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Vives, Vilagut Roser. "Design of an exploratory development plan for the assessment of the activity of drugs for the treatment of chronic inflammatory dermatological diseases." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400199.
Повний текст джерелаBackground: The process of developing a drug from discovery to the market is a complex sequence of milestones that may take more than ten years. The duration, rate of failures and milestones vary greatly depending on the type of drug and the indication. Hypothesis: During the development of new molecular entities (NME) aimed for the topical treatment of inflammatory dermatological diseases (IDD), setting up an exploratory clinical development plan objective using efficient proof of concept (PoC) study designs, leads to obtaining robust and conclusive data in a short period of time, with minimal requirements of non-clinical and clinical data and minimizing the exposure of subjects participating in clinical trials to the investigational product, thus ensuring their safety. Objective: To identify the most efficient approach to explore the clinical activity of a NME for the topical treatment of IDD in terms of reliability of the results, non-clinical and clinical data requirements and in terms of exposed subjects, time to obtain activity data and investment required. Methods: A systematic review of regulatory guidelines issued by the ICH, EMA and FDA, as well as public assessment reports of topical dermatological products was done to identify the objectives of an exploratory development, and non-clinical and clinical studies required to initiate PoC studies. A systematic review of clinical trials of topical dermatological products in Aropic Eczema (AE) and Psoriasis published in the period January 2003-December 2013, to describe the type of designs used to obtain a PoC in terms of designs, number of patients, duration, type of variables and identify the most relevant clinical trial designs for PoC in AE and/or psoriasis was performed and for each type of design identified, a development plan with recommendations was proposed, estimating costs and duration and comparing the different approaches. Results: There is little information on how to plan the development of a NME for the treatment of AE or psoriasis by the topical route despite differences with respect to systemically administered products in terms of systemic exposure and safety issues may impact development plans. A total of 59 studies in AE and 40 in psoriasis were summarized and 3 main types of studies identified as relevant to assess the activity of a product applied topically on the skin: Randomized, parallel inter-subject study, Randomized, parallel, intra-subject comparison and Pharmacodynamic studies. For AE, two scenarios were proposed, where inter-subject and intra-subject studies were the PoC designs and for psoriasis a third scenario was proposed with a psoriasis plaque test as a PoC. After accounting for all previous data needed in each of the scenarios, and the particular features of development, an scenario implementing an intra-subject design for AE and with a psoriasis plaque test for psoriasis were proposed as the most efficient in terms of time and costs till a proof of clinical activity of a NME especially when it has a new mechanism of action. Conclusions: The design of the PoC study should be established early when planning the development as it will impact on the whole plan. Some approaches have been identified as more efficient although this may be influenced by different factors. A general regulatory guidance for early stage development requirements specific for topical dermatological products would be useful to adjust the amount of non-clinical testing to an extent that guaranties the safety of subjects exposed during clinical trials at the same time that avoids excessive use of resources, easing the development process and making it more efficient and predictable.
Badial, Peres Ramos [UNESP]. "Astenia dérmica regional hereditária equina: diagnóstico, ocorrência no Brasil e caracterização clinica." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/108390.
Повний текст джерелаEste estudo foi realizado para caracterizar os achados dermatológicos, oftalmológicos e morfológicos da pele de cavalos com Astenia Dérmica Regional Hereditária Equina (HERDA) e padronizar um ensaio de “High Resolution Melting” (HRM), para determinar a ocorrência de heterozigotos. As avaliações e a padronização do HRM foram realizadas em cinco cavalos afetados (GA) e cinco não afetados (GC). Adicionalmente, cinco animais heterozigotos (GH) foram utilizados para padronizar o HRM. A ocorrência de heterozigotos foi determinada em 690 animais. Diversas regiões da pele foram mensuradas com cutímetro no GA e GC. Biópsias de pele foram submetidas aos exames histopatológico e ultraestrutural. Avaliação histopatológica foi realizada por dois patologistas. O exame oftalmológico incluiu, além das avaliações rotineiras, aferição dos diâmetros da córnea, paquimetria e biometria. Foi extraído DNA do sangue colhido do GA, GC, GH e de 690 cavalos e o HRM foi validado. Observou-se menor espessura de pele no GA. A sensibilidade e especificidade do diagnóstico histopatológico da pele dependeram do avaliador e da região, respectivamente. Foram observados menor espessura e maior curvatura e diâmetros da córnea no GA. O HRM apresentou elevadas acurácia e precisão. A frequência de heterozigotos foi de 4,7%. Apesar do padrão regional dos sinais dermatológicos, a diminuição da espessura da pele não é regional. Para o diagnóstico histopatológico, recomenda-se realizar biópsia de pele no pescoço, garupa ou dorso. A relevância clínica dos achados oftalmológicos deve ser investigada. O ensaio de HRM padronizado será útil na seleção dos acasalamentos, visando minimizar a ocorrência da doença
The present study was conducted to characterize the dermatological, ophthalmological, and morphological findings from horses affected with Hereditary Equine Regional Dermal Asthenia (HERDA) and to standardize a High Resolution Melting (HRM) genotyping assay to determine the frequency of carriers. The evaluations and HRM standardization were performed in five affected (AG) and five non-affected (CG) horses. Additionally, five heterozygous (HG) horses were used to HRM standardization. The frequency of carriers was determined in 690 horses. Several skin regions of both groups were measured with a cutimeter Skin biopsies were submitted to histopathological and ultrastructural evaluations. Histopathological evaluation was performed by two pathologists. Ophthalmology included, besides the routine evaluations, corneal diameters measurement, pachymetry, and biometry. HRM was validated using purified DNA from blood samples of the AG, CG, HG and 690 horses. Skin thickness decrease was observed in the AG. Histopathological sensitivity and specificity to diagnose HERDA was dependent on the evaluator and region, respectively. HERDA horses exhibited decreased corneal thickness and increased corneal curvature and corneal diameters. The HRM assay resulted in high accuracy and precision. The estimated carrier frequency was 4.7%. Despite of the regional pattern of the dermatological signs, the decrease of skin thickness from HERDA horses is not regional. Skin samples of the neck, croup or back are recommended to diagnose HERDA. The relevance of the ocular findings should be further investigated. The standardized HRM assay will be useful in the management of breeding programs to minimize the occurrence of this disease
Badial, Peres Ramos. "Astenia dérmica regional hereditária equina : diagnóstico, ocorrência no Brasil e caracterização clinica /." Botucatu, 2013. http://hdl.handle.net/11449/108390.
