Дисертації з теми "Dementia risk"
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Cornett, Patricia F. "Risk Factors for Vascular Dementia." Thesis, University of North Texas, 2005. https://digital.library.unt.edu/ark:/67531/metadc4781/.
Повний текст джерелаMawanda, Francis. "Emerging risk factors for dementia: associations between clinical infections, PTSD, psychotropic PTSD medication use, and the risk for dementia." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/2117.
Повний текст джерелаJong, F. J. de. "Endocrine factors, retinal vessels, and risk of dementia." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/13953.
Повний текст джерелаPodewils, Laura Jean. "Physical activity and dementia risk a prospective study /." Available to US Hopkins community, 2003. http://wwwlib.umi.com/dissertations/dlnow/3080747.
Повний текст джерелаBillioti, de Gage Sophie. "Benzodiazepines and risk of dementia in the elderly." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0106/document.
Повний текст джерелаThis work deals with the risk of dementia in elderly individuals who have used benzodiazepines. These drugs deserve particular attention because (i) their use appears to be too systematic and most often chronic despite good practice guidelines recommending short durations of use (ii) their deleterious effects on cognition remain underevaluated for the long-‐term. Most of the studies conducted concluded that there was an increased risk of dementia among benzodiazepine users. In fact, a protopathic bias could, at least in part, have explained these results. Indeed, the prescription of benzodiazepines could have been motivated by the prodromes often observed several years before the clinical diagnosis of a dementia. With the aim of better controlling for this bias, the BENZODEM project used the resources of the PAQUID cohort (3777 subjects ≥65 years randomly sampled from electoral lists in South-‐West France, with a 20-‐ year follow-‐up). This project combined two cohort studies and one case-‐control. These studies concluded in a risk of dementia increased by 46 to 62% in benzodiazepine users and delayed by 5 to 15 years after treatment initiation. The second part of the programme (BENZODEM2) consisted of a case-‐control study conducted in a large sample of subjects >65 years registered in the Quebec Health care database (Régie de l’Assurance Maladie du Québec, RAMQ). It was thus possible(1) to validate the previous results by using a different population (the risk was found to be increased by 30 to 80% depending on the patterns of use regarding dose, duration and type of molecule), (2) to identify the patterns of use which appeared to be at risk; excess risk was only apparent for uses of more than three months with a marked dose-‐effect relationship, and was higher for molecules with a long elimination half-‐life. Complementary explorations using the PAQUID cohort indicated that the excess risk in exposed was not explained by a differential mortality rate between the groups compared. Other studies suggested that the link found remained independently of the prescription of other psychotropics. Another analysis in the PAQUID cohort showed that, in the absence of dementia, no difference was observed between benzodiazepine users and non-‐users with regards to the evolution of scores evaluating cognitive functions. These results led to several assumptions about the putative mechanism explaining the relationship found between benzodiazepine use and dementia: (1) benzodiazepines could be early markers of symptoms such as anxiety, depression or insomnia, which are potential prodromes or risk factors for this disease, (2) these drugs could also reduce the ability to use cognitive reserve in order to cope with early lesions of the disease during the preclinical stage, (3) the association found could also result from these two mechanisms
Eriksson, Ulrika K. "Inflammation-associated risk factors for Alzheimer's disease and dementia." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-802-0/.
Повний текст джерелаLiolitsa, Danae. "Genetic risk factors in Alzheiner's disease : a hypothesis-based candidate gene approach." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252104.
Повний текст джерелаRönnemaa, Elina. "Predictors of Dementia : Insulin, Fatty Acids and Vascular Risk Factors." Doctoral thesis, Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-164528.
Повний текст джерелаULSAM
Ding, Xiuhua. "MODELING DEMENTIA RISK, COGNITIVE CHANGE, PREDICTIVE RULES IN LONGITUDINAL STUDIES." UKnowledge, 2016. http://uknowledge.uky.edu/epb_etds/9.
Повний текст джерелаDe, Ronchi Diana. "Education and dementing disorders : the role of schooling in dementia and cognitive impairment /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-349-3/.
Повний текст джерелаO'Donovan, Simon Terence. "Dementia caregiving : burden and breakdown." Thesis, University of South Wales, 2004. https://pure.southwales.ac.uk/en/studentthesis/dementia-caregiving(34088905-f406-4d82-bc09-aeed052f5e3c).html.
Повний текст джерелаGuedes, Sandra Daniela Silva. "Testing a dementia risk group for polymorphisms in inflammation-related genes." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/18512.
