Готові списки джерел за темами / Drug delivery matrices

Добірка наукової літератури з теми "Drug delivery matrices"

Автор: Grafiati

Опубліковано: 7 липня 2024

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Статті в журналах з теми "Drug delivery matrices":

You, Jin-Oh, Dariela Almeda, George JC Ye, and Debra T. Auguste. "Bioresponsive matrices in drug delivery." Journal of Biological Engineering 4, no. 1 (2010): 15. http://dx.doi.org/10.1186/1754-1611-4-15.

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Nayak, Amit K., Md Saquib Hasnain, Sitansu S. Nanda, and Dong K. Yi. "Hydroxyapatite-alginate Based Matrices for Drug Delivery." Current Pharmaceutical Design 25, no. 31 (November 14, 2019): 3406–16. http://dx.doi.org/10.2174/1381612825666190906164003.

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Background: Hydroxyapatite (HAp) is a biocompatible bioceramic compound by nature and widely utilized in a broad range of biomedical applications, especially in drug delivery, tissue engineering, orthopedics, dentistry, etc. To intensify its usage, HAp is being reinforced with different biopolymer(s). In these bioceramicbiopolymeric systems, HAp crystallites have been well inviolate with the alginate molecules. The objective of this review article is to present a comprehensive discussion of different recently researched drug-releasing potential by HAp-alginate based matrices. Methods: During past few years, HAp particles (both synthesized and naturally derived) have been reinforced within different alginate-based systems to load a variety of drug candidates. Most of the reported drug-releasing HAp-alginate based matrices were prepared by the methodology of ionic-gelation of sodium alginate followed by air-drying/spray drying process. Results: HAp-alginate systems have already been proved as useful for loading a variety of drugs and also resulting sustained drug delivery with minimizing the drawbacks of pure alginate matrices (such as burst drug-releasing and low mechanical property in the alkaline pH). Conclusion: HAp-alginate composites loaded with different kinds of drugs have already been reported to exhibit sustained releasing of loaded drugs over a longer period.

Manzano, Miguel, Montserrat Colilla, and María Vallet-Regí. "Drug delivery from ordered mesoporous matrices." Expert Opinion on Drug Delivery 6, no. 12 (November 26, 2009): 1383–400. http://dx.doi.org/10.1517/17425240903304024.

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Mucha, Maria, Iwona Socha-Michalak, and Jacek Balcerzak. "Biodegradable Polymers as Matrices for Control Drug Delivery." Advanced Materials Research 911 (March 2014): 336–41. http://dx.doi.org/10.4028/www.scientific.net/amr.911.336.

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In the paper the results of control drug release from different forms of carriers are presented. Dibutyrylchitin, chitosan, polylactid acid and polycaprolactone have been used as matrices for delivery of therapeutic substances (ibuprofen and salicylic acid). Two configurations of matrices for drug delivery have been found. Flat drug delivery systems (films) and spherical matrices (beads) were tested in the aim of control drug transport. To control the drug release, matrices have been modified. The release of active substances from films has been tested in buffer solution of pH 5.5. Spherical matrices have been tested in buffer solutions of pH 1.4 and pH 7.2. To experimental data First order and two stage models were fitted.

Chiarappa, Gianluca, Michela Abrami, Barbara Dapas, Rossella Farra, Fabio Trebez, Francesco Musiani, Gabriele Grassi, and Mario Grassi. "Mathematical Modeling of Drug Release from Natural Polysaccharides Based Matrices." Natural Product Communications 12, no. 6 (June 2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200610.

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The new concept of personalized medicine and the affirmation of Nucleic Acid Based Drugs (NABDs), an emerging class of bio-drugs constituted by short sequences of either DNA or RNA, represent a new challenge for the mathematical modelling in the drug delivery and adsorption field. Indeed, whether patient uniqueness asks for the use of theoretical tools enabling a rational approach adapting to each patient, NABDs delivery brings to our attention new aspects of drug delivery due to the NABDs fragile nature and way of action. This review aims to present and discuss the mathematical modelling of drug release from natural polysaccharides matrices with particular care to the description of the chemical and physical phenomena ruling drug delivery.

Singh, Shrishti, and Jeffrey Moran. "Autonomously Propelled Colloids for Penetration and Payload Delivery in Complex Extracellular Matrices." Micromachines 12, no. 10 (October 6, 2021): 1216. http://dx.doi.org/10.3390/mi12101216.

