Дисертації з теми "DNN architecture"
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Azam, Md Ali. "Energy Efficient Spintronic Device for Neuromorphic Computation." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/6036.
Повний текст джерелаRiera, Villanueva Marc. "Low-power accelerators for cognitive computing." Doctoral thesis, Universitat Politècnica de Catalunya, 2020. http://hdl.handle.net/10803/669828.
Повний текст джерелаLes xarxes neuronals profundes (DNN) han aconseguit un èxit enorme en aplicacions cognitives, i són especialment eficients en problemes de classificació i presa de decisions com ara reconeixement de veu o traducció automàtica. Els dispositius mòbils depenen cada cop més de les DNNs per entendre el món. Els telèfons i rellotges intel·ligents, o fins i tot els cotxes, realitzen diàriament tasques discriminatòries com ara el reconeixement de rostres o objectes. Malgrat la popularitat creixent de les DNNs, el seu funcionament en sistemes mòbils presenta diversos reptes: proporcionar una alta precisió i rendiment amb un petit pressupost de memòria i energia. Les DNNs modernes consisteixen en milions de paràmetres que requereixen recursos computacionals i de memòria enormes i, per tant, no es poden utilitzar directament en sistemes de baixa potència amb recursos limitats. L'objectiu d'aquesta tesi és abordar aquests problemes i proposar noves solucions per tal de dissenyar acceleradors eficients per a sistemes de computació cognitiva basats en DNNs. En primer lloc, ens centrem en optimitzar la inferència de les DNNs per a aplicacions de processament de seqüències. Realitzem una anàlisi de la similitud de les entrades entre execucions consecutives de les DNNs. A continuació, proposem DISC, un accelerador que implementa una tècnica de càlcul diferencial, basat en l'alt grau de semblança de les entrades, per reutilitzar els càlculs de l'execució anterior, en lloc de computar tota la xarxa. Observem que, de mitjana, més del 60% de les entrades de qualsevol capa de les DNNs utilitzades presenten canvis menors respecte a l'execució anterior. Evitar els accessos de memòria i càlculs d'aquestes entrades comporta un estalvi d'energia del 63% de mitjana. En segon lloc, proposem optimitzar la inferència de les DNNs basades en capes FC. Primer analitzem el nombre de pesos únics per neurona d'entrada en diverses xarxes. Aprofitant optimitzacions comunes com la quantització lineal, observem un nombre molt reduït de pesos únics per entrada en diverses capes FC de DNNs modernes. A continuació, per millorar l'eficiència energètica del càlcul de les capes FC, presentem CREW, un accelerador que implementa un eficient mecanisme de reutilització de càlculs i emmagatzematge dels pesos. CREW redueix el nombre de multiplicacions i proporciona estalvis importants en l'ús de la memòria. Avaluem CREW en un conjunt divers de DNNs modernes. CREW proporciona, de mitjana, una millora en rendiment de 2,61x i un estalvi d'energia de 2,42x. En tercer lloc, proposem un mecanisme per optimitzar la inferència de les RNNs. Les cel·les de les xarxes recurrents realitzen multiplicacions element a element de les activacions de diferents comportes, sigmoides i tanh sent les funcions habituals d'activació. Realitzem una anàlisi dels valors de les funcions d'activació i mostrem que una fracció significativa està saturada cap a zero o un en un conjunto d'RNNs populars. A continuació, proposem CGPA per podar dinàmicament les activacions de les RNNs a una granularitat gruixuda. CGPA evita l'avaluació de neurones senceres cada vegada que les sortides de neurones parelles estan saturades. CGPA redueix significativament la quantitat de càlculs i accessos a la memòria, aconseguint en mitjana un 12% de millora en el rendiment i estalvi d'energia. Finalment, en l'última contribució d'aquesta tesi ens centrem en metodologies de poda estàtica de les DNNs. La poda redueix la petjada de memòria i el treball computacional mitjançant l'eliminació de connexions o neurones redundants. Tanmateix, mostrem que els esquemes de poda previs fan servir un procés iteratiu molt llarg que requereix l'entrenament de les DNNs moltes vegades per ajustar els paràmetres de poda. A continuació, proposem un esquema de poda basat en l'anàlisi de components principals i la importància relativa de les connexions de cada neurona que optimitza automàticament el DNN optimitzat en un sol tret sense necessitat de sintonitzar manualment múltiples paràmetres
Heath, Felicity. "Variable architecture polymers for DNA delivery." Thesis, University of Nottingham, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539162.
