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Дисертації з теми "Drosophila Genetics"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 січня 2023

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1

Nicholls, Felicity K. M. "Genetic analysis of the gene Additional sex combs and interacting loci." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29644.

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In order to recover new mutant alleles of the Polycomb group gene Additional sex combs (Asx), mutagenized chromosomes were screened over the putative Asx allele XT129. Thirteen new mutant strains that fail to complement XT129 were recovered. Unexpectedly, the thirteen strains sorted into four complementation groups. Recombination mapping suggests that each complementation group represents a separate locus. The largest group fails to complement a deletion of Asx and maps in the vicinity of 2-72, the published location of Asx. All new mutant strains enhance the phenotype of Polycomb mutant flies

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2

O'Keefe, Louise. "Genetic analysis of the role of pebble during cytokinesis in Drosophila." Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09pho415.pdf.

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Errata pasted onto back page. Bibliography: p. 133-149. The RhoGEF activity of PBL is shown to be acting predominantly by the activation of Rho1 and downstream signaling pathways required for contractile ring function during cytokinesis. Genetic evidence suggests this could be through the activation of Diaphanous (an FH protein) to reorganize the actin cytoskeleton, as well as through the activation of Rho-kinase which results in the phosphorylation, and activation of myosin. Highlights a possible role for PBL during contractile ring function at a later stage that previously thought. Genetic

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3

Riddihough, Guy. "The Drosophila hsp27 promoter." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258159.

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4

Johnstone, Oona. "Characterization of the Vasa-eIF5B interaction during Drosophila development." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84265.

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Translational control is an important means of regulating gene expression. Development of the Drosophila germ line relies on translational regulation to differentially express maternal mRNAs, allowing it to develop distinctly from the soma. One of the critical factors required for germ cell development and function is the conserved DEAD-box RNA helicase Vasa (Vas). The research presented in this thesis examines the role of Vas in translational regulation during Drosophila germ line development. A two-hybrid screen conducted with Vas identified a translation initiation factor eIF5B (dIF2

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5

Zhang, Li. "DRMT4 (Drosophila arginine methyltransferase 4) : functions in Drosophila oogenesis." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80905.

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DRMT4 (Drosophila Arginine MethylTransferase 4) is an arginine methyltransferase in Drosophila (Boulanger et al. 2004). It shows the highest identities with mammalian PRMT4/CARM1 (Protein Arginine MethylTransferase 4) (59% identity, 75% similarity). HPLC analysis demonstrated that DRMT4 belongs to the type I class of methyltransferases (Boulanger et al. 2004), meaning that DRMT4 catalyzes asymmetrical dimethylarginine formation. A polyclonal antibody against DRMT4 was generated and used to study DRMT4 expression using western blots and immunostainings. In order to study DRMT4 function

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6

Lee, Michael James. "TACC proteins in Drosophila and Xenopus." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619794.

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7

McGurk, Leeane. "Drosophila lacking RNA editing." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/2695.

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ADAR is an adenosine deaminase that acts on dsRNA. Once bound to dsRNA, ADAR deaminates specific adenosines into inosines. If this occurs within the coding region of a transcript the inosine will be read as a guanosine. This can lead to a change in the amino acid at this position and increase protein diversity. In mammals there are three ADAR genes: ADAR1, ADAR2 and ADAR3. However, only ADAR1 and ADAR2 have been shown to be enzymatically active. ADAR1 is widely expressed and can edit both coding RNA and non-coding RNA. ADAR2 is restricted to the CNS and the key transcript that it edits encodes

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8

Ometto, Lino. "The selective and demographic history of Drosophila melanogaster." Diss., [S.l.] : [s.n.], 2006. http://edoc.ub.uni-muenchen.de/archive/00004942.

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9

Vermeulen, Cornelis Joseph. "Genetics of lifespan determination in Drosophila melanogaster /." [Wageningen] : Ponsen & Looyen, 2004. http://www.gbv.de/dms/goettingen/473006952.pdf.

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10

Gilchrist, Anthony Stuart. "Sperm displacement in drosophila melanogaster." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263252.

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11

Harbison, Diane T. "Male-specific transcripts from Drosophila melanogaster." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337508.

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12

Von, Dassow George Robert Hartmann. "How dynamic networks animate living embryos /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/5237.

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13

O'Connell, Sinead. "Functional characterisation of the Polycomblike protein of Drosophila melanogaster." Title page, table of contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09pho1841.pdf.

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14

Garrido, Damien. "Etude de l’homéostasie lipidique chez Drosophila melanogaster." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS030.