Повний текст джерелаBanca: Carlos Alberto Hussni
Banca: João Pessoa Araújo Junior
Banca: Luiz Claudio Nogueira Mendes
Banca: Paulo Henrique Jorge da Cunha
Resumo: Este estudo foi realizado para caracterizar os achados dermatológicos, oftalmológicos e morfológicos da pele de cavalos com Astenia Dérmica Regional Hereditária Equina (HERDA) e padronizar um ensaio de "High Resolution Melting" (HRM), para determinar a ocorrência de heterozigotos. As avaliações e a padronização do HRM foram realizadas em cinco cavalos afetados (GA) e cinco não afetados (GC). Adicionalmente, cinco animais heterozigotos (GH) foram utilizados para padronizar o HRM. A ocorrência de heterozigotos foi determinada em 690 animais. Diversas regiões da pele foram mensuradas com cutímetro no GA e GC. Biópsias de pele foram submetidas aos exames histopatológico e ultraestrutural. Avaliação histopatológica foi realizada por dois patologistas. O exame oftalmológico incluiu, além das avaliações rotineiras, aferição dos diâmetros da córnea, paquimetria e biometria. Foi extraído DNA do sangue colhido do GA, GC, GH e de 690 cavalos e o HRM foi validado. Observou-se menor espessura de pele no GA. A sensibilidade e especificidade do diagnóstico histopatológico da pele dependeram do avaliador e da região, respectivamente. Foram observados menor espessura e maior curvatura e diâmetros da córnea no GA. O HRM apresentou elevadas acurácia e precisão. A frequência de heterozigotos foi de 4,7%. Apesar do padrão regional dos sinais dermatológicos, a diminuição da espessura da pele não é regional. Para o diagnóstico histopatológico, recomenda-se realizar biópsia de pele no pescoço, garupa ou dorso. A relevância clínica dos achados oftalmológicos deve ser investigada. O ensaio de HRM padronizado será útil na seleção dos acasalamentos, visando minimizar a ocorrência da doença
Abstract: The present study was conducted to characterize the dermatological, ophthalmological, and morphological findings from horses affected with Hereditary Equine Regional Dermal Asthenia (HERDA) and to standardize a High Resolution Melting (HRM) genotyping assay to determine the frequency of carriers. The evaluations and HRM standardization were performed in five affected (AG) and five non-affected (CG) horses. Additionally, five heterozygous (HG) horses were used to HRM standardization. The frequency of carriers was determined in 690 horses. Several skin regions of both groups were measured with a cutimeter Skin biopsies were submitted to histopathological and ultrastructural evaluations. Histopathological evaluation was performed by two pathologists. Ophthalmology included, besides the routine evaluations, corneal diameters measurement, pachymetry, and biometry. HRM was validated using purified DNA from blood samples of the AG, CG, HG and 690 horses. Skin thickness decrease was observed in the AG. Histopathological sensitivity and specificity to diagnose HERDA was dependent on the evaluator and region, respectively. HERDA horses exhibited decreased corneal thickness and increased corneal curvature and corneal diameters. The HRM assay resulted in high accuracy and precision. The estimated carrier frequency was 4.7%. Despite of the regional pattern of the dermatological signs, the decrease of skin thickness from HERDA horses is not regional. Skin samples of the neck, croup or back are recommended to diagnose HERDA. The relevance of the ocular findings should be further investigated. The standardized HRM assay will be useful in the management of breeding programs to minimize the occurrence of this disease
Doutor
Casas, Fernando Constantino. "A seborrheic dermatitis in pygmy goats." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385334.
Повний текст джерелаWäster, Larsson Petra. "UVA/B induced redox alterations and apoptosis in human melanocytes." Doctoral thesis, Linköpings universitet, Dermatologi och venerologi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8880.
Повний текст джерелаVenning, Vanessa Ann. "Bullous pemphigoid : clinical and pathogenetic studies." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334938.
Повний текст джерелаSouza, Tatiana Mello de. "Dermatopatias não-tumorais em cães: bases para o diagnóstico e dados de prevalência em Santa Maria, Rio Grande do Sul (2005-2008)." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/4036.
Повний текст джерелаThe current study stemmed from the interest in improving the diagnostic capabilities of a team consisting of two small animal clinicians and four veterinary pathologists from the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul (RS), Brazil; it was conducted from March 2005 to December 2008 as part of a doctoral project entitled "Non-tumorous dermatopathies in dogs" and was divided in two parts. The first part consists of an illustrated literature review on the histological aspects of the skin of dogs and cats, aimed to serve as a tool for dermatopathology, and on the methods applied to the dermatological diagnosis in small animals, with emphasis in the laboratory tests that support the diagnosis. The second part consists of the determination of the prevalence of dermatopathies in dogs in the municipality of Santa Maria, Rio Grande do Sul, Brazil. In this second part there is a pictorial collection, in the format of an atlas, of the main gross and histopathological aspects, that, in association with other criteria, allowed the diagnosis of the non-tumorous dermatopathies herein described. To accomplish that, the canine dermathological clinical cases seen at the Hospital Veterinário Universitário of UFSM and at a private practice from Santa Maria were followed up from March 2005 to June 2008. During this period 480 dogs with dermatological problems were examined; in 393 (81.9%) it was possible to establish a definitive diagnosis and in 87 (18.1%) the diagnosis was inconclusive. Four hundred and twenty four primary diagnosis and 78 secondary diagnosis were performed in the 393 dogs with conclusive diagnosis, totaling 502 diagnosis. The distribution of the diagnosis according to the categories of diagnosed dermatopathies was as follows: Allergic (190/502 [37.8%]), bacterial (103/502 [20.5%]), parasitic (97/502 [19.3%]), environmental (28/502 [5.6%]), mycotic (20/502 [4.0%]), endocrine (13/502 [2.6%]), keratinization defects (11/502 [2.2%]), psychogenic (9/502 [1.8%]), acquired alopecias (6/502 [1.2%]), autoimmune (6/502 [1.2%]), inherited (6/502 [1.2%]), pigmentary abnormalities (1/502 [0.2%], nutritional (1/502 [0.2%]), and sundry conditions (11/502 [2.2%]). In general, the ten most frequently diagnosed non-tumorous dermatopathies in decreasing order of frequency were: Atopy, flea bite allergic dermatitis, superficial bacterial folliculitis, demodectic mange, deep bacterial folliculitis/furunculosis, sarcoptic mange, myiasis, food allergy, pyotraumatic dermatitis, and Malassezia dermatitis. These 10 conditions together made up approximately for 75% of all canine skin diseases diagnosed in the current study. Such a result supports the view that a few skin diseases make up for the most part of the dermatological clinical cases seen in dogs from Santa Maria.