Повний текст джерелаDing, Ke. "Architectures of DNA block copolymers." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=98214217X.
Повний текст джерелаMarriott, Hannah. "Genome architecture and DNA replication in Haloferax volcanii." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/50190/.
Повний текст джерелаWei, Diming. "The beauty of DNA architecture : the design and applications in DNA nanotechnology /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?CBME%202009%20WEI.
Повний текст джерелаSchilter, David. "Synthesis and DNA-binding of Metallocyclic Architectures." Thesis, The University of Sydney, 2009. http://hdl.handle.net/2123/5317.
Повний текст джерелаSchilter, David. "Synthesis and DNA-binding of Metallocyclic Architectures." University of Sydney, 2009. http://hdl.handle.net/2123/5317.
Повний текст джерелаA new family of cationic N-heterocyclic ligand derivatives was prepared and characterised. Among these compounds are halide salts of the dications [Y(spacer)Y]2+, each of which comprise two N heterocyclic donor groups (Y = 4,4′-bipy, pyz, apyz, apym) linked by a conformationally flexible spacer such as (CH2)n, α,α′-xylylene, 2,6-lutidylene or thiabicyclo[3.3.1]nonane-2,6 diyl. The diquaternary halide salts were converted to NO3- and PF6- salts, and interaction of these bridging ligands with labile palladium(II) and platinum(II) precursors afforded several multinuclear complexes. Bis(4,4′-bipyridinium) dications were incorporated into the dinuclear macrocycles [M2(2,2′ bipy)2{4,4′ bipy(CH2)n4,4′-bipy}2]8+ (M = Pd, Pt; n = 4, 6), cis [Pd2Cl4{4,4′ bipy(CH2)34,4′-bipy}2]4+, [Pt2(dppp)2{4,4′-bipy(1,2-xylylene)4,4′-bipy}2]8+ and cis-[Pt2Cl4{4,4′-bipy(1,2-xylylene)4,4′-bipy}2]4+. While bis(pyrazinium) analogues were unreactive towards the palladium(II) and platinum(II) precursors, the doubly deprotonated bis(3 aminopyrazinium) and bis(2 aminopyrimidinium) derivatives served as charge-neutral quadruply-bridging ligands in the complexes [Pt4(2,2′ bipy)4{apyz(CH2)6apyz–2H}2]8+ and [Pt4(2,2′ bipy)4{apym(CH2)5apym–2H}2]8+, both of which feature Pt(II). Pt(II) interactions. Larger species formed when the diamine O,O′-bis(2-aminoethyl)octadeca(ethylene glycol) (PEGda) was treated with cis dinitratopalladium(II) and platinum(II) precursors. The resulting complexes [M(N,N)(PEGda)]2+ (M = Pd, Pt; N,N = 2,2′-bipy, en, tmeda) possessed great size (62 membered chelate rings) and aqueous solubility. DNA-binding studies were conducted with selected complexes in order to investigate the types of interactions these species might participate in. Equimolar mixtures containing either the 16mer duplex DNA D2 or the single strand D2a and palladium(II)/platinum(II) complexes were prepared and analysed by negative-ion ESI MS. Studies of D2/Pd(II) mixtures suggested extensive fragmentation was occuring, and the use of [Pd(tmeda)(PEGda)]2+ and [Pd2(2,2′-bipy)2{4,4′-bipy(CH2)44,4′-bipy}2]8+ resulted in D2 adducts of [Pd(tmeda)]2+ and [4,4′-bipy(CH2)44,4′-bipy]2+, respectively. Decomposition also occurred when D2a was used, although 1 : 1 adducts were observed with [Pd(tmeda)(PEGda)]2+, [Pd(2,2′ bipy)(PEGda)]2+ and [Pd2(2,2′-bipy)2{4,4′-bipy(CH2)44,4′-bipy}2]8+. The low intensities of these adducts indicated that they are unstable towards ESI MS. Analogous ESI-MS experiments using platinum(II) derivatives were performed and, in contrast to those with palladium(II), indicated that the complexes remained largely intact. ESI-MS analysis of D2/Pt(II) mixtures allowed for the detection of 1 : 1 D2 adducts of [Pt(en)(PEGda)]2+, [Pt(tmeda)(PEGda)]2+ and [Pt2(2,2′-bipy)2{4,4′-bipy(CH2)44,4′-bipy}2]8+. Intensities of the adduct ions suggested the greater charge and aryl surface area allow the dinuclear species to bind D2 most strongly. Both [Pt(2,2′-bipy)(Mebipy)2]4+ and [Pt(2,2′ bipy)(NH3)2]2+ gave rise to 1 : 2 adducts of D2, although the latter was found to be a weaker binder, perhaps owing to its