Статті в журналах: "Diagnostic cumulatif"

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Bjustrom-Kraft, Jordan, Jane Christopher-Hennings, Russ Daly, Rodger Main, Jerry Torrison, Mary Thurn, and Jeffrey Zimmerman. "The use of oral fluid diagnostics in swine medicine." Journal of Swine Health and Production 26, no. 5 (September 1, 2018): 262–69. http://dx.doi.org/10.54846/jshap/1091.

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Swine veterinarians in North America have applied oral fluid-based testing methodologies for an increasing number of systemic, respiratory, and enteric disease diagnostic applications. Since the first report of oral fluid testing in 2008, nucleic acid and antibody assays have been described in the peer-reviewed literature for many pathogens affecting swine. As evidence of the US swine industry’s growing utility of oral fluids as a diagnostic tool, the cumulative number of swine oral fluid diagnostic tests conducted at three veterinary diagnostic laboratories in the upper Midwest (Iowa State University, South Dakota State University, and University of Minnesota) has increased from approximately 21,000 tests in 2010 to nearly 370,000 tests in 2016. The objective of this review is to describe the developments in oral fluid diagnostics that have led to its widespread use and to highlight areas of concern as this technology is increasingly implemented by producers and veterinarians.

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Fernández, Javier, and Fernando Vazquez. "The Importance of Cumulative Antibiograms in Diagnostic Stewardship." Clinical Infectious Diseases 69, no. 6 (January 30, 2019): 1086–87. http://dx.doi.org/10.1093/cid/ciz082.

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Asfora, Viviane K., Marcelo B. Freitas, Regina B. Medeiros, Hugo R. Schelin, Akemi Yagui, Marcus V. L. Oliveira, Luiz M. S. A. Leite, et al. "An Approach to Establishing Diagnostic Reference Levels in Interventional Pediatric Cardiology from Different Regions of Brazil." Children 11, no. 2 (February 5, 2024): 200. http://dx.doi.org/10.3390/children11020200.

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Diagnostic reference levels (DRLs) are a pivotal strategy to be implemented since pediatric interventional cardiology procedures are increasing. This work aimed to propose an initial set of Brazilian DRLs for pediatric interventional diagnostic and therapeutic (D&T) procedures. A retrospective study was carried out in four Brazilian states, distributed across the three regions of the country. Data were collected from pediatric patients undergoing cardiac interventional procedures (CIPs), including their age and anthropometric characteristics, and at least four parameters (number of images, exposure time, air kerma–area product—PKA, and cumulative air kerma). Data from 279 patients undergoing CIPs were gathered (147 diagnostic and 132 therapeutic procedures). There were no significant differences in exposure time and the number of images between the D&T procedures. A wide range of PKA was observed when the therapeutic procedures were compared to diagnostics for all age groups. There were significant differences between the D&T procedures, whether grouping data by patient weight or age. In terms of cumulative air kerma, it was noted that no value exceeded the level to trigger a monitoring process for patients. This study shows that it is possible to adopt them as the first proposal to establish national DRLs considering pediatric patient groups.

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Sommer, R., M. Augustin, and C. Blome. "Quality of life assessment and use of patient-reported outcomes in practice." Phlebologie 46, no. 06 (2017): 334–39. http://dx.doi.org/10.12687/phleb2382-6-2017.

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SummaryBackground: Patient-reported outcomes (PROs) are essential components of wound and vascular diagnostics and management. Aim: To provide an overview of PROs as diagnostic tools in the management of chronic wounds.Methods: Review of different concepts on inclusion of PROs in wound practice from literature.Results: PROs are indispensable sources of information for the understanding of the biopsycho- social context of wound diseases. Essential dimensions to be recorded are pain, health-related quality of life and patient benefit. Psychological parameters, adherence, treatment goals and treatment benefits are often needed. Further fields of interest include cumulative life course impairment, coping with disease, stigmatisation specifically applied according to clinical questions.Conclusion: Patient-reported outcomes are mandatory for the diagnostic work-up of chronic wounds. They also provide essential information in the course of a disease, can be diagnostic clues for non-adherence and treatment failures. Measurement of many PRO parameters in wound disease, such as health-related quality of life and pain, is facilitated by validated instruments, which are recommended for practice.

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Boop, Frederick A. "Cumulative diagnostic radiation exposure in children with ventriculoperitoneal shunts." Child's Nervous System 24, no. 4 (January 8, 2008): 499. http://dx.doi.org/10.1007/s00381-007-0561-9.

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Vinchon, Matthieu. "Cumulative diagnostic radiation exposure in children with ventriculoperitoneal shunts." Child's Nervous System 24, no. 4 (January 8, 2008): 501–3. http://dx.doi.org/10.1007/s00381-007-0562-8.

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Steinbok, Paul. "Cumulative diagnostic radiation exposure in children with ventriculoperitoneal shunts." Child's Nervous System 24, no. 4 (January 8, 2008): 505–6. http://dx.doi.org/10.1007/s00381-007-0563-7.

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D’Alessio, A., R. Matheoud, C. Siciliano, B. Cannillo, G. Margiotta Casaluci, G. Gaidano, and M. Brambilla. "CUMULATIVE RADIATION DOSES IN LYMPHOMA PATIENTS FROM DIAGNOSTIC PROCEDURES." Physica Medica 115 (November 2023): 102860. http://dx.doi.org/10.1016/j.ejmp.2023.102860.

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Matheoud, R., C. Siciliano, B. Cannillo, A. D’Alessio, G. Margiotta Casaluci, G. Gaidano, and M. Brambilla. "CUMULATIVE RADIATION DOSES IN LYMPHOMA PATIENTS FROM DIAGNOSTIC PROCEDURES." Physica Medica 115 (November 2023): 102861. http://dx.doi.org/10.1016/j.ejmp.2023.102861.

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Marchenkov, Artem, Dmitriy Chernov, Daria Zhgut, Anastasia Pankina, Ekaterina Rudenko, Anton Poroykov, Ekaterina Kulikova, and Tatiana Kovaleva. "Investigation of the Scale Factor Impact on the Results of Acoustic Emission Monitoring of the Steel Specimens Tension Process." Applied Sciences 12, no. 16 (August 19, 2022): 8280. http://dx.doi.org/10.3390/app12168280.

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The research is devoted to steel structure diagnostics by the acoustic emission (AE) method. The existing regulatory documents for AE diagnostics of metals and alloys do not take into account some critical factors, among which one is the scale factor should be highlighted. As a result, this can lead to an unreliable assessment of the danger degree of defects in structures when using standard AE diagnostic criteria. This paper presents a quantitative assessment of the scale factor impact on the AE data during the static tension test of steel specimens to failure. Experimental studies were carried out on flat specimens of various thicknesses with a side notch made of high-quality alloyed steel 30 KhGSA. It was established that AE data changed (rise in the AE signals amplitudes and AE activity) within the increase of specimen thickness. Growth in the recorded AE signals cumulative energy was registered with a greater specimen thickness. Partial correlation dependences of the mean count frequency and cumulative energy of AE signals on the specimen thickness were obtained. It was shown that such an effect occurred due to both a general increase in the deformed metal volume and greater strain intensity during the tension of thick specimens. The obtained dependences may contribute to the development of AE diagnostics of metallic materials which is invariant to the scale factor impact.

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Kochukhov, O. "Diagnostic of stellar magnetic fields with cumulative circular polarisation profiles." Astronomy & Astrophysics 580 (July 24, 2015): A39. http://dx.doi.org/10.1051/0004-6361/201526318.