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Le métabolisme des acides gras (AG) est crucial dans le maintien de l’homéostasie. Son implication dans des processus tels que la signalisation, le stockage énergétique, l’isolation thermique, la régulation du comportement ne révèle qu’une fraction de la complexité et de la variabilité des rôles dans lesquels il peut être associé. En outre, ce métabolisme est dérégulé dans de nombreuses pathologies, diabète, obésité, cancers,... C’est pourquoi les enzymes de ce métabolisme constituent des cibles attractives pour développer de nouveaux traitements. Cependant les conséquences de ces dérégulation

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15

Ayyar, Savita. "Analysis of TGIF function in Drosophila." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620360.

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16

Wang, Shu-Huei. "Regulation of vein, an activating ligand of the drosophila EGF receptor." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1054165285.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xv, 189 p.; also includes graphics (some col.) Includes bibliographical references (p. 168-189). Available online via OhioLINK's ETD Center

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17

Gould, Alexander Paul. "Homeotic gene function during embryogenesis in Drosophila." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335101.

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18

Hemmat, Mortaza. "Genetic analysis of competition in Drosophila melanogaster." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257181.

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19

Tauber, Merav. "Molecular genetics of aggressive behaviour in Drosophila melanogaster." Thesis, University of Leicester, 2010. http://hdl.handle.net/2381/10224.

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Aggression is a key component of the normal repertoire of behaviours in a broad range of animals from insects to mammals. Although the genetic basis for aggression is widely accepted, only a few individual candidate genes have been studied. Recent studies have indicated that Drosophila melanogaster can serve as a powerful model system to study the genetics of aggression. The aim of this project was to identify genes associated with aggression by global profiling of the fly transcriptome using DNA expression microarrays. At the core of this study was a behavioural screen in which the aggression

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20

Palmer, William Hunt. "Evolution and genetics of antiviral immunity in Drosophila." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31557.

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Virus-host interactions determine virus transmissibility and virulence, and underlie coevolution that shapes interesting biological phenomena such as the genetic architecture of host resistance and host range. Characterization of the virus factors that exert selective pressure on the host, and the host genes which underlie resistance and adaptation against viruses will help to define the mechanistic pathways embroiled in host-virus coevolution. In this thesis, I describe the viral causes and host consequences of host-virus coevolution. These include genomic signatures consistent with antagonis

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21

Brown, Elizabeth. "The Behavioral Genetics of Olfaction in Drosophila melanogaster." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490351166817714.

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22

Sun, Qi Zinn Kai George. "Molecular genetics of axon guidance in Drosophila melanogaster /." Diss., Pasadena, Calif. : California Institute of Technology, 2000. http://resolver.caltech.edu/CaltechETD:etd-03242005-130557.

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23

Jud, Molly Christine. "Jun signaling during Drosophila development." Thesis, The University of Utah, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10130207.

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<p> Jun N-terminal kinase (JNK) signaling is a key modulator of development and disease in all multicellular organisms. One process in which the consequences of both gain and loss of JNK signaling can be monitored is embryonic dorsal closure (DC) in the fruit fly, <i>Drosophila melanogaster.</i> DC occurs midway through embryogenesis; it is the process by which the lateral epidermis expands bilaterally to meet and fuse at the dorsal midline, thereby encasing the entire embryo in epidermis. JNK signaling in leading edge (LE) cells (the dorsal-most row of epidermis) initiates closure. My studies

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24

Aradhya, Rajaguru. "Characterization of quiescent state and reactivation of adult muscle precursor cells in Drosophila melanogaster." Thesis, Clermont-Ferrand 1, 2013. http://www.theses.fr/2013CLF1MM16.

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Pas de résumé disponible<br>Use of stem cells in regenerative medicine has attracted great interest in the past decade. Muscle stem cells such as satellite cells were shown to regenerate skeletal muscle tissue after injury and to contribute to muscle growth. These properties have raised an enormous interest in using satellite cells for the therapy of skeletal muscle wasting disorders where the intrinsic stem cell population is unable to repair muscle tissue. However, better understanding of the mechanisms controlling satellite cell lineage progression and self-renewal is crucial to exploit the

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25

Zecchini, Vincent. "A novel function of Notch regulates JNK activity and apoptosis in the Drosophila embryo." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621033.

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26

Shen, Shih-Pei. "Characterisation of Dichaete functions and targets during Drosophila embryonic development." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612743.

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27

Coulson, Michelle R. "Characterisation of starvin' : a novel Drosophila melanogaster gene." Title page, abstract and contents only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phc855.pdf.

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Bibliography: p. 133-141. A genetic and molecular characterisation of the Drosophila gene starvin', focussing on analysis of the sequence of starvin', characterisation of the embryonic localisation of starvin' protein, and the identification and phenotypic characterisation of starvin' mutants.