lower charge. Data obtained using 1 : 5 (D2 : complex) mixtures were consistent with the results above and suggested that D2 can bind more molecules of daunomycin than any of the platinum(II) species. Analyses of D2a/Pt(II) mixtures gave results similar to those obtained with D2, although fragmentation was more pronounced, indicating that the nucleobases in D2a play more significant roles in mediating decomposition than those in D2, in which they are paired in a complementary manner. Investigations into the effects of selected platinum(II) complexes on the thermal denaturation of calf-thymus DNA (CT-DNA) in solution were conducted. Both [Pt2(2,2′ bipy)2{4,4′-bipy(CH2)64,4′-bipy}2]8+ and [Pt(2,2′-bipy)(Mebipy)2]4+ greatly stabilised CT-DNA, most likely by intercalation. In contrast, [Pt(tmeda)(PEGda)]2+ and [Pt(en)(PEGda)]2+ (as well as PEGda) caused negligible changes in melting temperature (∆Tm), suggesting that these interact weakly with CT-DNA. Data for [Pt(2,2′ bipy)(PEGda)]2+ and [Pt(2,2′-bipy)(NH3)2]2+ indicated that these species perhaps intercalate CT-DNA, with similar ∆Tm values for both complexes implying that PEGda does not play a major role in binding. While findings from ESI-MS experiments were similar to those from the thermal denaturation experiments, discrepancies between results from the two methods could be found. In particular, fragmentation of cyclic species during ESI-MS caused the binding strength of the species to be underestimated when this method was employed.
Yu, Zhiling. "Interactions and architecture of human MCM proteins in vitro and in vivo /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BICH%202003%20YU.
Повний текст джерелаIncludes bibliographical references (leaves 118-137). Also available in electronic version. Access restricted to campus users.
van, der Merwe Mariè. "Enzyme architecture and flexibility affect DNA topoisomerase I function." View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/ABSTRACTS/2007-026-van_der_Merwe-Index.html.
Повний текст джерелаTitle from title page screen (viewed on July 29, 2008). Research advisor: Mary-Ann Bjornsti, Ph.D. Document formatted into pages (xiii, 175 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 161-175).
KATAM, SHRAVANTHI. "A SCALABLE ARCHITECTURE FOR HIGH SPEED DNA PATTERN MATCHING." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1021910429.
Повний текст джерелаTägil, Tomas. "Arkitekten Hans Westman : funktionalismen och den regionala särarten /." Stockholm : Arkitekturmuseet, 1996. http://catalogue.bnf.fr/ark:/12148/cb369914944.
Повний текст джерелаSchünke, Susanne. "Entwicklung in den Chorformen englischer Kirchen vom 11. bis ins 13. Jahrhundert /." Köln : Copy-Star, 1987. http://catalogue.bnf.fr/ark:/12148/cb34925133b.
Повний текст джерелаBaldock, Brandi. "Impact of Ligand Shell Architecture on Structure and Reactivity of DNA Aptamer-Linked Gold Nanoparticle Assemblies." Thesis, University of Oregon, 2016. http://hdl.handle.net/1794/20400.
Повний текст джерелаRigo, Riccardo. "The fine architecture of guanine-rich regions within oncogene promoters." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3427311.
Повний текст джерелаAgotai, Doris. "Architekturen in Zelluloid : der filmische Blick auf den Raum /." Bielefeld : Transcript, 2007. http://catalogue.bnf.fr/ark:/12148/cb410375996.
Повний текст джерелаWinter, Engelbert. "Staatliche Baupolitik und Baufürsorge in den römischen Provinzen des kaiserzeitlichen Kleinasien /." Bonn : R. Habelt, 1996. http://catalogue.bnf.fr/ark:/12148/cb37221698j.
Повний текст джерелаLückerath, Thorsten [Verfasser]. "RAFT polymerization from DNA for DNA-polymer conjugates and higher-ordered DNA-polymer architectures / Thorsten Lückerath." Ulm : Universität Ulm, 2021. http://d-nb.info/1229993983/34.
Повний текст джерелаLindberg, Marcus. "Den tredje pedagogen." Thesis, KTH, Arkitektur, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-140195.
