Дисертації з теми "Disease cycle"
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Hong, Angela M. "Cell cycle protein expression in AIDS-related and classical Kaposi's sarcoma." Connect to full text, 2004. http://hdl.handle.net/2123/583.
Повний текст джерелаTitle from title screen (viewed 5 May 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Faculty of Medicine. Includes list of published articles and presentations. Includes bibliographical references. Also available in print form.
Uebayashi(Yoshitoshi), Elena Yukie. "Modelling urea-cycle disorder citrullinemia type 1 with disease-specific iPSCs." Kyoto University, 2017. http://hdl.handle.net/2433/227584.
Повний текст джерелаHamana, Katy. "An exploration of the physical activity life cycle in Huntington's disease." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/107624/.
Повний текст джерелаWilks, Mark. "Quantitative bacteriology of the vaginal flora in health and disease." Thesis, Queen Mary, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266015.
Повний текст джерелаRaina, Arun K. "Oncogenic Parallels in Alzheimer Disease." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1102023891.
Повний текст джерелаSmith, Maria Z. "Neuronal cell cycle regulation and the pathophysiology of Alzheimer's disease and related dementias." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393617.
Повний текст джерелаBourgeois, Chantal G. "The impact of AIDS on the life cycle of young gay men." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0022/MQ50697.pdf.
Повний текст джерелаChen, Lina. "Structural and functional studies of the cell cycle regulator RGC-32." Thesis, University of Sussex, 2017. http://sro.sussex.ac.uk/id/eprint/68451/.
Повний текст джерелаBoeras, Debrah I. "Chromosome missegregation in Alzheimer's disease caused by presenilin 1." [Tampa, Fla] : University of South Florida, 2005. http://purl.fcla.edu/usf/dc/et/SFE0001706.
Повний текст джерелаDear, Graeme. "Studies on the biology, metabolism and pathogenicity of Pseudomonas Anguilliseptica." Thesis, Heriot-Watt University, 1985. http://hdl.handle.net/10399/1599.
Повний текст джерелаBailey, Jarrod. "Analysis of the proteins involved in the life-cycle and replication of Newcastle disease virus." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264418.
Повний текст джерелаLinseman, Tara. "Functional Analysis of a Coding Variant In ZC3HC1 at 7q32.2 Associated with Protection Against Coronary Artery Disease (CAD)." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34329.
Повний текст джерелаVarvel, Nicholas H. "The role of beta-Amyloid and inflammation in neuronal cell cycle events in Alzheimer's disease mouse models." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1226609920.
Повний текст джерелаFiorelli, Tina N. "Proteolytic Processing of the Amyloid Precursor Protein During Apoptosis and Cell Cycle: Implications for Alzheimer's Disease." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4486.
Повний текст джерелаLopes, Previdelli Renato [Verfasser]. "Novel insights on viral factors involved in the Marek's Disease virus' life cycle / Renato Lopes Previdelli." Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1200409752/34.
Повний текст джерелаVan, Niekerk Elizabeth C. "Evaluation of a quality improvement cycle intervention in the provision of PMTCT at a regional hospital." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85669.
Повний текст джерелаENGLISH ABSTRACT: The vast majority of new Human Immunodeficiency Virus (HIV) infections in infants and young children occur through mother-to-child-transmission (MTCT), either during pregnancy, labour or delivery or by breastfeeding. Without access to perinatal MTCT (PMTCT) programmes approximately 30% of all babies born annually will be infected with HIV. OBJECTIVES The aim was to implement and audit a quality improvement cycle at the Worcester Obstetric Unit, which comprises of Worcester Hospital, a regional hospital in the Western Cape Province and its level one midwife obstetric Unit (MOU), in order to improve the quality of the PMTCT programme. The intervention included the implementation of easy changes and tools in the Antenatal Clinic, Infectious Diseases Clinic and Labour ward. METHODS The files and antenatal records of all HIV positive patients and patients with an unknown HIV status, who delivered at the Worcester Obstetric Unit during January, February and March of 2010 and 2011, were reviewed. All HIV negative patients and patients that had stillbirths and miscarriages were excluded. The pre-interventional findings of 2010 were compared with the post-interventional findings of 2011. RESULTS At the Worcester Obstetric Unit, for the study time period, there were 907 deliveries in 2010, of which 102 (11.2%) patients were HIV positive and 4 (0.4%) had an unknown HIV status compared to 2011, with 865 deliveries of which 108(12.5%) patients were HIV positive and no patients had an unknown HIV status. Significantly more patients were diagnosed with HIV before they fell pregnant than during pregnancy in the 2011 group, when compared with the 2010 group. A CD4 count was done on 94% of patients who were newly diagnosed with HIV and those with an unknown CD4 count result in the 2010 group, compared to 92% in 2011. There was a significant improvement after the intervention in the time it took from when blood was drawn for a CD4 count until the result was followed up, the median time decreased from 34 to 8 days (p=0.000001). Significantly more patients qualified for highly active antiretroviral therapy (HAART) after the guidelines were changed and the CD4 cut off was increased to 350 cells/l (p=0.001). Prior the intervention 18 patients did not receive the correct management before delivery due to preventable reasons, compared to one at the MOU. After the intervention this decreased significantly to only one patient at Worcester Hospital and none at the MOU (p=0.000001). Before the intervention adherence to the PMTCT protocol at the MOU was significantly better than at the hospital (p=0.0005) and after the intervention there was no significant difference (p=1.0). CONCLUSION Although the audit and quality improvement cycle was performed at a single hospital, with specific changes geared towards their needs, the basic principles can be applied to any Unit in the country providing a PMTCT service. Educating staff, creating awareness and reminding staff of the basic principles of PMTCT, implementing small changes and streamlining processes and setting specific goals or timelines, can lead to significant improvements in care, which ultimately will lead to a decrease in PMTCT of HIV and HIV related maternal and infant morbidity and mortality.