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Schwartz, Robert G., and John Burress. "Diagnostic Musculoskeletal Ultrasonography and Cumulative Trauma Disorders of the Wrist." Journal of Orthopaedic Medicine 15, no. 1 (January 1993): 18–20. http://dx.doi.org/10.1080/1355297x.1993.11719711.

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Sahota, D. S., Y. Cheng, Y. Wah, and T. Leung. "P05.07: Cumulative risk adjusted assessment of diagnostic procedures loss rates." Ultrasound in Obstetrics & Gynecology 48, S1 (September 2016): 180. http://dx.doi.org/10.1002/uog.16535.

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Wang, Hai-Qiang. "Evaluating the Cumulative Impact of Ionizing Radiation Exposure With Diagnostic Genetics." Annals of Laboratory Medicine 39, no. 4 (July 1, 2019): 417–18. http://dx.doi.org/10.3343/alm.2019.39.4.417.

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Moloney, Fiachra, Daniel Fama, Maria Twomey, Ruth O’Leary, Conor Houlihane, Kevin P. Murphy, Siobhan B. O’Neill, Owen J. O’Connor, Dorothy Breen, and Michael M. Maher. "Cumulative radiation exposure from diagnostic imaging in intensive care unit patients." World Journal of Radiology 8, no. 4 (2016): 419. http://dx.doi.org/10.4329/wjr.v8.i4.419.

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Smyth, Matthew D., Prithvi Narayan, R. Shane Tubbs, Jeffrey R. Leonard, T. S. Park, Marios Loukas, and Paul A. Grabb. "Cumulative diagnostic radiation exposure in children with ventriculoperitoneal shunts: a review." Child's Nervous System 24, no. 4 (January 8, 2008): 493–97. http://dx.doi.org/10.1007/s00381-007-0560-x.

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Matheoud, Roberta, Ms Chiara Siciliano, Barbara Cannillo, Andrea D’Alessio, Gloria Casaluci Margiotta, Gianluca Gaidano, and Marco Brambilla. "CUMULATIVE RADIATION DOSES IN LYMPHOMA PATIENTS FROM DIAGNOSTIC PROCEDURES: PRELIMINARY RESULTS." Physica Medica 104 (December 2022): S151—S152. http://dx.doi.org/10.1016/s1120-1797(22)02480-2.

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De Vriendt, Patricia, Elise Cornelis, Wilfried Cools, and Ellen Gorus. "The Usefulness of Evaluating Performance of Activities in Daily Living in the Diagnosis of Mild Cognitive Disorders." International Journal of Environmental Research and Public Health 18, no. 21 (November 5, 2021): 11623. http://dx.doi.org/10.3390/ijerph182111623.

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The Assessment of Activities of Daily Living (ADL) is paramount to ensure the accurate early diagnosis of neurocognitive disorders. Unfortunately, the most common ADL tools are limited in their use in a diagnostic process. Hence, we set out to validate a tool to evaluate basic (b-), instrumental (i-), and advanced (a-) ADL called the Brussels Integrated Activities of Daily Living Inventory (BIA). At the geriatric day hospital of the University Hospital Brussels (Belgium) older persons (65+) labelled as Cognitively Healthy Persons (CHP) (n = 47), having a Mild Cognitive Impairment (MCI) (n = 39), and having Alzheimer’s disease (AD) (n = 44) underwent a diagnostic procedure for neurocognitive disorders. Additionally, the BIA was carried out. An exploration using both (cumulative) logistic regressions and conditional inference trees aimed to select the most informative scales to discriminate between the HCP, persons with MCI and AD. The distinction between CHP and MCI and between MCI and AD was moderately successful with the i-ADLs, in addition to age. Therefore, it is advisable to conduct a multidomain assessment in which the i-ADL could serve as non-invasive and non-time-consuming screening, while the BIA might be useful for diagnostics and disease management.

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Chen, Jersey, Andrew J. Einstein, Reza Fazel, Harlan M. Krumholz, Yongfei Wang, Joseph S. Ross, Henry H. Ting, Nilay D. Shah, Khurram Nasir, and Brahmajee K. Nallamothu. "Cumulative Exposure to Ionizing Radiation From Diagnostic and Therapeutic Cardiac Imaging Procedures." Journal of the American College of Cardiology 56, no. 9 (August 2010): 702–11. http://dx.doi.org/10.1016/j.jacc.2010.05.014.

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Thomson, Jodi. "Cumulative Exposure to Ionizing Radiation from Diagnostic and Therapeutic Cardiac Imaging Procedures." Journal of Emergency Medicine 40, no. 2 (February 2011): 241. http://dx.doi.org/10.1016/j.jemermed.2010.11.006.

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Cronin, Monica, Taylor K. Fadgen, Lisa Ogden, Jeremy P. Green, Stephanie A. Thatcher, Rebecca C. Young, and Brandon Hoelcle. "640. Development of a Laboratory Verification Protocol for Concurrent Detection of Bacterial, Fungal, and Antimicrobial Resistance Genes in a Multiplex Syndromic Joint Infection Panel." Open Forum Infectious Diseases 8, Supplement_1 (November 1, 2021): S423. http://dx.doi.org/10.1093/ofid/ofab466.837.

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Abstract Background Verification is a critical component of implementing a diagnostic test in a clinical lab and can be time consuming and costly. A verification protocol and organism panel were developed in collaboration with ZeptoMetrix®, LLC to verify all analyte detections for the BioFire® Joint Infection (JI) Panel*. The BioFire JI Panel detects 31 pathogens and 8 antimicrobial resistance (AMR) genes associated with joint infections from synovial fluid specimens. Methods A protocol was developed using prototype NATtrol™ controls from ZeptoMetrix®, synovial fluid, and the BioFire® FilmArray® 2.0 and the BioFire® FilmArray® Torch Systems. Control materials were tested in the presence of synovial fluid from pooled human donors. The 32 targets required for all analyte detections were divided into 5 pools of 6-7 analytes and then tested over multiple days on several systems. Results Preliminary outcomes were good with a cumulative positive detection rate of 100% (310/310) and expected negative detections of 99.3% (1182/1190) from 50 prototype BioFire JI Panel test runs. AMRs were correctly identified in 50/50 (100%) replicates when a correlated bacterium was present. Unexpected detections of Streptococcus spp. (7/50) and Staphylococcus lugdunensis (1/50) were likely due to contaminants in the synovial fluid; Streptococcus spp. was confirmed by testing the synovial fluid in isolation. Conclusion Efficient performance verification may be achieved by combining 32 organisms/8 AMR into 5 pools and can be completed with 20 test runs in 4 days. The pooling scheme provides multiple positive/negative detections per analyte and accurately detects AMR. The protocol and controls serve as a useful tool for providing reliable detections of targets over multiple days, operators and systems and offers a flexible solution for supporting verification needs. *The BioFire® Joint Infection Panel is currently pending US FDA De Novo review. This product has not been evaluated by other global regulatory agencies for in vitro diagnostic use. Not available for sale. Panel menu subject to change. Disclosures Monica Cronin, MS, BioFire Diagnostics, LLC (Employee) Taylor K. Fadgen, Bachelor of Science, BioFire Diagnostics, LLC (Employee) Lisa Ogden, BS, BioFire Diagnostics, LLC (Employee) Jeremy P. Green, BS, BioFire Diagnostics, LLC (Employee, Shareholder) Stephanie A. Thatcher, MS, BioFire Diagnostics (Employee) Rebecca C. Young, MS, BioFire Diagnostics, LLC (Employee) Brandon Hoelcle, BS, ZeptoMetrix, LLC (Employee)

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Dodd, Peter J., Jeff J. Pennington, Liza Bronner Murrison, and David W. Dowdy. "Simple Inclusion of Complex Diagnostic Algorithms in Infectious Disease Models for Economic Evaluation." Medical Decision Making 38, no. 8 (November 2018): 930–41. http://dx.doi.org/10.1177/0272989x18807438.