Повний текст джерелаA doença de Alzheimer (AD) é uma perturbação degenerativa multifatorial associada com a idade que ocorre no sistema nervoso central. Após a sua descrição inicial em 1907, numerosas teorias foram propostas para elucidar quais as principais causas associadas. A hipótese da inflamação tem sido recentemente reconhecida pela comunidade científica, uma vez que muitos estudos em modelos e doentes de Alzheimer propuseram fortes evidências da ativação do sistema imunológico e de processos inflamatórios durante o curso da doença. De facto, a acumulação de β-amilóide (Aβ) e proteína tau provocam uma resposta inflamatória cerebral como resultado do desenvolvimento patológico da AD. Atualmente, os estudos de associação genómica genética (GWAS) proporcionaram a identificação de diversas variantes genéticas que influenciam por exemplo processos inflamatórios e as vias do sistema imunitário na AD, estando as regiões polimórficas CLU rs11136000 e CR1 rs3818361 entre elas. Além disso, ambos os polimorfismos de um único nucleótido (SNPs) parecem ter um papel colaborativo relativamente à eliminação de Aβ e à ativação do sistema imunitário através da estimulação do complemento. No trabalho aqui descrito, foram realizadas análises bioinformáticas de genes de risco para a AD, principalmente o CLU e o CR1. As informações obtidas foram usadas para criar uma rede de interação proteína-proteína, bem como para realizar análises de enriquecimento de Ontologia Genética. A nossa análise bioinformática indica que ambos os genes CLU e CR1 estão envolvidos numa variedade de vias de sinalização que compreendem a regulação do processo inflamatório e ativação do sistema imunológico. A expressão genética de cada alelo de risco das SNPs CLU rs11136000 e CR1 rs3818361 foi ainda avaliada em amostras de doentes “Putativos AD” e Controlos por testes de PCR e análises de sequenciação de Sanger. Adicionalmente, as frequências genotípicas e alélicas também foram determinadas com o intuito de criar um perfil genético dos grupos estudados. Os nossos resultados demostraram que no grupo de doentes “Putativos AD” analisado para a variante CLU rs11136000, o alelo de risco C apresentou maior frequência (64%) quando comparado com o grupo Controlos (40%). O grupo de Controlos apresentou uma frequência de 60% para o alelo de não-risco. Para a variante CR1 rs3818361, o alelo de risco A apresentou frequências semelhantes entre grupos, apesar do aumento da percentagem de homozigóticos de risco (6%) no grupo de doentes “Putativos AD”. Este trabalho auxilia na compreensão da relação entre estes polimorfismos genéticos e demência. Estudos adicionais devem avaliar o uso destas SNPs como ferramentas potencialmente úteis no diagnóstico da AD.
Alzheimer’s disease (AD) is a multifactorial age associated degenerative disorder that occurs in the central nervous system. After its initial report in 1907, numerous theories have been proposed to elucidate on what are the related main causes. The inflammation hypothesis has been recently acknowledged by the scientific community since several studies in AD models and patients strongly supported the activation of the immune system and of inflammatory processes during disease development. In fact, the accumulation of amyloid-β (Aβ) and tau-neurofibrillary tangles provokes a brain inflammatory response as a consequence of the pathological development of AD. Currently, genome-wide association studies (GWAS) have provided several genetic variants that impact inflammation and immune system pathways in AD, being the polymorphic regions CLU rs11136000 and CR1 rs3818361 among them. Furthermore, both single-nucleotide polymorphisms (SNPs) appear to have a collaborative role regarding Aβ clearance and immune system activation via complement stimulation. In the work here described, bioinformatics analyses of AD risk-related genes, focusing on CLU and CR1 were performed and the retrieved information used to rise a protein-protein interaction network, as well as to perform Gene Ontology enrichment analyses. Our bioinformatics analysis indicates that CLU and CR1 are involved in a variety of signaling pathways that comprise activation and regulation of immune system process. CLU rs11136000 and CR1 rs3818361 genetic expression of each SNP risk allele was further evaluated in whole blood samples from “Putative AD” and Controls groups by PCR assays and Sanger sequencing analyses. Additionally, the genotyping and allelic frequencies were also determined in order to create a genetic profile of the studied groups. Our results showed that on the “Putative AD” group analyzed for CLU rs11136000 variant, the C-risk allele presented a higher frequency (64%) when compared to Controls (40%). The Controls group displayed a 60% frequency for the non-risk allele. For the CR1 rs3818361 variant, the A-risk allele showed similar frequencies among groups, although an increase in the percentage of homozygous risk carriers (6%) was observed in the “Putative AD” group. This work aids into the understanding of the relation between these genetic polymorphisms and dementia. Additional studies should address the use of these SNPs as potential tools in AD diagnostics.
