Дисертації з теми "Drebrin A"
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Alnafisah, Rawan Saleh Ms. "Involvement of Drebrin in Microglial Activation and Inflammation." University of Toledo Health Science Campus / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=mco1533220660007988.
Повний текст джерелаVacca, Barbara. "Régulation du trafic des protéines de la membrane apicale dans les cellules épithéliales polarisées humaines Caco-2/TC7 : Rôle du complexe Crumbs3A et de la Drebrine E2." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4069/document.
Повний текст джерелаSome serious diseases like retinal dystrophies and some cancers involve epithelial cells disorganization and the Crumbs (Crb) proteins family. The apical Crb3 (Crb3A and Cr3B isoforms) protein belongs to Crb family. The transmembrane proteins Crb have a conserved intracellular domain with common partners. It is unclear how Crb proteins are regulated by their partners and this information is required to better understand these pathologies. Here, we decided to study the apical polarity Crb3A complex (Crb3A, Pals1, PATJ) which is involved in apico-basal polarity establishment and maintenance. First, I investigated Crb3 isoforms regulation by their partners (Pals1 and PATJ). Then, I studied the regulation of apical membrane proteins, such as Crb3A, by Drebrin E2, a new partner of Crb3A which is involved in actin cytoskeleton remodeling and apical morphogenesis. During my thesis, I demonstrated: 1) the regulation of Crb3 isoforms dynamics by PATJ in Caco-2/TC7 human intestinal epithelial cells, but also, 2) a new function for Drebrin E2 in regulating the trafficking of apical membrane proteins, like DPPIV (DiPeptidyl Peptidase IV). In Drebrin E2 KD cells, apical membrane proteins expression is decreased and we observe an increased endocytosis. This leads to relocalization of the apical membrane proteins to the main degradative compartment, the lysosome. These new datas suggest a role for Drebrin E2 in the regulation of apical membrane proteins recycling pathway. The Drebrin E2 KD cells phenotype is reminiscent of the microvillar inclusions disease (MVID). Now, I am trying to investigate the link between theses pathways
Puente, Eugenia Rojas. "Turnover and localization of the actin-binding protein Drebrin in neurons." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17587.
Повний текст джерелаThis thesis studies the abundance of the protein Drebrin; DBN (Developmentally Regulated Brain Protein) in neurons, which is an actin-binding protein capable of bundling actin filaments. Synapses in the mammalian brain are formed on tiny protrusions, called dendritic spines. Changes in spine morphology affect synaptic activity and plasticity, which are processes underlying memory formation. DBN abundance plays an important role in regulating dendritic spine morphology. Cognitive decline and neurodegenerative conditions have been shown to be linked with a decrease in DBN levels. A weakening in the expression of this protein in spines is associated with the loss of synaptic connections, a common feature of ageing and neurological disorders such as Alzheimer''s disease. This evidence was the underlying motivation for studying the localization and turnover of DBN. I studied the effect of the site-specific S647 phosphorylation of DBN and found that such post-translational modification regulates protein stability. For the project, I established several novel techniques in our laboratory, including state-of-the-art methods such as FUNCAT-PLA and Puro-PLA for the visualization of de novo synthesized proteins in situ. My results show that DBN translation occurs not only in somata but also locally in the dendrites and spines. The same observation is true for DBN transcripts, which are present both in the soma and dendrites of neurons. These observations suggest that DBN could play an important role during synaptic plasticity. My results allow the future investigation of the potential role of site-specific phosphorylation of DBN in spine morphology. This PhD thesis represents a contribution to better understanding the regulation of DBN abundance. It also provides an experimental platform for additional investigation about the role of DBN in spine morphology, regarding its stability and its correlation with synaptic maintenance and function.
Hardy, Holly. "Cofilin and drebrin mediated regulation of the neuronal cytoskeleton in development and disease." Thesis, University of Exeter, 2017. http://hdl.handle.net/10871/31746.
Повний текст джерелаSonego, Martina. "The role of fascin and drebrin in neuroblast migration in the postnatal brain." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-fascin-and-drebrin-in-neuroblast-migration-in-the-postnatal-brain(2a0251cb-d86a-46f0-99ad-9f2b340b6b36).html.
Повний текст джерелаRehm, Kerstin [Verfasser], and Stefan [Akademischer Betreuer] Linder. "Drebrin preserves endothelial integrity by stabilizing nectin at adherens junctions / Kerstin Rehm. Betreuer: Stefan Linder." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2013. http://d-nb.info/1045024384/34.
Повний текст джерелаVliet, Vanessa van. "Drebrin, ein Aktin-Bindeprotein, und seine Rolle in der Zell-Zell- und Zell-Matrix-Adhäsion in humanen Endothelzellen." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-98827.
Повний текст джерелаWillmes, Claudia Gisela [Verfasser]. "Investigation of hippocampal synaptic transmission and plasticity in mice deficient in the actin-binding protein Drebrin / Claudia Gisela Willmes." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1140487078/34.
Повний текст джерелаGallrein, Christian [Verfasser]. "The actin-binding protein Drebrin and its implications for Alzheimer's Disease using the model organism C. elegans / Christian Gallrein." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1219904724/34.