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Introduction. Cost-effectiveness models for infectious disease interventions often require transmission models that capture the indirect benefits from averted subsequent infections. Compartmental models based on ordinary differential equations are commonly used in this context. Decision trees are frequently used in cost-effectiveness modeling and are well suited to describing diagnostic algorithms. However, complex decision trees are laborious to specify as compartmental models and cumbersome to adapt, limiting the detail of algorithms typically included in transmission models. Methods. We consider an approximation replacing a decision tree with a single holding state for systems where the time scale of the diagnostic algorithm is shorter than time scales associated with disease progression or transmission. We describe recursive algorithms for calculating the outcomes and mean costs and delays associated with decision trees, as well as design strategies for computational implementation. We assess the performance of the approximation in a simple model of transmission/diagnosis and its role in simplifying a model of tuberculosis diagnostics. Results. When diagnostic delays were short relative to recovery rates, our approximation provided a good account of infection dynamics and the cumulative costs of diagnosis and treatment. Proportional errors were below 5% so long as the longest delay in our 2-step algorithm was under 20% of the recovery time scale. Specifying new diagnostic algorithms in our tuberculosis model was reduced from several tens to just a few lines of code. Discussion. For conditions characterized by a diagnostic process that is neither instantaneous nor protracted (relative to transmission dynamics), this novel approach retains the advantages of decision trees while embedding them in more complex models of disease transmission. Concise specification and code reuse increase transparency and reduce potential for error.

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Dannefer, Dale. "Racism and Cumulative Dis/Advantage in Healthcare Access: Implications for the Life Course." Innovation in Aging 4, Supplement_1 (December 1, 2020): 586. http://dx.doi.org/10.1093/geroni/igaa057.1958.

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Abstract Despite its origins in the study of race in America in Gunnar Myrdal’s American Dilemma, research on cumulative dis/advantage (CDA) and the life course has paid little attention to the significance of racism in the overall production and patterning of CDA. Building on recent work that has reviewed the life-course implications of the inscribing of racist interests in social policy, this paper explores the life-course implications of race bias in another domain, specifically the domain of medical diagnosis, where algorithm formulas have been shown to disadvantage black patients based on economic and other parameters. Even with training, experimental evidence comparing human and AI diagnostics have demonstrated that despite improvements, residual racism is evident in differential diagnoses. We consider the life-course implications of this and similar race-based differentials in organizational decision-making as a component in systems of cumulating dis/advantage.

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Vrzic-Petronijevic, S., I. Likic-Ladjevic, M. Petronijevic, R. Argirovic, and N. N. Ladjevic. "Diagnosis and surgical therapy of uterine sarkoma." Acta chirurgica Iugoslavica 53, no. 3 (2006): 67–72. http://dx.doi.org/10.2298/aci0603067v.

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Introduction: Uterine sarcomas are rare gynecological neoplasms and their classification is complicated. Uterine sarcoma is usually diagnosed in postmenopausal women and the diagnosis is often accidental and postoperative. Aim of this study was to present clinical and pathological characteristics of uterine sarcomas, diagnostic procedures, treatment and two-, three- and five-years cumulative survival rates. Materials and methods: The retrospective study of 61 cases of uterine sarcomas was conducted. Cases were distributed into groups based on definitive diagnosis of uterine sarcoma: group of leiomyosarcomas (LMS), carcinosarcoma (CS), endometrial stromal sarcomas (ESS), adenosarcomas (AS) and other rare uterine sarcomas. We investigated patients with clinical and pathological characteristics of uterine sarcomas, diagnostic procedures and treatment. Survival rate was calculated by Kaplan-Meier method. Results: From 61 patients 43 patients (70.49%) were postmenopausal. Mean period from menopause until appearance of symptoms was 14,63 years. One or more risk factors were present in 46 (75.4%) patients. Diagnosis of uterine sarcoma were established averagely 7.38 months after appearance of symptoms. 50 patients (82.0%) underwent one or more diagnostic procedures. Preoperative diagnosis of uterine sarcoma was established in 42.5% of patients. 53 (86.9%) of patients were treated operatively. The most used operative procedure (60,7%) was total hysterectomy with bilateral salpingooophorectomy. Postoperative pathohistologic analysis showed that low grade (LG) leiomyosarcoma were present in 19 (35.9%) cases, high grade (HG) leiomyosarcoma in 1 (1.9%) case, carcinosarcoma in 14 (26.4%) cases, low grade (LG) endometrial stromal sarcoma in 5 (9.4%) cases, high grade (HG) endometrial stromal sarcoma in 9 (17.0%) cases, adenosarcoma in 2 (3.8%) cases, and 2 cases of rare uterine sarcomas: 1 (1.9%) MALT HG lymphoma and 1(1.9%) malignant hemangiopericytoma. In one case of ESS (1.9%) only adenomyosis was found postoperatively suggesting that the whole tumour was removed during diagnostic procedure. Eight patients were not treated operatively. Two-years cumulative survival rate was 74.3%, three-years cumulative survival rate was 71.1%, and five years survival rate was 64.3%. Discussion: Average age, percent of postmenopausal patients and the mean age at the time of menopause in our studied correlate with current data. Clinical presentation of uterine sarcoma is associated with obesity and hypertension in more than 30% of cases, which is approved in our study. For early diagnostics it is important to notice that risk factors are similar to those connected with far more frequent endometrial carcinoma. Postmenopausal abnormal bleeding was the main reason for medical examination, explaining relatively short period for establishing the diagnosis in this group of patients. The variety of clinical findings in our studied group showed that the diagnosis must be based on preoperative pathohistology. Conclusion: Adequate diagnosis and treatment of uterine sarcoma is possible with regular yearly or more frequent follow-up, especially in postmenopausal women with known risk factors present. We need special attention for unclear symptoms and postmenopausal bleeding and we need to use all diagnostic procedures soon as possible including preoperative histology because early metastases are characteristic for uterine sarcomas. Factor of the most important predictive value is histologic grade. .

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Willems, J. L., P. Girard, D. Morlet, and P. Arnaud. "A New Method to Assess the Difficulty of a Medical Diagnosis: Application to Electrocardiographic Interpretation." Methods of Information in Medicine 32, no. 01 (1993): 59–65. http://dx.doi.org/10.1055/s-0038-1634889.

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Abstract:A new method to assess the relative difficulty of a medical diagnosis and the efficacy of a diagnostic procedure is described. The cases within a population are classified by N independent interpreters, i. e., medical experts or computer programs. The percentages of correctly diagnosed cases by N (unanimity), N-1, N-2, ..., zero interpreters, respectively, are calculated. These Nl + 1 percentages are presented in a histogram. A cumulative plot is derived from the “unanimity” value. The ratio “unanimity value”/“zero value” is proposed as an index of diagnostic performance. An application to the CSE database is presented which is composed of 1,220 electrocardiographic tracings interpreted by 13 cardiologists and 15 computer programs. The cumulative plots, the performance index and Log (index) values, established for eight different diagnostic statements, clearly show the relative degree of diagnostic difficulty for each of them and the particular efficacy of each approach, i. e., electrocardiography versus vectorcardiography, and computerized versus human interpretation.