Este estudo derivou do interesse no aperfeiçoamento do diagnóstico dermatológico de uma equipe formada por dois clínicos de pequenos animais e por quatro patologistas veterinários vinculados ao Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul (RS), Brasil; foi conduzido no período de março de 2005 a dezembro de 2008, faz parte do projeto de doutorado intitulado Dermatopatias não-tumorais em cães e foi dividido em duas partes. A primeira parte consiste de uma revisão de literatura ilustrada sobre os aspectos histológicos da pele de cães e gatos como ferramenta para dermatopatologia e sobre métodos de diagnóstico dermatológico aplicados para pequenos animais, com ênfase em exames laboratoriais que servem de apoio diagnóstico. A segunda parte consiste na determinação da prevalência das dermatopatias nãotumorais em cães do município de Santa Maria, RS, Brasil. Nessa segunda parte há um apanhado fotográfico, no formato de um atlas, dos principais aspectos macroscópicos e microscópicos, que, juntamente com outros critérios, permitiram os diagnósticos das dermatopatias não-tumorais aqui descritas. Para isso, foram acompanhados os atendimentos dermatológicos no Hospital Veterinário Universitário da UFSM e de um consultório veterinário particular no período de março de 2005 a junho de 2008. Durante esse período foram atendidos 480 cães com problemas dermatológicos. Desses, em 393 (81,9%) foi possível estabelecer o diagnóstico definitivo e em 87 (18,1%) o diagnóstico não foi conclusivo. Esses 393 cães com diagnóstico conclusivo totalizaram 502 diagnósticos, 424 diagnósticos primários e 78 diagnósticos secundários. A distribuição dos diagnósticos em relação às categorias de dermatopatias diagnosticadas foi a seguinte: dermatopatias alérgicas (190/502 [37,8%]), dermatopatias bacterianas (103/502 [20,5%]), dermatopatias parasitárias (97/502 [19,3%]), dermatopatias relacionadas ao ambiente (28/502 [5,6%]), dermatopatias fúngicas (20/502 [4,0%]), dermatopatias endócrinas (13/502 [2,6%]), defeitos da ceratinização (11/502 [2,2%]), dermatopatias psicogênicas (9/502 [1,8%]), alopecias adquiridas (6/502 [1,2%]), dermatopatias auto-imunes (6/502 [1,2%]), dermatopatias hereditárias (6/502 [1,2%]), anormalidades pigmentares (1/502 [0,2%], dermatopatias nutricionais (1/502 [0,2%]) e outras dermatopatias (11/502 [2,2%]). No geral, as 10 principais dermatopatias não-tumorais, em ordem decrescente de freqüência, foram: atopia, dermatite alérgica à picada de pulga, foliculite bacteriana superficial, sarna demodécica, foliculite bacteriana profunda/furunculose, sarna sarcóptica, miíase, alergia alimentar, dermatite piotraumática e malassezíase. Essas 10 condições perfizeram juntas aproximadamente 75% de todas as doenças de pele de cães diagnosticadas neste estudo, o que reforça a idéia corrente de que poucas doenças de pele são responsáveis pela maior parte dos atendimentos dermatológicos no município de Santa Maria.
Winter, Randi P., Lorin Bibb, and Stuart S. Dr Leicht. "Pressure-induced Lipodystrophy from Elbow Compression." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/59.
Повний текст джерелаCastro, Eneida Lazzarini de 1955. "O conhecimento e o ensino sobre as doenças sexualmente transmissíveis entre os alunos da Unicamp." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311632.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Introdução: O ensino superior deve educar socialmente o cidadão, independente da sua área de conhecimento. As doenças sexualmente transmitidas (DST) são a principal causa global de doença aguda e morte e representam elevado custo socioeconômico. Os universitários são altamente expostos e ter outras infecções aumenta enormemente o risco de contrair o HIV. Objetivos: Avaliar o conhecimento de universitários sobre as DST, desenvolvendo um instrumento didático de autopercepção deste (des)conhecimento sobre o tema. Material e métodos: Um questionário foi enviado aos graduandos da Universidade Estadual de Campinas no final de 2011 e, em 2012, aos alunos recém-ingressos. Resultados e conclusões: Responderam o questionário 1.448 veteranos e 371 calouros. Metade era de cada sexo e houve representatividade de todas as áreas. Não tinham tido atividade sexual 20,0 e 38,0% dos veteranos e calouros, respectivamente. Dos alunos que já haviam tido, 26,9% não tinham parceria fixa e 28,2% mais que 2 parcerias/ano. A bissexualidade foi informada por 9,0% dos alunos, enquanto 5,8% dos homens e 1,1% das mulheres a homossexualidade. O preservativo foi usado por 99% dos alunos, mas menos de 20% deles fazia uso adequado do mesmo. Entre os alunos, 43% entenderam errado um slogan da campanha do governo. Cerca de 80% não sabiam que o preservativo não protege fora da área de barreira; não souberam identificar lesões de herpes simples e que não há cura para este vírus; quando apontadas lesões discretas da infecção pelo HPV, afirmaram que elas poderiam ser confundidas com "pintas"; pretendiam ler mais sobre DST e aprenderam algo sobre o assunto. Quase a metade dos alunos julgou que uma disciplina deveria ser oferecida a todos os graduandos. Vacinação pré-exposição poderia ter sido oferecida a mais de 43% dos calouros. Os dados encontrados serão úteis para definir estratégias de prevenção e o instrumento didático poderá ser utilizado em outros ambientes de ensino
Abstract: Higher education should educate students socially, regardless of their area of expertise. STDs are a global major cause of acute illness and death and represent high socioeconomic cost. Undergraduate students are highly exposed to them. Having other infection greatly increases the risk of contracting HIV. Our goals were to develop a teaching tool to generate perception of (un) knowledge about STDs and quantify that knowledge and the interest of the students in a course about this subject. A questionnaire was sent to students from State University of Campinas in late 2011 and, in 2012, to beginner students. The questionnaire was answered by 1,448 seniors and 371 freshmen. They were half of each gender and were representative of all areas. Twenty percent of seniors and 38,0% of freshmen had no sexual activity. Among the students that already had sexual activity, 26.9% had no regular partner and 28.2% had more than 2 partnerships a year. Bisexuality was reported by 9.0% of students, while 5.8% of men and 1.1% of female referred homosexuality. The condom was used by 99% of students, but less than 20% of them made proper use of it. Among the students, 43% misunderstood a slogan of the government campaign. About 80% of them did not know that condoms do not protect the outside barrier area; were not able to identify herpes simplex lesions and there is no cure for this virus; considered that discrete HPV lesions could be confused with nevus; wanted to read more about STDs; and learned something about the subject. Nearly half of the students felt that a course should be offered to all undergraduates. Pre-exposure vaccination could have been offered to more than 43% of freshmen. Our findings will be useful to help define strategies for prevention and the teaching tool might be used in other learning environments
Mestrado
Ensino em Saúde
Mestra em Clínica Médica
Schielein, Maximilian [Verfasser], and Alexander [Akademischer Betreuer] Zink. "Mental health in dermatology: addictions in psoriasis and an outlook on the psychosocial burden of chronic skin diseases / Maximilian Schielein ; Betreuer: Alexander Zink." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1232645427/34.
