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Статті в журналах з теми "Developmental biology/neurodevelopment"
Coutinho-Budd, Jaeda C., and Heather T. Broihier. "Pyroptosis Takes Aim at Neurodevelopment." Developmental Cell 53, no. 5 (June 2020): 498–99. http://dx.doi.org/10.1016/j.devcel.2020.05.013.
Повний текст джерелаArmstrong, F. Daniel, T. David Elkin, R. Clark Brown, Penny Glass, Renee C. Rees, Winfred C. Wang, and The Baby HUG Investigators. "Neurodevelopment in Infants with Sickle Cell Anemia: Baseline Data from the Baby HUG Trial." Blood 112, no. 11 (November 16, 2008): 713. http://dx.doi.org/10.1182/blood.v112.11.713.713.
Повний текст джерелаZapata-Muñoz, Juan, Beatriz Villarejo-Zori, Pablo Largo-Barrientos, and Patricia Boya. "Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health." Cell Stress 5, no. 7 (July 12, 2021): 99–118. http://dx.doi.org/10.15698/cst2021.07.253.
Повний текст джерелаNorkett, Rosalind, Wen Lu, and Vladimir I. Gelfand. "Repurposing Kinetochore Microtubule Attachment Machinery in Neurodevelopment." Developmental Cell 48, no. 6 (March 2019): 746–48. http://dx.doi.org/10.1016/j.devcel.2019.03.004.
Повний текст джерелаObst, Stefanie, Josephine Herz, Miguel A. Alejandre Alcazar, Stefanie Endesfelder, Marius A. Möbius, Mario Rüdiger, Ursula Felderhoff-Müser, and Ivo Bendix. "Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain Axis." Oxidative Medicine and Cellular Longevity 2022 (February 24, 2022): 1–17. http://dx.doi.org/10.1155/2022/5784146.
Повний текст джерелаGomes, Ana Rita, Nasim Bahram Sangani, Tiago G. Fernandes, M. Margarida Diogo, Leopold M. G. Curfs, and Chris P. Reutelingsperger. "Extracellular Vesicles in CNS Developmental Disorders." International Journal of Molecular Sciences 21, no. 24 (December 11, 2020): 9428. http://dx.doi.org/10.3390/ijms21249428.
Повний текст джерелаLauter, Gilbert, Iris Söll, and Giselbert Hauptmann. "13-P133 PACAP in zebrafish neurodevelopment." Mechanisms of Development 126 (August 2009): S235. http://dx.doi.org/10.1016/j.mod.2009.06.606.
Повний текст джерелаCarvill, Gemma L., and Heather C. Mefford. "Poison exons in neurodevelopment and disease." Current Opinion in Genetics & Development 65 (December 2020): 98–102. http://dx.doi.org/10.1016/j.gde.2020.05.030.
Повний текст джерелаChesnut, Megan, Thomas Hartung, Helena Hogberg, and David Pamies. "Human Oligodendrocytes and Myelin In Vitro to Evaluate Developmental Neurotoxicity." International Journal of Molecular Sciences 22, no. 15 (July 25, 2021): 7929. http://dx.doi.org/10.3390/ijms22157929.
Повний текст джерелаLu-Culligan, Alice, and Akiko Iwasaki. "The Role of Immune Factors in Shaping Fetal Neurodevelopment." Annual Review of Cell and Developmental Biology 36, no. 1 (October 6, 2020): 441–68. http://dx.doi.org/10.1146/annurev-cellbio-021120-033518.
Повний текст джерелаДисертації з теми "Developmental biology/neurodevelopment"
Czerminski, Jan T. "Modeling Down Syndrome Neurodevelopment with Dosage Compensation." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1037.
Повний текст джерелаDai, Lu. "EFFECTS OF CHROMIUM ON MOUSE SPLENIC T LYMPHOCYTES AND EFFECTS OF ETHANOL EXPOSURE DURING EARLY NEURODEVELOPMENT ON BEHAVIORS IN MICE." UKnowledge, 2017. https://uknowledge.uky.edu/toxicology_etds/18.
