Дисертації з теми "Drug Delivery Applications"
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Banerjee, Abhishek. "Functionalizable Biodegradable Polyesters for Drug Delivery Applications." University of Akron / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=akron1335240206.
Повний текст джерелаTamames, Tabar Cristina. "Metal-organic frameworks for drug delivery applications." Thesis, Versailles-St Quentin en Yvelines, 2014. http://www.theses.fr/2014VERS0006/document.
Повний текст джерелаIn this work, a new type of particles denoted as MOFs or Metal-Organic Frameworks, havebeen studied as a new drug carriers.First, they were synthesised at the nanoscale (NPs) using, when possible, biofriendlymethods. Their cytotoxicity, as well as that from their constitutive linkers, was evaluatedby the MTT test in murine macrophage (J774) and in cervix carcinoma (HeLa) cell lines,observing: (i) a low cytotoxicity of MOFs, comparable with other described particulatedsystems, (ii) a strong influence of the composition (toxicity order: Fe
En este trabajo, se han estudiado un nuevo tipo de partículas denominadas MOFs oMetal-Organic Frameworks como transportadores de fármacos.Primero, se sintetizaron en escala nanométrica (NP) sustituyendo los disolventes tóxicoscuando fuese posible. Se evaluó su citotoxicidad, así como la de sus ligandos, mediante eltest de MTT en las líneas celulares J774 (macrófagos murinos) y en HeLa (carcinoma decérvix), observando: (i) una baja citotoxicidad de los MOFs, comparable a otros sistemasparticulados, (ii) una fuerte influencia de su composición (orden de toxicidad: Fe
Frost, S. J. "Analytical applications of liposomes." Thesis, University of Surrey, 1994. http://epubs.surrey.ac.uk/2745/.
Повний текст джерелаOstroha, Jamie L. Lowman Anthony M. Dan Nily. "PEG-based degradable networks for drug delivery applications /." Philadelphia, Pa. : Drexel University, 2006. http://dspace.library.drexel.edu/handle/1860%20/842.
Повний текст джерелаKumar, Dhiraj. "Co-Functionalised Gold Nanoparticles for Drug Delivery Applications." Thesis, Ulster University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.649271.
Повний текст джерелаBenzeval, Ian. "Development of responsive polymers for drug delivery applications." Thesis, University of Bath, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500696.
Повний текст джерелаMitragotri, Samir. "Ultrasound-mediated transdermal drug delivery : mechanisms and applications." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/11263.
Повний текст джерелаGreen, Da'Sean Edward. "Trehalose-Stabilized Polymer Assemblies for Drug Delivery Applications." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu150332742091042.
Повний текст джерелаRoberts, Rose A. "Polymer Nanoparticle Characterization and Applications for Drug Delivery." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/104384.
Повний текст джерелаPHD
Datt, Ashish. "Applications of mesoporous silica and zeolites for drug delivery." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3442.
Повний текст джерелаCrampton, Hannah Louise. "Synthesis and characterization of melamine-based dendrimers with potential biological applications." Thesis, [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2673.
Повний текст джерелаPrausnitz, Mark R. "Electroporation of tissue and cells for drug delivery applications." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/32647.
Повний текст джерелаMa, Hui. "Nanomaterials for Biological Applications: Drug Delivery and Bio-sensing." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/td/1647.
Повний текст джерелаMarks, Joyann Audrene. "Synthesis and Applications of Cellulose Derivatives for Drug Delivery." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/75307.
Повний текст джерелаPh. D.
Twyman, Lance James. "The synthesis and applications of dentrimeric molecules." Thesis, University of Kent, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259718.
Повний текст джерелаChang, Kai. "Structural modification of poly(n-isopropylacrylamide) for drug delivery applications." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/48947.
Повний текст джерелаDe, Cecco Flavia. "Supramolecular polyelectrolyte complexes as mucoadhesive systems for drug delivery applications." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13393/.
Повний текст джерелаBergstrand, Nill. "Liposomes for Drug Delivery : from Physico-chemical Studies to Applications." Doctoral thesis, Uppsala University, Department of Physical Chemistry, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3390.
Повний текст джерелаPhysico-chemical characterisation of structure and stability of liposomes intended for drug delivery is the central issue in this thesis. In addition, targeted liposomes to be used in boron neutron capture therapy (BNCT) were developed.
Lysolipids and fatty acids are products formed upon hydrolysis of PC-lipids. The aggregate structure formed upon mixing lysolipids, fatty acids and EPC were characterised by means of cryo-TEM. A relatively monodisperse population of unilamellar liposomes was detected in mixtures containing equimolar concentration of the three components.
The interactions between alternative steric stabilisers (PEO-PPO-PEO copolymers) and conventional PC-and pH-sensitive PE-liposomes were investigated. Whereas the PE-liposomes could be stabilised by the PEO-PPO-PEO copolymers, the PC-liposomes showed an enhanced permeability concomitant with the PEO-PPO-PEO adsorption.
Permeability effects induced by different PEG-stabilisers on EPC liposomes were shown to be dependent on the length of the PEG chain but also on the linkage used to connect the PEG polymer with the hydrophobic membrane anchor.