Повний текст джерелаFilippi, Geoffrey George. "A High-Availability Architecture for the Dynamic Domain Name System." Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/32869.
Повний текст джерелаDNS, DDNS, BGP, anycast, DHCP, replication, LDAP, multi-master, high-availability, reliability
The Domain Name System (DNS) provides a mapping between host names and Internet Protocol (IP) addresses. Hosts that are configured using the Dynamic Host Configuration Protocol (DHCP) can have their assigned IP addresses updated in a Dynamic DNS (DDNS). DNS and DDNS are critical components of the Internet. Most applications use host names rather than IP addresses, allowing the underlying operating system (OS) to translate these host names to IP addresses on behalf of the application. When the DDNS service is unavailable, applications that use DNS cannot contact the hosts served by that DDNS server. Unfortunately, the current DDNS implementation cannot continue to operate under failure of a master DNS server. Although a slave DNS server can continue to translate names to addresses, new IP addresses or changes to existing IP addresses cannot be added. Therefore, those new hosts cannot be reached by the DDNS.
A new architecture is presented that eliminates this single point of failure. In this design, instead of storing resource records in a flat text file, all name servers connect to a Lightweight Directory Access Protocol (LDAP) directory to store and retrieve resource records. These directory servers replicate all resource records across each other using a multi-master replication mechanism. The DHCP servers can add records to any of the functioning DNS servers in event of an outage. In this scheme, all DNS servers use the anycast Border Gateway Protocol (BGP). This allows any of the DNS servers to answer queries sent to a single IP address. The DNS clients always use the same IP address to send queries. The routing system removes routes to non-functional name servers and delivers the request to the closest (according to network metrics) available DNS server.
This thesis also describes a concrete implementation of this system that was created to
demonstrate the viability of this solution. A reference implementation was built in a laboratory to
represent an Internet Service Provider (ISP) with three identical regions. This implementation
was built using Quagga as the BGP routing software running on a set of core routers and on each
of the DNS servers. The Berkeley Internet Name Daemon (BIND) was used as an
implementation of the DNS. The BIND Simplified Database Backend (SDB) interface was used
to allow the DNS server to store and retrieve resource records in an LDAP directory. The Fedora
Directory Server was used as a multi-master LDAP directory. DHCP service was provided by
the Internet Systems Consortium's (ISC) DHCP server.
The objectives for the design were high-availability, scalability and consistency. These
properties were analyzed using the metrics of downtime during failover, replication overhead,
and latency of replication. The downtime during failover was less than one second. The precision
of this metric was limited by the synchronization provided by the Network Time Protocol (NTP)
implementation used in the laboratory. The network traffic overhead for a three-way replication
was shown to be only 3.5 times non-replicated network traffic. The latency of replication was
also shown to be less than one second. The results show the viability of this approach and
indicate that this solution should be usable over a wide area network, serving a large number of
clients.
Master of Science
Amanshauser, Hildegund. "Untersuchungen zu den Schriften von Adolf Loos /." Wien : VWGÖ, 1985. http://catalogue.bnf.fr/ark:/12148/cb34833913g.
Повний текст джерелаFiorito, Regina. "Wohnsiedlungsarchitektur der 60er Jahre in den Vereinigten Staaten von Amerika und Deutschland : eine vergleichende Untersuchung /." Köln : Universität zu Köln, 1999. http://catalogue.bnf.fr/ark:/12148/cb37077433j.
Повний текст джерелаWienberg, Jes. "Den gotiske labyrint middelalderen og kirkerne i Danmark /." Stockholm : Almqvist & Wiksell International, 1993. http://catalog.hathitrust.org/api/volumes/oclc/29150261.html.
Повний текст джерелаLam, Yvonne Y. S. "Architecture that Binds: A Place for Weddings and Funerals for a New Society." Thesis, University of Waterloo, 2005. http://hdl.handle.net/10012/961.
Повний текст джерелаMcLaughlin, Christopher. "Assembly of 3D DNA architectures: towards minimal design and maximal function." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117027.
