Дисертації з теми "Dienophiles"
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Siberdt, Fabian. "Action de dienophiles sur les 2-vinylindolizines." Doctoral thesis, Universite Libre de Bruxelles, 1995. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212576.
Повний текст джерелаLochrie, Ian Stewart Tolmie. "Investigation of diastereomeric induction in the Diels-Alder reactions of acylnitroso dienophiles." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320289.
Повний текст джерелаYoussofi, Abdullah. "Etude des dichloroboranes vinyliques en tant que dienophiles. Application a la synthese stereocontrolee d'heterocycles bicycliques azotes et oxygenes." Rennes 1, 1994. http://www.theses.fr/1994REN10186.
Повний текст джерелаLAMEIGNERE, ERIC. "Synthese de dienes et de dienophiles pyranosidiques en vue de leur utilisation dans la synthese de molecules naturelles polycycliques." Paris 11, 1990. http://www.theses.fr/1990PA112032.
Повний текст джерелаHaquin, Catherine. "Diaza-1,3 butadienes et isothiocyanates d'imidoyle : cycloaddition (1+4) avec les isonitriles et cycloaddition (2+4) avec quelques dienophiles electrophiles." Rennes 1, 1987. http://www.theses.fr/1987REN10036.
Повний текст джерелаYu, Jianguo. "Novel chiral phosphonium ionic liquids as solvents and catalysts for cycloadditions : investigation of the Diels-Alder reaction of a series of dienes and dienophiles in novel chiral phosphonium ionic liquids." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4307.
Повний текст джерелаNewbury, Daniel John. "Part A: Progress Towards the Total Synthesis of (±)-Communesin F; Part B: Aluminum as a Catalyst for the Diels-Alder Cycloaddition of Highly Hindered Dienophiles." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23943.
Повний текст джерелаCHAPTAL-GRADOZ, NATHALIE. "Regio et stereoselectivite de reactions de diels-alder entre des dienes portant un substituant allylique chiral en position deux et divers dienophiles. Applications." Paris 11, 1993. http://www.theses.fr/1993PA112310.
Повний текст джерелаByeon, Chang-Ho. "Part I. Reactions of alpha,beta-unsaturated thioesters and selenoesters with enamines :Part II. Alpha,beta-unsaturated thioesters and selenoesters as dienophiles :Synthesis of cyclohexene derivatives /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487856076418125.
Повний текст джерелаPerkins, Jonathan Clarence. "Synthesis of [2.2.2]-Diazabicyclic Alkaloids: I: Diels-Alder Reactions of a C2-Carboxy Pyrazinone & Ii: Intermolecular Diels-Alder Reaction of a Proline Derived Pyrazinone with Symmetric Dienophiles." W&M ScholarWorks, 2017. https://scholarworks.wm.edu/etd/1516639679.
Повний текст джерелаMcAllister, Graeme Douglas. "Development of an assay for a Diels-Alderase enzyme." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312729.
Повний текст джерелаClapham, Gary. "New Lewis acid promoted Diels-Alder reaction and transition catalysed hydrocarbons." Thesis, University of Exeter, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284618.
Повний текст джерелаAllen, Damian Arthur. "Facile synthesis of cis-2-alkyl-3-trialkylsilyloxycycloalkanones via the non-aldol aldol rearrangement of 2,3-epoxycycloalkanols ; and, Use of 4-cyanocoumarins as dienophiles in a facile synthesis of highly substituted dibenzopyranones ; and, Progress toward the total synthesis of N-methylwelwitindolinone C isothiocyanate." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1997737701&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Повний текст джерелаSmith, Sharon. "Studies of thioaldehydes and dienophilic dithioesters." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296966.
Повний текст джерелаDentel, Hélène. "Réactions asymétriques d'hétéro Diels-Alder impliquant un dienophile dithioester." Caen, 2011. http://www.theses.fr/2011CAEN2048.
