Дисертації з теми "Drug delivery matrices"
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Feely, L. C. "Controlled release hydroxypropylmethylcellulose mini-matrices." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373348.
Wang, Yiwei. "Improving 3D matrices for tissue engineering using advanced drug delivery techniques." Thesis, Kingston University, 2007. http://eprints.kingston.ac.uk/20391/.
Pywell, E. J. "Studies on some polymeric matrices for use in transdermal drug delivery systems." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378309.
Caldwell, Deborah Leigh. "Characterisation of drug loaded insoluble polymeric matrices prepared by hot melt extrusion technology for drug delivery applications." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579769.
Kuduğ, Emre Batıgün Ayşegül. "Use Of Fibroin/Hyaluronic Acid Matrices As A Drug Reservoir In Iontophoretic Transdermal Delivery/." [s.l.]: [s.n.], 2004. http://library.iyte.edu.tr/tezler/master/kimyamuh/T000297.pdf.
Melocchi, A. "INJECTION MOLDING/MICROMOLDING APPLICATIONS TO DRUG DELIVERY." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/251825.
Liu, Haoyu. "Synthesis and Structure-property Evaluation of Novel Cellulosic Polymers as Amorphous Solid Dispersion Matrices for Enhanced Oral Drug Delivery." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/54934.
Ph. D.
FEDERICO, Salvatore. "Advanced electrospun matrices based on polysaccharide derivatives for applications in regenerative medicine." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/521949.
Wang, Qing. "STRATEGIES FOR SUSTAINED RELEASE OF SMALL HYDROPHILIC DRUGS FROM HYDROGEL BASED MATRICES." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1515164088562922.
Batista, Jorge Gabriel dos Santos. "Desenvolvimento de matrizes poliméricas biodegradáveis à base de quitosana e possíveis blendas como sistemas de liberação controlada de fármacos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-18022016-145449/.
According to the concept of drug delivery systems, this study has based on the use of biocompatible hydrophilic polymers hydrogels-forming for the development of matrices in the form of thin films. The polymers used for forming the matrices were chitosan from shrimp shells, modified maize starch and poly(N-vinyl-2-pyrrolidone) PVP. The matrices were cross-linked using glutaraldehyde. The drug chosen to test the ability of the devices release was the non-steroidal anti-inflammatory drug (NSAID) sodium diclofenac. Mixtures between chitosan-starch and chitosan-PVP tested to obtain the matrices with suitable properties for this purpose. The devices after qualitative screening had evaluated for cytotoxicity, maximum swelling, gel fraction, kinetic parameters associated with absorbing water vapor and the release of diclofenac sodium able to in vitro. The formulations based on chitosan-PVP were the presents the best properties, in evidence formulation A3, with high percentage of delivery, good handing properties, few compounds/components reducing the allergenic potential and successful in vitro cell viability red uptake cytotoxicity assay, using cell culture mouse cells (NCTC).
Li, Bin. "Molecularly imprinted polymers for applications in cosmetology." Thesis, Compiègne, 2013. http://www.theses.fr/2013COMP2083.