Повний текст джерелаSears, James Cooper. "FoxO Regulates Microtubule Dynamics and Polarity to Promote Dendrite Branching in Drosophila Sensory Neurons." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1476705366788041.
Повний текст джерелаSarn, Nicholas Brian. "MICROGLIA PATHOLOGY: AN INHERENT FEATURE OF CONSTITUTIONAL PTEN DYSFUNCTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1619526347351812.
Повний текст джерелаEmerson, Sarah Elizabeth. "Neurodevelopmental Roles of Semaphorin6A/PlexinA2 Signaling in Zebrafish." ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1058.
Повний текст джерелаKim, Seol-Hee. "Acetaminophen Associated Neurotoxicity and its Relevance to Neurodevelopmental Disorders." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6717.
Повний текст джерелаSchrötter, Sandra. "Specificity of developmental- and growth factor-dependent phosphorylation of Akt isoforms in neurons." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17593.
Повний текст джерелаA major pathway involved in neuronal development is the PI3K-PTEN-Akt pathway. Akt comprises three isoforms, which are activated by phosphorylation of the residues S473 and T308. KO animals for the isoforms have shown differential as well as redundant functions of the three isoforms. However, their individual role in neuronal signaling pathways has not yet been studied in great detail. The aim of this study was to obtain further insight into differential Akt isoform signaling in response to changes in the activity of PI3K and PTEN pathway. A new isoelectric focusing method was established, which allowed us to separate Akt proteins according to their charge, therefore, providing a refined read-out to study dynamics of Akt phosphorylation in a neuronal background. In the course of this project we were able to identify previously undescribed features of Akt phosphorylation and activation. First, we could provide evidence for an uncoupling of the two activating phosphorylation events at S473 and T308 in neuroblastoma cells and differential sensitivities of Akt1 forms towards PI3K inhibition. Secondly, we found a transient shift in Akt isoform activation and abundance during postnatal rat brain development. Thirdly, we were able to show that the activation of different Akt isoforms is dependent of the upstream signal as well as the age of the neuron. Immature neurons were found to be highly responsive to BDNF treatment, whereas mature neurons were most responsive to EGF stimulation leading exclusively to activation of Akt2 in an EGFR- and PI3K/p110α-dependent manner. Stimulation of Akt phosphorylation by the loss of PTEN led to an activation of mainly Akt1 forms, which suggests inherent differences in the Akt pools that are accessible to growth factors dependent PI3Ks as compared to the pools that are controlled by PTEN. In summary, this thesis demonstrates the presence of complex phosphorylation events of Akt in a developmental- and signal-dependent manner in neurons.
Moore, Daniel. "Novel Role of MeCP2 in Developing Oligodendrocytes and Myelination." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2516.
Повний текст джерелаDishaw, Laura Victoria. "Halogenated Organophosphate Flame Retardants: Developmental Toxicity and Endocrine Disruptive Effects." Diss., 2015. http://hdl.handle.net/10161/9838.
Повний текст джерелаFollowing the phase out of polybrominated diphenyl ethers (PBDEs), manufacturers turned to several alternative flame retardants (FRs) to meet flammability standards. Organophosphate FRs (OPFRs), and in particular tris (1,3-dichloropropyl) phosphate (TDCPP), have been increasingly detected in textiles and foam padding used in a variety of consumer products including camping equipment, upholstered furniture, and baby products. Like PBDEs, OPFRs are additive, meaning that they are not chemically bound to the treated material and can more readily leach out into the surrounding environment. Indeed, OPFRs have been detected in numerous environmental and biological matrices, often at concentrations similar to or exceeding that of PBDEs.
Although OPFRs have been in use for several decades, relatively little is known regarding their potential for adverse human and environmental health consequences. However, based on their structural similarity to OP pesticides, they may have analogous mechanisms of toxicity. OP pesticide toxicity is classically associated with cholinesterase inhibition, resulting in cholinergic intoxication syndrome. OPFRs have been shown to be ineffective cholinesterase inhibitors, however chlorpyrifos (CPF) and other OP pesticides have been shown to elicit adverse effects on developing organisms through other mechanisms.