Duan, Ran. "EVALUATING THE IMPACTS OF ANTIDEPRESSANT USE ON THE RISK OF DEMENTIA." UKnowledge, 2019. https://uknowledge.uky.edu/epb_etds/23.
Повний текст джерелаAlford, Susan Elizabeth. "A Predictive Model for Dementia Risk in Elderly Adults with Prediabetes." ScholarWorks, 2014. https://scholarworks.waldenu.edu/dissertations/129.
Повний текст джерелаRuss, Thomas Charles. "Integrated investigation of dementia risk factors : insights from geography, record linkage, and individual participant meta-analysis." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8823.
Повний текст джерелаGarcia, Esparcia Paula. "Identification of a risk transcriptome and proteome in Parkinson’s disease, Dementia with Lewy bodies and rapidly progressive Dementia with Lewy bodies." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/664642.
Повний текст джерелаLa enfermedad de Parkinson (EP) es una patología neurodegenerativa perteneciente al grupo de afecciones conocidas como trastornos del movimiento, o parkinsonismo, para la cual actualmente no existe cura. Los signos clínicos que manifiesta son resultado de una pérdida neuronal superior al 60% en el área cerebral más afectada, la sustancia nigra pars compacta. Asimismo, la aparición de demencia y los desórdenes cognitivos en la EP conducen a una EP con demencia. A su vez, la Demencia con cuerpos de Lewy (DCL) es también una enfermedad neurodegenerativa considerada como una de las causas más comunes de demencia, con una sintomatología de deterioro cognitivo similar a la observable en la demencia de tipo Alzheimer y con la aparición de síntomas de parkinsonismo. Su aparición es insidiosa y se caracteriza por presentar una progresión lenta, a diferencia de su forma rápida también conocida como Demencia con cuerpos de Lewy rápidamente progresiva (DCLrp), que aparece de forma súbita y evoluciona vertiginosamente. En todas estas enfermedades se produce una degeneración neural debida no únicamente a la acumulación de proteínas alteradas, sino más probablemente consecuencia de múltiples factores deletéreos convergentes. La hipótesis de este trabajo es considerar que la identificación de cambios moleculares analizados gracias a la aplicación de métodos “-ómicos” servirá para obtener información sobre un trascriptoma/proteoma de riesgo en las anteriormente citadas enfermedades. El principal objetivo abordado en la presente tesis es la identificación de las alteraciones moleculares subyacentes a los cambios cerebrales funcionales y anatómicos presentes en diferentes regiones cerebrales y en distintos estadiajes de Braak de la EP, así como en la DCL y en la DCLrp, por medio del uso de muestras de cerebro humano post-mortem comparando con controles, combinando estudios de microarrays, mRNA, proteínas y ensayos enzimáticos. Los resultados obtenidos por medio de métodos de transcriptómica con su posterior validación y ampliación a proteómica han permitido identificar alteraciones moleculares en la EP, DCL y DCLrp de distintas vías metabólicas incluyendo cambios en la maquinaria de síntesis de proteínas, en el metabolismo mitocondrial y energético, en la neuroinflamación, en la vía de las purinas y en nuevas vías de señalización comprendiendo las vías de receptores olfatorios y gustativos.
Porcellini, Elisa <1978>. "Genetic and environmental factors associated with the risk of cognitive decline and dementia." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3336/.
Повний текст джерелаYesufu, Amina. "Demographic and modifiable risk factors for age related cognitive impairment and possible dementia." Thesis, Loughborough University, 2009. https://dspace.lboro.ac.uk/2134/32641.
Повний текст джерелаHatch, Daniel Joseph. "The Influence of Widowhood and Sociodemographic Moderators on Dementia and Alzheimer's Disease Risk." DigitalCommons@USU, 2013. https://digitalcommons.usu.edu/etd/1473.
Повний текст джерелаGreene, Daylee Rose. "Relationship Between Occupational Complexity and Dementia Risk in Late Life: A Population Study." DigitalCommons@USU, 2013. https://digitalcommons.usu.edu/etd/1975.
Повний текст джерелаEriksson, Staffan. "Falls in people with dementia." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1449.