Molecularly imprinted polymers (MIPs) are tailor-made synthetic receptors possessing specific cavities for a given target molecule. They are produced by introducing, into the polymer precursors, guest molecules that act as templates at the molecular level. Interacting and cross-linking monomers are then copolymerized to form a cast-like shell. After removal of the template, cavities complementary to the template in size, shape and position of functional groups are revealed in the polymer, which can now specifically bind the template. Thanks to these specific molecular recognition properties, MIPs have found applications in areas like bio sensors, solid phase extraction, affinity chromatography, catalysis, and drug delivery. Although the MIP concept originated from imprinted silica in the 1930s, imprinted sol-gel materials received little attention afterwards due to the introduction of the more versatile organic polymers as imprinting matrix. However, compared to organic polymers, sol-gels possess higher thermal stability, better water compatibility and larger inner surface area. There have been many applications to biomolecules in aqueous conditions with sol-gel imprinting materials. In this thesis, we have developed organic and silica sol-gel MIPs for applications in cosmetics and drug delivery. MIPs able to adsorb the dandruff-inducing molecule oleic acid (OA) were produced via both the organic and inorganic routes. In the organic MIPs synthesis, different positively charged monomers were used, one of which, acryloyl aminobenzamidine, was specifically synthesized. Although some binding of oleic acid was obtained, specificity and capacity of these polymers were not satisfying. Sol-gel MIPs, on the other hand, exhibited good specific recognition and high binding capacity for OA. A MIP of the composition OA:APTES:TEOS= 1:1.6:1.7 yielded a capacity of 625 μmol.g-1 in artificial sebum. Furthermore, tests were carried out to capture OA on stratum corneum and reconstructed skin (Episkin). Less penetration of OA was observed in the presence of a MIP than with a non-imprinted control polymer. Deodorant materials are another topic of this thesis. MIPs that are able to adsorb certain precursors of odorant molecules, the glutamine conjugates of (E)-3-methyl-2-hexenoic acid (3M2H) and 3-hydroxy-3-methyl-hexanoic acid (3H3MH) were prepared. N-hexanoyl glutamine and N-hexanoyl glutamate were used as templates. After optimization of the MIP composition, we found that MIPs synthesized with acryloyl aminobenzamidine as functional monomer had the highest adsorption capacity for N-hexanoyl glutamine, and also recognised the glutamine targets of 3M2H and 3H3MH. Some preliminary promising binding results were obtained in artificial sweat. The third part of this work concerns a drug delivery MIP. Salicylic acid (SA) is a drug used to treat acne. SA-imprinted polymers were prepared via both organic imprinting and the sol-gel process.Compared to organic MIPs, sol-gel MIPs have a higher capacity, 180 μmol.g-1, and 7 times higher binding than to a non-imprinted control polymer was observed. Release tests were carried out in different aqueous media, the most efficient drug release was observed in pure water. In conclusion, applications of molecularly imprinted polymers for cosmetics and drug delivery have been investigated. Our results demonstrate the great potential of in particular sol-gel MIPs for these purposes
Loth, Capucine. "Exploring hydrogels based on the self-assembly of a Fmoc-based tripeptide : physicochemical characterization and antibacterial properties." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAE002.
Hydrogels are 3D networks of fibers that retain large amounts of water when swollen. Due to their biocompatibility, they are increasingly used for drug delivery. To develop antibacterial peptide-based hydrogels, this dissertation presents two studies based on the use of a fluorenylmethoxycarbonyl (Fmoc)-protected phosphorylated tripeptide that can self-assemble into a hydrogel. In the first study, different preparation conditions (pH, salt, presence of polysaccharide) were investigated to obtain a self-healing and antibacterial hydrogel capable of releasing an antibiotic, florfenicol. In the second study, a solid-phase peptide and phosphoramidite synthesis strategies were combined to add florfenicol to the Fmoc-protected tyrosine phosphate via a phosphodiester, which can be cleaved by nucleases produced by bacteria. Encouraging results showed the formation of the targeted compound, paving the way for the design of a self-defensive antibacterial peptide
Molina, Eduardo Ferreira [UNESP]. "Matrizes híbridas siloxano-poliéter para liberação controlada de fármacos." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/105769.