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28

Łada, Karolina. "Tissue interactions and morphogenesis during Drosophila dorsal closure." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611646.

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29

Liang, Lu. "Vasa function in Drosophila pole plasm." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42079.

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Pole plasm in Drosophila melanogaster, through the posteriorly localized determinant nanos, controls the formation of the abdominal segments and, through an unknown mechanism, controls the formation of the germline. oskor, vasa, and tudor are three critical genes in the pole plasm assembly pathway and their gene products, oskar RNA, Vasa protein and Tudor protein are localized in the pole plasm in a precise order. The localization of oskar and nanos mRNAs is closely related to their translational activation. We provide evidence here by in vitro biochemical assays that Vasa protein is an ATP-de

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30

Peel, Nina. "Control of the centrosome cycle in Drosophila." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612903.

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31

Aspland, Simon Eric. "Extradenticle and HOX gene function in Drosophila." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627253.

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32

Nanda, Shreeya. "Functional characterisation of the Drosophila Sox100B gene." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614283.

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33

Boisclair, Lachance Jean-François. "Mechanisms of epithelial patterning in the «Drosophila» ovary." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=96966.

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Patterning of the Drosophila eggshell requires the induction of dorsal fates in the follicular epithelium of the ovary, which will secrete this eggshell. These fates are induced by the localized activation of epidermal growth factor (Egfr) signaling mediated by its localized ligand Gurken (Grk), which restricts the acquisition of dorsal fates to the dorsal anterior domain of the epithelium. The generation of the complex pattern of fates along the dorsal-ventral (DV) axis has been proposed to be generated by the induction of a second round of Egfr signaling in the follicular epithelium by the l

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34

Jacinto, Antonio Alfred Coelho. "Analysis of hedgehog signalling in Drosophila melanogaster development." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313805.

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35

Standen, Graeme N. "Some aspects of genetic recombination in Drosophila melanogaster." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282210.

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36

Finlayson, Andrew. "Characterisation of phosphodiesterase 11 in Drosophila melanogaster." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1954/.

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The PDE 11 family of dual specificity phosphodiesterases was first identified in 2000, and has not been well characterised, although mutations in the gene have been linked to multiple disorders, including major depressive disorder, and cancer. DmPDE11 is a dual specificity phosphodiesterase, which shows 96% similarity with the catalytic domain of HsPDE11A, and around 40% similarity along the length of the protein. The focus of this project was to characterise this important enzyme using the model organism Drosophila melanogaster. The resources available to Drosophila researchers are unrivalled

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37

Blackney, Michael James. "Characterising the Drosophila extracellular superoxide Dismutase gene." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/179761/.

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The indiscriminate action of reactive oxygen species (ROS), if left unregulated, has long been considered contributory to a range of disease processes within the animal kingdom and is also a factor associated with ageing. Consequently modifying the molecular mechanisms that regulate ROS levels may prove therapeutic and could also positively affect longevity. One of the key components of this machinery is the superoxide dismutase (SOD) family of enzymes which regulate ROS levels by scavenging the ROS superoxide. Mammals have three distinct SOD enzymes each responsible for managing superoxide le

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38

Tixier, Vanessa. "Identification et analyse fonctionnelle de nouveaux gènes impliqués dans la myogénèse chez la drosophile : et mise en évidence d'une transition métabolique nécessaire à la différenciation musculaire." Thesis, Clermont-Ferrand 1, 2011. http://www.theses.fr/2011CLF1MM19/document.

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Il existe de nombreuses similitudes au niveau des mécanismes génétiques et moléculaires qui contrôlent les différentes étapes de la myogenèse entre la drosophile et les vertébrés. Afin de mettre en évidence de nouveaux gènes impliqués dans ce processus, nous avons sélectionné des gènes conservés au cours de l’évolution afin de tester leur rôle dans la myogenèse. Des gènes candidats conservés entre le poisson zèbre et la drosophile et exprimés dans des compartiments musculaires ont été sélectionnés in silico à partir des bases de données du poisson-zèbre (Zfin) et de la drosophile (BDGP). Ainsi

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39

Stevens, Naomi Rosalie. "The molecular regulation of centriole duplication in Drosophila." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611818.

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40

Fiúza, Ulla-Maj. "Mechanisms of regulation of notch signalling in Drosophila." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611170.

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41

McQuilton, Peter Andrew. "Identification of a neurotrophin sequence homologue in Drosophila." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615279.

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42

Sajjadi, Fereydoun G. "The sequence TNNCT modulates transcription of a Drosophila Melanogaster tRNA ₄ gene." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/27522.