Повний текст джерелаCorreia, Ana Filipa Carvalho. "Nutrição, alimentação e doenças dermatológicas: associação e perspetiva histórica – uma revisão da literatura." Bachelor's thesis, [s.n.], 2020. http://hdl.handle.net/10284/9334.
Повний текст джерелаObjetivos: A ligação entre a nutrição e a dermatologia é controversa, no entanto, tem emergido ao longo dos anos podendo ser um complemento ao tratamento convencional. O objetivo do presente trabalho é rever a literatura existente, de forma a analisar o estudo da associação entre alimentação, nutrição e as doenças dermatológicas, numa perspetiva integrada e tendo em conta a evolução histórica. Metodologia: Utilizou-se a plataforma PubMed para a recolha de dados. Resultados: Abordam-se três doenças de pele com uma etiologia inconclusiva: a acne vulgar, a dermatite atópica e a psoríase vulgar. Encontraram-se vários fatores que podem exacerbar os sintomas destas doenças. A acne é uma doença inflamatória crónica que afeta maioritariamente os adolescentes. Uma dieta com alimentos de baixo índice glicémico/carga glicémica parece reduzir a gravidade da acne. A dermatite atópica é uma doença inflamatória crónica que ocorre principalmente na infância. Presume-se que a suplementação com probióticos na infância auxilia no tratamento e, no período pré e pós-natal poderá prevenir a doença. A suplementação com vitamina D parece reduzir a gravidade dos sintomas da doença. A psoríase é uma doença crónica inflamatória e imunomediada. Indivíduos obesos com psoríase beneficiam com a perda de peso, reduzindo a gravidade dos sintomas. Conclusões: A nutrição e alimentação, per se, não apresentam um impacto significativo na terapêutica das doenças dermatológicas analisadas. Contudo, verificou-se que a intervenção nutricional, incluindo alterações dos hábitos alimentares e/ou no aporte de alguns nutrientes, poderá sempre ser considerada como meio coadjuvante da terapêutica.
Aims: The link between nutrition and dermatology is controversial, however, it has emerged over the years and can be a complement to conventional treatment. The aim of this paper is to review the existing literature, in order to analyze the study of the association between food, nutrition and dermatological diseases, in an integrated perspective and taking into account historical evolution. Methodology: The PubMed platform was used for data collection. Results: Three skin diseases with an inconclusive etiology are approached: acne vulgaris, atopic dermatitis and psoriasis vulgaris. Several factors have been found that can exacerbate the symptoms of these diseases. Acne is a chronic inflammatory disease that mostly affects adolescents. A diet with low glycemic index / glycemic load foods seems to reduce the severity of acne. Atopic dermatitis is a chronic inflammatory disease that occurs mainly in childhood. It is assumed that supplementation with probiotics in childhood helps in the treatment and, in the pre and postnatal period, may prevent the disease. Vitamin D supplementation appears to reduce the severity of the disease's symptoms. Psoriasis is a chronic inflammatory and immune-mediated disease. Obese individuals with psoriasis benefit from weight loss by reducing the severity of symptoms. Conclusions: Nutrition and food, per se, have no significant impact on the treatment of the dermatological diseases analyzed. However, it was found that nutritional intervention, including changes in eating habits and / or in the supply of some nutrients, can always be considered as an adjunct to therapy.
N/A
Nie, Yali. "Automatic Melanoma Diagnosis in Dermoscopic Imaging Base on Deep Learning System." Licentiate thesis, Mittuniversitetet, Institutionen för elektronikkonstruktion, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-41751.
Повний текст джерелаAmarante, Cristina Fernandes do. "An?lise epidemiol?gica das dermatopatias de uma popula??o canina atendida no per?odo de 2005 a 2010 no Setor de Dermatologia do Hospital Veterin?rio da Universidade Federal Rural do Rio de Janeiro." Universidade Federal Rural do Rio de Janeiro, 2012. https://tede.ufrrj.br/jspui/handle/jspui/1780.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
In Brazil, epidemiological studies on canine dermatopathies are scarce and the literature point out several gaps in knowledge about. The aim of this study was to describe the profile of canine population with dermatopathies attended by the Section of Dermatology, Rural Federal University of Rio de Janeiro, testing associations with variables inherent to animals, eating habits, hygiene and in relation to concurrent dermatopathies. The records of all animals attended between January 2005 and December 2010 were organized in a database using the software Epi Info? version 3.5.1. The Chi-square ?? test or Fisher?s exact test, the prevalence ratios and their confidence intervals, the ?? test for linear trend and the respective Odds ratios were used to evaluate the associations. The level of significance adopted was 5%. We reviewed the records of 2,280 dogs, with a total of 3,433 diagnostics, and 113 types of dermatopathies were identified. The population studied was composed predominantly of females (55.2%), adults (58.3%) and defined breed animals (67.32%). The categories of dermatopathies more prevalent were: allergic (41.35%), bacterial (23.94%) and endocrines (22.41%). The categories not zoonotic (94.12%) predominated over zoonotic diseases (5.88%). The more prevalent dermatitis were: atopic dermatitis - AD (31.67%), hypothyroidism (20.75%), bacterial folliculitis (8.42%), demodicosis (8.29%), flea infestation (7.67%) otitis by M. pachydermatis (6.14%), bacterial otitis (5.92%) and flea allergic dermatitis ? FAD (5.8%). Sex was significantly associated with AD, hepatoid adenoma, acute moist dermatitis - AMD, hypothyroidism, hyperadrenocorticism and demodicosis. Significant differences were observed in relation to age and AD, folliculitis, hypothyroidism, hyperadrenocorticism, scabiosis, demodicosis, dermatophytosis, systemic lupus erythematosus and neoplasms. The prevalence of AD, FAD, contact dermatitis, hypothyroidism, scabiosis, discoid lupus erythematosus, otohematoma and neoplasms varied with significant differences in relation to animal breed. In addition, there are statistical evidences of association between: AD and hypothyroidism, use of perfumes and cleaning products; FAD and AD, food allergic dermatitis and type of food; AMD and neutering, hair type and AD; hypothyroidism and neutering; demodicosis, hair type and neutering; sporotrichosis and contact with injuried animals. The study population is characterised by high prevalence of dermatopathies of the categories allergic, bacterial, endocrines, fungal and parasitic diseases and low prevalence of dermatozoonoses. The nosology of the population studied is consistent with the type of service offered by the Section of Dermatology, which is most seek for solving complex problems and in several occasions by private practitioners. It should be noted that the studied population was examined by a dermatologist from an University Veterinary Hospital where the technology could overcome the private clinics. Therefore, despite the validity of results, these should not be extrapolated without care for other populations. The variety of the diagnostics performed indicates that the diagnosis and management of dermatopathies must receive higher attention from graduates and specialists