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Rosenblum, Frida, Manuel Lora Gonzalez, Huma Fatima, Diana Lin, Xiao Huang, and Isam Eltoum. "Use of Cumulative Sum in the Assessment of Diagnostic Competency of Cytopathology Fellows." Journal of the American Society of Cytopathology 11, no. 6 (November 2022): S14. http://dx.doi.org/10.1016/j.jasc.2022.07.029.

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Angst, Jules, Alex Gamma, Martin Neuenschwander, Vladeta Ajdacic-Gross, Dominique Eich, Wulf Rössler, and Kathleen R. Merikangas. "Prevalence of mental disorders in the Zurich Cohort Study: a twenty year prospective study." Epidemiologia e Psichiatria Sociale 14, no. 2 (June 2005): 68–76. http://dx.doi.org/10.1017/s1121189x00006278.

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SUMMARYBackground — In order to minimise retrospective recall in developing estimates of the prevalence of mental dis-orders in the general population, we conducted a prospective study of a cohort of youth from Zurich, Switzerland. Method — A 20 year prospective study of a community-based cohort aged 19-20 from Zurich Switzerland. The sample was enriched by subjects scoring high on the Symptom Checklist 90 R (Derogatis, 1977). A semi-structured diagnostic interview was administered by clinically experienced psychologists and psychiatrists. The six interviews from 1979 to 1999 assessed diagnoses and sub-threshold manifestations of major diagnostic categories (with the exception of schizophrenia) for the past twelve months, depending on the current DSM versions (DSM-IH, DSM-HI R, DSM-IV). Additional information on symptoms and treatment were collected for the years between the interviews. The reported prevalence rates are weighted for stratified sampling and cumulate the one-year rates of the six interviews. Results — The cumulative weighted prevalence rates for any psychiatric disorder were 48.6% excluding, and 57.7% including tobacco dependence. In addition 29.2% and 21.8%, respectively manifested sub-diagnostic syndromes. Overall there were no significant gender differences. The corresponding treatment prevalence rates were 22.4% and 31.1%, respectively for the diagnostic subjects and 6.9% and 6.1 %, respectively for the sub-diagnostic groups. The total treatment prevalence rate was 37.2% of the population (males 30.0%, females 44.1%). Conclusions — Our findings reveal that psychiatric disorders are quite common in the general population. When the spectra of mental disorders are considered, nearly three quarters of the general population will have manifested at least one of the mental disorders across their lifetime. Limitations — The data are based on a relatively small sample; a single age cohort, and the study was conducted in Zurich, Switzerland. These study features may diminish the generalisability of the findings.Declaration of Interest: this work was supported by Grant 3200-050881.97/1 of the Swiss National Science Foundation, and Research Scientist Development Awards (MH 46376 and DA00293) from the US National Institutes of Health (Dr. Merikangas).

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Le Cosquer, Guillaume, Charlotte Maulat, Barbara Bournet, Pierre Cordelier, Etienne Buscail, and Louis Buscail. "Pancreatic Cancer in Chronic Pancreatitis: Pathogenesis and Diagnostic Approach." Cancers 15, no. 3 (January 26, 2023): 761. http://dx.doi.org/10.3390/cancers15030761.

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Chronic pancreatitis is one of the main risk factors for pancreatic cancer, but it is a rare event. Inflammation and oncogenes work hand in hand as key promoters of this disease. Tobacco is another co-factor. During alcoholic chronic pancreatitis, the cumulative risk of cancer is estimated at 4% after 15 to 20 years. This cumulative risk is higher in hereditary pancreatitis: 19 and 12% in the case of PRSS1 and SPINK1 mutations, respectively, at an age of 60 years. The diagnosis is difficult due to: (i) clinical symptoms of cancer shared with those of chronic pancreatitis; (ii) the parenchymal and ductal remodeling of chronic pancreatitis rendering imaging analysis difficult; and (iii) differential diagnoses, such as pseudo-tumorous chronic pancreatitis and paraduodenal pancreatitis. Nevertheless, the occurrence of cancer during chronic pancreatitis must be suspected in the case of back pain, weight loss, unbalanced diabetes, and jaundice, despite alcohol withdrawal. Imaging must be systematically reviewed. Endoscopic ultrasound-guided fine-needle biopsy can contribute by targeting suspicious tissue areas with the help of molecular biology (search for KRAS, TP53, CDKN2A, DPC4 mutations). Short-term follow-up of patients is necessary at the clinical and paraclinical levels to try to diagnose cancer at a surgically curable stage. Pancreatic surgery is sometimes necessary if there is any doubt.

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Зельчан, Р., R. Zel'chan, И. Синилкин, I. Sinilkin, А. Медведева, A. Medvedeva, О. Брагина, O. Bragina, В. Чернов, and V. Chernov. "Study of Pharmacokinetics of a New Radiopharmaceutical on the Basis of Technetium-99m Labeled Glucose." Medical Radiology and radiation safety 64, no. 5 (October 21, 2019): 35–41. http://dx.doi.org/10.12737/1024-6177-2019-64-5-35-41.

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Purpose: To study the features of the distribution and removal of a new radiopharmaceutical (RPH) on the basis of a labeled 99mTc glucose derivative for radionuclide diagnostics of oncological diseases in the body of experimental animals. Material and methods: The main stage of the study was performed on 65 mature conventional outbred white rats and 9 rabbits of the Soviet Chinchilla breed. To study the dynamics of changes in the concentration of the studied RPH in the blood plasma and its distribution in the main organs and tissues, as well as to study the metabolic features of the drug and its excretion, the RPH studied was administered intravenously, once in activity of 20 MBq. Multiple introduction of the RPH was performed in order to study the cumulative properties of the study drug, and to elucidate the possibilities of predicting the cumulation processes from the data obtained with a single administration of RPH. For this purpose, intravenous RPH was administered at the same time 1 time / day for 5 days, at a dose of 20 MBq. To confirm the theory of linearity of the pharmacokinetics of the RFP studied, three groups of laboratory animals received the drug in three activity levels – 10, 20 and 40 MBq were used. After euthanasia, the animals were autopsied and removed the necessary organs and tissues. The prepared and washed organs were placed in tubes for further radiometry in order to study the concentrations of the RPH in the bioassay. Results: It has been established that the RPH being studied practically does not accumulate in the main organs and tissues, accumulating mainly in the kidneys and bladder. The main organs of elimination of the test drug are the kidneys, and the main excreta are urine. The half-life of the drug from the blood was 10 minutes. Pharmacokinetics of the drug is linear and does not depend on the administered activity, and the drug itself does not possess cumulative properties. Conclusion: A study of the pharmacokinetics of the RPH 99mTc-1-Thio-D-glucose showed that the preparation possesses optimal properties for the diagnostic agent. The drug stably does not accumulate in the main organs and tissues, which allows it to be reused, for example at the stages of dynamic observation of cancer patients.

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Pace, Eric, Kelvin Cortis, Joseph Debono, Marvin Grech, and Carmel J. Caruana. "ESTABLISHING LOCAL AND NATIONAL DIAGNOSTIC AND INTERVENTIONAL CARDIOLOGY AND RADIOLOGY REFERENCE LEVELS IN A SMALL EUROPEAN STATE: THE CASE OF MALTA." Radiation Protection Dosimetry 191, no. 3 (September 2020): 261–71. http://dx.doi.org/10.1093/rpd/ncaa152.

