach." Mainz : Universitätsbibliothek Mainz, 2018. http://d-nb.info/116056146X/34.
Повний текст джерелаPorsch, Christian. "Exploring Amphiphilic PEGMA-Based Architectures as Nanoparticles for Drug Delivery." Doctoral thesis, KTH, Ytbehandlingsteknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-173242.
Повний текст джерелаQC 20150909
Armstrong, Trevor Ian. "Protein adsorption onto polymeric nanoparticles : its relevance to drug targeting." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284047.
Повний текст джерелаBABANYINAH, GODWIN KWEKU. "Theranostic Nanoparticles Folic acid-Carbon Dots-Drug(s) for Cancer." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/40.
Повний текст джерелаBabanyinah, Godwin Kweku. "Theranostic Nanoparticles Folic Acid-Carbon Dots-Drug(s) for Cancer." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/etd/3892.
Повний текст джерелаLundberg, Sara, Emelia Karlsson, Hugo Dahlberg, Mathilda Glansk, Sara Larsson, Sofia Larsson, and Karl Carlsson. "Exosomes and lipid nanoparticles - the future of targeted drug delivery." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-411993.
Повний текст джерелаSlater, Rebecca. "Novel amphiphilic branched copolymer nanoparticles as candidates for drug delivery." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/16215/.
Повний текст джерелаSteiert, Elena [Verfasser]. "Dynamic Protein-based Nanoparticles for Drug Delivery Applications / Elena Steiert." Mainz : Universitätsbibliothek Mainz, 2020. http://d-nb.info/1205821899/34.
Повний текст джерелаChow, Gan-Moog. "Nanoparticles for Targeted Drug Delivery." 2003. http://hdl.handle.net/1721.1/3936.
Повний текст джерелаSingapore-MIT Alliance (SMA)
Solfiell, David J. "Gold Nanoparticles and Drug Delivery." 2014. https://scholarworks.umass.edu/theses/1200.
Повний текст джерелаFerreira, Francisco Ribeiro. "Chitosan Nanoparticles as Drug Delivery Systems." Master's thesis, 2015. http://hdl.handle.net/10362/56812.
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