An efficient drug delivery requires, in most cases, an accumulation of the drug in the cell cytoplasm. The mechanism behind cytosolic drug delivery from pH-sensitive liposomes was investigated. The results suggest that a destabilisation of the endosome membrane, due to an incorporation of non-lamellar forming lipids, may allow the drug to be released.
Furthermore, sterically stabilised liposomes intended for targeted BNCT have been characterised and optimised concerning loading and retention of boronated drugs.
Fach, Lars Matthias [Verfasser]. "Protein-based nanoparticles for drug delivery applications / Lars Matthias Fach." Mainz : Universitätsbibliothek Mainz, 2018. http://d-nb.info/116056146X/34.
Повний текст джерелаChowdhury, D. F. "Development of artificial carbon nanotube vesicles for drug delivery applications." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543555.
Повний текст джерелаDavidson, Scott. "Bio-inspired silica : development for drug delivery applications and biocompatibility." Thesis, University of Strathclyde, 2016. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=27559.
Повний текст джерелаDeshmukh, Ameya. "MMP-Degradable Biosensors: Applications in Drug Delivery and Personalized Medicine." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1585925271421393.
Повний текст джерелаRodriguez, Lidia Betsabe. "Controlled Release System for Localized and Sustained Drug Delivery Applications." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1365107103.
Повний текст джерелаMehta, Ankit N. "Tampon-like Foam Structures for Bioresponsive Vaginal Drug Delivery Applications." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396522494.
Повний текст джерелаYan, Huan. "MICRO- AND NANO-MATERIALS FOR DRUG DELIVERY AND BIOIMAGING APPLICATIONS." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1428155172.
Повний текст джерелаKakde, Deepak. "Synthesis, characterisation and applications of new polyesters for drug delivery." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/37381/.
Повний текст джерелаSteiert, Elena [Verfasser]. "Dynamic Protein-based Nanoparticles for Drug Delivery Applications / Elena Steiert." Mainz : Universitätsbibliothek Mainz, 2020. http://d-nb.info/1205821899/34.
Повний текст джерелаLee, Ryan Thomas. "Modulation of Keratin Biomaterial Formulations for Controlled Mechanical Properties, Drug Delivery, and Cell Delivery Applications." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1385549579.
Повний текст джерелаHilder, Tamsyn A. "Modelling nanostructures as nano-oscillators for applications in nanomedicine." Access electronically, 2008. http://www.library.uow.edu.au/adt-NWU/public/adt-NWU20080918.101103/index.html.
Повний текст джерелаMazumder, Sonal. "Synthesis and Characterization of Drug-Containing, Polysaccharide-Based Nanoparticles for Applications in Oral Drug Delivery." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/23692.
Повний текст джерелаThe purpose of this research was two-fold. First, the methodology for producing drug-polymer nanoparticles with well-defined particle size distributions was developed. Second, the factors affecting drug loading and release properties of these nanoparticles were investigated. The nanoparticles were processed using two methods of solvent removal and drying to investigate their effects on drug loading and particle size: (a) various combinations of rotary vacuum evaporation (rotavap) and acid-induced flocculation were used and (b), dialysis followed by freeze drying. Dynamic light scattering showed particle sizes were between 150-400 nm with polydispersity index values as low as 0.12. The antibiotic drug loading efficiencies ranged from 14-40%, whereas drug loading efficiency as high as 85 % was attained with the antiviral drug. The dissolution studies showed an increase in the solution concentration and release of the amorphous drug nanoparticles. The high glass transition temperature helped to stabilize the drug in an amorphous form, thus increasing the effective solution concentration of the drug in an aqueous medium.
Ph. D.
Cheung, Wai-Han. "Novel steroidal metal complexes with potential pharmaceutical applications." Thesis, Loughborough University, 1992. https://dspace.lboro.ac.uk/2134/27879.
Повний текст джерелаLeonard, Alex. "Elastin Like Polypeptides as Drug Delivery Vehicles in Regenerative Medicine Applications." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/5981.
Повний текст джерелаKulkarni, Harsha Prabhakar Wu Yue. "Synthesis and applications of titania nanotubes drug delivery and ionomer composites /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1649.
Повний текст джерелаTitle from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum in Applied and Materials Sciences." Discipline: Applied and Materials Sciences; Department/School: Applied and Materials Sciences.
Konhäuser, Matthias [Verfasser]. "Dynamic Polysaccharide-based Nanoparticles for Advanced Drug Delivery Applications / Matthias Konhäuser." Mainz : Universitätsbibliothek Mainz, 2020. http://d-nb.info/1202851681/34.
Повний текст джерелаWilliamson, Matthew R. "Novel biodegradable fibres for applications in tissue engineering and drug delivery." Thesis, Aston University, 2003. http://publications.aston.ac.uk/11000/.