Повний текст джерелаL'ADN est une biomacromolécule essentielle qui sert à encoder, transmettre et exprimer l'information génétique contenue dans toutes les formes de vie. Toutefois, al'extérieur de ce contexte biologique, les propriétés uniques d'auto-assemblage, le contenu riche en information et les méthodes de synthèse chimique simples qui sont associées à l'ADN en font un matériau idéal pour résoudre certains des grands défis dans la construction à l'échelle nanométrique. Le domaine émergent de l'assemblage supramoléculaire de l'ADN présente des solutions chimiques pour la construction de nanostructures au moyen de l'ADN, en modifiant celui-ci synthétiquement avec des molécules organiques et des motifs supramoléculaires. Cette thèse examine spécifiquement comment des blocs de construction d'ADN modifiés avec des molécules synthétiques organiques, inorganiques et des polymères peuvent être conçus pour s'assembler en structures 3D bien définies et de manière efficace. Dans la 1e partie, une stratégie d'assemblage modulaire est développée. Celle-ci permet de relier des triangles d'ADN bidimensionnels préparés de façon efficace pour créer la première structure prismatique triangulaire en 3D qui peut être coordonnée en des lieux spécifiques avec des métaux de transition. Dans la 2e partie, l'introduction sélective de symétrie dans les séquences est utilisée pour à la fois simplifier la conception et pour générer un ensemble élargi de géométries d'ADN en 3D d'une manière simple et haute en rendement. Dans les 3e et 4e parties, une méthode de construction d'ADN en 3D qui assemble un nombre minimal de brins dans un rendement presque quantitatif pour donner une structure comportant un grand nombre de sections en ADN simple-brin est introduite. Comme démontré dans la 3e partie, l'hybridation spécifique de conjugués d'ADN-polymère aux sections en simple-brin de cet échafaudage d'ADN tridimensionnel permet l'assemblage efficace de cages nanostructurées d'ADN-copolymère séquencé avec une résistance améliorée aux nucléases. Dans la 4e partie, il est démontré que des cubes d'ADN en 3D non- fonctionnalisés s'accumulent efficacement dans le cytoplasme de cellules humaines du cancer du col de l'utérus (HeLa) sans l'aide d'un agent de transfection. Collectivement, ce travail développe des stratégies «économiques en ADN» pour assembler des structures d'ADN en 3D d'une manière simple et avec un excellent rendement. Ces méthodes d'assemblage jettent les bases pour l'évaluation fondamentale et l'intégration future de structures d'ADN en 3D en tant que sondes cellulaires, outils d'administration de médicaments et moyens pour aider à résoudre certains des défis auxquels sont confrontés les chercheurs en biophysique et nanosciences.
Largillière, Justine. "Architecture moléculaire et dynamique de protéines histone-like de bactérie et d’archée." Thesis, Orléans, 2020. http://www.theses.fr/2020ORLE3052.
Повний текст джерелаHU is an essential bacterial protein that is involved in many functions related to DNA. It is present as three dimers in E.coli (two homodimers and one heterodimer). If the two homodimers are mixed in vitro, they exchange their chains to spontaneously form the heterodimer. My work was to characterize, structurally and kinetically, this exchange mechanism that can be described as a second order reaction of three successive steps : from a native conformation of each homodimer into an intermediate homodimer conformation (partially unfolded and dissociated), followed by the formation of a transient tetramer (limiting step) which finally dissociates into two heterodimers. The key residues allowing the protein to switch from the native to the intermediate state has been determined. Whereas, there are buried in the native conformation, they are forming a hydrophobic patch at the surface of the intermediate one. This patch could mediate the association of the intermediate conformation in order to form the tetramer.MC1 participates in the genome organization of several archaea and in DNA transcription and cellular division through unknown mechanisms. We discuss the solution structure of a complex formed by MC1 with a strongly distorted 15 base pairs DNA. While the protein just needs to adapt slightly its conformation, the DNA undergoes a dramatic curvature and an impressive torsion. Such a V-turn conformation of the complex lead us to propose a new binding mode for the protein as a wrapper and a structural model of MC1 with a longer DNA. XR diffraction and SAXS experiments were then carried out on this new complex. Unfortunately, the structure could not be solved due to the lack of diffraction data and the SAXS data invalidated the model. These results confirm that MC1 is an atypical protein, which stabilizes multiple V-turn conformations of the DNA in a flexible and dynamic manner
Ahlgren, Sara, and Jenny Lindström. "Ekonomi, kunskap och kommunikation : – Avgörande för den estetiska kvaliteten vid nyproduktion av bostäder." Thesis, Linnéuniversitetet, Institutionen för byggteknik (BY), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-86243.