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For effective treatment of diseases such as cancer or fibrosis, it is essential to deliver therapeutic agents such as drugs to the diseased tissue, but these diseased sites are surrounded by a dense network of fibers, cells, and proteins known as the extracellular matrix (ECM). The ECM forms a barrier between the diseased cells and blood circulation, the main route of administration of most drug delivery nanoparticles. Hence, a stiff ECM impedes drug delivery by limiting the transport of drugs to the diseased tissue. The use of self-propelled particles (SPPs) that can move in a directional manner with the application of physical or chemical forces can help in increasing the drug delivery efficiency. Here, we provide a comprehensive look at the current ECM models in use to mimic the in vivo diseased states, the different types of SPPs that have been experimentally tested in these models, and suggest directions for future research toward clinical translation of SPPs in diverse biomedical settings.

Cheaburu-Yilmaz, Catalina, Catalina Lupuşoru, and Cornelia Vasile. "New Alginate/PNIPAAm Matrices for Drug Delivery." Polymers 11, no. 2 (February 20, 2019): 366. http://dx.doi.org/10.3390/polym11020366.

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This paper deals with a comparative study on the interpolymeric complexes of alginate poly(N-isopropyl acryl amide (PNIPAAm) and corresponding graft copolymers with various compositions in respect to their toxicity, biocompatibility and in vitro and in vivo release of theophylline (THP). Loading of the various matrices with theophylline and characterization of loaded matrices was studied by near infrared spectroscopy–chemical imaging (NIR–CI) analysis, scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). It was appreciated that THP loading is higher than 40% and the drug is relatively homogeneous distributed within all matrices because of some specific interactions between components of the system. All samples have been found to be non-toxic and biocompatible. It was established that graft copolymers having a good stability show a better drug carrier ability, a higher THP loading, a prolonged release (longer release duration for graft copolymers of 235.4–302.3 min than that for IPC 72/28 of 77.6 min, which means approximately four times slower release from the graft copolymer-based matrices than from the interpolymeric complex) and a good bioavailability. The highest values for THP loading (45%), prolonged release (302.3 min) and bioavailability (175%) were obtained for graft copolymer AgA-g-PNIPAAm 68. The drug release mechanism varies with composition and architecture of the matrix.

Ezzat, Kariem, Samir Andaloussi, Rania Abdo, and Ulo Langel. "Peptide-Based Matrices as Drug Delivery Vehicles." Current Pharmaceutical Design 16, no. 9 (March 1, 2010): 1167–78. http://dx.doi.org/10.2174/138161210790963832.

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Moghadam, S. H., H. W. Wang, E. Saddar El-Leithy, C. Chebli, and L. Cartilier. "Substituted amylose matrices for oral drug delivery." Biomedical Materials 2, no. 1 (March 2007): S71—S77. http://dx.doi.org/10.1088/1748-6041/2/1/s11.

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Foster, Thomas, Corina Ionescu, Daniel Walker, Melissa Jones, Susbin Wagle, Božica Kovacevic, Daniel Brown, Momir Mikov, Armin Mooranian, and Hani Al-Salami. "Chemotherapy-induced hearing loss: the applications of bio-nanotechnologies and bile acid-based delivery matrices." Therapeutic Delivery 12, no. 10 (October 2021): 723–37. http://dx.doi.org/10.4155/tde-2021-0050.

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Advancement in the prevention of chemotherapy-induced hearing loss has proposed new nano-based delivery matrices that can target inner ear regions most damaged by chemotherapy. Chemotherapy agents (e.g., cisplatin) induce increased reactive oxygen species formation in the inner ear that damage sensory hair cells and result in irreversible hearing impairment. Exogenous antioxidants (e.g., Probucol and metformin) have been shown to block the formation of these reactive oxygen species. Delivery of these drugs in effective concentrations remains a challenge. Microencapsulation in combination with drug excipients provides one technique to effectively deliver these drugs. This paper investigates the use of probucol and metformin in combination with drug excipients for novel, inner ear, delivery.

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Дисертації з теми "Drug delivery matrices":

Feely, L. C. "Controlled release hydroxypropylmethylcellulose mini-matrices." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373348.

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Wang, Yiwei. "Improving 3D matrices for tissue engineering using advanced drug delivery techniques." Thesis, Kingston University, 2007. http://eprints.kingston.ac.uk/20391/.