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Abstract European Directive 2013/59/EURATOM requires the establishment and use of diagnostic reference levels (DRLs) for diagnostic and interventional procedures. The purpose of this study was to establish local DRLs for a major tertiary public hospital. As the hospital is the only such hospital in Malta, the same data collected for setting local DRLs can also be used for setting national DRLs, making local DRLs de facto national DRLs. A retrospective survey of cumulative kerma-area product (KAP) and fluoroscopy time data from the cardiac catheterisation laboratory and interventional radiology suites was carried out. The effect of system upgrades on cumulative KAP was also assessed. Local DRLs were set for common cardiology and interventional radiology procedures. All DRLs compare favourably with those in European literature. A Philips Allura Clarity upgrade to the cardiac catheterisation laboratories led to significant reductions in cumulative KAP (p ≪ 0.05) for most procedures.

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Reda, Islam, Ashraf Khalil, Mohammed Elmogy, Ahmed Abou El-Fetouh, Ahmed Shalaby, Mohamed Abou El-Ghar, Adel Elmaghraby, Mohammed Ghazal, and Ayman El-Baz. "Deep Learning Role in Early Diagnosis of Prostate Cancer." Technology in Cancer Research & Treatment 17 (January 1, 2018): 153303461877553. http://dx.doi.org/10.1177/1533034618775530.

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The objective of this work is to develop a computer-aided diagnostic system for early diagnosis of prostate cancer. The presented system integrates both clinical biomarkers (prostate-specific antigen) and extracted features from diffusion-weighted magnetic resonance imaging collected at multiple b values. The presented system performs 3 major processing steps. First, prostate delineation using a hybrid approach that combines a level-set model with nonnegative matrix factorization. Second, estimation and normalization of diffusion parameters, which are the apparent diffusion coefficients of the delineated prostate volumes at different b values followed by refinement of those apparent diffusion coefficients using a generalized Gaussian Markov random field model. Then, construction of the cumulative distribution functions of the processed apparent diffusion coefficients at multiple b values. In parallel, a K-nearest neighbor classifier is employed to transform the prostate-specific antigen results into diagnostic probabilities. Finally, those prostate-specific antigen–based probabilities are integrated with the initial diagnostic probabilities obtained using stacked nonnegativity constraint sparse autoencoders that employ apparent diffusion coefficient–cumulative distribution functions for better diagnostic accuracy. Experiments conducted on 18 diffusion-weighted magnetic resonance imaging data sets achieved 94.4% diagnosis accuracy (sensitivity = 88.9% and specificity = 100%), which indicate the promising results of the presented computer-aided diagnostic system.

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Jang, Mi-Ae, Eun-Ae Han, Hee Bong Shin, and You Kyoung Lee. "Correspondence: Response to “Evaluating the Cumulative Impact of Ionizing Radiation Exposure With Diagnostic Genetics”." Annals of Laboratory Medicine 39, no. 4 (July 1, 2019): 419–20. http://dx.doi.org/10.3343/alm.2019.39.4.419.

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Smookler, Gregory, and Alexis Deavenport-Saman. "Retrospective study of cumulative diagnostic radiation exposure during childhood in patients with spina bifida." Disability and Health Journal 8, no. 4 (October 2015): 642–45. http://dx.doi.org/10.1016/j.dhjo.2015.04.002.

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Cinner, Joshua E., M. Aaron MacNeil, Xavier Basurto, and Stefan Gelcich. "Looking beyond the fisheries crisis: Cumulative learning from small-scale fisheries through diagnostic approaches." Global Environmental Change 23, no. 6 (December 2013): 1359–65. http://dx.doi.org/10.1016/j.gloenvcha.2013.11.001.

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Martens, Patricia J., Randall Fransoo, Elaine Burland, Charles Burchill, Heather J. Prior, and Okechukwu Ekuma. "Prevalence of Mental Illness and its Impact on the Use of Home Care and Nursing Homes: A Population-Based Study of Older Adults in Manitoba." Canadian Journal of Psychiatry 52, no. 9 (September 2007): 581–90. http://dx.doi.org/10.1177/070674370705200906.

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Objectives: To determine the prevalence of mental illness in older adults and its effect on home care and personal care home (PCH) use. Methods: Using nonidentifying administrative records (fiscal years 1997–1998 to 2001–2002) from the Population Health Research Data Repository housed at the Manitoba Centre for Health Policy, we determined the 5-year period prevalence for individuals aged 55 years and over (119 539 men and 145 752 women) for 3 mental illness categories: cumulative mental disorders (those having a diagnosis of depression, anxiety disorder, personality disorder, schizophrenia, and [or] substance abuse), any mental illness, and dementia. We calculated age-specific and age-adjusted rates of home care and PCH use and the prevalence of mental illness in PCH residents. Results: From the group aged 55 to 59 years to the group aged 90 years or older, the prevalence of mental illness increased with the population's age. The prevalence of any mental illness rose from 32.4% to 45.0% in men and from 42.6% to 51.9% in women, and dementia prevalence rose from 2.0% to 33.6% in men and from 1.3% to 40.3% in women. The age-adjusted annual rates of open home care cases per 1000 population aged 55 and older varied by mental illness grouping (no mental disorder, 57 for men and 91 for women; cumulative mental disorders, 162 for men and 191 for women; dementia, 300 for men and 338 for women). The age-adjusted rates of PCH use per 1000 population aged 75 years and older also varied by mental illness grouping (no mental disorder, 53 for men and 78 for women; cumulative mental disorders, 305 for men and 373 for women; dementia, 542 for men and 669 for women). Among patients admitted to (or resident in) a PCH in 2002–2003, 74.6% (87.1%) had a mental illness, and 46.0% (69.0%) had dementia. Conclusions: Mental illness affects the use of home care and nursing homes profoundly. Individuals with dementia used home care at 3 times the rate of those having no mental illness diagnosis, and they used PCHs at 8 times the rate. Objectifs: Déterminer la prévalence de la maladie mentale chez les personnes âgées et son effet sur l'utilisation des soins à domicile et des foyers de soins personnels (FSP). Méthodes: À l'aide des dossiers administratifs anonymes (exercices financiers 1997–1998 à 2001–2002) du dépôt de données de recherche sur la santé de la population du centre de politiques en santé du Manitoba, nous avons déterminé la prévalence sur 5 ans, pour les personnes de 55 ans et plus (119 539 hommes, 145 752 femmes), de 3 catégories de maladie mentale: les troubles mentaux cumulatifs (ceux qui ont un diagnostic de dépression, de trouble anxieux, de trouble de la personnalité, de schizophrénie, et [ou] d'abus de substance), toute maladie mentale, et la démence. Nous avons calculé les taux par âge et les taux rectifiés selon l'âge d'utilisation des soins à domicile et des FSP ainsi que la prévalence de la maladie mentale chez les résidents des FSP. Résultats: La prévalence de la maladie mentale augmentait avec l'âge de la population, depuis le groupe des 55 à 59 ans jusqu'au groupe des 90 ans et plus. La prévalence de toute maladie mentale passait de 32,4 % à 45,0 % chez les hommes et de 42,6 % à 51,9 % chez les femmes, et la prévalence de la démence passait de 2,0 % à 33,6 % chez les hommes, et de 1,3 % à 40,3 % chez les femmes. Les taux annuels rectifiées selon l'âge des cas ouverts de soins à domicile par tranche de 1 000 de population de 55 ans et plus variaient selon le regroupement de maladies mentales (aucun trouble mental, 57 pour les hommes et 91 pour les femmes; troubles mentaux cumulatifs, 162 pour les hommes et 191 pour les femmes; démence, 300 pour les hommes et 338 pour les femmes). Les taux rectifiées selon l'âge d'utilisation des FSP par tranche de 1 000 de population de 75 ans et plus variaient aussi selon le regroupement de maladies mentales (aucun trouble mental, 53 pour les hommes et 78 pour les femmes; troubles mentaux cumulatifs, 305 pour les hommes et 373 pour les femmes; démence, 542 pour les hommes et 699 pour les femmes). Parmi les patients hospitalisés (ou résidents) des FSP en 2002–2003, 74,6 % (87,1 %) avaient une maladie mentale, et 46,0 % (69,0 %) souffraient de démence. Conclusions: La maladie mentale affecte profondément l'utilisation des soins à domicile et des établissements de soins prolongés. Les sujets souffrant de démence utilisaient les soins à domicile à 3 fois le taux de ceux qui n'avaient pas de diagnostic de maladie mentale, et les FPS, à 8 fois le taux des personnes sans diagnostic.