AFRIKAANSE OPSOMMING: Die oorgrote meerderheid (>90%) van nuwe Menslike Immuniteitsgebreksvirus (MIV) infeksies in babas en jong kinders vind plaas deur middel van moeder-na-kind-oordrag, hetsy gedurende swangerskap, die kraamproses of borsvoeding. Sonder toegang tot perinatale voorkomingsprogramme (PMTCT) sal ongeveer 30% van alle babas jaarliks met MIV geïnfekteer word. DOELWITTE Die doel van die studie was om ‘n gehalteverbeteringsiklus by die Worcester Verloskunde Eenheid, wat bestaan uit Worcester Hospitaal, 'n streekshospitaal in die Wes-Kaapprovinsie en sy vlak een vroedvrou verlossingseenheid (VVE), te implementer en daarna te oudit, om sodoende die gehalte van die PMTCT-program te verbeter. Die intervensie het bestaan uit die implementering van eenvoudige veranderinge en prosesse in die voorgeboortekliniek, infeksiesiekte-kliniek en kraamsaal. METODES Die lêers en voorgeboorte rekords van alle MIV-positiewe pasiënte en pasiënte met 'n onbekende MIV-status, wat gedurende Januarie, Februarie en Maart van 2010 en 2011 verlos het by die Worcester Verloskunde Eenheid, is nagegaan. Alle MIV-negatiewe pasiënte en pasiënte met doodgebore babas en miskrame is uitgesluit. Die pre-intervensie bevindings van 2010 is vergelyk met die post-intervensie bevindings van 2011. RESULTATE By die Worcester Verloskunde Eenheid was daar 907 geboortes gedurende die studietydperk in 2010, waarvan 102 (11,2%) pasiënte MIV-positief was en 4 (0,4%) met ‘n onbekende MIV-status. In 2011 was daar 865 geboortes waarvan 108 (12,5%) pasiënte MIV-positief was en geen met 'n onbekende MIV-status. In die 2011-groep is beduidend meer pasiënte gediagnoseer met MIV voor as tydens swangerskap. In die 2010-groep is daar 'n CD4-telling gedoen vir 94% van nuut gediagnoseerde pasiënte en diegene met 'n onbekende CD4-telling, in vergelyking met 92% in 2011. Daar was 'n beduidende verbetering na die intervensie in die tyd wat dit geneem het vandat bloed getrek is vir 'n CD4-telling totdat die resultaat opgevolg is. Die mediane tyd het verminder vanaf 34 na 8 dae (p = 0.000001). Nadat die riglyne vir kwalifisering vir hoogs aktiewe antiretrovirale terapie (HAART) verander is na ‘n CD4 telling 350 selle/l het daar beduidend meer pasiënte gekwalifiseer vir HAART. By Worcester Hospitaal het 18 pasiënte voor die intervensie nie die korrekte behandeling intrapartum ontvang nie weens voorkombare redes, in vergelyking met slegs een pasiënt by die VVE. Na die intervensie was daar ‘n beduidende afname na slegs een pasiënt by Worcester Hospitaal en geen by die MOU (p = 0.000001). Voor die intervensie was die korrekte uitvoering van die PMTCT-protokol by die MOU beduidend beter as by die hospitaal (p = 0,0005) en na die intervensie was daar geen beduidende verskil (p = 1.0). GEVOLGTREKKING Alhoewel die oudit en gehalteverbeteringsiklus uitgevoer is by 'n enkele hospitaal, met spesifieke veranderinge gerig tot hul behoeftes, kan die basiese beginsels toegepas word in enige eenheid in die land wat ‘n PMTCT diens verskaf. Opvoeding van personeel en bewusmaking rakende die basiese beginsels van PMTCT, klein veranderinge en die vaartbelyning van prosesse by die voorgeboorte klinieke en die stel van spesifieke doelwitte of tydlyne, kan lei tot aansienlike verbeteringe in pasiënte sorg. Dit sal uiteindelik lei tot 'n afname in die MIV oordrag van moeder na kind, asook MIV-verwante morbiditeit en mortaliteit in moeders en kinders.
Varvel, Nicholas H. "THE ROLE OF BETA-AMYLOID AND INFLAMMATION IN NEURONAL CELL CYCLE EVENTS IN ALZHEIMER'S DISEASE MOUSE MODELS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1226609920.
Повний текст джерелаTeepe, Annette. "Relationship of Estrous Cycle to Herpes Simplex Virus Type 2 Susceptibility in Female Mice." Thesis, North Texas State University, 1987. https://digital.library.unt.edu/ark:/67531/metadc500408/.
Повний текст джерелаMilani-Nejad, Nima. "Regulation of Cardiac Contraction in Health and Disease: Studies from Animal Models to Humans." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397225239.
Повний текст джерелаSerquiña, Anna Kristina. "Studies on Cellular Host Factors Involved in the HIV-1 Life Cycle: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/646.
Повний текст джерелаColby-Milley, Jessica. "Characterization of the sleep-wake cycle in the TgCRND8 mouse model of Alzheimer's disease: from early to advanced pathological stages." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121302.