Повний текст джерелаNgandu, Tiia. "Lifestyle-related risk factors in dementia and mild cognitive impairment : a population-based study /." Stockholm : Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2006. http://diss.kib.ki.se/2006/91-7140-744-8/.
Повний текст джерелаDynan, Kevin B. "A study of recently proposed cardiovascular risk factors in Alzheimer's disease and vascular dementia." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322645.
Повний текст джерелаMcCullagh, C. D. "An investigation of inflammatory and vascular genetic risk factors for stroke and dementia following stroke." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403191.
Повний текст джерелаShaw, Fiona Elisabeth. "Risk modification of falls in older patients with cognitive impairment and dementia attending a casualty department." Thesis, University of Newcastle upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391965.
Повний текст джерелаSeverin, Kimberley. "Statins and Risk of Alzheimer Disease: A Systematic Review and Meta-Analysis." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1352489450.
Повний текст джерелаMcParland, Patricia. "Dementia : what comes to mind? : an exploration into how the general public understands and responds to dementia." Thesis, University of Stirling, 2014. http://hdl.handle.net/1893/20411.
Повний текст джерелаQian, Jing, Frank J. Wolters, Alexa Beiser, Mary Haan, M. Arfan Ikram, Jason Karlawish, Jessica B. Langbaum, et al. "APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts." PUBLIC LIBRARY SCIENCE, 2017. http://hdl.handle.net/10150/623943.
Повний текст джерелаAl-Janabi, Omar M. "CEREBROVASCULAR RISK FACTORS, ARTERIOLAR SCLEROSIS, AND COGNITIVE DECLINE IN THE KENTUCKY APPALACHIAN “STROKE-BELT”." UKnowledge, 2016. http://uknowledge.uky.edu/medsci_etds/5.
Повний текст джерелаChristensen, Janelle J. "Hurricane Preparedness of Community-Dwelling Dementia Caregivers in South Florida." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4010.
Повний текст джерелаSilva, Magnolia Moreira da. "Associação entre fatores de risco cardiovasculares e demência vascular definitiva." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/7/7139/tde-05112018-151715/.
Повний текст джерелаIntroduction: Previous studies have analyzed the association between cardiovascular risk factors (CVRF) associated with the diagnosis (probable or possible) of vascular dementia (VaD). However, there are no studies that have analyzed the association between CVRF and the occurrence of definitive VaD. The association between CVRF and the occurrence of definite VaD, neuropathologically defined and considered as gold-standard, remains obscure. Objectives: To evaluate the association between CVRF and the occurrence of definitive VaD, pure and mixed. Methods: This is a cross-sectional study which evaluated 707 cases belonging to the Bain Bank of the Brazilian Aging Brain Study Group (BBBABSG) of FMUSP, respecting the inclusion criteria. The history of existence of cardiovascular risk factors in life (hypertension, diabetes mellitus, dyslipidemia, smoking, alcoholism, obesity, and sedentarism) reported by a knowledgeable next-of-kin, with at least weekly contact with the deceased, was associated with the neuropathological diagnosis of vascular dementia reported by a neuropathologist after the autopsy exam. Logistic regression models (with and without adjustment for sex, age and race) were tested to show the association between CVRF and the diagnosis of VaD, pure Vad and mixed VaD. It was also tested the predictive capacity of the factors that proved to be predictors of VaD through the ROC Curve. Results: Sedentary lifestyle was an independent predictor of VaD (OR 1,943, CI 95% 1,198 - 3,151, p = 0.007) and of Pure VaD (OR 3,148, 95% CI, 1.428 - 6.941, p = 0.004). Hypertension was an independent predictor of Mixed VaD (OR 2,240, 95% CI 1,216 - 4,126, p = 0.01). Sedentary lifestyle did not present good predictive capacity for VaD and Pure VaD (AUC = 0.380 and 0.337, respectively), as Hypertension for Mixed DV did not either (AUC = 0.459). Conclusions: Among the CVRF, sedentarism and hypertension were those associated with an increase VaD risk.
Israelsson, Larsen Hanna. "Comorbidity and vascular risk factors associated with idiopathic normal pressure hydrocephalus : the INPH-CRasH Study." Doctoral thesis, Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120175.