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Micro/macroporous matrices comprising a continuous phase of poly([epsilon]-caprolactone) . (PCL) and a dispersed phase of water soluble particles (lactose and gelatin) with defined size range (45-90, 90-125 and l25-250[mu]m) were produced by rapid cooling solutions of PCL in acetone followed by solvent extraction from the hardened material. This novel approach enables high loading (29-44% w/w) of particles (lactose and gelatin) to be achieved in PCL matrices by suspension of particulates in the PCL solution prior to casting. Highly efficient protein release (90%) was obtained over time periods of 3 days to 3 weeks by variation of particle loading and particle size range. The good particle distribution throughout the matrix and efficient extraction of the water-soluble phase allows formation of a macroporous structure with defined pore architecture by incorporation of particles of a specific shape and size range. SEM analysis revealed the porous surface morphology. Micro computed tomography (micro-CT) and image analysis enabled visualization of the internal 3-D pore structure, quantification of the frequency distribution of equivalent pore diameter and porosity (%) in peL matrices. Micro/macroporous PCL tubes exhibited a burst strength of 125 to l45MPa under hydrostatic loading at 37[degree]C and good recovery of tube diameter following short-duration flow rates of 1000 ml/min under continuous increasing and pulsatile conditions. Sustained release of incorporated enzymes (lysozyme, collagenase and catalase) occurred over 11 days from the PCL matrices, with retained activity dependent on the particular enzyme used (collagenase 100% at 11 days, lysozyme 75-80% at 11 days, catalase 10-20 % at 5 days). Swiss3T3 fibroblasts exhibited strong attachment and successful colonization of the surface. of PCL matrices over 8 to 15 days in cell culture. These findings demonstrate the potential of micro/macroporous PCL matrices for scaffold production in tissue engineering and for controlling drug delivery.

Pywell, E. J. "Studies on some polymeric matrices for use in transdermal drug delivery systems." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378309.

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Caldwell, Deborah Leigh. "Characterisation of drug loaded insoluble polymeric matrices prepared by hot melt extrusion technology for drug delivery applications." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.579769.

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In this work. polymeric matrices comprising Eudragit" RL PO were manufactured using Hot Melt Extrusion (HME) technology. The thermal, physical and chemical characteristics of Eudragit'" RL PO were investigated and suitable processing parameters defined. Above 180°C, thermal decomposition proceeded by a mechanism which caused cleavage and subsequent loss of ammonio methacrylate functional groups. Acceptable processing limits for HME of Eudragit" RL PO were defined with an optimal temperature window between 120°C and 170°C and screw speed between 100 and 150rpm. Ingress of water as a liquid and vapour changed the physical and viscoelastic properties of the material. A model water soluble drug, metformin hydrochloride (MHCI), was formulated within the Eudragit'" RL PO carrier matrix using via HME. MHCI and Eudragit" RL PO exhibited a poor interaction and MHCI displayed a low solubility in the molten polymer matrix. PXRD showed that crystalline solid dispersions formed during HME at all concentrations. Addition of Eudragit" RS PO to the hot melt formulation also caused retardation of drug release from the matrix providing a mechanism through which release of MHCI could be sustained. The effect of drug salt form on the physiochemical and drug release properties was evaluated using quinine as the free base (QB), hydrochloride (QHCI) and sulphate (QS04) forms. A significant difference in solubility in the molten polymer matrix was observed for each of the quinine forms. QB, QHCI and QS04 acted as solid-state plasticizers for Eudragit" RL PO at concentrations below saturation solubility. Salt counter ion imparted a significant influence on the solubility of drug within the polymer matrix. FT-IR and Raman spectroscopy showed that quinine exhibited multiple sites of interaction and the formation of a salt occupied a key site of interaction which rendered the salt forms less soluble in the molten polymer matrix which in turn affected the physiochemical and drug release properties from hot melt extrudates. Rheological characteri ation using capillary rheometry showed that Eudragit" RL PO exhibited non ewtonian flow behaviour. Power law index and activation energy (Ea) were calculated for the pure polymer. Shear rate did not exert a significant influence on the Eudragit" RL PO microstructre post processing and the glass transition temperature and water uptake properties of the polymer remained unchanged. Significant die swell post processing was observed and was counteracted by increasing the length of extrusion die. Addition of QB to the formulation caused an improvement in the thermal processability of the material due to solid-state plasticization of the polymer. Application of a drawing force on the drug release properties from QB loaded Eudragit" RL PO extrudates were evaluated and no significant difference in the dissolution properties were observed at any of the applied drawing forces.

Kuduğ, Emre Batıgün Ayşegül. "Use Of Fibroin/Hyaluronic Acid Matrices As A Drug Reservoir In Iontophoretic Transdermal Delivery/." [s.l.]: [s.n.], 2004. http://library.iyte.edu.tr/tezler/master/kimyamuh/T000297.pdf.