Résume: La capacité d'assemblage de composants organique, inorganique, et même bioactifs dans un matériel unique représente une orientation intéressante pour développer des nouveau matériaux multifonctionnels hybride. Dans ces hybrides, l'association des caractéristiques des composés organiques et inorganiques permet à de nouveaux matériaux présentant des propriétés uniques telles que la résistance mécanique élevée, la transparence et de souplesse, étant adaptée à une application dans plusieurs domaines scientifiques et technologiques, y compris ceux de santé humaine. Cette these se concentre sur la relation entre la structure et les propriétés de libération des molécules anti-inflammatoire (diclofenac sodium) et à base de platine antitumorale (cisplatine) incorporées dans des matériaux siloxane polyéther. Pour parvenir à un contrôle précis du taux de libération du médicament, différentes proportions de polymères hydrophilic (PEO)/hydrophobic (PPO) ont été combinés. Ces matrices ont été préparées par mélange de différentes fractions de précurseurs hybrides siloxane-poly (oxyde d'éthylène) (PEO) et siloxane-poly (oxyde de propylène) (PPO). Molécules de médicaments ont été incorporée lors des étapes de l’hydrolyse et polycondensation. La structure nanoscopique de xérogel a été analysée par difusion de la lumiere à petites angles (SAXS) et les propriétés de libération du médicament par les UVvis spectroscopie. En plus la structure de le médicament cisplatine incorporés dans les matrices hybrides a été étudiée atravers de la couplage de Raman-UVvis et EXAFS spectroscopies. Les résultats (SAXS) montrent que la structure nanoscopie de tous les hybrides siloxane polyéther peut être décrite par un modèle de deux densités életroniques. La distance régulière entre les domaines inorganiques imposées... (Résume complet accès électronique ci-dessous)
A capacidade de moldar materiais a partir de componentes orgânicos, inorgânicos, e mesmo bioativos em uma única direção é interessante para desenvolver novos materiais híbridos multifuncionais. Nesses híbridos, a associação das características dos compostos orgânicos e inorgânicos permite obter novos materiais com propriedades únicas como alta resistência mecânica, transparência e flexibilidade, sendo adequado para aplicação em vários campos da ciência e tecnologia, incluindo as da saúde humana. Esta tese foca a relação entre estrutura e propriedades de liberação de moléculas antiinflamatórias (diclofenaco de sódio DCFNa) e antitumoral a base de platina (cisplatina CisPt) incorporada em materiais siloxano-poliéter. Para conseguir um controle preciso da taxa de liberação dos fármacos, diferentes proporções de polímeros hidrofílicos (PEO)/hidrofóbicas (PPO) foram combinados. Essas matrizes foram preparadas pela mistura de diferentes proporções de precursor híbrido de siloxano-poli (óxido de etileno) (PEO) e siloxano-poli (óxido de propileno) (PPO). Moléculas do fármaco foram incorporadas durante as etapas de hidrólise e policondensação. A estrutura nanoscopica dos xerogéis foi analisada por espalhamento de raios X a baixos ângulos (SAXS) e as propriedades de liberação do fármaco por espectroscopia UV-vis. Além disso, a estrutura do fármaco cisplatina incorporado nas matrizes híbridas foi estudada através de medidas simmultaneas UV-vis-Raman e espectroscopia EXAFS. Os resultados (SAXS) mostram que a estrutura nanoscopia de todos os híbridos siloxano-poliéter pode ser descrita por um modelo de duas densidades eletrônicas. A distância medias de correlação entre os domínios inorgânicos impostas pelo tamanho das cadeias poliméricas foi confirmada pelo pico de correlação observada nas curvas de SAXS. Isto foi confirmado pela...
Molina, Eduardo Ferreira. "Matrizes híbridas siloxano-poliéter para liberação controlada de fármacos /." Araraquara : [s.n.], 2010. http://hdl.handle.net/11449/105769.
Résume: La capacité d'assemblage de composants organique, inorganique, et même bioactifs dans un matériel unique représente une orientation intéressante pour développer des nouveau matériaux multifonctionnels hybride. Dans ces hybrides, l'association des caractéristiques des composés organiques et inorganiques permet à de nouveaux matériaux présentant des propriétés uniques telles que la résistance mécanique élevée, la transparence et de souplesse, étant adaptée à une application dans plusieurs domaines scientifiques et technologiques, y compris ceux de santé humaine. Cette these se concentre sur la relation entre la structure et les propriétés de libération des molécules anti-inflammatoire (diclofenac sodium) et à base de platine antitumorale (cisplatine) incorporées dans des matériaux siloxane polyéther. Pour parvenir à un contrôle précis du taux de libération du médicament, différentes proportions de polymères hydrophilic (PEO)/hydrophobic (PPO) ont été combinés. Ces matrices ont été préparées par mélange de différentes fractions de précurseurs hybrides siloxane-poly (oxyde d'éthylène) (PEO) et siloxane-poly (oxyde de propylène) (PPO). Molécules de médicaments ont été incorporée lors des étapes de l'hydrolyse et polycondensation. La structure nanoscopique de xérogel a été analysée par difusion de la lumiere à petites angles (SAXS) et les propriétés de libération du médicament par les UVvis spectroscopie. En plus la structure de le médicament cisplatine incorporés dans les matrices hybrides a été étudiée atravers de la couplage de Raman-UVvis et EXAFS spectroscopies. Les résultats (SAXS) montrent que la structure nanoscopie de tous les hybrides siloxane polyéther peut être décrite par un modèle de deux densités életroniques. La distance régulière entre les domaines inorganiques imposées... (Résume complet accès électronique ci-dessous)
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Marano, Stefania. "The development of microfibrous matrices prepared using centrifugal spinning for the oral delivery of poorly water-soluble drugs." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10040259/.