Повний текст джерелаIdiopatisk normaltryckshydrocefalus (INPH, från engelskans ”idiopathic normal pressure hydrocephalus”) är en neurokirurgiskt behandlingsbar demens. Behandlingen är att operera in en shunt som dränerar cerebrospinalvätska från ventriklarna. Det har föreslagits att INPH skulle kunna orsakas av liknande patofysiologiska mekanismer som vid cerebrovaskulär sjukdom, men den vaskulära riskfaktorprofilen hos INPH-patienter har aldrig undersökts i en modern epidemiologisk studie. De kognitiva symtomen vid INPH påminner om symtomen vid depression, men prevalensen av depression hos INPH-patienter är okänd. Få studier undersöker hur shuntning påverkar livskvalitet och ingen studie har undersökt hur komorbiditet påverkar livskvaliteten vid INPH. Syftet med den här avhandlingen var att undersöka den vaskulära riskfaktorprofilen hos INPH-patienter samt att utforska hypotesen att INPH skulle kunna vara en undergrupp till vaskulär demens. Ytterligare ett syfte med avhandlingen var att undersöka hur många INPH-patienter som har depression samt undersöka hur shunting och komorbiditet påverkar livskvalitet vid INPH. I den första kohorten undersöktes kliniska och radiologiska fynd som tydde på INPH hos de patienter som blivit diagnostiserade med en TIA (från engelskans: transient ischemic attack) 2006-2008 på Norrlands Universitetssjukhus i Umeå. I den andra kohorten undersöktes konsekutivt shuntade INPH-patienter 2008-2010 från fem av sex neurokirurgiska kliniker i Sverige. De patienter som inkluderades i studien (n=176, ålder: 60-85 år, ej dementa) jämfördes med köns- och åldersmatchade kontroller från normalpopulationen (n=368, samma inklusionskriterier som för INPH-patienterna). De riskfaktorer som undersöktes var: hypertension, hyperlipidemi, diabetes, fetma, psykosociala faktorer (stress och depression), rökning, alkohol, fysisk aktivitet och diet. Även kardiovaskulära och cerebrovaskulära sjukdomar undersöktes, liksom perifer vaskulär sjukdom samt livskvalitet. Datainsamling skedde genom frågeformulär, kliniska undersökningar, mätningar, EKG och blodprov. I den första kohorten hade 4% av TIA-patienterna kliniskt och radiologiskt verifierad INPH. I den andra kohorten var vaskulära riskfaktorer överrepresenterade hos INPH-patienterna jämfört med iv normalpopulationen. Hyperlipidemi (OR: 2.4, 95%CI: 1.4-4.0), diabetes (OR: 2.2, 95%CI: 1.2-3.9), fetma (OR: 5.4, 95%CI: 2.5-11.8) och psykosociala faktorer (OR: 5.3, 95%CI: 3.2-8.9) var associerade med INPH oberoende av kön, ålder och de andra riskfaktorerna. Hypertension och fysisk inaktivitet var också associerade med INPH, dock inte oberoende av övriga riskfaktorer. Sammanlagd PAR% (från engelskans: population attributable risk %) för de här sex riskfaktorerna var 24%. INPH-patienterna hade depression i högre utsträckning än kontrollerna (46% vs. 13%, p<0.001), och depression var den viktigaste prediktorn för låg livskvalitet. Resultaten tyder på att vaskulär sjukdom och vaskulära riskfaktorer är involverade i den patofysiologiska mekanismen vid INPH. INPH kan vara en undergrupp till vaskulär demens. En fullständig riskfaktoranalys och screening för depression bör ingå i den preoperativa utvärderingen såväl som i forskning på INPH-patienter, och ett mått på livskvalitet bör införas. Effekten av riktade insatser mot såväl vaskulära riskfaktorer som depression vid INPH bör utvärderas.
Gopu, Anusharani. "Using non-medical risk factors related to dementia and cognitive decline for developing an evidencebased e-health tool." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-199191.