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Gil, Jong-Won, So Young Kim, Woo-Yoon Park, Won-Dong Kim, Young-Sung Lee, Gil-Won Kang, Dong-Wook Shin, Chan-Young Park, and Jong-Hyock Park. "ESTIMATION OF THE CUMULATIVE EXPOSURE FREQUENCY AND CUMULATIVE EFFECTIVE DOSE OF DIAGNOSTIC MEDICAL RADIATION IN THE KOREAN POPULATION FROM 2002 TO 2010." Radiation Protection Dosimetry 176, no. 3 (February 4, 2017): 203–10. http://dx.doi.org/10.1093/rpd/ncw382.

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Lippi, Giuseppe, Riccardo Nocini, and Henry Brandon. "Critical literature review and pooled analysis of diagnostic accuracy of Ortho VITROS SARS-CoV-2 antigen test for diagnosing acute SARS-CoV-2 infections." Journal of Medical Biochemistry 41, no. 4 (2022): 540–48. http://dx.doi.org/10.5937/jomb0-36107.

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Background: The present study is aimed at reviewing and meta-analyzing the currently published data on the diagnostic accuracy of Ortho VITROS SARS-CoV-2 antigen test for diagnosing acute SARS-CoV-2 infections. Methods: An electronic search was conducted in Scopus and Medline with the keywords "VITROS" AND "antigen" AND "COVID-19" OR "SARS-CoV-2" AND "immunoassay" within the search fields "TITLE" AND "ABSTRACT" AND "KEYWORDS", without no date (i.e., up to January 23, 2022) or language restrictions, aimed at detecting documents reporting the diagnostic accuracy of this SARSCoV-2 immunoassay compared with reference molecular diagnostic methods. Results: Overall, 5 studies (n=2734 samples) were finally included in our pooled analysis, four of which also provided diagnostic sensitivity in oro-and nasopharyngeal samples with high viral load. The pooled cumulative diagnostic sensitivity and specificity were 0.82 (95%CI, 0.78-0.86) and 1.00 (95%CI, 1.00-1.00), respectively, whilst the area under the curve was 0.995 (95%CI, 0.993-0.997), the cumulative agreement 97.2% (95%CI, 96.5-97.8%), with 0.89 (95%CI, 0.86-0.91) kappa statistics, thus reflecting an almost perfect concordance with reference molecular biology techniques. The pooled diagnostic sensitivity in samples with high viral load was as high as 0.98 (95%CI, 0.96-0.99). Conclusions: These results confirm that the automated and high-throughput Ortho VITROS SARS-CoV-2 antigen test may represent a valuable surrogate of molecular testing for diagnosing acute SARS-CoV-2 infections, especially in subjects with high viral load.

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Milani, Ana Luiza, Allan Felipe Fattori Alves, Matheus Alvarez, Samara Pavan Souza, Túlio Guilherme Soares Marques, Marcos Aureliano Araujo Silva, José Carlos Souza Trindade Filho, and Diana Rodrigues Pina. "Analysis of repeated computed tomography scans and cumulative effective dose of patients in a hospital." Brazilian Journal of Radiation Sciences 11, no. 2 (April 27, 2023): 01–14. http://dx.doi.org/10.15392/2319-0612.2023.2241.

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Computed tomography exams are considered diagnostic imaging exams that generate significant radiation dose to the patient. Justification, optimization, and dose limitation are radiological protection principles used to minimize patient and staff exposure, ensuring the quality of the service provided. The objective of this study was to analyze CT scan data, analyzing the number of exams, the patients' effective cumulated dose, and the repeatability of the exams. The study data covers the 2013 to 2022 period during which a progressive increase was observed in the number of exams performed over time, with exams doubling in this period. The most used Computed Tomography protocols were brain/skull (27.4%), pelvis (17.3%), and abdomen (13.7%) during the study period. Approximately 76.3% of patients have a cumulative dose of less than 25 mSv, while about 1% accumulated more than 100 mSv. The repeatability of CT scans for the same patient over a short period varies, reaching until 17 scans in 30 days for a single patient. The results indicated a necessity to develop strategies for individual dose management methods for the institution’s internal practices. An intervention could be implemented by creating periodically updated handouts and guidelines based on professionals' knowledge.

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Cilloni, Lucia, Emily Kendall, David Dowdy, and Nimalan Arinaminpathy. "Adaptive strategies for the deployment of rapid diagnostic tests for COVID-19: a modelling study." Gates Open Research 7 (January 27, 2023): 6. http://dx.doi.org/10.12688/gatesopenres.14202.1.

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Background: Lateral flow assays (LFAs) for the rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provide an affordable, rapid and decentralised means for diagnosing coronavirus disease 2019 (COVID-19). Concentrating on urban areas in low- and middle-income countries, we examined whether ‘dynamic’ screening algorithms, that adjust the use of confirmatory polymerase chain reaction (PCR) testing based on epidemiological conditions, could reduce cost without substantially reducing the impact of testing. Methods: Concentrating on a hypothetical ‘second wave’ of COVID-19 in India, we modelled the potential impact of testing 0.5% of the population per day at random with LFA, regardless of symptom status. We considered dynamic testing strategies where LFA positive cases are only confirmed with PCR when LFA positivity rates are below a given threshold (relative to the peak positive rate at the height of the epidemic wave), compared to confirming either all positive LFA results or confirming no results. Benefit was estimated based on cumulative incidence of infection, and resource requirements, based on the cumulative number of PCR tests used and the cumulative number of unnecessary isolations. Results: A dynamic strategy of discontinuing PCR confirmation when LFA positivity exceeded 50% of the peak positivity rate in an unmitigated epidemic would achieve comparable impact to one employing PCR confirmation throughout (9.2% of cumulative cases averted vs 9.8%), while requiring 35% as many PCR tests. However, the dynamic testing strategy would increase the number of false-positive test results substantially, from 0.07% of the population to 1.1%. Conclusions: Dynamic diagnostic strategies that adjust to epidemic conditions could help maximise the impact of testing at a given cost. Generally, dynamic strategies reduce the number of confirmatory PCR tests needed, but increase the number of unnecessary isolations. Optimal strategies will depend on whether greater priority is placed on limiting confirmatory testing or false-positive diagnoses.

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Armstrong, Elizabeth, and Virginia Weisz. "Diagnostic and Treatment Strategies for Vaginitis: A Literature Review." Journal of Doctoral Nursing Practice 9, no. 1 (2016): 139–44. http://dx.doi.org/10.1891/2380-9418.9.1.139.

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A literature review of vaginitis to identify relevance and gaps in diagnosis and treatment. Missed diagnosis in primary care and poor self-diagnosis leads to many women who are left untreated or treated inappropriately. The objective of this article is to review best diagnostic means of vaginitis and the current treatment recommendations for bacterial vaginosis, vulvovaginal candidiasis, and trichomoniasis. A search of literature using Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, and MEDLINE was limited to articles published between 1996 and 2014 and included original research, guidelines, and synthesis. Studies varied in quality and design, but several were randomized controlled trials.