Повний текст джерелаLes individus atteints par la maladie d'Alzheimer (MA) démontrent une diminution des fonctions cognitives conduisant à une perte de la mémoire, le raisonnement, et la communication. Bien que la MA est associés à ses symptômes cognitifs, les patients peuvent aussi démontrer des symptômes non-cognitifs, tels que les troubles du sommeil. Les troubles du sommeil chez les patients atteintes de la MA incluent des éveils nocturne plus nombreux, et plus longues en duré que chez les sujets âgés sains, ainsi qu'une diminution du sommeil lent profonde, et dans les stades avancés, une diminution du sommeil paradoxal. Des changements dans la qualité du sommeil sont aussi présent, et peuvent être détecté par l'analyse des puissances spectrale des rythmes associés aux différents stades de sommeil. Pour déterminer si le modèle de la MA, la souris TgCRND8, reproduit les troubles de sommeil que l'on voit chez les patients, nous avons étudié la souris TgCRND8 a 3, 7 et 11 mois, des âges qui représentent des différentes stades pathologiques, définit par la quantité et la distribution de plaques amyloïdes ainsi que la pathologie neuritique, présent à partir de 5 mois. Durant la phase nocturne et la phase diurne, à tous les âges étudié, les souris TgCRND8 démontre une augmentation du temps passé éveillé et une diminution du sommeil lent en comparaison avec les souris non-transgénique (NTG). Une diminution du sommeil paradoxal a été observé à 3 et a 7 mois durant la phase nocturne, par contre, cet effet n'était pas présent durant la phase diurne à 3, 7 ou 11 mois. Après une dépravation total du sommeil, les souris TgCRND8 âges de 3 mois ont démontré une récupération homéostatique effective, suggèrent qu'une altération des mécanismes homéostatiques qui gèrent le sommeil ne contribue pas aux troubles de sommeil observé chez ses souris, à cette âge. L'analyse quantitative de l'électroencéphalogramme (EEG) a révèle une augmentation de la puissance spectrale dans la bande de fréquence gamma lent (20-50 Hz) durant l'éveil a 3, 7 et 11 mois et une diminution de la puissance spectrale des fréquences <1 Hz durant le sommeil lent a 3 et 11 mois. Durant le sommeil paradoxal, une diminution de la puissance spectrale dans la bande de fréquence alpha (9-14 Hz) a été observé à 7 et 11 mois et une augmentation dans la bande de fréquence gamma lent (20-50 Hz) à 7 mois. La tendance d'une augmentation de la puissance spectrale dans les bandes de fréquences rapide (gamma) est en accords avec l'augmentation prononcé du temps passe éveillé que l'on observe chez les TgCRND8 et pourraient être relié à des changements d'activité neuronale associé à l'accumulation de pathologie amyloïdes en absences de neurodégénérescence chez les souris TgCRND8. Étant donné le rôle de la transmission noradrénergiques dans la promotion de l'éveil, ainsi que les études démontrant la possibilités d'augmentation compensatoire d'activité noradrénergiques chez les patients atteints de la MA, les effets de prazosin, un antagonistes de récepteurs alpha-1-adrenergiques, ont été testé chez des souris NTG et TgCRND8 âges de 3.5 mois pour déterminé ci cela pourrait rétablir le sommeil lent chez les souris TgCRND8. A une dose de 2mg/kg, prazosin a augmenté la quantité total de sommeil lent chez les souris NTG mais pas les souris TgCRND8. A une dose plus élevé de 5 mg/kg, une augmentation de la quantité total du sommeil lent a été observé chez the souris NTG et aussi chez les souris TgCRND8. Etant donné que les souris TgCRND8 démontre une réaction différente à la dose faible de prazosin (2 mg/kg) en comparaison aux souris NTG, il est possible qu'il existe une altération dans le contrôle noradrénergique du sommeil chez les souris TgCRND8, est pourrait expliqué exigence d'une dose plus élevé (5 mg/kg) pour atteindre une augmentation du sommeil lent.
Maurissen, Thomas Luc. "Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation." Kyoto University, 2020. http://hdl.handle.net/2433/254520.
Повний текст джерелаMannan, Haider Rashid. "Development and use of a Monte Carlo-Markov cycle tree model for coronary heart disease incidence-mortality and health service usage with explicit recognition of coronary artery revascularization procedures (CARPs)." University of Western Australia. School of Population Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0101.
Повний текст джерелаKoh, Carline, and 許上冕. "Effects of right ventricular pacing and its interruption on left ventricular torsional mechanics and diastolic function in congenitalheart block." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45167199.
Повний текст джерелаBrandano, Laura A. "Investigation of the C-Terminal Helix of HIV-1 Matrix: A Region Essential for Multiple Functions in the Viral Life Cycle: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/552.
Повний текст джерелаAlvarez, Periel Elena. "Dual role of CDK5 on cognitive deficits and striatal vulnerability in Huntington’s disease." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663831.
Повний текст джерелаLa malaltia de Huntington (MH) és un desordre neurodegeneratiu causat per una mutació al gen que codifica per la proteïna Huntingtina (HTT), i que consisteix principalment en l’aparició de dèficits motors, associats a la degeneració selectiva de l’estriat; i en l’aparició de dèficits cognitius, associats a una alteració en la connectivitat corticoestriatal i a una disfunció hipocampal. En aquesta Tesi, hem analitzat la implicació de la cinasa Cdk5, per una banda, en l’aparició dels dèficits cognitius; i per l’altre banda, en la reentrada neuronal al cicle cel·lular com a un possible mecanisme de susceptibilitat a la vulnerabilitat estriatal en la MH. Els nostres resultats han mostrat que la reducció genètica de Cdk5 en un model murí de la MH (KI), prevé l’aparició dels dèficits cognitius corticoestriatal i hipocampals. Aquesta millora cognitiva està associada a la recuperació dels nivells de membrana de NR2B a nivell corticoestriatal, i a la restauració de la densitat d’espines dendrítiques a l’hipocamp i a l’escorça, indicant una implicació de Cdk5, complexa i específica de regió cerebral, en les alteracions sinàptiques i l’aparició dels dèficits cognitius en la MH. D’altre banda, hem observat que els nivells nuclears de Cdk5 estan disminuïts a l’estriat dels ratolins KI, cosa que podria alterar la seva funció com a inhibidor de la progressió del cicle cel·lular en neurones diferenciades. En concordança amb aquesta hipòtesi, diferents proteïnes del cicle cel·lular presenten una alteració en els seus nivells proteics, tant en ratolins KI, com en mostres de pacients humans. A més, l’activació dels receptors NMDA en neurones estriatals porta a una alteració de la distribució subcel·lular de les proteïnes del cicle cel·lular prèviament analitzades, un efecte que podria ser potenciat per la presència de la HTT mutada. En conclusió, els resultats d’aquesta Tesi, mostren la complexa implicació de Cdk5 en l’aparició dels dèficits cognitius en la MH, i suggereixen que l’alteració de la localització nuclear de Cdk5 podria portar a la desregulació de diferents proteïnes del cicle cel·lular, un mecanisme que es podria veure afavorit per alteracions en l’activació dels receptors NMDA, presents en la MH.
Seifert, Elena. "Metabolic Changes in Pulmonary Arterial Smooth Muscle Cells Exposed to Increased Mechanical Forces from an Ovine Model of Congenital Heart Disease with Increased Pulmonary Blood Flow." Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/cmc_theses/2094.
Повний текст джерелаEvans, Heather M. "IMMUNE EVASION BY DIVISION OF LABOR: THE TROPHIC LIFE CYCLE STAGE OF PNEUMOCYSTIS MURINA SUPPRESSES INNATE IMMUNITY TO THIS OPPORTUNISTIC, FUNGAL PATHOGEN." UKnowledge, 2017. http://uknowledge.uky.edu/microbio_etds/15.