Повний текст джерелаAntal demensfall ökar över hela världen. Forskning och utveckling inom detta område är relaterat till att förebygga demens och att utveckla olika prognosverktyg för demens. Flera tillgängliga verktyg tar hänsyn till medicinska data i beräkning av riskpoäng, med endast en liten mängd av icke-medicinska data. Det finns en hel del data om medicinska och icke-medicinska faktorer online, men de används idag inte för riskpoängberäkning. Som en del av projektet Multimodala strategier för att främja en frisk hjärna i åldrande: Innovativa evidensbaserade verktyg (MULTI-MODE), så har en ny metod utvecklats för att användas i ett nytt IT-baserat verktyg för demensförutsägelse. Identifiering av icke-medicinska data och en bra modell för att överbrygga gapet mellan tillgängliga data på servern och använda dessa data i riskberäkning kan bidra till att öka precisionen hos verktyg. I den här studien beskrivs en del befintliga riskfaktorer för förutsägelse av demens och vikten av icke-medicinska faktorer i beräkning av risk diskuteras. Ytterligare icke-medicinska faktorer identifieras som skulle kunna ingå i framtida versioner av riskverktyg (såsom appar). Vissa identifierade riskfaktorer har analyserats och visade att effekten av att införa icke-medicinska faktorer ökar precisionen i resultaten. En databasdesign för lagring av riskinformation på ett effektivt sätt presenteras, liksom en appstruktur som kan användas på serversidan för att validera några av de parametrar som kan öka effektiviteten av verktyget.
Xu, Xin. "Physical, psychological, demographic and modifiable risk factors for age related cognitive impairment associated with possible dementia and frailty." Thesis, Loughborough University, 2014. https://dspace.lboro.ac.uk/2134/14542.
Повний текст джерелаMathillas, Johan. "Dementia, depression and delirium in the very old : prevalences and associated factors." Doctoral thesis, Umeå universitet, Geriatrik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79984.
Повний текст джерелаUmeå85+/GERDA
Lundström, Maria. "Delirium in old patients with femoral neck fracture : risk factors, outcome, prevention and treatment /." Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-379.
Повний текст джерелаLundström, Maria. "Delirium in old patients with femoral neck fracture : risk factors, outcome, prevention and treatment." Doctoral thesis, Umeå universitet, Geriatrik, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-379.
Повний текст джерелаMohammad, Hameed. "Mid-to-late life overweight and obesity and the risk development of dementia: A systematic review of the literature." Thesis, Mohammad, Hameed (2020) Mid-to-late life overweight and obesity and the risk development of dementia: A systematic review of the literature. Masters by Coursework thesis, Murdoch University, 2020. https://researchrepository.murdoch.edu.au/id/eprint/59020/.
Повний текст джерелаPeters, Ruth. "Risk factors for incident cognitive decline and dementia in a very elderly hypertensive population : a two year prospective cohort study." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/11863.
Повний текст джерелаEriksson, Sörman Daniel. "The influence of social relationships and leisure activity on adult cognitive functioning and risk of dementia : Longitudinal population-based studies." Doctoral thesis, Umeå universitet, Institutionen för psykologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101840.
Повний текст джерелаHuang, Lan-Ya, and 黃蘭雅. "Risk factors for Dementia in Down syndrome." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/54225985401574473028.
Повний текст джерела國立臺灣大學
分子醫學研究所
104
Background Down syndrome (DS) is one of the most common mental retardation chromosomal disorder in Taiwan. Even though our healthcare system encourages Down syndrome screen,there is still a number of babies with DS delivered. DS babies will have be problems congenital anomalies and need to be paid more attention in education. When turning into adulthoods, early degeneration is a major concern, such as dementia. The cause of dementia in DS is not well delineated. In this study, we would like to evaluate the role of single nucleotide polymorphism (SNPs) in DS with dementia. Method We compared the percentage of several SNPs in DS with and without dementia, including 12 SNPs in APOE、ESR2、CYP17 and CYP19 genes (rs405509, rs429358, rs7412, rs17766755,rs4365213, rs12435857, rs4986938, rs6163,rs3740397,rs10786712,rs743572, and rs1870049). ABDQ (Adaptive Behaviour Dementia Questionnaire) scores, age, sex, IQ, and behavior problems were also analyzed. Result Total 23 DS subjects and 49 healthy subjects were analyzed. The dementia in DS is positively correlated with behavioral problems, IQ, ABDQ scores (p<0.001). In addition, APOE
Lu, Yun-Ru, and 盧韻如. "Risk factors in survival of vascular dementia." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/47901275615867116631.