Повний текст джерелаRojas, Puente Eugenia [Verfasser], Hanspeter [Gutachter] Herzel, Britta [Gutachter] Eickholt, and Matthew [Gutachter] Larkum. "Turnover and localization of the actin-binding protein Drebrin in neurons / Eugenia Rojas Puente ; Gutachter: Hanspeter Herzel, Britta Eickholt, Matthew Larkum." Berlin : Lebenswissenschaftliche Fakultät, 2016. http://d-nb.info/1113686138/34.
Повний текст джерелаButkevich, Eugenia. "Submembrane cytoskeleton-regulated assembly and functional activity of gap junctions." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972736174.
Повний текст джерелаBazellières, Elsa. "Rôle de la Drebine dans la morphogenèse épithéliale." Aix-Marseille 2, 2009. http://theses.univ-amu.fr.lama.univ-amu.fr/2009AIX22089.pdf.
Повний текст джерелаEpithelial morphogenesis is a complex process that provides a unique organization to epithelial cells in order to perform their physiological functions. Epithelial cells are highly polarized cells with an apical domain facing the outside environment and a basolateral domain contacting the underlying basal lamina. These two cell surfaces are delimited by a set of junctions providing tissue integrity and a controlled physical barrier between the outside and the inside of the body. In particular, in single layered columnar epithelia, cells are highly organized along the apico-basal axis with an apical surface that is often covered by microvilli developed to enlarge the apical surface and the exchanges with the outside medium. These microvilli in the cells are anchored in a dense actin-based network called terminal web. This cell polarity relies on the local organization of the cell cytoskeleton and the regulation of intracellular trafficking of plasma membrane components. Here we showed that Drebrin, which is an actin-binding protein, is required for the formation of the terminal web and thus for the brush border organization. In parallel, we also demonstrate a role for Drebrin in the correct distribution of endocytic and recycling vesicle during the process of cell morphogenesis
Maia, Roberta de Assis. "Screening de uma bibliotecade expressãode cDNA de cerebelo de rato usando-se como sonda o anticorpo anti-KM+ e expressão de drebinas em displasia cortical focal IIB (DCF IIB) associada com epilepsia de difícil controle medicamentoso." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/17/17140/tde-13052010-153055/.
Повний текст джерелаp83 is 83 kDa protein supposedly not yet described, nervous system specific, and developmentally regulated. p83 strongly interacts with laminin, Tau, tubulin and heat shock protein 90. It was initially detected by immunohistochemistry and western blot using an affinity-purified anti-lectin KM+ antibody. Its purification from rat brain is in progress. Identifying the involvement of p83 in human Central Nervous System processes is a required step towards understanding its biological roles. A premade cDNA rat cerebellum expression library (Lambda ZAP II, Stratagene) has been screened, using a specific antibody to isolate p83 cDNA. Anti-KM+ antibody was pre-adsorbed against E. coli XL1 Blue MRF proteins, before using in screening. Membranes were revealed by cromogenic immunodetection (alcaline fostase and NBT/BCIP). The analysis of all positive Lambda ZAP II clones was carried out by in vivo excision of pBluescript, subcloning in E. coli XL1 Blue MRF, plasmidial DNA purification and Eco RI digestion. The sequence corresponding to the clone isolated was analyzed using the NCBI tools and database. The nucleotide sequence showed identity with drebrin A and E isoforms. Drebrin A and E isoforms were detected in adults and embryos. Drebrin A is a neuron-specific, development-regulated F-actin-binding protein. It participates in growth cone extension and dendritic spine formation. Although have same drebrin and p83 properties in common, they not seem to be the same protein. We have investigated the expression of drebrin in Focal Cortical Dysplasia type IIB (FCD IIB) as compared to normal cortex. Tissue sections were stained with hematoxylin-eosin and silver (Bielchowsky). Sections were processed for immunohistochemistry using anti-drebrin antibodies M2F6 and DAS2, and an antigen retrieval technique. Detection was carried out using a biotinylated antibody, using DAB as chromogen. Dysplastic tissues (13 cases) were obtained at surgery for drug-resistant epilepsy. Controls were obtained at autopsy from 15 patients without history of neurological disorder and gross pathological changes. A specific drebrin labeling in dysplastic tissue was more intense than in controls. Indeed, most control cases exhibited at most a slightly higher staining than the background. Balloon, clear and undetermined cells, and giant, dysmorphic neurons, showed a conspicuous labeling by anti-drebrin. These cells showed a thin rim labeling of the nuclear membrane, and a finely punctate nuclear labeling. In contrast, a coarse nuclear, but a faint cytoplasm labeling was observed in autopsy cases. Our data suggest an association between Drebrin expression and the FCD IIB, a disturbance of cortical development.
Mercer, Jason C. "3,5-bistrifluoromethyl pyrazole (BTP) compounds and regulation of store-operated calcium channels by the actin binding protein drebrin." 2005. http://etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-784/index.html.
Повний текст джерелаVliet, Vanessa van [Verfasser]. "Drebrin, ein Aktin-Bindeprotein, und seine Rolle in der Zell-Zell- und Zell-Matrix-Adhäsion in humanen Endothelzellen / vorgelegt von Vanessa van Vliet." 2008. http://d-nb.info/993861873/34.
Повний текст джерелаDrebing, Benito. "Vorratsdatenspeicherung in Deutschland und Österreich: Eine Multiple Streams Analyse." Master's thesis, 2016. https://tuprints.ulb.tu-darmstadt.de/5920/1/Drebing%20Master-Thesis%202016%20Vorratsdatenspeicherung%20in%20Deutschland%20und%20%C3%96sterreich.pdf.
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