No Brasil, estudos epidemiol?gicos sobre dermatopatias caninas s?o escassos e a literatura aponta v?rias lacunas no conhecimento. O objetivo deste estudo foi descrever o perfil da popula??o canina atendida no Setor de Dermatologia da Universidade Federal Rural do Rio de Janeiro, e das dermatopatias, testando-as quanto ?s associa??es com vari?veis inerentes aos animais, seus h?bitos alimentares, higi?nicos e em rela??o ?s dermatopatias concorrentes. Os dados de todos os prontu?rios de animais atendidos no per?odo de janeiro de 2005 a dezembro de 2010 foram armazenados em um banco de dados elaborado no programa Epi Info? vers?o 3.5.1. O teste ?? ou exato de Fisher, as raz?es de preval?ncias e seus respectivos intervalos de confian?a, o ?? de tend?ncia linear e as respectivas odds ratio foram empregados na avalia??o da associa??o. O n?vel de signific?ncia adotado foi de 5%. Foram revisados os prontu?rios de 2.280 c?es, nos quais foram realizados 3.433 diagn?sticos e identificadas 113 dermatopatias diferentes. A popula??o estudada foi composta predominantemente por f?meas (55,2%), adultos (58,3%) e animais com ra?a definida (67,32%). As categorias de dermatopatias mais prevalecentes foram: as al?rgicas (41,35), as bacterianas (23,94%) e as end?crinas (22,41%). As categorias n?o zoon?ticas (94,12%) prevaleceram sobre as zoon?ticas (5,88%). As dermatites mais prevalecentes foram: dermatite at?pica- DA (31,67%), hipotireoidismo (20,75%), foliculite bacteriana (8,42%), demodicose (8,29%), infesta??o por pulga (7,67%) otite por M. pachydermatis (6,14%), otite bacteriana (5,92%) e dermatite al?rgica por picada de pulga- DAPP (5,8%). O sexo esteve associado significativamente a DA, ao adenoma hepat?ide, a dermatite ?mida aguda- DUA, ao hipotireoidismo, ao hiperadrenocorticismo e ? demodicose. Diferen?as significativas foram observadas em rela??o ? idade e a DA, ? foliculite, ao hipotireoidismo, ao hiperadrenocorticismo, ? escabiose, ? demodicose, ? dermatofitose, ao l?pus eritematoso sist?mico, e as neoplasias. As preval?ncias de DA, DAPP, dermatite por contato, hipotireoidismo, escabiose, l?pus eritematoso disc?ide, otohematoma e neoplasias variaram com diferen?as significativas em rela??o ? ra?a. H? evid?ncias estat?sticas de associa??o entre: DA e hipotireoidismo, uso de perfumes e produtos de limpeza; DAPP e DA, dermatite al?rgica alimentar e tipo de alimento; DUA e castra??o, tipo de pelagem e DA; hipotireoidismo e castra??o; demodicose, tipo de pelagem e castra??o; esporotricose e contactantes com les?o. A popula??o estudada caracteriza-se por apresentar altas preval?ncias de dermatopatias nas categorias al?rgicas, bacterianas, end?crinas, parasit?rias e f?ngicas e baixas preval?ncias de dermatozonoses. O quadro nosol?gico da popula??o ? coerente com o tipo de servi?o oferecido pelo setor de dermatologia, que ? mais procurado para resolver problemas complexos e em muitas ocasi?es por indica??o de cl?nicos gerais. Deve-se ressaltar que popula??o estudada foi examinada por dermatologista em Hospital Veterin?rio de uma Universidade onde a capacidade tecnol?gica pode superar a da maioria das clinicas privadas. Portanto, apesar da validade interna dos resultados obtidos, estes n?o devem ser extrapolados sem os devidos cuidados para outras popula??es. A variedade de diagn?sticos realizados indica que o diagn?stico e o manejo das dermatopatias devem receber maior aten??o por parte dos graduandos e especialistas
Clark, Michael Edward. "Unravelling the potential applications of extracellular vesicles for the clinical management of melanoma patients." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2021. https://ro.ecu.edu.au/theses/2485.
Повний текст джерелаSilva, Ana Paula da. "Suscetibilidade antimicrobiana de Staphylococcus spp. isolados de cães com pioderma superficial." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/10179.
Повний текст джерелаPioderma superficial é a infecção bacteriana da epiderme e folículo piloso e é considerada uma das doenças de pele mais frequentes em cães. Os principais agentes etiológicos envolvidos são bactérias do gênero Staphylococcus. Essa dermatopatia representa uma das principais indicações de antimicrobianoterapia pelos clínicos de pequenos animais, procedimento habitualmente realizado de forma empírica. A emergência de espécies estafilococos multirresistentes em infecções cutâneas tem sido relatada em diversos países e implica em dificuldades no tratamento. Este estudo teve como objetivo determinar a suscetibilidade antimicrobiana e avaliar a presença de multirresistência em 154 isolados de Staphylococcus spp. oriundos de lesões cutâneas de cães com pioderma superficial atendidos no Serviço de Dermatologia Veterinária do Hospital Veterinário Universitário (HVU) da Universidade Federal de Santa Maria (UFSM). Após cultura e identificação bacteriana, os isolados foram submetidos ao teste de sensibilidade aos antimicrobianos, cujos resultados evidenciaram elevados percentuais de resistência frente à amoxicilina (60,4%) e penicilina G (60,4%), moderada resistência às sulfonamidas potencializadas (29,9%), enrofloxacina (20,1%), ciprofloxacina (18,8%) e azitromicina (17,5%) e baixos percentuais de resistência à associação amoxicilina e ácido clavulânico (1,9%), cefalexina (1,9%), cefadroxil (1,9%) e vancomicina (0,6%). A multirresistência foi detectada em 23,4% e a resistência à meticilina em 5,8% das amostras. Pode-se concluir que os isolados de Staphylococcus spp. apresentam elevada suscetibilidade aos antimicrobianos comumente utilizados no tratamento dos piodermas superficiais em cães no HVU-UFSM, como a cefalexina e a amoxicilina associada ao ácido clavulânico, confirmando a eleição desses fármacos para o tratamento de cães com esta afecção. A suscetibilidade dos isolados frente às fluoroquinolonas, também recomendadas pela literatura como opção terapêutica nos piodermas, permite sugerir que esses fármacos não devem ser considerados na seleção empírica. A identificação de Staphylococcus spp. multirresistentes na população canina estudada justifica análises bacteriológicas periódicas e regionais de lesões cutâneas de cães com pioderma superficial, a fim de minimizar resistência bacteriana, possíveis falhas terapêuticas e também motiva a antimicrobianoterapia prudente.