Повний текст джерела臺灣大學
流行病學研究所
98
Background There were many survival suturies of Alzheimer''s Disease or oveall dementia. But,the study about survival of vascular dementia was few.It is fact that the etiologies of dementia are variable.The effect of vascular risk factors on dementia mortality were underestimated due to the error anaylsis of oveall dementia patients rather than vascular dementia patients.Our study was a longitudinal study of patients of vascular dementia.We recorded the whole history from stroke to vascular dementia and final mortality course in hospital.Based on the records , we want to know what risks factors were related to mortality of vascular dementia. Objective To investigate what risks factors were contributioned to mortality of vascular dementia.The risk factors include as follows: age、gender、diabetes mellitus、hypertension、angima、atrial fibrillation、poststrpke bed-ridden state、poststroke epilepsy、congestive heart failure、sepsis、the time between stroke and dementia、poststroke brain image findings.According to the survival study of vascular dementia, we could know what risk factors were highly related to mortality and we can early prevent it with drugs or health education. Method We used medical record review system to identify cases of vascular dementia from January 1, 2004 to December 31, 2009. 54 patients were identified by the criteria of National Institute of Neurological Disorders and Stroke -Association International pour la Recherché et l''Enseignement en Neurosciences (NINDS –AIREN criteria) Patients with VaD were followed from the day of VaD diagnosis to death, or the end of study. All the patients were arranged a series of tests as follows, neurological examination revealed focal neurological symptoms and signs, and serological test for dementia survey, such as T4, TSH, and VDRL. Besides, Brain CT or MRI was done to check the poststroke states and brain atrophy. Cox proportional hazards models were used to evaluate the effects of risk factors on VaD. In addition, the estimated median survival time and five-year survival rate were obtained from the Kaplan-Meier method. Result The mean age of VaD was 81.53±7.36 years.Five year survival rate was 34%. At the ending of study, there were 12 deaths among patients. There were 8 patients died from aspiration pneumonia, 1 patients died from recurrent stroke, and 1 patient died from lung cancer,1 patient died from traumatic SAH due to fall down. The RR of death was 32.27(95%CI, 6.04-172.4) in VaD patients with congestive heart failure. The RR of death was 44.79(95%CI,12.10-165.8) in VaD patients with septic shock.The Kaplan-Meier survival curves showed the trend in poor survival amongVaD patients with multiple vascular factors.Besides,VaD patients with brain image showed periventricular white matter change has better survival tham patients with brin image showed a single strategically infarct. Conclusion Five-year survival rate was 34%. Aspiration Pneumonia was the major mortality cause in our patients. Septic shock and CHF were time-dependent variables in survival of VaD. The major cause of Sepsis was aspiration pneumonia.The RR of death was 33.20 in VaD patients with septic shock adjusted by CHF.There was trend with lower survival rate among VaD patients of multiple vascular risk factors.
Lee, Jiann-Der, and 李建德. "The Risk Factors of Dementia in Hemodialysis Patients." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/44246199248014419546.
Повний текст джерела國立中興大學
生命科學院碩士在職專班
93
Dementia is one of the major causes of disability in hemodialysis patients. The purpose of this study was to evaluate the prevalence and type of dementia in hemodialysis patients, and to correlate factors which might contribute to dementia in these patients. The dementia-associated factors including age, literacy, cholesterol, triglycerides, albumin, homocysteine, diabetes mellitus, hypertension, and stroke, ischemic heart disease, and smoking were also to be determined. The predictive factor(s) for the serum concentration of homocysteine was also determined. In general, 147 hemodialysis patients from Kuang-Tien General Hospital were targeted to be analyzed. Cognitive function was evaluated by mini-mental status examination (MMSE), and dementia was further diagnosed based on the criteria of Diagnostic and Statistical Manual for Mental Disorders (DSM-IV). Hachinski ischemic scale was used to distinguish the types of dementia. Fluorescent polarizing immunoassay, chemiluminescence immunoassay, and latex agglutination test were used to determine the blood levels of homocysteine, folate & vitamin B12, and C-reactive protein, respectively. Results showed that among the 147 patients, 26 patients were diagnosed with dementia. The degenerative type dementia was more prevalent in these patients. Hemodialysis patients with hypoalbuminemia, old age, and illiteracy were prone to dementia. Although homocysteine was not statistically correlated with dementia of hemodialysis patients, we can not preclude the possibility yet because the levels of homocysteine in most of the hemodialysis patients remained above average. Multiple linear regression analysis indicates vitamin B12, creatinine, and C-reactive protein are the reliable predictors for homocysteine. Similar analyse further indicates age and triglycerides are the two reliable predictors for the change of plasma albumin.
Chen, Chia-Wen, and 陳嘉雯. "Exposure of General Anesthesia on Risk of Dementia." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/06884107259767732084.
Повний текст джерелаSequeira, Rodrigo Rodrigues Lucas Rei. "Dementia: risk factors for disease progression and mortality." Master's thesis, 2021. https://hdl.handle.net/10216/134579.