The main objective of this research project was to evaluate the toxicity of four structurally similar OPFRs (TDCPP; tris (2,3-dibromopropyl) phosphate, (TDBPP); tris (1-chloropropyl) phosphate (TCPP) and tris (2-chloroethyl) phosphate (TCEP)) in comparison to chlorpyrifos (CPF), a well-studied OP pesticide. A combination of in vitro and in vivo models was used to elucidate potential mechanisms as well as functional consequences of exposure in developing organisms.
In the first research aim, a series of in vitro experiments with neurotypic PC12 cells was used to evaluate the effects of four structurally similar OPFRs (TDCPP, TDBPP, TCEP, or TCPP) and CPF on neurodevelopment. The effects of TDCPP were also compared to that of BDE-47, a major component of the commercial PentaBDE mixture. In general, TDCPP elicited similar or greater effects when compared to an equimolar concentration of CPF. All OPFRs tested produced similar decrements in cell number and altered phenotypic differentiation, while BDE-47 had no effect on cell number, cell growth, or neurite growth.
For the second research aim, zebrafish (Danio rerio) were used to evaluate the effects of the same suite of chemicals on early development. TDCPP, TDBPP, and CPF elicited overt toxicity (e.g., malformations or death) within the concentration range tested (0.033-100 µM). TDBPP was the most potent with 100% mortality by 6 days post fertilization (dpf) at ≥3.3 µM. CPF and TDCPP showed equivalent toxicity with malformations observed in at 10 µM and significant mortality (≥75%) at ≥33 µM. There was no overt toxicity among TCEP- and TCPP-exposed fish. All test chemicals affected larval swimming behavior on 6 dpf at concentrations below the overt toxicity threshold. Parent chemical was detected in all in embryonic (1 dpf) and larval (5 dpf) tissues. TDCPP and TDBPP showed rapid and extensive metabolism.
Finally, for the third aim, juvenile (45-55 dpf) zebrafish were exposed to CPF (1 µg/g food) or TDCPP (Low TDCPP = 1 µg/g food; High TDCPP = 40 µg/g food) via diet for 28 days followed by a 7 day depuration period where all treatments received clean food. A dietary exposure was chosen to more closely recapitulate exposure in humans. Samples were collected at seven time points throughout the experiment: days 0, 7, 14, 21, 28, 30, 35. Whole tissues were collected for tissue accumulation and histopathology endpoints. Viscera and brain were dissected and flash frozen separately for DNA damage analyses.
Tissue measurements of CPF, TDCPP, and the metabolite bis (1,3-dichloropropyl) phosphate (BDCPP) were often below the method detection limit, however when present there was a trend towards increased accumulation with treatment and time. On Day 7 Low TDCPP caused a dramatic but transient increase in DNA damage in both viscera and brain that returned to control levels by Day 14. Similar results have been seen previously with other genotoxicants and may be due to CPF and High TDCPP inducing an adaptive response prior to the 7 day sampling point. All treatments shifted the neurohypophysis to adenohypophysis ratio (NH/AH; Day 7 only) and significantly increased thyroid follicle activation (Day 14). Finally High TDCPP affected gonad maturation, causing a significant increase in ovary follicle development (Day 14) and a transient but marked decrease in testes maturity (Day 7). Taken together these data suggest that dietary exposure to TDCPP and CPF elicits DNA damage in brain and viscera and alters endocrine function in juvenile zebrafish. Importantly, analyses were restricted to the first three time points (Days 0, 7, and 14) due to the emergence a disease among the experimental colony. Although these samples were collected prior to the disease becoming apparent, it remains a potential confounder of the current results.
Dissertation
Choi, Yeyoon. "The role of AF1q in neural development." Thesis, 2019. https://hdl.handle.net/2144/36161.
Повний текст джерелаКниги з теми "Developmental biology/neurodevelopment"
Eyre, Janet. Neurodevelopmental disorders. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569381.003.0189.