Повний текст джерелаAngelos, Sarah Ann. "Molecular machines supported on mesoporous silica nanoparticles for drug delivery applications." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1835827851&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Повний текст джерелаMäe, Maarja. "Rational modifications of cell-penetrating peptides for drug delivery : Applications in tumor targeting and oligonucleotide delivery." Doctoral thesis, Stockholms universitet, Institutionen för neurokemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8374.
Повний текст джерелаLin, Wan-Hua. "Cellulose Aerogel Monoliths and Microparticles and Their Applications in Drug Delivery System." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1515433467041194.
Повний текст джерелаChoi, Sungmoon. "Fluorescent noble metal nanodots for biological applications." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37195.
Повний текст джерелаHelfrich, Marcus Robert. "Preliminary investigations into the development of novel layered phosphonic acid vesicles for targeted drug delivery applications /." view abstract or download file of text, 2002. http://wwwlib.umi.com/cr/uoregon/fullcit?p3045088.
Повний текст джерелаTypescript. Includes vita and abstract. Includes bibliographical references (leaves 184-193). Also available for download via the World Wide Web; free to University of Oregon users. Address: http://wwwlib.umi.com/cr/uoregon/fullcit?p3045088.
Engstrand, Johanna. "Designing star-like block-copolymers as compartmentalized nanostructures for drug delivery applications." Thesis, Uppsala University, Department of Materials Chemistry, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-119971.
Повний текст джерелаThis thesis describes syntheses and characterization of star-like amphiphilic block copolymers consisting of poly(ethylene glycol) (PEG) as the hydrophilic block,polycarbonate as the hydrophobic block and an amine-containing dendrimer as the core molecule. The macromolecules were synthesized by either a convergent or adivergent approach that includes tandem click reactions and ring opening polymerizations (ROP) of methyl trimethyl carbonates (MTC) with differentfunctionalities. The ROP of MTC monomers was performed using organocatalysts that allow mild reaction condition and reasonable molecular weight distribution(PDI~1.3). These synthetic approaches provide the resultant polymers with three different conformations, which are; mikto-arm type, comb-block with short PEGbrushes, and linear block with long PEG chain. The star-like polymers that were synthesized were all water soluble and most of them formed nano aggregates inwater. Different morphologies were observed in AFM study depending on the polymer conformation. Interestingly, some of them had indications pointing towards alower critical solution temperature.
Perelman, Loren Avery. "Macromolecular coatings on porous silicon applications in drug delivery, biosensing, and composites /." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3290779.
Повний текст джерелаTitle from first page of PDF file (viewed February 5, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
Argyo, Christian. "Tailoring properties of multifunctional Mesoporous Silica nanoparticles for controlled drug delivery applications." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-183268.
Повний текст джерелаHasan, Mohammad Nazmul. "Developing Glycopeptide based nanocarriers by ring opening polymerization for drug delivery applications." Thesis, Uppsala universitet, Institutionen för kemi - Ångström, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233891.
Повний текст джерелаMadeira, do Ó. João. "Applications of glycopolymer libraries as protein aggregation modulators and drug delivery systems." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/38014/.
Повний текст джерелаEdward, Jonathan M. (Jonathan Mark). "Commercial potential for thermal & magnetic sensitive polymer in drug delivery applications." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45958.
Повний текст джерелаIncludes bibliographical references (leaves 75-80).
Thermal and magnetically sensitive polymers are a new class of materials with unique properties suitable for applications in drug delivery. Specifically, these polymers can be combined with a drug reservoir to make a drug delivery device that can be triggered externally. Such a device could be implanted subcutaneously and allow for temporal control of drug release and localized delivery. Current experiments have shown that a prototype device is capable of delivering both small and large molecule drugs. Attractive medical applications for this technology were discovered and their respective markets examined. Additionally, the scientific literature and intellectual property in this field were analyzed for competing technologies that would hinder development of this invention. Novel attributes of this technology were also identified and specific competitive advantages made evident. To facilitate the commercialization of this novel technology, a business model has been proposed that identifies possible risks and provides strategies for overcoming them. Using this model, a timeline for future research and development has been constructed that traces the technology from its current state to a final product that can be launched commercially. The requirements for regulatory approval have also been investigated and a plausible manufacturing process has been established. Furthermore, a cost model and pricing analysis has been conducted to determine if a viable business proposition around this technology can be made.
by Jonathan M. Edward.
M.Eng.
Helm, Eric. "Solute Partitioning in Elastin-like Polypeptides: A Foundation for Drug Delivery Applications." Cleveland State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=csu1450790146.
Повний текст джерелаWen, Amy M. "Engineering Virus-Based Nanoparticles for Applications in Drug Delivery, Imaging, and Biotechnology." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1452954511.
Повний текст джерелаFenn, Spencer Lincoln. "Seaweed to Sealant : Multifunctional Polysaccharides for Regenerative Medicine and Drug Delivery Applications." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/697.
Повний текст джерелаFan, Dongmei. "Mesoporous silicon/biopolymer composities for orthopedic tissue engineering and drug delivery applications." [Fort Worth, Tex.] : Texas Christian University, 2008. http://etd.tcu.edu/etdfiles/available/etd-12192008-090502/unrestricted/fan.pdf.
Повний текст джерела