Повний текст джерелаThe project was focused on the development of asymmetric hetero-Diels-Alder (HDA) reactions involving dithioester as dienophiles. The cycloadditions between dithioesters bearing an alcohol or an oxazolidinone as a chiral auxiliary and 2,3-dimethyl-1,3-butadiene led to diastereomeric excess up to 78%. In the enantioselective version, the best result (82% ee) was obtained with ethyl dithiooxalate and 2,3-dimethyl-1,3-butadiene in the presence of a chiral Cu(OTf)2/bis(oxazoline) complex. The enantioselectivity seems to be substrates/catalyst dependent yielding to difficult control. Even if this reaction is limited for synthetic applications, it represents the first example of a catalytic asymmetric HDA reaction with a chiral Lewis acid as activator of the thiocarbonyl partner. The absolute stereochemistry of each cycloadduct was assigned by structural correlation with a derivative analyzed by X-Ray. Double-stereodifferentiating experiments (chiral dithioester/chiral catalyst) have shown that the asymmetric induction is mainly controlled by the catalyst when dithiooxalate was involved. When an oxazolidinone dithioester was employed, the catalyst poorly influences the enantioselectivity, probably due to the different possible chelation modes between the dienophile and the Lewis acid (O,O vs S,O). To rationalize these results, we assume a tetrahedral geometry of the dithiooxalate/catalyst complex (S,O copper chelation) and a square-planar geometry with the oxazolidinone dithioester (O,O copper chelation). The theoretical study indicated that a chiral catalyst could accelerate the cycloaddition and induce asymmetry, with a bidentate chelation of the dithioesters to the metal
Schumann, Patrick Reiner. "Diastereomere Makrocyclen auf Basis von Bistriazol-Dienophilen und Sorbyl- und Sorboyl-Derivaten." Doctoral thesis, Universitätsbibliothek Chemnitz, 2008. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200800489.
Повний текст джерелаGuo, Zijian. "Developing unstrained alkenes and alkynes for bioorthogonal chemistry." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289423.
Повний текст джерелаEssers, Michael. "Diels-Alder-Reaktionen fluorierter Dienophile und Diene und ihr Einsatz in Synthesen fluorierter Steroidanaloga und Cantharidine." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=966627504.
Повний текст джерелаShah, Saral. "SOLUTION PROCESSIBLE AROMATIC POLYIMIDES VIA DIELS ALDER PRECURSOR." Master's thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3509.
Повний текст джерелаM.S.
Department of Chemistry
Sciences
Industrial Chemistry MS
Hickey, Eugene R. "Pi - facially nonequivalent cyclopentadienes : experimental and theoretical evaluation of the stereochemistry of dienophilic capture /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487848078448276.
Повний текст джерелаChopin, Nathalie. "Etude de la dienophilie des benzofurannes et indoles. Application à la synthèse d’analogues de la galanthamine." Rouen, 2008. http://www.theses.fr/2008ROUES017.
Повний текст джерелаThe Diels-Alder approach is a very convergent way of assembling heterocycles rapidly and stereoselectively. Because of their aromaticity, the electron-rich benzofurans and indoles have not been used very often as dienophiles in normal electron demand [4+2] cycloaddition. We have shown that, when properly substituted by electron withdrawing group in position 3, benzofurans can lead to desaromatised tricyclic cycloadducts featuring a quaternary carbon at ring junction and a cis stereochemistry. These oxygenated skeletons possess a framework common to Opium and Amaryllidaceae alkaloids, galanthamine, used in Alzheimer’s disease treatment, has been selected as a potential molecular target for the application of this approach. In order to develop this synthetic methodology, the influence of various substituents on the aromatic benzofuran ring was studied as well as the activation mode, thermal, hyperbaric and/or by Lewis acid. The cycloaddition reaction was optimized and the results gathered so far allow to envision total synthesis of galanthamine. The possibility of reaching the nitrogenated analogue azagalanthamine throught a similar approach using indoles was also considered. An intramolecular cycloaddition was envisaged and optimization of the synthesis of several substrates was carried out. The target tetracyclic adducts are similar to Büchi’s ketone, a key intermediate in the preparation Aspidosperma and Strychnos alkaloids
Steizer, Lindsay S. "Synthesis of polysubstituted pyridines : Diels-Alder addition of 1-AZA-1, 3-dienes with acetylenic and ethylenic dienophil." Virtual Press, 1986. http://liblink.bsu.edu/uhtbin/catkey/452401.
Повний текст джерелаDepartment of Chemistry
Goussé, Cécile. "Applications de la réaction de Diels-Alder aux polymères furaniques." Grenoble INPG, 1997. http://www.theses.fr/1997INPG0007.
Повний текст джерелаSancibrao, Pierre. "Cycloadditions de nitroso Diels-Alder asymétriques et régiosélectives : une nouvelle voie synthétique d'hétérospirocycles." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112417.
Повний текст джерелаDuring this research, we were interested in the synthesis of enantiopur heterospiranic bicycles. We therefore developed a new synthetic route towards the synthesis of molecules with different spirocyclic structures. This novel synthetic route features a nitroso Diels-Alder cycloaddition as key step. The total control of the stereoselectivity and the regioselectivity of the reaction, rarely described in the literature, have been specifically studied during this work. This study allows us to have a better understanding of this reaction. Two different approaches have been developed in this work. They both led to total control of the regioselectivity of this cycloaddition. Cycloadditions performed by reactions using a nitrosopyridine dienophile and catalyzed by a chiral source of copper allows the synthesis of cycloadducts precursor of azaspirocycles with a modest enantioselectivity. Cycloadditions using a chloronitroso chiral dienophile derived from xylose allowed the synthesis of oxaspiraniques precursors with enantioselective excess of at least 95%. The last approach was finally validated by the synthesis of various spiroethers and spirolactones through N-O bond cleavage an intramolecular cyclizations. Finally, the vinyl triflate function of the spirolactones and spiroethers was engaged in Suzuki couplings to introduce molecular diversity at a late stage allowing the synthesis of 9 different spiranic structures including 5 enantioenriched
Dorset, Rachel Ruth. "Cationic Diels-Alder dienophiles stablized by cobalt-complexed alkynes." 2010. http://hdl.handle.net/10090/15130.