Повний текст джерелаSantos, Marcus Vinicius Rezende dos. "O efeito do atraso em movimentos reversos do cotovelos : comparação entre sujeitos saudaveis e portadores da doença de Parkinson." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314247.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: Neste trabalho, foram investigados efeitos de condições especiais como o envelhecimento e a Doença de Parkinson no controle de movimentos reversos do cotovelo, realizados com um atraso variável entre a ida (Ml) e a volta (M2) do mesmo. Outro objetivo foi verificar se o ciclo de alongamento-encurtamento (CAE) age como potencializador da contração muscular nessa população. Foram recrutados 12 voluntários, sendo seis sujeitos saudáveis (três homens e três mulheres) com idades entre 51 e 71 anos (Média = 62.33 e DP = 8.95) e seis portadores da doença de Parkinson (três homens e três mulheres) com idades entre 59 e 77 anos (Média = 68.66 e DP = 7.47). Eles realizaram movimentos uni-articulares rápidos de reversão com o cotovelo, que se movia em direção à um alvo (Ml) e depois retomava à posição inicial (M2). Esses movimentos foram realizados em três diferentes distâncias (20°, 40° e 60°) e entre os dois componentes (Ml e M2) foi realizado um atraso variável (Os, 0.2s, 0.5s e ls). O deslocamento angular do cotovelo foi registrado por um sistema óptico de análise do movimento (OPTOTRAK@ 3020) e a atividade elétrica dos músculos braquiorradial (BRR) e cabeça lateral do tríceps braquial (TR) foi registrada através de um eletromiógrafo EMG DelSYS (modelo DE2.2L) com eletrodos de superficie. O envelhecimento saudável não influenciou os padrões EMG utilizados por esses indivíduos para ativar os músculos agonista e antagonista na realização de movimentos uni-articulares com reversão com diferentes atrasos. A velocidade dos movimentos executados por esses indivíduos foi mais baixa devido ao uso de um padrão semelhante aos sujeitos jovens, porém com uma menor quantidade de ativação. Os parkinsonianos moveram mais lentamente que os idosos saudáveis e indivíduos saudáveis devido a algumas alterações na modulação da atividade EMG. Apesar de apresentarem a manutenção do padrão trifásico, a atividade elétrica dos músculos ocorreu na forma de vários bursts altemantes durante toda a realização da tarefa, o que provocou uma redução na quantidade de ativida elétrica dos músculos. Os parkinsonianos não reduziram a magnitude do segundo burst agoninos movimentos sem atraso, o que trouxe uma dificuldade maior para reverter os moviment< Por fim, notou-se que os indivíduos portadores da doença de Parkinson relaxavam menos a SI musculatura e iniciavam o retomo à posição inicial necessitando de uma atividade maior do 1 para gerar uma velocidade igual à dos indivíduos saudáveis, o que não aconteceu. ( movimentos que reverteram sem atraso apresentaram um valor maior da velocidade movimento de retomo à posição inicial, mesmo nos portadores da doença de Parkinso confirmando a ação potencializadora do ciclo de alongamento-encurtamento (CAE) sobre músculo tríceps. Isso suporta a influência, tanto dos reflexos (gerados pelo estiramento muscula quanto da energia potencial armazenada pelo músculo e tendão, que têm suas origens na fa: excêntrica do CAE e são liberados no movimento de volta (fase concêntrica). Palavras-chave: Movimentos reversos, doença de Parkinson, ciclo de alongamento encurtamento, eletromiografia e cinemática
Abstract: Within this study were investigated the effects of special conditions like aging and the Parkinson's disease on the control ofreversal movements ofthe elbow joint performed with a variable delay between the two components (Ml and M2) ofreversal. Another aim was to verify if the stretch-shortening cycle exerts his potentiating effects on muscular contraction in this population. To perform these observations, 12 volunteers were recruited. Six of them (3 males and 3 females) were normal at their neurological assessment and were between 51 and 71 years of age (Mean = 62.33 e S.D.= 8.95), and the other six (3 males and 3 females) had been diagnosised with Parkinson disease and were between 59 and 77 years old (Mean = 68.66 e S.D. = 7.47). They executed fast single-joint movements with a reversal, moving towards a target (Ml) and getting back to the initial position (M2). These movements were accomplished in three different distances (20°, 40° and 60°) and between the two components ofreversal (Ml e M2) there were variable delays (Os, 0.2s, 0.5s eIs). The elbow angle was recorded using a optoelectric system of motion analysis (OPTOTRAK@ 3020) and the electrical activity of braquioradialis (BRR) and lateral head of triceps brachi (TR) muscles were recorded by a electromyograph EMG DelSYS (model DE2.2L) with surface electrodes placed over the muscles bellies. The aging did not affect the EMG patterns used by these persons in activating the agonist and antagonist muscles to accomplish single-joint movements with a delay between the movements toward the target and the return to the initial position. The velocity of movements executed by the elder1y volunteers was lower due to the fact that the same strategy applied to young hea1thy persons was used, however with less EMG activity. The volunteers with Parkinson's disease moved slower than the heaIthy elderly and young subjects due to aIterations in the modulation of EMG activity. Altough they kept the triphasic pattern, the EMG showed multiple bursts that aItemated during the task accomplishmen~ which decreased the amount of ellectricaI activity. Besides, they did not reduce the magnitude of second agonist burst in the reversaI movements without delay, what made the reversion harder. FinaIly, it was noticed that the parkinsonians showed less relaxation of his muscles during the intervaI between TI-T4, and started the return movement needing more TR activity to produce the same velocity, when compared to heaIthy persons, which was not the case. Those movements that reverted with no delay showed higher values concerning the second peak ofvelocity, even within the volunteers with Parkinson disease, sustaining the potentianting action of SSC over the triceps muscle. This effect comes from the influence of reflexes (generated by the muscle stretching), as well as the storage of elastic energy in the muscle and tendon in the eccentric phase of SSC, which are released at the movement of returning (concentric phase)
Mestrado
Fisiologia
Mestre em Biologia Funcional e Molecular
Vendrame, Édina. "Efeitos da posição social da infância e da vida adulta na perda dentária, nas doenças crônicas e na qualidade de vida relacionada a saúde bucal." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/151438.