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The transcription efficiency of transfer RNA genes is modulated by sequences contained in their 5'-flanking region. For a tRNA val₄ gene a pentanucleotide with the sequence TCGCT was identified between positions -33 and -38. I have previously proposed that this sequence may be involved in specifically determining the rate of transcription of this gene. A general form of this sequence, TNNCT was found associated with other Drosophila tRNA genes which showed high ill vitro transcription efficiency. To further elucidate the role of TCGCT in tRNA transcription, single and double base-pair change

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43

Sambandan, Deepa. "The Genetic Architecture of odor-guided behavior in Drosophila melanogaster." NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-06032008-131124/.

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Understanding the genetic architecture of complex traits requires identification of the underlying genes and characterization of gene-by-gene and genotype by environment interactions (GEI). Behaviors that mediate interactions between organisms and their environment are complex traits that are especially sensitive to environmental conditions. Drosophila melanogaster presents an opportunity to systematically dissect epistasis and GEI, since large numbers of genetically identical individuals can be reared under defined environmental conditions. The olfactory system of Drosophila and its behaviora

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44

Shuford, David Tice Jr. "THE GENETIC ANALYSIS OF NEGATIVE GEOTAXIS BEHAVIOR IN DROSOPHILA MELANOGASTER." NCSU, 2004. http://www.lib.ncsu.edu/theses/available/etd-12082004-160325/.

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Behaviors are complex traits, which exhibit continuous phenotypic variation in natural populations. The continuous variation is attributable to the segregation of multiple interacting loci with individually small effects on behavior, which are sensitive to the environment. In Drosophila, loci with small, environmentally sensitive effects on behavior can be identified by screening collections of P-element insertions that have been generated in a co-isogenic background. Here, we have used this approach to identify novel candidate genes affecting geotaxis. Drosophila melanogaster are negatively g

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45

Shannon, Roger. "Predictive adaptive responses in Drosophila melanogaster." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/338975/.

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Predictive Adaptive Responses are changes in development made in the perinatal period in response to maternally transmitted information, and a mismatch between the diet selected during human evolution and the contemporary Western diet can produce an adult phenotype characterised by weight gain, cardiovascular disease, hypertension and diabetes. In humans, most evidence is epidemiological. Using Drosophila melanogaster, the problem can be approached from an adaptive phenotypic plasticity perspective. Health effects in humans stem from predictive adaptations made to enhance fitness and so it mus

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46

Carneiro, da Silva Joana Servulo Correia. "Population genetics of P transposable elements and their host species, with emphasis on Drosophila willistoni and Drosophila sturtevanti." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/284221.

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The evolution of the P element family was studied in members of the Drosophila willistoni and Drosophila saltans species groups (subgenus Sophophora). The transmission of P elements among species, their spread within species and the strength of selective constraints, as well as the level at which they are imposed on these elements, were investigated using DNA sequence data. Particular emphasis was placed on the evolution of the canonical P element subfamily. This subfamily includes the functional P element first isolated from Drosophila melanogaster, which was termed canonical. It includes a

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47

Loh, Samantha Hui Yong. "Molecular and genetic characterisation of Drosophila Sox50E and Sox100B." Thesis, University of Cambridge, 2000. https://www.repository.cam.ac.uk/handle/1810/251700.

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48

Knox, Andrea Lesley. "Characterisation of genes that modulate integrin function in Drosophila." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621668.

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49

SSEKIMPI, PUPULIO SSEMOMBWE NKUNA ABBY. "CHROMOSOME VARIATION IN DROSOPHILA SPECIES OF THE MULLERI COMPLEX." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183809.

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Drosophila species in mulleri complex show five rod-shaped and one pair of dot-shaped chromosome. The sex-chromosomes represent the largest pair in the female, but are heteromorphic in the male, the Y-chromosome being shorter than the X-chromosome. The purpose of the research presented here is to determine whether chromosomes in the mulleri cluster species are longer than in the mojavensis cluster. The length of X-, Y-chromosomes and the rod-like autosomes were compared among the ten species studied. All the rod-like chromosomes were measured in 30 or more brain cells in each of the ten specie

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Staller, Max V. "Measuring and Modeling Enhancers in Perturbed Drosophila Melanogaster Embryos." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226046.

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Анотація:

The diversity of animal shapes and sizes, colors and textures, or behaviors and habitats all depend on specialized cells. A newly fertilized embryo must build all these specialized cell types, a process called differentiation. Much of differentiation depends on appropriately turning genes on and off in each cell type. Cell type specific control of gene expression is encoded in a type of regulatory DNA called enhancers. I am interested in how enhancers control the cell type specific gene expression that enables specialized cell functions. Enhancers read in information from regulatory proteins

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