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Melocchi, A. "INJECTION MOLDING/MICROMOLDING APPLICATIONS TO DRUG DELIVERY." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/251825.

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In the present work the application potential of injection molding (IM) and micromolding (µIM) for the manufacturing of drug products was investigated. These techniques are largely employed in the plastics industry to process thermoplastic polymers into objects with different size, shape and possibly many details, and they could offer several advantages in the pharmaceutical area, mainly related to versatility, patentability, scalability and production costs (continuous manufacturing). Processes and equipment generally employed as well as current pharmaceutical applications already proposed in the literature were preliminarily reviewed. Drug delivery systems (DDSs) in the form of gastro-resistant containers based on HPMCAS were afterwards designed and manufactured by µIM. Notably, such DDSs represent a step forward in the field as they may provide a ready-to-use alternative to enteric-coated dosage forms. Moreover, the feasibility by hot-processing techniques (hot melt extrusion and IM) of prolonged-release hydrophilic matrices and immediate release tablets was demonstrated, which could help promoting the use of continuous manufacturing in the pharmaceutical production areas.

Liu, Haoyu. "Synthesis and Structure-property Evaluation of Novel Cellulosic Polymers as Amorphous Solid Dispersion Matrices for Enhanced Oral Drug Delivery." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/54934.

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The use of amorphous solid dispersions (ASDs) is an effective and increasingly widely adopted approach for solubility and bioavailability enhancement of hydrophobic drugs. Cellulose derivatives have strong potential as ASD polymers. We demonstrate herein design, synthesis and structure-property relationship characterization of a new series of organo-soluble cellulose omega-carboxyalkanoates for ASDs, by two different synthetic approaches. These carboxyl-containing cellulose mixed-esters possessed relatively high Tg values with sufficient differences versus ambient temperature, useful to prevent drug mobility and crystallization during storage or transport. Screening experiments were utilized to study the impact of ASD polymers including our new family of cellulose Ω-carboxyesters on both nucleation induction time and crystal growth rate of three poorly soluble model drugs from supersaturated solutions. Attributed to relatively rigid structures and bulky substituent groups, cellulose derivatives were more significant crystallization inhibitors compared to the synthetic polymers. The effective cellulose omega-carboxyesters were identified as possessing a similar hydrophobicity to the drug molecule and high number of ionization groups. Among them, cellulose acetate suberate prepared by us was an extraordinary solution crystal growth inhibitor for ritonavir and its formulated solid dispersions provided a substantial 15-fold enhancement of apparent solution concentration vs. the equilibrium solubility of the crystalline drug. To offset the issue of slow drug release from some cellulose omega-carboxyester based formulations, a new class of amphiphilic cellulosic polymers with hydrophilic oligo(ethylene oxide)-containing side chains was developed via versatile synthetic pathways, and the evaluation of these materials alone or by pairwise polymer blends will be performed as ASD matrices for the enhancement of drug solubility and stability.
Ph. D.

FEDERICO, Salvatore. "Advanced electrospun matrices based on polysaccharide derivatives for applications in regenerative medicine." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/521949.