Повний текст джерелаIntroduction: Since the socioeconomic trajectory can influence on individual health during the life course, we aimed to test a model of life course socioeconomic effects on tooth loss, chronic disease and Oral Health Related to Quality of Life. Method: This population-based study (n = 433) was held in Porto Alegre between 2010 and 2012 with the Public Health (PH) users aged 18 or over. The observable variables were: gender, age, smoking and number of teeth. Latent variables were Oral Health Impact Profile (OHIP), Socioeconomic Status in Childhood (SESC) Socioeconomic Status in Adulthood (SESA) and Chronic Disease (CD). Statistical analysis was performed using the Structural Equation Modeling (SEM) with Mplus software. For the final model only significant associations were kept (p<0.30). Results: The final model presented an adequate fit: RMSA 0.039, CFI 0.972, TLI 0.969 and WRMR 1.199. The effect of SESC on SESA was strong β = 0.59 (p<0.01). The direct effect of SESC on tooth loss was β = -0.08 (p = 0.19), and on chronic diseases was β = -0.14 (p = 0.10). The direct effect of SESA on tooth loss was β = -0.20 (p <0.01), and on OHIP was β = -0.14 (p = 0.05). The indirect effect of SESC on tooth loss was β = -0.12 (p = 0.02), and on OHIP was β = -0.14 (p = 0.01). The indirect effect of SESA on OHIP was β = -0.02 (p = 0.3). SESC has an indirect effect on OHIP and tooth loss via SESA, supporting the chain of effects theory. SESC and SESA have independent effects on tooth loss, supporting the accumulation theory. SESC has a direct effect on chronic diseases supporting the critical period theory. Conclusion: Investigations based on the life course approach relating to the oral health using SEM are necessary to understand the mechanisms and social determinants of health, causing inequalities.
Nassour, Ibrahim. "Depot et mobilisation des lipides corporels au cours du cycle sexuel chez la truite arc-en-ciel : effets d'une carence en acides gras essentiels sur la composition en acides gras des differents tissus." Paris 7, 1988. http://www.theses.fr/1988PA077128.
Повний текст джерелаMielke, Sarah Rebecca. "Environmental Persistence of Foot and Mouth Disease Virus and the Impact on Transmission Cycles in Endemic Regions." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1574079284530142.
Повний текст джерелаCabanas, Magali. "Modification des activités de réseaux in vivo chez un modèle murin de la maladie de Huntington." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0345/document.
Повний текст джерелаHuntington’s disease (HD) is an inherited pathology that causes selective degeneration ofindirect striatal pathway neurons of the basal ganglia. In addition to the classic motor,cognitive and psychiatric symptoms, patients and mouse models of HD develop sleepdisorders, which can appear at as early as pre-symptomatic stage. Furthermore, in vivoelectrophysiological study of R6/1 transgenic mice revealed a unique and pathological βrhythm that appear at early symptomatic stage and which is mainly observed during sleep.The aim of this thesis work was to examine the link between changes in cerebral networkactivities, sleep disturbances and β rhythm, and to determine the contribution of theseabnormalities to the behavioral disturbances observed in R6/1 mice. Our neuroimaging study of the marker of neuronal activity c-Fos showed a hyperactivation of frontostriatal pathway at pre-symptomatic stage without any activity changes of the vulnerable indirect pathway neurons. Our pharmacogenetic study demonstrated that changes of striatal projection neuronal activity can modify sleep/wake behaviors, without inducing the pathological β rhythm. Finally, our pharmacological study established a link between orexinergic system dysfunction and β rhythm emergence in R6/1 mice. Our data, therefore, described further the natures of altered neural circuit activity associated with different disease stages, in particular pre-motor symptomatic period, and the importance of these alterations for sleep disturbances as well as β rhythm appearance in transgenic HD mice
Dall\'Orto, Clarissa Campo. "Avaliação das interações das células endoteliais e das células musculares lisas arteriais com os inibidores do mammalian target of rapamycin (mTOR) na presença de soro rico em plaquetas." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5167/tde-05122018-115750/.
Повний текст джерелаINTRODUCTION: The long-term success of percutaneous coronary intervention, initially performed only with a balloon, was limited by the elastic recoil of the artery and by neointimal hyperplasia. There was improvement in this scenario with the advent of bare metal stents (BMS), because they decrease in restenosis, that resulting from a complex network of events initiated after the injury caused in the vascular wall by insufflation of balloons and apposition of the stent struts. Excessive proliferation of smooth muscle cells (VSMC) plays a key role in neointimal hyperplasia in the context of intrastent restenosis with consequent reduction of arterial lumen. With the advent of drug-eluting stents (DES) there was a significant decrease in neointimal hyperplasia and one of the drugs that proved effective in this role is sirolimus, which acts by binding to the binding protein 12 and the resulting heterodimer binds to mTOR preventing its activation and causing cell cycle arrest between G1 and S phases and thereby inhibiting the proliferation and migration of VSMC and also inhibiting endothelial cells (HUVEC). Therefore, coronary intervention interferes directly in the endothelium, interfering in the production of endothelial cells, not only in the quantitative aspect, but also in their function, and the functional quality of the endothelium is as fundamental as its presence. After the implantation of DES, especially those of the first generation, endothelial dysfunction occurs, whose main marker is the loss of the capacity of the vessel relaxation. There is also correlation between incomplete stem coverage and stent thrombosis. Consequently, it is possible to improve of the DES, so that they become devices with already achieved effectiveness in the prevention of restenosis but with a greater safety profile. The present study aims to evaluate the changes caused by DES in human HUVEC and VSMC in co-culture in the presence and absence of platelet-rich serum. MATERIALS AND METHODS: We used HUVEC and VSMC in monoculture and co-culture models in the presence and absence of platelet rich serum treated with BMS or DES. We performed the determination of IC50 for mTOR inhibitor, cytotoxicity evaluation by the colorimetric method of MTT, determination of lipid peroxide formation, cell cycle and expression of necrosis and inflammation markers. RESULTS: In the assessment of cytotoxicity by the MTT colorimetric method and determination of the IC50, VSMC were less sensitive to sirolimus than HUVEC (IC50 in 24/48 hours 14.85 uM/10.47uM and 9.48 uM/ 22.24 uM, respectively for HUVEC and VSMC). Platelets potentiate the oxidative stress generated by the presence of stents, possibly by increasing the inflammatory environment. Drug-eluting stents arrested VSMC and HUVEC in the G0/G1 phase of the cell cycle only with the addition of platelets to the culture medium. In cell culture models without platelets the cell cycle arrest was in G2/M. There was no increase of the cells in the fragmented DNA phase (sub-G0) evidencing that there was no induction of apoptosis. CONCLUSION: Human aorta smooth muscle cells of the were less sensitive to sirolimus than HUVEC. In coculture models with platelet addition, DES with sirolimus caused cell cycle arrest in the G0/G1 phase without induction of apoptosis, suggesting that sirolimus exerts its antiinflammatory effects in these cellular populations and consequently reduces neointimal hyperplasia via a cytostatic mechanism
Hannou, Sarah Anissa. "Rôle du régulateur du cycle cellulaire p16INK4a dans le développement du diabète de type 2 et dans les maladies métaboliques du foie gras ou NAFLD (Non-Alcoholic Fatty Liver Disease) : rôle de p16INK4a dans le contrôle de la néoglucogenèse hépatique et dans le développement de la stéatose hépatique non alcoolique." Thesis, Lille 2, 2014. http://www.theses.fr/2014LIL2S012/document.