Повний текст джерелаThere are indications that the architecture in Sweden is perceived as more and more monotonous with the absence of aesthetic qualities. Architects are allowed to bear responsibility for the claim but they themselves believe that they deprived their position in the construction process where they are replaced under ongoing projects, ancillary financial interests. The goal of the work was to find out what happens to a building's aesthetic qualities when the architect is replaced and what lies behind the replacement of the architect. A comparison of two objects was made, one in which the architect has been involved throughout the process and one where the architect has been replaced. The study was conducted through fact-finding from literature, observations and interviews. The result shows that the desire to build beautifully with aesthetic qualities is strongly linked to the client's level of ambition. However, the overall result shows that aesthetic values are subordinated to the economy of the construction-process. Furthermore, it has emerged during the work with this essay that there is a lack of knowledge and difficulties in communication between the actors in the construction industry, especially between architects and contractors.
Lemaître, Charlène. "Nuclear architecture and DNA repair : double-strand breaks repair at the nuclear periphery." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ079/document.
Повний текст джерелаDNA is constantly assaulted by various damaging agents, leading to different types of lesions including double-strand breaks (DSBs). DSBs are the most harmful lesions to the cells and their inaccurate or inefficient repair can trigger genomic instability and tumorigenesis. To cope with DSBs, cells evolved several repair pathways, including non-homologous end joining (NHEJ) and homologous recombination (HR). A fine regulation of the balance between these two pathways is necessary to avoid genomic instability.All of these mechanisms happen in the nucleus, which is highly heterogeneous in mammalian cells. Indeed, it encompasses several compartments and regions of various chromatin compaction levels. My PhD project focused on the influence of nuclear architecture on DNA repair pathway choice. I demonstrated on one hand that the nuclear pore protein Nup153 influences the balance between HR and NHEJ and on the other hand that the position of a DSB influences the choice of the repair pathway that will be used.My results demonstrate that gene positioning is a new important parameter in the study of DNA repair and tumorigenesis
Good, Kristi Lauren. "The influence of DNA architecture on transcriptional activation at the interleukin-2 promoter." Diss., Connect to online resource, 2005. http://wwwlib.umi.com/cr/colorado/fullcit?p1430201.
Повний текст джерелаPiantanida, Luca. "DNA ORIGAMI ACTUATION AS A POWERFUL DYNAMIC AND TUNABLE ARCHITECTURE FOR PLASMONIC STRUCTURE." Doctoral thesis, Università degli studi di Trieste, 2015. http://hdl.handle.net/10077/11133.
Повний текст джерелаIn questa tesi presento il mio lavoro di ricerca di Dottorato in Nanotecnologie. Questo studio è concentrato sull'uso di nanotecnologia a DNA come strumento per la creazione di strutture nano-biologiche e funzionalizzazione di particelle d'oro. Le nano-particelle d'oro sono state largamente studiate e le loro proprietà sono state sfruttate per importanti applicazioni come la spettroscopia Raman, la rilevazione biologica e la terapia medica. Queste nano-particelle sono caratterizzate da una risonanza ottica plasmonica e proprietà di dispersione della luce ben definite ed esistono numerosi protocolli di provata efficienza per la loro funzionalizzazione chimica. Tra questi, il protocollo di auto-assemblaggio di DNA si è dimostrato eccellente nel comporre strutture di nano-particelle con dimensioni e forma controllate. Questo approccio è stato impiegato per l'ingegnerizzazione di proprietà ottiche, per la creazione di "hot spot” nel campo plasmonico in aggregati di nano-particelle e anche per la formazione di righelli plasmonici con dimeri di nano-particelle nei quali la loro spaziatura è controllata con precisione nanometrica. In questo studio confronto due strategie per la formazione di dimeri di nano-particelle d'oro usando l'ibridizzazione del DNA. Una di queste strategie mi ha permesso di raggiungere una al resa del 26% di formazioni di dimeri rispetto al totale delle AuNP, senza ulteriori procedure di filtrazione, dato che rappresenta il valore più alto riportato in letteratura; inoltre questo dato è stato replicato utilizzando sequenze di DNA molto corte, fino ad 11 nucleotidi, condizione che normalmente riduce l’efficienza del processo. Nella seconda parte della mia tesi, ho combinato le proprietà plasmoniche delle nano-particelle d'oro con strutture a DNA origami in modo da creare sistemi ibridi tra di loro. Questa combinazione mi ha permesso di esplorare architetture innovative per la il controllo della plasmonica con la prospettiva di essere un punto di partenza per lo sviluppo di biosensori. Ho sviluppato una strategia per un controllo innovativo, reversibile e continuo della risonanza plasmonica usando un'attuazione basata su DNA origami. Il meccanismo di attuazione è basato sull'ibridizzazione del DNA, in particolare si è visto uno spostamento del picco di risonanza fino a 6 nm utilizzando tre sequenza di DNA diverse. Il sistema proposto è potrà essere utilizzato per lo studio dei meccanismi di ibridazione di DNA in condizioni di stress controllato, oppure potrà essere usato come piattaforma per un controllo continuo della posizione della risonanza plasmonica o in spettroscopia Raman.