Bivik, Cecilia. "Regulation of UV induced apoptosis in human melanocytes." Doctoral thesis, Linköping : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8749.
Повний текст джерелаSeifert, (Bock) Oliver. "Keloids - A fibroproliferative disease." Doctoral thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-10360.
Повний текст джерелаStrassner, James P. "The Role of Interferon Gamma in Melanocyte Clearance During Vitiligo." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1023.
Повний текст джерелаHjorth-Hansen, Henrik. "Novel cytokines in growth control and bone disease of multiple myeloma." Doctoral thesis, Norwegian University of Science and Technology, Faculty of Medicine, 2001. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-315.
Повний текст джерелаMyelomatose (benmargskreft) er en blodsyk dom som rammer ca 200 nordmenn årlig. Sykdommen kan ikke kureres og karakteriseres av symptomer som benmargssvikt og infeksjonstendenns, men kanskje først og fremst av sykelig nedbrytning av skjelettet. Pasientene rammes i høy utstrekning av benbrudd, hvirvelsammenfall og skjelettsmerter. Mekanismene for bennedbrytning og vekstkontroll står sentralt i avhandlingsarbeidet som består av fem artikler om cytokiners rolle i myelomatose. Cytokiner er signalsubstanser som benyttes i celle-celle-kommunikasjon. Det er sannsynligvis ubalanse av cytokiner som forårsaker den sykelige nedbrytningen av bensubstansen.
Det første delarbeidet omhandler funnet av hepatocyttvekstfaktor (HGF) som er uttrykt hos nesten alle pasienter med myelomatose Dette påvises med forskjellige teknikker og det benyttes bl a en separasjonsmetode for myelomceller basert på Ugelstadkuler som ble utviklet ved IKM i 1993. Videre påvises forhøyede nivåer av HGF i serum fra pasienter. Et interessant funn er at HGF reseptor også er uttrykt i pasientprøver, hvilket kan tale for at myelomceller kan ha en selvstimulerende (autokrin) funksjon.
I det andre delarbeidet vises en dyremodell for myelomatose i immundefekte mus. Et hovedpoeng er at det lar seg gjøre å få vekst av myelomceller i musebenmarg med påvisbare tegn til patologisk bennedbrytning på røntgen og ved histologisk undersøkelse. Musene har forhøyede nivåer av HGF i serum. Benlesjonene ble karakterisert ved hjelp av histomorfometri. Denne undersøkelse viste 99% reduksjon av de bendannende cellene (osteoblaster) og 33% reduksjon av bennedbrytende celler (osteklaster).
I tredje delarbeidet viser man at HGF induserer interleukin (IL)-11-produksjon i osteoblaster. IL-11 er en kjent påskynder av benresorpsjon og osteoklastaktivator. Et interessant fenomen er at HGF ser ut til å være bundet til heparansulfat på cellemembranen og at slikt membranbundet HGF virker bedre enn løselig HGF. Effekten av HGF potensieres av cytokinene TGF-beta og IL-1. En styrke ved arbeidet er at såvel ferskisolerte pasientceller som cellelinjer viser identiske mønstre. Arbeidet angir en mulig måte som HGF kan befremme bennedbrytning.
I fjerde delarbeid vises at cytokinet IL-15 forhindrer programmert celledød (apoptose) i myelomcellelinjen OH-2. Det var fra før kjent at myelomceller relativt hyppig lar seg stimulere av cytokinet IL-6, som fortsatt er den mest anerkjente myelomvekstfaktoren. IL-15 var tilnærmet like potent antiapoptotisk som IL-6, og befremmet også kortvarig proliferasjon. IL-15s effekt kunne potensieres av TNF-alfa
I femte delarbeid påvises at cytokinet benmorfogent protein (BMP)-4 hemmer vekst av myelomceller. BMP-4 befremmer bendannelse. Effekten av BMP-4 kom fram i IL-6-stimulerte cellelinjer og pasientprøver. Effekten skyldtes såvel induksjon av apoptose som stopp i cellesyklus G1-fase. Dette er et mulig viktig funn siden man kan tenke seg at pasienter med myelomatose kunne behandles med BMP-4 eller lignende substanser. På slik måte ville såvel skjelettnedbrytningen som myelomcellevekst kunne påvirkes gunstig.
Arbeidet bidrar til forståelse av molekylære mekanismer for bendestruksjon og myelomcellevekst og ble veiledet av profesor dr. med. Anders Waage. Henrik Hjorth-Hansen har vært stipendiat i Den norske kreftforening, og undersøkelsen ble dessuten støttet av Kreftfondet ved RiT og Blix’ legat.
Burge, Susan Mary. "Darier's disease." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306219.
Повний текст джерелаGånemo, Agneta. "Hereditary ichthyosis : Causes, Skin Manifestations, Treatments and Quality of Life." Doctoral thesis, Uppsala University, Dermatology and Venereology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1780.