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The complete regeneration of damaged human tissues and organs is still a significant challenge. The integrative use of biomaterials, cells and bioactive factors in all-in-one devices exploits all current knowledge of materials science, nanotechnology and stem cell biology to best mimic the complex hierarchical architecture of native tissues. The artificial microenvironment design must be properly tuned to match the physicochemical features of the target, offering adequate nanoscale patterns and biological domains for cellular interactions. Scaffolds must promote and guide the regeneration route by mimicking host signalling pathways through the controlled release and retention of drugs or growth factors. For these purposes, polysaccharides have been often used and proposed to manufacture bioengineered scaffolds for regenerative medicine applications due to high biomimetic characteristics. The efforts made by researchers have highlighted how the cellular interactions with electrospun biomaterials offer excellent performances to achieve the desired differentiation and integration with the surrounding tissue. Alkyl derivatives of gellan gum (GG) and hyaluronic acid (HA) have been investigated as novel bioactive electrospun membranes for wound healing and periodontal regeneration. In this thesis, all the derivatives of these two polysaccharides have been produced via activation of the primary hydroxyl groups of β-glucose of gellan gum or N-acetyl-D-glucosamine of hyaluronic acid with bis(4-nitrophenyl) carbonate and the grafts of aliphatic chains at a different length. For hyaluronic derivatives, small moieties with free amino groups have been additionally inserted with the same chemistry. Membranes based on the octyl- and dodecyl-derivative of gellan gum (GG-C8 and GG-C12) have been produced by electrospinning and characterized in terms of fiber distribution and orientation verifying the improved processability of the polymers compared to native gellan gum. Rheological analyses have studied the influence of alkyl derivatization on the spinnability of blends. The feasibility of the process regarded the octyl-derivative one, so the swelling ability of such scaffold has been analyzed under physiological conditions after crosslinking with calcium chloride at different concentrations. To treat partial-thickness wounds, the membrane has been proposed to improve the cell homing at the damaged site, the adhesion of cells, and to encourage the regeneration of the extracellular matrix lost. Similar instrumental settings are used to incorporate the growth factor FGF-2 in the octyl-based membrane (GG-C8). The study has investigated physical interactions between the active and the polymer and how the ionotropic sensitivity of the GG-C8 could be exploited to assess a suitable FGF-2 releasing profile. The fabrication of the bilayer biodevice has involved a hydrophilic layer covered by a synthetic polyurethane layer loaded with ciprofloxacin. Considering the crosslinking degree of the membrane, the dissolution rate and the releases of FGF-2 and ciprofloxacin have been valued with Franz cells. The antibacterial effect of the bilayer has been investigated against the inhibition of units forming colonies of Staphylococcus aureus in the timeframe compatible with the complete regeneration of the tissue. The chemoattraction ability of the scaffold and the cytocompatibility have been tested using cultures of human fibroblasts (NIH3T3) by a specific migration assay. Electrospun membranes based on four chemical derivatives of hyaluronic acid at increasing hydrophobic character have been prepared and loaded with dexamethasone (a known osteoinductive drug) to induce osteogenic differentiation in pre-osteoblasts (MC3T3). The fibrillar supports have been characterized with a scanning electron microscope, and the hydrolytic and enzymatic degradation, as well as dexamethasone releases, have been tested after an autocrosslinking procedure. HA membranes have been designed as guided-bone regeneration barriers for periodontal regeneration; thus, wettability properties and biological performances have been investigated. The proliferation of cells above membranes is valued for up to seven days, and in vitro osteogenic induction is followed by quantifying the activity of alkaline phosphatases and evaluating the calcium content after one month of MC3T3 cultures. The final aim of the thesis is to fabricate a hyaluronan based membrane with high antibacterial properties for the healing of chronic wounds. The proposed membrane consists of incorporating graphene oxide in an electrospun membrane of a hydrophilic derivative of HA loaded with ciprofloxacin. According to an external laser stimulation in the near-infrared, the drug-releasing profile and hyperthermal features have been studied and related to the ability to eradicate bacterial infections and inhibit the generation of biofilm. The cytocompatibility has been valued culturing fibroblasts for up to three days, and the membrane was valued as a wound dressing system.

Wang, Qing. "STRATEGIES FOR SUSTAINED RELEASE OF SMALL HYDROPHILIC DRUGS FROM HYDROGEL BASED MATRICES." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1515164088562922.

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Batista, Jorge Gabriel dos Santos. "Desenvolvimento de matrizes poliméricas biodegradáveis à base de quitosana e possíveis blendas como sistemas de liberação controlada de fármacos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-18022016-145449/.

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De acordo com o conceito de sistemas de liberação controlada, o presente estudo foi baseado na utilização de polímeros hidrofílicos biocompatíveis, formadores de hidrogéis, para o desenvolvimento de matrizes na forma de filmes finos. Os polímeros utilizados para a formação das matrizes foram a quitosana proveniente das cascas de camarão, o amido de milho modificado e a poli(N-vinil-2-pirrolidona) - PVP. As matrizes foram reticuladas utilizando glutaraldeído. O fármaco escolhido para testar a capacidade de liberação dos dispositivos foi o anti-inflamatório não esteroidal (AINE) diclofenaco sódico. Para obtenção das matrizes com propriedades adequadas para essa finalidade, foram testadas misturas de quitosana-amido e quitosana-PVP. Após a triagem qualitativa, os dispositivos foram avaliados quanto à citotoxidade, intumescimento máximo, fração gel, parâmetros cinéticos associados à absorção de vapor de água e à capacidade de liberação de diclofenaco sódico in vitro. As formulações de quitosana-PVP foram as que apresentaram melhores propriedades para a aplicação proposta nesse estudo, se destacando a formulação A3, com alto percentual de liberação, boas propriedades de manuseio, poucos componentes na formulação diminuindo o potencial alergênico e aprovação no teste de citotoxicidade em células de camundongo (NCTC) pelo método de incorporação do vermelho neutro.
According to the concept of drug delivery systems, this study has based on the use of biocompatible hydrophilic polymers hydrogels-forming for the development of matrices in the form of thin films. The polymers used for forming the matrices were chitosan from shrimp shells, modified maize starch and poly(N-vinyl-2-pyrrolidone) PVP. The matrices were cross-linked using glutaraldehyde. The drug chosen to test the ability of the devices release was the non-steroidal anti-inflammatory drug (NSAID) sodium diclofenac. Mixtures between chitosan-starch and chitosan-PVP tested to obtain the matrices with suitable properties for this purpose. The devices after qualitative screening had evaluated for cytotoxicity, maximum swelling, gel fraction, kinetic parameters associated with absorbing water vapor and the release of diclofenac sodium able to in vitro. The formulations based on chitosan-PVP were the presents the best properties, in evidence formulation A3, with high percentage of delivery, good handing properties, few compounds/components reducing the allergenic potential and successful in vitro cell viability red uptake cytotoxicity assay, using cell culture mouse cells (NCTC).