Повний текст джерелаP16INK4a is a tumor suppressor protein well described as a cell cycle regulator. p16INK4a blocks cyclin D/ cyclin dependent kinase (CDK) 4 activity by binding to the catalytic subunit of CDK4, preventing retinoblastoma protein phosphorylation and subsequently the release of the E2F1 transcription factor. As a consequence; the transcription of genes required for progression to the S phase is restrained. Recently, genome-wide association studies (GWAS) associated the CDKN2A locus, encoding, amongst other genes, p16INK4A, with an increased risk of type 2 diabetes (T2D) development. However, the pathophysiological link between p16INK4a and hepatic glucose homeostasis remains unknown. In this context, we investigated the role of p16INK4a in hepatic glucose metabolism in vivo using p16+/+ and p16-/- mice and in vitro using primary hepatocytes and the AML12 hepatocyte cell line.p16-/- mice exhibited a higher response to fasting as shown by an increased hepatic gluconeogenic gene expression including phosphoenolpyruvate carboxykinase (PEPCK), fructose-1,6-biphosphatase (F1,6P) and glucose-6-phosphatase (G6Pase). p16-/- mice displayed an enhanced hepatic gluconeogenic activity in vivo upon administration of pyruvate, a gluconeogenic substrate. Consistent with this, in vitro data show that p16-/- primary hepatocytes display an enhanced gluconeogenic response to glucagon. In addition, knock down of p16INK4a by siRNA in AML12 cells increased gluconeogenic gene expression. These effects were associated with an increased activity of the PKA-CREB signaling pathway which leads to increased PPARg coactivator 1 (PGC1)α expression, a key transcriptional co-activator that regulates genes involved in energy metabolism. These findings describe a new function for p16INK4a as an actor in the hepatic adaptation to metabolic stress and suggest that p16INK4a could play a role during T2D development
Mongeon, Kevin. "The Study of Hereditary Spastic Paraplegia-Causing Gene DDHD2 Using Cell Models." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37474.
Повний текст джерелаLundberg, Martina Helena. "Role of cyclo-oxygenase and related pathways in vascular health and disease." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/14509.
Повний текст джерелаBishop-Bailey, David. "Induction of cyclo-oxygenase and nitric oxide synthase in vessels." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286016.
Повний текст джерелаCRUVINEL, Adriane Reis. "Epidemiologia da ferrugem asiática da soja em ambientes do Estado de Goiás: efeito de fungicida e época de semeadura." Universidade Federal de Goiás, 2005. http://repositorio.bc.ufg.br/tede/handle/tde/459.
Повний текст джерелаDuring the last crops, the soybean rust has been appeared as one of the most important problems in the national agriculture. The direct loses on the production and in the costs with fungicides have been increased the damages on this crop. Aiming to understand better the disease epidemiology, this work searched for answers by epidemic progress in two locations, the time of planting effect, the cycle of planting, the use of fungicide, and by different cultivars. The experiments were assembled in Experimental Stations from Agência Rural in Senador Canedo and in Anápolis. For each place were used three times of planting, six cultivars on the three crop cycles (Monsoy 6101 and BRSNina premature cycle; Emgopa 315 and BRSGO Santa Cruz middle cycle; Emgopa 313 and BRSGO Paraíso late cycle), with and without fungicide action, have been evaluated on the three parts of the plant (lower, middle and upper). Each time, to each one of the places, have been considered as an experiment with spli-split-plot. After the disease symptom observations, the split under chemical control were freaked each 21 days using pyraclostrobin+epoxiconazole on 66,5 g + 25 g a.i. ha-1. The evaluations, after the first symptom observation, have been done weekly up to the complete leaves took away. With the periodic severity data the Area Under Progress Disease Curve (AUPDC) and Relative Area Under Progress Disease Curve (RAUPDC), that is the area divided by the epidemic time duration, were calculated. The parameters were productivity, thousand-grains weight (TGW) and small grains percent (%SG). The delay on the start of the disease on Anápolis, comparing with Senador Canedo, increases the discussion on the results. The previous disease occurrence in Senador Canedo and the high level inoculate presented can be associated to the fact of experimental site in Senador Canedo has soybean cultivate all over the year. The delay on the start of the disease on Anápolis, compared to Senador Canedo has been resulted on productivity increase and fungicide effect decrease. Comparing the time of planting in both planting places, the second one presented the highest level of severity, but the highest level of productivity even. The use of fungicide decrease significantly the AUPDC, increase the productivity, the TGW and decrease the %SG. The premature cycle cultivars presented lowest disease severity. The cultivar Emgopa 315 although be a medium cycle presented results equals premature cycles cultivars. On each site the time of planting were differentiated. On high pressure inoculate condition the difference between evaluated factors was lower. On lower inoculate pressure the evaluated factors expressed better the changes. As conclusion we have: a) how early the disease appears higher is your effect on productivity; b) using premature cultivars the escape effect decrease the disease damages when compared to medium and late cycle; c) the disease decrease the soybean cycle by the defoliation; d) although all the cultivars presented susceptibility to rust, related to lower severity on partial resistance; e) the fungicide utilization pyraclostrobin+epoxiconazole on de 66,5 g + 25 g a.i. ha-1, used on first symptom and in 21 on 21 days decrease the disease progress and the effects on productivity; f) the disease progress decrease by fungicide utilization is better in late planting; g) under the fungicide effect pyraclostrobin+epoxiconazole with 66,5 g + 25 g a.i. ha-1 there s no variation time planting and site; h) under high inoculate pressure the variation between time planting on disease progress and productivity is lower; i) the time of planting must be considered but not lonely, always in association with others factors of fungus action; j) the use of RAUPDC is necessarily when there is variation the time of soybean cycle, affecting the rust epidemic duration; l) the highest disease level occurs on the part of the plant near the soil and the defoliation difficult the disease evaluation on this part of the plant; m) the most effective disease occurs on the highest parts of the plant.