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Acevedo-Mendez, Maria, Anil Rao, and Lewis L. Hsu. "Diagnostic Imaging Radiation in Severe Sickle Cell Disease: Cancer Risk Implications." Blood 138, Supplement 1 (November 5, 2021): 4944. http://dx.doi.org/10.1182/blood-2021-149911.

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Abstract Introduction: Patients with sickle cell disease (SCD) are repeatedly exposed to diagnostic radiation. Radiographs, computed tomography (CT) and nuclear medicine scans are often ordered for suspected complications caused by sickle cell disease that exposes patients with SCD to ionizing or another form of radiation. A few studies of low-dose cumulative radiation exposure (in people without SCD) suggest that 30 to 100 mSv over 30 decades is associated with higher excess risk of leukemia. New epidemiologic data of low quality suggests that individuals with sickle cell disease (SCD) accumulate "driver mutations" for acute myelogenous leukemia (AML) about 20-30 years earlier than the general population, and have higher risk of AML. In a gene therapy protocol with a few dozen patients, 2 cases of AML have occurred in sickle cell disease and none in thalassemia. It has been reported that children with SCD are frequently exposed to ionizing radiation in the form of plain radiographs, fluoroscopy, computed tomography (CT) scans, bone scans, and other tests. Exposure to ionizing radiation during childhood carries a risk of developing cancer that is directly related to the total radiation dose.Epidemiological data has demonstrated an increase both in diagnostic radiation and in actual or predicted resultant cancer diagnosis. Children are particularly vulnerable to radiation-induced cancer because they are still actively growing and thus are at greater risk of acquiring an oncogenic mutation in an actively dividing cell. Hypothesis: Frequent diagnostic imaging for children and adults with SCD can have significant cumulative radiation exposure that could add excess risk of AML. Methods: The study design was a retrospective chart review. The sample was selected to be enriched for the most severely-affected children and adults in the Sickle Cell Center at UI Health, which provides medical care for over 700 patients with SCD. The subgroup on chronic erythrocytapheresis blood transfusionswere selected as a sample of severe of SCD who are more likely to be exposed to repeated diagnostic radiation. Many have had stroke, which often leads to repeated head CT and cerebral angiograms. Others had pulmonary embolism or acute chest syndrome, which can lead to chest CT angiograms. Other SCD complications with high risk of morbidity or morbidity lead to similar likelihood that patients on chronic exchange transfusion therapy would have histories of multiple imaging studies. Medical records were reviewed for the type and number of all radiographic tests, especially CT scans, during the 10-year period 2011-2020. A second observer confirmed a subset of charts. Standard references were used to estimate radiation exposure in mSv for each type of test. The sum of mSv for each individual was a rough estimate of cumulative radiation in 10 years. The IRB approved the protocol. Results: Chart review on 39 patients (ages 16 - 60y) identified 1,030 radiographic tests with a mean of 26.4 tests/patient. Seven patients had > 50 tests, and one patient had > 100 tests over a 10-year period. Thirty-three patients had at least one CT scan. Eighteen patients had at least 3 CT scans. Twenty patients had cumulative radiation exposure > 30 mSv over a 10-year period, 4 patients had > 100 mSv, and one patient had > 200 mSv. Plain radiographs comprised 71% (736) of the studies and relatively low dose radiation exposure. Discussion: This retrospective study estimated that diagnostic radiography exposed 20 of 39 patients with severe SCD to the range of 30 to 200 mSv over 10 years, mostly from numerous CT scans. This range of cumulative radiation exposure has mixed evidence about possible heightened risk of AML and other cancers. The study is limited by the small sample at a single institution and a heavy bias toward patients with stroke and chest complications, but this severely-affected subgroup comprises many of those eligible for transplant and gene therapy in SCD. Cumulative exposure to diagnostic radiation might be one mechanism for the unexplained patterns of AML in SCD after gene therapy that led to a pause in SCD gene therapy studies for a few months in 2021. Further studies are needed. Disclosures Hsu: Global Blood Therapeutics: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Aruvant: Consultancy, Membership on an entity's Board of Directors or advisory committees; Hoffman LaRoche: Consultancy, Membership on an entity's Board of Directors or advisory committees; Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Forma Therapeutics: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Cyclerion: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Imara: Research Funding; Eli Lilly: Research Funding; Baxalta / Shire / Takeda: Research Funding.

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PERRY, MARCUS B., JOSEPH J. PIGNATIELLO, and JAMES R. SIMPSON. "A MAGNITUDE-ROBUST CONTROL CHART FOR MONITORING AND ESTIMATING STEP CHANGES IN A POISSON RATE PARAMETER." International Journal of Reliability, Quality and Safety Engineering 14, no. 01 (February 2007): 1–19. http://dx.doi.org/10.1142/s0218539307002477.

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Statistical process control charts are intended to assist operators in detecting process changes. If a process change does occur, the control chart should detect the change quickly. If the operator is provided with an estimate as to when the process changed, the search to find the special cause can be more easily facilitated. We investigate a process-monitoring tool for Poisson count data that quickly responds to process mean count rate changes regardless of the magnitude of the change, while supplying useful diagnostic information. A likelihood ratio approach was used to develop a control chart for a permanent step change in a Poisson process rate parameter. The average run length (ARL) performance of this chart is compared to that of several Poisson cumulative sum (CUSUM) control charts. Our performance results show that the proposed chart performs better than any one CUSUM chart over a wide range of potential shift magnitudes. The proposed chart also provides maximum likelihood estimates of the time and the magnitude of the process shift. These crucial change point diagnostics can greatly enhance the special cause investigation.

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Ivanov, I. A., K. V. Kostуukov, and G. E. Chernukha. "Echosonography’s accuracy of intrauterine pathology’s diagnostics in reproductive-age women." Meditsinskiy sovet = Medical Council, no. 5 (April 18, 2023): 22–28. http://dx.doi.org/10.21518/ms2023-107.

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Introduction. Accuracy of transvaginal sonography (TVS) is substantial as the first-line approach of intrauterine pathology diagnostics. However, TVS has some limitations and factors that reduce its accuracy have not been definitively determined.Aim. To evaluate the diagnostic accuracy of echography in intrauterine pathology and identify factors affecting it. Materials and methods. The study included 250 women who underwent hysteroscopy with endometrial biopsy: 128 with endometrial polyps (EP), 33 with endometrial hyperplasia (EH), 28 with chronic endometritis (CE) and 60 women without endometrial pathology.Results. The sensitivity and specificity of ultrasound in diagnosis of EP was 64.8% and 77.9%, respectively, EH – 64.7% and 89.8%, CE – 39.3% and 90.1%. Cumulative intrauterine pathology’s sensitivity reached 94.7%, and the specificity – 15.0%, which indicates a significant amount of false positive results. The lowest accuracy was in CE, EP less than 0.6 cm and in the absence of abnormal uterine bleeding.Conclusions. TVS has limitations in verifying a specific diagnosis and characterized by both hyper- and hypodiagnosis. The clinician should take into account the size of the EP and the presence of symptoms for choosing optimal management.

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Timoshenko, M. V., E. A. Perevedentsev, and S. P. Sherstyuk. "Non-Destructive Single-Revolution Electron Beam Profilometer based on a CCD Camera." SIBERIAN JOURNAL OF PHYSICS 18, no. 4 (April 12, 2024): 62–70. http://dx.doi.org/10.25205/2541-9447-2023-18-4-62-70.