Повний текст джерелаGuo, Peng. "New chiral dienophiles and their reactions with ortho-quinodimethanes." 1992. http://hdl.handle.net/1993/18027.
Повний текст джерела(14010168), Mirta Golic. "The preparation of dienes and dienophiles containing nucleic acid bases." Thesis, 1999. https://figshare.com/articles/thesis/The_preparation_of_dienes_and_dienophiles_containing_nucleic_acid_bases/21397758.
Повний текст джерелаThe work presented in this thesis deals initially with the synthesis of rigid polyalicyclic dienes and dienophiles with pyrimidine moieties inbuilt in a rigid fashion (building BLOCKS). This work has allowed the production of a new class of ribbon molecules with precisely defined size, shape and position of the pyrimidine ring. In the second stage of the project, an assessment of their ability to participate in cycloaddition reactions as pyrimidine building BLOCK* components was investigated.
2,4-Dimethoxy-1,3-diazaanthracene (I) has acted as the pyrimidine transfer reagent for preparing building BLOCKs. The Diels-Alder adducts IV and V (Scheme I), prepared by reaction of I with norbomadiene, are new pyrimidine dienophilic BLOCKs. Both I and 2,4-dichloro-1,3-diazaanthracene (II) were active in photochemical [4π+4π] cycloaddition reactions with cyclopentadiene to form a second class of building BLOCKs VII and VIII (Scheme I). In addition, the photodimerisation of I and II was studied and structures IX-XII assigned on the basis of spectral and X-ray method.
The 2,4-dichloro-photoadduct VIII is of particular importance for this work since it is easily hydrolysed (2M NaOH, 60 °C, overnight) to the corresponding uracil XIII In contrast, thermal adducts IV and V were very difficult to hydrolyse (NaOH fusion) to uracils XIV and XV (Figure I).
The availability of pyrimidine BLOCKs which contain a reactive π-bond, e.g. (IV, V, VII and VIII) has enabled us to employ 3,6-di(2'-pyridyl)-s-tetrazine (XVI) and ACE (Alkene plus Cyclobutene Epoxide) coupling methods to obtain precisely functionalised ribbon molecules in a direct, convergent synthetic strategy.
The synthesis of the bis-pyrimidines by coupling norbornene reagents using 3,6-di(2'-pyridyl)-s-tetrazine is illustrated in Scheme II. In the first step, s-tetrazine XVI was reacted with pyrimidine BLOCK V under basic conditions to generate the dihydropyridazine XVII. This diaza-1,3-diene was reacted with a further equivalent of V under high pressure conditions to yield the bis-pyrimidines XVIII and XIX, which were separated by radial chromatography. The same procedure was used to link pyrimiclines to other effectors by using alternative alkenes in the second step.
The ACE coupling protocol is illustrated by the reaction of alkene VIII with the dimethoxynaphthalene-containing epoxide XX (Scheme III). The reaction can be conducted under thermal or photochemical conditions and is considered to proceed via 1,3-dipolar intermediate formed by ring-opening of the epoxide C-C bond of XX (See Chapter 4).
Each class of coupled adduct could be hydrolysed to the corresponding uracil by using either acid (XXII) or base (XXIII) hydrolysis conditions, the choice depending on the structure of the molecule in question and its substituents.
The work presented in this thesis involves a deal of new work and has been instrumental in the development of the Lego®-based BLOCK assembly protocol for ribbon molecules construction.
Deng, Zong-Fan, and 鄧宗凡. "The study of chiral sulfinyl dienophiles in asymmetrical Diels-Alder reactions." Thesis, 1989. http://ndltd.ncl.edu.tw/handle/80821991665714901972.
Повний текст джерелаGao, Shih-Yu, and 高世育. "Highly regio- and stereocontrolled Diels-Alder reactions of masked o-benzoquinones with electron-rich dienophiles." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/91107565292952708613.