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Книги з теми "Drug delivery matrices":

Svenson, Sonke. Polymeric Drug Delivery: Volume II: Polymeric Matrices and Drug Particle Engineering (Acs Symposium Series). An American Chemical Society Publication, 2006.

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Частини книг з теми "Drug delivery matrices":

Pachuau, Lalduhsanga. "Application of Nanocellulose for Controlled Drug Delivery." In Nanocellulose and Nanohydrogel Matrices, 1–19. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2017. http://dx.doi.org/10.1002/9783527803835.ch1.

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Akram, Muhammad, and Rafaqat Hussain. "Nanohydrogels: History, Development, and Applications in Drug Delivery." In Nanocellulose and Nanohydrogel Matrices, 297–330. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2017. http://dx.doi.org/10.1002/9783527803835.ch11.

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Moscovici, Misu, Cristina Hlevca, Angela Casarica, and Ramona-Daniela Pavaloiu. "Nanocellulose and Nanogels as Modern Drug Delivery Systems." In Nanocellulose and Nanohydrogel Matrices, 209–69. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2017. http://dx.doi.org/10.1002/9783527803835.ch9.

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Tiwari, Sandip B., James DiNunzio, and Ali Rajabi-Siahboomi. "Drug–Polymer Matrices for Extended Release." In Controlled Release in Oral Drug Delivery, 131–59. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-1004-1_7.

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Roveri, Norberto, and Michele Iafisco. "Biomimetic Nanostructured Apatitic Matrices for Drug Delivery." In Biomimetic Approaches for Biomaterials Development, 381–416. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527652273.ch17.

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Greenley, Robert Z., Hossein Zia, Joel Garbow, and Robert L. Rodgers. "Cross-Linked Polyacid Matrices for Oral Drug Delivery." In ACS Symposium Series, 213–36. Washington, DC: American Chemical Society, 1991. http://dx.doi.org/10.1021/bk-1991-0469.ch020.

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Wen, Xiaoguang, Ali Nokhodchi, and Ali Rajabi-Siahboomi. "Oral Extended Release Hydrophilic Matrices: Formulation and Design." In Oral Controlled Release Formulation Design and Drug Delivery, 89–100. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470640487.ch6.

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Joshi, Rucha. "Creating Tunable Collagen Matrices – An Approach Inspired by In Vivo Collagen Synthesis and Self-Assembly." In Collagen Biografts for Tunable Drug Delivery, 29–51. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63817-7_3.

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Urry, Dan W. "Bioelastic Materials as Chemomechanically Transducing (“Smart”) Matrices for Drug Delivery." In Cosmetic and Pharmaceutical Applications of Polymers, 181–92. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4615-3858-5_18.

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West, Jennifer L. "In Situ Formation of Polymer Matrices for Localized Drug Delivery." In ACS Symposium Series, 119–23. Washington, DC: American Chemical Society, 1997. http://dx.doi.org/10.1021/bk-1997-0675.ch007.

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Тези доповідей конференцій з теми "Drug delivery matrices":

Ratnayake, W. R. A. P. J., J. W. Damunupola, S. Rajapakse, and A. C. A. Jayasundera. "Nanocellulose-Protein Matrices: A Model System for Controlled Drug Delivery." In International Conference on Nano Science and Nano Technology. The International Institute of Knowledge Management (TIIKM), 2018. http://dx.doi.org/10.17501/23861215.2018.5101.

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Masood, S. H., and Shivdeep Singh. "Characterization of Micro-Features in Polymeric Drug Delivery Devices Using FDM." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43298.