XXVII Ciclo
1986
Findal, Wenche. "Mellom tradisjon og modernitet : arkitekt Ove Bang og den funksjonelle syntese /." Oslo : Universitetsforlaget, 1998. http://catalogue.bnf.fr/ark:/12148/cb41127354n.
Повний текст джерелаKim, Yeonhee. "The Design and Assembly of 3D Liver Mimetic Cellular Architectures." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/39454.
Повний текст джерелаPh. D.
Rizvi, Kishwar 1965. "Transformations in early Safavid architecture : the Shrine of Shaykh Safi al-din Ishaq Ardabili in Iran (1501-1629)." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/9023.
Повний текст джерелаTanh, Jeazet Harold Brice. "Metallo-supramolecular Architectures based on Multifunctional N-Donor Ligands." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-39665.
Повний текст джерелаLee, Sally. "Architecture of RNA polymerase II and RNA polymerase III pre-initiation transcription complexes /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/9213.
Повний текст джерелаLee, Daniel Gyejun 1971. "Architecture of the Saccharomyces cerevisiae origin recognition complex bound to origins of DNA replication." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85345.
Повний текст джерелаAraki, Sumiko. "Physical Approach to Effect of Global Architecture on Higher Order Structure of DNA Chain." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/124392.
Повний текст джерелаRomedahl, Eriksson Amanda. "Den fjärde väggen." Thesis, KTH, Arkitektur, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-222133.
Повний текст джерелаAn attempt of storytelling using the tools of the architect The project is an investigation of what role storytelling could have within the field of architecture. With interactive theatre, where the audience’s choice of movement conducts the theatre experience, architecture within computer games and artificial worlds this kind of specific architecture has relevance. I have chosen to interpret the dystopian novel Kallocain by the Swedish author Karin Boye. Living today in a society permeated by fear for the unknown, false alarms and constant surveillance of citizens for their own security, the dystopia feels more relevant today than ever. The title of the project "The fourth wall" is an expression that is used in the field of theatre. It refers to the invisible wall and the silent agreement between the stage and the audience witch allows us to read representations of reality as temporary realities while watching a play. By altering the invisible wall and make it a real one the silent agreement disappears. But when stage becomes space it also affects our understanding of what I is real and what is fiction.
Chow, Brian 1978. "Photoelectromechanical synthesis of low-cost DNA microarrays." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/42405.
Повний текст джерелаIncludes bibliographical references.
Recent advances in de novo gene synthesis, library construction, and genomic selection for target sequencing using DNA from custom microarrays have demonstrated that microarrays can effectively be used as the world's cheapest sources of complex oligonucleotide pools. Unfortunately, commercial custom microarrays are expensive and not easily accessible to academic researchers, and technical challenges still exist for dealing with the small amount of DNA synthesized on a chip. Genomic research would certainly benefit from the creation of cheaper custom microarrays with larger oligonucleotide concentrations per spot. This thesis presents the development of a novel DNA microarray synthesis platform based on semiconductor photoelectrochemistry (PEC) designed with these needs in mind. An amorphous silicon photoconductor is activated by an optical projection system to create "virtual electrodes" that electrochemically generate protons in a site-selective manner, thereby cleaving acid-labile dimethoxytrityl protecting groups with the spatial selectivity that is required for in-situ DNA synthesis. This platform has the potential to be particularly low-cost since it employs standard phosphoramidite reagents, visible wavelength optics, and a cheaply microfabricated and reusable substrate. By incorporating a porous thin-film glass that dramatically increases the DNA quantity produced by over an order of magnitude per chip, this platform may also simplify the handling of DNA cleaved from chip and drive down the cost per base synthesized. The hybridization detection of single-base errors was successfully demonstrated on PEC synthesized microarrays. This thesis also reports a suite of new surface chemistries and high-resolution techniques for patterning biological molecules.
by Brian Yichiun Chow.
Ph.D.