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CCD cameras are easy to use and are quite widespread in the optical diagnostics of beams in particle accelerators. The exposure time of these cameras is milliseconds, so they are usually used in a cumulative mode to monitor the circulating beams. The images from the cameras contain information about the transverse distribution of particles in the beam and the position of the center of mass of the beam. In this paper, using the example of CCD cameras installed on the electron-positron collider VEPP-2000, the possibility of their use in the mode of a single beam flight through the observation site is investigated. The intensity of the luminous flux of the optical part of the synchrotron radiation spectrum of the beam was estimated and an image of the transverse distribution of particles in the beam in a single-span mode was experimentally obtained, which confirms the potential for expanding the scope of this diagnostic system. A trial signal processing was done as a demonstration of the determination of the beam parameters by the method under study.

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Soloperto, Rossana, Giovanna Guiotto, Giuseppe Tozzi, Maurizio Fumi, and Angelo Tozzi. "A Diagnostic Model to Predict SARS-CoV-2 Positivity in Emergency Department Using Routine Admission Hematological Parameters." Diagnostics 11, no. 9 (August 28, 2021): 1566. http://dx.doi.org/10.3390/diagnostics11091566.

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Early detection of SARS-CoV-2 in the emergency department (ED) is a crucial necessity, especially in settings of overcrowding: establishing a pre-diagnostic test probability of infection would help to triage patients and reduce diagnostic errors, and it could be useful in resource-limited countries. Here, we established and validated a clinical predictor of infection based on routine admission hematological parameters. The diagnostic model was developed by comparing 85 consecutive patients with symptomatic COVID-19 confirmed by RT-PCR with 85 symptomatic, SARS-CoV-2-negative controls. Abnormal hematological parameters significantly (p < 0.05) associated with SARS-CoV-2 infection were used to derive a “cumulative score” between 0 and 16. The model was validated in an independent cohort of 170 SARS-CoV-2-positive patients. Several routine hematology parameters were significantly (p < 0.05) associated with SARS-CoV-2 infection. A “cumulative score” score ≥7 discriminated COVID-19-postive patients from controls with a sensitivity of 94% and specificity of 100% (p < 0.001). The high sensitivity of the predictive model was confirmed in the prospective validation set, and the cumulative score (i) predicted SARS-CoV-2 positivity even when the first oro-nasopharyngeal swab RT-PCR result was reported as a false negative in both cohorts and (ii) resulted to be independent from disease severity. The cumulative score based on routine blood parameters can be used to predict an early and accurate diagnosis of SARS-CoV-2 infection in symptomatic patients, thereby facilitating triage and optimizing early management and isolation from the COVID-19 free population, particularly useful in overcrowding situations and in resource-poor settings.

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Stevenson, Carl W., and Meghan M. Leis. "The Cumulative Complexity Model and Repeat Falls." Professional Case Management 23, no. 4 (2018): 190–203. http://dx.doi.org/10.1097/ncm.0000000000000279.

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Atiyyah, Tarek Abd El-Rahman, Mohammed Sanad Naguib Nasr, Talaat Salahdin Ahmed, and Marwa Mohamed Sabri Abdelmonem Mostafa. "Cumulative Radiation Exposure from Diagnostic Imaging in Zagazig University Pediatric Intensive Care and Chest Units." Egyptian Journal of Hospital Medicine 81, no. 2 (October 1, 2020): 1520–24. http://dx.doi.org/10.21608/ejhm.2020.115566.

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Daly, Corinne, David Urbach, Therese A. Stukel, Wayne Deitel, Paul C. Nathan, Lawrence Frank Paszat, and Nancy N. Baxter. "Patterns of diagnostic imaging and cumulative radiation exposure among long-term young adult cancer survivors." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 6027. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.6027.

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6027 Background: Young adults surviving a diagnosis of malignancy have a considerable life expectancy, however, little is known about radiation exposure from diagnostic imaging in these patients. This study aims to describe patterns of imaging and radiation exposure in young adult cancer survivors (YAS) and cancer-free controls in Ontario, Canada. Methods: We conducted a population-based retrospective study. Young adults aged 20-44 diagnosed with an invasive malignancy between 1992 and 1999 who lived at least 5 years without recurrent disease were identified in the Ontario Cancer Registry. YAS were matched 1:5 to randomly selected cancer-free controls on calendar year of birth, sex, and geographic location. Radiological procedures were identified through Ontario Health Insurance Plan administrative data. The rate at which individuals underwent diagnostic procedures after surviving 5-years was compared between survivors and controls using Poisson regression. Cumulative radiation exposure due to computed tomography (CT) and standard x-ray were calculated. Results: 20,911 YAS and 104,524 controls had a median of 13.5 years observation time after cancer diagnosis/referent date. The rate of CT scanning after 5 year survival was higher in YAS (rate ratio= 3.59, 95% CI: 3.46 – 3.73) and varied according to malignancy type (Table). Over the course of diagnosis, treatment and surveillance to 10 years, the average YAS was exposed to 33.8 mSv of radiation, 4.4 times the radiation exposure an individual in the general population received. 47% of YAS cumulative dose was attributed to exposure 5 years or more after diagnosis. Conclusions: YAS undergo imaging and are exposed to diagnostic irradiation at a significantly higher rate than controls even after 5 years of recurrence free survival. Alternative imaging techniques not associated with exposure to radiation should be considered for these patients. [Table: see text]

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Iwanowski, J., H. Piwowarska-Bilska, P. Wawrykow, A. Walecka, J. Peregud-Pogorzelski, and B. Birkenfeld. "Exposure of children with neuroblastoma to ionizing radiation during computed tomography and nuclear medicine imaging – a single centre experience." Radioprotection 54, no. 3 (July 2019): 181–85. http://dx.doi.org/10.1051/radiopro/2019025.

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Purpose: To calculate cumulative doses of ionizing radiation absorbed by children with neuroblastoma during diagnostic CT and NM scans. Method: Retrospective analysis of 267 CT and NM scans performed in 21 children treated in 2009–2015. Results: The cumulative effective dose absorbed per child ranged from 58 to 536 mSv and was highest in infants under 3 years. Conclusion: Children with suspected neuroblastoma may be exposed to significant doses of radiation during the whole period of diagnosis and monitoring the progress of treatment.

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Cybulski, Robert, and Krzysztof Perlicki. "Design of WDM Transmission System for Medical Data Exchange." Journal of Telecommunications and Information Technology, no. 2 (June 30, 2014): 29–34. http://dx.doi.org/10.26636/jtit.2014.2.1019.

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This paper describes design of the Wavelength Division Multiplexing (WDM) transmission system using Alien Wavelength channels for medical data exchange. Main purpose of such system is to develop variety of services for medical cases diagnostics in order to comply with modern standards in telemedicine. Those standards refer to photo or video data transmission produced by diagnostic devices used in radiological centers together with text data concerning medical case analysis and patient data. These features are delivered by Picture Archiving and Communication System (PACS). PACS describes intra-hospital network organization, which applies to constructing system data from raw graphical data and text information according to Digital Imaging and Communications in Medicine (DICOM) version 3.0 standard. This standard is used by authors to evaluate necessary bit rate concerning all types of services delivered by PACS and cumulative throughput of link connections between hospitals and databases. Organization of this connections in metropolitan WDM system using advantages of Alien Wavelength technique is this article the main goal. Difference between configurable and non-configurable 10 Gigabit Small Form Factor Pluggable (XFP) end devices for Alien Wavelength channels are analyzed and compared with the standard approach using transponder cards.

Статті в журналах з теми "Diagnostic cumulatif"

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