Повний текст джерелаAlloway, Tracy Packiam, and Susan E. Gathercole. Working Memory and Neurodevelopmental Disorders. Taylor & Francis Group, 2015.
Знайти повний текст джерелаAlloway, Tracy Packiam, and Susan E. Gathercole. Working Memory and Neurodevelopmental Disorders. Taylor & Francis Group, 2012.
Знайти повний текст джерелаAlloway, Tracy Packiam, and Susan E. Gathercole. Working Memory and Neurodevelopmental Disorders. Taylor & Francis Group, 2012.
Знайти повний текст джерелаAlloway, Tracy Packiam, and Susan E. Gathercole. Working Memory and Neurodevelopmental Disorders. Taylor & Francis Group, 2012.
Знайти повний текст джерелаAlloway, Tracy Packiam, and Susan E. Gathercole. Working Memory and Neurodevelopmental Disorders. Taylor & Francis Group, 2012.
Знайти повний текст джерелаWorking Memory and Neurodevelopmental Disorders. Psychology Press, 2006.
Знайти повний текст джерела(Editor), Claudia Maria Vargas, and Patricia Ann Prelock (Editor), eds. Caring for Children With Neurodevelopmental Disabilities and Their Families: An Innovative Approach to Interdisciplinary Practice. Lawrence Erlbaum, 2004.
Знайти повний текст джерелаPrelock, Patricia Ann, and Claudia Maria Vargas. Caring for Children with Neurodevelopmental Disabilities and Their Families: An Innovative Approach to Interdisciplinary Practice. Taylor & Francis Group, 2004.
Знайти повний текст джерелаPrelock, Patricia Ann, and Claudia Maria Vargas. Caring for Children with Neurodevelopmental Disabilities and Their Families: An Innovative Approach to Interdisciplinary Practice. Taylor & Francis Group, 2004.
Знайти повний текст джерелаЧастини книг з теми "Developmental biology/neurodevelopment"
Crespi, Bernard, and Emma Leach. "The Evolutionary Biology of Human Neurodevelopment." In Developmental Approaches to Human Evolution, 205–30. Hoboken, NJ: John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118524756.ch9.
Повний текст джерелаNeuwirth, Lorenz S., Bright U. Emenike, Eddy D. Barrera, Nimra Hameed, Samantha Rubi, Teddy F. Dacius, Jourvonn C. Skeen, et al. "Assessing the Anxiolytic Properties of Taurine-Derived Compounds in Rats Following Developmental Lead Exposure: A Neurodevelopmental and Behavioral Pharmacological Pilot Study." In Advances in Experimental Medicine and Biology, 801–19. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-8023-5_69.
Повний текст джерелаPappas, Samuel S., Daniel K. Leventhal, Roger L. Albin, and William T. Dauer. "Mouse Models of Neurodevelopmental Disease of the Basal Ganglia and Associated Circuits." In Current Topics in Developmental Biology, 97–169. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-397920-9.00001-9.
Повний текст джерелаVohr, Betty R. "Prematurity: Impact on Neurodevelopmental and Behavioral Outcomes." In Cognitive and Behavioral Abnormalities of Pediatric Diseases. Oxford University Press, 2010. http://dx.doi.org/10.1093/oso/9780195342680.003.0050.
Повний текст джерелаТези доповідей конференцій з теми "Developmental biology/neurodevelopment"
Campolo, Domenico, Massimo Molteni, Eugenio Guglielmelli, Flavio Keller, Cecilia Laschi, and Paolo Dario. "Towards Development of Biomechatronic Tools for Early Diagnosis of Neurodevelopmental Disorders." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.260499.
Повний текст джерелаCampolo, Domenico, Massimo Molteni, Eugenio Guglielmelli, Flavio Keller, Cecilia Laschi, and Paolo Dario. "Towards Development of Biomechatronic Tools for Early Diagnosis of Neurodevelopmental Disorders." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.4398138.
Повний текст джерела