Thumma, Sridhar. "Characterization of water insoluble and water soluble drugs in hot-melt poly (ethylene oxide) matrices for oral transmucosal delivery /." Full text available from ProQuest UM Digital Dissertations, 2008. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1850456491&SrchMode=1&sid=3&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1279304005&clientId=22256.
Typescript. Vita. "March 2008." Major professor: Dr. Michael Repka Includes bibliographical references (leaves 306-326). Also available online via ProQuest to authorized users.
RODRIGUES, KIRIAKI M. S. "Influência de polietilenoglicol (PEG) na liberação modificada de teofilina em comprimidos de poli-3-midroxibutirato (PHB) e poli-e-caprolactona (PCL)." reponame:Repositório Institucional do IPEN, 2008. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10155.
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Ishizawa, Higuchi Claudia Inés. "Hydrogel à base de chitosane-xanthane : une matrice pour l'inclusion et le relargage de médicaments = Chitosan-xanthan hydrogel : a matrix for the inclusion and the delivery of drugs." Sherbrooke : Université de Sherbrooke, 2002.
Laurent, Morgane. "Utilisation d'une décharge à barrière diélectrique pour développer une matrice polymère plasma dégradable pour des applications vasculaires." Thesis, Université Laval, 2017. http://www.theses.fr/2017TOU30189/document.
Every year, about 1.5 million patients need a vascular replacement due to advanced arteriosclerosis, which causes the internal narrowing of blood vessels. Unfortunately, even today the synthetic materials used to replace small diameter arteries (below 6 mm) remain associated with low patency rate, which demonstrates an evident lack of biocompatibility. One of the main observed complications is arterial neointimal hyperplasia, which is characterized by the blood vessel obstruction due to the tridimensional proliferation of cells on the graft internal wall. Different strategies aiming at limiting this body reaction are currently considered, in particular the use of a drug delivery system locally integrated to the vascular grafts. Concurrently, the rise of plasma technologies enabled to demonstrate the possibility to coat the surface of biomedical devices to improve their interaction with a biological environment. The strategy consists in using the plasma energy and reactivity to polymerize a gaseous precursor. By selecting the appropriate precursor molecular structure and plasma experimental conditions, one can build up a plasma polymer with tailored properties. It is in this context that this thesis consisted in synthesizing, using plasma, a biodegradable polymeric plasma polymer matrix to coat the internal wall of a vascular graft, with the goal to incorporate a drug chosen to limit neointimal hyperplasia. On one hand, this project acted as proof of concept by developing a degradable plasma polymer coating using a planar dielectric barrier discharge. After extensive studies using ethyl lactate as precursor, optimal chemical vapor deposition conditions were elected for their potential in terms of vascular applications. On the other hand, thanks to an extended discharge characterization, a strong correlation was established between the plasma physico-chemistry and the properties of the degradable coatings synthesized. In addition, to broaden possibilities in terms of degradation rate, the influence of a squared pulse power supply on the discharge and the coating was studied. If changing the way to bring the energy had a strong influence on the discharge, no major influence was noticed on the ethyl lactate-based coatings' chemistry and morphology. Finally, a tubular plasma reactor was build up to empower the internal wall of vascular prosthesis to be coated, which enabled to extend this project to the deposition conditions of its final application. Overall, this research project highlighted the potential of plasma processes for the development of degradable plasma polymer matrices, particularly for local drug delivery systems for vascular applications. On a physics perspective, this work emphasized the importance of studying the discharge under actual thin layer deposition conditions
Forlivesi, Claudio. "Biomateriali e 3D bioprinting nella rigenerazione neurale." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/17888/.
Papežíková, Hana. "Potenciál využití semi-interpenetrovaných polymerních sítí na bázi poly-HEMA v moderních nosičových systémech." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2021. http://www.nusl.cz/ntk/nusl-449370.
Dott, Clare. "Highly resilient fibrous matrices for rapid drug delivery." Thesis, 2011. http://hdl.handle.net/10539/10831.
Adeleke, Oluwatoyin Ayotomilola. "Design and mechanistic evaluation of novel pore-regulated polymer matrices for transmucosal drug delivery." Thesis, 2012. http://hdl.handle.net/10539/11308.