Повний текст джерелаHereditary ichthyosis is a collective name for many dry and scaly skin disorders ranging in frequency from common to very rare. The main groups are autosomal recessive lamellar ichthyosis, autosomal dominant epidermolytic hyperkeratosis and ichthyosis vulgaris, and x-linked recessive ichthyosis. Anhidrosis, ectropion and keratodermia are common symptoms, especially in lamellar ichthyosis, which is often caused by mutations in the transglutaminase 1 (TGM1) gene. The aim of this work was to study patients with different types of ichthyosis regarding (i) the patho-aetiology (TGM1 and electron microscopy [EM] analysis), (ii) skin signs and symptoms (clinical score and subjective measure of disease activity), (iii) quality of life (questionnaires DLQI, SF-36 and NHP and face-to-face interviews) and (iv) a search for new ways of topical treatment. Patients from Sweden and Estonia with autosomal recessive congenital ichthyosis (n=83) had a broader clinical spectrum than anticipated, but a majority carried TGM1 mutations. Based on DNA analysis and clinical examinations the patients were classified into three groups, which could be further subdivided after EM analysis. Our studies indicate that patients with ichthyosis have reduced quality of life as reflected by DLQI and by some domains of SF-36, by NHP and the interviews. All the interviewees reported that their skin disease had affected them negatively to varying degrees during their entire lives and that the most problematic period was childhood. All patients with ichthyosis use topical therapy. In a double-blind study creams containing either 5% urea or 20% propylene glycol were found inferior to a cream formulation containing lactic acid 5% and propylene glycol 20% both regarding clinical improvement and thinning of the skin barrier. Improved topical therapy may reduce the need of more toxic, oral drugs. Future studies should elucidate whether this increases the quality of life of ichthyosis patients, especially if combined with more detailed information about the aetiology and inheritance of the diseases.
Murray, Caroline Siân. "Measuring disease in dermatology : studies of objective and subjective methods." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/23594.
Повний текст джерелаEl, Mansori Ibtessam Mustafa. "Thyrotropin receptor signalling links skin and thyroid disease." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/46110/.
Повний текст джерелаRodriguez-Macias, Wallberg Kenny A. "Artery Wall Imaging and Effects of Postmenopausal Estrogen Therapy." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5722.
Повний текст джерелаDawe, Robert Stewart. "Phototherapy in the treatment of skin disease in Scotland." Thesis, University of Glasgow, 2001. http://theses.gla.ac.uk/5857/.
Повний текст джерелаKhan, Gul Karim. "The measurement of disability caused by skin disease." Thesis, Bangor University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302336.
Повний текст джерелаPavez, Loriè Elizabeth. "Retinoic Acid Metabolism Blocking Agents and the Skin : In vivo and in vitro Studies of the Effects on Normal and Diseased Human Epidermis." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9325.
Повний текст джерелаYell, Jennifer Anne. "The 52 and 60 kD Ro/SS-A : antigens where are they? : do anti-Ro/SS-A autoantibodies cause cutaneous disease?" Doctoral thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/25683.
Повний текст джерелаArmstrong, Angela. "Dermoscopy : An Evidence-Based Approach for the Early Detection of Melanoma." UNF Digital Commons, 2011. http://digitalcommons.unf.edu/etd/382.
Повний текст джерелаAhmed, Refat Maggi. "Improving the Success of Melanocyte Keratinocyte Transplantation Surgery in Vitiligo; The Role of JAK Inhibitors, and Ablative Laser Resurfacing." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1143.
Повний текст джерелаSimpson, Rosalind C. "Erosive lichen planus affecting the vulva : defining the disease, developing outcome measures and designing a randomised controlled trial." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/28301/.
Повний текст джерелаZethelius, Björn. "Proinsulin and Insulin Sensitivity as Predictors of Type 2 Diabetes Mellitus and Coronary Heart Disease : Clinical Epidemiological Studies with up to 27 Years of Follow-Up." Doctoral thesis, Uppsala University, Geriatrics, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3159.
Повний текст джерелаDefects in insulin secretion and insulin action are the major abnormalities in the development of Type 2 diabetes. Hyperinsulinemia is a risk marker for Type 2 diabetes and according to some, but not in all studies also for coronary heart disease (CHD). Conventional insulin assays measure immunoreactive insulin including proinsulin-like molecules.
Proinsulin and insulin measured by specific methods, insulin sensitivity measured by the euglycemic insulin clamp and early insulin response after a glucose challenge give more detailed information and may be better estimates of true risk for Type 2 diabetes and CHD.
This study examined relationships between proinsulin, insulin, insulin secretion and insulin sensitivity for the development of Type 2 diabetes and CHD. The investigation of the prognostic significance of proinsulin and insulin for the development of Type 2 diabetes and CHD was performed in prospective studies of 50-year and 70-year-old men in a population-based cohort. The results indicated, that increased proinsulin concentrations, was a marker of increased risk for Type 2 diabetes independent of measurements of insulin secretion and insulin sensitivity whereas insulin was not. Proinsulin was shown to be a predictor for CHD mortality and morbidity, respectively, independent of conventional risk factors, whereas insulin was not. Insulin sensitivity measured by the gold standard euglycemic insulin clamp at age 70 was a predictor of CHD morbidity, independently of established risk factors.
In summary, these data provide evidence that an increased concentration of proinsulin and not an elevated plasma insulin level per se, that constitutes the association with Type 2 diabetes and CHD and that insulin resistance per se, is associated with CHD risk.
Defekter i insulinsekretionen och insulinkänsligheten i målorganen för insulin är de huvudsakliga orsakerna till utvecklandet av typ-2 diabetes. Förhöjd insulinhalt i blodet indikerar nedsatt känslighet för insulin och är en riskmarkör för typ-2 diabetes men också för hjärt-kärlsjukdom enligt vissa studier.
Konventionella insulinmätmetoder är ospecifika och mäter immunoreaktivt insulin som förutom insulin också innehåller ett förstadium till insulin, proinsulin.
Proinsulin och specifikt insulin, insulinkänslighet bestämd med hyperglykemisk insulin clamp teknik och tidigt insulinsvar vid sockerbelastning ger en bättre och mer detaljerad och precis information. Dessa variabler kan därför utgöra en bättre prediktor för typ-2 diabetes och hjärt-kärlsjukdom.
I denna avhandling har proinsulin, specifikt insulin, tidigt insulinsvar vid sockerbelastning och insulinkänslighet jämförts med varandra som prediktorer för utvecklandet av typ-2 diabetes och hjärt-kärlsjukdom. Två studier har omfattat risken för diabetes och två studier risken för hjärt-kärlsjukdom. Män i medelåldern respektive i högre ålder har studerats. Studierna har utförts i en populations-baserad grupp, en kohort som har sitt ursprung i en stor hälsoundersökning som genomfördes i Uppsala 1970 till 1973.