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This paper presents the results of the experimental work done in applying the Fused Deposition Modelling (FDM) rapid prototyping technique to fabricate and characterise the porous polymeric matrix for controlled drug delivery device (DDD). With FDM technique, both macro and micro level structures of the device matrix can be produced and controlled, which provide several advantages over the conventional techniques of DDD fabrication. The paper investigates effect of various FDM parameters viz. Raster Width, Contour Width, Air-gap and Raster Angle on the controlled drug release profiles, drug infiltration and porosity of fabricated device matrices. The paper concludes that effective DDD matrices with desired release regimes can be fabricated using FDM technology with careful selection of FDM control parameters.

Marin, Maria-Minodora, Madalina Georgiana Albu Kaya, Mihaela Violeta Ghica, Elena Danila, Gheorghe Coara, Lacramioara Popa, Ciprian Chelaru, et al. "Design and evaluation of doxycycline/collagen/chondroitin sulfate delivery systems used for cartilage regeneration." In The 8th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2020. http://dx.doi.org/10.24264/icams-2020.ii.16.

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Cartilage damage is difficult to self-heal due to an avascular microenvironment and distinct mechanical properties. These features are a challenge in designing a cartilaginous tissue with repairing effect without producing any local infections. Thus, a biodegradable scaffold in which the drug can be incorporated is preferable. Drug delivery systems based on collagen sponges have progressively become remarkable biomaterials for different medical applications. The aim of this work was to design and characterize some collagen/chondroitin sulfate supports with doxycycline for cartilage tissue regeneration. The doxycycline should prevent the development of potential infections. Collagen, chondroitin sulfate and doxycycline gels were cross-linked with different concentrations of glutaraldehyde and then freeze-dried in order to obtain collagen matrices. The structural characteristics for the new synthesized biomaterials were firstly assessed by infrared spectroscopy (FT-IR), and scaffolds morphology was then evaluated by optical microscopy and water uptake. The enzymatic biodegradation was also performed. Also, the sponges surface properties were quantified through contact angle. The in vitro doxycycline kinetics release was performed with a dissolution equipment and the release mechanism was investigated. The obtained results recommend these new scaffolds based on doxycycline/collagen/chondroitin sulfate as a promising approach for the treatment of cartilage problems.

Qiu, Weiguo, Joseph Cappello, and Xiaoyi Wu. "Fabrication of Genetically Engineered Silk-Elastin-Like Protein Polymer Fibers." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-190980.

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Micro- and submicro-diameter protein fibers are fundamental building blocks of extra- and intra-cellular matrices, providing structural support, stability and protection to cells, tissues and organism [1]. Fabricating performance fibers of both naturally derived and genetically engineered proteins has been extensively pursued for a variety of biomedical applications, including tissue engineering and drug delivery [2]. Silk-elastin-like proteins (SELPs), consisting of tandemly repeated polypeptide sequences derived from silk and elastin, have been biosynthesized using recombinant DNA technique [3]. Their potential as a biomaterials in the form of hydrogels continues to be explored [4, 5]. This study will focus on the fabrication of robust, micro-diameter SELP fibers as biomaterials for tissue engineering applications.

Vasile, Georgiana, Andreea Țigău, Alina Popescu, Rodica Roxana Constantinescu, and Laura Chirilă. "Hydrogels-Based Textile Materials for Treatment of First-Degree Burn Injuries." In The 9th International Conference on Advanced Materials and Systems. INCDTP - Leather and Footwear Research Institute (ICPI), Bucharest, Romania, 2022. http://dx.doi.org/10.24264/icams-2022.ii.28.

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Hydrogels based on collagen and xanthan have found various applications as drug delivery carriers. The main strategy is to combine the traditional perspective of using essential oils with polymeric hydrogels in order to develop a potential dressing that provides wound healing for first-degree burn injuries. In this regard, the present study is aimed to develop textile materials with potential for use in the treatment of first-degree burn injuries by approaching the hydrogels based on xanthan gum and collagen as polymeric matrix loaded with essential oils (cinnamon essential oil, tea tree essential oil), propolis (hydroglyceric extract or with content of colloidal silver) and drugs (chlorhexidine, ciprofloxacin). A total of six experimental variants of hydrogels were synthesized and then were applied by padding method on a plain weave textile structure from 100% cotton. The functionalized textile materials were characterized by morphological and antibacterial point of view. The textile materials treated materials with all synthesized hydrogels based on xanthan and collagen as polymeric matrices have antibacterial activity against S. aureus and E. coli test strains, the highest inhibition zone was provided by the samples loaded with ciprofloxacin (MUP3 and MUP4 code).