CASTROFLORIO, BENEDETTA. "Functional Nanostructured Materials as Matrices for Controlled Release." Doctoral thesis, 2015. http://hdl.handle.net/2158/985206.
Johnson, Michelle Linette. "Polyanhydride blends as drug delivery matrices to control biofilms, bone and nerve regeneration." 2008. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17333.
Hurbans, Nivriti. "Formulation and evaluation of modified release eudragit® matrices containing diclofenac sodium." Thesis, 1998. http://hdl.handle.net/10413/4688.
Thesis (M.Sc.)-University of Durban-Westville, 1998.
Domingues, Nabais Maria Teresa. "High-amylose carboxymethyl starch matrices for oral sustained drug-release : in vitro and in vivo evaluation." Thèse, 2013. http://hdl.handle.net/1866/10943.
Unmodified and modified starches represent a particularly interesting group of biodegradable and abundant excipients. They have been widely used as excipients for various purposes in tablet formulations, such as binders and/or disintegrants. Spray-dried high-amylose sodium carboxymethyl starch (SD HASCA) was recently proposed as an innovating hydrophilic excipient for sustained-release (SR) in solid oral dosage forms. Amorphous high-amylose sodium carboxymethyl starch (HASCA) was first produced by the etherification of high-amylose corn starch with chloroacetate. HASCA was then spray dried to obtain SD HASCA. This new excipient has shown advantageous and effective properties in the production of SR delivery systems. SR matrix tablets prepared from SD HASCA are inexpensive, simple to formulate and easy to produce by direct compression. The main objective of the present research was to continue the development and optimization of matrix tablets using SD HASCA as the retarding excipient in view of their ultimate application as sustained drug-release delivery systems for oral administration. For this purpose, dissolution tests simulating some of the most relevant physiological conditions of the gastrointestinal tract, taking into account the nature of the polymer under investigation, were employed to evaluate the drug-release characteristics and demonstrate the performance of SD HASCA SR formulations. An exploratory clinical study was also carried out to evaluate the SR properties of this new drug delivery system in the gastrointestinal tract. The first article presented in this thesis evaluated the drug-release characteristics and the physical integrity of formulations containing a compressed blend of drug, sodium chloride and SD HASCA in biorelevant media. The influence of different acidic pH values and residence times was investigated. The SR profile from an optimized SD HASCA formulation was not significantly affected by both the acidic pH value and the residence time in the acidic medium. These results suggest a limited influence of intra- and inter-subject variability of gastric pH on the release kinetics from SD HASCA matrices. In addition, the optimized formulation maintained its integrity throughout the duration of the dissolution tests. The exploratory in vivo study demonstrated extended drug absorption after oral administration of SD HASCA matrix tablets and that the matrix tablets did not disintegrate while passing through the stomach and resisted hydrolysis by α-amylase in the intestine. The second article reports the development of once-daily and twice-daily SD HASCA tablets containing tramadol hydrochloride (100 mg and 200 mg). These SR formulations presented high crushing strengths without requiring the addition of binders, which facilitates tablet processing and handling. The compression force (CF) applied to produce the tablets did not significantly affect the drug-release profiles. The total release time from SD HASCA tablets increased significantly in function of the tablet weight and can be used to modulate the total release time from theses formulations. When exposed to a pH gradient and to a 40% ethanol medium, a very rigid gel formed progressively on the surface of the tablets providing controlled drug-release properties. These properties indicated that SD HASCA is a robust excipient for oral, sustained drug-release, likely to minimize the possibility of dose dumping and consequent adverse effects, even when co-administered with high doses of alcohol. The third article investigated the effect of α-amylase on drug-release from previously developed SD HASCA tablets containing acetaminophen and tramadol hydrochloride (Acetaminophen SR and Tramadol SR). Mathematical modeling showed that an increase in α-amylase concentration resulted in an increase of polymer erosion over drug diffusion as the main mechanism controlling drug-release, for both formulations and both residence times in acidic medium. However, even if the mechanism of release was affected, α-amylase concentrations ranging from 0 IU/L to 20000 IU/L did not significantly affect the drug-release profiles from SD HASCA SR tablets, regardless of the residence time in acidic medium, the drug used, the polymer content and the different composition of each formulation. The work presented in this thesis clearly demonstrates the value of SD HASCA as an efficient SR excipient.