Resultaten visar att proinsulin, i motsats till specifikt insulin, är en riskmarkör för utveckling av typ 2 diabetes, oberoende av insulinkänslighet och tidigt insulinsvar vid sockerbelastning. Vidare har visats att proinsulin i motsats till specifikt insulin är en riskmarkör för död respektive sjuklighet i hjärt-kärlsjukdom, oberoende av de kända riskfaktorerna rökning, högt blodtryck och förhöjt kolesterol. Slutligen har visats att insulinkänsligheten i sig är en riskmarkör för hjärt-kärlsjuklighet oberoende av ovanstående riskfaktorer förutom proinsulin.
Sammanfattningsvis visar resultaten i avhandlingen att det snarare är proinsulinhalten och inte insulinnivån i blodet som står för de observerade sambanden med typ 2 diabetes och hjärt-kärlsjukdom. Nedsatt känslighet för insulin i sig är förenat med ökad risk för hjärt-kärlsjukdom.
Sköldberg, Filip. "Studies of Autoantibodies in Systemic and Organ-Specific Autoimmune Disease." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3421.
Повний текст джерелаSmith, Catherine Claire. "The mouse tail model in dermatology : a histological study on the effects of crude coal tar and isoquinoline." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236062.
Повний текст джерелаBerglin, Ewa. "Predictors of disease onset and progression in early rheumatoid arthritis : A clinical, laboratory and radiological study." Doctoral thesis, Umeå : Public Health and Clinical Medicine, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-669.
Повний текст джерелаLindqvist, Per. "Right heart function in health and disease : a Doppler echocardiography and Doppler tissue imaging study /." Doctoral thesis, Umeå : Department of Public Health and Clinical Medicine, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-392.
Повний текст джерелаRauma-Pinola, T. (Tanja). "Adenovirus endocytosis and adenoviral gene transfer in cardiovascular and dermatologic disease models." Doctoral thesis, University of Oulu, 2004. http://urn.fi/urn:isbn:9514274342.
Повний текст джерелаLindberg, Anne. "Chronic obstructive pulmonary disease (COPD) : prevalence, incidence, decline in lung function and risk factors." Doctoral thesis, Umeå : Public Health and Clinical Medicine, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-347.
Повний текст джерелаJohnston, Nina. "Low-Density Lipoprotein Oxidation and Renal Dysfunction : New Markers of Poor Prognosis in Patients with Unstable Coronary Artery Disease." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6626.
Повний текст джерелаHönzke, Stefan [Verfasser]. "In vitro Skin Disease Equivalents and their Applications in Basic Dermatologic Research / Stefan Hönzke." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1159900620/34.
Повний текст джерелаKristjánsson, Guðjón. "Food Antigen Sensitivity in Coeliac Disease Assessed by the Mucosal Patch Technique." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6020.
Повний текст джерелаA diagnosis of coeliac disease (CD) in adults relies on the presence of a structurally abnormal intestinal mucosa, followed by a clear clinical remission on a gluten-free diet. There is a clear need for a rapid, simple, safe and sensitive method to determine the type and intensity of inflammation in the gut mucosa in clinical practice. The overall aims of our studies were to develop and evaluate a new technique, “the mucosal patch technique”, to characterize rectal local inflammatory process after rectal food challenge in patients with CD. In study 1 we evaluated the potential of the new technique. The technique was well tolerated and easily applied. Pronounced neutrophil and eosinophil involvement in ulcerative colitis (UC) was demonstrated. With the high sensitivity of the technique, low-degree mucosal neutrophil activation could also be quantified in patients with collagen colitis,UC in clinical remission and in patients with irritable bowel syndrome. In study 2 and 3 the aim was to elucidate the dynamics of the rectal inflammatory response and nitric oxide (NO) production after rectal gluten challenge. We found a pronounced neutrophil activation in coeliac patients after rectal gluten challenge. This activation was apparent 4 hours after challenge and remains for at least 48 hours. A more modest eosinophil activation started 1-2 hours later and remained at least for 48 hours. The biphasic pattern of neutrophil and eosinonphil activation after challenge suggests a biphasic inflammatory reaction. The activation of neutrophils and eosinophils precedes a pronounced enhancement of mucosal NO production. Some of our coeliac patients displayed signs of an inflammatory reaction after rectal corn gluten challenge. In study 4 the aim was to investigate the local inflammatory reaction to gluten and cow’s milk protein in CD patients in remission. The findings indicate that not only gluten sensitivity but also cow’s milk (CM) protein sensitivity is common in CD. The data support the hypothesis that CM sensitivity may contribute to persistent symptoms in coeliac patients on gluten-free diet.
Bukachi, Frederick. "Ventricular Long Axis Function: Amplitudes and Timings : Echocardiographic Studies in Health and Disease." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-282.
Повний текст джерелаDinh, Kate H. "Sentinel Lymph Node Biopsy in Elderly Patients with Intermediate Thickness Melanoma: A Masters Thesis." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/778.
Повний текст джерелаDinh, Kate H. "Sentinel Lymph Node Biopsy in Elderly Patients with Intermediate Thickness Melanoma: A Masters Thesis." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/778.
Повний текст джерелаSchmitt, Jochen, Elisabeth Heese, Gottfried Wozel, and Michael Meurer. "Effectiveness of Inpatient Treatment on Quality of Life and Clinical Disease Severity in Atopic Dermatitis and Psoriasis Vulgaris – A Prospective Study." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135494.
Повний текст джерелаDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
Schmitt, Jochen, Elisabeth Heese, Gottfried Wozel, and Michael Meurer. "Effectiveness of Inpatient Treatment on Quality of Life and Clinical Disease Severity in Atopic Dermatitis and Psoriasis Vulgaris – A Prospective Study." Karger, 2007. https://tud.qucosa.de/id/qucosa%3A27655.
Повний текст джерелаDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Chamcheu, Jean Christopher. "Disease-causing Keratin Mutations and Cytoskeletal Dysfunction in Human Skin : In vitro Models and new Pharmacologic Strategies for Treating Epidermolytic Genodermatoses." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123071.
Повний текст джерелаClaesson, Maria. "Women's hearts : ischaemic heart disease and stress management in women." Doctoral thesis, Umeå : Department of Public Health and Clinical Medicine, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-725.
Повний текст джерелаJames, Stefan. "Coagulation, Inflammation and Myocardial Dysfunction in Unstable Coronary Artery Disease and the Influence of Glycoprotein IIb/IIIa Inhibition and Low Molecular Weight Heparin." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3372.
Повний текст джерелаSmith, Derek Richard. "Dermatological and musculoskeletal disorders of nursing home workers in Australia, Japan, South Korea and Taiwan." University of Southern Queensland, Faculty of Sciences, 2003. http://eprints.usq.edu.au/archive/00001510/.
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