Gheorghita, Roxana, Roxana Filip, and Anderi Lobiuc. "NOVEL MATERIALS WITH MICROENCAPSULATED ESSENTIAL OILS, POTENTIAL APPLICATIONS FOR SKIN CELLULAR REGENERATION DRESSINGS." In 23rd SGEM International Multidisciplinary Scientific GeoConference 2023. STEF92 Technology, 2023. http://dx.doi.org/10.5593/sgem2023v/6.2/s24.60.

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Biopolymers have gained notoriety due to their unique physical, chemical, and mechanical characteristics and performances. Due to their regenerability, compostability, biocompatibility, non-immunogenic, non-toxic, or non-allergenic properties, they have surpassed the boundaries of the food industry and have become fundamental components in biomedicine or the pharmaceutical industry. Thus, the most well-known applications are as drug delivery systems, tissue engineering, or wound dressings. In addition to all these characteristics, biopolymeric films have proven to be excellent matrices for incorporating various biologically active substances: natural compounds, essential oils, antioxidants, etc. The present study aimed to develop sodium alginate films, with the addition of tea tree and chamomile essential oils capsules. After development through the casting method, the materials were tested for evaluate the physical properties (thickness, retraction ratio, color, transparency, opacity), chemical properties (antioxidant characteristics), mechanical properties (tensile strength and elongation), as well as solubility (water activity index, swelling index, water absorption capacity). The results indicated that alginate based - materials with the addition of essential oils capsules can be used in the pharmaceutical and cosmetic industries for developing films with regenerative properties. Similarly, other biologically active substances can be incorporated, and the development technology can be easily scaled up to an industrial level.

Mason, J. A., W. Hage, R. Price, A. C. Tolchard, and A. C. N. Towner. "An Automated Non-Destructive Assay System for the Measurement and Characterization of Radioactive Waste." In ASME 2003 9th International Conference on Radioactive Waste Management and Environmental Remediation. ASMEDC, 2003. http://dx.doi.org/10.1115/icem2003-4654.

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The paper describes an automated non-destructive assay (NDA) system for the measurement and characterization of radioactive waste. The Waste Characterisation System (WCS) can be adapted to measure a variety of drum sizes: 60, 220 (55 gallon) and 440 liter, the latter with a maximum weight of 1500 kg (1.5 tonnes). The NDA system includes a Tomographic Segmented Gamma Scanner (TSGS) and an active/passive neutron Differential Die-away (DDA or DDT). The system can assay a wide variety of waste types in a range of waste matrices. The assay stations are linked by a heavy duty roller conveyor which incorporates a 20 drum buffer store, a load cell (built into the conveyor), bar code readers and a dose rate measurement station. The Tomographic Segmented Gamma Scanner (TSGS) combines conventional high resolution gamma spectrometry and a tranission source to interrogate a waste drum in vertical slices (segments) as for Segmented Gamma Scanner (SGS) measurements. However, in the case of the TSGS, while the drum is rotated, it is also moved in the horizontal direction leading to an enhanced ability to correct the gamma ray energies, from the nuclides of interest, for the attenuation of the matrix. The TSGS can also be operated as a conventional SGS for the measurement of homogeneous waste drums. The DDA is a very sensitive active neutron interrogation method that uses thermalised neutrons from a pulsed source within the chamber to irradiate a waste drum. Prompt neutrons from fissile material present in the waste (e. g. 239Pu, 235U) are detected and provide a measure of the fissile content in the drum. In passive mode, the DDA determines the even Pu nuclides exhibiting significant spontaneous fission (e.g. 240Pu). Measurement accuracy depends on correction algorithms to compensate for self-shielding and matrix effects in waste drums containing hydrogenous materials. In addition, the DDA will be provided with the Fission-Fission Neutron Correlation Analysis System (FFnC) which is an absolute technique eliminating the need for matrix dependent mass calibrations, and allowing separate U and Pu determination using delayed neutron counting. The FFnC technique will be tested for the first time on the WCS. The NDA system incorporates integrated stations to determine the weight and dose rate of each drum, the former built into the conveyor the latter as part of the TSGS. Six Geiger Muller tubes measure the surface dose at three positions on the drum side, one at 1 metre from the drum and one each measuring the surface dose of the top and bottom of the drum. The assay instruments are linked to a heavy duty conveyor system onto which up to 20 waste drums can be loaded for delivery to the various measurement stations, thus permitting unattended, automated operation. Once measured, the drums remain on the conveyer in a holding system waiting to be unloaded. Automation is provided using a programmable logic controller (PLC) and associated computers. A central computer and associated software is used for data acquisition and management.