Повний текст джерела國立清華大學
化學系
88
The studies on the Diels-Alder reactions of masked o-benzoquinones (MOBs) 50 with electron-rich dienophiles and synthetic applications of Diels-Alder cycloadducts 56a-e are described. This thesis deals with the Diels-Alder reactions of MOBs with electron-rich dienophiles and the synthesis of bicyclo[2.2.2]octadienone derivatives. Diels-Alder reactions of MOBs 50 with four electron-rich dieno- philes namely, benzyl vinyl ether, 2,3-dihydrofuran, 3,4-dihydropyran and phenyl vinyl sulfide and a conjugated dienophile styrene afforded highly functionalized bicyclo[2.2.2]octenones 51a-g, 54a-g, 55a, 56a-g and 57a-h in high regio- and stereoselectivities. Based on RHF/3-21G* calculations, it is suggested that LUMO of MOBs and HOMO of benzyl vinyl ether, 2,3-dihydrofuran and styrene are involved in the inverse electron-demand Diels-Alder reactions. We have carried out the oxidation of Diels-Alder cycloadducts 56a-e derived from MOBs and phenyl vinyl sulfide with m-CPBA at -78 ℃ to produce the corresponding sulfoxides 63a-e in high yields. The sulfo- xides 63a-e at reflux temperature in mesitylene furnished bicyclo[2.2.2]- octa-2,5-dien-1-ones 64a-e in very good yields. The compounds 64a-e are immediate precursors for heteroaromatic-fused barrelenes, which are very useful starting materials for the photochemical rearrangements.
CHEN, QING-RONG, and 陳慶榮. "Applications of MerCO and its derivatives, (III) new chiral ��-sulfinyl dienophiles for asymmetric Dies-Alder reations." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/58203422026986292354.
Повний текст джерела山田, 浩貴, and Hiroki Yamada. "Enantioselective Diels–Alder Reaction Catalyzed by Chiral Ammonium Salts: The Synthetic Applications and the Design of New Dienophiles." Thesis, 2014. http://hdl.handle.net/2237/20271.
Повний текст джерелаAfarinkia, Kamyar, M. J. Bearpark, and A. Ndibwami. "A Computational and Experimental Investigation of the Diels-Alder Cycloadditions of Halogen Substituted 2(H)-pyran-2-one." 2003. http://hdl.handle.net/10454/2366.
Повний текст джерела4-Chloro-2(H)-pyran-2-one undergoes thermal Diels−Alder cycloaddition with electron-deficient dienophiles to afford, without any significant selectivity, 6-endo- and 5-endo-substituted bicyclic lactone cycloadducts. In contrast to 3- and 5-bromo-2(H)-pyran-2-one, 4-chloro-2(H)-pyran-2-one does not undergo thermal cycloadditions with electron-rich dienophiles. The regio- and stereochemical preferences of the cycloadditions of 4-chloro-2(H)-pyran-2-one and other related 2(H)-pyran-2-ones are investigated computationally. Calculations were carried out on the transition states leading to the four possible regio- and stereoisomeric cycloadducts using density functional theory (B3LYP/6-31G*). These studies allow prediction of the regio- and stereoselectivity in these reactions which are in line with experimental observations.
Pottie, Ian R. "Exploration of the inverse-electron-demand Diels-Alder (IEDDA) reaction. Rapid access to benzocoumarins via IEDDA-driven domino reactions of coumarin-fused electron-deficient dienes with electron-rich dienophiles /." 2002.
Знайти повний текст джерелаAldrin, Stephanie Vivian. "The Diels-Alder reaction synthesis of a cationic dienophile /." 2010. http://hdl.handle.net/10090/15119.
Повний текст джерелаRichter, Frank [Verfasser]. "Intramolekulare Diels-Alder-Reaktionen mit sauerstoffhaltigen cyclischen Dienophilen / vorgelegt von Frank Richter." 2002. http://d-nb.info/974165050/34.
Повний текст джерелаChang, Yan-Long, and 張言隆. "Effects of High Pressure on the Photosensitized Diels-Alder Reactions of Electron-rich Dienophile." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/03859899152176649430.
Повний текст джерелаLatta, Paul Richard. "Synthesis of diene and dienophile substrates for in-vitro selection of RNA-hetero-diels-alder catalysts." 2004. http://www.lib.ncsu.edu/theses/available/etd-04292005-132210/unrestricted/etd.pdf.
Повний текст джерелаSchumann, Patrick Reiner [Verfasser]. "Diastereomere Makrocyclen auf Basis von Bistriazol-Dienophilen und Sorbyl- und Sorboyl-Derivaten / vorgelegt von Patrick Reiner Schumann." 2008. http://d-nb.info/989724417/34.
Повний текст джерелаEssers, Michael [Verfasser]. "Diels-Alder-Reaktionen fluorierter Dienophile und Diene und ihr Einsatz in Synthesen fluorierter Steroidanaloga und Cantharidine / Michael Essers." 2001. http://d-nb.info/966627504/34.
Повний текст джерелаLording, William James. "A deeper understanding of the Diels–Alder reaction." Phd thesis, 2010. http://hdl.handle.net/1885/11776.
Повний текст джерела