Durante as últimas safras a ferrugem asiática da soja tem se apresentado como um dos maiores problemas na sojicultura nacional. Os prejuízos diretos pela queda da produção e os gastos com fungicidas têm acarretado prejuízos que vêm aumentando a cada safra. Objetivando compreender melhor a epidemiologia da doença, este estudo a buscou respostas para fatores como variação do progresso da epidemia em duas localidades, o efeito da época de semeadura, do ciclo da cultivar, do uso de fungicida e da resposta de diferentes cultivares. Os experimentos foram montados, nas Estações Experimentais da Agência Rural de Senador Canedo e de Anápolis. Para cada local foram utilizadas três épocas de semeadura, com seis cultivares nos três ciclos da cultura (Monsoy 6101 e BRSNina ciclo precoce; Emgopa 315 e BRSGO Santa Cruz ciclo médio; Emgopa 313 e BRSGO Paraíso ciclo tardio), com e sem a ação de fungicida, sendo avaliados os três terços da planta (inferior, médio e superior). Cada época, para cada um dos locais, foi considerada como um experimento com parcelas sub-sub-divididas. Após a observação dos sintomas da doença, as parcelas com controle químico foram pulverizadas a cada 21 dias com pyraclostrobin+epoxiconazole na dosagem 66,5 g + 25 g i.a. ha-1. As avaliações após o aparecimento da doença foram realizadas semanalmente até a queda completa das folhas. Com os dados de severidade periódicos calculou-se a Área Abaixo da Curva de Progresso da Doença (AACPD) e a Área Abaixo da Curva de Progresso da Doença Relativa (AACPDR), que consiste na divisão da área pelo período de duração da epidemia. As variáveis de rendimento obtidas foram: produtividade, massa de mil grãos (MMG) e porcentagem de grãos chumbinho (%CH). O atraso da entrada da doença em Anápolis, quando comparado a Senador Canedo, propiciou variações nos resultados que enriqueceram a discussão dos dados. A antecipação da ocorrência da doença em Senador Canedo e a alta pressão de inóculo apresentadas podem estar associadas ao fato da estação experimental em Senador Canedo possuir soja cultivada durante todo o ano. O atraso da entrada da doença em Anápolis, quando comparada a Senador Canedo, possibilitou um incremento na produtividade e menor efeito de fungicida. Entre as épocas avaliadas nos dois locais, a segunda apresentou os maiores índices de severidade, mas também os maiores índices de produtividade, fator relacionado às condições do ambiente. O efeito da utilização do fungicida diminuiu significativamente a AACPD, aumentou a produtividade, a MMG e diminuiu a %CH. Cultivares de ciclo precoce apresentaram menor severidade da doença, seguidos pelas cultivares de ciclo médio e tardio. A cultivar Emgopa 315 apesar de ser de ciclo médio apresentou resultados semelhantes às cultivares de ciclo precoce nas avaliações como um todo. Em cada local as épocas se comportaram de forma diferenciada. Em condições de alta pressão de inóculo a diferença entre os fatores estudados é menor. Para pressão de inóculo menor os fatores avaliados expressaram melhor suas variações. Como conclusões retiradas a partir dos resultados discutidos concluiu-se que: a) quanto mais cedo a ferrugem aparece durante o ciclo da cultura, maior é o seu efeito na produtividade da soja; b) a utilização de cultivares de soja de ciclo precoce propicia um efeito escape, que reduz os efeitos da ferrugem, quando comparado às cultivares de ciclo médio e tardio; c) a ocorrência da doença diminui o ciclo da cultura, antecipando seu término devido à desfolha prematura; d) apesar de todas as cultivares apresentarem suscetibilidade à ferrugem, algumas apresentam menor severidade relacionada a variações nos níveis de resistência parcial à doença; e) a utilização do fungicida pyraclostrobin+epoxiconazole na dosagem de 66,5 g + 25 g i.a. ha-1, aplicado a partir do aparecimento dos primeiros sintomas e posteriormente a intervalos de 21 dias diminuiu expressivamente o progresso da doença e seus efeitos nas variáveis de rendimento da soja; f) a redução do progresso da doença devido à aplicação do fungicida estudado é mais evidente com a semeadura tardia; g) sob o efeito da mistura pyraclostrobin+epoxiconazole na dosagem de 66,5 g + 25 g i.a. ha-1 não há variação entre época de semeadura e local; h) sob alta pressão de inóculo, as variações entre épocas de semeadura no progresso da ferrugem e no rendimento da cultura são menos explícitas; i) o fator época de semeadura não deve ser considerado isoladamente, mas sempre em associação a outros fatores que influenciam a ação do fungo como aplicação de fungicida, ciclo e resistência da cultivar; j) a utilização do parâmetro Área Abaixo da Curva de Progresso da Doença Relativa (AACPDR) é justificada para dados nos quais existe variação da duração do ciclo da soja, interferindo na duração da epidemia de ferrugem. Esta adequação se faz necessária para que os resultados de progresso da doença não sejam comprometidos; l) a parte da planta mais afetada pelos sintomas é o terço inferior e a desfolha dificulta a avaliação da doença nesta região; m) o controle mais efetivo da doença pelo fungicida ocorre nos terços superior e médio da planta
Hjort, Karin. "The cell cycle of the hyperthermophilic archaeal genus Sulfolobus." Doctoral thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3010.