Plontke-Lüning, Annegret. "Frühchristliche Architektur in Kaukasien : die Entwicklung des christlichen Sakralbaus in Lazika, Iberien, Armenien, Albanien und den Grenzregionen vom 4. bis zum 7. Jh. /." Wien : Verlag der Österreichischen Akademie der Wissenschaften, 2007. http://edoc-storage.obvsg.at/ce-ag/bvb/0006/007/09/BV022931106_AC06406406_n0001in.1xxxxxxxxx.pdf.
Повний текст джерелаEischeid, Mark Romley. "Dan Kiley and the artificial infinite." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25845.
Повний текст джерелаTiengwe, Calvin. "Analysis of the architecture and function of the nuclear DNA replication apparatus in Trypanosoma brucei." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/2307/.
Повний текст джерелаBoström, Helene. "Arkitektur & den kollektiva självbilden : En strävan att bevara Malungs kulturhistoriska arv." Thesis, KTH, Arkitektur, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-229760.
Повний текст джерелаThis project aims to preserve Malungs cultural heritage. A heritage of leather craftsmanship which has defined the area in centuries and has been a big part of the local identity. A heritage which today risk to be forgotten. In an attempt to bring the knowledge & traditions around the leathercraft in to the future I have created spaces where it allows to live on. I have also aimed to answer to Malungs contemporary needs. The proposal is located on a site where a factory building, who for a long time characterized Malung and were an important part of the area’s identity, earlier were situated. Due to a fire in 2014 the building burnt down and a part of the cultural identity got lost with it.
Knauff, Kristina. "Den klassicistiska vändningen i det tidiga 1900-talets svenska arkitektur : En studie av Liljevalchs konsthall, Kungstornen och Kanslihuset i Stockholm." Doctoral thesis, KTH, Arkitekturens historia och teori, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-93540.
Повний текст джерелаQC 20120424
Zigler, David Francis. "Synthesis and Study of Polyazine Bridged Mixed Metal Dyads: Electrochemical, Photophysical, and Photochemical Properties of a New Supramolecular Architecture." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/29453.
Повний текст джерелаPh. D.
Zofkova, Magdalena. "Evolutionary dynamics in ephemeral pools : inferences from genetic architecture of large branchiopods." University of Western Australia. School of Animal Biology, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0048.
Повний текст джерелаHintzen-Bohlen, Brigitte. "Herrscherrepräsentation im Hellenismus : Untersuchungen zu Weihgeschenken, Stiftungen und Ehrenmonumenten in den mutterländischen Heiligtümern Delphi, Olympia, Delos und Dodona /." Köln : Böhlau, 1992. http://catalogue.bnf.fr/ark:/12148/cb39170806h.
Повний текст джерелаWeiler, Gabriele. "Domos theiou basileos : Herrschaftsformen und Herrschaftsarchitektur in den Siedlungen der Dark Ages /." München ; Leipzig : Saur, 2001. http://catalogue.bnf.fr/ark:/12148/cb389058682.
Повний текст джерелаBeckman, Per. "Umeå Moské : En ny moské i Umeå som en del av den nya översiktsplanen för stadsdelen Ön." Thesis, KTH, Arkitektur, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-34739.
Повний текст джерелаAlmeida, Rafael Goffinet de. "Arte, Arquitetura e Cidade nas investigações de Dan Graham." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/102/102132/tde-13102016-115116/.
Повний текст джерелаThis study investigates the production of the American artist Dan Graham, focusing on the close relationship he mantained with the architecture and the city throughout his carrer. Held in very diverse mean and supports, the production of this artist is quite representative of the contemporary art development from the 1960s, marked by overcoming artistic codes that culminated in the disruption of physical boundaries behind museums and galleries. Through the interventons in magazines, performances and installations, his recent steel and glass pavilion and the extensive production of texts, Graham mobilized different contents stemmed from ields such as psychology, cinema and also the architecture to investigate the condition of art, culture and spatiality in contemporary society. By the juxtaposition of his works and his writings, which most explicity the deals with external issues to the art, it is possible to identify the articulation of Graham´s practice and thought, observing more deeply his relections on the social and cultural structures operating in speciic spatial contexts, either inside the art gallery or outside of it. At the end, it is expected that the synthesis of these isseus allow us to reveal the new perspectives built by Dan Graham on the ield of Architecture and Urbanism, pointing questions from a external and different nature: his aesthetical proposals inquire the contemporary city forms of production,especially in relation to cultural and social nature of their spaces.