Повний текст джерелаSequeira, Rodrigo Rodrigues Lucas Rei. "Dementia: risk factors for disease progression and mortality." Dissertação, 2021. https://hdl.handle.net/10216/134579.
Повний текст джерелаHack, Erica. "Multilingualism and the risk of Alzheimer disease and dementia." Thesis, 2011. http://hdl.handle.net/10012/5999.
Повний текст джерелаKuang-MingLiao and 廖光明. "Chronic Obstructive Pulmonary Disease Increased the Risk of Dementia." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/8gde89.
Повний текст джерелаYang, Shen-Yin, and 楊聖盈. "The association between Leisure Activities and the Risk of Dementia." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/13154618398174045384.
Повний текст джерела國立臺灣大學
公共衛生碩士學位學程
99
Background: Previous studies found that leisure activities may decrease the risk of dementia, but results were inconsistent. Therefore, this study explored the association between different leisure activities and the risk of dementia. Methods: This is a case-control study. A total of 470 dementia patients [310 Alzheimer''s disease (AD) and 160 vascular dementia (VaD)] aged 50 or order was recruited from three teaching hospitals in northern Taiwan between 2007 and 2010. Health controls (n=499) were recruited from health checkup and volunteers of one hospital during the same time. Results: High frequency of physical activity was associated with a reduced risk of AD [odds ratio (OR) = 0.46, 95% confidence interval (CI) = 0.32-0.70)], results remained significant after stratified by gender (men: OR= 0.37; women: OR= 0.57). Similar finding was observed for high frequency of recreational, cognitive, productive activity (OR= 0.37, 95% CI= 0.18-0.77), and result remained significant among women (OR= 0.22), but not among men. Same for high social engagement activity (OR= 0.55, 95% CI= 0.38-0.79), but result remained significant only among men (OR= 0.48). For VaD, high frequency of physical activity and recreational, cognitive, productive activities were associated with a reduced risk of VaD (OR= 0.31, 95% CI = 0.18-0.54; OR= 0.24, 95% CI = 0.10-0.60, respectively). Physical activity was associated with a reduced risk of VaD after stratified by gender (men: OR= 0.25; women: OR= 0.41). Recreational, cognitive, productive activity was associated with a lower VaD risk in men (OR= 0.26, 95% CI= 0.08-0.85). Conclusion: High frequency of physical activity; recreational, cognitive, productive activity; and social engagement activity played a protective role on the risk of AD. Only the former two activities were associated with VaD. In addition, the associations were varied by gender. No interactions were observed for any two types of activities on the risk of AD and VaD.
Lin, Chie-Yu, and 林婕妤. "Risk factors of survival rate on patients with organic dementia." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/66354360785457801985.
Повний текст джерела東吳大學
財務工程與精算數學系
99
In this research, data from “Psychiatric Inpatient Medical Claim Dataset” is used to study four risk factors of survival rate, including gender, onset age of organic dementia, history of diabetes and history of hypertension, on patients with organic dementia. Organic dementia patients are identified by using ICD-9-CM for the “290 senile and presenile organic psychotic conditions” or “294 other organic psychotic conditions (chronic).” A sample of 43,101 patients with organic dementia are observed from 1998-2009. For patients with organic dementia, the survival rate and hazard rate function are estimated by using Kaplan-Meier Product-Limit and Cox Proportional Hazard Model. The 43,101 patients with organic dementia are divided into 3 categories by their onset age, namely onset age “between 0-49 years,” “between 50-64 years” and “over age of 65.” Patients with different onset age category apply different hazard model. For patients with onset age between 0-49 years, "gender" and "history of hypertension" are major risk factors affecting survival rate; for those without history of diabetes, the "onset age of organic dementia" is also a risk factor for survival rate. For patients with onset age between 50-65 years, “gender,” “onset age of organic dementia” and “history of diabetes” are risk factors in survival rate. For patients with onset age over age 65, “onset age of organic dementia” and “history of diabetes” are risk factors affecting the survival rate of women; but of men, "history of hypertension" is also a risk factor. The estimation of patients’ survival rate after onset of dementia is lower than that besed on “2002 TSO Experience Mortality Table” and “Annuity Table in 1997”. That is, 2002 TSO Experience Mortality Table and Annuity Table in 1997 may not suit for estimating patients’ survival. In conclusion, when underwriting long-term care insurance, “history of diabetes” and “history of hypertension” of the insured had better be declared. For the in-force business, the hazard model could be a good reference for insurer to access future risk.