Повний текст джерелаRilling, Klaus. "Beeinflussung der Apoptoserate und Zellzyklusprogression humaner T-Zellen durch den probiotischen E. coli Stamm Nissle 1917." Doctoral thesis, [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=978696336.
Повний текст джерелаQuinlan, Edward J. "Control of Bovine Papillomavirus E2 Function By Acetylation and the Novel E2 Interacting Protein RINT1: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/585.
Повний текст джерелаWang-Rosenke, Yingrui. "Nitric oxide-cGMP signal transduction in the injury, matrix expansion and progression of anti-thy1-induced renal disease of the rat." Saarbrücken VDM Verlag Dr. Müller, 2008. http://d-nb.info/991345665/04.
Повний текст джерелаDelmas, Véronique. "Structure et proprietes biologiques du papovavirus de hamster." Paris 6, 1986. http://www.theses.fr/1986PA066550.
Повний текст джерелаStemp, Melissa. "Biomarkers of disease : concentrations in the serum of women during natural and stimulated ovarian cycles and during early pregnancy." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2013. https://ro.ecu.edu.au/theses/865.
Повний текст джерелаMahmoud, Abady Maryam. "Modulation of growth factors and cell cycle regulatory molecules in experimental cardiomyopathy." Doctoral thesis, Universite Libre de Bruxelles, 2009. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210244.
Повний текст джерелаA number of growth factors are thought to play a role in pathologic cardiac remodeling.
Aims: We compared the modulation of the TGF-ƒÒ superfamily and IGF-1 signaling pathways and their target genes, the cell cycle regulatory proteins in tachycardia-induced dilated cardiomyopathy, a model with no detectable hypertrophy and in ischemic cardiomyopathy, a model with a marked hypertrophic reaction.
Methods: In the first study, endomyocardial biopsies were obtained weekly in 15 dogs, during the development of tachycardiomyopaty. Genes involved in the myostatin-TGF-ƒÒ-Activin-A/Smad signaling pathway, p21 and cyclin D were quantified and correlated to echocardiographic measures of hypertrophy. In the second study, myocardial tissue samples were obtained in 8 dogs with a healed myocardial infarction, in 8 dogs with heart failure induced by overpacing and in 7 healthy dogs. We measured gene expression of IGF-1, its receptor (IGF-1R) and cyclins A, B, D1, D2, D3 and E and correlated them to the level of hypertrophy.
Results: Tachycardiomyopathy was characterized by chambers dilation with no identifiable hypertrophy. Ischemic cardiomyopathy was characterized by eccentric hypertrophy. In tachycardiomyopathy, Activin-A mRNA was 4-fold higher than at baseline. Smad7 was overexpressed in severe heart failure; p21, a direct target gene of the Smad pathway was upregulated 8-fold and cyclin D1 was down-regulated. In that model, IGF-1 was overexpressed but neither IGF-1R nor any of the cyclins studied.
In ischemic cardiomyopathy, IGF-1, IGF-R, and cyclins B, D1, D3 and E gene expression were upregulated.
In tachycardiomyopathy, Activin-A and p21 were inversely correlated to the thickness of the interventricular septum. In normal dogs and in the both models of cardiomyopathy, IGF-1R was correlated to the thickness of the interventricular septum and to cyclins.
Conclusions: Taken together, these results agree with the notion that Activin-A, IGF and cyclins are involved in the modulation of hypertrophic response observed in cardiomyopathies.
Doctorat en Sciences médicales
info:eu-repo/semantics/nonPublished
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Повний текст джерелаMorel, Frédéric. "Etude experimentale du controle d'une famille de proteines de secretion d'un organe androgeno-dependant : l'epididyme de lezard." Clermont-Ferrand 2, 1987. http://www.theses.fr/1987CLF21074.
Повний текст джерелаStamateris, Rachel E. "CDK4 Rescues Diabetes in IRS2-Deficient Mice: Exploring Novel Roles of a Cell Cycle Regulator in Promoting Beta Cell Differentiation." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1138.
Повний текст джерелаSturm, Andreas. "Modulation intestinaler Wundheilungsvorgänge und Erhaltung der mukosalen Immunhomöostase." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/13916.
Повний текст джерелаThe intestinal mucosa protect the host from the potential harmful content of the intestinal lumen. To accomplish this difficult goal, the highly complex mucosa forms an anatomical as well as functional barrier to protect the organism.In this work, we aimed to characterize distinct aspect of the intestinal barrier, focussing on distinct regulation and repair mechanism of the intestinal mucosa. First, we demonstrate, that the phospholipid lysophosphatidic acid (LPA) stimulate the migration of intestinal epithelial cells, but, in contrast, inhibit their proliferation. This effect is mediated by G-protein receptors and is TGF-b-independent, as we could demonstrate in further experiments using bradykinine, phorbole ester, pertussis toxin and suramine to modulate distinct signalling pathways.We then demonstrated, using a well-established animal model of colitis, that LPA enhances intestinal wound healing in-vivo. In detail, the topical application of LPA in TNBS-treated rats reduced weight loss, ameliorate intestinal inflammation and prevented necrosis in the animals. This experiments demonstrate for the first time, that LPA modulates migration and proliferation of intestinal epithelial cells by distinct TGF-b independent pathways. Further experiments aimed to explore functional differences between peripheral blood (PBT) and mucosal T-cells (LPT). We demonstrated, that the cell cycle is distinctively regulated in PBT and LPT, identifying p53 as key regulator of LPT cell cycling. To avoid auto-immunity, the pool of effector T-cells must be depleted by apoptosis, once the antigen has been cleared. We demonstrate, that intrinsic pathway of apoptosis is activated during the antigen-induced cell death in LPT and that caspase-8 activity is required to execute LPT apoptosis. Cell cycle and apoptosis are ultimately linked. However, as we show in further experiments, this is not the case in LPT, underlining the distinct regulation of LPT cell cycle and apoptosis.In conclusion, using various distinct experimental tools, we demonstrate that the intestinal barrier itself and the modulation its function plays a fundamental role in the pathogenesis mucosal inflammation. The data presented in this work may therefore open new therapeutic options in the therapy of intestinal inflammatory disorders, such as inflammatory bowel diseases.